26,295 results match your criteria Liver Trauma


The shock index, pediatric age-adjusted (SIPA) enhanced: Prehospital and emergency department SIPA values forecast transfusion needs for blunt solid organ injured children.

Surgery 2020 Jul 10. Epub 2020 Jul 10.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO; Department of Surgery, University of Colorado School of Medicine, Aurora, CO; Department of Surgery, Denver Health Medical Center, CO.

Background: The elevated shock index, pediatric age-adjusted (SIPA) has been found to accurately predict the need for blood transfusion in severely injured children. We sought to determine the utility of monitoring sequential SIPA values from the prehospital setting through the emergency department to identify children with a blunt liver or spleen injury who will require a blood transfusion.

Methods: We conducted a retrospective review of children 1 to 18 years old admitted to a level-1 pediatric trauma center with any grade blunt liver or spleen injury between 2009 and 2019. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.061DOI Listing

Sea Buckthorn and Grape Antioxidant Effects in Hyperlipidemic Rats: Relationship with the Atorvastatin Therapy.

Evid Based Complement Alternat Med 2020 22;2020:1736803. Epub 2020 Jun 22.

Banat University of Agriculture and Veterinary Medicine "King Michael I of Romania" from Timisoara, 119 Calea Aradului, Timisoara 300645, Romania.

Background: Medications to reduce oxidative stress are preventing cellular damage associated with hyperlipidemia. In this regard, statins (e.g. Read More

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http://dx.doi.org/10.1155/2020/1736803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327606PMC

[Early efficacy of islet transplantation in the treatment of adult advanced diabetes].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(26):2040-2043

Organ Transplantation Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

To evaluate the safety and efficacy of islet transplantation for patients with advanced diabetes. Five cases of islet allotransplantation were performed on 4 adult recipients. The same blood type adult brain-dead pancreas donors were selected and the islets were prepared in GMP laboratory. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191012-02204DOI Listing

Increasing age is associated with worse outcomes in elderly patients with severe liver injury.

Am J Surg 2020 Jul 2. Epub 2020 Jul 2.

New York University School of Medicine, Department of Surgery, NYC Health & Hospitals/Bellevue, New York, USA. Electronic address:

While the incidence of geriatric trauma continues to increase, outcomes following severe blunt liver injury (BLI) are unknown. We sought to investigate independent predictors of mortality among elderly trauma patients with severe BLI. A retrospective study of the NTDB (2014-15) identified patients with isolated, high-grade BLI. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.06.060DOI Listing

Liver resection in Cirrhotic liver: Are there any limits?

Int J Surg 2020 Jul 9. Epub 2020 Jul 9.

Chairman of HPB Surgical Division. Miguel Servet University Hospital. Zaragoza, Spain.

Liver resection remains one of the most technically challenging surgical procedure in abdominal surgery due to the complex anatomical arrangement in the liver and its rich blood supply that constitutes about 20% of the cardiac output per cycle. The challenge for resection in cirrhotic livers is even higher because of the impact of surgical stress and trauma imposed on borderline liver function and the impaired ability for liver regeneration in cirrhotic livers. Nonetheless, evolution and advancement in surgical techniques as well as knowledge in perioperative management of liver resection has led to a substantial improvement in surgical outcome in recent decade. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.050DOI Listing

Role of B Cell Lymphoma 2 in the Regulation of Liver Fibrosis in miR-122 Knockout Mice.

Biology (Basel) 2020 Jul 8;9(7). Epub 2020 Jul 8.

Department of Pathology, The Ohio State University, Columbus, OH 43210, USA.

MicroRNA-122 (miR-122) has been identified as a marker of various liver injuries, including hepatitis- virus-infection-, alcoholic-, and non-alcoholic steatohepatitis (NASH)-induced liver fibrosis. Here, we report that the extracellular miR-122 from hepatic cells can be delivered to hepatic stellate cells (HSCs) to modulate their proliferation and gene expression. Our published Argonaute crosslinking immunoprecipitation (Ago-CLIP) data identified several pro-fibrotic genes, including Ctgf, as miR-122 targets in mice livers. Read More

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http://dx.doi.org/10.3390/biology9070157DOI Listing

Evaluating toxicity impacts of environmental exposed chromium on small Indian mongoose (Urva auropunctatus) hematological, biochemical and histopathological functioning.

Chemosphere 2020 Jul 1;259:127485. Epub 2020 Jul 1.

Faculty of Information Technology, University of Information Technology and Management, Rzeszow, Poland.

Sub-lethal toxic impacts of chromium on hematological, biochemical and histological parameters were analyzed in the female small Indian mongoose (Urva auropuctatus) residing contaminated environment of tannery industry. Chromium bioaccumulation in the blood, liver and kidney tissue of the exposed mongooses was found elevated compared to the control mongooses' tissues. Total body weight (75. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127485DOI Listing

MiR-451a ameliorates alcoholic hepatitis via repressing HDAC8-mediated proinflammatory response.

Kaohsiung J Med Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Physiology, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.

Alcoholic hepatitis (AH) is identified as an inflammatory syndrome with high morbidity and mortality as a result of severe hepatocellular dysfunction and liver injury. Accumulated studies indicated that miRNAs are involved in AH. The potential effect of miR-451a in AH mice was examined in the current study. Read More

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http://dx.doi.org/10.1002/kjm2.12272DOI Listing

Gadolinium-hyaluronic acid nanoparticles as an efficient and safe magnetic resonance imaging contrast agent for articular cartilage injury detection.

Bioact Mater 2020 Dec 21;5(4):758-767. Epub 2020 Jun 21.

Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Accurate detection of cartilage injuries is critical for their proper treatment because these injuries lack the self-healing ability and lead to joint dysfunction. However, the low longitudinal T1 relaxivity (1) and non-specificity of contrast agents (such as gadolinium(III)-diethylenetriamine-pentaacetic acid (Gd-DTPA)) significantly limit the efficiency of clinical magnetic resonance imaging (MRI) applications. To overcome these drawbacks, we integrated hyaluronic acid (HA) with Gd to synthesize a Gd-DTPA-HA composite, which was subsequently freeze-dried to produce nanoparticles (NPs). Read More

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http://dx.doi.org/10.1016/j.bioactmat.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317168PMC
December 2020

[Progress of research on effect and mechanism of Scutellariae Radix on preventing liver diseases].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2808-2816

Jiangxi Key Laboratory of Natural Drug Research, College of Chemistry and Bioengineering,Yichun University Yichun 336000, China.

Scutellariae Radix is a kind of traditional Chinese medicine, which has the functions of heat-clearing and damp-drying, purging fire and detoxifying, hemostasis and miscarriage prevention. Modern pharmacological studies show that Scutellariae Radix has various effects, such as anti-oxidation, anti-inflammatory, liver protection and antiviral microorganisms. By searching the documents in the past ten years, the author has found that Scutellariae Radix and its active components play an important role in protecting the liver. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200224.403DOI Listing

Does vascular occlusion in liver resections predispose to recurrence of malignancy in the liver remnant due to ischemia/reperfusion injury? A comparative retrospective cohort study.

Int J Surg 2020 Jun 30;80:68-73. Epub 2020 Jun 30.

4th Department of Surgery, School of Medicine, National and Kapodistrian University of Athens, "Attikon" Hospital, Athens, Greece.

Background: Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.

Methods: One hundred and eighteen patients were subjected to liver resection under total inflow and outflow vascular clamping and were assigned as study group. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.019DOI Listing

Systematic Review of the Management of Retro-Hepatic Inferior Vena Cava Injuries.

Open Access Emerg Med 2020 26;12:163-171. Epub 2020 Jun 26.

Brighton and Sussex University Hospitals, Brighton, UK.

Background: Retro-hepatic inferior vena cava (RHIVC) injuries resulting from blunt or penetrating abdominal trauma are rare but devastating events that remain a considerable challenge to even the most experienced doctors, which continue to carry a considerable mortality.

Aim: To establish a better understanding of the management of RHIVC injuries and to identify any adjuncts or operative methods that were associated with an increased survival.

Methods: A systematic review of the MEDLINE database was conducted using Medical Search Headings and exploded keywords and phrases. Read More

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http://dx.doi.org/10.2147/OAEM.S247380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326178PMC

Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries.

Eur J Clin Microbiol Infect Dis 2020 Jul 1. Epub 2020 Jul 1.

Institute of Clinical Pharmacology, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Anti-inflammatory and Immune Medicine Innovation Team, Anhui Medical University, No. 81 Meishan road, Shushan District, Hefei, 230032, Anhui Province, China.

This study compared the laboratory indexes in 40 non-severe COVID-19 patients with those in 57 healthy controls. In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating hormone, growth hormone, and insulin-like growth factor-binding protein 3 significantly decreased, and total protein, albumin, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase, activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer, fibrinogen degradation products, human epididymal protein 4, serum ferritin, and C-reactive protein were elevated. SARS-CoV-2 infection can affect hematopoiesis, hemostasis, coagulation, fibrinolysis, bone metabolism, thyroid, parathyroid glands, the liver, and the reproductive system. Read More

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http://dx.doi.org/10.1007/s10096-020-03967-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329266PMC

Significance of body temperature in elderly patients with sepsis.

Crit Care 2020 Jun 30;24(1):387. Epub 2020 Jun 30.

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in elderly and non-elderly patients with sepsis.

Methods: This was a retrospective observational study. Read More

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http://dx.doi.org/10.1186/s13054-020-02976-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329464PMC

Osseointegration of titanium implants with a novel silver coating under dynamic loading.

Eur Cell Mater 2020 Jun 30;39:249-259. Epub 2020 Jun 30.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm,

Postoperative implant-associated infections are a severe complication in orthopaedics and trauma surgery. To address this problem, a novel implant coating was recently developed, which allows for the release of low concentrations of bactericidal silver. For an intended use on load-bearing endoprostheses, stable bone integration is required. Read More

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http://dx.doi.org/10.22203/eCM.v039a16DOI Listing

Hydrogen: An Endogenous Regulator of Liver Homeostasis.

Front Pharmacol 2020 11;11:877. Epub 2020 Jun 11.

Department of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Basic and clinical studies have shown that hydrogen (H), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H due to lack of the expression of hydrogenase. The endogenous H in human body is mainly produced by anaerobic bacteria, such as and , in gut and other organs through the reversible oxidation reaction of 2 H + 2 e ⇌ H. Read More

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http://dx.doi.org/10.3389/fphar.2020.00877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301907PMC

Assessment of computed tomography indications and computed tomography reports for usefulness in clinical presentation at postoperative follow-up of gunshot wound cases.

Ulus Travma Acil Cerrahi Derg 2020 Jun;26(4):613-619

Deparmant of General Surgery, University of Health Sciences Gülhane Training and Research Hospital, Ankara-Turkey.

Background: The present study aimed to evaluate the results of lower thoracic tomography (LTT) and upper abdominal tomography (UAT) of the patients who were treated and followed at our tertiary center due to gunshot wounds (GSWs).

Methods: The present research was designed as a retrospective descriptive study. All patients, who were admitted to our clinic due to GSW between January 2016 and April 2020, were retrospectively analyzed. Read More

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http://dx.doi.org/10.14744/tjtes.2020.26862DOI Listing

Failed angioembolization of a ruptured liver hemangioma complicated by iatrogenic injury of subclavian vein during catheter insertion.

Ulus Travma Acil Cerrahi Derg 2020 Jun;26(4):635-638

Division of Trauma Surgery, Department of Surgery, Chonnam National University Hospital and Medical School, Gwangju-Korea.

In this study, we report a case of failed angioembolization of a ruptured liver hemangioma complicated by iatrogenic injury of the subclavian vein during catheter insertion. A 30-year-old woman experienced blunt trauma upon falling from her bed. Laceration of a seemingly preexisting hepatic hemangioma was diagnosed. Read More

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http://dx.doi.org/10.14744/tjtes.2019.04343DOI Listing

Left-sided portal hypertension caused by idiopathic splenic vein stenosis improved by splenectomy: a case report.

Surg Case Rep 2020 Jun 26;6(1):148. Epub 2020 Jun 26.

Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Splenic vein stenosis and occlusion, which are known causes of left-sided portal hypertension, often occur secondary to trauma, pancreatitis, or invasion or compression by pancreatic tumors. However, few reports have described idiopathic splenic vein stenosis.

Case Presentation: A 70-year-old man was referred to our hospital for examination of isolated gastric varices. Read More

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http://dx.doi.org/10.1186/s40792-020-00912-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316945PMC

Structural alterations and inflammation in the heart after multiple trauma followed by reamed versus non-reamed femoral nailing.

PLoS One 2020 25;15(6):e0235220. Epub 2020 Jun 25.

Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, Germany.

Background: Approximately 30,000 patients with blunt cardiac trauma are recorded each year in the United States. Blunt cardiac injuries after trauma are associated with a longer hospital stay and a poor overall outcome. Organ damage after trauma is linked to increased systemic release of pro-inflammatory cytokines and damage-associated molecular patterns. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235220PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316303PMC

Kidney Ischemia-Reperfusion Elicits Acute Liver Injury and Inflammatory Response.

Front Med (Lausanne) 2020 2;7:201. Epub 2020 Jun 2.

St. Boniface Hospital Research Centre, Winnipeg, MB, Canada.

Ischemia-reperfusion (IR) is a common risk factor that causes acute kidney injury (AKI). AKI is associated with dysfunction of other organs also known as distant organ injury. The liver function is often compromised in patients with AKI and in animal models. Read More

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http://dx.doi.org/10.3389/fmed.2020.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280447PMC

Pushing the limits in DCD donor selection: optimizing graft rehabilitation with ex vivo machine perfusion.

Liver Transpl 2020 Jun 23. Epub 2020 Jun 23.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.

Background: The use of liver grafts from donors after circulatory death (DCD) is associated with an increased risk of developing severe transplant-related complications. However, a balanced evaluation of risks calculated on both donor's and recipient's specific medical history, may reduce the incidence of post-operative complications avoiding a futile transplant.

Methods: We report a case wherein we transplanted a patient with hepatocellular carcinoma (HCC) outside Milan criteria using a borderline DCD graft. Read More

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http://dx.doi.org/10.1002/lt.25833DOI Listing

Disturbing medical findings in war-related traumatic amputation patients: a clinical descriptive study from Gaza.

BMJ Open 2020 Jun 22;10(6):e034648. Epub 2020 Jun 22.

The Anaesthesia and Critical Care Research Group, Institute of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway.

Objectives: The aim of this study was to explore possible long-term negative health effects of injuries sustained by modern weaponry.

Setting: The study was conducted in Gaza's main hospital, Al-Shifa Hospital.

Participants: During the last 10 to 15 years, thousands of civilian Palestinians in Gaza have survived numerous military incursions, but with war-related traumatic injuries caused by explosive weapons. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311037PMC

Glucocorticoid versus traditional therapy for hepatitis B virus-related acute-on-chronic liver failure: A systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(25):e20604

Infectious Disease Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

Objective: This meta-analysis aimed to assess the efficacy and safety of glucocorticoid versus traditional therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF).

Methods: PubMed, Cochrane Central Register of Clinical Trials, and EMBASE were searched. All clinical studies, including randomized controlled studies and cohort studies, comparing glucocorticoids with traditional treatments (until November 1, 2018), were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000020604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310991PMC
June 2020
5.723 Impact Factor

No news is good news? Three-year postdischarge mortality of octogenarian and nonagenarian patients following emergency general surgery.

J Trauma Acute Care Surg 2020 Jul;89(1):230-237

From the Division of Trauma, Emergency Surgery, and Surgical Critical Care (N.N., J.H., M.K., J.M.L., N.K., G.V., D.K., P.F., N.S., A.M., M.R., H.M.A.K.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Surgery (N.N.), and Department of Anesthesiology (M.K.), Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand; and Center for Outcomes and Patient Safety in Surgery (H.M.A.K.), Massachusetts General Hospital, Boston, Massachusetts.

Background: Outcome data on the very elderly patients undergoing emergency general surgery (EGS) are sparse. We sought to examine short- and long-term mortality in the 80 plus years population following EGS.

Methods: Using our institutional 2008-2018 EGS Database, all the 80 plus years patients undergoing EGS were identified. Read More

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http://dx.doi.org/10.1097/TA.0000000000002696DOI Listing

Regression of liver fibrosis: evidence and challenges.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing 100050, China.

It has been reported that liver fibrosis could be reversed after eliminating liver injuries. This article systematically summarizes the evidence of fibrosis regression based on histology, liver stiffness, and serum biomarkers, and discusses several clinically relevant challenges. Evidence from liver biopsy has been regarded as the gold standard in the assessment of fibrosis regression. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000835DOI Listing

The compelling arguments for the need of microvascular investigation in COVID-19 critical patients.

Authors:
Romeo Martini

Clin Hemorheol Microcirc 2020 Jun 19. Epub 2020 Jun 19.

Unità Operativa di Angiologia, Azienda Ospedaliera Universitaria di Padova, Padova, Italy.

The burden of pandemic COVID-19 is growing worldwide, as the continuous increases of contagion. Only 10-15% of the entire infected population has the necessity of intensive care unit (ICU) treatments. But, this relatively low rate of patients has absorbed almost the whole availability of ICU during few days, becoming at least in Italy, an emergency for the national health system. Read More

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http://dx.doi.org/10.3233/CH-200895DOI Listing

Cytoreduction surgery and hyperthermic intraperitoneal chemotherapy for treating advanced peritoneal metastases of hepatocellular carcinoma.

Pleura Peritoneum 2020 Jun 15;5(2):20190030. Epub 2020 May 15.

Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: An effective treatment strategy for peritoneal metastasis (PM) of hepatocellular carcinoma (HCC-PM) has yet to be established. Although cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown favorable outcomes in certain malignancies, their role in peritoneal metastatic HCC is unclear. Herein, we present a series of patients with HCC-PM treated with CRS/HIPEC and evaluate their outcomes. Read More

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http://dx.doi.org/10.1515/pp-2019-0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292233PMC

Inhibition of eIF2 Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury.

Biomed Res Int 2020 5;2020:2626090. Epub 2020 Jun 5.

Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563003 Guizhou, China.

Objectives: Protein kinase R-like ER kinase (PERK)/eukaryotic initiation factor 2 alpha (eIF2) is an important factor along the main pathways for endoplasmic reticulum (ER) stress-mediated apoptosis. In this study, we investigated the effects of eIF2 phosphorylation on hepatocyte apoptosis and the ER stress mechanisms in acute liver injury.

Methods: eIF2 phosphorylation and apoptosis under ER stress were monitored and measured in male BALB/c mice with acute liver injury and human hepatocyte line LO2 cells. Read More

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http://dx.doi.org/10.1155/2020/2626090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293739PMC

Laparoscopic Resection of a Left Upper Quadrant Mass Leading to a Surprise Diagnosis.

Case Rep Surg 2020 30;2020:8365061. Epub 2020 May 30.

University of Maryland Community Medical Group, Easton, MD, USA.

. Resplenectomy is most commonly done for the treatment of recurrent idiopathic thrombocytopenic purpura (ITP) refractory to medical management due to the regrowth of a missed accessory spleen. . Read More

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http://dx.doi.org/10.1155/2020/8365061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284930PMC

Bicycle handlebar injury in a child resulting in complex liver laceration with massive bleeding and bile leakage: A case report.

Int J Surg Case Rep 2020 Jun 12;72:386-390. Epub 2020 Jun 12.

Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloska 7, 1000, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.

Introduction: Bicycle accidents are a significant cause of traumatic morbidity in the paediatric population. The handlebar injuries are usually isolated and remain a major source of bicycle related morbidity. We present a case of severe liver laceration with left hepatic duct transection caused by handlebar trauma in a 13-year-old boy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306525PMC

Neuropraxia: An Underappreciated Morbidity of Liver Transplantation.

J Surg Res 2020 Jun 18;255:188-194. Epub 2020 Jun 18.

Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Division of Transplantation, Department of Surgery, Northwestern Medicine, Chicago, Illinois. Electronic address:

Background: Peripheral nerve injuries can be devastating complications of surgery, potentially resulting in severe functional disability and decreased quality of life. Long surgeries with considerable tissue manipulation, for example, liver transplantation, may present increased risk; however, neuropraxia in transplantation has not been well investigated.

Materials And Methods: This is a retrospective study of all adult patients undergoing liver transplantation at a large academic center between January 2013 and December 2015. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.030DOI Listing

Acute pancreatic injuries: A complication of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with cytotoxic immune cell activation.

J Am Acad Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Electronic address:

Background: Complications involving internal organs are usually present in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, pancreatic complications are rarely reported and studied.

Objective: To summarize clinical characteristics of SJS/TEN-associated acute pancreatic injuries (API) and to investigate underlying inflammatory mechanisms. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297678PMC

Unraveling the mystery of Covid-19 cytokine storm: From skin to organ systems.

Dermatol Ther 2020 Jun 19:e13859. Epub 2020 Jun 19.

Department of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

COVID-19 is a global pandemic that emerged from Wuhan, China. Besides pneumonia and acute respiratory distress syndrome, the disease leads to multisystem involvement in the form of myocarditis, arrhythmias, cardiac arrest, gastrointestinal symptoms, hypoxemic brain injury, acute liver, and renal function impairment. There are also reports of cutaneous lesions in form of urticarial and maculopapular rashes, chilblain like fingers and toes (covid feet), livedoid vasculopathy, and chicken-pox like or varicelliform vesicles. Read More

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http://dx.doi.org/10.1111/dth.13859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323083PMC

Regenerative potential of Wharton's jelly-derived mesenchymal stem cells: A new horizon of stem cell therapy.

J Cell Physiol 2020 Jun 18. Epub 2020 Jun 18.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Umbilical cord Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have recently gained considerable attention in the field of regenerative medicine. Their high proliferation rate, differentiation ability into various cell lineages, easy collection procedure, immuno-privileged status, nontumorigenic properties along with minor ethical issues make them an ideal approach for tissue repair. Besides, the number of WJ-MSCs in the umbilical cord samples is high as compared to other sources. Read More

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http://dx.doi.org/10.1002/jcp.29810DOI Listing

Main gut bacterial composition differs between patients with type 1 and type 2 diabetes and non-diabetic adults.

J Diabetes Metab Disord 2020 Jun 8;19(1):265-271. Epub 2020 Feb 8.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Regarding the role of gut microbial dysbiosis in hyperglycemia, we aimed to compare the main gut bacterial composition among type 1 and type 2 diabetic patients and healthy non-diabetic adults.

Methods: A total of 110 adult subjects (49 patients diagnosed with type 2 diabetes, 21 patients diagnosed with type 1 diabetes and 40 healthy persons) were included in this case-control study. The intestinal microbiota composition was investigated by quantitative real-time polymerase chain reaction (qPCR) method targeting bacterial 16S rRNA gene. Read More

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http://dx.doi.org/10.1007/s40200-020-00502-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270240PMC

Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model.

Stem Cell Res Ther 2020 Jun 16;11(1):237. Epub 2020 Jun 16.

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, People's Republic of China.

Background: Although it has been preclinically suggested that adipose tissue-derived mesenchymal stem cell (ADSC)-based therapy could effectively treat chronic liver diseases, the hepatic engraftment of ADSCs is still extremely low, which severely limits their long-term efficacy for chronic liver diseases. This study was designed to investigate the impact of antioxidant preconditioning on hepatic engraftment efficiency and therapeutic outcomes of ADSC transplantation in liver fibrotic mice.

Methods: Liver fibrosis model was established by using intraperitoneal injection of carbon tetrachloride (CCl) in the male C57BL/6 mice. Read More

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http://dx.doi.org/10.1186/s13287-020-01763-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298967PMC

Case report: Evisceration of abdomen after blunt trauma.

Int J Surg Case Rep 2020 Jun 1;72:207-211. Epub 2020 Jun 1.

King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Department of Surgery, Saudi Arabia.

Introduction: Abdominal evisceration is uncommon after blunt abdominal trauma; therefore, it warrants urgent laparotomy. We report a young adult male who sustained multiple injuries due to a high impact mechanism resulting in blunt abdominal injury and underwent numerous laparotomies.

Case Report: In a high-speed motorcycle accident, a twenty-six-year-old male sustained a direct, blunt injury to his abdomen, which resulted in a right hemothorax, perforation of the stomach, and small bowel. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298532PMC

The importance of wearing a seatbelt correctly - A case report of blunt trauma causing complete shearing transection of the gastroduodenal junction.

Int J Surg Case Rep 2020 May 19;72:197-201. Epub 2020 May 19.

The Royal Adelaide Hospital, Port Road, Adelaide, South Australia, 5000, Australia.

Introduction: Global mortality as a result of road traffic accidents (RTA) has reduced significantly since mandatory implementation of seatbelts. Whilst seatbelt related injury, or "seatbelt syndrome," is a recognised phenomenon, unrestrained passengers have considerably worse survival outcomes. Improper positioning of seatbelts, as is discussed in the following case, can cause extensive injury. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298554PMC

Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site.

Emerg Microbes Infect 2020 Dec;9(1):1474-1488

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

The mutations in the SARS-CoV-2 virus genome during COVID-19 dissemination are unclear. In 788 COVID-19 patients from Zhejiang province, we observed decreased rate of severe/critical cases compared with patients in Wuhan. For mechanisms exploration, we isolated one strain of SARS-CoV-2 (ZJ01) from a mild COVID-19 patient. Read More

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http://dx.doi.org/10.1080/22221751.2020.1781551DOI Listing
December 2020

Massive liver haemangioma causing Kasabach-Merritt syndrome in an adult.

Ann R Coll Surg Engl 2020 Jun 15:e1-e4. Epub 2020 Jun 15.

Mount Lebanon Hospital, Mount Lebanon, Lebanon.

Liver haemangiomas are common, but their size very rarely exceeds 40cm. Most people with liver haemangiomas are asymptomatic, and diagnosis is usually made incidentally during imaging for other complaints. When a liver haemangioma is symptomatic or produces complications, surgical intervention may be warranted. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0146DOI Listing
June 2020
1.223 Impact Factor

[Investigation of 603 medical staff occupational exposure with blood-borne pathogens].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 May;38(5):349-352

The First Affiliated Hospital of Kunming Medical University, The NHC Key Laboratory of Drug Addiction Medicine and Department of Infectious Disease, Kunming 650032, China.

To investigate the occupational exposure with blood-borne pathogens of medical staff, and explore the protective strategy. Using cluster sampling method, 603 medical staff with occupational exposure with blood-borne pathogens were analyzed, from July 2014 to July 2018 in a tertiary hospital. In total of 603 occupational exposure incidents, 70. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20190510-00191DOI Listing

Lethal recreational activities involving horses - A Forensic study.

Authors:
Roger W Byard

Leg Med (Tokyo) 2020 Sep 6;46:101728. Epub 2020 Jun 6.

School of Medicine, The University of Adelaide, Frome Road, Adelaide, South Australia, 5005, Australia. Electronic address:

A search was undertaken of the Forensic Science South Australia, Australia, autopsy database over a 25-year period from 1995 to 2019 with the aim of understanding more about the role that recreational horse use not involving racing may have in mortality. Eight cases were found with an age range of 8-73 years (mean 47 years) and a male:female ratio of 5:3. The major category was a fall while riding (N = 7) with the remaining case (N = 1) sustaining a lethal kicking. Read More

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http://dx.doi.org/10.1016/j.legalmed.2020.101728DOI Listing
September 2020

An Uncommon Focal Liver Lesion: Intrahepatic Splenosis.

J Gastrointestin Liver Dis 2020 Jun 3;29(2):257-262. Epub 2020 Jun 3.

Unit of Internal Medicine, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola- Malpighi, Bologna.

Multiple focal liver lesions were incidentally detected in a patient screened by ultrasound for a recent diagnosis of lower limb deep vein thrombosis, for which anticoagulation had been initiated. Past medical history reported a post-traumatic splenectomy 15 years before. Magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) showed a subcapsular lesion in liver segment 5 consistent with focal nodular hyperplasia (FNH) and multiple other nodules, with a different pattern from the former, judged as probable hepatic adenomas by MRI but probable hemangiomas by CEUS (hyperenhancement in the late phase). Read More

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http://dx.doi.org/10.15403/jgld-617DOI Listing

-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice.

Int J Mol Sci 2020 Jun 9;21(11). Epub 2020 Jun 9.

Laboratory of Surgical Physiopathology-LIM-08, Department of Surgery, Faculdade de Medicina da Universidade de São Paulo (FMUSP), 01246-903 São Paulo, SP, Brazil.

-acetylcysteine (NAC) is a pharmacological alternative with great potential for reducing the deleterious effects of surgical procedures on patients with steatohepatitis. We evaluated the effect of NAC on hepatic ischemia/reperfusion (I/R) injury in C57BL/6J mice, 8 weeks-old, weighing 25-30 g, with steatohepatitis induced by a methionine- and choline-deficient (MCD) diet. Groups: MCD group (steatohepatitis), MCD-I/R group (steatohepatitis plus 30 min of 70% liver ischemia and 24 h of reperfusion), MCD-I/R+NAC group (same as MCD-I/R group plus 150 mg/kg NAC 15 min before ischemia), and control group (normal AIN-93M diet). Read More

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http://dx.doi.org/10.3390/ijms21114106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313069PMC

Attenuation of arsenic induced high fat diet exacerbated oxidative stress mediated hepatic and cardiac injuries in male Wistar rats by piperine involved antioxidative mechanisms.

Food Chem Toxicol 2020 Jun 7;142:111477. Epub 2020 Jun 7.

Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, 92, APC Road, Kolkata, 700009, India. Electronic address:

The current study explored the efficacy of piperine in attenuating arsenic induced high fat diet aggravated oxidative stress mediated injury in hepatic and cardiac tissues of male Wistar rats. Oral administration of piperine significantly (p < 0.05) reduced the levels of organ specific and oxidative stress biomarkers in arsenic and high fat diet treated rat hepatic and cardiac tissues in a dose dependant manner with the dose of 60 mg/kg b. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111477DOI Listing

differentiation of rhesus macaque bone marrow- and adipose tissue-derived MSCs into hepatocyte-like cells.

Exp Ther Med 2020 Jul 22;20(1):251-260. Epub 2020 Apr 22.

School of Medicine, Yunnan University, Kunming, Yunnan 650091, P.R. China.

Orthotopic liver or hepatocyte transplantation is effective for the treatment of acute liver injury and end-stage chronic liver disease. However, both of these therapies are hampered by the extreme shortage of organ donors. The clinical application of cell therapy through the substitution of hepatocytes with mesenchymal stem cells (MSCs) that have been differentiated into hepatocyte-like cells (HLCs) for liver disease treatment is expected to overcome this shortage. Read More

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http://dx.doi.org/10.3892/etm.2020.8676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273898PMC

Risk of hepatocellular carcinoma in Danish outpatients with alcohol-related cirrhosis.

J Hepatol 2020 Jun 5. Epub 2020 Jun 5.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Background And Aims: Accurate estimates of the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis are important for clinical decisions about HCC surveillance. We described HCC risk among outpatients with alcoholic cirrhosis and contrasted the risk of death from HCC with the risk of death from variceal bleeding or trauma.

Methods: This was a nationwide, registry-based historical cohort study between 2006 and 2018. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.05.043DOI Listing