10,574 results match your criteria Lobar Atelectasis Imaging
Acta Neurol Belg 2018 Dec 11. Epub 2018 Dec 11.
Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.
Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to analyze SAHE on MRI in the acute and subacute phase of LH in patients with and without associated hemorrhagic features supportive of CAA (i. Read More
J Cardiol Cases 2012 Feb 21;5(1):e39-e43. Epub 2011 Nov 21.
Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
Background: We report a rare case of acute pulmonary embolism (PE) induced by urinary retention and bladder distention with benign prostatic hyperplasia (BPH).
Case Report: A 76-year-old male with BPH presented to the hospital with anuria of 24 h duration and abdominal distention. Physical examination revealed tenderness and distention of the lower abdomen and a swollen right leg. Read More
Am J Ind Med 2018 Dec 10. Epub 2018 Dec 10.
Alcoa Corporation, Pittsburgh, Pennsylvania.
Background: Lobar pneumonia is an occupational disease of welders. This is the first report of global deployment of a pneumococcal vaccination program for welders within a multi-national corporation.
Methods: Global webinars were conducted to introduce the program. Read More
Transplant Direct 2018 Nov 12;4(11):e398. Epub 2018 Oct 12.
Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: Early diagnosis of unilateral chronic lung allograft dysfunction (CLAD) is difficult because the unaffected contralateral lung functions as a reservoir in bilateral living-donor lobar lung transplantation (LDLLT). We previously reported the usefulness of Xe ventilation scintigraphy for detection of unilateral change, but the supply of Xe has been stopped globally. The present study aimed to examine the usefulness of inspiratory and expiratory computed tomography (I/E CT) volumetry for detection of unilateral change in CLAD patients. Read More
Clin Neurol Neurosurg 2018 Dec 1;176:67-72. Epub 2018 Dec 1.
Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria, CHLN, Lisboa, Portugal; EEG/Sleep Laboratory, Hospital de Santa Maria, CHLN, Lisboa, Portugal; Faculty of Medicine, University of Lisbon, Lisboa, Portugal.
Objectives: The association between short-term ambient particulate matter ≤ 2.5 μm diameter (PM2.5) and spontaneous intracerebral hemorrhage (SICH) occurrence is unclear. Read More
Chest 2018 Dec 5. Epub 2018 Dec 5.
Pulmonary & Critical Care Medicine Divisions, Regions Hospital & University of Minnesota, Minneapolis/ St. Paul MN, USA. Electronic address:
Lobar atelectasis (or collapse) is an exceedingly common, rather predictable and potentially pathogenic companion to many forms of acute illness, post-operative care, and chronic debility. Readily diagnosed by routine chest imaging and bedside ultrasound, the consequences from lobar collapse may be minor or serious, depending on extent, mechanism, patient vulnerability, abruptness of onset, effectiveness of hypoxic vasoconstriction and compensatory reserves. Measures taken to reduce secretion burden, assure adequate secretion clearance, maintain upright positioning, reverse lung compression and sustain lung expansion accord with a logical physiologic rationale. Read More
FEBS Lett 2018 Dec 6. Epub 2018 Dec 6.
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan.
TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein, whose loss-of-function mutation causes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Recent studies demonstrated that TDP-43 binds to the 3' UTR of target mRNAs to promote mRNA instability. Here, we show that TDP-43 recruits Caf1 deadenylase to mRNA targets and accelerates their deadenylation. Read More
Psychol Med 2018 Dec 6:1-12. Epub 2018 Dec 6.
Department of Psychiatry and Behavioral Sciences,Baltimore, MD,USA.
Background: Though meta-analyses of neuropsychological and social cognitive deficits in behavioral variant frontotemporal dementia (bvFTD) have been conducted, no study has comprehensively characterized and compared the neuropsychological, social cognitive, and olfactory profiles in the behavioral and language variants of FTD.
Methods: Our search yielded 470 publications meeting inclusion criteria representing 11 782 FTD patients and 19 451 controls. For each domain, we calculated Hedges' g effect sizes, which represent the mean difference between the patient and control group divided by the pooled standard deviation. Read More
Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.
Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, No.5, Fuxing St., Guishan Township, Taoyuan County 333, Taiwan.
Differences in the incidence of spontaneous intracerebral hemorrhage (ICH) between ethnicities exist, with an estimated 42% of the variance explained by ethnicity itself. Caucasians have a higher proportion of lobar ICH (LICH, 15.4% of all ICH) than do Asians (3. Read More
Thorac Cancer 2018 Dec 2. Epub 2018 Dec 2.
Division of Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea.
Background: Pulmonary emphysema is a major component of chronic obstructive pulmonary disease and lung cancer. However the prognostic significance of quantitative emphysema severity in patients with lung cancer is unclear. We analyzed whether numerical emphysema value is a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer. Read More
J Neurol 2018 Dec 1. Epub 2018 Dec 1.
Neurologische Klinik und Poliklinik, Ludwig Maximilians Universität München, Munich, Germany.
The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP). Read More
J Thorac Dis 2018 Oct;10(10):5850-5859
Division of Hematology, Oncology, Blood & Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) sub-lobar resection (SL-R), is controversial. Read More
Mol Neurodegener 2018 Dec 4;13(1):63. Epub 2018 Dec 4.
Department of Neurology, The McGovern Medical School of UT Health, Houston, TX, USA.
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two fatal neurodegenerative disorders with considerable clinical, pathological and genetic overlap. Both disorders are characterized by the accumulation of pathological protein aggregates that contain a number of proteins, most notably TAR DNA binding protein 43 kDa (TDP-43). Surprisingly, recent clinical studies suggest that dyslipidemia, high body mass index, and type 2 diabetes mellitus are associated with better clinical outcomes in ALS. Read More
Folia Neuropathol 2018 ;56(2):81-87
Introduction: The prevalence of dementia is increasing in our aging population. Because of the complexity of disease pathology, dementia classifications remain controversial. The present post-mortem study investigates whether there are age differences between dementia brains with a single pure neurodegenerative or cerebrovascular disease and those with mixed pathological features. Read More
Mod Rheumatol 2018 Nov 30:1-24. Epub 2018 Nov 30.
c Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine , Fukuoka University , Fukuoka , Japan.
The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter. Read More
BMJ Paediatr Open 2018 27;2(1):e000367. Epub 2018 Oct 27.
Institute of Applied Clinical Science, Keele University, Keele, UK.
Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocols used to obtain scans.
Design Setting And Participants: An electronic questionnaire was developed to assess clinicians views on chest CT in children with CF. Read More
PLoS One 2018 29;13(11):e0207708. Epub 2018 Nov 29.
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Background: We hypothesized that slow crystalloid resuscitation would result in less blood loss and a smaller hemoglobin decrease compared to a rapid resuscitation during uncontrolled hemorrhage.
Methods: Anesthetized, splenectomized domestic swine underwent hepatic lobar hemitransection. Lactated Ringers was given at 150 or 20 mL/min IV (rapid vs. Read More
Mymensingh Med J 2018 Oct;27(4):702-709
Dr Afroza Begom, Indoor Medical Officer, Department of Pediatrics, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.
Pneumonia is the leading cause of morbidity and mortality in children less than 5 years of age in developing countries like Bangladesh. Although WHO guideline classified severe pneumonia by symptoms and signs of the patients, radiological and laboratory investigations were not studied well. There was increasing number of cases of bronchiolitis which meet the criteria of WHO classified severe pneumonia are reported. Read More
Rev Neurol 2018 Dec;67(11):436-440
Complejo Hospitalario Universitario de Vigo, 36200 Vigo, Espana.
Introduction: The behavioural variant of frontotemporal dementia is characterised by progressive social, cognitive and personality deterioration associated with several molecular pathologies of frontotemporal lobar dementia (FTLD): FTLD-tau, FTLD-TDP and FTLD-FUS. Its diagnosis requires pathological studies.
Case Report: A 61-year-old male, with a three-year progressive history of behavioural disorder, apathy, poor language skills, perseveration, lack of empathy, bulimia and executive dysfunction. Read More
Dement Geriatr Cogn Disord 2018 Nov 27;46(5-6):310-321. Epub 2018 Nov 27.
Clinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, CHU de Québec, Faculté de médecine, Université Laval, Québec, Québec,
Introduction: Early recognition of atypical dementia remains challenging partly because of lack of cognitive screening instruments precisely tailored for this purpose.
Methods: We assessed the validity and reliability of the Dépistage Cognitif de Québec (DCQ; www.dcqtest. Read More
World Neurosurg 2018 Nov 24. Epub 2018 Nov 24.
Neurosurgical Clinic, AOUP "Paolo Giaccone", PostGraduate Residency Program in Neurologic Surgery,Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, University ofPalermo, 90127 Palermo, Italy.
Background: While the incidence of intracerebral haemorrhage (ICH) appear to be increasing over the year, its prognosis still remains dismal . Although no consensus about the management of ICH has be found, minimal invasive surgery should limit - when not avoid - the intra operative parenchymal damage. At this regard, we present a novel modified "home made" approach, aimed to shorten the operative time and minimize the corticectomy and brain manipulation, with our clinical series. Read More
DNA Cell Biol 2018 Nov 27. Epub 2018 Nov 27.
Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town, South Africa .
Mitochondria are critical for cellular survival, and for their proper functioning, translocation of ∼1500 proteins across the mitochondrial membranes is required. The translocase of the outer (TOMM) and inner mitochondrial membrane (TIMM) complexes are major components of this translocation machinery. Through specific processes, preproteins and other molecules are imported, translocated, and directed to specific mitochondrial compartments for their function. Read More
ERJ Open Res 2018 Oct 23;4(4). Epub 2018 Nov 23.
Dept of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
There are few studies looking at the pulmonary circulation in subjects with bronchiectasis. We aimed to evaluate the intraparenchymal pulmonary vascular structure, using noncontrast chest computed tomography (CT), and its clinical implications in smokers with radiographic bronchiectasis. Visual bronchiectasis scoring and quantitative assessment of the intraparenchymal pulmonary vasculature were performed on CT scans from 486 smokers. Read More
Acta Neuropathol 2018 Nov 26. Epub 2018 Nov 26.
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
The genetic underpinnings of the most common adult-onset neurodegenerative disorders (AOND) are complex in majority of the cases. In some families, however, the disease can be inherited in a Mendelian fashion as an autosomal-dominant trait. Next to that, patients carrying mutations in the same disease genes have been reported despite a negative family history. Read More
Neurosurgery 2018 Nov 23. Epub 2018 Nov 23.
Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri.
Background: Laser ablation (LA) is used as an upfront treatment in patients with deep seated newly diagnosed Glioblastoma (nGBM).
Objective: To evaluate the outcomes of LA in patients with nGBM and compare them with a matched biopsy-only cohort.
Methods: Twenty-four nGBM patients underwent upfront LA at Cleveland clinic, Washington University in St. Read More
J Mol Neurosci 2018 Nov 22. Epub 2018 Nov 22.
Central Clinical School and Brain and Mind Centre, Faculty of Medicine and Health Sciences, The University of Sydney, 94 Mallet Street, Camperdown, NSW, Australia.
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the two common forms of dementia. FTD syndromes are characterized by lobar atrophy (frontotemporal lobar degeneration or FTLD) and the presence of either cellular TDP43 (FTLD-TDP), tau (FTLD-tau), or FUS aggregates, while extracellular β-amyloid plaques and hyperphosphorylated tau tangles develop in AD. Oxidative stress can induce these pathological modifications in disease models, and is thought to play a role in these syndromes. Read More
Turk Pediatri Ars 2018 Sep 1;53(3):189-192. Epub 2018 Sep 1.
Clinic of Pediatrics, Ankara Training and Research Hospital, Ankara, Turkey.
In infants, tuberculosis usually progresses as hilar lymphadenopathy and parenchyma changes in lungs; associating cavitary lesions are rare. A six-month-old infant was admitted to our hospital with fever. Physical examination revealed decreased breathe sounds in the right lung. Read More
J Int Neuropsychol Soc 2018 Nov 21:1-11. Epub 2018 Nov 21.
1Columbia University,Cognitive Neuroscience Division of the Taub Institute,G.H. Sergievsky Center,Department of Neurology,New York, New York.
Objectives: The cognitive indicators of preclinical behavioral variant Frontotemporal Dementia (bvFTD) have not been identified. To investigate these indicators, we compared cross-sectional performance on a range of cognitive measures in 12 carriers of pathogenic MAPT mutations not meeting diagnostic criteria for bvFTD (i.e. Read More
Br J Neurosurg 2018 Nov 19:1-3. Epub 2018 Nov 19.
a Department of Neurosurgery , The First Affiliated Hospital of Zhengzhou University , ZhengZhou , HeNan Province , PR China.
Germinoma is rare in peripheral lobar locations in the brain, with only 10 cases of primary frontal lobe germinoma having been reported in the previous literature. Epilepsy is a rare manifestation of germinomas. We describe an unusual case of a primary frontal germinoma in a 21-year-old man who presented with epilepsy. Read More
J Thorac Dis 2018 Oct;10(Suppl 27):S3326-S3334
Dipartimento Cardio-Toraco-Vascolare, University of Milan Bicocca, Respiratory Unit, San Gerardo Hospital, ASST di Monza, Monza, Italy.
Lung volume reduction (LVR) procedures for emphysematous patients were firstly introduced in the second half of the twentieth century. Over time, from the first invasive surgical procedures, new less invasive techniques have been conceived. In regards to the surgical approach, the adoption of VATS and the execution, in selected centers, of a non-resectional approach, with folding of less functional lung tissue, reduced mortality and adverse events risks. Read More
J Thorac Dis 2018 Oct;10(Suppl 27):S3315-S3325
Thoracic Surgery Unit, Università La Sapienza, Sant'Andrea Hospital, Rome, Italy.
Background: Despite bronchoscopic lung volume reduction (BLVR) with valves is a minimally invasive treatment for emphysema, it can associate with some complications. We aimed at evaluating the rate and type of complications related to valve treatment and their impact on clinical outcomes.
Methods: It is a retrospective multicenter study including all consecutive patients with severe heterogeneous emphysema undergoing BLVR with endobronchial valve treatment and developed any complications related to this procedure. Read More
Surg Oncol 2018 Dec 7;27(4):630-634. Epub 2018 Aug 7.
Facultad de Medicina de la Universidad de Granada, Hospital Universitario Clinico, Campus de la Salud, Granada, Spain.
Introduction: Mortality following surgery for lung cancer increases at 90 days. The objective of this study was to determine the rate, factors, time to death, hospital stay until discharge, time to death after discharge and causes of mortality at 90 days following surgery for lung cancer.
Methods: A prospective follow-up study was performed in a cohort of 378 patients who underwent surgery for lung cancer between January 2012 and December 2016. Read More
Muscle Nerve 2018 Nov 17. Epub 2018 Nov 17.
Neurology Department, Centro Hospitalar e Universitário de Coimbra, Portugal.
Introduction: Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are considered part of the same pathological spectrum. There is an increased risk of ALS in patients who have had melanoma. The risk of FTLD in melanoma (or cancer) patients is unknown. Read More
Lancet Respir Med 2018 Nov 12. Epub 2018 Nov 12.
State University of New York Upstate Medical University, Syracuse, NY, USA.
Background: Increased detection of small-sized, peripheral, non-small-cell lung cancer has renewed interest in sublobar resection instead of lobectomy, the traditional standard of care for early-stage lung cancer. We aimed to assess morbidity and mortality associated with lobar and sublobar resection for early-stage lung cancer.
Methods: CALGB/Alliance 140503 is a multicentre, international, non-inferiority, phase 3 trial in patients with peripheral non-small-cell lung cancer clinically staged as T1aN0. Read More
Emerg Radiol 2018 Nov 13. Epub 2018 Nov 13.
Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Purpose: To compare the causes of indeterminate CT pulmonary angiograms using standard mode and high-pitch mode, and determine at what level of the pulmonary arterial tree studies were non-diagnostic.
Methods: IRB approval was obtained. A retrospective review of patients at our institution who underwent a CT pulmonary angiogram, between November 1, 2015 and February 10, 2016 was performed. Read More
Dement Geriatr Cogn Disord 2018 Nov 13;46(5-6):285-297. Epub 2018 Nov 13.
Centre for Neuroscience of Speech, The University of Melbourne, Melbourne, Victoria,
Background: Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common and significant outcome of FTLD. Disturbances during mealtimes can arise from dysphagia or may occur secondary to behavioral changes such as rapid eating, mealtime rigidity, and altered diet preferences. Read More
J Thorac Dis 2018 Sep;10(9):5576-5583
Department of Surgery, Zuyderland Medical Center, Heerlen, The Netherlands.
Bronchial rupture by blunt chest trauma is rare. We present a case of bronchial injury after blunt chest trauma that was repaired surgically by primary reconstruction. We performed a review of literature to verify if primary reconstruction is suitable for the treatment of adult patients with blunt bronchial injury. Read More
J Korean Med Sci 2018 Nov 19;33(46):e289. Epub 2018 Oct 19.
Department of Neurology, Seoul National University Bundang Hospital, Seoul National University Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated.
Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. Read More
J Stroke Cerebrovasc Dis 2018 Nov 8. Epub 2018 Nov 8.
Department of Neurosurgery, Maebashi Red Cross Hospital, Maebashi, Gunma, Japan. Electronic address:
Background: Patients with intracerebral hemorrhage taking anticoagulants are increasingly common in Japan due to the aging population. The clinical benefit of restarting anticoagulants is established, but the optimal timing of resumption is controversial. Risk factors for hemorrhagic and cardioembolic events in the acute phase are also unknown. Read More
J Heart Lung Transplant 2018 Sep 25. Epub 2018 Sep 25.
Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address:
Background: We have developed a novel method for native upper lobe-sparing living-donor lobar lung transplantation (LDLLT) to overcome a small-for-size graft in standard LDLLT with acceptable results. We hypothesized that grafts implanted with this procedure might work more efficiently than those in standard lobe transplantation.
Methods: Bilateral LDLLT was performed in 31 patients with a functional graft matching of less than 60% at our institution between August 2008 and December 2015. Read More
Front Vet Sci 2018 22;5:260. Epub 2018 Oct 22.
Neurology Department, Clinic of Small Animal Surgery, Vetsuisse-Faculty Zurich, Zurich, Switzerland.
Corpus callosum abnormalities (CCA) rarely occur in dogs and are related to hypo/adypsic hypernatremia and seizures. Hypoplasia and dysplasia of the corpus callosum (CC) with concomitant lobar holoprosencephaly is the most common variant. It is currently uncertain using conventional MRI if canine CCA reflects the failure of commissural fibers to develop or the failure of the commissural fibers to cross hemispheres. Read More
J Biomed Sci 2018 Nov 8;25(1):76. Epub 2018 Nov 8.
Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology/Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei, 115, Taiwan.
Background: The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neurons of adult mouse models for amyotrophic lateral sclerosis (ALS), yet the molecular function of Znf179 in neurodegeneration has never been previously described. Znf179 contains the classical C3HC4 RING finger domain, and numerous proteins containing C3HC4 RING finger domain act as E3 ubiquitin ligases. Read More
Ann Med Surg (Lond) 2018 Dec 17;36:54-57. Epub 2018 Oct 17.
Tecnologico de Monterrey, Hospital San Jose, Servicio de Patologia, Mexico.
Introduction: Panniculits presents as an inflammation of the subcutaneous adipose tissue of the skin. In breast, panniculitis is very rare and is usually a manifestation of underlying inflammatory conditions. The typical presentation is palpable tender nodules, which in cases of breast panniculitis, triggers an extensive work up to exclude a malignancy. Read More
Alzheimers Res Ther 2018 Nov 6;10(1):114. Epub 2018 Nov 6.
Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore, Singapore.
Background: Low haemoglobin is highly prevalent among the elderly and has been associated with dementia. However, the mechanisms underlying this association with cognitive dysfunction, either through cerebrovascular disease or neurodegeneration, remain poorly understood. We aimed to examine the association of decreased haemoglobin levels with markers of cerebral small vessel disease (CSVD), neurodegeneration and cognitive impairment in an elderly Asian population. Read More
Mol Cell Neurosci 2018 Nov 3. Epub 2018 Nov 3.
Department of Neurology, University of Ulm, Ulm, Germany. Electronic address:
The discovery that aggregated transactive response DNA-binding protein 43 kDa (TDP-43) is the major component of pathological ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) caused seminal progress in the unveiling of the genetic bases and molecular characteristics of these now so-called TDP-43 proteinopathies. Substantial increase in the knowledge of clinic-pathological coherencies, especially for FTLD variants, could be made in the last decade, but also revealed a considerable complexity of TDP-43 pathology and often a poor correlation of clinical and molecular disease characteristics. To date, an underlying TDP-43 pathology can be predicted only for patients with mutations in the genes C9orf72 and GRN, but is dependent on neuropathological verification in patients without family history, which represent the majority of cases. Read More
Eur J Radiol 2018 Nov 9;108:254-260. Epub 2018 Oct 9.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, Room 143, Baltimore, MD, 21287, USA. Electronic address:
Objectives: To correlate total and lobar liver and spleen volume with disease severity in primary sclerosing cholangitis (PSC) as determined by Mayo risk score.
Methods: This HIPAA-compliant single center retrospective study included 147 PSC patients with available imaging studies (MRCP/CT) and laboratory data between January 2003 and January 2018. Total and lobar (right, left and caudate) liver volume and spleen volume were measured. Read More
Psychogeriatrics 2018 Nov 4. Epub 2018 Nov 4.
Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Adult-onset leucoencephalopathy with axonal spheroids and pigmented glia (ALSP), also known as hereditary diffuse leucoencephalopathy with spheroids (HDLS), is a progressive neurocognitive disorder that predominantly affects the cerebral white matter, mainly the frontal subcortical areas and the corpus callosum. Patients with ALSP are clinically characterized by a gradual onset of cognitive and behavioural dysfunction and personality changes, followed by motor impairments such as gait disturbance and bradykinesia. Given the disease-related degenerative changes of the frontal white matter, it is no wonder that patients with ALSP present with behavioural symptoms and non-fluent aphasia, which are found in patients with frontotemporal lobar degeneration. Read More
Brain Struct Funct 2018 Nov 2. Epub 2018 Nov 2.
FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Lemminkäisenkatu 3, 2nd floor, 20520, Turku, Finland.
Information on normal brain structure and development facilitates the recognition of abnormal developmental trajectories and thus needs to be studied in more detail. We imaged 68 healthy infants aged 2-5 weeks with high-resolution structural MRI (magnetic resonance imaging) and investigated hemispheric asymmetry as well as the associations of various total and lobar brain volumes with infant age and sex. We found similar hemispheric asymmetry in both sexes, seen as larger volumes of the right temporal lobe, and of the left parietal and occipital lobes. Read More
Respir Care 2018 Nov;63(11):1399-1406
Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China.
Background: Airway remodeling is a characteristic structural change that occurs extensively in the airways of patients with asthma. The change can be evaluated by measuring airway dimensions by using high-resolution computed tomography. This study aimed to explore the variation trends of airway dimensions from the second- to sixth-generation bronchi in subjects with asthma. Read More