37,396 results match your criteria Liver Transplantation Complications


PO 21% oxygenated hypothermic machine perfusion in kidney transplantation: Any clinical benefit?

Int J Artif Organs 2022 Jun 24:3913988221107946. Epub 2022 Jun 24.

Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy.

Background: In deceased donor kidney transplantation (KT), the use of hypothermic machine perfusion (HMP) has been acquiring the status of best practice in the pre-transplant management of kidney grafts. Two types of HMP are currently available, oxygenated HMP and non-oxygenated HMP. However, data on the real clinical impact of oxygenation on KT outcome are still heterogeneous. Read More

View Article and Full-Text PDF

Graft aberrant hepatic arteries in deceased donor liver transplantation: the "one liver, one artery" approach.

Liver Transpl 2022 Jun 24. Epub 2022 Jun 24.

Department of HPB Surgery and Liver Transplantation, AP-HP Beaujon Hospital, University of Paris, Clichy, France.

In liver transplantation (LT), graft aberrant hepatic arteries (aHA) frequently require complex arterial reconstructions, potentially increasing the risk of postoperative complications. However, intrahepatic hilar arterial shunts are physiologically present and may allow selective aHA ligation. Thus, we performed a retrospective study from a single-center cohort of 618 deceased-donor LT (DDLT) where a selective reconstruction policy of aHA was prospectively applied. Read More

View Article and Full-Text PDF

Treatment of Hepatitis Delta and HIV Infection.

Liver Int 2022 Jun 24. Epub 2022 Jun 24.

Public Health Regional Laboratory, Hospital Isabel Zendal, Madrid, Spain.

Hepatitis delta virus (HDV) is a defective agent that only infects individuals with hepatitis B virus (HBV). Around 5-10% of chronic hepatitis B patients worldwide are superinfected with HDV, which means 15-25 million people. Hepatitis delta is the most severe of all chronic viral hepatitis, leading to cirrhosis, liver cancer and/or transplantation in most patients. Read More

View Article and Full-Text PDF

Intracholecystic versus Intravenous Indocyanine Green (ICG) Injection for Biliary Anatomy Evaluation by Fluorescent Cholangiography during Laparoscopic Cholecystectomy: A Case-Control Study.

J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.

(1) Background: Fluorescence cholangiography has been proposed as a method for improving the visualization and identification of extrahepatic biliary anatomy in order to possibly reduce injuries and related complications. The most common method of indocyanine green (ICG) administration is the intravenous route, whereas evidence on direct ICG injection into the gallbladder is still quite limited. We aimed to compare the two different methods of ICG administration in terms of the visualization of extrahepatic biliary anatomy during laparoscopic cholecystectomy (LC), analyzing differences in the time of visualization, as well as the efficacy, advantages, and disadvantages of both modalities. Read More

View Article and Full-Text PDF

Combination of Hemoglobin-for-Age Z-Score and Plasma Hepcidin Identified as a Novel Predictor for Kawasaki Disease.

Children (Basel) 2022 Jun 18;9(6). Epub 2022 Jun 18.

Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Kawasaki disease (KD) is a febrile coronary vasculitis that affects younger children and includes complications such as coronary artery aneurysm. KD diagnoses are diagnosed based on clinical presentations, a process that still poses a challenge for front-line physicians. In the current study, we developed a novel predictor using the hemoglobin-for-age z-score (HbZ) and plasma hepcidin to differentiate Kawasaki disease (KD) from febrile children (FC). Read More

View Article and Full-Text PDF

Comparable clinical outcomes of haploidentical hematopoietic stem cell transplantation in patients with hepatitis-associated aplastic anemia and non-hepatitis-associated aplastic anemia.

Ann Hematol 2022 Jun 23. Epub 2022 Jun 23.

National Clinical Research Centre for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplant, Peking University People's Hospital, Peking University Institute of Hematology, No. 11 Xizhimen South Street, Xicheng District, 100044, Beijing, China.

Hepatitis-associated aplastic anemia (HAAA), a rare subtype of aplastic anemia (AA), is defined as bone marrow failure occurring after acute hepatitis. Severe HAAA requires immunosuppressive therapy (IST) or hematopoietic stem cell transplantation (HSCT) as lifesaving treatment. The outcomes of HAAA patients who underwent haploidentical hematopoietic stem cell transplantation (haplo-HSCT) have not been systematically evaluated. Read More

View Article and Full-Text PDF

Laparoscopic versus open liver resection for resectable HCC with BCLC stage B: a propensity score-matched analysis.

Updates Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Liver Surgery, Center of Liver Transplantation, West China Hospital of Sichuan University, No. 37 Guoxuexiang, Chengdu, Sichuan Province, China.

To date, there is little knowledge about the value of laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) patients with Barcelona Clinic Liver Cancer (BCLC) stage B. Thus, this study was performed to assess the perioperative and oncological outcomes of LLR for these patients by comparison with open liver resection (OLR). Between April 2015 and October 2018, a total of 217 resectable HCC patients with BCLC stage B were eligible for this study. Read More

View Article and Full-Text PDF

Porto-pulmonary arterial hypertension: Translation of pathophysiological concepts to the bedside.

Vascul Pharmacol 2022 Jun 20;145:107022. Epub 2022 Jun 20.

Cardiovascular Division, Pisa University Hospital and University of Pisa, Pisa, Italy.

Porto-pulmonary arterial hypertension (PoPAH) is a form of pulmonary arterial hypertension (PAH) that affects patients with cirrhosis, and - to a lesser extent - patients with non-cirrhotic liver diseases. Compared with other forms of PAH, PoPAH is more prevalent in male, in older subjects, and is characterized by lower mean pulmonary arterial pressure (mPAP) and lower pulmonary vascular resistance (PVR) with higher cardiac output. Despite more favorable hemodynamics and functional class, patients with PoPAH have a significantly worse survival than patients with other forms of PAH, likely because of liver-related events and therapeutic barriers to PAH-specific therapy. Read More

View Article and Full-Text PDF

Impact of allograft types on outcomes after pediatric liver transplantation due to biliary atresia.

Pediatr Transplant 2022 Jun 23:e14342. Epub 2022 Jun 23.

Department of Pediatric transplantation, Organ Transplantation Center, Tianjin First Central Hospital, Tianjin, China.

Background: Several surgical strategies, including split donor transplantation and living donor transplantation, have been used to increase the donor liver pool. This report focuses on the effects of whole, split, and LDLT on recipient outcomes.

Methods: We retrospectively analyzed the records of all patients with biliary atresia at Tianjin First Central Hospital between April 2013 and December 2019. Read More

View Article and Full-Text PDF

Hepatic and portal vein transection by vascular stapler in open living donor hepatectomy - A retrospective cohort study.

Ann Med Surg (Lond) 2022 Jun 18;78:103823. Epub 2022 May 18.

Division of General, Hepatobiliary and Transplant Surgery, Jordan Hospital, Amman, Jordan.

Background: In an effort to increase donor safety in living donor liver transplantation, the utilization of vascular staplers for the division of the right portal and hepatic veins in patients undergoing right lobe liver donation for living donor liver transplantation (LDLT) was implemented. In here we report our experience with vascular staplers in patients undergoing LDLT and evaluate the subsequent feasibility and safety for donors.

Material And Methods: 17 cases of living donor liver transplant were retrospectively analyzed. Read More

View Article and Full-Text PDF

Role of surgical treatments in high-grade or advanced gastroenteropancreatic neuroendocrine neoplasms.

World J Gastrointest Surg 2022 May;14(5):397-408

Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China.

Over the last 40 years, the incidence and prevalence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have continued to increase. Compared to other epithelial neoplasms in the same organ, GEP-NENs exhibit indolent biological behavior, resulting in more chances to undergo surgery. However, the role of surgery in high-grade or advanced GEP-NENs is still controversial. Read More

View Article and Full-Text PDF

Normothermic regional perfusion in liver transplantation from donation after cardiocirculatory death: Technical, biochemical, and regulatory aspects and review of literature.

Artif Organs 2022 Jun 22. Epub 2022 Jun 22.

Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.

Background: Organs from donation after circulatory death (DCD) are increasingly used for liver transplantation, due to the persisting organ shortage and waiting list mortality. However, the use of DCD grafts is still limited by the inferior graft survival rate and the increased risk of primary non-function and biliary complications when compared to brain death donors' grafts.

Methods: Abdominal normothermic regional perfusion with extracorporeal membrane oxygenation (ECMO) is an in situ preservation strategy. Read More

View Article and Full-Text PDF

MR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertension.

Eur Radiol 2022 Jun 21. Epub 2022 Jun 21.

BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objectives: Portal hypertension (PH) is associated with complications such as ascites and esophageal varices and is typically diagnosed through invasive hepatic venous pressure gradient (HVPG) measurement, which is not widely available. In this study, we aim to assess the diagnostic performance of 2D/3D MR elastography (MRE) and shear wave elastography (SWE) measures of liver and spleen stiffness (LS and SS) and spleen volume, to noninvasively diagnose clinically significant portal hypertension (CSPH) using HVPG measurement as the reference.

Methods: In this prospective study, patients with liver disease underwent 2D/3D MRE and SWE of the liver and spleen, as well as HVPG measurement. Read More

View Article and Full-Text PDF

Post-Transplantation Cytomegalovirus Infection Interplays With the Development of Anastomotic Biliary Strictures After Liver Transplantation.

Transpl Int 2022 2;35:10292. Epub 2022 Jun 2.

Department of Digestive Surgical Oncology -Liver Transplantation Unit, University Hospital of Besançon, Besancon, France.

Anastomotic biliary stricture (ABS) remains the most frequent complication after liver transplantation (LT). This study aimed to identify new anastomotic biliary stricture risk factors, with a specific focus on postoperative events. Additionally, ABS management and impact on patient and graft survival were assessed. Read More

View Article and Full-Text PDF

Role of biliary complications in chronic graft rejection after living donor liver transplantation.

World J Hepatol 2022 May;14(5):1050-1052

Department of Pathology, Faculty of Medicine, University Augsburg, Augsburg 86156, Germany.

Postoperative biliary complications remain a substantial challenge after living donor liver transplantation, especially due to its heterogeneous clinical presentation. Read More

View Article and Full-Text PDF

Biliary obstruction following transjugular intrahepatic portosystemic shunt placement in a patient after liver transplantation: A case report.

World J Hepatol 2022 May;14(5):1038-1046

Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague 14021, Czech Republic.

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a method used to decrease portal hypertension. Biliary stricture is the rarest of the complications associated with this procedure with only 12 cases previously reported in the literature. None of these cases have documented the resolution of biliary stenosis induced by a stent graft. Read More

View Article and Full-Text PDF

Outcome of Split Liver Transplantation from Pediatric Donors Weighing 25 kg or Less.

Liver Transpl 2022 Jun 17. Epub 2022 Jun 17.

Organ Transplantation Center, Tianjin, Tianjin, China.

The lower limit of body weight for "splitable" liver grafts remains unknown. To examine the outcome of split liver transplantation (SLT) from pediatric donors ≤ 25 kg relative to conventional graft type liver transplantation from deceased donors under corresponding conditions, a total of 158 patients who received primary liver transplantation, including 22 SLTs from donors ≤ 25 kg, 46 SLTs from donors > 25 kg, 76 whole liver transplantations (WLTs) and 14 reduced liver transplantations (RLTs) in donors ≤ 25 kg, between January 2018 and December 2019 were included in the study. There was no significant difference in the complications, patient survival and graft survival between each of the latter three groups and SLT ≤ 25 kg group. Read More

View Article and Full-Text PDF

Downregulation of thrombomodulin contributes to ischemia-reperfusion injury in mice with steatotic liver.

Hepatol Res 2022 Jun 17. Epub 2022 Jun 17.

Department of Gastroenterological and Transplant Surgery, Hiroshima University Hospital, Hiroshima, Japan.

Aim: Ischemia-reperfusion (IR) injury is one of the most critical complications commonly associated with liver surgery, including liver transplantation. Steatotic livers are particularly vulnerable to IR injury. However, the underlying mechanisms of this increased susceptibility have not fully been understood. Read More

View Article and Full-Text PDF

Infection in Liver Cirrhosis: A Concise Review.

Can J Gastroenterol Hepatol 2022 7;2022:4209442. Epub 2022 Jun 7.

Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhang Zhidong Road, Wuhan 430000, Hubei, China.

is a Gram-positive bacillus with fecal-oral transmission and is currently one of the most common nosocomial infections worldwide, which was renamed in 2016. infection (CDI) is a prevalent infection in cirrhosis and negatively affects prognosis. This study aimed to provide a concise review with clinical practice implications. Read More

View Article and Full-Text PDF

Biliary Viability Assessment and Treatment Options of Biliary Injury During Normothermic Liver Perfusion-A Systematic Review.

Transpl Int 2022 30;35:10398. Epub 2022 May 30.

Department of General Surgery, Division of Transplantation, Medical University of Vienna, Vienna, Austria.

In recent years, significant progress has been made in the field of liver machine perfusion. Many large transplant centers have implemented machine perfusion strategies in their clinical routine. Normothermic machine perfusion (NMP) is primarily used to determine the quality of extended criteria donor (ECD) organs and for logistical reasons. Read More

View Article and Full-Text PDF

Laparoscopic assisted liver transplantation: a realistic perspective.

Am J Transplant 2022 Jun 15. Epub 2022 Jun 15.

AP-HP, Beaujon hospital, Department of HPB surgery and liver transplantation, DMU DIGEST, Clichy, France.

Laparoscopic approach was rarely described in recipients for liver transplantation (LT). We report the feasibility and safety of laparoscopic-assisted LT (LA-LT) in patients with unresectable liver metastases of neuroendocrine tumors. Total hepatectomy was performed laparoscopically with graft implantation through an upper midline incision. Read More

View Article and Full-Text PDF

Pediatric Subjects With Cirrhosis Are Not at a Higher Risk of Bleeding or Clotting due to a Rebalanced Hemostatic System.

Transplantation 2021 Dec 16;105(12S2):S2. Epub 2021 Dec 16.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition.

View Article and Full-Text PDF
December 2021

Single Center Experience with Incidence, Impact and Predictors of Biliary Complications in Donation After Circulatory Death Liver Transplantation.

Prog Transplant 2022 Jun 14:15269248221107039. Epub 2022 Jun 14.

209825Department of Surgery, Division of Transplantation, Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA.

Utilizing allografts from donors after cardiac death (DCD) has improved organ availability, and DCD livers comprise a growing proportion of transplantations. However, it has been suggested that DCD transplantations have worse outcomes. We aimed to characterize outcomes in a large cohort of DCD transplantations, identify trends in outcomes over time, and identify factors associated with the development of biliary complications. Read More

View Article and Full-Text PDF

Comparative study of indocyanine green (ICG)-R15 and Albumin-Indocyanine Green Evaluation (ALICE) grading system in the prediction of posthepatectomy liver failure and postoperative mortality in patients with hepatic alveolar echinococcosis.

BMC Gastroenterol 2022 Jun 14;22(1):297. Epub 2022 Jun 14.

Department of Hepatobiliary-Pancreatic Surgery, Cell Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Qingyang District, Chengdu, 610072, Sichuan, China.

Background: A precise evaluation of liver reserve function in patients with hepatic alveolar echinococcosis (HAE) prior to hepatectomy could substantially increase the success rate of the operation and reduce the incidence of postoperative complications. The present study aimed to investigate the significance of the indocyanine green retention test at 15 min (ICG-R15) and the Albumin-Indocyanine Green Evaluation (ALICE) grading system in predicting severe posthepatectomy liver failure (PHLF) and postoperative mortality in HAE patients undergoing liver resection.

Methods: A total of 105 HAE patients undergoing hepatectomy were enrolled in this study. Read More

View Article and Full-Text PDF

Three-dimensional modeling in complex liver surgery and liver transplantation.

Hepatobiliary Pancreat Dis Int 2022 Jun 1. Epub 2022 Jun 1.

Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital, Zhejiang Shuren University School of Medicine, Hangzhou 310000, China; Division of Hepatobiliary Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; National Clinical Research Center of Infectious Diseases, Hangzhou 310003, China. Electronic address:

Liver resection and transplantation are the most effective therapies for many hepatobiliary tumors and diseases. However, these surgical procedures are challenging due to the anatomic complexity and many anatomical variations of the vascular and biliary structures. Three-dimensional (3D) printing models can clearly locate and describe blood vessels, bile ducts and tumors, calculate both liver and residual liver volumes, and finally predict the functional status of the liver after resection surgery. Read More

View Article and Full-Text PDF

The impact of low recipient weight [≤ 7kg] on long-term outcomes in 1078 pediatric living donor liver transplantations.

J Pediatr Surg 2022 May 22. Epub 2022 May 22.

Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro, 414, cj 65, Bela Vista, SP, Brazil; Hepatology and Liver Transplantation, A. C. Camargo Cancer Center, São Paulo, SP, Brazil; Hospital Municipal Infantil Menino Jesus, São Paulo, SP, Brazil.

Background: infants who require liver transplantation represent a treatment challenge because chronic liver disease at this early age affects the child's growth and development during a critical phase. The aim is to compare demographics, operative data, and long-term outcomes according to recipient weight at the time of LDLT.

Methods: This retrospective study included primary LDLT analyzed in 2 groups: BW ≤ 7 kg (n = 322) and BW > 7 kg (n = 756). Read More

View Article and Full-Text PDF

Bioabsorbable Glycolide Copolymer is Effective in Reducing Staple Line Bleeding in Sleeve Gastrectomy.

Obes Surg 2022 Jun 13. Epub 2022 Jun 13.

Digestive Surgery Unit, Centre Hospitalier Universitaire de Guadeloupe, 97159, Pointe à Pitre, Guadeloupe.

Background: Postoperative bleeding from the staple line after sleeve gastrectomy occurs in 2-8% of patients and it is associated with increased length and cost of hospitalization and may demand reoperation to gain hemostasis. Reinforced staplers are used by bariatric surgeons to reduce the incidence of postoperative leak but can have a role in avoiding bleeding. The aim of this study is to analyze the effects of reinforcement on the whole gastric staple line during sleeve gastrectomy on postoperative bleeding. Read More

View Article and Full-Text PDF

Impact of living donor liver with steatosis and idiopathic portal inflammation on clinical outcomes in pediatric liver transplantation: Beijing experience.

Hepatobiliary Surg Nutr 2022 Jun;11(3):340-354

Liver Transplant Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: To evaluate the impact of steatosis and/or idiopathic portal inflammation (IPI) in living donor livers on recipients' clinical outcomes.

Methods: We assessed 305 qualified donor liver samples from June 2013 to December 2018. Donors and recipients' clinical characteristics, including follow-up data were retrieved. Read More

View Article and Full-Text PDF

Identification and treatment of biliary complications after liver transplantation: more relevant than ever.

Hepatobiliary Surg Nutr 2022 Jun;11(3):443-445

Department of Surgery, Campus Charité Mitte/Campus Virchow-Klinikum, Experimental Surgery, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

View Article and Full-Text PDF