Search Our Scientific Publications & Authors

Dig Dis Sci 2022 May 17. Epub 2022 May 17.

Translational and Clinical Research Institute, Newcastle University and Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.

Background: Data show that patients with autoimmune hepatitis have significantly reduced quality-of-life and that corticosteroids carry marked side effects.

Aims: This study explored patients' experiences of autoimmune hepatitis and its treatments; key aspects for developing safe and effective new approaches to therapy.

Methods: An anonymised, internet-based survey collected data including patient demographics, treatments, side-effects, impact on day-to-day life, sources of support and attitudes towards autoimmune hepatitis between December 2019-January 2020. Read More

Eur Radiol 2022 May 17. Epub 2022 May 17.

Department of Radiology, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, China.

Objectives: To determine the performance of diagnostic algorithm of adding hepatobiliary phase (HBP) images in Gd-EOB-DTPA-enhanced MRI for the detection of hepatocellular carcinoma (HCC) measuring up to 3 cm in patients with chronic liver disease.

Methods: We searched multiple databases from inception to April 10, 2020, to identify studies on using Gd-EOB-DTPA-enhanced MRI for the diagnostic accuracy of HCC (≤ 3 cm) in patients with chronic liver disease. The diagnostic algorithm of Gd-EOB-DTPA-enhanced MRI with HBP for HCC was defined as a nodule showing hyperintensity during arterial phase and hypointensity during the portal venous, delayed, or hepatobiliary phases. Read More

Toxicol Ind Health 2022 May 17:7482337221098319. Epub 2022 May 17.

The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education Department of Toxicology, School of Public Health, 74628Guizhou Medical University, Guiyang, China.

Arsenic is widely present in nature and is a class I carcinogen confirmed by the World Health Organization and the International Agency for Research on Cancer. The liver is responsible for biotransformation in the body and is one of the major organs where arsenic accumulates in the body, but the mechanisms of arsenic-induced abnormal DNA damage repair pathways in the liver are still unclear. Recent studies have revealed that epigenetic mechanisms play an important role in arsenic-induced lesions. Read More

Transpl Infect Dis 2022 May 17. Epub 2022 May 17.

Abu Ali Sina Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Liver transplantation (LT) is considered the only treatment for patients with end-stage liver disease and, despite its incredible impacts on the patients' health status, places them in an immunocompromised state in which opportunistic infection would find a way to present. Latent Tuberculosis Infection (LTBI) is the most common form of TB and can be diagnosed through Tuberculin Skin Test (TST) or Interferon-Gamma Release Assays (IGRA). LT recipients are at significant risk of TB activation. Read More

Pol Arch Intern Med 2022 May 17. Epub 2022 May 17.

Introduction: Clinically overt depression is associated with an increased risk for insulin resistance. Data regarding the impact of subclinical depressive symptoms on the risk of diabetes is limited.

Objectives: The study aimed to assess the relationship of subclinical depressive symptoms both with body fat distribution and with diabetes risk in women. Read More

Gigascience 2022 May;11

Faculty of Medicine, Ain Shams University, 38 Abbassia, Next to the Al-Nour Mosque, Cairo, Postal code: 1181, Egypt.

Background: Deep learning enables accurate high-resolution mapping of cells and tissue structures that can serve as the foundation of interpretable machine-learning models for computational pathology. However, generating adequate labels for these structures is a critical barrier, given the time and effort required from pathologists.

Results: This article describes a novel collaborative framework for engaging crowds of medical students and pathologists to produce quality labels for cell nuclei. Read More

Radiology 2022 May 17:212302. Epub 2022 May 17.

Department of Radiology, Pardis Noor Medical Imaging Center, Tehran, Iran.

Radiology 2022 May 17:212154. Epub 2022 May 17.

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu 610041, People's Republic of China.

Microbiol Spectr 2022 May 17:e0061922. Epub 2022 May 17.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

Typhoid fever is caused primarily by the enteric microbe Salmonella enterica serovar Typhi and remains a major global health problem with approximately 14 million new infections and 136,000 fatalities annually. While there are antibiotic options available to treat the disease, the global increase in multidrug-resistant strains necessitates alternative therapeutic options. Host-targeted therapeutics present a promising anti-infective strategy against intracellular bacterial pathogens. Read More

Bioengineered 2022 May;13(5):12237-12247

The Third Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.

Long non-coding RNAs are essential to hepatocellular carcinoma (HCC) development, progression, and incidence of drug resistance. However, the biological significance of long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) remains poorly characterized. In this study, we observed noticeable increased levels of MKLN1-AS in HCC tissues. Read More

Transplantation 2022 May 17. Epub 2022 May 17.

Division of Transplant Surgery, Department of Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO.

Background: Pediatric living donor liver transplantation (LDLT) remains infrequently performed in the United States and localized to a few centers. This study aimed to compare pediatric waiting list and posttransplant outcomes by LDLT center volume.

Methods: The Scientific Registry of Transplant Recipients/Organ Procurement and Transplantation Network database was retrospectively reviewed for all pediatric (age <18 y) liver transplant candidates listed between January 1, 2009, and December 31, 2019. Read More

Transplantation 2022 May 17. Epub 2022 May 17.

Department of Surgery, University of California, San Francisco, CA.

Bioengineered 2022 May;13(5):12548-12557

Department of Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

This study aimed to develop a prediction model for the prognosis of patients with Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). 122 patients were divided into survival group and death group according to 90-day prognosis after diagnosis. Risk factors affecting the prognosis were identified by the logistic regression analysis and then were used to establish an FT3-related prediction model. Read More

Genetics 2022 May 17. Epub 2022 May 17.

Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, School of Chemistry and Molecular Engineering, School of Pharmaceutical Sciences, Peking University, Beijing 100871, China; Chinese Institute for Brain Research, Beijing; Capital Medical University; Changping Laboratory, Beijing, China.

Liver Kinase B1 (LKB1) is known as a master kinase for 14 kinases related to the adenosine monophosphate (AMP)-activated protein kinase (AMPK). Two of them salt inducible kinase 3 (SIK3) and AMPKα have previously been implicated in sleep regulation. We generated loss-of-function (LOF) mutants for Lkb1 in both Drosophila and mice. Read More

Mol Syst Biol 2022 May;18(5):e10947

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Deeper understanding of liver pathophysiology would benefit from a comprehensive quantitative proteome resource at cell type resolution to predict outcome and design therapy. Here, we quantify more than 150,000 sequence-unique peptides aggregated into 10,000 proteins across total liver, the major liver cell types, time course of primary cell cultures, and liver disease states. Bioinformatic analysis reveals that half of hepatocyte protein mass is comprised of enzymes and 23% of mitochondrial proteins, twice the proportion of other liver cell types. Read More

Eur J Gen Pract 2022 Dec;28(1):102-108

The Institute of Gastroenterology and Hepatology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Hepatitis C Virus (HCV) is a common cause of chronic liver disease and its ensuing complications. In the last years, there has been a revolution of the treatment for patients with HCV regarding efficacy, simplicity, safety and duration of treatment. The role of the family physician is vital in all steps of care: screening, diagnosis, linkage to treatment, treatment and follow-up. Read More

Curr Mol Med 2022 May 9. Epub 2022 May 9.

Department of Mesenchymal Stem Cells, Academic Center for Education, Culture and Research (ACECR), Qom Branch, Qom, Iran.

Long noncoding RNAs (lncRNAs) are prominent as crucial regulators of tumor establishment and are repeatedly dysregulated in multiple cancers. Therefore, lncRNAs have been identified to play an essential function in carcinogenesis and progression of cancer at genetic and epigenetic levels. FENDRR (fetal-lethal noncoding developmental regulatory RNA) as an LncRNA is a hallmark of various malignancies. Read More

ANZ J Surg 2022 May 17. Epub 2022 May 17.

Department of Surgery, North Shore Hospital, Auckland, New Zealand.

Background: Choledochal cysts should be treated with complete surgical resection, or, rarely liver transplantation. Treated patients can remain at risk of developing metachronous cholangiocarcinomas and lifelong follow up is indicated. However, there is no agreement on what constitutes an acceptable follow up strategy. Read More

Compr Physiol 2022 Mar 29;12(2):3167-3192. Epub 2022 Mar 29.

Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

The increased production of derivatives of molecular oxygen and nitrogen in the form of reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular damage called oxidative stress. Under normal physiological conditions, the ROS generation is tightly regulated in different cells and cellular compartments. Any disturbance in the balance between the cellular generation of ROS and antioxidant balance leads to oxidative stress. Read More

Gan To Kagaku Ryoho 2022 May;49(5):589-592

Dept. of Surgery, Tsuyama Chuo Hospital.

Oral uracil and tegafur plus Leucovorin(UFT/LV)therapy is one of the standard adjuvant chemotherapies for colorectal cancer, and is widely used without any serious adverse events. Herein, we describe a case of UFT/LV-induced acute liver failure in a 75-year-old woman who underwent laparoscopic sigmoidectomy for sigmoid colon cancer. She was diagnosed with advanced colon cancer and lymph node metastasis by postoperative histopathological analysis, and adjuvant chemotherapy was initiated. Read More

Br J Surg 2022 May 17. Epub 2022 May 17.

Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Manchester, UK.

Elife 2022 May 17;11. Epub 2022 May 17.

Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Medical Universitaire (CMU), University of Geneva, Geneva, Switzerland.

Thermal adaptation is an extensively used intervention for enhancing or suppressing thermogenic and mitochondrial activity in adipose tissues. As such, it has been suggested as a potential lifestyle intervention for body weight maintenance. While the metabolic consequences of thermal acclimation are not limited to the adipose tissues, the impact on the rest of the tissues in context of their gene expression profile remains unclear. Read More

Curr Mol Med 2022 May 16. Epub 2022 May 16.

Key Laboratory of Antibody Technique, Huadong Medical Institute of Biotechniques, Nanjing 210002, China.

Background And Objective: Acetaminophen (APAP) is a widely used antipyretic and analgesic. If taken in excess, it can cause severe drug-induced acute liver injury The purpose of this study was to investigate the effects of anti-TLR4 IgG2 in APAP-induced liver injury and its underlying mechanisms.

Methods: We injected APAP into the abdominal cavity of mice to establish a liver injury model. Read More

Curr Med Imaging 2022 May 16. Epub 2022 May 16.

Kırşehir Ahi Evran University Medical Faculty,Department of Radiology, Kırşehir, Turkey.

Objectives: Non-alcoholic fatty liver disease [NAFLD], may affect many organs and systems, especially the kidney, as well as the liver. While NAFLD's renal impacts can be evaluated via the estimated glomerular filtration rate [eGFR], its effects on renal hemodynamic changes can be monitored with renal resistive index [RRI]. Our aim in this study is to evaluate RRI and eGFR in NAFLD patients. Read More

Curr Pharm Des 2022 May 16. Epub 2022 May 16.

Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.

Background: As a member of long non-coding RNAs (lncRNAs), maternally expressed gene 8 (MEG8) has been found involving in the progression of a variety of cancers and playing a regulatory role. Therefore, MEG8 may turn into a new therapeutic target for cancer in the future. The purpose of this review is to illustrate the molecular mechanism and physiological function of MEG8 in various cancers. Read More

Comb Chem High Throughput Screen 2022 May 16. Epub 2022 May 16.

College of Integrative Medicine,Hebei University of Chinese Medicine, Shijiazhuang, China.

Background: Long non-coding RNAs (lncRNAs) containing microRNA (miRNA) response elements (MREs) can be used as competitive endogenous RNAs (ceRNAs) to regulate gene expression.

Objective: The purpose of this study was to investigate the expression profile and role of mRNAs and lncRNAs in unilateral ureteral obstruction (UUO) model rats and to explore any associated competing endogenous (ceRNA) network.

Methods: Using the UUO model, the obstructed kidney was collected on the 15th day after surgery. Read More

EMBO Rep 2022 May 17:e53791. Epub 2022 May 17.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.

Interleukin-38 (IL-38) is strongly associated with chronic inflammatory diseases; however, its role in tumorigenesis is poorly understood. We demonstrated that expression of IL-38, which exhibits high expression in the skin, is downregulated in human cutaneous squamous cell carcinoma and 7,12-dimethylbenzanthracene/12-O-tetradecanoyl phorbol-13-acetate-induced mouse skin tumorigenesis. IL-38 keratinocyte-specific knockout mice displayed suppressed skin tumor formation and malignant progression. Read More

ANZ J Surg 2022 May 16. Epub 2022 May 16.

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Hepatic epithelioid angiomyolipomas (HEAMLs) are rare and usually arise in case reports, and thus, we aimed to study the clinicopathological features, treatment and prognosis of these lesions.

Methods: We identified patients from institutional database with HEAMLs and retrospectively collected clinical data.

Results: Of 12 patients, 10 were females, and the median age was 49 years. Read More

J Surg Oncol 2022 May 16. Epub 2022 May 16.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: As minimally invasive surgery (MIS) approaches to biliary tract cancers become more commonplace, understanding the adequacy of their oncologic performance is key.

Methods: The National Cancer Database 2010-2016 was queried for patients who underwent hepatectomy for intrahepatic cholangiocarcinoma (IHC) and T1b or more advanced gallbladder cancer (GBC). Patients were grouped by approach: open (OA), laparoscopic (LA), and robotic (RA). Read More

Clin Infect Pract 2022 May 12:100145. Epub 2022 May 12.

Department of Critical Care Medicine, Kuwait Bangladesh Maitry Govt. Hospital, Dhaka, Bangladesh.

Background: The novel coronavirus disease, commonly called COVID-19, has already killed millions of lives. Our study aimed to identify a safe and right drug for the management of such globally threatened COVID-19.

Methods: This preliminary double-blinded randomized controlled trial was done among 57 hospitalized COVID-19 patients in the early stage of their illness. Read More