27,496 results match your criteria Liver Trauma


Six gene variants in five children with hypophosphatasia.

Ann Transl Med 2021 May;9(10):888

Department of Endocrinology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Background: Hypophosphatasia (HPP) is a rare hereditary disorder characterized by defective bone and tooth mineralization caused by mutations in the alkaline phosphatase () gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). Here we performed clinical and molecular studies on 5 HPP children to investigate the pathogenic mechanisms of the gene variants.

Methods: Clinical and genetic analyses were performed on 5 HPP children, and the loci where variants were identified. Read More

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Management for traumatic hepatic injury diagnosed by contrast-enhanced ultrasonography in a patient with an occluded coeliac axis: a case report.

J Int Med Res 2021 Jun;49(6):3000605211019926

Department of Radiology, Chungbuk National University Hospital, Cheongju, South Korea.

Transcatheter arterial embolization (TAE) is the standard of care for haemodynamically-stable patients with blunt hepatic injury but it is sometimes impossible due to unfavourable vascular anatomies. This case report describes a 43-year-old male patient with abdominal pain following a motorcycle accident. Based on computed tomography (CT) findings, he was diagnosed with high-grade hepatic injury with coeliac axis stenosis (CAS) due to compression by the median arcuate ligament, and an aberrant right hepatic artery. Read More

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Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.

PLoS Negl Trop Dis 2021 Jun 23;15(6):e0009554. Epub 2021 Jun 23.

Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.

Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. Read More

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Bile pulmonary embolism-related sudden death following an abdominal firearm injury: An autopsy case report and review of literature.

Forensic Sci Med Pathol 2021 Jun 23. Epub 2021 Jun 23.

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Bile pulmonary embolism (BPE) is a rare type of non-thrombotic pulmonary embolism (NTPE). For bile emboli to pass through the bloodstream to the lungs, there must be a connection created between the biliary and the venous vessels. This article reports a fatal BPE in a 12-year-old child who died 14 days following an abdominal firearm injury. Read More

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Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers.

Clin Exp Pharmacol Physiol 2021 Jun 22. Epub 2021 Jun 22.

Departments of Physiology Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.

Cholestasis caused by slowing or blockage of bile flow is a serious liver disease that can lead to liver fibrosis and cirrhosis. The link between transforming growth factor beta 1 (TGFβ1), Smad family member 3 (Smad3), and microRNA 21 (miR21) in bile duct ligation (BDL)-induced liver fibrosis in the presence and absence of the anti-inflammatory and antioxidant compound, resveratrol (RSV) has not been previously studied. Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. Read More

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Depacked patients who underwent a shortened perihepatic packing for severe blunt liver trauma have a high survival rate: 20 years of experience in a level I trauma center.

Surgeon 2021 Jun 18. Epub 2021 Jun 18.

Department of Digestive and Endocrine Surgery, Pitié Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Sorbonne Université, Paris, France. Electronic address:

Introduction: Non-operative management is currently the preferred approach in blunt liver trauma, including high grade liver lesions. However, hemodynamic instability imposes the need for an emergency laparotomy, with a perihepatic packing (PHP) to control liver bleeding in most cases. Our retrospective study aimed to assess the outcomes of liver trauma patients who underwent a shortened PHP. Read More

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Cardiac-induced liver deformation as a measure of liver stiffness using dynamic imaging without magnetization tagging-preclinical proof-of-concept, clinical translation, reproducibility and feasibility in patients with cirrhosis.

Abdom Radiol (NY) 2021 Jun 20. Epub 2021 Jun 20.

Division of Medicine, Centre for Medical Imaging, University College London (UCL), London, UK.

Purpose: MR elastography and magnetization-tagging use liver stiffness (LS) measurements to diagnose fibrosis but require physical drivers, specialist sequences and post-processing. Here we evaluate non-rigid registration of dynamic two-dimensional cine MRI images to measure cardiac-induced liver deformation (LD) as a measure of LS by (i) assessing preclinical proof-of-concept, (ii) clinical reproducibility and inter-reader variability, (iii) the effects of hepatic hemodynamic changes and (iv) feasibility in patients with cirrhosis.

Methods: Sprague-Dawley rats (n = 21 bile duct ligated (BDL), n = 17 sham-operated controls) and fasted patients with liver cirrhosis (n = 11) and healthy volunteers (HVs, n = 10) underwent spoiled gradient-echo short-axis cardiac cine MRI studies at 9. Read More

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Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms.

Life Sci 2021 Jun 17:119730. Epub 2021 Jun 17.

Department of Chemistry, Faculty of Science and Literature, 12000-Bingol University, Bingol, Turkey.

Aim: High dose of fluoride intake is associated with toxic effects on liver and kidney tissues. One approach to tackle these toxicities is using natural antioxidants as supplements. This study evaluated the ameliorative effects of hesperidin (HSP) against sodium fluoride (NaF)-induced hepatotoxicity and nephrotoxicity in wistar albino rats. Read More

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Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability.

J Sci Food Agric 2021 Jun 18. Epub 2021 Jun 18.

Department of Biology, College of Science, United Arab Emirates University, 15551, Al-Ain, United Arab Emirates.

Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as an aromatic stimulant, a food preservative, and coloring material. The commonly used names of turmeric are castor saffron, turmeric, and saffron root. Read More

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Pedunculated hepatic focal nodular hyperplasia: A case report and review of the literature.

Clin Case Rep 2021 Jun 9;9(6):e04202. Epub 2021 Jun 9.

Department of General Surgery Trauma Center Ben Arous University of Tunis El Manar Tunis Tunisia.

Focal nodular hyperplasia (FNH) is a common asymptomatic benign hepatic tumor encountered in middle-aged women. However, pedunculated FNH is exceedingly rare and more frequently associated with complications. That is why surgical management is mandatory in this form. Read More

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ROTEM Testing for Direct Oral Anticoagulants.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.

Direct oral anticoagulants (DOACs) are increasingly used worldwide for the prevention of stroke in patients with atrial fibrillation and to prevent or treat venous thromboembolism. In situations such as serious bleeding, the need for urgent surgery/intervention or the management of a thromboembolic event, the laboratory measurement of DOACs levels or anticoagulant activity may be required. Rotational thromboelastometry (ROTEM) is a viscoelastic hemostatic assay (VHA) which has been used in emergencies (trauma and obstetrics), and surgical procedures (cardiac surgery and liver transplants), but experience with this assay in DOACs-treated patients is still limited. Read More

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Management of factor XI deficiency in oncological liver and colorectal surgery by therapeutic plasma exchange: A case report.

Transfus Apher Sci 2021 May 31:103176. Epub 2021 May 31.

Transfusion Medicine Deparment, Hospital Italiano de Buenos Aires, Argentina.

Introduction: Factor XI (FXI) deficiency is a rare congenital hemostatic disorder associated with increased bleeding tendency in trauma, surgery or when other hemostatic defects are present. Perioperative hemostatic management of a patient with a severe FXI deficiency undergoing major oncological liver and colorectal surgery with therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) is reported.

Case Description: A 54-year-old male with severe FXI deficiency was scheduled for resection of synchronous rectal cancer and multiple liver metastases. Read More

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The 6-week Effects of HIIT on Biomarkers of Tissue and Oxidative Damage in Wistar Rats Previously Supplemented with Pyridoxine.

Int J Exerc Sci 2021 1;14(7):369-381. Epub 2021 Apr 1.

Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, Sergipe, BRAZIL.

We aimed to analyze the effects of long high-intensity interval training (HIIT) associated with pyridoxin supplementation on tissue and oxidative injury markers in animals. Male Wistar rats were divided into three groups (n = 8): sedentary (GS), HIIT (GH), and HIIT + pyridoxine (GHP). The HIIT comprised 18 sessions of 7 repetitions of 2min × 2min rest, 3 times per week. Read More

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Vinpocetine-based therapy is an attractive strategy against oxidative stress-induced hepatotoxicity in vitro by targeting Nrf2/HO-1 pathway.

EXCLI J 2021 4;20:550-561. Epub 2021 Mar 4.

Department of Pharmacology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.

Vinpocetine (Vin), a synthetic-derivative of Vincamine, monoterpenoid indole alkaloid, has been reported to have various medicinal benefits. The purpose of our study was to investigate the pivotal role of "nuclear factor erythroid 2-related factor-2" (Nrf2)-mediated antioxidant protection of Vin against HO and paracetamol (APAP)-induced liver toxicity. For this purpose, a normal human hepatic cell line (L02 cells) was incubated with cytotoxic concentrations of HO or APAP in the presence or absence of Vin. Read More

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Anticoagulant-induced hemorrhagic cholecystitis with hemobilia after deceased donor kidney transplant and literature review.

Int J Surg Case Rep 2021 May 26;84:106027. Epub 2021 May 26.

Augusta University, Department of Surgery, United States of America. Electronic address:

Introduction And Importance: Hemobilia and hemorrhagic cholecystitis are uncommon causes of right upper quadrant abdominal pain. The development of intra-gallbladder and biliary bleeding has been primarily associated with abdominal trauma, malignancy, liver transplant, and iatrogenic injury to the biliary tree and vasculature. Spontaneous anticoagulant induced hemorrhagic cholecystitis and hemobilia are incredibly rare events and have only been documented by a handful of case reports. Read More

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Laparoscopic-Assisted Transgastric Endoscopic Retrograde Cholangiopancreatography With Placement of a Biliary Stent to Treat Traumatic Intrahepatic Bile Duct Disruption in a Patient With Roux-en-Y Gastric Bypass.

Am Surg 2021 Jun 11:31348211025756. Epub 2021 Jun 11.

Division of General and Trauma Surgery, Department of Surgery, 10848WakeMed Health and Hospitals, Raleigh, NC, USA.

Hepatic injuries are common following blunt trauma and while frequently managed expectantly, biliary injury as a result of the trauma requires a high index of suspicion, a focused workup, and likely interventional treatment. A 44-year-old female with a history of Roux-en-Y gastric bypass presented after a ground level fall and was initially discharged home but represented with worsening abdominal pain and elevated liver enzymes. She was found to have a segment 5/6 biliary injury requiring laparoscopic-assisted transgastric endoscopic retrograde cholangiopancreatography with common bile duct stent placement. Read More

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Delayed pneumocephalus induced by repeated percutaneous aspiration after spinal surgery: A case report and literature review.

Medicine (Baltimore) 2021 Jun;100(23):e26322

Department of Internal Medicine, People's Hospital of Xilin County, Baise, China.

Rationale: Severe tension pneumocephalus can lead to drowsiness, coma, and even brain hernia and death. The occurrence of delayed pneumocephalus after spinal surgery is rarely reported and often ignored. Herein, we report a case of delayed pneumocephalus after repeated percutaneous aspiration following spinal surgery. Read More

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Postoperative incision scars and cosmetic satisfaction of living liver donors.

Medicine (Baltimore) 2021 Jun;100(23):e26187

Department of General Surgery, Changhua Christian Hospital, Changhua.

Abstract: Cosmetic appearance is a major concern for living donors. However, little is known about the impact of a surgical scar on body image changes in living liver donors. The aim of this study was to identify potential factors that cause displeasing upper midline incision scar, and to evaluate the overall satisfaction regarding body image and scarring after living donor hepatectomy. Read More

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Transplant Hepatectomy With Portacaval Shunt and MARS Therapy for Perioperative Catastrophe: A Series of Four Liver Transplant Cases.

Transplant Direct 2021 Mar 18;7(3):e674. Epub 2021 Feb 18.

University of Maryland School of Medicine, Baltimore, MD.

Increased worldwide focus on maximal donor utilization and transplantation of patients once considered too ill to survive liver transplantation may increase the otherwise rare frequency of catastrophic graft failure. Although the deleterious effects of an acutely failing allograft have been established for decades, the optimal strategy in this patient population in the perioperative period remains ill-defined.

Methods: A retrospective review of all liver transplant recipients with perioperative failure leading to transplant hepatectomy between January 1, 2014 and June 30, 2017 was performed. Read More

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A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood-Brain Barrier Transport Properties.

Adv Sci (Weinh) 2021 06 24;8(11):e2004856. Epub 2021 Mar 24.

Faculty of Technical Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna, 1060, Austria.

Physiological-relevant in vitro tissue models with their promise of better predictability have the potential to improve drug screening outcomes in preclinical studies. Despite the advances of spheroid models in pharmaceutical screening applications, variations in spheroid size and consequential altered cell responses often lead to nonreproducible and unpredictable results. Here, a microfluidic multisize spheroid array is established and characterized using liver, lung, colon, and skin cells as well as a triple-culture model of the blood-brain barrier (BBB) to assess the effects of spheroid size on (a) anticancer drug toxicity and (b) compound penetration across an advanced BBB model. Read More

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PGC-1 Protects against Hepatic Ischemia Reperfusion Injury by Activating PPAR and PPAR and Regulating ROS Production.

Oxid Med Cell Longev 2021 19;2021:6677955. Epub 2021 May 19.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Peroxisome proliferator-activated receptors (PPARs) and have been shown to be protective in hepatic ischemia/reperfusion (I/R) injury. However, the precise role of PPAR coactivator-1 (PGC-1), which can coactivate both of these receptors, in hepatic I/R injury, remains largely unknown. This study was designed to test our hypothesis that PGC-1 is protective during hepatic I/R injury in vitro and in vivo. Read More

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Patient blood management in India - Review of current practices and feasibility of applying appropriate standard of care guidelines. A position paper by an interdisciplinary expert group.

J Anaesthesiol Clin Pharmacol 2021 Jan-Mar;37(1):3-13. Epub 2021 Apr 10.

Department of Obstetrics and Gynaecology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

In a developing country like India, with limited resources and access to healthcare facilities, dealing with massive hemorrhage is a major challenge. This challenge gets compounded by pre-existing anemia, hemostatic disorders, and logistic issues of timely transfer of such patients from peripheral hospitals to centers with adequate resources and management expertise. Despite the awareness amongst healthcare providers regarding management modalities of bleeding patients, no uniform Patient Blood Management (PBM) or perioperative bleeding management protocols have been implemented in India, yet. Read More

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Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes.

Int Immunopharmacol 2021 Jun 4;97:107823. Epub 2021 Jun 4.

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Mesenchymal stem cells (MSCs) are multipotent cells beneficial in regenerative medicine and tissue repair. The therapeutic potential of MSCs for inflammatory diseases and conditions is partly due to secreted exosomes. Exosomes are one group of extracellular vesicles with 50-150 nm in diameter. Read More

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The traditional uses, phytochemistry, and pharmacological properties of Paris L. (Liliaceae): A review.

J Ethnopharmacol 2021 Jun 5;278:114293. Epub 2021 Jun 5.

Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China. Electronic address:

Ethnopharmacological Relevance: Paris L. (Liliaceae) consisted of 33 species, of which the study focused on Paris polyphylla Smith, P. polyphylla var. Read More

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Significance of urinary liver-type fatty acid-binding protein in patients with normal renal function after undergoing intestinal urinary diversion: a preliminary study.

Clin Exp Nephrol 2021 Jun 7. Epub 2021 Jun 7.

Department of Urology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan.

Background: Liver-type fatty acid-binding protein (L-FABP) in urine is one of the early diagnostic biomarkers for acute and chronic kidney injuries. Although this protein is also identified in the intestine, there is no verified reference value for patients with intestinal urinary diversion (UD). The aim of the present study was to measure L-FABP values in such patients and compare them with the results for patients without UD. Read More

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Evaluation of the Hypoglycemic Activity of by Targeting Protein Tyrosine Phosphatase 1B.

Front Pharmacol 2021 14;12:661803. Epub 2021 May 14.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.

() Pers. is one of six wild edible mushrooms that are widely used by Asian and European countries for their nutritional value. The present study assessed the anti-diabetic potential of methanolic extract (100 mg/kg body weight) on streptozotocin (STZ)-induced diabetic mice. Read More

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COVID-19 in normal, diseased and transplanted liver.

World J Gastroenterol 2021 May;27(20):2576-2585

Hepatology Unit, Department of Medicine, University of Tor Vergata, Rome 00133, Italy.

Starting from December 2019 the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has extended in the entire world giving origin to a pandemic. Although the respiratory system is the main apparatus involved by the infection, several other organs may suffer coronavirus disease 2019 (COVID-19)-related injuries. The human tissues expressing angiotensin-converting enzyme 2 (ACE2) are all possible targets of viral damage. Read More

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The implementation of a pathway and care bundle for the management of acute occlusive arterial mesenteric ischemia reduced mortality.

J Trauma Acute Care Surg 2021 Jun 4. Epub 2021 Jun 4.

HUS Abdominal Center, Abdominal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland HUS Abdominal Center, Vascular Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland HUS Medical Imaging Center, Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland HUS Abdominal Center, Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Acute mesenteric ischemia (AMI) is a disease with high mortality and requires a multidisciplinary approach for effective management. A pathway and care bundle were developed and implemented with the objective to reduce mortality. The aim of this retrospective comparative study was to analyze the effects of the pathway on patient management and outcome. Read More

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