33,337 results match your criteria Liver Transplantation Complications


Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension.

J Pediatr 2020 Jul 11. Epub 2020 Jul 11.

Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO, United States.

Objectives: To identify predictors of portal hypertension, liver transplantation, and death in North American youth with alpha-1-antitrypsin (AAT) deficiency, and compare with AAT deficiency patients elsewhere.

Study Design: The Childhood Liver Disease Research Network (ChiLDReN) Longitudinal Observational Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) is a prospective, cohort study of pediatric cholestatic liver diseases, including AAT deficiency, enrolling PIZZ and PISZ subjects 0-25 years of age seen since November 2007 at 17 tertiary care centers in the US and Canada. Data from standard-of-care baseline and annual follow-up visits were recorded from medical records, history, physical examination, and laboratory studies. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.031DOI Listing

Laparoscopic Liver Resection for Hepatocellular Carcinoma in Child-Pugh A Patients With and Without Portal Hypertension: A Multicentre Study.

World J Surg 2020 Jul 13. Epub 2020 Jul 13.

Department of Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP Paul Brousse Hospital, Villejuif, France.

Background: Laparoscopic liver resection (LLR) may improve outcomes for cirrhotic patients with hepatocellular carcinoma (HCC) and portal hypertension (PHT). The aim of this study was to compare the short-term outcomes after LLR for HCC in cirrhotic patients with and without PHT.

Methods: This multicentric study included 96 HCC patients who underwent LLR. Read More

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http://dx.doi.org/10.1007/s00268-020-05687-9DOI Listing

Novel therapeutics for portal hypertension and fibrosis in chronic liver disease.

Pharmacol Ther 2020 Jul 10:107626. Epub 2020 Jul 10.

Hepatology, Department of Biomedical Research, Inselspital & University of Bern, Switzerland.; Liver Vascular Biology Research Group, Barcelona Hepatic Hemodynamic Unit, IDIBAPS, CIBEREHD, Barcelona, Spain. Electronic address:

Portal hypertension (PH) is the most common non-neoplastic complication of chronic liver disease, determining clinical complications that lead to death or liver transplantation. PH results from increased resistance to portal blood flow through the cirrhotic liver, which is due to hepatic fibrosis and microcirculatory dysfunction. The present review focuses on the pathophysiology of fibrosis and PH, describes currently used treatments, and critically discusses potential therapeutic options. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107626DOI Listing

Transferability of Liver Transplantation Experience to Complex Liver Resection for Locally Advanced Hepatobiliary Malignancy - Lessons Learnt From 3 Decades of Single Center Experience.

Ann Surg 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.

Objective: To study the impact of LT experience on the outcome of CLR for locally advanced hepatobiliary malignancy SUMMARY OF BACKGROUND DATA:: Despite evolution in LT knowledge and surgical techniques in the past decades, there is yet data to evaluate the significance of LT experience in performing CLR.

Methods: Postoperative outcome after CLR between 1995 and 2019 were reviewed and correlated with LT experience in a single center with both LT and CLR service. CLR was defined as hepatectomy with vasculobiliary reconstruction, or multivisceral resection, central bisectionectomy (S4/5/8), or associating liver partition and portal vein ligation for staged hepatectomy. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004227DOI Listing

Aortic valve-sparing procedure-a durable choice in liver transplantation recipient.

Gen Thorac Cardiovasc Surg 2020 Jul 12. Epub 2020 Jul 12.

Sezione Autonoma Di Cardiochirurgia Universitaria, Section of Cardiac Surgery, Pisa University Hospital, Via Paradisa, 2, 56124, Pisa, Italy.

A 44-year old man with aortic regurgitation and aneurysm of the ascending aorta underwent an aortic valve-sparing procedure as a durable treatment before liver transplantation. Since patients with chronic liver failure are at high risk of hemorrhagic complications at time of major surgery, while management of warfarin administration may still represent a concern, the choice of a cardiac procedure which avoids any anticoagulant treatment appeared justified. Read More

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http://dx.doi.org/10.1007/s11748-020-01434-yDOI Listing

The polyphenol-rich extract from chokeberry ( L) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats.

Nutr Metab (Lond) 2020 7;17:54. Epub 2020 Jul 7.

College of Biological Sciences and Technology, Beijing Forestry University, Beijing, 100083 China.

The gut microbiota plays a critical role in obesity and lipid metabolism disorder. Chokeberry ( L) are rich in polyphenols with various physiological and pharmacological activities. We determined serum physiological parameters and fecal microbial components by using related kits, liquid chromatography-mass spectrometry (LC-MS) and 16S rRNA gene sequencing every 10 days. Read More

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http://dx.doi.org/10.1186/s12986-020-00473-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339576PMC

Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):339-376. Epub 2020 Apr 28.

Institute of Liver & Digestive Diseases and Head of Hepatology & Liver Transplant (Medicine), BLK Super Speciality Hospital, Delhi, India.

Acute liver failure (ALF) is an infrequent, unpredictable, potentially fatal complication of acute liver injury (ALI) consequent to varied etiologies. Etiologies of ALF as reported in the literature have regional differences, which affects the clinical presentation and natural course. In this part of the consensus article designed to reflect the clinical practices in India, disease burden, epidemiology, clinical presentation, monitoring, and prognostication have been discussed. Read More

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http://dx.doi.org/10.1016/j.jceh.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335721PMC

[Early efficacy of islet transplantation in the treatment of adult advanced diabetes].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(26):2040-2043

Organ Transplantation Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

To evaluate the safety and efficacy of islet transplantation for patients with advanced diabetes. Five cases of islet allotransplantation were performed on 4 adult recipients. The same blood type adult brain-dead pancreas donors were selected and the islets were prepared in GMP laboratory. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191012-02204DOI Listing

Simultaneous Liver-Kidney Transplantation from Donation after Cardiac Death Donors: An Updated Perspective.

Am J Transplant 2020 Jul 12. Epub 2020 Jul 12.

Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Phoenix, AZ, USA.

Outcomes of both donation after cardiac death (DCD) liver and kidney transplants are improving. Experience in simultaneous simultaneous liver-kidney (SLK) transplantation using DCD donors however remains limited. In an updated cohort (2010-2018), outcomes of 30 DCD SLK and 131 donation after brain death (DBD) SLK from Mayo Clinic Arizona and Minnesota were reviewed. Read More

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http://dx.doi.org/10.1111/ajt.16191DOI Listing

Usefulness of echocardiography to detect cardiac involvement in COVID-19 patients.

Echocardiography 2020 Jul 12. Epub 2020 Jul 12.

Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.

Coronavirus disease 2019 (COVID-19) outbreak is a current global healthcare burden, leading to the life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, evidence showed that, even if the prevalence of COVID-19 damage consists in pulmonary lesions and symptoms, it could also affect other organs, such as heart, liver, and spleen. Particularly, some infected patients refer to the emergency department for cardiovascular symptoms, and around 10% of COVID-19 victims had finally developed heart injury. Read More

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http://dx.doi.org/10.1111/echo.14779DOI Listing

Bilioenteric Reconstruction Techniques in Pediatric Live Donor Liver Transplantation.

Liver Transpl 2020 Jul 11. Epub 2020 Jul 11.

Ege University, Faculty of Medicine, Department of Pediatric Gastroenterology, Izmir, Turkey.

Background: Biliary complications are still a major cause of morbidity following liver transplantation despite the advancements in the surgical technique. While Roux-en-Y hepaticojejunostomy has been the standard technique for years in pediatric cases, there are limited number of reports on the feasibility of duct-to-duct anastomosis with controversial outcomes. With the largest number of patients ever reported on the topic, this study aims to discuss the feasibility of duct-to-duct biliary reconstruction technique in pediatric live donor liver transplantation. Read More

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http://dx.doi.org/10.1002/lt.25845DOI Listing

Trends in liver transplantation for chronic hepatitis B in the era of highly potent antiviral therapies over the past two decades.

Liver Transpl 2020 Jul 11. Epub 2020 Jul 11.

The Liver Transplant Center, Queen Mary Hospital, Hong Kong SAR, Hong Kong.

Despite universal neonatal vaccination being implemented in 1988, the prevalence of chronic hepatitis B (CHB) infection remains high in Hong Kong. With antiviral therapy being available for over two decades now, there should be a significant decline in liver-related complications of CHB patients, especially with regards to cirrhosis and decompensated cirrhosis (1). Read More

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http://dx.doi.org/10.1002/lt.25846DOI Listing

Steroid-sparing maintenance immunosuppression is safe and effective after simultaneous liver kidney transplantation.

Clin Transplant 2020 Jul 11:e14036. Epub 2020 Jul 11.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Optimization of maintenance immunosuppression (mIS) regimens in the transplant recipient requires a balance between sufficient potency to prevent rejection and avoidance of excessive immunosuppression to prevent toxicities and complications. The optimal regimen after simultaneous liver-kidney (SLK) transplantation remains unclear, but small single-center reports have shown success with steroid-sparing regimens. We studied 4184 adult SLK recipients using the Scientific Registry of Transplant Recipients, from 3/1/2002-2/28/2017, on tacrolimus-based regimens at one year post-transplant. Read More

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http://dx.doi.org/10.1111/ctr.14036DOI Listing

Liver resection in Cirrhotic liver: Are there any limits?

Int J Surg 2020 Jul 9. Epub 2020 Jul 9.

Chairman of HPB Surgical Division. Miguel Servet University Hospital. Zaragoza, Spain.

Liver resection remains one of the most technically challenging surgical procedure in abdominal surgery due to the complex anatomical arrangement in the liver and its rich blood supply that constitutes about 20% of the cardiac output per cycle. The challenge for resection in cirrhotic livers is even higher because of the impact of surgical stress and trauma imposed on borderline liver function and the impaired ability for liver regeneration in cirrhotic livers. Nonetheless, evolution and advancement in surgical techniques as well as knowledge in perioperative management of liver resection has led to a substantial improvement in surgical outcome in recent decade. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.050DOI Listing

Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure for Cholangiocarcinoma.

Int J Surg 2020 Jul 6. Epub 2020 Jul 6.

Swiss HPB and Transplantation Center, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland. Electronic address:

Perihilar cholangiocarcinoma (PHCC) has been a great challenge for surgeons, requiring advanced skills and expertise and was often associated with high morbidity and mortality. Resectability rates are up to 75% even in experienced centers. In patients with PHCC, radical liver and bile duct resection aiming R0 surgical margins offers the best long-term survival. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.045DOI Listing

Liver Transplant Complications Radiologist Can't Miss.

Cureus 2020 Jun 5;12(6):e8465. Epub 2020 Jun 5.

Radiology, Instituto Nacional De Ciencias Medicas Y Nutricion Salvador Zubiran, Mexico City, MEX.

Liver transplantation is considered the ideal and definitive therapy for patients with end-stage liver disease. Since 1963 advances in liver transplant surgical techniques and immunosuppressive therapies have improved outcomes and patients' survival. However, early diagnosis of graft dysfunction, through different imaging modalities, is crucial for graft survival. Read More

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http://dx.doi.org/10.7759/cureus.8465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336585PMC

Enteric Dysbiosis in Liver and Kidney Transplant Recipients: A Systematic Review.

Transpl Int 2020 Jul 8. Epub 2020 Jul 8.

Division of Gastroenterology and Hepatology, University Health Network and University of Toronto, Canada, Toronto.

Several factors mediate intestinal microbiome (IM) alterations in transplant recipients, including immunosuppressive (IS) and antimicrobial drugs. Studies on the structure and function of the IM in the post-transplant scenario and its role in the development of metabolic abnormalities, infection, and cancer is limited. We conducted a systematic review to study the taxonomic changes in kidney (KT) and liver transplantation (LT), and their potential contribution to post-transplant complications. Read More

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http://dx.doi.org/10.1111/tri.13696DOI Listing

Favorable outcomes of liver transplantation from controlled circulatory death donors using normothermic regional perfusion compared to brain death donors.

Transplantation 2020 Jun 29. Epub 2020 Jun 29.

Background: Liver transplantation (LT) from controlled donation after circulatory death (cDCD) was initiated in France in 2015 under a protocol based on the use of normothermic regional perfusion (NRP) before organ procurement. The aim was to compare outcomes following cDCD LT with NRP and donation after brain death (DBD) LT.

Methods: This is a multicenter retrospective study comparing cDCD LT with NRP and DBD LT. Read More

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http://dx.doi.org/10.1097/TP.0000000000003372DOI Listing

Big Data in Transplantation Practice - the Devil Is in the Detail - Fontan-associated Liver Disease.

Transplantation 2020 Jul 2. Epub 2020 Jul 2.

Liver Transplant Center, Children's Hospital-Los Angeles, Los Angeles, CA.

Background: As a result of the Fontan procedure, the prognosis of congenital single-ventricle heart disease has improved, with many affected children surviving into adulthood. However, the unanticipated consequences of chronic exposure to Fontan hemodynamics has revealed a new set of secondary noncardiac complications. Fontan-associated liver disease (FALD) is characterized by progressive hepatic fibrosis in nearly all patients post-Fontan, with the potential to develop cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. Read More

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http://dx.doi.org/10.1097/TP.0000000000003308DOI Listing

Consensus recommendations of three-dimensional visualization for diagnosis and management of liver diseases.

Hepatol Int 2020 Jul 7. Epub 2020 Jul 7.

CHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.

Three-dimensional (3D) visualization involves feature extraction and 3D reconstruction of CT images using a computer processing technology. It is a tool for displaying, describing, and interpreting 3D anatomy and morphological features of organs, thus providing intuitive, stereoscopic, and accurate methods for clinical decision-making. It has played an increasingly significant role in the diagnosis and management of liver diseases. Read More

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http://dx.doi.org/10.1007/s12072-020-10052-yDOI Listing

First Case of Full Robotic ALPPS for Intrahepatic Cholangiocarcinoma.

Ann Surg Oncol 2020 Jul 7. Epub 2020 Jul 7.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, MO, Italy.

Background: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for intrahepatic cholangiocarcinoma (ICC) demonstrated good long-term outcomes1 and can increase the rate of resectability in locally advanced ICC;2 however, the rates of postoperative complications (Clavien-Dindo grade III) and mortality range between 13.6 and 44% and 0 and 29%, respectively.3 Minimally invasive strategies may reduce the risk of postoperative morbidity, with the same oncologic outcomes. Read More

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http://dx.doi.org/10.1245/s10434-020-08794-yDOI Listing

Mesenchymal Stromal Cells, a New Player in Reducing Complications From Liver Transplantation?

Front Immunol 2020 19;11:1306. Epub 2020 Jun 19.

National Institute for Health Research Birmingham, Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, University of Birmingham, Birmingham, United Kingdom.

In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clinical outcomes. Mesenchymal stromal cells (MSC) are a multi-potent progenitor cell population that have been utilized to modulate aberrant immune responses in acute and chronic inflammatory conditions. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318292PMC

Pregnancy outcomes in women with liver transplants: systematic review and meta-analysis.

HPB (Oxford) 2020 Jul 4. Epub 2020 Jul 4.

Department of Hepatobiliary, Pancreatic and Transplant Surgery, Freeman Hospital, Newcastle University NHS Foundation Trust Hospitals, Newcastle Upon Tyne, UK; Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

Background: Despite increasing reports of pregnancy in liver transplant recipients, questions remain about the impact of transplantation in pregnancy.

Methods: This systematic review was performed according to PRISMA guidelines and eligible studies were identified through a search of PubMed, Scopus and Cochrane CENTRAL databases up to 26th December 2019 for studies reporting pregnancy with liver transplant. A meta-analysis was conducted with the use of random-effects modelling and prospectively registered with the PROSPERO database. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.05.001DOI Listing

Donor-derived human herpesvirus 8 and development of Kaposi sarcoma among six recipients of organs from donors with high risk sexual and substance use behavior.

Am J Transplant 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Kaposi sarcoma (KS) can develop following organ transplantation through reactivation of recipient human herpesvirus 8 (HHV-8) infection or through donor-derived HHV-8 transmission. We describe six cases of donor-derived HHV-8 infection and KS investigated July 2018 - January 2020. Organs from six donors, retrospectively identified as HHV-8-positive, with a history of drug use disorder, were transplanted into 22 recipients. Read More

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http://dx.doi.org/10.1111/ajt.16181DOI Listing

Acute-on-chronic liver failure in liver transplant candidates with non-alcoholic steatohepatitis.

Transl Gastroenterol Hepatol 2020 5;5:38. Epub 2020 Jul 5.

Institute for Digestive Heath and Liver Disease, Mercy Medical Center, Baltimore, MD, USA.

Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. It is expected that non-alcoholic steatohepatitis (NASH), NASH-related cirrhosis and its decompensated forms will increase further in the next two decades. Acute-on-chronic liver failure (ACLF) is a distinct syndrome characterized by rapid deterioration of liver function in patients with chronic liver disease that is associated with development of one or more organ failures, and carries a very high short-term mortality. Read More

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http://dx.doi.org/10.21037/tgh.2019.10.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063516PMC

Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation.

Transl Gastroenterol Hepatol 2020 5;5:36. Epub 2020 Jul 5.

University of Tennessee Health Science Center, Memphis, TN, USA.

Along with the obesity epidemic there has been a major increase in non-alcoholic fatty liver disease (NAFLD) prevalence, paralleling a steady increase in cirrhosis of the liver and hepatocellular cancer (HCC) related to NAFLD. Currently, NAFLD (related HCC and cirrhosis) is the second most common cause for liver transplantation (LT) and it is projected to take the top spot in the next 3-5 years. Patients with NAFLD cirrhosis and HCC have a unique set of comorbidities which potentially increases their risk for cardiovascular disease (CVD) and mortality. Read More

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http://dx.doi.org/10.21037/tgh.2019.12.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063524PMC

Optimizing biliary outcomes in living donor liver transplantation: Evolution towards standardization in a high-volume center.

Hepatobiliary Pancreat Dis Int 2020 Jun 21. Epub 2020 Jun 21.

Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta-Pei Road, Niao Sung, Kaohsiung 833, Taiwan, China.

Biliary complications have always been a dreaded cause of morbidity after living donor liver transplantation. While intrinsic variations in both graft and recipient biliary anatomy remain a significant factor to the difficulty of biliary reconstruction, our institution has taken advantage of its high volume of cases to critically review and evaluate modifiable operative risk factors, in particular, our surgical protocols. We present herein, the evolution of our reconstructive biliary technique from conventional methods to our current standard of microsurgical biliary reconstruction for both graft and recipient ducts. Read More

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http://dx.doi.org/10.1016/j.hbpd.2020.06.012DOI Listing

In Vitro Evaluation of Pro- and Anticoagulant Drugs in Children with End-Stage Liver Disease Undergoing Liver Transplantation.

Thromb Haemost 2020 Jul 6. Epub 2020 Jul 6.

Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background:  Pro- and anticoagulant drugs are commonly used in pediatric liver transplantation to prevent and treat thrombotic and bleeding complications. However, the combination of baseline hemostatic changes in children with liver disease and additional changes induced by transplantation makes this very challenging. This study aimed to analyze the efficacy of clinically available pro- and anticoagulant drugs in plasma from children undergoing liver transplantation. Read More

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http://dx.doi.org/10.1055/s-0040-1713752DOI Listing

Management of Biliary Stricture in Pediatric Living Donor Liver Transplantation Recipients.

Transplant Proc 2020 Jul 2. Epub 2020 Jul 2.

Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niao-Sung, Kaohsiung, Taiwan. Electronic address:

Objective: Evaluation of the efficiency of percutaneous transhepatic cholangial drainage (PTCD) for biliary stricture after living donor liver transplantation (LDLT) in pediatric patients.

Materials And Methods: We retrospectively analyzed biliary stricture observed in pediatric biliary atresia. LDLT patients were studied between June 1994 and November 2017. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.132DOI Listing

Immune function and infectious complications in children with jejunoileal atresia.

J Pediatr Surg 2020 Jun 5. Epub 2020 Jun 5.

Pediatric Gastroenterology, Hepatology and Nutrition, University of Nebraska Medical Center and Children's Hospital & Medical Center, Omaha, NE, United States. Electronic address:

Objective: Little is known about differences in immune function among children with multiple intestinal atresia (MIA) and those with isolated intestinal atresia (IA), and how such differences may manifest as infectious complications and patient outcomes. This study aimed to investigate the immune function and its impact on patient outcomes in IA and MIA children.

Methods: A single-center retrospective cohort study included children aged 0-19 years with intestinal atresia who were referred to a multidisciplinary intestinal rehabilitation program from 1/2000 to 12/2016. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.036DOI Listing

Self-Management Behavior, Symptom Occurrence, and Psychological Distress in Liver Transplant Recipients in China: A Descriptive Correlational Study.

Transplant Proc 2020 Jul 1. Epub 2020 Jul 1.

School of Nursing, Fudan University, Shanghai, People's Republic of China.

Purpose: Little is known about the status of self-management behaviors, symptoms, and psychological distress in liver transplant recipients. This study aimed to assess these variables and explore their relationships in a sample of liver transplant recipients in Shanghai, China.

Basic Procedures: A descriptive correlational design was used in this study. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.02.036DOI Listing

Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver disease.

Clin Gastroenterol Hepatol 2020 Jul 1. Epub 2020 Jul 1.

Centre d'Investigation de la Fibrose Hépatique, INSERM U1053, Hôpital Haut-Lévêque, Bordeaux University Hospital, Pessac, France.

Background & Aims: Patients with advanced fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at risk of developing hepatic and extrahepatic complications. We investigated whether, in a large cohort of patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements (LSMs) and their changes can be used to identify patients at risk for liver-related and extrahepatic events.

Methods: We performed a retrospective analysis of consecutive patients with NAFLD (n=1039) with a histologic diagnosis of F3-F4 fibrosis and/or LSMs>10 KPa, followed for at least 6 months, from medical centers in 6 countries. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.045DOI Listing

Portal vein stent placement after hepatobiliary and pancreatic surgery.

Langenbecks Arch Surg 2020 Jul 3. Epub 2020 Jul 3.

Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.

Purpose: To evaluate the long-term outcomes of percutaneous transhepatic stent placement for portal vein (PV) stenosis after liver transplantation (LT) and hepato-pancreato-biliary (HPB) surgery.

Methods: Retrospective study of 455 patients who underwent LT and 522 patients who underwent resection of the pancreatic head between June 2011 and February 2016. Technical success, clinical success, patency, and complications were evaluated for both groups. Read More

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http://dx.doi.org/10.1007/s00423-020-01917-9DOI Listing

Budd-Chiari Syndrome: An Uncommon Cause of Chronic Liver Disease that Cannot Be Missed.

Clin Liver Dis 2020 Aug 2;24(3):453-481. Epub 2020 Jun 2.

Section of Digestive Diseases, Yale Liver Center, Yale University School of Medicine, 333 Cedar Street, LMP 1080, New Haven, CT 06520, USA. Electronic address:

Budd-Chiari syndrome (BCS), or hepatic venous outflow obstruction, is a rare cause of liver disease that should not be missed. Variable clinical presentation among patients with BCS necessitates a high index of suspicion to avoid missing this life-threatening diagnosis. BCS is characterized as primary or secondary, depending on etiology of venous obstruction. Read More

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http://dx.doi.org/10.1016/j.cld.2020.04.012DOI Listing

Nasal Bridles for Securing Nasoenteric Feeding Tubes: A Review of Clinical Effectiveness and Potential Complications.

Cureus 2020 May 28;12(5):e8325. Epub 2020 May 28.

Transplant Hepatology, Cleveland Clinic Florida, Weston, USA.

Nasal bridle is a feeding tube retaining device that is now increasingly used worldwide. While common complications tend to be minor, it is important to remain vigilant for newer adverse events. We hereby delineate the case of an elderly female who required nasoenteric feeding tube following simultaneous liver-kidney transplantation. Read More

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http://dx.doi.org/10.7759/cureus.8325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325339PMC

Clinical impact of irreversible electroporation ablation for unresectable hilar cholangiocarcinoma.

Sci Rep 2020 Jul 2;10(1):10883. Epub 2020 Jul 2.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei City, 10002, Taiwan.

Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in Asia received IRE treatment between June 2015 and July 2017. Read More

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http://dx.doi.org/10.1038/s41598-020-67772-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331634PMC

Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China.

Infect Dis Poverty 2020 Jul 2;9(1):82. Epub 2020 Jul 2.

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Donghu road 169, Wuhan, 430071, China.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection because of the immunosuppressive state cause by therapies on tumors. Read More

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http://dx.doi.org/10.1186/s40249-020-00707-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330531PMC

Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation.

J Thromb Haemost 2020 Jul 2. Epub 2020 Jul 2.

Department of Surgery, section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined. Read More

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http://dx.doi.org/10.1111/jth.14983DOI Listing

Removal of the Tumor Thrombus from the Right Atrium without Extracorporeal Circulation: Emphasis on the Displacement of the Tumor Apex.

Adv Urol 2020 18;2020:6063018. Epub 2020 Jun 18.

Dniprovsky Regional Clinical Oncology Dispensary, Dnipro 49055, Ukraine.

Objectives: To assess the outcomes of cavoatrial tumor thrombus removal using the liver transplantation technique for thrombectomy, a retrospective study was conducted.

Materials And Methods: Five patients with atrial tumor thrombi who underwent piggy-back mobilization of the liver, surgical access to the right atrium from the abdominal cavity, and external manual repositioning of the thrombus apex below the diaphragm (milking maneuver) were included into the study. Extracorporeal circulation was used in none of the cases. Read More

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http://dx.doi.org/10.1155/2020/6063018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320280PMC

-acetylcysteine as a treatment for amatoxin poisoning: a systematic review.

Clin Toxicol (Phila) 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Emergency Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Amatoxin leads to the majority of deaths by mushroom poisoning around the world. Amatoxin causes gastrointestinal disturbances and multiple organ dysfunction, including liver and renal failure. As a potential treatment for amatoxin poisoning, -acetylcysteine (NAC) has been used for decades but its benefit is still unproven. Read More

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http://dx.doi.org/10.1080/15563650.2020.1784428DOI Listing

Accurate assessment of nonalcoholic fatty liver disease lesions in liver allograft biopsies by a smartphone platform: A proof of concept.

Microsc Res Tech 2020 Jul 1. Epub 2020 Jul 1.

Department of Pathology, CHU de Nice, Nice, France.

Macrovesicular steatosis (MS) is a major risk factor for liver graft failure after transplantation and pathological microscopic examination of a frozen tissue section remains the gold standard for its assessment. However, the latter requires an experienced in-house pathologist for correct and rapid diagnosis as well as specific equipment that is not always available. Smartphones, which are must-have tools for everyone, are very suitable for incorporation into promising technology to generate moveable diagnostic tools as for telepathology. Read More

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http://dx.doi.org/10.1002/jemt.23478DOI Listing

Novel approach for the diagnosis of occult cytomegalovirus cholangitis after pediatric liver transplantation: A case report.

World J Clin Cases 2020 Jun;8(12):2597-2602

Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Cytomegalovirus (CMV) infection is a common infection in liver transplant recipients, which is related to chronic rejection and biliary complications. It is often diagnosed based on serum CMV-DNA or CMV pp65. To our knowledge, this is the first report of the successful treatment of occult CMV cholangitis in a pediatric liver transplantation (LT) recipient. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322438PMC

A Single-Center Experience in Portal Flow Augmentation in Liver Transplantation With Prior Large Spontaneous Splenorenal Shunt.

Transplant Proc 2020 Jun 27. Epub 2020 Jun 27.

Akdeniz University, Faculty of Medicine, Department of General Surgery, Tuncer Karpuzoglu Organ Transplantation Center, Antalya, Turkey.

Large portosystemic shunts may cause portal steal syndrome in liver transplantation (LT). Because of the possible devastating consequences of the syndrome, the authors recommend perioperative management of these large shunts. Fourteen adult recipients who underwent portal flow augmentation, including left renal vein ligation (LRVL), renoportal anastomosis (RPA), shunt ligation (SL), and splenic vein ligation (SVL) for large spontaneous splenorenal shunt (SSRS), are included in this study, and the results were analyzed. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.015DOI Listing

A novel complete autosomal recessive STAT1 LOF variant causes immunodeficiency with hemophagocytic lymphohistiocytosis-like hyperinflammation.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany; German Centre for Infection Research (DZIF), Munich, Germany. Electronic address:

Background: Complete STAT1 deficiency causes a rare primary immunodeficiency that is characterized by defective IFN-dependent gene expression leading to life-threatening viral and mycobacterial infections early in life.

Objective: Characterization of a novel STAT1 loss-of-function (LOF) variant leading to pathological infection susceptibility and hyperinflammation.

Methods: Clinical, immunological and genetic characterization of a patient with severe infections and hemophagocytic lymphohistiocytosis (HLH)-like hyperinflammation. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.06.034DOI Listing

Impact of Pre-existing Inflammatory Bowel Disease on the Outcome of Liver Transplantation for Primary Sclerosing Cholangitis.

Liver Transpl 2020 Jun 30. Epub 2020 Jun 30.

Service d'hépatologie, Hôpital Haut Lévêque, CHU de Bordeaux, France.

Approximately 80% of patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD). The effect of IBD on the outcomes of liver transplantation (LT) for PSC is unclear. We retrospectively collected data from adults who underwent LT for PSC from 1989 to 2017 in four French LT centers. Read More

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http://dx.doi.org/10.1002/lt.25838DOI Listing

Left-sided portal hypertension after pancreatoduodenectomy with resection of the portal/superior mesenteric vein confluence. Results of a systematic review.

Surgery 2020 Jun 26. Epub 2020 Jun 26.

Department of Medical and Surgical Sciences and Translational Medicine, St Andrea University Hospital, Sapienza University, Rome, Italy.

Background: Pancreatoduodenectomy with synchronous resection of the portal vein/superior mesenteric vein confluence may result in the development of left-sided portal hypertension. Left-sided portal hypertension presents with splenomegaly and varices and may cause severe gastrointestinal bleeding. The aim of the study is to review the incidence, treatment, and preventive strategies of left-sided portal hypertension. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.030DOI Listing

Safety of endoscopic retrograde cholangiopancreatography in the pediatric population: a multicentre study.

Endoscopy 2020 Jun 29. Epub 2020 Jun 29.

Regional University Hospital of Nancy, Hepato-Gastroenterology Department, Vandoeuvre-les-Nancy, France.

Introduction: The aims of this retrospective multicentre study were to assess the technical success and adverse events of ERCP procedures in children in French and Belgian centres.

Methods: All children aged one day to seventeen years who underwent ERCP between January 2008 and March 2019 in 15 tertiary care hospitals were retrospectively included.

Results: 271 children underwent 470 ERCP procedures. Read More

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http://dx.doi.org/10.1055/a-1209-0155DOI Listing

[Some practical issues in the management of patients with decompensated liver cirrhosis].

Ter Arkh 2019 Aug 15;91(8):148-154. Epub 2019 Aug 15.

Sechenov First Moscow State Medical University (Sechenov University).

The natural course of cirrhosis is characterized by a shift from a compensated stage without clinical manifestations to a subsequent decompensated stage, which is characterized by the development of obvious clinical symptoms, the most frequent of which are ascites, bleeding from varicose veins, bacterial infections, encephalopathy. The articles and reviews of recent years emphasize the importance of etiotropic treatment of liver cirrhosis at any stage, including the final one. In addition, pathogenetic and symptomatic therapy aimed at treating complications of cirrhosis of the liver: ascites, dilution hyponatremia, gastrointestinal bleeding, bacterial infections, and kidney damage comes to the forefront at the stage of decompensation, which allows the patient to be on the waiting list for liver transplantation. Read More

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http://dx.doi.org/10.26442/00403660.2019.08.000391DOI Listing

Intraoperative renal replacement therapy for liver transplantation: Is there really a benefit?

Liver Transpl 2020 Jun 27. Epub 2020 Jun 27.

Seattle, Washington, United States.

Acute kidney injury at the time of liver transplantation( LT) is associated with increased mortality, particularly for those patients who require hemodialysis (Zand). There are several theoretical benefits of intraoperative RRT (IORRT). Dialysis can correct metabolic acidosis and electrolyte abnormalities including hyperkalemia common during liver transplantation, particularly during the anhepatic phase can reduce fluid overload, especially when large amounts of blood product transfusions are administered. Read More

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http://dx.doi.org/10.1002/lt.25836DOI Listing

Bariatric Surgery Patients Are at Risk for Alcoholic Liver Disease with Need for Liver Transplantation.

Obes Surg 2020 Jun 27. Epub 2020 Jun 27.

Department of Gastroenterology and Hepatology, Hepatology Research Unit, Ghent University, 1K12IE, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.

Recent studies have indicated that patients with prior bariatric surgery (BS) are at risk for developing alcohol use disorder. We explored patient demographics and impact on liver disease severity in 11 patients with prior BS listed for transplantation due to alcoholic liver disease, and compared these with 177 patients without BS. BS patients were younger with a female predominance and presented with more severe decompensation. Read More

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http://dx.doi.org/10.1007/s11695-020-04806-8DOI Listing