150 results match your criteria Lobomycosis


Posaconazole for lobomycosis.

Braz J Infect Dis 2021 Mar-Apr;25(2):101576. Epub 2021 Apr 12.

Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, RS Brazil.

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A global view on fungal infections in humans and animals: infections caused by dimorphic fungi and dermatophytoses.

J Appl Microbiol 2021 Mar 23. Epub 2021 Mar 23.

Faculty of Biological Sciences, Department of Mycology and Genetics, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland.

Fungal infections are still underappreciated and their prevalence is underestimated, which renders them a serious public health problem. Realistic discussions about their distribution, symptoms, and control can improve management and diagnosis and contribute to refinement of preventive actions using currently available tools. This article represents an overview of dermatophytes and endemic fungi that cause infections in humans and animals. Read More

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Multidrug Therapy for Leprosy Can Cure Patients with Lobomycosis in Acre State, Brazil: A Proof of Therapy Study.

Am J Trop Med Hyg 2020 Nov 16. Epub 2020 Nov 16.

Setor de Pós-graduação, Pesquisa e Inovação, Centro Universitário Saúde ABC, Fundação ABC, Santo André, Brazil.

Lobomycosis, also referred to as lacaziosis, is an endemic cutaneous and subcutaneous fungal disease that mainly affects Amazonian forest dwellers in Brazil. There is no disease control program in place in Brazil, and antifungal therapy failures are common, and the therapy is inaccessible to most patients. We performed a randomized, unblinded clinical trial testing the cure rate of multiple drug therapy (MDT) for leprosy with surgical excision, with or without itraconazole. Read More

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November 2020

Comparative effect of osmium tetroxide and ruthenium tetroxide on Lacazia loboi ultrastructure.

Microsc Res Tech 2021 Apr 11;84(4):789-795. Epub 2020 Nov 11.

Grupo de Morfología Celular, Dirección de Investigación en Salud Pública, Instituto Nacional de Salud, Bogotá, Colombia.

Lobomycosis is a skin infection produced by the fungus Lacazia loboi, which mainly affects some indigenous and afro-descendant populations in Tropical America. We previously reported the comparative effect of osmium tetroxide (OsO ) and ruthenium tetroxide (RuO ) in the electron microscopy (EM) of other related microorganisms. The objective of this study is to compare the effect of postfixation with OsO and RuO in the ultrastructure of L. Read More

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Lacaziosis: immunohistochemical evaluation of elements of the humoral response in cutaneous lesions.

Rev Inst Med Trop Sao Paulo 2020 9;62:e75. Epub 2020 Oct 9.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.

Lacaziosis is a cutaneous mycosis caused by the fungus Lacazia loboi, described in different countries of Latin America and prevalent in the Amazon region. The ineffective immune response against the agent seems to be related to a Th2 pattern of cytokines. There are few reports exploring elements of the humoral response in these lesions. Read More

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October 2020

Lacaziosis (Lobomycosis) From Southern Mexico: A Case Confirmed by Molecular Biology.

Mycopathologia 2020 08 7;185(4):737-739. Epub 2020 Jun 7.

Dermatology Department and Laboratory of Mycology, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.

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M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis.

Mycopathologia 2020 Jun 6;185(3):477-483. Epub 2020 May 6.

Laboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil.

Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. Read More

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What is your diagnosis? Keloidal cord-like lesion on the leg.

An Bras Dermatol 2020 May - Jun;95(3):386-389. Epub 2020 Mar 19.

Department of Dermatopathology, Fundação Alfredo da Matta de Dermatologia e Venereologia, Manaus, AM, Brazil.

We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. Read More

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Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965-2019.

Emerg Infect Dis 2020 05;26(5):930-936

Lobomycosis is a rare granulomatous skin disease with a high prevalence in the Amazon region. The Kaiabi Indians are an especially affected group. We studied the current epidemiologic and clinical progression of lobomycosis among the Kaiabi in Brazil, from initial case reports in 1965 through 2019. Read More

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An atypical keloid in a Brazilian man.

Med Sante Trop 2019 Nov;29(4):377-380

Service de dermatologie, Hôpital Andrée Rosemon, Cayenne, Guyane, EA 3593, Écosystèmes amazoniens et pathologies tropicales, Université de Guyane, Cayenne, Guyane.

Case report from French Guiana of an atypical keloid in a Brazilian man: Lobomycosis. Lobomycosis is a rare fungal skin infection, endemic to the Amazon basin. Its clinical manifestations are slow-growing keloid-like nodules, with a granulomatous reaction on histopathology. Read More

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November 2019

A case of disseminated paracoccidioidomycosis associated with cutaneous lobomycosis.

J Eur Acad Dermatol Venereol 2020 Jan 23;34(1):e18-e20. Epub 2019 Aug 23.

Service de Dermatologie, Centre Hospitalier Andrée Rosemon, Cayenne, France.

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January 2020

Comparative Innate and Adaptive Immune Responses in Atlantic Bottlenose Dolphins () With Viral, Bacterial, and Fungal Infections.

Front Immunol 2019 29;10:1125. Epub 2019 May 29.

Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Free-ranging Atlantic bottlenose dolphins ( = 360) from two southeastern U.S. estuarine sites were given comprehensive health examinations between 2003 and 2015 as part of a multi-disciplinary research project focused on individual and population health. Read More

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Role of social behaviour in the epidemiology of lobomycosis-like disease (LLD) in estuarine common bottlenose dolphins from Ecuador.

Dis Aquat Organ 2019 Apr;134(1):75-87

Pontificia Universidad Católica del Ecuador, 170143 Quito, Ecuador.

Lobomycosis-like disease (LLD) is a chronic granulomatous skin disorder that affects Delphinidae worldwide. LLD has been observed in common bottlenose dolphins Tursiops truncatus from the Gulf of Guayaquil, Ecuador, since 1990. Although exogenous factors such as salinity and pollution may play a role in the pathogenesis of this disease in estuarine and coastal dolphin communities, we hypothesized that demography and social behaviour may also influence its epidemiology. Read More

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Lobomycosis in Soldiers, Colombia.

Emerg Infect Dis 2019 04;25(4):654-660

Lobomycosis is a disease that is endemic to the Amazon rainforest and is caused by the still uncultured fungus Lacazia loboi. This disease occurs in loggers, farmers, miners, fishermen, and persons living near coastal rivers of this region. We report 6 soldiers in Colombia in whom lobomycosis developed after military service in the Amazon area. Read More

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Lobomycosis: a therapeutic challenge.

An Bras Dermatol 2018 03;93(2):279-281

Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Lobomycosis or lacaziosis is a chronic granulomatous fungal infection caused by Lacazia loboi. Most cases are restricted to tropical regions. Transmission is believed to occur through traumatic inoculation in the skin, mainly in exposed areas. Read More

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Lobomycosis-like disease in common bottlenose dolphins Tursiops truncatus from Belize and Mexico: bridging the gap between the Americas.

Dis Aquat Organ 2018 Mar;128(1):1-12

The Graduate Center, City University of New York, New York 10016, USA.

Lobomycosis and lobomycosis-like diseases (LLD) (also: paracoccidioidomycosis) are chronic cutaneous infections that affect Delphinidae in tropical and subtropical regions worldwide. In the Americas, these diseases have been relatively well-described, but gaps still exist in our understanding of their distribution across the continent. Here we report on LLD affecting inshore bottlenose dolphins Tursiops truncatus from the Caribbean waters of Belize and from the eastern tropical Pacific Ocean off the southwestern coast of Mexico. Read More

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Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela.

Am J Trop Med Hyg 2017 Dec 21;97(6):1757-1760. Epub 2017 Sep 21.

Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.

Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by , an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Read More

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December 2017

Health and Environmental Risk Assessment Project for bottlenose dolphins Tursiops truncatus from the southeastern USA. I. Infectious diseases.

Dis Aquat Organ 2017 Jul;125(2):141-153

Georgia Aquarium, 225 Baker Street, NW, Atlanta, Georgia 30313, USA.

From 2003 to 2015, 360 free-ranging Atlantic bottlenose dolphins Tursiops truncatus inhabiting the Indian River Lagoon (IRL, n = 246), Florida, and coastal waters of Charleston (CHS, n = 114), South Carolina, USA, were captured, given comprehensive health examinations, and released as part of a multidisciplinary and multi-institutional study of individual and population health. The aim of this review is to summarize the substantial health data generated by this study and to examine morbidity between capture sites and over time. The IRL and CHS dolphin populations are affected by complex infectious and neoplastic diseases often associated with immunologic disturbances. Read More

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Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.

Int J Dermatol 2017 Oct 3;56(10):1037-1045. Epub 2017 Jul 3.

Medicine School, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs.

Objectives: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses.

Methods: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. Read More

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October 2017

Keloids on the ears.

Int J Dermatol 2017 Aug 21;56(8):819-821. Epub 2017 Mar 21.

Dermatology service, Kennedy Hospital, Bogotá, Colombia.

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Granular cell differentiation: A review of the published work.

J Dermatol 2017 Mar;44(3):251-258

Boston University School of Medicine, Boston, Massachusetts, USA.

Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

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[Cancer and mycoses and literature review].

Authors:
M Develoux

Bull Soc Pathol Exot 2017 Feb 11;110(1):80-84. Epub 2017 Feb 11.

Service de parasitologie-mycologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.

Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Read More

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February 2017

Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis.

Emerg Infect Dis 2016 12;22(12):2063-2069

Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Read More

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December 2016

The cytotoxic T cells may contribute to the in situ immune response in Jorge Lobo's Disease human lesions.

Med Mycol 2017 Feb 25;55(2):145-149. Epub 2016 Aug 25.

Faculdade de Medicina, Universidade de São Paulo, Departamento de Patologia

Jorge Lobo's Disease (JLD) is a cutaneous chronic granulomatous disease caused by the pathogenic fungus Lacazia loboi. It is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. In order to contribute to the comprehension of immune mechanisms in JLD human lesions, we studied the cytotoxic immune response, focusing on TCD8+ and NK cells, and granzyme B. Read More

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February 2017

Toward the identification, characterization and experimental culture of Lacazia loboi from Atlantic bottlenose dolphin (Tursiops truncatus).

Med Mycol 2016 Aug 26;54(6):659-65. Epub 2016 Apr 26.

Harbor Branch Oceanographic Institute at Florida Atlantic University, Fort Pierce, FL.

Lobomycosis (lacaziosis) is a chronic, granulomatous, fungal infection of the skin and subcutaneous tissues of humans and dolphins. To date, the causative agent, the yeast-like organism Lacazia loboi, has not been grown in the laboratory, and there have been no recent reports describing attempts to culture the organism. As a result, studies on the efficacy of therapeutics and potential environmental reservoirs have not been conducted. Read More

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Detection of Multiple Budding Yeast Cells and a Partial Sequence of 43-kDa Glycoprotein Coding Gene of Paracoccidioides brasiliensis from a Case of Lacaziosis in a Female Pacific White-Sided Dolphin (Lagenorhynchus obliquidens).

Mycopathologia 2016 Aug 16;181(7-8):523-9. Epub 2016 Feb 16.

Laboratory of Aquatic Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Kyonan-Cho 1-7-1, Musashino, Tokyo, 180-8602, Japan.

Lacaziosis, formerly called as lobomycosis, is a zoonotic mycosis, caused by Lacazia loboi, found in humans and dolphins, and is endemic in the countries on the Atlantic Ocean, Indian Ocean and Pacific Ocean of Japanese coast. Susceptible Cetacean species include the bottlenose dolphin (Tursiops truncatus), the Indian Ocean bottlenose dolphin (T. aduncus), and the estuarine dolphin (Sotalia guianensis); however, no cases have been recorded in other Cetacean species. Read More

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Lacaziosis-like disease in Tursiops truncatus from Brazil: a histopathological and immunohistochemical approach.

Dis Aquat Organ 2016 Jan;117(3):229-35

Departamento de Patologia, Laboratório de Patologia Comparada de Animais Selvagens, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo (LAPCOM-VPT-FMVZ-USP), Cidade Universitária, São Paulo, SP 05508 270, Brazil.

Cetacean lacaziosis-like disease or lobomycosis-like disease (LLD) is a chronic skin condition caused by a non-cultivable yeast of the order Onygenales, which also includes Lacazia loboi, as well as Paracoccidioides brasiliensis and P. lutzii, respectively responsible for lacaziosis and paracoccidioidomycosis in humans. Complete identification and phylogenetic classification of the LLD etiological agent still needs to be elucidated, but preliminary phylogenetic analyses have shown a closer relationship of the LLD agent to Paracoccidioides spp. Read More

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January 2016

Analysis of Immune Response Markers in Jorge Lobo's Disease Lesions Suggests the Occurrence of Mixed T Helper Responses with the Dominance of Regulatory T Cell Activity.

PLoS One 2015 23;10(12):e0145814. Epub 2015 Dec 23.

Departamento de Patologia, Instituto Lauro de Souza Lima, Bauru, São Paulo, Brazil.

Jorge Lobo's disease (JLD) is a chronic infection that affects the skin and subcutaneous tissues. Its etiologic agent is the fungus Lacazia loboi. Lesions are classified as localized, multifocal, or disseminated, depending on their location. Read More

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THE RELEVANCE OF NUTRITIONAL STATUS AND HISTOPATHOLOGICAL FINDINGS ON THE INFECTIOUS PROCESS OF BALB/C MICE INOCULATED WITH Lacazia loboi.

Rev Inst Med Trop Sao Paulo 2015 Sep-Oct;57(5):421-6

Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, Universidade Estadual Paulista, Botucatu, SP, Brasil.

The aim of this study was to evaluate the effects of the protein-calorie malnutrition in BALB/c isogenic mice infected with Lacazia loboi, employing nutritional and histopathological parameters. Four groups were composed: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. Once malnutrition had been imposed, the animals were inoculated intradermally in the footpad and after four months, were sacrificed for the excision of the footpad, liver and spleen. Read More

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