24,951 results match your criteria Liver Trauma


Geriatric Polytrauma-Cardiovascular and Immunologic Response in a Murine Two-Hit Model of Trauma.

J Surg Res 2019 Apr 21;241:87-94. Epub 2019 Apr 21.

Department of Orthopaedic Trauma, RWTH Aachen University, Aachen, Germany.

Background: The aims of the present study were to establish a clinically relevant two-hit model with trauma/hemorrhage followed by sepsis in older mice and investigate age-dependent cardiovascular and immunologic specificities under these conditions.

Materials And Methods: In aged mice (12, 18, and 24 mo old), a femur fracture followed by hemorrhage was induced. After resuscitation, animals were monitored for 72 h before sepsis was induced. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193016
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http://dx.doi.org/10.1016/j.jss.2019.03.053DOI Listing
April 2019
1 Read

Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis.

Methods Mol Biol 2019 ;1981:237-247

Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Cholestatic liver disease covers a range of biliary disorders marked by an impaired bile duct flow. Various conditions can result in bile obstruction including choledocholithiasis, surgical trauma, and autoimmune disorders. Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_15DOI Listing
January 2019

Anti-interferon-α receptor 1 antibodies attenuate inflammation and organ injury following hemorrhagic shock.

J Trauma Acute Care Surg 2019 May;86(5):881-890

From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.

Background: Hemorrhagic shock (HS) is a life-threatening condition resulting from rapid and significant loss of intravascular volume, leading to hemodynamic instability and death. Inflammation contributes to the multiple organ injury in HS. Type I interferons (IFNs), such as IFN-α and IFN-β, are a family of cytokines that regulate the inflammatory response through binding to IFN-α receptor (IFNAR) which consists of IFNAR1 and IFNAR2 chains. Read More

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http://dx.doi.org/10.1097/TA.0000000000002214DOI Listing

Damage control orthopedics applied in an 8-year-old child with life-threatening multiple injuries: A CARE-compliant case report.

Medicine (Baltimore) 2019 Apr;98(16):e15294

University Children's Hospital Basel (UKBB), Department of Pediatric Surgery, 4056 Basel.

Rationale: Damage control is a staged surgical approach to manage polytraumatized patients. The damage control approach comprises three steps. First, bleeding is controlled and fractures are stabilized temporarily; second, vital parameters are stabilized and the child is rewarmed in the intensive care unit; and third, the child is reoperated for definitive repair of injuries. Read More

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http://Insights.ovid.com/crossref?an=00005792-201904190-0005
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http://dx.doi.org/10.1097/MD.0000000000015294DOI Listing
April 2019
2 Reads

Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales.

Lancet Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. Electronic address:

Background: Prosthetic joint infection is a devastating complication of knee replacement. The risk of developing a prosthetic joint infection is affected by patient, surgical, and health-care system factors. Existing evidence is limited by heterogeneity in populations studied, short follow-up, inadequate power, and does not differentiate early prosthetic joint infection, most likely related to the intervention, from late infection, more likely to occur due to haematogenous bacterial spread. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30755-2DOI Listing

Gene expression, genotoxicity, and physiological responses in an Amazonian fish, Colossoma macropomum (CUVIER 1818), exposed to Roundup® and subsequent acute hypoxia.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Ecophysiology and Molecular Evolution (LEEM), Brazilian National Institute of Amazonian Research (INPA), 69067-375, André Araújo Avenue, 2936, Petrópolis, Manaus, AM, Brazil.

Roundup® (RD) is a glyphosate-based herbicide used to control weeds in agriculture, and fishponds. In the Amazon, hypoxia is a natural phenomenon in flooded areas. Beyond the challenge of hypoxia, fish need to cope with the use of pesticides as RD that increases in the aquatic environment through the leaching of agricultural areas, and in aquaculture fish tanks. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.04.010DOI Listing
April 2019
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Innate immune cells orchestrate the repair of sterile injury in the liver and beyond.

Eur J Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

There is a close association between inflammation and sterile injury, however not all sterile injuries are the same. While a regulated inflammatory response is crucial for proper healing, a dysregulated or non-terminating response leads to disrepair. While immune cells are thought to contribute to the disrepair, they may also be critical for proper healing and as such their actions may dictate the end result. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184748
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http://dx.doi.org/10.1002/eji.201847485DOI Listing
April 2019
1 Read

The combined effect of surgeon and hospital volume on health outcomes: a systematic review.

Clin Ter 2019 Mar-Apr;170(2):e148-e161

Objectives: To explore the interaction between surgeon volumes (SVs) and hospital volumes (HVs) on health outcomes.

Materials And Methods: We searched MEDLINE, Embase, CINAHL, Web of Science as of May 2017. We included studies investigating the interaction between high or low SVs operating in high or low HVs. Read More

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http://dx.doi.org/10.7417/CT.2019.2125DOI Listing
April 2019
1 Read

Characteristics of Nonpulmonary Organ Dysfunction at Onset of ARDS Based on the Berlin Definition.

Respir Care 2019 Apr 16. Epub 2019 Apr 16.

Department of Pulmonary and Critical Care Medicine, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.

Background: The Berlin definition of ARDS does not account for nonpulmonary organ failure, which is a major determinant of outcome. We examined whether an increasing severity of hypoxemia across the Berlin definition classifications also corresponded with evidence of multiple organ dysfunction on the day of ARDS onset. We also examined the representation of major etiologies for ARDS across the Berlin definition classifications. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06165
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http://dx.doi.org/10.4187/respcare.06165DOI Listing
April 2019
2 Reads

NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.

FASEB J 2019 Apr 16:fj201801881RR. Epub 2019 Apr 16.

Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Damage-induced long noncoding RNA (DINO) is a long noncoding RNA that directly interacts with p53 and thereby enhances p53 stability and activity in response to various cellular stresses. Here, we demonstrate that nuclear receptor subfamily 2 group E member 3 (NR2E3) plays a crucial role in maintaining active DINO epigenetic status for its proper induction and subsequent p53 activation. In acetaminophen (APAP)- or carbon tetrachloride-induced acute liver injuries, NR2E3 knockout (KO) mice exhibited far more severe liver injuries due to impaired DINO induction and p53 activation. Read More

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https://www.fasebj.org/doi/10.1096/fj.201801881RR
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http://dx.doi.org/10.1096/fj.201801881RRDOI Listing
April 2019
2 Reads

The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.

Background/aims: The proton pump inhibitor lansoprazole (LPZ) is clinically used to reduce gastric acid secretion, but little is known about its possible hepatoprotective effects. This study aimed to investigate the hepatoprotective effects of LPZ and its potential mechanisms using in vitro and in vivo rat models of liver injury.

Methods: For the in vitro model of liver injury, primary cultured rat hepatocytes were treated with interleukin-1β in the presence or absence of LPZ. Read More

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http://dx.doi.org/10.1007/s10620-019-05622-6DOI Listing
April 2019
1 Read

PREOPERATIVE ASSESSMENT OF MUSCLE MASS USING COMPUTERIZED TOMOGRAPHY SCANS TO PREDICT OUTCOMES FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION.

Transplantation 2019 Apr 10. Epub 2019 Apr 10.

Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.

Background: Sarcopenia is an established risk factor predicting survival in chronically ill and trauma patients. We herein examine the assessment and clinical implication of sarcopenia in liver transplantation (LT).

Methods: Computerized tomography (CT) scans from 172 patients waitlisted for LT were analysed applying six morphometric muscle scores, including two density indices [Psoas Density (PD), Skeletal Muscle Density (SMD)] and four scores based on muscle area [total psoas area (TPA), psoas muscle index (PMI), skeletal muscle area (SMA), skeletal muscle index (SMI)]. Read More

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http://dx.doi.org/10.1097/TP.0000000000002759DOI Listing
April 2019
7 Reads

Pre-hospital adenosine, lidocaine and magnesium has inferior survival compared to tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock.

J Trauma Acute Care Surg 2019 Apr 12. Epub 2019 Apr 12.

Naval Medical Research Unit San Antonio, JBSA-Ft. Sam Houston, TX.

Background: Adenosine, lidocaine, and magnesium (ALM) is a cardioplegic agent shown to improve survival by improving cardiac function, tissue perfusion, and coagulopathy in animal models of shock. We hypothesized pre-hospital ALM treatment in hemorrhagic shock would improve survival compared to current Tactical Combat Casualty Care (TCCC) resuscitation beyond the Golden Hour.

Methods: Swine were randomized to: 1) TCCC, 2) 2cc/kg vehicle control (VC), 3) 2cc/kg ALM+drip, 4) 4cc/kg ALM+drip, 5) 4cc/kg ALM+delayed drip at 0. Read More

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http://dx.doi.org/10.1097/TA.0000000000002308DOI Listing
April 2019
2 Reads

A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1496-1504

a State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital , Third Military Medical University (Army Medical University) , Chongqing , P.R. China.

Pathological hypoxia-induced organ dysfunction contributes to the high mortality of sepsis. Because of the microcirculation dysfunction following severe sepsis, it is difficult for erythrocytes to transport oxygen to hypoxic tissues. Haemoglobin-based oxygen carriers (HBOCs) are capable of delivering oxygen to hypoxic tissues. Read More

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http://dx.doi.org/10.1080/21691401.2019.1602049DOI Listing
December 2019
1 Read

Advanced cadaver-based educational seminar for trauma surgery using saturated salt solution-embalmed cadavers.

Acute Med Surg 2019 Apr 20;6(2):123-130. Epub 2019 Jan 20.

Department of Anatomy Tokyo Medical University Tokyo Japan.

Aim: Senior surgeons in Japan who participated in "cadaver-based educational seminar for trauma surgery (CESTS)" subsequently stated their interest in seminars for more difficult procedures. Therefore, we held a 1-day advanced-CESTS with saturated salt solution (SSS)-embalmed cadavers and assessed its effectiveness for surgical skills training (SST).

Methods: Data were collected from three seminars carried out from September 2015 to January 2018, including a 10-point self-assessment of confidence levels (SACL) questionnaire on nine advanced surgical skills, and evaluation of seminar content before, just after, and half a year after the seminar. Read More

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http://dx.doi.org/10.1002/ams2.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442534PMC

Liver transplantation following hepatic artery avulsion in a trauma patient.

J Surg Case Rep 2019 Apr 6;2019(4):rjz063. Epub 2019 Apr 6.

Department of General and Digestive Surgery, Cruces University Hospital, Plaza Cruces s/n, 48903, Barakaldo, Vizcaya, Spain.

Background: Hepatic artery avulsion following politrauma is an extremely rare condition with a very high mortality rate. Management is based on damage control surgery given the precarious situation of these patients. Ligating the artery is one option under such circumstances, despite potential consequences including ischemic cholangiopathy (IC). Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz06
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http://dx.doi.org/10.1093/jscr/rjz063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451184PMC
April 2019
3 Reads

Investigation of Frequency of the Lethal Triad and Its 24 Hours Prognostic Value among Patients with Multiple Traumas.

Open Access Maced J Med Sci 2019 Mar 26;7(6):962-966. Epub 2019 Mar 26.

Department of Emergency Medicine, Orthopedic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Death in multiple trauma (MT) patients is one of the serious concerns of the medical service provider. Any prediction of the likelihood of death on the assessment of the patient's condition is performed using different variables, one of the tools in the triage of patients to determine their condition.

Aim: We aimed to investigate the frequency and the predictive value of death in 24 hours triad of death in patients qualified with multiple traumas admitted to Imam Khomeini hospital. Read More

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http://dx.doi.org/10.3889/oamjms.2019.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454176PMC
March 2019
1 Read

microRNA-30a inhibits the liver cell proliferation and promotes cell apoptosis through the JAK/STAT signaling pathway by targeting SOCS-1 in rats with sepsis.

J Cell Physiol 2019 Apr 10. Epub 2019 Apr 10.

Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Shenzhen, People's Republic of China.

Sepsis is a systemic inflammatory response that may be induced by trauma, infection, surgery, and burns. With the aim of discovering novel treatment targets for sepsis, this current study was conducted to investigate the effect and potential mechanism by which microRNA-30a (miR-30a) controls sepsis-induced liver cell proliferation and apoptosis. Rat models of sepsis were established by applying the cecal ligation and puncture (CLP) method to simulate sepsis models. Read More

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http://dx.doi.org/10.1002/jcp.28410DOI Listing
April 2019
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Selective non-operative management for penetrating splenic trauma: a systematic review.

Eur J Trauma Emerg Surg 2019 Apr 10. Epub 2019 Apr 10.

Department of Trauma, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Introduction: The treatment of abdominal solid organ injuries has shifted towards non-operative management (NOM). However, the feasibility of NOM for penetrating splenic trauma is unclear and outcome is believed to be worse than NOM for penetrating liver and kidney injuries. Hence, the aim of the current systematic review was to evaluate the feasibility of selective NOM in penetrating splenic injury. Read More

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http://link.springer.com/10.1007/s00068-019-01117-1
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http://dx.doi.org/10.1007/s00068-019-01117-1DOI Listing
April 2019
2 Reads

Posttransplant epithelioid inflammatory myofibroblastic sarcoma: A case report.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):303-305

Department of Histopathology, Apollo Hospital, New Delhi, India.

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare entity and a novel variant of inflammatory myofibroblastic tumor (IMT), usually seen in children and nonsmoking young adults. Their occurrence in a posttransplant setting is still rare. These tumors are characterized by prominent epithelioid morphology, large histiocytoid "Reed Sternberg"-like cell, unique pattern of ALK immuno-reactivity, and aggressive clinical behavior. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_284_17DOI Listing
April 2019
1 Read

Intraperitoneal rupture of the hydatid cyst: Four case reports and literature review.

World J Hepatol 2019 Mar;11(3):318-329

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.

Background: Most patients with hydatid cysts are asymptomatic, and they are diagnosed incidentally during radiological evaluations performed for other reasons. However, some patients develop symptoms and complications due to cyst size, location, and the relationship between the cyst and adjacent structures. The most serious complications that can occur are rupture of the cysts into the biliary tract, vascular structures, hollow viscus, and peritoneal cavity. Read More

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http://dx.doi.org/10.4254/wjh.v11.i3.318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447420PMC
March 2019
1 Read

SHMT2 Promotes Liver Regeneration Through Glycine-activated Akt/mTOR Pathway.

Transplantation 2019 Apr 4. Epub 2019 Apr 4.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The development of liver transplantation (LT) is increasingly being limited by the unavailability of liver grafts. Unique regenerative capacity of liver in response to injuries makes living donor liver transplantation (LDLT) a feasible strategy to meet clinical demands. Serine hydroxymethyl-transferase 2 (SHMT2) serves as the key enzyme in the biosynthesis of glycine. Read More

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http://dx.doi.org/10.1097/TP.0000000000002747DOI Listing
April 2019
1 Read

Hydrodissection of the Gallbladder Bed: A Technique for Ablations Located Close to the Gallbladder.

Cardiovasc Intervent Radiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Interventional Radiology, Nouvel Hôpital Civil, 1, place de l'hôpital, 67096, Strasbourg Cedex, France.

Objective: To report the technique of hydrodissection of the gallbladder bed, in order to separate the gallbladder wall from the liver surface during microwave ablation of liver malignancies located in segment V.

Materials And Methods: Between January 2018 and March 2018, percutaneous hydrodissection of the gallbladder fossa was performed during four microwave ablation procedures in three patients (One patient was treated twice for the same lesion, making a total of four procedures for three lesions.) All treated lesions were located in segment V and abutting the gallbladder. Read More

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http://dx.doi.org/10.1007/s00270-019-02218-5DOI Listing

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Midline gallbladder makes a challenge for surgeons during laparoscopic cholecystectomy; case series of 6 patients.

Ann Med Surg (Lond) 2019 Apr 12;40:14-17. Epub 2019 Mar 12.

University of Duhok, College of Medicine Azadi Teaching Hospital, 8 Nakhoshkhana Road, 1014, AM, Duhok City, DUHOK, Iraq.

Introduction: Gall bladder anomalies varies from variations in the size, site, duct systems, and shape. Abnormal location comprises the commonest one.The presence of an ectopic gall bladder is estimated to occur in around 0. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423301PMC
April 2019
1 Read

Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels.

Antimicrob Agents Chemother 2019 Apr 8. Epub 2019 Apr 8.

Section of Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Caspofungin has a liver-dependent metabolism. Reduction of the dose is recommended based on Child-Pugh (C-P) score. In critically ill patients drug pharmacokinetics (PK) may be altered. Read More

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http://dx.doi.org/10.1128/AAC.02466-18DOI Listing
April 2019
1 Read

Duck circovirus induces a new pathogenetic characteristic, primary sclerosing cholangitis.

Comp Immunol Microbiol Infect Dis 2019 Apr 3;63:31-36. Epub 2019 Jan 3.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, PR China. Electronic address:

Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease of unknown cause. In the study, we found that duck circovirus (DuCV) induces PSC in natural and reproductive cases. PSC in DuCV naturally infected ducks was investigated by PCR and histopathology. Read More

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http://dx.doi.org/10.1016/j.cimid.2018.12.009DOI Listing
April 2019
1 Read

Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2.

Pharm Biol 2019 Dec;57(1):125-132

a Department of Biochemistry, Faculty of Sciences , Payame-e-Noor University , Tehran , Iran.

Context: Mentha longifolia L. (Lamiaceae), a traditional medicinal herb, has been highly valued for exhibiting antimicrobial, antioxidant and antispasmodic properties.

Objective: For the first time, the synergetic anti-inflammatory effects of deuterium depleted water (DDW) and M. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461093PMC
December 2019
2 Reads

Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver.

Lipids Health Dis 2019 Apr 6;18(1):87. Epub 2019 Apr 6.

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, No.169, Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.

Background: The homeostasis of lipid droplets (LDs) plays a crucial role in maintaining the physical metabolic processes in cells, and is regulated by many LD-associated proteins, including perilipin 5 (Plin5) in liver. As the putative sites of hepatitis C virus (HCV) virion assembly, LDs are vital to viral infection. In addition, the hepatic LD metabolism can be disturbed by non-structural HCV proteins, such as NS5A, but the details are still inexplicit. Read More

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http://dx.doi.org/10.1186/s12944-019-1022-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451786PMC
April 2019
3 Reads

Bacteria-released outer membrane vesicles promote disseminated intravascular coagulation.

Thromb Res 2019 Mar 28;178:26-33. Epub 2019 Mar 28.

Department of Hematology, The 3rd Xiangya Hospital, Central South University, Changsha, PR China; State Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan Province, PR China; Department of Pathophysiology, School of Basic Medical Science, Jinan University, Guangzhou, Guangdong Province, PR China; Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The 3rd Xiangya Hospital, Central South University, Changsha, PR China. Electronic address:

Introduction: Sepsis is frequently complicated by disseminated intravascular coagulation (DIC), which promotes multiple organ dysfunctions and significantly increase the mortality of patients with sepsis. How bacteria cause DIC is not fully understood. Outer membrane vesicles (OMVs) are membrane-enclosed microvesicles released by variety of bacteria. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.03.019DOI Listing
March 2019
4 Reads

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

J Leukoc Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either active release from cells, or passive release upon lytic cell death. Movement of HMGB1 between cellular compartments is a dynamic process induced by a variety of cell stresses and disease processes, including sepsis, trauma, and hemorrhagic shock. Read More

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http://dx.doi.org/10.1002/JLB.3MIR1218-497RDOI Listing
April 2019
2 Reads

Subcutaneous Injection of Myrrh Essential Oil in Mice: Acute and Subacute Toxicity Study.

Evid Based Complement Alternat Med 2019 3;2019:8497980. Epub 2019 Mar 3.

Wonkwang University, College of Pharmacy, Department of Oriental Pharmacy & Wonkwang Oriental Medicines Research Institute, Iksan, Jeonbuk, Republic of Korea.

Myrrh essential oil (MEO) is widely used as remedies for the different human ailment in different parts of the world. The misuse of this natural product in higher doses may lead to fever, inflammation, and liver and kidney problems. In this study, we performed the acute and subacute toxicity analysis of MEO in mice model after subcutaneous injection and evaluated the safe dose to prevent the possible risk and side effects. Read More

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http://dx.doi.org/10.1155/2019/8497980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421018PMC
March 2019
3 Reads

Phenolic Compounds from Water-Ethanol Extracts of Produced in Cameroon, as Potential Protectors against CCl-Induced Liver Injuries.

ScientificWorldJournal 2019 3;2019:5236851. Epub 2019 Mar 3.

Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box 1364, Yaoundé, Cameroon.

Background: Liver diseases are a global health problem. Medicinal plants are being increasingly used to manage a wide variety of diseases including liver disorders. The aim of this study was to investigate the antioxidant properties and hepatoprotective activity of polyphenolic extract from the fruits of . Read More

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http://dx.doi.org/10.1155/2019/5236851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421029PMC
March 2019
2 Reads
1.219 Impact Factor

DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor.

Exp Oncol 2019 Mar;41(1):26-31

National Cancer Institute, Ministry of Health of Ukraine, Kyiv 03022, Ukraine.

Prognosis of metastatic colorectal cancer (mCRC) patients nowadays is an important subject in the field of oncology. R0-resection of colon with primary tumor and liver metastasis remains the only treatment which significantly improves survival rate. However, recent experimental data show that surgical trauma can indirectly stimulate tumor growth due to mitochondrial dysfunction and unregulated superoxide radical (O2-) generation. Read More

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Hemobilia: historical overview, clinical update, and current practices.

Liver Int 2019 Apr 1. Epub 2019 Apr 1.

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA.

Hemobilia refers to macroscopic blood in the lumen of the biliary tree. It represents an uncommon, but important, cause of gastrointestinal bleeding and can have potentially lethal sequelae if not promptly recognized and treated. The earliest known reports of hemobilia date to the 17 century, but due to its relative rarity and challenges in diagnosis, it has historically not been well-studied. Read More

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http://dx.doi.org/10.1111/liv.14111DOI Listing
April 2019
7 Reads

Use of Interventional Radiology in Critically Injured Children Admitted in a Pediatric Intensive Care Unit of a Developing Country.

Cureus 2019 Jan 19;11(1):e3922. Epub 2019 Jan 19.

Radiology, Aga Khan University Hospital, Karachi, PAK.

Objective The aim of this study was to describe the outcome of the use of interventional radiological procedures (IRP) (angioembolization) in critically injured children. Methods A retrospective review of medical records of all children who underwent an IRP from January 2010 to December 2015 was done. Data were collected on a structured proforma and results are presented as mean with standard deviation and frequency with percentages. Read More

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http://dx.doi.org/10.7759/cureus.3922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426563PMC
January 2019
4 Reads

Molecular Mechanisms for Protection of Hepatocytes against Bile Salt Cytotoxicity.

Chem Pharm Bull (Tokyo) 2019 ;67(4):333-340

Department of Pharmacy, Shiga University of Medical Science Hospital.

Biliary lipids consist mainly of bile salts, phospholipids and cholesterol, which form mixed micelles and vesicles. Bile salts play various physiological roles but have damaging effects on cell membranes due to their detergent properties. The cytotoxicity of bile salts on hepatocytes leads to liver injuries and is largely determined by the bile salt species, the concentrations of bile salts, phospholipids and cholesterol, and the lipid composition of cell membranes. Read More

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http://dx.doi.org/10.1248/cpb.c18-01029DOI Listing
January 2019
2 Reads

[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B].

Yakugaku Zasshi 2019 ;139(4):641-645

Department of Pharmacy, Okayama University Hospital.

We herein present the case of a 66-year-old Japanese man with Fanconi's syndrome. He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles. Renal dysfunction, hypophosphatemia, and increased levels of bone alkaline phosphatase were found by a hematology test after admission for treatment of HCC. Read More

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http://dx.doi.org/10.1248/yakushi.18-00170DOI Listing
April 2019
3 Reads

Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries.

Langenbecks Arch Surg 2019 Mar 30. Epub 2019 Mar 30.

Section for Transplant Surgery, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.

Background: Iatrogenic injuries to vital structures of the liver and posthepatectomy liver failure are associated with high mortality. The current donor situation in Norway allows liver transplantation of patients beyond conventional criteria.

Methods: From 1984 to 2017, a total of 1510 liver transplantations were performed. Read More

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http://dx.doi.org/10.1007/s00423-019-01780-3DOI Listing
March 2019
1 Read
2.160 Impact Factor

Seat-Belt Syndrome as managed in Babcock University Teaching Hospital. A Case Report and Literature Review.

West Afr J Med 2019 Jan-Apr;36(1):75-79

Department of Surgery, Babcock University Teaching Hospital - Ilisan Remo, Ogun State - Nigeria.

Background: This paper is a case report of a 54 year old woman that presented in our casualty with just "seat belt sign" following a road traffic injury. At laparotomy, she was found to have sustained disastrous internal/visceral injuries with torrential intraperitoneal haemorrhage from the surface of the liver caused by the seat belt. Frantic attempts at haemostasis were proving difficult and time wasting. Read More

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March 2019
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Retrieval Practice or Overall Donor and Recipient Risk: What Impacts on Outcomes After Donation After Circulatory Death Liver Transplantation in the United Kingdom?

Liver Transpl 2019 Apr;25(4):545-558

The Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Parameters of retrieval surgery are meticulously documented in the United Kingdom, where up to 40% of livers are donation after circulatory death (DCD) donations. This retrospective analysis focuses on outcomes after transplantation of DCD livers, retrieved by different UK centers between 2011 and 2016. Donor and recipient risk factors and the donor retrieval technique were assessed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25410
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http://dx.doi.org/10.1002/lt.25410DOI Listing
April 2019
3 Reads

Protective effect of walnut on d-galactose-induced aging mouse model.

Food Sci Nutr 2019 Mar 5;7(3):969-976. Epub 2019 Feb 5.

School of Chinese Materia Medica Yunnan University of Traditional Chinese Medicine Kunming China.

Objective S: Accumulating evidence has suggested that oxidative stress and apoptosis are involved in the aging process. d-galactose (gal) has been reported to cause symptoms of aging in mice, accompanied by liver and brain injuries. Our present work was to study the potential antioxidative and anti-apoptotic effects of walnut and to explore how these effects act on mice in a d-gal-induced aging model. Read More

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http://dx.doi.org/10.1002/fsn3.907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418433PMC

Protective Effects of Facilitated Removal of Blood Alcohol and Acetaldehyde against Liver Injury in Animal Models Fed Alcohol and Anti-HIV Drugs.

Alcohol Clin Exp Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.

Background: We previously developed enzyme nanoparticles (ENP) of alcohol metabolism. This study was to evaluate protective effects of facilitated removal of blood alcohol and/or acetaldehyde on anti-HIV drugs and alcohol-induced liver injuries.

Methods: ENP were prepared for degrading alcohol completely (ENP1) or partially into acetaldehyde (ENP2), which were applied to mice of acute binge or chronic-binge alcohol feeding in the presence of antivirals (ritonavir and lopinavir). Read More

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http://dx.doi.org/10.1111/acer.14034DOI Listing
March 2019
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An Efficacy Comparison of Two Hemostatic Agents in a Porcine Liver Bleeding Model: Gelatin/Thrombin Flowable Matrix versus Collagen/Thrombin Powder.

J Invest Surg 2019 Mar 24:1-11. Epub 2019 Mar 24.

b Baxter Medical Products GmbH , Vienna , Austria.

Purpose: Management of bleeding during surgery can be aided by the application of topical hemostatic agents. This study compared the hemostatic efficacy of a new powder agent containing collagen, chondroitin sulfate, and thrombin (PCCT) with a flowable gelatin-thrombin matrix with smooth particles (SmGM) in a porcine liver bleeding model.

Materials And Methods: Lesions 4-6 mm deep and ∼10 mm in diameter were created in porcine livers and treated with either SmGM or PCCT. Read More

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http://dx.doi.org/10.1080/08941939.2019.1571130DOI Listing
March 2019
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A highly efficient, in situ wet-adhesive dextran derivative sponge for rapid hemostasis.

Biomaterials 2019 Jun 16;205:23-37. Epub 2019 Mar 16.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, PR China. Electronic address:

Uncontrolled hemorrhage is closely related to the high risk of death. However, local hemostats still have various defects and side effects. Herein, an aldehyde dextran (PDA) sponge with proper absorption and adhesion properties is developed for hemorrhage control. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.03.016DOI Listing
June 2019
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Early Complement and Fibrinolytic Activation in a Rat Model of Blast-Induced Multi-Organ Damage.

Mil Med 2019 03;184(Suppl 1):282-290

U.S. Army Institute of Surgical Research, 3698 Chambers Pass Road, Joint Base San Antonio, Fort Sam Houston, TX.

Objective: Blast injury is associated with multi-organ failure (MOF), causing significant morbidity and mortality in trauma patients. However, the pathogenesis of blast-induced MOF still remains obscure. In this study, we evaluate the pathophysiological changes related to blast-induced MOF in a clinically relevant rat model of blast injury. Read More

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http://dx.doi.org/10.1093/milmed/usy412DOI Listing

Direct percutaneous embolization of intestinal lymphatic trunk for chylous ascites management following liver transplant.

Radiol Case Rep 2019 May 7;14(5):608-612. Epub 2019 Mar 7.

University of Kentucky, Department of Radiology, 800 Rose St, Lexington, KY, 40536 USA.

Chylous ascites can be caused by infection, trauma, malignancy, or maybe a complication after major abdominal surgery including liver transplantation. We present a case of a patient who developed chylous ascites following his liver transplantation. He was subsequently treated with direct embolization of lymphatic trunk efferent branches with a mixture of N-butyl cyanoacrylate and lipiodol after the identification of a localized leak on a fluoroscopic lymphangiogram. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409423PMC
May 2019
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Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease.

EBioMedicine 2019 Mar 18. Epub 2019 Mar 18.

Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain; Instituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, 18016 Granada, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Spain. Electronic address:

Background: The vast majority of mitochondrial disorders have limited the clinical management to palliative care. Rapamycin has emerged as a potential therapeutic drug for mitochondrial diseases since it has shown therapeutic benefits in a few mouse models of mitochondrial disorders. However, the underlying therapeutic mechanism is unclear, the minimal effective dose needs to be defined and whether this therapy can be generally used is unknown. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.025DOI Listing

[Retrospective study on the characteristics of early organ injury in elderly patients with severe burns].

Zhonghua Shao Shang Za Zhi 2019 Mar;35(3):163-168

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To analyze the clinical characteristics of early organ injury in elderly patients with severe burns and the effects on the prognosis of patients. From January 2010 to August 2018, 62 patients with severe burns (43 men and 19 women, aged from 60 to 89 years at the time of admission) who were hospitalized in the Institute of Burn Research of the First Affiliated Hospital of Army Medical University (the Third Military Medical University, hereinafter referred to as the author's affiliation), meeting the inclusion criteria, were included in elderly (E) group, and 124 patients with severe burns (86 men and 38 women, aged from 18 to 59 years at the time of admission) at the same term were included in young and middle-aged (YM) group. Treatment of patients in the 2 groups followed the conventional procedures of the author's affiliation. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.03.002DOI Listing
March 2019
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Spontaneous iliopsoas hematoma in a trasfusion dependent β-thalassemia patient with hypersplenism: a case report.

Acta Biomed 2018 Dec 4;90(1):107-111. Epub 2018 Dec 4.

Department of Medical Education Hamad Medical Corporation (HMC), Doha, Qatar.

A 27-year-old married man with transfusion dependent β-thalassemia (TDT) complaining low back pain due to a spontaneous iliopsoas hematoma is reported. A magnetic resonance imaging (MRI) confirmed the diagnosis.The patient was managed conservatively. Read More

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http://dx.doi.org/10.23750/abm.v90i1.7943DOI Listing
December 2018
1 Read