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    132 results match your criteria Lobomycosis

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    Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela.
    Am J Trop Med Hyg 2017 Sep 25. Epub 2017 Sep 25.
    Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar, Italy.
    Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by Lacazia loboi, an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Read More

    Health and Environmental Risk Assessment Project for bottlenose dolphins Tursiops truncatus from the southeastern USA. I. Infectious diseases.
    Dis Aquat Organ 2017 Jul;125(2):141-153
    Georgia Aquarium, 225 Baker Street, NW, Atlanta, Georgia 30313, USA.
    From 2003 to 2015, 360 free-ranging Atlantic bottlenose dolphins Tursiops truncatus inhabiting the Indian River Lagoon (IRL, n = 246), Florida, and coastal waters of Charleston (CHS, n = 114), South Carolina, USA, were captured, given comprehensive health examinations, and released as part of a multidisciplinary and multi-institutional study of individual and population health. The aim of this review is to summarize the substantial health data generated by this study and to examine morbidity between capture sites and over time. The IRL and CHS dolphin populations are affected by complex infectious and neoplastic diseases often associated with immunologic disturbances. Read More

    Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.
    Int J Dermatol 2017 Oct 3;56(10):1037-1045. Epub 2017 Jul 3.
    Medicine School, Universidad Peruana Cayetano Heredia, Lima, Peru.
    Background: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs.

    Objectives: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses.

    Methods: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. Read More

    Granular cell differentiation: A review of the published work.
    J Dermatol 2017 Mar;44(3):251-258
    Boston University School of Medicine, Boston, Massachusetts, USA.
    Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

    [Cancer and mycoses and literature review].
    Bull Soc Pathol Exot 2017 Feb 11;110(1):80-84. Epub 2017 Feb 11.
    Service de parasitologie-mycologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.
    Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Read More

    Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis.
    Emerg Infect Dis 2016 12;22(12):2063-2069
    Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Read More

    The cytotoxic T cells may contribute to the in situ immune response in Jorge Lobo's Disease human lesions.
    Med Mycol 2017 Feb 25;55(2):145-149. Epub 2016 Aug 25.
    Faculdade de Medicina, Universidade de São Paulo, Departamento de Patologia
    Jorge Lobo's Disease (JLD) is a cutaneous chronic granulomatous disease caused by the pathogenic fungus Lacazia loboi. It is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. In order to contribute to the comprehension of immune mechanisms in JLD human lesions, we studied the cytotoxic immune response, focusing on TCD8+ and NK cells, and granzyme B. Read More

    Toward the identification, characterization and experimental culture of Lacazia loboi from Atlantic bottlenose dolphin (Tursiops truncatus).
    Med Mycol 2016 Aug 26;54(6):659-65. Epub 2016 Apr 26.
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Fort Pierce, FL.
    Lobomycosis (lacaziosis) is a chronic, granulomatous, fungal infection of the skin and subcutaneous tissues of humans and dolphins. To date, the causative agent, the yeast-like organism Lacazia loboi, has not been grown in the laboratory, and there have been no recent reports describing attempts to culture the organism. As a result, studies on the efficacy of therapeutics and potential environmental reservoirs have not been conducted. Read More

    Detection of Multiple Budding Yeast Cells and a Partial Sequence of 43-kDa Glycoprotein Coding Gene of Paracoccidioides brasiliensis from a Case of Lacaziosis in a Female Pacific White-Sided Dolphin (Lagenorhynchus obliquidens).
    Mycopathologia 2016 Aug 16;181(7-8):523-9. Epub 2016 Feb 16.
    Laboratory of Aquatic Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Kyonan-Cho 1-7-1, Musashino, Tokyo, 180-8602, Japan.
    Lacaziosis, formerly called as lobomycosis, is a zoonotic mycosis, caused by Lacazia loboi, found in humans and dolphins, and is endemic in the countries on the Atlantic Ocean, Indian Ocean and Pacific Ocean of Japanese coast. Susceptible Cetacean species include the bottlenose dolphin (Tursiops truncatus), the Indian Ocean bottlenose dolphin (T. aduncus), and the estuarine dolphin (Sotalia guianensis); however, no cases have been recorded in other Cetacean species. Read More

    Lacaziosis-like disease in Tursiops truncatus from Brazil: a histopathological and immunohistochemical approach.
    Dis Aquat Organ 2016 Jan;117(3):229-35
    Departamento de Patologia, Laboratório de Patologia Comparada de Animais Selvagens, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo (LAPCOM-VPT-FMVZ-USP), Cidade Universitária, São Paulo, SP 05508 270, Brazil.
    Cetacean lacaziosis-like disease or lobomycosis-like disease (LLD) is a chronic skin condition caused by a non-cultivable yeast of the order Onygenales, which also includes Lacazia loboi, as well as Paracoccidioides brasiliensis and P. lutzii, respectively responsible for lacaziosis and paracoccidioidomycosis in humans. Complete identification and phylogenetic classification of the LLD etiological agent still needs to be elucidated, but preliminary phylogenetic analyses have shown a closer relationship of the LLD agent to Paracoccidioides spp. Read More

    Analysis of Immune Response Markers in Jorge Lobo's Disease Lesions Suggests the Occurrence of Mixed T Helper Responses with the Dominance of Regulatory T Cell Activity.
    PLoS One 2015 23;10(12):e0145814. Epub 2015 Dec 23.
    Departamento de Patologia, Instituto Lauro de Souza Lima, Bauru, São Paulo, Brazil.
    Jorge Lobo's disease (JLD) is a chronic infection that affects the skin and subcutaneous tissues. Its etiologic agent is the fungus Lacazia loboi. Lesions are classified as localized, multifocal, or disseminated, depending on their location. Read More

    THE RELEVANCE OF NUTRITIONAL STATUS AND HISTOPATHOLOGICAL FINDINGS ON THE INFECTIOUS PROCESS OF BALB/C MICE INOCULATED WITH Lacazia loboi.
    Rev Inst Med Trop Sao Paulo 2015 Sep-Oct;57(5):421-6
    Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, Universidade Estadual Paulista, Botucatu, SP, Brasil.
    The aim of this study was to evaluate the effects of the protein-calorie malnutrition in BALB/c isogenic mice infected with Lacazia loboi, employing nutritional and histopathological parameters. Four groups were composed: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. Once malnutrition had been imposed, the animals were inoculated intradermally in the footpad and after four months, were sacrificed for the excision of the footpad, liver and spleen. Read More

    Epidemiology of lobomycosis-like disease in bottlenose dolphins Tursiops spp. from South America and southern Africa.
    Dis Aquat Organ 2015 Nov;117(1):59-75
    Cetacean Conservation Medicine Group (CMED), Peruvian Centre for Cetacean Research (CEPEC), Museo de Delfines, Pucusana, Peru.
    We report on the epidemiology of lobomycosis-like disease (LLD), a cutaneous disorder evoking lobomycosis, in 658 common bottlenose dolphins Tursiops truncatus from South America and 94 Indo-Pacific bottlenose dolphins T. aduncus from southern Africa. Photographs and stranding records of 387 inshore residents, 60 inshore non-residents and 305 specimens of undetermined origin (inshore and offshore) were examined for the presence of LLD lesions from 2004 to 2015. Read More

    Leprosy and Lobomycosis: First report from the Amazon Region.
    Lepr Rev 2015 Jun;86(2):195-201
    Leprosy is still a relevant health problem in Brazil with 31 044 new cases diagnosed in 2013, of which 781 new cases diagnosed in the State of Amazonas. Lobomycosis is a cutaneous-subcutaneous mycosis caused by Lacazia loboi, an in vitro uncultivable fungus. Lobomycosis has been mainly reported in the Amazon region of Brazil and Colombia affecting mainly male farmers and workers in extraction of rubber. Read More

    Jorge Lobo's disease.
    An Bras Dermatol 2015 Jul-Aug;90(4):586-8
    Universidade Federal de São Paulo, São Paulo, SP, BR.
    Jorge Lobo's Disease is a rare, chronic granulomatous cutaneous mycosis, which is typical of tropical and subtropical regions. It is caused by the traumatic implantation of the fungus Lacazia loboi into the skin and subcutaneous tissue. The disease was first described in 1931 by Jorge Lobo, in Recife (PE), Brazil. Read More

    Th17 and regulatory T cells contribute to the in situ immune response in skin lesions of Jorge Lobo's disease.
    Med Mycol 2016 Jan 1;54(1):23-8. Epub 2015 Sep 1.
    Universidade de São Paulo, Faculdade de Medicina, Laboratório da Disciplina de Patologia de Moléstias Transmissíveis, São Paulo, SP, Brasil.
    Jorge Lobo's disease (JLD) is a chronic granulomatous mycosis described in various Latin American countries. The main objective of the present study was to investigate the possible role of Th17 and Foxp3+ Treg cells in the pathogenesis of Jorge Lobo's disease. Human skin biopsies were submitted to an immunohistochemistry protocol to detect Foxp3, interleukin (IL)-1beta, CD25, IL-6, IL-17, and IL-23. Read More

    Mucocutaneous lesions in free-ranging Atlantic bottlenose dolphins Tursiops truncatus from the southeastern USA.
    Dis Aquat Organ 2015 Aug;115(3):175-84
    Georgia Aquarium, 225 Baker Street, NW, Atlanta, Georgia 30313, USA.
    Mucocutaneous lesions were biopsied from free-ranging Atlantic bottlenose dolphins Tursiops truncatus inhabiting the Indian River Lagoon (IRL), Florida, and estuarine waters of Charleston (CHS), South Carolina, USA, between 2003 and 2013. A total of 78 incisional biopsies from 58 dolphins (n=43 IRL, n=15 CHS) were examined. Thirteen dolphins had 2 lesions biopsied at the same examination, and 6 dolphins were re-examined and re-biopsied at time intervals varying from 1 to 8 yr. Read More

    Nutritional status and immune response in murine experimental Jorge Lobo's disease.
    Mycoses 2015 Sep 7;58(9):522-30. Epub 2015 Jul 7.
    Biology Technical Team, Instituto Lauro de Souza Lima, Bauru, Brazil.
    There are no studies investigating the role of nutritional status and immunity associated with Jorge Lobo's disease. The objective of this study was to evaluate the effects of protein-calorie malnutrition on the immune response of BALB/c mice inoculated with Lacazia loboi. In this study,the animals were divided into four groups: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. Read More

    A case of stranded Indo-Pacific bottlenose dolphin (Tursiops aduncus) with lobomycosis-like skin lesions in Kinko-wan, Kagoshima, Japan.
    J Vet Med Sci 2015 Aug 10;77(8):989-92. Epub 2015 May 10.
    Division of Vertebrate, Department of Zoology, National Museum of Nature and Science 4-1-1 Amakubo, Tsukuba-shi, Ibaraki 305-0005, Japan.
    Lobomycosis is a chronic fungal disease caused by the etiologic agent, Lacazia loboi, in the skin and subcutaneous tissues in humans and dolphins in tropical and transitional tropical climates. An Indo-Pacific bottlenose dolphin (Tursiops aduncus) stranded in Kagoshima, Japan, had severe skin lesions characterized by granulomatous reactions and hyperkeratosis that were similar to those of the lobomycosis, but no fungal organism was observed in the skin lesion. In this paper, we report a stranded Indo-Pacific bottlenose dolphin with lobomycosis-like lesions based on pathological examinations in Japan. Read More

    Lacaziosis - unusual clinical presentation.
    An Bras Dermatol 2015 Mar-Apr;90(2):268-9
    Fundação Alfredo da Matta, Manaus, AM, Brazil.
    Lacaziosis or Jorge Lobo's disease is a fungal, granulomatous, chronic infectious disease caused by Lacazia loboi, which usually affects the skin and subcutaneous tissue. It is characterized by slow evolution and a variety of cutaneous manifestations with the most common clinical expression being nodular keloid lesions that predominate in exposed areas. We report the case of a patient who had an unusual clinical presentation, with a single-plated lesion on the back. Read More

    Study of murine experimental Jorge Lobo's disease by analysis of peritoneal lavage cells and footpad histopathology: early versus chronic lesions.
    Med Mycol 2015 May 27;53(4):378-86. Epub 2015 Feb 27.
    Equipe Técnia de Microbiologia, Instituto Lauro de Souza Lima, Bauru, SP, Brazil.
    The murine model of Jorge Lobo's disease is characterized by histological alterations similar to those seen in human disease, including a large number of viable fungi. This study evaluated the immune response of mice with early and late macroscopic lesions (5 and 13 months post-inoculation [p.i. Read More

    Subcutaneous mycoses: an aetiological study of 15 cases in a tertiary care hospital at Dibrugarh, Assam, northeast India.
    Mycopathologia 2015 Jun 18;179(5-6):425-35. Epub 2015 Jan 18.
    Department of Microbiology, Assam Medical College and Hospital, Dibrugarh, 786002, Assam, India.
    Subcutaneous mycoses are a group of fungal infections of dermis and subcutaneous tissue which consist of sporotrichosis, chromoblastomycosis, phaeohyphomycosis, hyalohyphomycosis, mycetoma, subcutaneous zygomycosis, rhinosporidiosis, lobomycosis and disseminated penicilliosis. A total of 46 consecutive patients with clinically suspected subcutaneous mycoses attending various departments of Assam Medical College and Hospital were included in this prospective study to know the prevalence of subcutaneous mycoses in this eastern part of Assam. Direct microscopy in 10 and 40 % KOH, histopathological examination of biopsied tissue, colony characteristics on Sabourauds dextrose agar media both at 25 and 37 °C and detailed morphology of each fungus on lactophenol cotton blue mount were the basis of identification of the fungi. Read More

    Disseminated infection with Lacazia loboi and immunopathology of the lesional spectrum.
    Hum Pathol 2015 Feb 12;46(2):334-8. Epub 2014 Nov 12.
    Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Pará, 66087-670, Belem, PA, Brazil; Nucleo de Medicina Tropical, Universidade Federal do Pará, 66015-070, Belem, PA, Brazil.
    The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followed by CD45RO(+), CD4(+), and CD8(+) T cells; CD57(+) natural killer cells; S-100(+) cells; and CD20(+) B lymphocytes. A 54-year-old man and living in the State of Para, Amazon region, Brazil, was seen with a lesion on the left lower limb, which had started as a small nodular area 18 years ago. Read More

    Jorge Lobo's disease: immunohistochemical characterization of dendritic cells in cutaneous lesions.
    Mycopathologia 2015 Apr 7;179(3-4):269-74. Epub 2014 Dec 7.
    Instituto de Assistência Médica ao Servidor Público Estadual, Programa de pós-graduação em Ciências da Saúde, São Paulo, SP, Brazil.
    Background: Jorge Lobo's disease (JLD) is a cutaneous chronic mycosis caused by Lacazia loboi. We studied Factor XIIIa + dermal dendrocytes (FXIIIa + DD), Langerhans cells (LC) through the expression of langerin and the expression of S100 protein.

    Methods: A total of 41 biopsies and 10 normal skins (control) were developed with a polymer-based immunohistochemical method. Read More

    Jorge Lobo's disease: a case of keloidal blastomycosis (lobomycosis) in a nonendemic area.
    Ther Adv Infect Dis 2014 Jun;2(3-4):91-6
    Director, Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, The Brooklyn Hospital Center, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.
    Lobomycosis or lacaziosis is a chronic subcutaneous fungal infection, caused by the fungus Lacazia loboi, which is phylogenetically related to Coccidioides, Blastomyces, Histoplasma, and Paracoccidioides. The disease was first recognized in 1931 by Jorge Lobo, who found the disease to be a keloidal blastomycosis and named it Jorge Lobo's disease. This case was perplexing initially as this fungal infection is very uncommon in the USA. Read More

    Analysis of microvasculature phenotype and endothelial activation markers in skin lesions of lacaziosis (Lobomycosis).
    Microb Pathog 2015 Jan 20;78:29-36. Epub 2014 Nov 20.
    Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
    Jorge Lobo's disease is a rare mycosis characterized by chronic inflammation, which causes skin lesions in the absence of visceral dissemination. The disease occurs mainly in hot and humid climates and most cases have been registered in the Brazilian Amazon region. This study investigated possible microvascular alterations in skin lesions caused by infection with Lacazia loboi which may interfere with the clinical progression of the disease. Read More

    Lobomycosis: epidemiology, clinical presentation, and management options.
    Ther Clin Risk Manag 2014 9;10:851-60. Epub 2014 Oct 9.
    Department of Dermatology, Tropical Medicine Foundation Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
    Lobomycosis is a subcutaneous mycosis of chronic evolution caused by the Lacazia loboi fungus. Its distribution is almost exclusive in the Americas, and it has a particularly high prevalence in the Amazon basin. Cases of lobomycosis have been reported only in dolphins and humans. Read More

    [Paracoccidioidomycosis of the external ear].
    Ann Dermatol Venereol 2014 Aug-Sep;141(8-9):514-7. Epub 2014 Jun 3.
    Service de dermatologie, centre hospitalier de Cayenne, BP 6006, 97300 Cayenne, Guyane; EA 3593-EPaT, université des Antilles et de la Guyane, BP 6006, Cayenne, Guyane. Electronic address:
    Background: Paracoccidioidomycosis is a systemic fungal infection common in Latin America. Cutaneous involvement is frequent and usually affects multiple sites, being most frequently associated with lesions of the oropharyngeal mucosa. The cutaneous form on its own is rare. Read More

    A systematic health assessment of indian ocean bottlenose (Tursiops aduncus) and indo-pacific humpback (Sousa plumbea) dolphins incidentally caught in shark nets off the KwaZulu-Natal Coast, South Africa.
    PLoS One 2014 9;9(9):e107038. Epub 2014 Sep 9.
    South African Institute for Aquatic Biodiversity, c/o Port Elizabeth Museum/Bayworld, Port Elizabeth, South Africa.
    Coastal dolphins are regarded as indicators of changes in coastal marine ecosystem health that could impact humans utilizing the marine environment for food or recreation. Necropsy and histology examinations were performed on 35 Indian Ocean bottlenose dolphins (Tursiops aduncus) and five Indo-Pacific humpback dolphins (Sousa plumbea) incidentally caught in shark nets off the KwaZulu-Natal coast, South Africa, between 2010 and 2012. Parasitic lesions included pneumonia (85%), abdominal and thoracic serositis (75%), gastroenteritis (70%), hepatitis (62%), and endometritis (42%). Read More

    Morphological findings of deep cutaneous fungal infections.
    Am J Dermatopathol 2014 Jul;36(7):531-53; quiz 554-6
    *Consultant Histopathologist, Dermatopathology and Lymphoid Area, Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain; †Dermatologist, Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INER/CIENI, Hospital Angeles Lomas, Centro Medico ABC, Huixquilucan, México; and ‡Dermatologist and Mycologist, Hospital General Dr. Manuel Gea Gonzalez, Mexico City, México.
    Cutaneous fungal infections used to be rare in most developed countries. However, they have become more common due to immunosuppression and globalization. In this report, we summarize the histopathologic findings of the main cutaneous fungal infections that are commonly seen in daily practice, including eumycetoma, sporotrichosis, histoplasmosis, cryptococcosis, coccidioidomycosis, aspergillosis, zygomycosis, phaeohyphomycosis, alternariosis, blastomycosis, paracoccidioidomycosis, lobomycosis, and chromoblastomycosis. Read More

    Plasmacytoid dendritic cells in cutaneous lesions of patients with chromoblastomycosis, lacaziosis, and paracoccidioidomycosis: a comparative analysis.
    Med Mycol 2014 May 28;52(4):397-402. Epub 2014 Apr 28.
    Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia.
    Plasmacytoid dendritic cells (pDCs) are characterized by expression of CD123 and BDCA-2 (Blood Dendritic Cell Antigen 2) (CD303) molecules, which are important in innate and adaptive immunity. Chromoblastomycosis (CBM), lacaziosis or Jorge Lobo's disease (JLD), and paracoccidioidomycosis (PCM), are noteworthy in Latin America due to the large number of reported cases. The severity of lesions is mainly determined by the host's immune status and in situ responses. Read More

    Lacaziosis-like disease among bottlenose dolphins Tursiops truncatus photographed in Golfo Dulce, Costa Rica.
    Dis Aquat Organ 2014 Jan;107(3):173-80
    Joyce Corrigan Memorial Care Center, Phoenix Zoo, Phoenix, Arizona 85008, USA.
    Lacaziosis (also known as lobomycosis) is a chronic dermal disease caused by the fungal agent Lacazia loboi, which affects both humans and dolphins. Photographic data have been used to identify lacaziosis-like disease (LLD) among dolphins in the waters of North and South America, and here we report LLD in bottlenose dolphins Tursiops truncatus off the coast of Costa Rica, the first reporting in Central American waters. During the periods of 1991 to 1992 and 2010 to 2011, 3 research teams conducted separate dolphin surveys in the Pacific tropical fiord Golfo Dulce, and each documented skin lesions in the resident population of bottlenose dolphins. Read More

    Guiana dolphins (Sotalia guianensis) as marine ecosystem sentinels: ecotoxicology and emerging diseases.
    Rev Environ Contam Toxicol 2014 ;228:1-29
    PPG em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública/FIOCRUZ & Grupo de Estudos de Mamíferos Marinhos da Região dos Lagos - GEMM-Lagos, Rua Leopoldo Bulhões, 1.480 - 6° andar, sala 611, Manguinhos, 21041-210, Rio de Janeiro, RJ, Brazil,
    Guiana dolphins (Sotalia guianensis) are small cetaceans that inhabit coastal regions down to a 50 m depth. As a coastally distributed species, they are exposed to a variety of human-induced risks that include passive fishing nets, persistent environmental pollution, and emerging diseases. As a top predatorS. Read More

    Lobomycosis: risk of zoonotic transmission from dolphins to humans.
    Vector Borne Zoonotic Dis 2013 Oct 6;13(10):689-93. Epub 2013 Aug 6.
    1 College of Veterinary Medicine and Biomedical Sciences, Colorado State University , Fort Collins, Colorado.
    Lobomycosis, a fungal disease of the skin and subcutaneous tissues caused by Lacazia loboi, is sometimes referred to as a zoonotic disease because it affects only specific delphinidae and humans; however, the evidence that it can be transferred directly to humans from dolphins is weak. Dolphins have also been postulated to be responsible for an apparent geographic expansion of the disease in humans. Morphological and molecular differences between the human and dolphin organisms, differences in geographic distribution of the diseases between dolphins and humans, the existence of only a single documented case of presumed zoonotic transmission, and anecdotal evidence of lack of transmission to humans following accidental inoculation of tissue from infected dolphins do not support the hypothesis that dolphins infected with L. Read More

    Lobomycosis and squamous cell carcinoma.
    An Bras Dermatol 2013 Mar-Apr;88(2):293-5
    Tropical Medicine Foundation of the Amazonas, Manaus, (AM), Brazil.
    The occurence of squamous cell carcinoma on long-lasting ulcers is classic. Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents. Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported. Read More

    Lobomycosis successfully treated with posaconazole.
    Am J Trop Med Hyg 2013 Jun 1;88(6):1207-8. Epub 2013 Apr 1.
    Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru.
    Lobomycosis is a chronic subcutaneous mycosis for which no standard treatment is available to date. We describe a patient in Peru with lobomycosis on the left earlobe that was successfully treated with posaconazole for 27 months. No evidence of recurrence was observed after five years of follow-up. Read More

    Lobomycosis: A case from Southeastern Europe and review of the literature.
    J Dermatol Case Rep 2012 Sep;6(3):65-9
    2nd Department of Dermatology, Athens University School of Medicine, Attikon General University Hospital, Chaidari, Athens, Greece.
    Background: Lobomycosis, also known as Jorge Lobo's disease, represents a rare chronic subcutaneous mycosis caused by the fungus Lacazia loboi, an organism that is found within lesions but has not been cultured to date. The natural reservoir of L. loboi is unknown but it is believed to be aquatic, or associated with soil and vegetation. Read More

    Lobomycosis.
    Clin Dermatol 2012 Jul-Aug;30(4):420-4
    Faculty of Medicine, Nilton Liins University, Av. Professor Nilton Lins 3259, Parque das Laranjeiras, Manaus, Amazonas, Brazil.
    Lobomycosis is a rare chronic fungal infection of the subcutaneous tissue found in South America, mainly in Brazil. It is caused by Lacazia loboi. Its clinical manifestations are dermal nodules, either lenticular or in plaques, and keloidlike lesions that can resemble nodular leprosy or leishmaniasis, other subcutaneous mycoses (sporotrychosis, chromomycosis, paracoccidioidomycosis), keloids, and malignant tumors. Read More

    Lobomycosis: an emerging disease in humans and delphinidae.
    Mycoses 2012 Jul 19;55(4):298-309. Epub 2012 Mar 19.
    Department of Dermatology, Tufts Medical Center and Miraca Life Sciences, Boston, MA 02111, USA.
    Lobomycosis, a disease caused by the uncultivable dimorphic onygenale fungi Lacazia loboi, remains to date as an enigmatic illness, both due to the impossibility of its aetiological agent to be cultured and grown in vitro, as well as because of its unresponsiveness to specific antifungal treatments. It was first described in the 1930s by Brazilian dermatologist Jorge Lobo and is known to cause cutaneous and subcutaneous localised and widespread infections in humans and dolphins. Soil and vegetation are believed to be the chief habitat of the fungus, however, increasing reports in marine mammals has shifted the attention to the aquatic environment. Read More

    [Current epidemiology and laboratory diagnosis of endemic mycoses in Spain].
    Enferm Infecc Microbiol Clin 2012 Aug 29;30(7):407-13. Epub 2011 Nov 29.
    Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
    Histoplasmosis and paracoccidioidomycosis are emerging infections in Spain associated with immigration and travelling. In last three decades a total of 128 cases of histoplasmosis have been reported in Spain, 59 in travellers, 63 in immigrants, three associated to drug abuse, two in laboratory workers, and one in a solid organ transplant receptor. In 1969 the first Spanish case of paracoccidioidomycosis was published and a total of 21 cases have been reported so far. Read More

    Advances in tropical diseases.
    G Ital Dermatol Venereol 2011 Oct;146(5):353-71
    Department of Dermatology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    There are six diseases that WHO considers as the major threat in developing countries, leprosy, filariasis, malaria, schistosomiasis, Chagas disease and leishmaniasis; and of these only malaria does not present skin lesions. These diseases are among the so called tropical diseases found in countries of tropical climate, usually infections and infestations considered exotic and rare in European and North American countries. It is extremely important for doctors of all countries to be able to provide correct pre travel counseling and to make early diagnosis and treatment, thus avoiding dissemination of these dieases to non endemic areas. Read More

    Molecular diagnosis of lobomycosis-like disease in a bottlenose dolphin in captivity.
    Med Mycol 2012 Jan 15;50(1):106-9. Epub 2011 Aug 15.
    Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain.
    We report the diagnosis and molecular characterization of lobomycosis-like lesions in a captive bottlenose dolphin. The clinical picture and the absence of growth in conventional media resembled the features associated with Lacazia loboi. However sequencing of ribosomal DNA and further phylogenetic analyses showed a novel sequence more related to Paracoccidioides brasilensis than to L. Read More

    Lacaziosis and lacaziosis-like prevalence among wild, common bottlenose dolphins Tursiops truncatus from the west coast of Florida, USA.
    Dis Aquat Organ 2011 May;95(1):49-56
    Division of Biostatistics and Epidemiology, Department of Medicine, Medical University of South Carolina, 135 Cannon St. Suite 303., Charleston, South Carolina 29425, USA.
    Lacaziosis (lobomycosis; Lacazia loboi) is a fungal skin disease that naturally occurs only in humans and dolphins. The first reported case of lacaziosis in a bottlenose dolphin Tursiops truncatus occurred in 1970 in Sarasota Bay, Florida, USA, and subsequent photo-ID monitoring of the Sarasota Bay dolphin population has revealed persistence of the disease. The objectives of this study were to estimate lacaziosis prevalence (P) in 2 bottlenose dolphin populations on the west coast of Florida (Sarasota Bay and Charlotte Harbor) and compare disease occurrence to other published estimates of lacaziosis in dolphin populations across the globe. Read More

    Jorge Lobo's disease with restricted labial presentation.
    An Bras Dermatol 2011 Mar-Apr;86(2):373-4
    Programa Health Sciences Institute, Federal University of Pará, Brasil.
    Jorge Lobo's Disease (JLD) is a chronic granulomatous cutaneous mycosis caused by Lacazia loboi. The most typical lesions are keloid-like growths preferentially located on limbs and ears. To the best of the authors' knowledge, only one labial case has previously been reported. Read More

    Lobomycosis-like disease in wild bottlenose dolphins Tursiops truncatus of Laguna, southern Brazil: monitoring of a progressive case.
    Dis Aquat Organ 2011 Jan;93(2):163-70
    Departamento de Ecologia e Zoologia, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil.
    Lobomycosis is a chronic dermal infection affecting humans and small cetaceans. In 1993, a study identified the presence of the etiologic agent of lobomycosis in a resident population of Tursiops truncatus (bottlenose dolphin) in Laguna, Brazil. Until now, no additional information relating to the persistence or prevalence of this pathogen in this population has been available. Read More

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