157 results match your criteria Lobomycosis


Lobomycosis Epidemiology and Management: The Quest for a Cure for the Most Neglected of Neglected Tropical Diseases.

J Fungi (Basel) 2022 May 10;8(5). Epub 2022 May 10.

Graduate Research and Innovation Program, Centro Universitario FMABC, Santo André 09060-870, SP, Brazil.

Lobomycosis is a chronic disease caused by , which is endemic to the Amazon rainforest, where it affects forest dwellers in Brazil. There is no disease control program and no official therapeutic protocol. This situation contributes to an unknown disease prevalence and unmet needs of people disabled by this disease who seek access to treatment. Read More

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Lobomycosis and paracoccidioidomycosis meet again.

Rev Iberoam Micol 2022 Mar 10. Epub 2022 Mar 10.

Veterinary Mycology Group, Department of Animal Health and Anatomy, Veterinary School, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

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Jorge Lobo's disease with malignant degeneration to squamous cell carcinoma: case report.

An Bras Dermatol 2022 Jan-Feb;97(1):93-95. Epub 2021 Nov 23.

Service of Dermatology, Universidade Federal do Pará, Belém, PA, Brazil.

Jorge Lobo's disease (JLD) is a chronic, granulomatous fungal infection caused by the traumatic implantation of the fungus Lacazia loboi in the cutaneous and subcutaneous tissues, with the presence of isolated nodular and coalescent keloidal lesions. Malignant degeneration is rare. This case report describes a 64-year-old male patient with JLD for 30-years who showed a change in the aspect of a lesion in the left lower limb. Read More

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January 2022

Lobomycosis: exuberant presentation with malignant transformation.

An Bras Dermatol 2021 Nov-Dec;96(6):762-764. Epub 2021 Sep 25.

Fundação de Dermatologia Tropical Heitor Vieira Dourado, Manaus, AM, Brazil.

Lobomycosis is a chronic granulomatous infection caused by the yeast Lacazia loboi, typically found in tropical and subtropical geographical areas. Transmission occurs through traumatic inoculation into the skin, especially in exposed areas, of men who work in contact with the soil. Lesions are restricted to the skin and subcutaneous tissue, with a keloid-like appearance in most cases. Read More

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November 2021

Extensive, multifocal lobomycosis.

J Cutan Pathol 2021 Aug 11. Epub 2021 Aug 11.

Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, San Antonio, Texas, USA.

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An 18-year-old man with tropical verrucous syndrome: Leishmaniasis or sporotrichosis?

Biomedica 2021 06 29;41(2):240-246. Epub 2021 Jun 29.

Hospital Universitario Centro Dermatológico Federico Lleras Acosta, Bogotá, D.C., Colombia; Universidad de La Sabana, Chía, Colombia.

The tropical verrucous syndrome includes infectious, chronic, and granulomatous skin conditions appearing with plaques, nodules, or ulcers with a warty surface which gives name to the syndrome. It includes forms of chromoblastomycosis, sporotrichosis, paracoccidioidomycosis, lobomycosis, leishmaniasis, and tuberculosis verrucosa cutis with ample distribution in tropical and subtropical areas. The diagnoses may be difficult and confused among them, especially between sporotrichosis and leishmaniasis. Read More

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Posaconazole for lobomycosis.

Braz J Infect Dis 2021 Mar-Apr;25(2):101576. Epub 2021 Apr 12.

Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, RS Brazil.

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A global view on fungal infections in humans and animals: infections caused by dimorphic fungi and dermatophytoses.

J Appl Microbiol 2021 Dec 13;131(6):2688-2704. Epub 2021 Apr 13.

Faculty of Biological Sciences, Department of Mycology and Genetics, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland.

Fungal infections are still underappreciated and their prevalence is underestimated, which renders them a serious public health problem. Realistic discussions about their distribution, symptoms, and control can improve management and diagnosis and contribute to refinement of preventive actions using currently available tools. This article represents an overview of dermatophytes and endemic fungi that cause infections in humans and animals. Read More

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December 2021

Subcutaneous Mycoses in Travelers.

Curr Trop Med Rep 2020 Dec 6;7(4):141-152. Epub 2020 Nov 6.

Dermatology Service & Micology Department, Hospital General de México "Dr Eduardo Liceaga", Dr. Balmis 148, colonia Doctores, PZ: 06720 Mexico City, Mexico.

Purpose Of Review: The increase in international travel in recent decades has contributed to the risk of acquiring diseases considered endemic to a region or country and the change in the epidemiology of these diseases. Endemic mycoses that may be acquired by travelers in the short or long term are endemic subcutaneous mycoses such as sporotrichosis and lobomycosis, while endemic systemic mycoses are a group of serious diseases including histoplasmosis and coccidioidomycosis. Herein, we review the current knowledge and highlight the most important aspects of these fungal infections in travelers. Read More

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December 2020

Multidrug Therapy for Leprosy Can Cure Patients with Lobomycosis in Acre State, Brazil: A Proof of Therapy Study.

Am J Trop Med Hyg 2020 11 16;104(2):634-639. Epub 2020 Nov 16.

1Setor de Pós-graduação, Pesquisa e Inovação, Centro Universitário Saúde ABC, Fundação ABC, Santo André, Brazil.

Lobomycosis, also referred to as lacaziosis, is an endemic cutaneous and subcutaneous fungal disease that mainly affects Amazonian forest dwellers in Brazil. There is no disease control program in place in Brazil, and antifungal therapy failures are common, and the therapy is inaccessible to most patients. We performed a randomized, unblinded clinical trial testing the cure rate of multiple drug therapy (MDT) for leprosy with surgical excision, with or without itraconazole. Read More

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November 2020

Comparative effect of osmium tetroxide and ruthenium tetroxide on Lacazia loboi ultrastructure.

Microsc Res Tech 2021 Apr 11;84(4):789-795. Epub 2020 Nov 11.

Grupo de Morfología Celular, Dirección de Investigación en Salud Pública, Instituto Nacional de Salud, Bogotá, Colombia.

Lobomycosis is a skin infection produced by the fungus Lacazia loboi, which mainly affects some indigenous and afro-descendant populations in Tropical America. We previously reported the comparative effect of osmium tetroxide (OsO ) and ruthenium tetroxide (RuO ) in the electron microscopy (EM) of other related microorganisms. The objective of this study is to compare the effect of postfixation with OsO and RuO in the ultrastructure of L. Read More

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Lacaziosis: immunohistochemical evaluation of elements of the humoral response in cutaneous lesions.

Rev Inst Med Trop Sao Paulo 2020 9;62:e75. Epub 2020 Oct 9.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.

Lacaziosis is a cutaneous mycosis caused by the fungus Lacazia loboi, described in different countries of Latin America and prevalent in the Amazon region. The ineffective immune response against the agent seems to be related to a Th2 pattern of cytokines. There are few reports exploring elements of the humoral response in these lesions. Read More

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October 2020

Lacaziosis (Lobomycosis) From Southern Mexico: A Case Confirmed by Molecular Biology.

Mycopathologia 2020 08 7;185(4):737-739. Epub 2020 Jun 7.

Dermatology Department and Laboratory of Mycology, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.

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M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis.

Mycopathologia 2020 Jun 6;185(3):477-483. Epub 2020 May 6.

Laboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil.

Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. Read More

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What is your diagnosis? Keloidal cord-like lesion on the leg.

An Bras Dermatol 2020 May - Jun;95(3):386-389. Epub 2020 Mar 19.

Department of Dermatopathology, Fundação Alfredo da Matta de Dermatologia e Venereologia, Manaus, AM, Brazil.

We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. Read More

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Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965-2019.

Emerg Infect Dis 2020 05;26(5):930-936

Lobomycosis is a rare granulomatous skin disease with a high prevalence in the Amazon region. The Kaiabi Indians are an especially affected group. We studied the current epidemiologic and clinical progression of lobomycosis among the Kaiabi in Brazil, from initial case reports in 1965 through 2019. Read More

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An atypical keloid in a Brazilian man.

Med Sante Trop 2019 Nov;29(4):377-380

Service de dermatologie, Hôpital Andrée Rosemon, Cayenne, Guyane, EA 3593, Écosystèmes amazoniens et pathologies tropicales, Université de Guyane, Cayenne, Guyane.

Case report from French Guiana of an atypical keloid in a Brazilian man: Lobomycosis. Lobomycosis is a rare fungal skin infection, endemic to the Amazon basin. Its clinical manifestations are slow-growing keloid-like nodules, with a granulomatous reaction on histopathology. Read More

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November 2019

A case of disseminated paracoccidioidomycosis associated with cutaneous lobomycosis.

J Eur Acad Dermatol Venereol 2020 Jan 23;34(1):e18-e20. Epub 2019 Aug 23.

Service de Dermatologie, Centre Hospitalier Andrée Rosemon, Cayenne, France.

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January 2020

Comparative Innate and Adaptive Immune Responses in Atlantic Bottlenose Dolphins () With Viral, Bacterial, and Fungal Infections.

Front Immunol 2019 29;10:1125. Epub 2019 May 29.

Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Free-ranging Atlantic bottlenose dolphins ( = 360) from two southeastern U.S. estuarine sites were given comprehensive health examinations between 2003 and 2015 as part of a multi-disciplinary research project focused on individual and population health. Read More

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Role of social behaviour in the epidemiology of lobomycosis-like disease (LLD) in estuarine common bottlenose dolphins from Ecuador.

Dis Aquat Organ 2019 Apr;134(1):75-87

Pontificia Universidad Católica del Ecuador, 170143 Quito, Ecuador.

Lobomycosis-like disease (LLD) is a chronic granulomatous skin disorder that affects Delphinidae worldwide. LLD has been observed in common bottlenose dolphins Tursiops truncatus from the Gulf of Guayaquil, Ecuador, since 1990. Although exogenous factors such as salinity and pollution may play a role in the pathogenesis of this disease in estuarine and coastal dolphin communities, we hypothesized that demography and social behaviour may also influence its epidemiology. Read More

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Lobomycosis in Soldiers, Colombia.

Emerg Infect Dis 2019 04;25(4):654-660

Lobomycosis is a disease that is endemic to the Amazon rainforest and is caused by the still uncultured fungus Lacazia loboi. This disease occurs in loggers, farmers, miners, fishermen, and persons living near coastal rivers of this region. We report 6 soldiers in Colombia in whom lobomycosis developed after military service in the Amazon area. Read More

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Lobomycosis: a therapeutic challenge.

An Bras Dermatol 2018 03;93(2):279-281

Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Lobomycosis or lacaziosis is a chronic granulomatous fungal infection caused by Lacazia loboi. Most cases are restricted to tropical regions. Transmission is believed to occur through traumatic inoculation in the skin, mainly in exposed areas. Read More

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Lobomycosis-like disease in common bottlenose dolphins Tursiops truncatus from Belize and Mexico: bridging the gap between the Americas.

Dis Aquat Organ 2018 Mar;128(1):1-12

The Graduate Center, City University of New York, New York 10016, USA.

Lobomycosis and lobomycosis-like diseases (LLD) (also: paracoccidioidomycosis) are chronic cutaneous infections that affect Delphinidae in tropical and subtropical regions worldwide. In the Americas, these diseases have been relatively well-described, but gaps still exist in our understanding of their distribution across the continent. Here we report on LLD affecting inshore bottlenose dolphins Tursiops truncatus from the Caribbean waters of Belize and from the eastern tropical Pacific Ocean off the southwestern coast of Mexico. Read More

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Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela.

Am J Trop Med Hyg 2017 Dec 21;97(6):1757-1760. Epub 2017 Sep 21.

Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.

Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by , an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Read More

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December 2017

Health and Environmental Risk Assessment Project for bottlenose dolphins Tursiops truncatus from the southeastern USA. I. Infectious diseases.

Dis Aquat Organ 2017 Jul;125(2):141-153

Georgia Aquarium, 225 Baker Street, NW, Atlanta, Georgia 30313, USA.

From 2003 to 2015, 360 free-ranging Atlantic bottlenose dolphins Tursiops truncatus inhabiting the Indian River Lagoon (IRL, n = 246), Florida, and coastal waters of Charleston (CHS, n = 114), South Carolina, USA, were captured, given comprehensive health examinations, and released as part of a multidisciplinary and multi-institutional study of individual and population health. The aim of this review is to summarize the substantial health data generated by this study and to examine morbidity between capture sites and over time. The IRL and CHS dolphin populations are affected by complex infectious and neoplastic diseases often associated with immunologic disturbances. Read More

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Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.

Int J Dermatol 2017 Oct 3;56(10):1037-1045. Epub 2017 Jul 3.

Medicine School, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs.

Objectives: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses.

Methods: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. Read More

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October 2017

Keloids on the ears.

Int J Dermatol 2017 Aug 21;56(8):819-821. Epub 2017 Mar 21.

Dermatology service, Kennedy Hospital, Bogotá, Colombia.

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Granular cell differentiation: A review of the published work.

J Dermatol 2017 Mar;44(3):251-258

Boston University School of Medicine, Boston, Massachusetts, USA.

Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

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[Cancer and mycoses and literature review].

Authors:
M Develoux

Bull Soc Pathol Exot 2017 Feb 11;110(1):80-84. Epub 2017 Feb 11.

Service de parasitologie-mycologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.

Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Read More

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February 2017