35,270 results match your criteria Liver Transplantation Complications


Allograft fibrosis after paediatric liver transplantation: incidence, risk factors and evolution.

Liver Transpl 2021 Jun 23. Epub 2021 Jun 23.

Department of Pathology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Introduction: Allograft fibrosis(AF) after paediatric liver transplantation(pLT) is frequent, but its dynamics are unclear. Our aim was to assess the evolution and risk factors of AF after pLT.

Methods: A retrospective single-centre analysis of pLT with a follow-up ≥5 years, undergoing protocol liver biopsy at 6 months-1-2-5-10 years, was performed. Read More

View Article and Full-Text PDF

Cumulative damage effect of jaundice may be an effective predictor of complications in patients undergoing radical resection of Bismuth type II or above hilar cholangiocarcinoma.

Ann Transl Med 2021 May;9(10):861

Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.

Background: There is currently no preoperative risk assessment system for predicting complications after radical resection of hilar cholangiocarcinoma. This study examined the association between the cumulative damage effect of jaundice (CDEJ) and the complications of radical resection of Bismuth II or above hilar cholangiocarcinoma.

Methods: Patients who underwent radical resection of hilar cholangiocarcinoma at the Department of Hepatobiliary Surgery, West China Hospital of Sichuan University, from April 2010 to January 2018 were retrospectively included. Read More

View Article and Full-Text PDF

Perioperative and short-term oncological outcomes following laparoscopic versus open pancreaticoduodenectomy after learning curve in the past 10 years: a systematic review and meta-analysis.

Gland Surg 2021 May;10(5):1655-1668

Department of Liver Surgery and Liver Transplantation Centre, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Background: To compare perioperative and short-term oncologic outcomes of laparoscopic pancreaticoduodenectomy (LPD) to open pancreaticoduodenectomy (OPD) using data from large-scale retrospective cohorts and randomized controlled trials (RCTs) in the last 10 years.

Methods: A meta-analysis to assess the safety and feasibility of LDP and OPD registered with PROSPERO: (CRD42020218080) was performed according to the PRISMA guidelines. Studies comparing LPD with OPD published between January 2010 and October 2020 were included; only clinical studies reporting more than 30 cases for each operation were included. Read More

View Article and Full-Text PDF

Impact of Postoperative Complications on Long-Term Survival After Resection of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

Ann Surg Oncol 2021 Jun 23. Epub 2021 Jun 23.

Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.

Background: Controversy exists over the relationship between postoperative complications (POCs) and long-term survival for hepatocellular carcinoma (HCC) after hepatectomy. This study aimed to evaluate the impact of POCs on overall survival (OS) and disease-free survival (DFS) for HCC after liver resection.

Patients And Methods: The PubMed, EMBASE, and Cochrane Library databases were used to search for eligible studies published through 18 April 2020, and studies comparing the long-term outcomes between HCC patients with and without POCs after hepatectomy were included. Read More

View Article and Full-Text PDF

Successful defibrotide treatment of a patient with veno-occlusive disease after living-donor liver transplantation: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26463

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery.

Rationale: Veno-occlusive disease (VOD) is characterized by painful hepatomegaly, ascites, weight gain, and jaundice with nonthrombotic, fibrous obliteration of the centrilobular hepatic veins. VOD after liver transplantation is a rare complication, with an incidence of approximately 2%; however, it can be life-threatening in severe cases. The precise etiology and mechanism of VOD after liver transplantation remains unclear. Read More

View Article and Full-Text PDF

Hemophagocytic lymphohistiocytosis occurring after liver transplantation: A case series and review of the literature.

Clin Transplant 2021 Jun 23. Epub 2021 Jun 23.

Recanati-Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease characterized by excessive inflammation and tissue destruction due to a dysregulated immune response. Its secondary form is most commonly triggered by viral infection or malignancy. There have previously been 11 cases of acquired HLH described following liver transplantation in adult transplant recipients, most occurring within the first year following transplantation. Read More

View Article and Full-Text PDF

Acute Liver Failure in Sickle Cell Disease: A Perfect Storm.

Cureus 2021 Jun 16;13(6):e15680. Epub 2021 Jun 16.

Medical Oncology, Sinai Hospital of Baltimore, Baltimore, USA.

Sickle cell hepatopathy is a well-described but uncommonly seen complication of sickle cell disease and is usually caused by multiple overlapping processes. A more acute liver complication is hepatic sequestration which is important to recognize in order to initiate life-saving treatment. A 33-year-old woman with sickle cell disease complicated by painful crises, splenic infarction and significant alcohol abuse presented with gastrointestinal distress, pain crisis, acute-on-chronic anemia, and hyperbilirubinemia in the setting of greater than baseline alcohol consumption. Read More

View Article and Full-Text PDF

Clinical Manifestations and Characterization of COVID-19 in Liver Transplant Recipients: A Systematic Review of Case Reports and Case Series.

Ethiop J Health Sci 2021 Mar;31(2):429-438

Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Background: This systematic review is conducted to explore available information on clinical presentations, laboratory finding and outcomes of SARS-COV-2 in liver transplant patients.

Methods: We searched four databases for relevant terms related to COVID-19 and liver transplantation and collected both case reports and case series on liver transplantation published up to the end of September 2020.

Results: After initial screening of irrelevant articles, 25 studies were included and analyzed in this review. Read More

View Article and Full-Text PDF

Clinical value and limitations of the preoperative C-reactive-protein-to-albumin ratio in predicting postoperative morbidity and mortality after deceased-donor liver transplantation: a retrospective single-centre study.

Transpl Int 2021 Jun 22. Epub 2021 Jun 22.

Department of General, Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, Germany.

Background: Liver transplantation is still associated with a high risk of severe complications and postoperative mortality. This study examines the predictive value of the preoperative C-reactive-protein-to-albumin ratio (CAR) regarding perioperative morbidity and mortality in deceased-donor liver transplantation (DDLT) recipients.

Methods: In total, 390 DDLT recipients between 05/2010 and 03/2020 were eligible. Read More

View Article and Full-Text PDF

Early post-liver transplantation infections and their effect on long term survival.

Transpl Infect Dis 2021 Jun 21:e13673. Epub 2021 Jun 21.

Department of Medicine D and the Liver Institute, Rabin medical center, Beilinson Hospital, Petah-Tikva, Israel.

Background: Infections post-liver transplantation are major drivers for morbidity and mortality. However, the impact of infections within 180 days post-liver transplantation on long-term survival is not clear.

Methods: We present a retrospective cohort of 317 liver transplant patients for whom all infectious episodes were prospectively collected during a mean follow-up of 4. Read More

View Article and Full-Text PDF

Role of Tacrolimus C/D Ratio in the First Year After Pediatric Liver Transplantation.

Front Pediatr 2021 2;9:659608. Epub 2021 Jun 2.

Department of Pediatrics II, Pediatric Gastroenterology, Hepatology and Liver Transplantation, University Children's Hospital, Essen, Germany.

The calcineurin inhibitor (CNI) tacrolimus (TAC) is a cornerstone agent in immunosuppressive therapy in pediatric liver transplantation (LTX). Adverse effects limit the use of CNI. In adults, calculating the individual TAC metabolism rate allows to estimate the transplant recipient's risk for therapy-associated complications. Read More

View Article and Full-Text PDF

Allotransplantation of donor rectus fascia for abdominal wall closure in transplant patients: A systematic review.

Transplant Rev (Orlando) 2021 Jun 4;35(4):100634. Epub 2021 Jun 4.

Department of Abdominal Surgery, University Hospitals Leuven, Belgium.

Background: Abdominal wall closure after intestinal, multivisceral or liver transplantation can be a major challenge. Different surgical techniques have been described to close complex abdominal wall defects, but results remain variable. Two promising transplant techniques have been developed using either non-vascularized or vascularized donor rectus fascia. Read More

View Article and Full-Text PDF

Pulmonary infection after hepatic resection: associated factors and impact on outcomes.

Clin Res Hepatol Gastroenterol 2021 Jun 16:101733. Epub 2021 Jun 16.

Department of Anesthesiology and Critical Care, GRC 29, DREAM DMU, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne University, Paris, France; Department of Digestive Surgery, HPB Surgery, and Liver Transplantation, Pitié-Salpêtrière & Charles-Foix University Hospitals, Sorbonne University, Paris, France. Electronic address:

Background And Aims: Postoperative pulmonary complications are frequent after hepatectomy. The aim of this retrospective study was to use preoperative and intraoperative data to establish specific factors associated with post-hepatectomy pneumonia (PHPN).

Methods: Patients underwent minor or major hepatectomy for cancer or non-cancer treatment. Read More

View Article and Full-Text PDF

ASO Author Reflections: Impact of Postoperative Complications on Long-Term Survival After Resection of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Ann Surg Oncol 2021 Jun 18. Epub 2021 Jun 18.

Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

View Article and Full-Text PDF

Hyponatremia and Liver Transplantation: A Narrative Review.

J Cardiothorac Vasc Anesth 2021 May 23. Epub 2021 May 23.

Department of Anesthesiology and Perioperative Medicine, Penn State Health, Milton S. Hershey Medical Center/Penn State College of Medicine, Hershey, PA.

Hyponatremia is a common electrolyte disorder in patients with end-stage liver disease (ESLD) and is associated with increased mortality on the liver transplantation (LT) waiting list. The impact of hyponatremia on outcomes after LT is unclear. Ninety-day and one-year mortality may be increased, but the data are conflicting. Read More

View Article and Full-Text PDF

Noninvasive Management of Complications From Splenic Artery Aneurysm Embolization After Liver Transplant: A Case Report.

Exp Clin Transplant 2021 Jun 17. Epub 2021 Jun 17.

From the Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Splenic artery aneurysms are more common in patients with cirrhosis than in the general population. We report the case of a patient with a history of an orthotopic liver transplant who developed an enlarging splenic artery aneurysm that was treated with splenic artery embolization. He developed extensive portal vein thrombosis and subsequently splenic abscess. Read More

View Article and Full-Text PDF

Contrast Enhanced Ultrasound in Detecting Biliary Complications After ABO-Incompatible Liver Transplantation.

Prog Transplant 2021 Jun 18:15269248211024619. Epub 2021 Jun 18.

Division of Diagnostic and Interventional Ultrasound in Transplantations, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

View Article and Full-Text PDF

New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases.

Front Cell Dev Biol 2021 1;9:670273. Epub 2021 Jun 1.

Hospital Regional de Alta Especialidad de Ciudad Victoria "Bicentenario 2010", Ciudad Victoria, Mexico.

Visceral obesity is an important component of metabolic syndrome, a cluster of diseases that also includes diabetes and insulin resistance. A combination of these metabolic disorders damages liver function, which manifests as non-alcoholic fatty liver disease (NAFLD). NAFLD is a common cause of abnormal liver function, and numerous studies have established the enormously deleterious role of hepatic steatosis in ischemia-reperfusion (I/R) injury that inevitably occurs in both liver resection and transplantation. Read More

View Article and Full-Text PDF

Hepatic Encephalopathy: From Metabolic to Neurodegenerative.

Neurochem Res 2021 Jun 15. Epub 2021 Jun 15.

Hepato-Neuro Laboratory, CRCHUM, Université de Montréal, 900, rue Saint-Denis Pavillon R, R08.422, Montreal, QC, H2X-0A9, Canada.

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome of both acute and chronic liver disease. As a metabolic disorder, HE is considered to be reversible and therefore is expected to resolve following the replacement of the diseased liver with a healthy liver. However, persisting neurological complications are observed in up to 47% of transplanted patients. Read More

View Article and Full-Text PDF

A Complication Profile of Total Hip and Knee Arthroplasty in Liver Transplantation Patients: A Meta-Analysis.

J Arthroplasty 2021 May 21. Epub 2021 May 21.

Department of Orthopedics and Rehabilitation, University of Massachusetts Memorial Medical Center, Worcester, MA.

Background: There is an increasing demand for total joint arthroplasty in liver transplantation patients. However, significant heterogeneity in existing studies creates difficulty to draw conclusions on the risk profile of arthroplasty in this population.

Methods: A systematic review of the literature dated from 1980 to 2020 describing the complication rates of liver transplantation patients receiving either total hip or knee arthroplasty was conducted. Read More

View Article and Full-Text PDF

Causes and Circumstances of Death in Portopulmonary Hypertension.

Transplant Direct 2021 Jul 8;7(7):e710. Epub 2021 Jun 8.

Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

The causes and circumstances surrounding death are poorly studied in patients with portopulmonary hypertension (PoPH). We sought to determine the specific reasons for dying and characteristics surrounding this process in patients with PoPH.

Methods: All deaths of patients with PoPH followed in the Cleveland Clinic Pulmonary Vascular Program were prospectively reviewed by the pulmonary hypertension team between 1996 and 2020. Read More

View Article and Full-Text PDF

Biliary and duodenal complications after « en bloc» liver-small bowel transplantation in children. A single center cohort study.

Pediatr Transplant 2021 Jun 13:e14014. Epub 2021 Jun 13.

Pediatric Surgery, Hôpital Universitaire Necker-Enfants Malades, APHP, Paris, France.

Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series.

Methods: Between 1994 and 2020, 54 L-BT were performed in 53 children. Read More

View Article and Full-Text PDF

A prediction score model and survival analysis of acute kidney injury following orthotopic liver transplantation in adults.

Ann Palliat Med 2021 May 24. Epub 2021 May 24.

Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Acute kidney injury (AKI) is one of the postoperative complications following orthotopic liver transplantation (OLT), and is related to the high morbidity and mortality. Although there were numerous propensity factors for AKI, their cumulative influence remains unclear. Our aims were to develop a score model to predict postoperative AKI and to evaluate the impact of AKI on the recipients' long-term survival. Read More

View Article and Full-Text PDF

Utility of preoperative CT-based body metrics in relation to postoperative complications in pediatric liver transplant recipients.

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Computed tomography (CT) derived body metrics such as skeletal muscle index (SMI), psoas muscle index (PMI), and subcutaneous fat index (ScFI) are measurable components of sarcopenia, frailty, and nutrition. While these body metrics are advocated in adults for predicting postoperative outcomes after liver transplantation (LT), little is known about the value in pediatric populations. This study assessed the relation between preoperative CT-based body metrics and postoperative short-term outcomes in pediatric LT recipients. Read More

View Article and Full-Text PDF

Liver transplantation and bariatric surgery: a new surgical reality: a systematic review of the best time for bariatric surgery.

Updates Surg 2021 Jun 12. Epub 2021 Jun 12.

Fluminense Federal University, Niterói, RJ, Brazil.

Non-alcoholic fatty liver disease has increased in parallel with the obesity. This situation represents a new reality for patients with an indication for liver transplant (LT) and bariatric surgery (BS). We undertook a systematic review of BS and LT using the terms 'liver transplant', 'obesity' and 'bariatric surgery'. Read More

View Article and Full-Text PDF

Diagnostic delay and misdiagnosis in eosinophilic oesophagitis.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. Electronic address:

Background: Eosinophilic oesophagitis (EoE) may lead to severe complications if not promptly recognised.

Aims: To assess the diagnostic delay in patients with EoE and to explore its risk factors.

Methods: EoE patients followed-up at eight clinics were included via retrospective chart review. Read More

View Article and Full-Text PDF

Combined stoma reversal and liver resection for rectal metastatic cancer: A single center retrospective analysis.

J Visc Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France.

Goal Of The Study: Concomitant liver metastases are discovered at the time of diagnosis in 25% of patients with colorectal cancers. The appropriate time to restore digestive continuity after stoma creation during rectal surgery has not yet been established. The objective of this study is to assess the morbidity of stoma reversal during the secondary hepatectomy procedure. Read More

View Article and Full-Text PDF

Postoperative incision scars and cosmetic satisfaction of living liver donors.

Medicine (Baltimore) 2021 Jun;100(23):e26187

Department of General Surgery, Changhua Christian Hospital, Changhua.

Abstract: Cosmetic appearance is a major concern for living donors. However, little is known about the impact of a surgical scar on body image changes in living liver donors. The aim of this study was to identify potential factors that cause displeasing upper midline incision scar, and to evaluate the overall satisfaction regarding body image and scarring after living donor hepatectomy. Read More

View Article and Full-Text PDF

Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation.

Int J Hematol 2021 Jun 10. Epub 2021 Jun 10.

Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Patients with hepatitis-associated aplastic anemia (HAA) who undergo living-donor liver transplantation (LDLT) have a poor prognosis with infections and bleeding complications. Rapid recovery of blood cells is critical for preventing these complications and improving the outcome. Immunosuppressive therapy (IST) combined with thrombopoietin receptor agonists is considered effective for aplastic anemia. Read More

View Article and Full-Text PDF

Portal vein obstruction after pediatric liver transplantation: A systematic review of current treatment strategies.

Transplant Rev (Orlando) 2021 May 29;35(4):100630. Epub 2021 May 29.

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Introduction: Portal vein obstruction (PVO) is a significant vascular complication after liver transplantation (LT) in pediatric patients. Current treatment strategies include percutaneous transluminal angioplasty (PTA), with or without stent placement, mesorex bypass (MRB), splenorenal shunt, mesocaval shunt, endovascular recanalization (EVR), splenic artery embolization and splenectomy. However, specific characteristics of patients undergoing intervention and selection of individual treatment and its efficacy have remained unclear. Read More

View Article and Full-Text PDF