31,018 results match your criteria Liver Transplantation Complications


The yield and safety of screening colonoscopy in patients evaluated for liver transplantation.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Hospital, Rotterdam, Netherlands.

Colorectal cancer screening with colonoscopy is commonly used in candidate patients for liver transplantation. We initiated this study to define the risk-benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre-liver transplantation screening between 2004-2017 was conducted. Read More

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http://dx.doi.org/10.1002/hep.30562DOI Listing
February 2019

Acute Hepatic Porphyrias: Review and Recent Progress.

Hepatol Commun 2019 Feb 20;3(2):193-206. Epub 2018 Dec 20.

Section of Gastroenterology and Hepatology, Department of Internal Medicine Wake Forest University School of Medicine Winston-Salem NC.

The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms. The four types are 5-aminolevulinic acid (ALA) dehydratase deficiency porphyria, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. Their diagnoses are often missed or delayed because the clinical symptoms mimic other more common disorders. Read More

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http://dx.doi.org/10.1002/hep4.1297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357830PMC
February 2019

Laparoscopic versus open adhesiolysis for adhesive small bowel obstruction (LASSO): an international, multicentre, randomised, open-label trial.

Lancet Gastroenterol Hepatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Although laparoscopic adhesiolysis for adhesive small bowel obstruction is being done more frequently, it is not widely accepted due to the lack of supporting evidence of its superiority over an open approach and concerns regarding its benefits. We aimed to investigate whether laparoscopic adhesiolysis was a superior treatment for adhesive small bowel obstruction compared with an open approach in terms of length of postoperative hospital stay and morbidity.

Methods: In this international, multicentre, parallel, open-label trial, we randomly assigned patients (1:1) aged 18-95 years who had adhesive small bowel obstruction that had not resolved with conservative management to have either open or laparoscopic adhesiolysis. Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30016-0DOI Listing
February 2019

Current status of graft-versus-host disease after intestinal transplantation.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Transplantation, Department of Surgery, Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Thomas E. Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Purpose Of Review: Over the past decades, visceral transplantation has become the standard of care for patients with irreversible intestinal failure who suffer complications of total parenteral nutrition (TPN). Graft-versus-host disease (GVHD) after solid organ transplantation is a rare but often fatal complication with high mortality. GVHD after intestinal transplantation, given the large lymphoid content of the graft, is more frequent compared with other solid organs. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000624DOI Listing
February 2019
2 Reads

Irreversible Electroporation as a Bridge to Liver Transplantation.

Am Surg 2019 Jan;85(1):103-110

Hepatocellular carcinoma (HCC) in proximity to major hepatic vasculature poses a risk for invasion, which would contraindicate liver transplantation, yet, is difficult to treat with thermal ablation. This study was undertaken to evaluate the feasibility of irreversible electroporation (IRE) as a bridge to transplantation for high-risk tumors. All patients with HCC in proximity to major hepatic vasculature treated with laparoscopic IRE as bridge to transplantation were studied. Read More

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January 2019

Assessment of Anastomotic Biliary Complications in Adult Patients Undergoing High-Acuity Liver Transplant.

JAMA Surg 2019 Feb 13. Epub 2019 Feb 13.

Dumont-UCLA (University of California, Los Angeles) Transplant and Liver Cancer Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, UCLA.

Importance: Anastomotic biliary complications (ABCs) constitute the most common technical complications in liver transplant (LT). Given the ever-increasing acuity of LT, identification of factors contributing to ABCs is essential to minimize morbidity and optimize outcomes. A detailed analysis in a patient population undergoing high-acuity LT is lacking. Read More

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http://dx.doi.org/10.1001/jamasurg.2018.5527DOI Listing
February 2019

Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!

Clin Sci (Lond) 2019 Feb 12;133(3):465-481. Epub 2019 Feb 12.

Laboratory of Hepato-Gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain (UCLouvain), Brussels, Belgium

Skeletal muscle is a tissue that represents 30-40% of total body mass in healthy humans and contains up to 75% of total body proteins. It is thus the largest organ in non-obese subjects. The past few years have seen increasing awareness of the prognostic value of appreciating changes in skeletal muscle compartment in various chronic diseases. Read More

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http://dx.doi.org/10.1042/CS20180421DOI Listing
February 2019

The impact of extra-anatomical hepatic artery reconstruction during living donor liver transplantation on biliary complications and graft and patient survival.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

Background: This study was designed to analyze the feasibility of extra-anatomical hepatic artery reconstruction in living donor liver transplantation.

Methods: Patients who underwent their first living donor liver transplantation at our center between January 2008 and December 2017 were reviewed. Hepatic artery reconstruction was classified as anatomical or extra-anatomical reconstruction. Read More

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http://dx.doi.org/10.1097/TP.0000000000002601DOI Listing
February 2019

Preventive effect of bariatric surgery on type 2 diabetes onset in morbidly obese inpatients: a national French survey between 2008 and 2016 on 328,509 morbidly obese patients.

Surg Obes Relat Dis 2019 Jan 8. Epub 2019 Jan 8.

Université Côte d'Azur, Nice, France; Centre Hospitalier Universitaire de Nice, Digestive Surgery and Liver Transplantation Unit, Archet 2 Hospital, Nice, France; U1065, Team 8 "Hepatic complications of obesity", Inserm, Nice, France. Electronic address:

Background: The association between bariatric surgery (BS) and the prevention of type 2 diabetes (T2D) and its complications in patients with obesity has been rarely addressed in large, nationwide database studies.

Objective: To estimate the preventive effect of BS against T2D and its vascular complications in patients with obesity without co-morbidity at baseline.

Setting: All French public and private hospitals. Read More

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http://dx.doi.org/10.1016/j.soard.2018.12.028DOI Listing
January 2019

L-Cysteine supplementation prevents liver transplantation in a patient with TRMU deficiency.

Mol Genet Metab Rep 2019 Jun 25;19:100453. Epub 2019 Jan 25.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.

Early recognition of rare mitochondrial respiratory chain defects has become readily available with the routine use of whole exome sequencing. Patients with oxidative phosphorylation defects present with a heterogenous phenotype, often rapidly progressive, and lethal. Clinicians aim for prompt identification of the specific molecular defect to provide timely management, decrease morbidity, and potentially improve survival rates. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355510PMC

Middle hepatic vein reconstruction in adult right lobe living donor liver transplantation improves recipient survival.

Hepatobiliary Pancreat Dis Int 2019 Jan 31. Epub 2019 Jan 31.

Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:

Background: The efficacy and necessity of middle hepatic vein (MHV) reconstruction in adult-to-adult right lobe living donor liver transplantation (LDLT) remain controversial. The present study aimed to evaluate the survival beneficiary of MHV reconstructions in LDLT.

Methods: We compared the clinical outcomes of liver recipients with MHV reconstruction (n = 101) and without MHV reconstruction (n = 43) who underwent LDLT using right lobe grafts at our institution from January 2006 to May 2017. Read More

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http://dx.doi.org/10.1016/j.hbpd.2019.01.006DOI Listing
January 2019

Liver and kidney function in refractory heart failure: The narrow gate to achieve post-transplant survival.

Clin Res Hepatol Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Advanced Heart Failure and Transplant Program, Bologna University Hospital, Bologna, Italy. Electronic address:

Substantial evidence is underscoring the importance of a combined assessment of liver and kidney function in patients with refractory heart failure, to stratify early post- heart transplant risk: multi-organ dysfunction, while identifying sickest patients on the list is also associated with a high risk of post transplant complications. In this issue of the Journal, Dr. Lebray provides an analysis of combined kidney and liver function patients undergoing heart transplant, identifying potential boundaries for futility of transplantation, because of excessive post-operative risk. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.04.004DOI Listing
February 2019
1 Read

Laparoscopic Living Donor Hepatectomy for Pediatric Liver Transplantation: the First 7 Cases in Spain.

Transplant Proc 2019 Jan - Feb;51(1):56-57. Epub 2018 Jun 30.

Liver Transplantation Unit, Department of General Surgery, University Reina Sofía Hospital, Instituto Maimónides de Investigaciones Biomédicas, CIBERehd, Córdoba, Spain.

Herein we report on laparoscopic donor hepatectomy (left lateral sectionectomy) for pediatric living donor liver transplantation by using a pure laparoscopic approach. Seven laparoscopic living donor procedures were performed during the period March 2016 to February 2017 at our institution. The average age of donors was 33. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.140DOI Listing
June 2018
1 Read

Selective Indication of T-Tube in Liver Transplantation: Prospective Validation of the Results of a Randomized Controlled Trial.

Transplant Proc 2019 Jan - Feb;51(1):44-49. Epub 2018 Jun 28.

HPB Surgery and Transplant Unit, La Fe University Hospital, Valencia, Spain.

Background And Aims: T-tube placement during choledochocholedochostomy (CCS) associated with liver transplantation (LT) remains controversial. This study was designed to validate the results of an earlier prospective randomized controlled trial (RCT) on use versus nonuse of the T-tube during CCS associated with LT.

Methods: Prospective cohort study. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.133DOI Listing

Preliminary Experience With Hypothermic Oxygenated Machine Perfusion in an Italian Liver Transplant Center.

Transplant Proc 2019 Jan - Feb;51(1):111-116. Epub 2018 Jun 30.

Liver Transplant and General Surgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Machine perfusion is increasingly utilized in liver transplantation to face the detrimental consequences of the use of extended-criteria donors. Hypothermic oxygenated machine perfusion (HOPE) appears to be more protective relative to static cold storage. Conversely, normothermic machine perfusion (NMP) allows a better graft evaluation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.070DOI Listing
June 2018
1 Read

Surgical outcomes and quality of life between laparoscopic and open approach for hepatic hemangioma: A propensity score matching analysis.

Medicine (Baltimore) 2019 Feb;98(6):e14485

Department of Liver Surgery, Center of Liver Transplantation, West China Hospital.

The main objective of the study was to compare the surgical outcomes and quality of life (QOL) of patients with hepatic hemangioma either by laparoscopic or open surgery using a propensity score analysis.We retrospectively reviewed patients with hepatic hemangioma undergoing laparoscopic liver surgery (LLS) or open liver surgery (OLS) between January 2016 and December 2017. Intraoperative and postoperative characteristics, and quality of life, according to Short Form-36 Healthy Survey (SF-36) questionnaire, were compared between groups. Read More

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http://dx.doi.org/10.1097/MD.0000000000014485DOI Listing
February 2019
1 Read

Multidisciplinary Management of Leaks After One-Anastomosis Gastric Bypass in a Single-Center Series of 2780 Consecutive Patients.

Obes Surg 2019 Feb 6. Epub 2019 Feb 6.

Digestive and Bariatric Surgery Unit, Hôpital Joseph Ducuing, 15 Rue Varsovie, 31027, Toulouse, France.

Purpose: Few data exist in the literature concerning leaks after one-anastomosis gastric bypass (OAGB). Our aim was to describe the incidence, presentation, and management of leaks after OAGB.

Setting: A private clinic in France. Read More

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http://link.springer.com/10.1007/s11695-019-03754-2
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http://dx.doi.org/10.1007/s11695-019-03754-2DOI Listing
February 2019
5 Reads

Laparoscopic Sleeve Gastrectomy After Orthotopic Liver Transplantation, Video Reported.

Obes Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of General Surgery, Center Hospitalier Intercommunal de Créteil, 40 Avenue de Verdun, 94000, Créteil, France.

Introduction: The immunosuppressive therapy for life after liver transplantation (LT) is considered as a risk factor for obesity. Seven percent of the transplanted patients develop severe or morbid obesity. The obesity induces non-alcoholic steatohepatitis (NASH), which is a major risk factor for liver cirrhosis and hepatocellular carcinoma, without forgetting the cardiovascular risk and the devastating impact of obesity on quality of life of the transplanted patients. Read More

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http://dx.doi.org/10.1007/s11695-019-03751-5DOI Listing
February 2019

Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Suite 7717, 85 E Concord St, Boston, MA, 02118, USA.

Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. Read More

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http://dx.doi.org/10.1007/s10620-019-05484-yDOI Listing
February 2019
1 Read

Entecavir and other nucleos(t)ide analogs prophylaxis in hepatitis B virus-related liver transplantation: long-term efficacy and safety.

Eur J Gastroenterol Hepatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Hepatogastroenterology and Tropical Medicine, Faculty of Medicine, Cairo University, Cairo.

Background And Aim: Although hepatitis B virus (HBV) recurrence after liver transplantation (LTx) has been reduced since the application of the combination of hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogs (NUCs), the optimum regimen to prevent HBV recurrence with LTx favorable outcome is still not clear.

Aim: The aim was to evaluate the efficacy and safety of NUCs prophylaxis (±HBIG) against HBV recurrence after LTx.

Patients And Methods: This was a retrospective cohort-longitudinal study on 44 HBV-related post-LTx patients on anti-HBV prophylactic therapy. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001377DOI Listing
February 2019
1 Read

Argininosuccinic aciduria: Recent pathophysiological insights and therapeutic prospects.

J Inherit Metab Dis 2019 Feb 5. Epub 2019 Feb 5.

Division of Metabolism and Children Research Centre (CRC), University Children's Hospital, Zurich, Switzerland.

The first patients affected by argininosuccinic aciduria (ASA) were reported 60 years ago. The clinical presentation was initially described as similar to other urea cycle defects, but increasing evidence has shown overtime an atypical systemic phenotype with a paradoxical observation, that is, a higher rate of neurological complications contrasting with a lower rate of hyperammonaemic episodes. The disappointing long-term clinical outcomes of many of the patients have challenged the current standard of care and therapeutic strategy, which aims to normalize plasma ammonia and arginine levels. Read More

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http://dx.doi.org/10.1002/jimd.12047DOI Listing
February 2019

Complex liver resection under hepatic vascular exclusion and hypothermic perfusion with versus without veno-venous bypass: a comparative study.

HPB (Oxford) 2019 Feb 2. Epub 2019 Feb 2.

Department of Hepato-Pancreatico-Biliary Surgery and Liver Transplant, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, 100 Boulevard du Général Leclerc, 92110, Clichy, France(4). Electronic address:

Background: While hypothermic liver perfusion has been shown to improve parenchymal tolerance to complex resections in patients requiring prolonged hepatic vascular exclusion (HVE), the benefit of associated veno-venous bypass (VVB) in this setting remains poorly evaluated.

Methods: All patients undergoing liver resection requiring HVE and hypothermic liver perfusion for at least 55 min between 2006 and 2017 were retrospectively reviewed. Perioperative outcomes were compared between patients with (VVB+) or without VVB (VVB-). Read More

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http://dx.doi.org/10.1016/j.hpb.2018.12.012DOI Listing
February 2019
1 Read

Association Between Sarcopenia and AFP Level in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.

J Surg Res 2019 Feb 2;238:10-15. Epub 2019 Feb 2.

Department of Radiology, University of Kentucky College of Medicine, Lexington, Kentucky.

Background: Sarcopenia is one of the most common complications of cirrhosis. Liver transplantation (LT) is the treatment of choice for patients with early-stage hepatocellular carcinoma (HCC) that are unsuitable for resection.

Methods: We performed a retrospective analysis of 163 patients transplanted at our institution with HCC from 1998 to 2016. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.007DOI Listing
February 2019
2 Reads

Biliary Complications Following Pediatric Living Donor Liver Transplantation: Risk Factors, Treatments and Prognosis.

Transplantation 2019 Jan 30. Epub 2019 Jan 30.

Department of Transplant Surgery, Jichi Medical University.

Background: We present retrospective analysis of our 15-year experience with pediatric living donor liver transplantation (LDLT), focusing on the risk factors, treatments and long-term prognosis for post-transplant biliary complications (BCs).

Methods: Between May 2001 and December 2017, 290 LDLTs were performed. The median age was 1. Read More

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http://dx.doi.org/10.1097/TP.0000000000002572DOI Listing
January 2019
2 Reads

Splenic Devascularization Can Replace Splenectomy During Adult Living Donor Liver Transplantation - a historical cohort study.

Transpl Int 2019 Feb 3. Epub 2019 Feb 3.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Simultaneous splenectomy (SSPX) in adult living donor liver transplantation (ALDLT) has definitely beneficial roles such as portal flow modulation in small-for-size graft and correction of hypersplenism-related pancytopenia, and so on, but disastrous complications after SSPX often occur. For the first time, we devised unique and innovative splenic devascularization (SDV) procedure to alleviated untoward effects of SSPX but to maintain its benefits for the indicated patients. From April 2013 to December 2014, 520 recipients underwent ALDLT, and the SSPX and SDV were simultaneously performed in 62 (11. Read More

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http://dx.doi.org/10.1111/tri.13405DOI Listing
February 2019
1 Read
2.599 Impact Factor

Recipient body mass index and infectious complications following liver transplantation.

HPB (Oxford) 2019 Jan 31. Epub 2019 Jan 31.

Department of Hepato-Pancreato-Biliary Surgery & Liver Transplantation, Royal Free Hospital, Pond Street, Hampstead, NW3 2QG, London, UK.

Background: Nutritional problems are common in patients requiring liver transplantation. Recipient obesity or malnutrition are thought to increase postoperative complications. Body mass index (BMI) is commonly used prior to major surgery but its value specifically in liver transplant assessment has not been established. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.01.002DOI Listing
January 2019

Polyethylene Glycol Epirubicin-Loaded Transcatheter Arterial Chemoembolization Procedures Utilizing a Combined Approach with 100 and 200 μm Microspheres: A Promising Alternative to Current Standards.

J Vasc Interv Radiol 2019 Jan 31. Epub 2019 Jan 31.

Vascular and Interventional Radiology Unit, Department of Diagnostic Service, Sapienza University of Rome, Rome, Italy.

Purpose: To report clinical effectiveness, toxicity profile, and prognostic factors of combined 100 μm ± 25 and 200 μm ± 50 epirubicin-loaded polyethylene glycol (PEG) microsphere drug-eluting embolic transcatheter arterial chemoembolization protocol in patients with hepatocellular carcinoma.

Materials And Methods: In this prospective, single-center, single-arm study with 18 months of follow-up, 36 consecutive patients (mean age 69.9 y ± 10. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183164
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http://dx.doi.org/10.1016/j.jvir.2018.10.026DOI Listing
January 2019
2 Reads

Surgical aspects of liver transplantation and domino liver transplantation in maple syrup urine disease: analysis of 15 donor / recipient pairs.

Liver Transpl 2019 Feb 3. Epub 2019 Feb 3.

Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Liver transplantation (LT) has been shown to be a feasible treatment in patients with severe forms of maple syrup urine disease (MSUD). Due to a sufficient extrahepatic enzyme activity in non-MSUD individuals, the organ of MSUD patients can be used as domino graft. We performed a retrospective data collection of all LTs for MSUD carried out at the University Medical Center Hamburg-Eppendorf (2016-2018). Read More

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http://doi.wiley.com/10.1002/lt.25423
Publisher Site
http://dx.doi.org/10.1002/lt.25423DOI Listing
February 2019
3 Reads
4.241 Impact Factor

Three-dimensional versus two-dimensional high-definition laparoscopy in cholecystectomy: a prospective randomized controlled study.

Surg Endosc 2019 Feb 1. Epub 2019 Feb 1.

Department of Abdominal Surgery, University of Helsinki and HUS Helsinki University Hospital, Haartmaninkatu 4, 00029 HUS, Helsinki, Finland.

Background: While 3D laparoscopy increases surgical performance under laboratory conditions, it is unclear whether it improves outcomes in real clinical scenarios. The aim of this trial was to determine whether the 3D laparoscopy can enhance surgical efficacy in laparoscopic cholecystectomy (LCC).

Method: This prospective randomized controlled study was conducted between February 2015 and April 2017 in a day case unit of an academic teaching hospital. Read More

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http://dx.doi.org/10.1007/s00464-019-06666-5DOI Listing
February 2019

Treatment of primary sclerosing cholangitis in children.

World J Hepatol 2019 Jan;11(1):19-36

Department of Pediatrics, University of Utah, Salt Lake City, UT 84113, United States.

Primary sclerosing cholangitis (PSC) is a rare disease of stricturing and destruction of the biliary tree with a complex genetic and environmental etiology. Most patients have co-occurring inflammatory bowel disease. Children generally present with uncomplicated disease, but undergo a variable progression to end-stage liver disease. Read More

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http://dx.doi.org/10.4254/wjh.v11.i1.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354124PMC
January 2019
1 Read

Open versus minimally invasive liver surgery for colorectal liver metastases (LapOpHuva): a prospective randomized controlled trial.

Surg Endosc 2019 Jan 30. Epub 2019 Jan 30.

Department of Liver Surgery and Transplantation, Virgen de la Arrixaca Clinic and University Hospital, IMIB, El Palmar, Murcia, Spain.

Objective: To present surgical and oncological outcomes using a prospective and randomized trial (LapOpHuva, NCT02727179) comparing minimally invasive liver resection (LLR) versus open liver resection (OLR) in patients with colorectal liver metastases (CRLM).

Methods: Between February 2005 and March 2016, 204 selected patients with CRLM were randomized and 193 were included: LLR (n = 96) and OLR (n = 97). The primary endpoint was to compare postoperative morbidity. Read More

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http://dx.doi.org/10.1007/s00464-019-06679-0DOI Listing
January 2019

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

Diabetologia 2019 Jan 31. Epub 2019 Jan 31.

Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL, 33136, USA.

Aims/hypothesis: Patients with autoimmune type 1 diabetes transplanted with pancreatic islets to their liver experience significant improvement in quality of life through better control of blood sugar and enhanced awareness of hypoglycaemia. However, long-term survival and efficacy of the intrahepatic islet transplant are limited owing to liver-specific complications, such as immediate blood-mediated immune reaction, hypoxia, a highly enzymatic and inflammatory environment and locally elevated levels of drugs including immunosuppressive agents, all of which are injurious to islets. This has spurred a search for new islet transplant sites and for innovative ways to achieve long-term graft survival and efficacy without life-long systemic immunosuppression and its complications. Read More

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http://dx.doi.org/10.1007/s00125-019-4814-4DOI Listing
January 2019
1 Read
6.671 Impact Factor

Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

J Clin Med Res 2019 Feb 5;11(2):81-88. Epub 2019 Jan 5.

Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.

Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tract. PSC is strongly associated with inflammatory bowel disease (IBD), mainly with ulcerative colitis, and most PSC patients have underlying IBD. The pathophysiological interactions between IBD and PSC are unclear, although it seems that the patients with IBD and PSC have a distinct phenotype. Read More

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http://dx.doi.org/10.14740/jocmr3680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340671PMC
February 2019
1 Read

Neurological Complications Occurring after Liver Transplantation: Role of Risk Factors, Hepatic Encephalopathy, and Acute (on Chronic) Brain Injury.

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

Sorbonne Université, Brain Liver Pitié-Salpêtrière (BLIPS) Study Group, INSERM, Centre de recherche Saint-Antoine, Maladies métaboliques, biliaires et fibro-inflammatoire du foie, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière-Charles Foix, Service d'hépato-gastroentérologie, Unité de Soins Intensifs d'Hépato-gastroentérologie, Paris, France.

Orthotopic liver transplantation (LT) remains the only way to definitively cure patients with the most severe liver diseases. Since the survival rate is now fairly high, important questions about neurological sequelae or quality of life after LT have emerged. Indeed, LT represents a peculiar situation because up to 30% of patients present with neurological symptoms after LT compared with only 4% after cardiac transplant and 0. Read More

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http://dx.doi.org/10.1002/lt.25420DOI Listing
January 2019
1 Read

A multi-disciplinary approach to pre and post-transplant management of cystic fibrosis associated liver disease.

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Approximately 5 to 10% of patients with cystic fibrosis (CF) will develop advanced liver disease with portal hypertension, representing the 3rd leading cause of death among patients with CF. CF liver disease (CFLD) represents the most significant risk to patient mortality second only to pulmonary or lung transplant complications in patients with CF. Currently there is no medical therapy to treat or reverse CFLD. Read More

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http://dx.doi.org/10.1002/lt.25421DOI Listing
January 2019
1 Read

Liver Transplantation in France.

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

University Paris Diderot, Paris, France.

In France, the main indications for liver transplantation are hepatocellular carcinoma (HCC) and alcoholic cirrhosis. The number of candidates for decompensated hepatitis C virus (HCV)-related cirrhosis has markedly decreased since the advent of direct antiviral agents. Non-alcoholic steatohepatitis represents a lower proportion of candidates as compared to the United States. Read More

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http://dx.doi.org/10.1002/lt.25419DOI Listing
January 2019
2 Reads

Bacterial DNA translocation contributes to systemic inflammation and to minor changes in the clinical outcome of liver transplantation.

Sci Rep 2019 Jan 29;9(1):835. Epub 2019 Jan 29.

Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-Fundación FISABIO), Alicante, Spain.

Bacterial (bact)DNA is an immunogenic product that frequently translocates into the blood in cirrhosis. We evaluated bactDNA clearance in patients undergoing liver transplantation (LT) and its association with inflammation and clinically relevant complications. We prospectively included patients consecutively admitted for LT in a one-year follow-up study. Read More

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http://dx.doi.org/10.1038/s41598-018-36904-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351615PMC
January 2019

Ectopic Balloon Device Placement to Correct the Positional Hepatic Venous Outflow Obstruction in Liver Transplantation.

Exp Clin Transplant 2019 Jan 29. Epub 2019 Jan 29.

From Inonu University Liver Transplantation Institute, Malatya, Turkey.

Objectives: Hepatic vein outflow obstruction in liver transplantation can lead to graft or patient loss. We used an intrauterine balloon to overcome this complication in 13 liver transplant recipients. Here, we report the results of these cases; our report, as far as we know, involves the highest number of patients on this issue. Read More

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http://dx.doi.org/10.6002/ect.2018.0125DOI Listing
January 2019
0.798 Impact Factor

The devil is in the detail: current management of perioperative surgical complications after liver transplantation.

Curr Opin Organ Transplant 2019 Jan 28. Epub 2019 Jan 28.

Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Despite advances in the field, perioperative morbidity is common after liver transplantation. This review examines the current literature to provide up-to-date management of common surgical complications associated with liver transplantation.

Recent Findings: Research focuses on problems with anastomoses of the vena cava, portal vein, hepatic artery, and bile ducts. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000616DOI Listing
January 2019
1 Read

Correcting micronutrient deficiencies before sleeve gastrectomy may be useful in preventing early postoperative micronutrient deficiencies.

Int J Vitam Nutr Res 2019 Jan 29:1-7. Epub 2019 Jan 29.

6 Université Côte d'Azur, Nice, France.

Micronutrient deficiencies (MD) shortly after sleeve gastrectomy (SG) are frequent and patients with obesity often show MD preoperatively. Our aim was to assess whether the correction of MD before SG could play a role in preventing early postoperative MD. Eighty patients (58 females, 22 males) who underwent SG were evaluated retrospectively. Read More

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http://dx.doi.org/10.1024/0300-9831/a000532DOI Listing
January 2019

The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study.

BMC Gastroenterol 2019 Jan 28;19(1):18. Epub 2019 Jan 28.

Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London, UK.

Background: Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

Methods: We conducted a population-based study of ALF patients hospitalized between 2009 and 2013 from the Thai Nationwide Hospital Admission database, which comprises 76% of all admissions from 858 hospitals across 77 provinces in Thailand. Read More

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http://dx.doi.org/10.1186/s12876-019-0935-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348628PMC
January 2019
2 Reads
2.365 Impact Factor

[Risk factors for deterioration of liver functions after successful kidney transplantation].

Orv Hetil 2019 Feb;160(5):186-190

Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.

Introduction: Increase of liver function is one of the most common complications after kidney transplantation due to the use of immunosuppressive therapy and hyperlipidemia in addition to hepatitis C virus (HCV) infection.

Method: Following the selection criteria (n = 59), the study is based on applied immunosuppressive therapy, baseline data of patients, further correlation between HCV and liver function deterioration. Patients were subjected to fasting laboratory examination to monitor serum electrolytes, uric acid and albumin levels. Read More

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https://www.akademiai.com/doi/10.1556/650.2019.31257
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http://dx.doi.org/10.1556/650.2019.31257DOI Listing
February 2019
2 Reads

Auxiliary Liver Transplantation as a Transient Treatment for Acute Liver Failure: Two Cases.

GE Port J Gastroenterol 2018 Dec 7;26(1):54-58. Epub 2018 Mar 7.

Adult and Paediatric Liver Transplantation Unit, Coimbra University and Hospital Centre, Coimbra, Portugal.

Introduction: Acute liver failure is an uncommon condition associated with a high mortality. Most patients do not survive without liver transplantation. In the last decades, auxiliary liver transplantation has emerged as a therapeutic option. Read More

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http://dx.doi.org/10.1159/000487155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341369PMC
December 2018
1 Read

Long Term Survival in Visceral Transplant Recipients in the New Era: A Single Center Experience.

Am J Transplant 2019 Jan 23. Epub 2019 Jan 23.

MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC.

There is a paucity of data on long-term outcomes following visceral transplantation in the contemporary era. This is a single-center retrospective analysis of all visceral allograft recipients who underwent transplant between November 2003 and December 2013 with at least 3-year follow up data. Clinical data from a prospectively maintained database was used to assess outcomes including patient and graft survival. Read More

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http://dx.doi.org/10.1111/ajt.15269DOI Listing
January 2019
3 Reads

Systematic Endoscopy 5 Years After Sleeve Gastrectomy Results in a High Rate of Barrett's Esophagus: Results of a Multicenter Study.

Obes Surg 2019 Jan 21. Epub 2019 Jan 21.

Université Côte d'Azur, Nice, France.

Background: Recent evidence has indicated an increased risk of Barrett's esophagus (BE) in the long term after sleeve gastrectomy (SG).

Aim: The aim of the study is to investigate the spectrum of gastroesophageal reflux disease (GERD) symptoms as well as the prevalence of BE, at minimum 5 years after SG in patients who underwent SG in different bariatric centers of two countries: France and Italy.

Patients And Methods: Five high volume outpatient centers dedicated to bariatric surgery that routinely perform upper GI endoscopy before any bariatric procedures were invited to participate in the study. Read More

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http://dx.doi.org/10.1007/s11695-019-03704-yDOI Listing
January 2019
4 Reads

Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review.

Respir Med 2019 Jan 12;146:81-86. Epub 2018 Dec 12.

Avera McKennan Hospital & University Health Center: Avera Medical Group Transplant & Liver Surgery, Sioux Falls, SD, USA.

Pulmonary infections are frequent complications in abdominal solid-organ transplantation (aSOT) which may threaten patient and allograft survival. Accurate diagnosis and treatment of pulmonary infections in this population can be challenging. Immunosuppressive therapy not only increases the risk of acquiring opportunistic and non-opportunistic infections, but it also impairs the inflammatory responses associated with microbial invasion which in an otherwise normal host produce clinical and radiologic responses that allow for early identification of the offending pathogen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183038
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http://dx.doi.org/10.1016/j.rmed.2018.12.002DOI Listing
January 2019
3 Reads

Organ transplantation and gut microbiota: current reviews and future challenges.

Am J Transl Res 2018 15;10(11):3330-3344. Epub 2018 Nov 15.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology 13 Hangkong Road, Wuhan 430030, China.

Organ transplantation is often the only effective treatment for patients with end-stage diseases, such as heart, liver, kidney and small bowel failure and is carried out frequently worldwide. Still the post-transplantation complications remain health- and life-threatening outcome that needed to be resolved. With the rapid development of molecular technologies in recent years, more and more researchers realize that the gut microbiota may play a critical role in human diseases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291689PMC
November 2018
6 Reads

Surgical Technique Notes of Arterial Vascular Reconstruction During Kidney Transplantation: Personal Experience and Literature Review.

Transplant Proc 2019 Jan - Feb;51(1):128-131. Epub 2018 Jun 28.

General Surgery and Organ Transplantation Unit, Department of Surgery, Sapienza University of Rome, Rome, Italy.

Background: Arterial vascular anomalies in patients undergoing kidney transplantation (KT) are correlated with a higher incidence of early surgical complications, potentially causing graft loss. Arterial reconstruction allows patients to overcome these surgical challenges, thus minimizing the risk of poor outcomes. The aim of the present study is to retrospectively investigate the safety and effectiveness of the multiple arterial reconstruction technique with a Teflon patch in case of an unavailable aortic patch: to do so, surgical complications, graft function, and patient survival were evaluated. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.072DOI Listing
June 2018
2 Reads