24,748 results match your criteria Liver Trauma


Abdominal trauma: experience of 4961 cases in Western Mexico.

Cir Cir 2019 ;87(2):183-189

Servicio de Cirugía Medicina Legal, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.

Introduction: Trauma is a leading cause of morbimortality in the world. Intraabdominal compartment is the third most affected anatomical region and bleeding from this origin is difficult to identify, therefore the importance to predict possible lesions to the abdominal cavity.

Objective: To describe and analyze the sociodemographic profile and injuries found in patients with abdominal trauma in a western hospital in Mexico. Read More

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http://dx.doi.org/10.24875/CIRU.18000509DOI Listing
January 2019

Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering.

Stem Cells Int 2019 13;2019:9671206. Epub 2019 Jan 13.

Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma War Injuries, PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.

The inflammatory response to chronic injury affects tissue regeneration and has become an important factor influencing the prognosis of patients. In previous stem cell treatments, it was revealed that stem cells not only have the ability for direct differentiation or regeneration in chronic tissue damage but also have a regulatory effect on the immune microenvironment. Stem cells can regulate the immune microenvironment during tissue repair and provide a good "soil" for tissue regeneration. Read More

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http://dx.doi.org/10.1155/2019/9671206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350611PMC
January 2019

Sepsis: mechanisms of bacterial injury to the patient.

Authors:
Hayk Minasyan

Scand J Trauma Resusc Emerg Med 2019 Feb 14;27(1):19. Epub 2019 Feb 14.

, Yerevan, Armenia.

In bacteremia the majority of bacterial species are killed by oxidation on the surface of erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing bacteria overcome this mechanism of human innate immunity by versatile respiration, production of antioxidant enzymes, hemolysins, exo- and endotoxins, exopolymers and other factors that suppress host defense and provide bacterial survival. Entering the bloodstream in different forms (planktonic, encapsulated, L-form, biofilm fragments), they cause different types of sepsis (fulminant, acute, subacute, chronic, etc. Read More

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http://dx.doi.org/10.1186/s13049-019-0596-4DOI Listing
February 2019

Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

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http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing

Safety and feasibility of minocycline in treatment of acute traumatic brain injury.

Brain Inj 2019 Feb 12:1-11. Epub 2019 Feb 12.

a Department of Physical Medicine and Rehabilitation-Oakwood, School of Medicine , Wayne State University , Taylor , MI , USA.

Background: Minocycline is a pleomorphic neuroprotective agent well studied in animal models of traumatic brain injury (TBI) and brain ischemia.

Methods: To test the hypothesis that administration of minocycline in moderate to severe TBI (Glasgow Coma Score 3-12). Fifteen patients were enrolled in a two-dose escalation study of minocycline to evaluate the safety of twice the recommended antibiotic dosage; tier 1 n = 7 at a loading dose of 800 mg followed by 200 mg twice a day (BID) for 7 days; tier 2 n = 8 at a loading dose of 800 mg followed by 400 mg BID for 7 days. Read More

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http://dx.doi.org/10.1080/02699052.2019.1566968DOI Listing
February 2019

Post-Stress Fructose and Glucose Ingestion Exhibit Dissociable Behavioral and Physiological Effects.

Nutrients 2019 Feb 9;11(2). Epub 2019 Feb 9.

Department of Psychology, University of California, Los Angeles, CA 90095, USA.

An acute traumatic event can lead to lifelong changes in stress susceptibility and result in psychiatric disease such as Post-Traumatic Stress Disorder (PTSD). We have previously shown that access to a concentrated glucose solution for 24 hours beginning immediately after trauma decreased stress-related pathology in the learned helplessness model of PTSD and comorbid major depression. The current study sought to investigate the peripheral physiological effects of post-stress glucose consumption. Read More

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http://dx.doi.org/10.3390/nu11020361DOI Listing
February 2019

Gastrointestinal stromal tumor leading to acute abdomen and hypovolemic shock in a trauma patient.

Ulus Travma Acil Cerrahi Derg 2019 Jan;25(1):83-85

Department of General Surgery, İstanbul Medicine Hospital, İstanbul-Turkey.

Gastrointestinal stromal tumors (GISTs) are among the rare tumors of gastrointestinal (GI) tract. GISTs occur respectively in the stomach, small intestines, colon and rectum, omentum and mesentery, esophagus, retroperitoneal space, and abdominal cavity. However, they may occur anywhere along the GI tract. Read More

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http://www.tjtes.org/eng/jvi.aspx?pdir=travma&plng=eng&a
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http://dx.doi.org/10.5505/tjtes.2018.35005DOI Listing
January 2019
3 Reads

Injectable chitosan-nano bioglass composite hemostatic hydrogel for effective bleeding control.

Int J Biol Macromol 2019 Feb 6. Epub 2019 Feb 6.

Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi 682041, India. Electronic address:

Effective bleeding control is a major concern in trauma and major surgeries. Chitosan (Ch) as hemostatic agent has been widely used and when applied at the site of injury it acts by aggregating blood cells and forming a plug. Our prime interest is to enhance the blood clotting potential of Ch hydrogel. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.220DOI Listing
February 2019

Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties.

Oxid Med Cell Longev 2019 6;2019:9529676. Epub 2019 Jan 6.

School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.

Extensive exposure to UVB (280-320 nm) is the major risk responsible for various skin injuries. Numerous reports have shown that natural products could demonstrate photochemopreventive efficacy against UVB damage. We investigated the preventive effects and associated molecular mechanisms of red raspberry extract upon UVB-caused damage in human epidermal keratinocytes and a nude mouse model. Read More

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http://dx.doi.org/10.1155/2019/9529676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339709PMC
January 2019
1 Read

Direct oral anticoagulant successfully used to treat an adult nephrotic patient complicated with portal vein thrombosis.

CEN Case Rep 2019 Feb 5. Epub 2019 Feb 5.

Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Tokushima, Japan.

Thromboembolism is a major complication of nephrotic syndrome, with the renal vein being the most frequent site. However, the incidence of portal vein thrombosis (PVT) in patients with nephrotic syndrome is rare. We report a case of a relapsed steroid-dependent minimal change disease with incidental PVT. Read More

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http://dx.doi.org/10.1007/s13730-019-00381-9DOI Listing
February 2019
1 Read

Ginger potentiates the effects of silymarin on liver fibrosis induced by CCL4: the role of galectin-8.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):885-891

Department of Biochemistry, Faculty of Pharmacy, Damanhour University, Egypt.

Objective: The liver is an important organ that is actively involved in metabolic functions and targeted by a number of toxicants. Galectin-8 (Gal-8) is downregulated in liver fibrosis. Reduced Gal-8 expression correlates with inflammation and metastasis. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16903DOI Listing
January 2019

Non-Operative Management of Blunt Liver Trauma: Safety, Efficacy and Complications of a Standardized Treatment Protocol.

Bull Emerg Trauma 2019 Jan;7(1):49-54

Department of Surgery, A. Cardarelli Hospital, Via A. Cardarelli 9 80131 Naples, Italy.

Objective: To evaluate the safety and effectiveness of NOM (non-operative management) in the treatment of blunt liver trauma, following a standardized treatment protocol.

Methods: All the hemodynamically stable patients with computed tomography (CT) diagnosis of blunt liver trauma underwent NOM. It included strict clinical and laboratory observation, 48-72h contrast enhanced ultrasonography (CEUS) or CT follow-up, a primary angioembolization in case of admission CT evidence of vascular injuries and a secondary angioembolization in presence of vascular injuries signs at follow-up CEUS. Read More

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http://dx.doi.org/10.29252/beat-070107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360015PMC
January 2019

Stereological Comparison of Imbibed Fibrinogen Gauze versus Simple Gauze in External Packing of Grade IV Liver Injury in Rats.

Bull Emerg Trauma 2019 Jan;7(1):41-48

Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: To evaluate the effect of imbibed fibrinogen gauze on survival, bleeding and healing in liver trauma.

Methods: This animal experimental study was conducted on 20 adult male Sprague-Dawley rats; with a mean weight of 300±50 gram; divided into two groups. Grade IV injury was induced to the subjects' liver. Read More

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http://dx.doi.org/10.29252/beat-070106.DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360012PMC
January 2019
1 Read

HS inhalation-induced energy metabolism disturbance is involved in LPS mediated hepatocyte apoptosis through mitochondrial pathway.

Sci Total Environ 2019 Jan 28;663:380-386. Epub 2019 Jan 28.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Hydrogen sulfide (HS) is a toxic gas and one of the air pollutants of great concern. High-concentrated HS can induce energy metabolism disturbance and apoptosis. However, the mechanism of HS-induced liver injuries is unknown. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.360DOI Listing
January 2019
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Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.

Toxicol Res (Camb) 2019 Jan 25;8(1):67-76. Epub 2018 Oct 25.

Institute of Toxicology , School of Public Health , Shandong University , Jinan , Shandong Province 250012 , China . Email:

The purpose of the present study was to investigate the effects and underlying mechanisms of diallyl sulfide (DAS), an organosulfur compound extracted from garlic, on drug-induced or chemical-induced liver injury caused by acetaminophen (APAP) or carbon tetrachloride (CCl) in mice. DAS (100, 200, or 400 μmol kg) was orally administered 1 hour before APAP or CCl intraperitoneal injection, and the serum and liver tissue were collected 24 hours after APAP or CCl exposure. The serum aminotransferase activities and liver histopathological examination showed that DAS exhibited obvious hepatoprotective effects against acute liver injury induced by APAP or CCl. Read More

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http://xlink.rsc.org/?DOI=C8TX00185E
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http://dx.doi.org/10.1039/c8tx00185eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334500PMC
January 2019
3 Reads

Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases.

Cytotechnology 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, Cardiovascular Disease Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Mitochondria are attractive cellular organelles which are so interesting in both basic and clinical research, especially after it was found that they were arisen as a bacterial intruder in ancient cells. Interestingly, even now, they are the focus of many investigations and their function and relevance to health and disease have remained open questions. More recently, research on mitochondria have turned out their potential application in medicine as a novel therapeutic intervention. Read More

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http://dx.doi.org/10.1007/s10616-019-00302-9DOI Listing
January 2019
1 Read

[Midterm outcomes of surgical treatment of traumatic severe tricuspid insufficiency].

Zhonghua Wai Ke Za Zhi 2019 Feb;57(2):134-138

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

To investigate the indication and midterm outcomes of surgical treatment of traumatic tricuspid insufficiency. Totally 19 patients with traumatic tricuspid insufficiency who underwent surgical treatment at Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University from January 2002 to January 2018 were included in this retrospective study. There were 12 male and 7 female patients, aged (43. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.02.012DOI Listing
February 2019
1 Read

Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots.

Nanomedicine (Lond) 2019 Feb 30;14(4):431-446. Epub 2019 Jan 30.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Aim: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).

Materials & Methods:  The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0285
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http://dx.doi.org/10.2217/nnm-2018-0285DOI Listing
February 2019
6 Reads

Does β-caryophyllene protect against renal dysfunction following ischemia-reperfusion injury in the rat?

Int J Physiol Pathophysiol Pharmacol 2018 25;10(6):163-171. Epub 2018 Dec 25.

Department of Surgery, College of Medicine & Health Sciences, United Arab Emirates University Al Ain, United Arab Emirates.

Introduction: Renal ischemia-reperfusion injury (IRI) causes renal functional alterations which may lead to permanent renal impairment. β-caryophyllene (BCP), a natural bicyclic sesquiterpene, is an important constituent of many edible plants including spices. It is an FDA-approved food additive which possesses potent anti-inflammatory and antioxidant activities and has been shown to protect against chemotherapeutics-induced organ toxicities and against ischemic injuries to heart, liver and brain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334221PMC
December 2018

Underreporting of Veress Needle Injuries: Comparing Direct Observation and Chart Review Methods.

J Surg Res 2019 Apr 24;236:266-270. Epub 2018 Dec 24.

International Centre for Surgical Safety, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: Adverse events in surgery occur frequently, increase likelihood of postoperative morbidity, and mostly take place in the operating rooms. Several surgeons have advocated for learning from adverse events and near misses to help improve patient safety. To do so, one must first understand how to accurately identify and report intraoperative events. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.039DOI Listing
April 2019
1 Read

Hernia Management in Cirrhosis: Risk Assessment, Operative Approach, and Perioperative Care.

J Surg Res 2019 Mar 23;235:1-7. Epub 2018 Oct 23.

Division of Trauma and Acute Care Surgery, Department of Surgery, UPMC, Pittsburgh, Pennsylvania.

Background: The rising incidence of liver disease has complicated the management of common surgical pathologies. Hernias, in particular, are problematic given the shortage of high-quality data and differing expert opinions. We aim to provide a narrative review of hernia management in cirrhosis as a first step toward developing evidence-based recommendations for the care of these patients. Read More

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http://dx.doi.org/10.1016/j.jss.2018.09.052DOI Listing

Evaluation of Fasciola hepatica Infections in Cattle in Northeastern Algeria and the Effects on Both Enzyme and Hepatic Damage, Confirmed by Scanning Electron Microscopy.

Acta Parasitol 2019 Jan 28. Epub 2019 Jan 28.

Laboratoire de Parasitologie et Mycologie, Centre Hospitalo-Universitaire Mustapha Pacha, Place du 1er Mai, Alger, Algeria.

Purpose: The aim of our study is to establish the presence of Fasciola hepatica on farms in northeastern Algeria.

Methods: 143 blood and coprological samples of 15 males and 128 females of different breeds and ages were analysed.

Results: Our study indicates a heterogeneous level of the anti-f2 antibodies to Fasciola hepatica in response to the infection. Read More

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http://link.springer.com/10.2478/s11686-018-00013-9
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http://dx.doi.org/10.2478/s11686-018-00013-9DOI Listing
January 2019
3 Reads

Galectin-9 Alleviates LPS-Induced Preeclampsia-Like Impairment in Rats via Switching Decidual Macrophage Polarization to M2 Subtype.

Front Immunol 2018 10;9:3142. Epub 2019 Jan 10.

Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Dysfunction of decidual macrophages (DMs) is considered a critical event in the pathogenesis of pre-eclampsia (PE). T cell immunoglobulin mucin 3 (Tim-3) is an important negative regulatory molecule that induces immune tolerance by interacting with its ligand Galectin-9 (Gal-9) and thus modulating function of various immune cells, including macrophages. However, the regulatory effects of Tim-3/Gal-9 signaling on DMs polarization and its role in PE remain unclear. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335255PMC
January 2019
1 Read

Development and validation of a new simplified anatomic trauma mortality score.

Injury 2019 Jan 17. Epub 2019 Jan 17.

Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Malaysia. Electronic address:

Background: Most trauma mortality prediction scores are complex in nature. GAP (Glasgow Coma Scale, Age, Systolic blood pressure) and mGAP (mechanism, Glasgow Coma Scale, Age, Systolic blood pressure) scores are relatively simple scoring tools. However, these scores were not validated in low and middle income countries including Malaysia and its accuracies are influenced by the fluctuating physiologic parameters. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.027DOI Listing
January 2019

Commemorating 50 years since the first heart transplantation in Bratislava - Czechoslovakia.

Authors:
G Silvay

Bratisl Lek Listy 2019 ;120(1):3-8

The first human-to-human heart transplantation in Czechoslovakia, and the 25th transplantation in the world, was performed in Bratislava, the second largest city in Czechoslovakia on July 9, 1968. The operation was carried out by a team led by Professors Karol Siska and Ladislav Kuzela at the second Surgical Clinic at the Comenius University of the Medical Faculty in Bratislava, Partizanska Street-only seven months after the first heart transplantation performed by Dr. Christiaan Barnard in Cape Town. Read More

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http://dx.doi.org/10.4149/BLL_2019_001DOI Listing
January 2019

[Research advances of autoimmune liver diseases in 2018].

Authors:
Y Chen Q X Wang X Ma

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):14-17

Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine;Institute of Digestive Disease, Shanghai 200001, China.

Autoimmune liver disease is a group of hepatobiliary injuries mediated by abnormal immunity. It mainly includes autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Recently, an advancement of diagnostic technology has improved the detection and treatment of autoimmune hepatitis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2019.01.005DOI Listing
January 2019
2 Reads

Laparoscopic subtotal cholecystectomy for Mirizzi syndrome: A report of a case.

Int J Surg Case Rep 2019 Jan 19;55:32-34. Epub 2019 Jan 19.

Department of Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, Chiba, Japan. Electronic address:

Introduction: Mirizzi syndrome is a rare complication of gallstone disease. The purpose of this report is to describe the utility of laparoscopic subtotal cholecystectomy for Mirizzi syndrome.

Presentation Of Case: A 53-year-old female presented with dark urine and right upper quadrant pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193002
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http://dx.doi.org/10.1016/j.ijscr.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351350PMC
January 2019
5 Reads

Visceral Injuries in Patients with Blunt and Penetrating Abdominal Trauma Presenting to a Tertiary Care Facility in Karachi, Pakistan.

Cureus 2018 Nov 17;10(11):e3604. Epub 2018 Nov 17.

General Surgery, Jinnah Postgraduate Medical College, Karachi, PAK.

Introduction Abdominal injuries are responsible for 10% of the mortalities due to trauma. Delays in early diagnosis or misdiagnoses are two major reasons for the mortality and morbidity associated with abdominal trauma. The objectives of this study were to determine the frequency of visceral injuries in patients with abdominal trauma and compare the frequency of visceral injuries in patients with blunt and penetrating abdominal trauma. Read More

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http://dx.doi.org/10.7759/cureus.3604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338406PMC
November 2018

Protective effects of genistein and melatonin on mouse liver injury induced by whole-body ionising radiation.

Mol Clin Oncol 2019 Feb 11;10(2):261-266. Epub 2018 Dec 11.

Department of Medical Pathology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.

The aim of the present study was to investigate the effectiveness of melatonin and genistein in preventing radiation therapy (RT)-induced liver injury in mice. A total of 70 Swiss Albino male mice were divided into 7 equal groups (n=10/group) as follows: Melatonin (M group, G3), genistein (G group, G4), polyethylene glycol-400 (P group, G5), RT only (RT group, G2) and sham irradiation (C group, G1). RT plus genistein (RT+G group, G7) and RT plus melatonin (RT+M group, G6) were the co-treatment groups. Read More

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http://dx.doi.org/10.3892/mco.2018.1790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327223PMC
February 2019

Hepatoprotective effects of blue honeysuckle on CCl-induced acute liver damaged mice.

Food Sci Nutr 2019 Jan 27;7(1):322-338. Epub 2018 Nov 27.

Department of Food and Nutrition College of BioNano Technology Gachon University Seongnam-si Gyeonggi-do Korea.

The objective of this study was to evaluate the hepatoprotective effects of blue honeysuckle (BH) on carbon tetrachloride (CCl)-induced acute hepatic damage in mice. The experiment used a total of 60 ICR mice, which were divided into six groups. Except for the intact control groups, all groups received a single intraperitoneal injection of CCl after a 7 day pre-treatment period with distilled water, BH extracts, or silymarin. Read More

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http://doi.wiley.com/10.1002/fsn3.893
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http://dx.doi.org/10.1002/fsn3.893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341158PMC
January 2019
4 Reads

Intravenous injection of post-hemorrhagic shock mesenteric lymph induces multiple organ injury in rats.

Exp Ther Med 2019 Feb 5;17(2):1449-1455. Epub 2018 Dec 5.

Institute of Microcirculation, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China.

Post-hemorrhagic shock mesenteric lymph (PHSML) has an important role in the multiple organ injuries caused by severe shock. The current study investigated whether intravenous injection of PHSML induces organ injury in normal rats. Following the establishment of hemorrhagic shock in donor rats (40±2 mmHg, 3 h), PHSML was drained during hypotension at 1-3 h and then injected to normal rats through the femoral vein within 30 min. Read More

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http://dx.doi.org/10.3892/etm.2018.7048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327623PMC
February 2019
1 Read

Use of blood clotting assays to assess potential anticoagulant rodenticide exposure and effects in free-ranging birds of prey.

Sci Total Environ 2019 Mar 3;657:1205-1216. Epub 2018 Dec 3.

Environment and Climate Change Canada, Science & Technology Branch, Pacific Wildlife Research Centre, Delta V4K 3N2, BC, Canada. Electronic address:

Non-target wildlife, particularly birds of prey, are widely exposed to and acutely poisoned by anticoagulant rodenticides (ARs). An unresolved issue surrounding such exposure, however, is the potential for sublethal effects. In particular, the consequences of AR exposure and resulting coagulopathy on health and survival of unintentionally exposed animals, which often encounter a multitude of anthropogenic stressors, are understudied. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.485DOI Listing

Pediatric Handlebar Injuries: More Than Meets the Abdomen.

Pediatr Emerg Care 2019 Jan 21. Epub 2019 Jan 21.

Division of Pediatric Radiology, Department of Radiology, Indiana University School of Medicine.

Objectives: Injuries associated with bicycles can generally be categorized into 2 types: injuries from falling from/off bicycles and injuries from striking the bicycle. In the second mechanism category, most occur as a result of children striking their body against the bicycle handlebar. The purpose of this study was to evaluate the presentation, body location, injury severity, and need for intervention for pediatric handlebar injuries at a single level one pediatric trauma center and contrast these against other bicycle-related injuries in children. Read More

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http://Insights.ovid.com/crossref?an=00006565-900000000-9824
Publisher Site
http://dx.doi.org/10.1097/PEC.0000000000001690DOI Listing
January 2019
8 Reads

Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice.

Shock 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Division of GI, Trauma and Endocrine Surgery, and Burn Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045.

Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health. Traumatic injury, such as burn, elicits a number of changes in the gut, including a shift in the composition of the microbiome (dysbiosis), increased gut leakiness, and bacterial translocation into the lymphatic system and bloodstream. These effects are believed to contribute to devastating secondary complications following burn, including pneumonia, acute respiratory distress syndrome, multi-organ failure, and septic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001321DOI Listing
January 2019
12 Reads

Clamp-Crush Technique Versus Harmonic Scalpel for Hepatic Parenchymal Transection in Living Donor Hepatectomy: a Randomized Controlled Trial.

J Gastrointest Surg 2019 Jan 22. Epub 2019 Jan 22.

Liver Transplantation Unit, Gastrointestinal Surgery Center, Department of Surgery, College of Medicine, Mansoura University, Gastrointestinal Surgery Center, Gehan Street, Mansoura, 35516, Egypt.

Background: Hepatic parenchymal transection is the most invasive step in donor operation. During this step, blood loss and unintended injuries to the intrahepatic structures and hepatic remnant may occur. There is no evidence to prove the ideal techniques for hepatic parenchymal transection. Read More

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http://dx.doi.org/10.1007/s11605-019-04103-5DOI Listing
January 2019
1 Read

The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis.

Biol Open 2019 Feb 11;8(2). Epub 2019 Feb 11.

Department of Pediatrics, Cincinnati Children's Research Foundation, Cincinnati, Ohio 45229, USA

Hepatic fibrosis is the common end stage to a variety of chronic liver injuries and is characterized by an excessive deposition of extracellular matrix (ECM), which disrupts the liver architecture and impairs liver function. The fibrous lesions are produced by myofibroblasts, which differentiate from hepatic stellate cells (HSC). The myofibroblast's transcriptional networks remain poorly characterized. Read More

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http://dx.doi.org/10.1242/bio.039800DOI Listing
February 2019

Preventive Effect of Alkaloids from on Acute Liver Injury in Mice.

Foods 2019 Jan 19;8(1). Epub 2019 Jan 19.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.

is a traditional Chinese food that can be used as a beverage. In this study, three kinds of from different regions of China were selected to observe the preventive effects of extracted alkaloids on CCl₄-induced liver injuries. Animal experiments revealed that alkaloids extracted from decreased the serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), and TBIL (total bilirubin) levels, enhanced SOD (superoxide dismutase) activity, and reduced MDA (malondialdehyde) level in the liver tissues of mice with liver injury. Read More

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http://dx.doi.org/10.3390/foods8010036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352077PMC
January 2019

The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition.

Phytomedicine 2019 Feb 3;53:263-273. Epub 2018 Sep 3.

College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address:

Background: Sedum sarmentosum, which is recorded in Chinese Pharmacopoeia, has been applied clinically to treat liver and gallbladder diseases.

Purpose: This study aimed to explore the hepatoprotective effect of S. sarmentosum less polar extract (SSE) against ANIT-induced liver injury in rats, and the protective activity and mechanism of one major constituent isolated from this extract on D-GalN-induced human hepatic QSG7701 cell damage. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.09.023DOI Listing
February 2019

Comparative analysis of toxic components in different medicinal parts of Gynura japonica and its toxicity assessment on mice.

Phytomedicine 2018 Jul 2;54:77-88. Epub 2018 Jul 2.

The Ministry of Education Key Laboratory for Standardization of Chinese Medicines and the State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; Shanghai R & D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China. Electronic address:

Background: The roots of Gynura japonica are used as traditional medicine for treating blood stasis or traumatic injury even though hundreds of hepatic sinusoidal obstruction syndrome cases have been reported after consumption of the roots, which contain large amounts of hepatotoxic pyrrolizidine alkaloids (HPAs). However, no information is available about the toxic compounds in the aerial parts of G. japonica, which are also used as herbal medicines and even vegetables in several areas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183020
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http://dx.doi.org/10.1016/j.phymed.2018.06.015DOI Listing
July 2018
10 Reads

Stopping immunosuppressive treatment in autoimmune hepatitis (AIH): Is it justified (and in whom and when)?

Liver Int 2019 Jan 22. Epub 2019 Jan 22.

Liver Unit, Northern General Hospital, Sheffield Teaching Hospital's NHS Foundation Trust, Sheffield, UK.

Background: Initial treatment of autoimmune hepatitis (AIH) with prednisolone ± azathioprine is based on randomised controlled trials. Many patients receive long-term immunosuppressive treatment to prevent disease relapse; this strategy has a weaker evidence base.

Aim: To consider whether immunosuppressive treatment (IST) withdrawal in AIH is justified and to develop a rationale for patient selection. Read More

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http://doi.wiley.com/10.1111/liv.14051
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http://dx.doi.org/10.1111/liv.14051DOI Listing
January 2019
7 Reads

Lung ultrasound findings in congenital diaphragmatic hernia.

Eur J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Division of Neonatology, Careggi University Hospital of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 2500 to 5000 infants. The use of lung ultrasound (LUS) for its diagnosis has been reported in only two case reports. The aim of this study was to report the LUS pattern of CDH in a case series of infants with respiratory distress. Read More

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http://dx.doi.org/10.1007/s00431-019-03321-yDOI Listing
January 2019
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Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review.

Respir Med 2019 Jan 12;146:81-86. Epub 2018 Dec 12.

Avera McKennan Hospital & University Health Center: Avera Medical Group Transplant & Liver Surgery, Sioux Falls, SD, USA.

Pulmonary infections are frequent complications in abdominal solid-organ transplantation (aSOT) which may threaten patient and allograft survival. Accurate diagnosis and treatment of pulmonary infections in this population can be challenging. Immunosuppressive therapy not only increases the risk of acquiring opportunistic and non-opportunistic infections, but it also impairs the inflammatory responses associated with microbial invasion which in an otherwise normal host produce clinical and radiologic responses that allow for early identification of the offending pathogen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183038
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http://dx.doi.org/10.1016/j.rmed.2018.12.002DOI Listing
January 2019
3 Reads

Organ transplantation and gut microbiota: current reviews and future challenges.

Am J Transl Res 2018 15;10(11):3330-3344. Epub 2018 Nov 15.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology 13 Hangkong Road, Wuhan 430030, China.

Organ transplantation is often the only effective treatment for patients with end-stage diseases, such as heart, liver, kidney and small bowel failure and is carried out frequently worldwide. Still the post-transplantation complications remain health- and life-threatening outcome that needed to be resolved. With the rapid development of molecular technologies in recent years, more and more researchers realize that the gut microbiota may play a critical role in human diseases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291689PMC
November 2018
6 Reads

Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation.

Circ J 2019 Jan 18. Epub 2019 Jan 18.

Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China.

Background: Recent studies have suggested that pregnancy-associated plasma protein-A (PAPP-A) is involved in the pathogenesis of atherosclerosis. This study aim is to investigate the role and mechanisms of PAPP-A in reverse cholesterol transport (RCT) and inflammation during the development of atherosclerosis. Methods and Results: PAPP-A was silenced in apolipoprotein E (apoE) mice with administration of PAPP-A shRNA. Read More

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https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_C
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http://dx.doi.org/10.1253/circj.CJ-18-0700DOI Listing
January 2019
3 Reads

Immune thrombocytopenic purpura presenting with spontaneous gingival haemorrhage in pregnancy.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, The Queen Elizabeth Hospital, Birmingham, UK.

Gingival bleeding is a common intraoral finding, typically associated with inflamed tissues and periodontal disease. It is easily provoked by periodontal probing or toothbrushing. Spontaneous gingival bleeding rarely occurs and may be the only sign of systemic bleeding problems such as thrombocytopenia, leukaemia or coagulopathy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228309DOI Listing
January 2019
9 Reads

Evaluation of intra-abdominal solid organ injuries in children.

Acta Biomed 2019 Jan 15;89(4):505-512. Epub 2019 Jan 15.

.

Aim: In our study we investigated characteristics and degree of intra-abdominal solid organ injuries according to tomographic imaging in pediatric patients who presented to our emergency clinic with possible abdominal injuries and to whom US and/or abdominal tomography were applied.

Materials And Methods: 1066 pediatric patients were included in the study. The age, gender, injury localization, injury type, injury mechanism, abdominal US and CT results, and treatment specifics of patients were evaulated. Read More

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http://dx.doi.org/10.23750/abm.v89i4.5983DOI Listing
January 2019

Abdominal injuries treated in a referral hospital: analysis of outcomes, treatment approaches, and prognostic scales.

Emergencias 2019 Ene;31(1):15-20

Servicio de Cirugía General y Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Objectives: To describe the abdominal injuries treated in our hospital. We assessed the behavior and reliability of prognostic scales, analyzing the correlations between them and therapeutic decisions and outcomes.

Material And Methods: Retrospective study including all patients with major abdominal injuries admitted to our hospital between 2009 and 2015. Read More

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January 2019
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Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.

Int J Mol Sci 2019 Jan 16;20(2). Epub 2019 Jan 16.

Siegfried Weller Institute, BG Trauma Clinic, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.

Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was to modify liver cancer cell lines in order to improve their drug-metabolizing activities towards PHH. It is well-known that epigenetics is strongly modified in tumor cells and that epigenetic regulators influence the expression and function of Cytochrome P450 (CYP) enzymes through altering crucial transcription factors responsible for drug-metabolizing enzymes. Read More

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http://dx.doi.org/10.3390/ijms20020347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358789PMC
January 2019
1 Read