31,365 results match your criteria Liver Transplantation Complications


ABO-Incompatible Liver Transplantation - A Review of the Historical Background and Results.

Int Rev Immunol 2019 Apr 23:1-11. Epub 2019 Apr 23.

a Transplant Institute, Sahlgrenska University Hospital, Sahlgrenska Academy , Gothenburg , Sweden.

ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive protocols which have made the outcome after living donor (LD) ABOi LT equivalent to that achieved with LD ABO-compatible (ABOc). The experience of deceased donor (DD) ABOi LT is however still limited. Read More

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http://dx.doi.org/10.1080/08830185.2019.1601720DOI Listing

Hepatic artery reconstruction with interposition of donor's right gastroepiploic artery graft in pediatric living donor liver transplantation for metabolic disease.

Pediatr Transplant 2019 Apr 23:e13418. Epub 2019 Apr 23.

Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: We introduce the indications, technique, results of our experience using donor's RGEA as interposition vessel to solve hepatic artery reconstruction problems in P-LDLT.

Methods: A retrospective analysis of P-LDLT for children with metabolic diseases from June 2013 to November 2018 in our center was carried out. The arterial conditions, reconstruction methods, and prognosis were analyzed. Read More

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http://dx.doi.org/10.1111/petr.13418DOI Listing

Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

Pediatr Transplant 2019 Apr 23:e13420. Epub 2019 Apr 23.

Department of Clinical Hematology, Royal Children's Hospital, Parkville, Victoria, Australia.

Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children post-liver transplant, with comparison to our institution's experience. Read More

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http://dx.doi.org/10.1111/petr.13420DOI Listing

Portal Vein Stent Placement in Living-donor Liver Transplantation: A Single-center Experience.

Transplant Proc 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Introduction: Portal vein thrombosis (PVT) and portal vein stenosis (PVS) are rare complications after liver transplantation that can lead to graft failure and patient death.

Material And Methods: The aim of this study was to evaluate the effect of interventional treatment for PVT and PVS occlusion after liver transplantation. Follow-up data of 7 patients who underwent stent replacement for PVT and/or PVS were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183170
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http://dx.doi.org/10.1016/j.transproceed.2019.01.123DOI Listing
April 2019
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Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview.

Int J Mol Sci 2019 Apr 20;20(8). Epub 2019 Apr 20.

Department of Clinical and Molecular Medicine, University of Catania, Catania 95100, Italy.

Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in developed countries but its diffusion is currently also emerging in Asian countries, in South America and in other developing countries. It is progressively becoming one of the main diseases responsible for hepatic insufficiency, hepatocarcinoma and the need for orthotopic liver transplantation. NAFLD is linked with metabolic syndrome in a close and bidirectional relationship. Read More

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https://www.mdpi.com/1422-0067/20/8/1948
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http://dx.doi.org/10.3390/ijms20081948DOI Listing
April 2019
1 Read

Long-term results of liver transplantation for polycystic liver disease: Single-center experience in China.

Exp Ther Med 2019 May 27;17(5):4183-4189. Epub 2019 Mar 27.

Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China.

The aim of the present study was to explore the indications for and safety of orthotopic liver transplantation for polycystic liver disease (PLD). Orthotopic liver transplantation in 11 patients with PLD between May 2004 and September 2013 was retrospectively analyzed. Patient epidemiological, clinical and follow-up data were collected. Read More

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http://dx.doi.org/10.3892/etm.2019.7449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468458PMC

Hepatobiliary scintigraphy in the study of complications in adult patients after liver transplant. Description of the experience.

Rev Esp Med Nucl Imagen Mol 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Medicina Nuclear, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia. Electronic address:

Objective: To show the experience of the use of hepatobiliary scintigraphy in patients with suspected complications after liver transplantation in a high complexity centre.

Material And Method: Retrospective, observational and descriptive study. All consecutive adult patients with liver transplantation between January 2013 and February 2018 were included, with one or more hepatobiliary scintigraphy during the early or late postoperative period. Read More

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http://dx.doi.org/10.1016/j.remn.2019.02.006DOI Listing

Outcome of kidney transplantation from young pediatric donors (aged less than 6 years) to young size-matched recipients.

J Pediatr Urol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Nephrology, University Hospital Vall d'Hebron, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain; School of Medicine, Universitat Autonoma de Barcelona, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain.

Introduction: Pediatric donation is underutilized because of presumed increased risk of vascular thrombosis (VT) and graft loss. Using young pediatric donors (YPDs) for young pediatric recipients (YPRs) is suggested to be even at greater risk and therefore precluded in many centers. The aim of this study was to analyze the outcome of kidney transplantation (KT) from YPD to age-matched YPR. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.015DOI Listing
March 2019
2 Reads

Feasibility and safety of liver transplantation or resection after transarterial radioembolization with Yttrium-90 for unresectable hepatocellular carcinoma.

HPB (Oxford) 2019 Apr 17. Epub 2019 Apr 17.

Department of Visceral Surgery, Lausanne University Hospital CHUV, Switzerland; Department of Liver Surgery, Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: The benefit of transarterial radioembolization (TARE) in patients with unresectable hepatocellular carcinoma (HCC) is increasingly evidenced. However, data on outcome of liver transplantation or resection after TARE remain scarce. This study aimed to assess the safety and feasibility of surgery after TARE in patients with unresectable HCC. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.360DOI Listing

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.

Int Immunopharmacol 2019 Apr 16;72:224-234. Epub 2019 Apr 16.

Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address:

Fatty liver is used for transplantation due to organ shortage, but prone to cause complications like ischemia-reperfusion injury (IRI). NKT cells as a bridge between innate and adaptive immunity were reported to infiltrate the liver at the early phase of IRI induced in normal liver. However, the localization mechanism of NKT cells is not precise, and the role of NKT cells in fatty liver IRI is poorly understood. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.021DOI Listing

Endotipsitis as an indication for pediatric liver transplantation.

Transpl Infect Dis 2019 Apr 19:e13097. Epub 2019 Apr 19.

Hepatobiliary Surgery and Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.

Endotipsitis is a rare but severe complication of transjugular intrahepatic portosystemic shunt (TIPS), a device widely used to treat portal hypertension in adults, but sparsely used in children. We report a case of endotipsitis in a 3-year-old child affected of biliary atresia. She underwent a Kasai procedure at 3 months of age but, although the bile flow was restored, she presented upper gastrointestinal bleeding due to portal hypertension 1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tid.13097
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http://dx.doi.org/10.1111/tid.13097DOI Listing
April 2019
2 Reads

Invited Commentary to "The Gastric Migration Crisis in Obesity Surgery".

Obes Surg 2019 Apr 17. Epub 2019 Apr 17.

Digestive Surgery Unit, Centre Hospitalier Universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, France.

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http://link.springer.com/10.1007/s11695-019-03873-w
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http://dx.doi.org/10.1007/s11695-019-03873-wDOI Listing
April 2019
1 Read

Safety and outcomes of pre-operative portal vein embolization using N-butyl cyanoacrylate (Glue) in hepatobiliary malignancies: A single center retrospective analysis.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):40-46

Department of Liver Transplantation and Hepato Pancreatico Biliary Surgery, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India.

Aims And Objectives: To evaluate the outcome of preoperative portal vein embolization (PVE) using N-butyl cyanoacrylate (NBCA) for change in future liver remnant (FLR) volume, biochemical changes, and procedure-related complications. The factors affecting FLR hypertrophy and the rate of resection was also evaluated for this cohort.

Materials And Methods: From 2012 to 2017, PVE utilizing NBCA mixed with lipiodol (1:4) was performed using percutaneous approach in 28 patients with hepatobiliary malignancies with low FLR. Read More

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http://www.ijri.org/text.asp?2019/29/1/40/255238
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http://dx.doi.org/10.4103/ijri.IJRI_454_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467029PMC
April 2019
2 Reads

PREOPERATIVE ASSESSMENT OF MUSCLE MASS USING COMPUTERIZED TOMOGRAPHY SCANS TO PREDICT OUTCOMES FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION.

Transplantation 2019 Apr 10. Epub 2019 Apr 10.

Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.

Background: Sarcopenia is an established risk factor predicting survival in chronically ill and trauma patients. We herein examine the assessment and clinical implication of sarcopenia in liver transplantation (LT).

Methods: Computerized tomography (CT) scans from 172 patients waitlisted for LT were analysed applying six morphometric muscle scores, including two density indices [Psoas Density (PD), Skeletal Muscle Density (SMD)] and four scores based on muscle area [total psoas area (TPA), psoas muscle index (PMI), skeletal muscle area (SMA), skeletal muscle index (SMI)]. Read More

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http://dx.doi.org/10.1097/TP.0000000000002759DOI Listing
April 2019
7 Reads

A Novel Mutation in Chronic Granulomatous Disease: Treating the Family, Not Just the Patient.

Front Pediatr 2019 28;7:107. Epub 2019 Mar 28.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States.

Chronic Granulomatous Disease (CGD) is caused by genetic defects in the phagocyte NADPH oxidase leading to potentially severe infections with catalase positive micro-organisms. With the innate immune system being affected this disease usually presents before the age of 5 years with infections involving the skin, lung, liver or lymphnodes. Infections with specific catalase positive organisms, especially and prompt a workup for CGD in affected patients. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00107/
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http://dx.doi.org/10.3389/fped.2019.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447646PMC
March 2019
3 Reads

Optimal Biliary Drainage for Patients with Biliary Anastomotic Strictures After Right-Lobe Living Donor Liver Transplantation.

Liver Transpl 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

Background/aims: There are usually two bile duct anastomosis sites, namely, the right anterior segmental duct (RASD) and the right posterior segmental duct (RPSD), in right lobe (RL) living donor liver transplantation (LDLT). This study aimed to evaluate the optimal treatment for biliary strictures following RL-LDLT with respect to unilateral or bilateral drainage technique.

Methods: From January 2005 to December 2017, 883 patients at Seoul National University Hospital underwent RL-LDLT. Read More

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http://dx.doi.org/10.1002/lt.25472DOI Listing

Mesenchymal Stem Cells as a Salvage Treatment for Severe Refractory Graft-vs-Host Disease in Children After Bone Marrow Transplantation.

Transplant Proc 2019 Apr 8;51(3):880-889. Epub 2019 Jan 8.

Department of Transplantation, Jagiellonian University Medical College, Krakow, Poland.

Application of mesenchymal stem cells (MSC) enables a novel approach to the therapy of graft- vs-host disease (GVHD) after hematopoietic stem cell transplantation. Herein we present our preliminary experience with the use of allogeneic bone marrow‒derived MSC in 9 pediatric patients after hematopoietic transplantation complicated by severe acute or chronic GVHD (aGVHD, cGVHD) resistant to steroids and second-line immunosuppressants. The MSC therapy was applied concurrently with immunosuppressive treatment in 5 patients as a single infusion, in four patients as 2-6 infusions. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.023DOI Listing
April 2019
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Value of Model for End-Stage Liver Disease-Serum Sodium Scores in Predicting Complication Severity Grades After Liver Transplantation for Acute-on-chronic Liver Failure.

Authors:
Q-K Zhang M-L Wang

Transplant Proc 2019 Apr 9;51(3):833-841. Epub 2019 Jan 9.

General Surgical Center, Beijing You-An Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Preoperative evaluation is extremely important for patients undergoing liver transplantation (LT) for acute-on-chronic liver failure (ACLF). It is unclear that whether preoperative Model for End-Stage Liver Disease-Serum Sodium (MELD-Na) score has a decisive effect on the complication grade after LF for ACLF. This study is aimed to explore the value of preoperative MELD-Na scores in predicting complication severity grades post LT for ACLF. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.027DOI Listing
April 2019
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Vascular and Biliary Complications Following Deceased Donor Liver Transplantation: A Meta-analysis.

Transplant Proc 2019 Apr 9;51(3):823-832. Epub 2019 Jan 9.

Institute of Hepatobiliary Diseases, Transplant Center, Hubei Key Laboratory of Medical Technology on Transplantation, Zhongnan Hospital, Wuhan University, Wuhan, China; Transplantation Medicine Engineering and Technology Research Center, National Health Commission, the 3rd Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Objective: To assess biliary and vascular complications after liver transplantations (LTs) sourced from deceased donors.

Methods: This study reviewed potentially relevant English-language articles gathered from PubMed and Medline published from 2012 to 2017. One additional study was carried out using our institution's database for articles published from 2013 to 2017. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.11.010DOI Listing

Liver Transplantation for Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome: A Propensity-score Matched Long-term Survival of the Scientific Registry of Transplant Recipients Dataset.

Transplant Proc 2019 Apr 9;51(3):805-812. Epub 2019 Jan 9.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address:

Background: Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a life-threatening form of pre-eclampsia/eclampsia, with liver transplantation being the life-saving option for treatment for those who develop severe hepatic complications.

Methods: We retrospectively analyzed data from the Scientific Registry of Transplant Recipients (SRTR) through October 1, 1987, to December 31, 2014. Forty patients were listed for liver transplantation, with 18 patients finally receiving their transplant. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.032DOI Listing
April 2019
1 Read

Effect of Liver Disease Etiology on ROTEM Profiles in Patients Undergoing Liver Transplantation.

Transplant Proc 2019 Apr 9;51(3):783-789. Epub 2019 Jan 9.

Department of Anaesthetics, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.

Background: Coagulation abnormalities in liver transplant patients are complex and may be related to the underlying liver disease. We evaluated the effects of disease etiology on whole-blood rotational thromboelastometry (ROTEM; Pentapharm GmbH, Munich, Germany) profile and association with thrombotic complications following liver transplantation.

Methods: Analysis of perioperative data from patients undergoing liver transplantation between January 1, 2012 and December 31, 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183131
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http://dx.doi.org/10.1016/j.transproceed.2018.12.030DOI Listing
April 2019
3 Reads

Ischemic Cholangiopathy: Insight From an Explant Liver Allograft Affected by Severe Post-transplant Hypoxemia Due to Hepatopulmonary Syndrome: A Case Report.

Transplant Proc 2019 Apr 9;51(3):1002-1005. Epub 2019 Jan 9.

Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai, India.

Increased biliary complications in hepatopulmonary syndrome (HPS) have been hypothesized due to post-transplant hypoxemia. Supporting this hypothesis, we report histopathological findings from an explant liver allograft where the recipient suffered severe and prolonged post-operative hypoxemia. A 4-year-old child underwent liver transplantation (LT) for decompensated chronic liver disease complicated by severe HPS. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.11.009DOI Listing

Influence of Type 2 Diabetes Mellitus and Preoperative Hemoglobin A1c Levels on Outcomes of Liver Transplantation.

Hepatol Commun 2019 Apr 20;3(4):574-586. Epub 2019 Feb 20.

Division of Gastroenterology, Hepatology, and Endoscopy Brigham and Women's Hospital Boston MA.

Liver transplant centers often establish hemoglobin A1c (HbA1C) criteria for candidates with type 2 diabetes mellitus (T2DM) based on data from other surgical specialties showing worse outcomes in patients with poor glycemic control. However, because of the reduced reliability of HbA1C in cirrhosis, it is unclear whether pretransplant HbA1C values are predictive of postoperative complications in liver recipients. We retrospectively examined the association between preoperative HbA1C and postoperative outcomes in 173 consecutive patients who underwent liver transplantation at the University of Cincinnati Medical Center between August 2012 and March 2015. Read More

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http://dx.doi.org/10.1002/hep4.1323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442696PMC
April 2019
1 Read

Living Donor Liver Transplantation: Preoperative Planning and Postoperative Complications.

AJR Am J Roentgenol 2019 Apr 11:1-12. Epub 2019 Apr 11.

7 Department of Radiology, Mayo Clinic, Rochester, MN.

Objective: The purposes of this article are to highlight the similarities and differences in workup and work flow across multiple institutions in the preoperative imaging assessment of liver donors; to lay the foundation for developing consensus guidelines; to illustrate clinically relevant anatomic variants; to introduce a standardized reporting template; and to review postprocessing work flow and postoperative donor complications.

Conclusion: Further investigation and consensus are needed to determine protocols, time intervals, and duration of follow-up of liver donors that are cost-effective and clinically relevant. Read More

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http://dx.doi.org/10.2214/AJR.18.21064DOI Listing
April 2019
1 Read
2.731 Impact Factor

Determination of risk factors affecting mortality in patients with gastrointestinal perforation after pediatric liver transplantation.

Pediatr Transplant 2019 Apr 11:e13415. Epub 2019 Apr 11.

Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya, Turkey.

Gastrointestinal perforation (GIP) is one of the most serious complications occurring after liver transplantation (LT), especially in pediatric patients. This study aimed to determine the risk factors affecting mortality in pediatric patients with GIP after LT. GIP developed in 37 (10%) of 370 pediatric patients who underwent LT at our institute. Read More

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http://dx.doi.org/10.1111/petr.13415DOI Listing
April 2019
1.630 Impact Factor

The Perme scale score as a predictor of functional status and complications after discharge from the intensive care unit in patients undergoing liver transplantation.

Rev Bras Ter Intensiva 2019 Jan-Mar;31(1):57-62

Curso de Fisioterapia e Programa de Pós-Graduação em Saúde e Desenvolvimento Humano, Universidade La Salle - Canoas (RS), Brasil.

Objective: To assess the Perme mobility scale score as a predictor of functional status and complications in the postoperative period in patients undergoing liver transplantation.

Methods: The sample consisted of 30 patients who underwent liver transplantation. The patients were evaluated at two time points to determine their perception of pain, degree of dyspnea, peripheral muscle strength, and functional status according to the Perme scale. Read More

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http://dx.doi.org/10.5935/0103-507X.20190016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443309PMC

Propensity score-matched analysis of early outcomes after laparoscopic-assisted versus open pancreaticoduodenectomy.

ANZ J Surg 2019 Apr 9. Epub 2019 Apr 9.

Division of Hepatopancreaticobiliary Surgery and Liver Transplantation, Department of Surgery, National University Health System, Singapore.

Background: Minimally invasive pancreaticoduodenectomy (PD) is a feasible option for periampullary tumours. However, it remains a complex procedure with no proven advantages over open PD (OPD). The aim of the study was to compare the outcomes between laparoscopic-assisted PD (LAPD) and OPD using a propensity score-matched analysis. Read More

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http://dx.doi.org/10.1111/ans.15124DOI Listing
April 2019
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Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Development and Psychometric Testing of Liver Transplant Therapeutic Adherence Questionnaire in a Triphasic Mixed-Method Study.

Prog Transplant 2019 Apr 8:1526924819835824. Epub 2019 Apr 8.

4 Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Due to the high nonadherence rate to posttransplant regimen and medical indications among liver transplant recipients, systematic patient-centered interventions are needed to improve the medium- and long-term graft and patient survival outcomes.

Objective: The aim of this study was to develop and test the psychometric properties of Liver Transplant Therapeutic Adherence Questionnaire.

Design: A mixed-method instrument design was conducted in 3 phases: (1) initial item collection was generated by inductive content analysis on internationally available resources, (2) item screening was carried out by a 3-member committee and 25 domain experts including nurses and physicians aiming to establish content validity, and (3) data were collected from 247 liver transplant recipients in May 2016 for psychometric testing. Read More

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http://dx.doi.org/10.1177/1526924819835824DOI Listing

Efficacy of Nasobiliary Tubes and Biliary Stents in Management of Patients with Bile Leak after Liver Transplantation: A Systematic Review.

Clin Endosc 2019 Mar 29;52(2):159-167. Epub 2019 Mar 29.

Division of Gastroenterology, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Background/aims: Bile leak is one of the most common complications of liver transplantation. The treatment options for bile leaks include conservative management, surgical re-intervention, percutaneous drainage and endoscopic drainage. We aimed to perform a systematic review to identify the efficacy of endoscopic treatment in the resolution of post-transplant bile leaks. Read More

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http://dx.doi.org/10.5946/ce.2018.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453846PMC
March 2019
1 Read

Impact of early remote organ dysfunction on long-term survival after liver transplantation.

Clin Res Hepatol Gastroenterol 2019 Apr 3. Epub 2019 Apr 3.

Hepato-pancreato-biliary surgery and liver transplantation, hopitaux universitaires de Strasbourg, hopital de Hautepierre, 1 avenue Molière, 67000 Strasbourg, France; Laboratoire ICube, UMR7357, university of Strasbourg, 300, boulevard Sébastien Brandt, 67200 Illkirch-Graffenstaden, France. Electronic address:

Background: Attention is focused on graft function although extrahepatic organ dysfunction often occurs. Renal failure, cardiovascular events and sepsis have individually shown a significant impact on short- and long-term outcomes. The aim of the study was to identify how extrahepatic organ dysfunction (EROD) and allograft dysfunction (EAD) may be associated and their relative impact on long-term survival. Read More

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http://dx.doi.org/10.1016/j.clinre.2019.02.016DOI Listing
April 2019
1 Read

Outcomes of adult patients adopting small-for-size grafts in living donor liver transplantation: A systematic review and meta-analysis.

Hepatobiliary Pancreat Dis Int 2019 Mar 29. Epub 2019 Mar 29.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Background: Small-for-size graft (SFSG) has emerged as one of the very contentions in adult-to-adult living donor liver transplantation (LDLT) as a certain graft size is related to recipients' prognosis. Graft-to-recipient weight ratio (GRWR) ≥0.8% was considered as a threshold to conduct LDLT. Read More

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http://dx.doi.org/10.1016/j.hbpd.2019.03.007DOI Listing
March 2019
2 Reads

Short- and Long-Term Outcomes of Liver Resection for Intrahepatic Cholangiocarcinoma Associated with the Metabolic Syndrome.

World J Surg 2019 Apr 4. Epub 2019 Apr 4.

Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Background: While the metabolic syndrome (MS) is being recognized as an important risk factor for intrahepatic cholangiocarcinoma (ICC), the outcomes of liver resection in this context remain poorly described. This study aims to report the short- and long-term results of hepatectomy for patients with MS as risk factor for the development of ICC (MS+).

Methods: All patients undergoing hepatectomy for ICC between 2000 and 2016 at a single center were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00268-019-04996-yDOI Listing
April 2019
4 Reads

The Value of Liver Transplantation for Methylmalonic Acidemia.

Front Pediatr 2019 21;7:87. Epub 2019 Mar 21.

Intensive Care Unit, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

MMA is a rare autosomal recessive disorder with the manifestation of recurrent and severe episodes of acute metabolic decompensation or a variety of long-term complications that require timely treatment. While conventional long-term medical and dietary management cannot prevent rapid progression of conditions in patients with severe complications, LT, or CKLT has become an option. We reviewed the literature for MMA patients undergoing LT/CKLT published since 2006, and data on metabolic decompensation status, protein dietary, neurological damage, renal insufficiency, and developmental delay before and after transplantations were compared to evaluate the clinical value of the procedure in the treatment of MMA. Read More

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http://dx.doi.org/10.3389/fped.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437036PMC
March 2019
5 Reads

The Liver in Sickle Cell Disease.

Clin Liver Dis 2019 May 21;23(2):177-189. Epub 2019 Feb 21.

Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK. Electronic address:

Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. Some patients develop cirrhosis that may progress to end-stage liver failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10893261183010
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http://dx.doi.org/10.1016/j.cld.2018.12.002DOI Listing
May 2019
3 Reads

Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.

Transpl Immunol 2019 Apr 1. Epub 2019 Apr 1.

Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address:

Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5. Read More

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http://dx.doi.org/10.1016/j.trim.2019.03.004DOI Listing
April 2019
7 Reads

Postoperative Complications of Plastic and Reconstructive Surgery in Solid Organ Transplant Recipients.

J Craniofac Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Plastic and Reconstructive Surgery, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.

Introduction: As the number of organ transplants and the survival rate increase, solid organ transplant patients will need more plastic and reconstructive surgery. However, such patients take immunosuppressants, including prednisone, which makes wound healing slower and plastic surgeons more hesitate to operate. In this study, we examined postoperative complications of organ transplant patients who have undergone plastic and reconstructive surgery. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005511DOI Listing
March 2019
4 Reads

Perioperative hemostatic management in the cirrhotic patient: a position paper on the behalf of the Liver Intensive Care Group of Europe (LICAGE).

Minerva Anestesiol 2019 Apr 2. Epub 2019 Apr 2.

Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, The Netherlands.

Recent data demonstrated that amongst patients undergoing elective surgery the prevalence of cirrhosis is 0.8% equating to approximately 25 million cirrhotic patients undergoing surgery each year worldwide. Overall, the presence of cirrhosis is independently associated with 47% increased risk of postoperative complications and over two and a half increased risk of in-hospital mortality in patients undergoing elective surgery. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13468-2DOI Listing
April 2019
2 Reads

A Review on the Management of Biliary Complications after Orthotopic Liver Transplantation.

J Clin Transl Hepatol 2019 Mar 3;7(1):61-71. Epub 2018 Dec 3.

Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA.

Orthotopic liver transplantation is the definitive treatment for end-stage liver disease and hepatocellular carcinomas. Biliary complications are the most common complications seen after transplantation, with an incidence of 10-25%. These complications are seen both in deceased donor liver transplant and living donor liver transplant. Read More

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http://dx.doi.org/10.14218/JCTH.2018.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441650PMC
March 2019
2 Reads

Surgical and oncological outcomes of hepatic resection for BCLC-B hepatocellular carcinoma: a retrospective multicenter analysis among 474 consecutive cases.

Updates Surg 2019 Apr 2. Epub 2019 Apr 2.

Department of General Surgery and Transplantation, Niguarda Ca' Granda Hospital, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

The Barcelona clinic liver cancer (BCLC) algorithm is the most widely accepted staging system form hepatocellular carcinoma (HCC). Liver resection is traditionally proposed to early stage HCC (BCLC-0/A), even if recent reports have shown that surgical resection could provide a safe and effective treatment also for intermediate-stage HCC (BCLC-B). In this study, we focused on surgical and oncological outcomes of hepatic resection in BLCB-B patients. Read More

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http://dx.doi.org/10.1007/s13304-019-00649-wDOI Listing
April 2019
8 Reads

A 'Back-to-base' Experience of Human Normothermic Ex Situ Liver Perfusion: Does the chill kill?

Liver Transpl 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgery, University of Alberta, Edmonton, Canada.

Rationale: Normothermic machine perfusion (NMP) has been shown to protect livers from injury between procurement and transplantation in a randomized controlled trial, where the machine was transported to and from the donor center. The aim of this study was to determine whether an alternative, more practical 'Back-to-base' approach after initial static cold storage (SCS) would compromise beneficial outcomes.

Methods: Between February 2015 and June 2018, a non-randomized pilot study was performed at a single site. Read More

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http://dx.doi.org/10.1002/lt.25464DOI Listing
April 2019
6 Reads

Pressure gradients, laboratory changes, and outcomes with transjugular intrahepatic portosystemic shunts in pediatric portal hypertension.

Pediatr Transplant 2019 Apr 1:e13387. Epub 2019 Apr 1.

Division of Gastroenterology and Hepatology, Department of Pediatrics, University of Washington School of Medicine/Seattle Children's Hospital, Seattle, Washington.

Introduction: Indications for TIPS are well described in adults and involve complications of PHTN. Complications from PHTN are associated with PSG of > 12 mm Hg in adults. It is unclear if these parameters apply to children with PHTN. Read More

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http://dx.doi.org/10.1111/petr.13387DOI Listing
April 2019
3 Reads

Current and promising therapy for primary biliary cholangitis.

Expert Opin Pharmacother 2019 Apr 1:1-7. Epub 2019 Apr 1.

a Mayo Clinic , Division of Gastroenterology and Hepatology , Rochester , MN , USA.

Introduction: Primary biliary cholangitis is a chronic, cholestatic liver disease that may progress to cirrhosis with complications of end-stage liver disease. Approved treatment options include ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) but novel therapies are being investigated. Areas covered: In this review, the authors describe the current pharmacotherapy for the treatment of primary biliary cholangitis (PBC) and for management of side effects such as pruritus and fatigue based on the currently available literature. Read More

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http://dx.doi.org/10.1080/14656566.2019.1601701DOI Listing
April 2019
9 Reads

Successful recanalization of acute extensive portal vein thrombosis by aspiration thrombectomy and thrombolysis via an operatively placed mesenteric catheter: a case report.

BJR Case Rep 2018 Dec 21;4(4):20180024. Epub 2018 May 21.

Department of Radiology, Tokyo Medical University Hospital, Tokyo, Japan.

Portal vein thrombosis (PVT) after hepatobiliary surgery is rare but can cause lethal and severe complications. If early diagnosis and recanalization can be achieved, the PVT is expected to be eliminated. A 70-year-old male was diagnosed as having hepatocellular carcinoma occupying the right lobe of the liver. Read More

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http://dx.doi.org/10.1259/bjrcr.20180022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438407PMC
December 2018
1 Read

Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries.

Langenbecks Arch Surg 2019 Mar 30. Epub 2019 Mar 30.

Section for Transplant Surgery, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.

Background: Iatrogenic injuries to vital structures of the liver and posthepatectomy liver failure are associated with high mortality. The current donor situation in Norway allows liver transplantation of patients beyond conventional criteria.

Methods: From 1984 to 2017, a total of 1510 liver transplantations were performed. Read More

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http://dx.doi.org/10.1007/s00423-019-01780-3DOI Listing
March 2019
1 Read
2.160 Impact Factor

Abdominal surgery in patients with idiopathic noncirrhotic portal hypertension: a multicenter retrospective study.

Hepatology 2019 Mar 29. Epub 2019 Mar 29.

Service d'Hépatologie, Centre de Référence des Maladies Vasculaires du Foie, DHU Unity, Pôle des Maladies de l'Appareil Digestif, Hôpital Beaujon, AP-HP, Clichy, France.

In patients with idiopathic noncirrhotic portal hypertension (INCPH), data on morbi-mortality of abdominal surgery are scarce We retrospectively analyzed the charts of patients with INCPH undergoing abdominal surgery within the VALDIG network. Forty-four patients with biopsy-proven INCPH were included. Twenty-five (57%) patients had ≥1 extrahepatic conditions related with INCPH and 16 (36%) had a history of ascites. Read More

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http://dx.doi.org/10.1002/hep.30628DOI Listing
March 2019
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Health-related Quality of Life in Liver Transplantation: Another Step Forward.

Transpl Int 2019 Mar 29. Epub 2019 Mar 29.

Multivisceral Transplant Unit, Gastroenterology, Dept. of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.

In the field of liver transplantation (LT), satisfactory results have been achieved in recent years in terms of graft and patient survival, but improving patients' health-related quality of life (HRQoL) remains an issue. It is well known that the HRQoL of patients with end-stage liver disease is impaired due to the life-threatening complications of portal hypertension, frequent hospitalizations, and limitations on their social life. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/tri.13435DOI Listing
March 2019
2 Reads

Development and Validation of a Model to Predict Regression of Large Size Hepatocellular Adenoma.

Am J Gastroenterol 2019 Mar 27. Epub 2019 Mar 27.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Introduction: Surgery is advocated in hepatocellular adenomas (HCA) >5 cm that do not regress to <5 cm after 6-12 months. The aim of this study was to develop a model for these patients, estimating the probability of HCA regression to <5 cm at 1 and 2 years follow-up.

Methods: Data were derived from a multicenter retrospective cohort of female patients diagnosed with HCA >5 cm at first follow-up. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000182DOI Listing
March 2019
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Retrieval Practice or Overall Donor and Recipient Risk: What Impacts on Outcomes After Donation After Circulatory Death Liver Transplantation in the United Kingdom?

Liver Transpl 2019 Apr;25(4):545-558

The Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Parameters of retrieval surgery are meticulously documented in the United Kingdom, where up to 40% of livers are donation after circulatory death (DCD) donations. This retrospective analysis focuses on outcomes after transplantation of DCD livers, retrieved by different UK centers between 2011 and 2016. Donor and recipient risk factors and the donor retrieval technique were assessed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25410
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http://dx.doi.org/10.1002/lt.25410DOI Listing
April 2019
3 Reads

Noninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice.

World J Gastroenterol 2019 Mar;25(11):1307-1326

Department of Cardiology, Renmin Hospital of Wuhan University, Institute of Model Animal of Wuhan University, Wuhan 430071, Hubei Province, China.

With the increasing number of individuals with diabetes and obesity, nonalcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent, affecting one-quarter of adults worldwide. The spectrum of NAFLD ranges from simple steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). NAFLD, especially NASH, may progress to fibrosis, leading to cirrhosis and hepatocellular carcinoma. Read More

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http://dx.doi.org/10.3748/wjg.v25.i11.1307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429343PMC