4,984 results match your criteria Liver Transplantation[Journal]


Predictive value of hepatic venous pressure gradient for graft hemodynamics in living donor liver transplantation.

Liver Transpl 2019 Apr 13. Epub 2019 Apr 13.

Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.

Hepatic venous pressure gradient (HVPG) is known to correlate with severity of portal hypertension in patients with liver cirrhosis. This retrospective study investigated the clinical value of preoperative measurement of HVPG in patients who underwent adult-to-adult LDLT and its predictive value for hepatic hemodynamics after graft reperfusion. For this study, seventy-five patients who underwent adult-to-adult LDLT were divided into two groups (HVPG < 16 mmHg or HVPG > 16 mmHg) to investigate the correlation between preoperative HVPG and characteristics and surgical outcomes of the patients, including portal vein flow (PVF) and hepatic artery flow (HAF) after graft reperfusion. Read More

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http://dx.doi.org/10.1002/lt.25471DOI Listing

Optimal Biliary Drainage for Patients with Biliary Anastomotic Strictures After Right-Lobe Living Donor Liver Transplantation.

Liver Transpl 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

Background/aims: There are usually two bile duct anastomosis sites, namely, the right anterior segmental duct (RASD) and the right posterior segmental duct (RPSD), in right lobe (RL) living donor liver transplantation (LDLT). This study aimed to evaluate the optimal treatment for biliary strictures following RL-LDLT with respect to unilateral or bilateral drainage technique.

Methods: From January 2005 to December 2017, 883 patients at Seoul National University Hospital underwent RL-LDLT. Read More

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http://dx.doi.org/10.1002/lt.25472DOI Listing

Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization.

Liver Transpl 2019 Apr 10. Epub 2019 Apr 10.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, 210029, China.

Background: Hyperglycemia aggravates hepatic ischemia/reperfusion injury (IRI) but the underlying mechanism remains elusive. Sphingosine 1-phosphate (S1P)/S1P receptors (S1PRs) have been implicated in metabolic and inflammatory diseases. Here, we clarify whether and how S1P/S1PRs are involved in hyperglycemia-related liver IRI. Read More

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http://dx.doi.org/10.1002/lt.25470DOI Listing

Physicians' perspectives on palliative care for patients with end-stage liver disease: a national survey study.

Liver Transpl 2019 Apr 9. Epub 2019 Apr 9.

Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Specialty palliative care (PC) is underutilized for patients with end-stage liver disease (ESLD). We sought to examine hepatologists' and gastroenterologists' attitudes about PC for patients with ESLD.

Methods: We conducted a cross-sectional survey of hepatologists' and gastroenterologists' who provide care to patients with ESLD recruited from the American Association for the Study of Liver Diseases membership directory. Read More

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http://dx.doi.org/10.1002/lt.25469DOI Listing

REPLY: Predictors of de novo Non-alcoholic Fatty Liver Disease (NAFLD) post-Liver Transplantation and Associated Fibrosis.

Liver Transpl 2019 Apr 4. Epub 2019 Apr 4.

Multi-Organ Transplant Program.

We thank Dr. Saigal and colleagues for their interest in our article entitled "Predictors of De Novo Nonalcoholic Fatty Liver Disease after Liver Transplantation and Associated Fibrosis". We agree that the bias towards the limited clinical significance of de novo NAFLD in prior studies is likely related to small cohorts and relatively short duration follow up. Read More

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http://dx.doi.org/10.1002/lt.25465DOI Listing
April 2019
2 Reads

An Advanced Practice Practitioner-Based Program to Reduce 30- and 90-day Readmissions After Liver Transplantation.

Liver Transpl 2019 Apr 4. Epub 2019 Apr 4.

Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, United States.

Background: Hospital readmissions after liver transplantation (LT) are common and associated with increased morbidity and cost. High readmission rates at our center motivated a change in practice with adoption of a nurse practitioner (NP)-based post-transplant care program. We sought to determine if this program was effective in reducing 30- and 90-day readmissions after LT, and to identify variables associated with readmission. Read More

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http://dx.doi.org/10.1002/lt.25466DOI Listing
April 2019
1 Read

Liver transplant candidate attitudes towards organs from increased risk donors.

Liver Transpl 2019 Apr 4. Epub 2019 Apr 4.

Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada.

Background: Increased Risk Donors (IRDs) are a significant proportion of the deceased organ donor pool but may be declined by patients on the liver transplant waiting list due to various factors. We conducted a survey of patients with end-stage liver disease awaiting a liver transplant in order to determine the factors leading to the acceptance of an IRD organ, and what strategies we could use to better inform and increase this rate of acceptance.

Methods: Adult liver transplant candidates who were outpatients completed a survey consisting of 51 questions on a 5-point Likert scale, with categories related to demographics, knowledge of IRDs, and likelihood of acceptance. Read More

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http://dx.doi.org/10.1002/lt.25467DOI Listing

Chronic kidney disease after liver transplantation: can we safely use extended criteria grafts?

Liver Transpl 2019 Apr 4. Epub 2019 Apr 4.

The Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom.

Background And Aim: The use of ECD grafts has been associated with acute kidney injury (AKI) after liver transplantation. However, the relation between graft quality and development of CKD remains unknown. The aim of this study was therefore to analyse the impact of extended criteria (ECD) grafts for chronic kidney disease (CKD) after liver transplantation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25468
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http://dx.doi.org/10.1002/lt.25468DOI Listing
April 2019
3 Reads

Minimally Invasive Treatment of Metabolic Decompensation Due to Portal Steal In Auxiliary Liver Transplantation.

Liver Transpl 2019 Apr 2. Epub 2019 Apr 2.

The Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharat Institute of Higher Education & Research, Chennai, India.

Liver transplantation (LT), especially auxiliary partial LT (APOLT) is an excellent treatment option for patients with propionic academia (PA). It avoids the demerits and morbidity associated with long-term dietary modifications. Portal steal however, remains a major issue with APOLT, and is one of the reasons for it not being more widely accepted. Read More

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http://dx.doi.org/10.1002/lt.25463DOI Listing

A 'Back-to-base' Experience of Human Normothermic Ex Situ Liver Perfusion: Does the chill kill?

Liver Transpl 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgery, University of Alberta, Edmonton, Canada.

Rationale: Normothermic machine perfusion (NMP) has been shown to protect livers from injury between procurement and transplantation in a randomized controlled trial, where the machine was transported to and from the donor center. The aim of this study was to determine whether an alternative, more practical 'Back-to-base' approach after initial static cold storage (SCS) would compromise beneficial outcomes.

Methods: Between February 2015 and June 2018, a non-randomized pilot study was performed at a single site. Read More

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http://dx.doi.org/10.1002/lt.25464DOI Listing
April 2019
6 Reads

Expanding the Donor Pool with Utilization of Extended Criteria DCD Livers.

Liver Transpl 2019 Mar 31. Epub 2019 Mar 31.

Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

Utilization of donation after circulatory death donor (DCD) livers for transplantation has remained cautious in the U.S. The aim of this study was to demonstrate the expansion of DCD liver transplant (LT) program with the use of extended criteria DCD livers. Read More

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http://dx.doi.org/10.1002/lt.25462DOI Listing

Cardiovascular Morbidity After Pediatric Liver Transplantation: A Matter of Life Expectancy?

Authors:
Valérie A McLin

Liver Transpl 2019 May;25(5):692-694

Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/lt.25461DOI Listing

Split-Liver Allocation: An Underused Opportunity to Expand Access to Liver Transplantation.

Liver Transpl 2019 May;25(5):690-691

Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, San Francisco, CA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25458
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http://dx.doi.org/10.1002/lt.25458DOI Listing
May 2019
3 Reads

Outcomes in Living Liver Donor "Heroes" After the Spotlight Fades.

Liver Transpl 2019 May;25(5):685-687

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.

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http://dx.doi.org/10.1002/lt.25459DOI Listing

The High-Risk Alcoholism Relapse Score Predicts Alcohol Relapse Among Liver Transplant Candidates with Less Than Six Months of Abstinence.

Liver Transpl 2019 Mar 28. Epub 2019 Mar 28.

Liver Transplant Unit, IDIBAPS, CIBERehd, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Background & Aims: The selection of liver transplant (LT) candidates with alcohol use disorder is influenced by the risk of alcohol relapse (AR) after LT. We aimed to investigate the risk factors of AR after LT and its impact on graft and recipient outcomes.

Methods: Retrospective study including all consecutive patients with alcohol use disorder undergoing LT from January 2004 to April 2016 (n=309), excluding alcoholic hepatitis. Read More

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http://dx.doi.org/10.1002/lt.25460DOI Listing
March 2019
1 Read

Retrieval Practice or Overall Donor and Recipient Risk: What Impacts on Outcomes After Donation After Circulatory Death Liver Transplantation in the United Kingdom?

Liver Transpl 2019 Apr;25(4):545-558

The Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Parameters of retrieval surgery are meticulously documented in the United Kingdom, where up to 40% of livers are donation after circulatory death (DCD) donations. This retrospective analysis focuses on outcomes after transplantation of DCD livers, retrieved by different UK centers between 2011 and 2016. Donor and recipient risk factors and the donor retrieval technique were assessed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25410
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http://dx.doi.org/10.1002/lt.25410DOI Listing
April 2019
3 Reads

Liver Transplantation and Marijuana Use: Needing a Joint Approach.

Authors:
James Neuberger

Liver Transpl 2019 May;25(5):688-689

Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/lt.25456DOI Listing

The Effects of Liver Transplantation in Children with Niemann-Pick Disease Type B.

Liver Transpl 2019 Mar 26. Epub 2019 Mar 26.

Department of Liver Surgery, Ren Ji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.

We evaluated the effects of liver transplantation in children with Niemann-Pick disease (NPD) type B. From October 2006 to October 2018, 7 of 1512 children that received liver transplantation at Ren Ji Hospital were diagnosed as NPD type B. The median age at diagnosis is 12-month (6-14 months) with initial presentations of hepatosplenomegaly, growth retardation, repeated pneumonia and diarrhea. Read More

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http://dx.doi.org/10.1002/lt.25457DOI Listing
March 2019
2 Reads

Clinical Implications of Donor Warm and Cold Ischemia Time in Donor after Circulatory Death (DCD) Liver Transplantation.

Liver Transpl 2019 Mar 26. Epub 2019 Mar 26.

Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.

The utilization of donor after circulatory death (DCD) liver allografts has been constrained by limitations in the duration of donor warm ischemia time (DWIT), agonal time (DAT), and cold ischemia time (CIT). The purpose of this study is to assess the impact of longer DWIT, DAT, and CIT on graft survival and other outcomes in DCD liver transplants. The Scientific Registry of Transplant Recipients was queried for adult liver transplants from DCD donors between 2009 and 2015. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25453
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http://dx.doi.org/10.1002/lt.25453DOI Listing
March 2019
11 Reads

Antegrade hepatic artery and portal vein perfusion versus portal vein perfusion alone in live donor liver transplantation: a randomized trial.

Liver Transpl 2019 Mar 25. Epub 2019 Mar 25.

Department of Gastrointestinal Surgery & Solid Organ Transplant, Amrita Institute of Medical Sciences & Research Centre, Amrita University, Kochi, Kerala, India, 682041.

Background: Traditionally, deceased donor liver grafts receive dual perfusion through the portal vein and the hepatic artery(HA) either in-situ or on the back-table. Hepatic artery perfusion is avoided in live donor liver grafts for fear of damage to the intima and consequent risk of hepatic artery thrombosis(HAT). However, biliary vasculature is predominantly derived from the HA. Read More

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http://dx.doi.org/10.1002/lt.25455DOI Listing

Impact of Chronic Kidney Disease on Outcomes in Cirrhosis.

Liver Transpl 2019 Mar 25. Epub 2019 Mar 25.

Commonwealth University of Virginia and McGuire VA Medical Center, Richmond, Virginia, USA.

Background & Aim: We hypothesize that the prevalence of chronic kidney disease (CKD) amongst cirrhotic patients has increased due to increased prevalence of CKD associated co-morbidities such as diabetes. We aimed to assess the characteristics of hospitalized cirrhotic patients with CKD and its impact on renal and patient outcomes.

Methods: The North American Consortium for the Study of End-Stage Liver Disease (NACSELD) prospectively enrolled non-electively admitted cirrhotic patients and collected data on demographics, laboratory results, in-hospital clinical course, and post-discharge 3-month outcomes. Read More

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http://dx.doi.org/10.1002/lt.25454DOI Listing
March 2019
4 Reads

Acute severe autoimmune hepatitis - Corticosteroids or liver transplantation?

Liver Transpl 2019 Mar 22. Epub 2019 Mar 22.

Institute of Liver Studies, King's College Hospital, London, SE5 9RS, United Kingdom.

Acute severe presentations of autoimmune hepatitis (AIH) represent a challenge for the transplant community. As an entity, it is poorly characterized and there is weak evidence base to guide diagnosis and treatment. Early identification of acute severe AIH (AS-AIH) is key, as it determines the initiation of corticosteroids which can be life-saving. Read More

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http://dx.doi.org/10.1002/lt.25451DOI Listing
March 2019
1 Read

Access to the Portal System Via the Mesentery for Establishing Venous Bypass in Liver Transplantation.

Liver Transpl 2019 May 2;25(5):807-810. Epub 2019 Apr 2.

Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, Créteil, France.

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http://dx.doi.org/10.1002/lt.25452DOI Listing

The Range and Reproducibility of the Liver Frailty Index.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, University of California-San Francisco, San Francisco, CA.

The Liver Frailty Index (LFI), composed of three performance-based tests (grip strength, chair stands, balance), is a tool specifically developed in patients with cirrhosis to objectively measure physical function, a critical determinant of health outcomes. We aimed to: 1) determine the range of LFI scores in adults with chronic liver disease but without cirrhosis, 2) determine the range of LFI scores in adults without known liver disease, and 3) evaluate reproducibility of the LFI in adults with cirrhosis listed for liver transplantation. Intraclass correlation coefficient (ICC) assessed inter-rater reliability of the LFI. Read More

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http://dx.doi.org/10.1002/lt.25449DOI Listing

Predictors of De Novo Nonalcoholic Fatty Liver Disease After Liver Transplantation: many unanswered questions.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Medanta Institute of Liver Transplantation and Regenerative medicine, Medanta The Medicity, Gurugram, India.

Post transplant non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) is very common. The progression of fibrosis is accelerated in these patients as compared to NASH in general population. A meta-analysis including 2166 patients showed a 26% pooled prevalence of de novo NAFLD. Read More

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http://dx.doi.org/10.1002/lt.25450DOI Listing
March 2019
1 Read

Underestimation of Liver Transplantation for Alcoholic Hepatitis in the National Transplant Database.

Liver Transpl 2019 May 29;25(5):706-711. Epub 2019 Mar 29.

Department of Gastroenterology, Keck School of Medicine of University of Southern California, Los Angeles, CA.

Alcohol-associated liver disease (ALD) can be coded in United Network for Organ Sharing (UNOS) as either alcoholic cirrhosis or alcoholic hepatitis (AH), without having specific criteria to assign either diagnosis. In this multicenter American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH) study, we sought to assess the concordance of the clinician diagnosis of AH at liver transplantation (LT) listing versus UNOS data entry of AH as listing diagnosis. In a prior study, consecutive early LT recipients transplanted for AH between 2012 and 2017 were identified by chart review at 10 ACCELERATE-AH sites. Read More

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http://dx.doi.org/10.1002/lt.25448DOI Listing
May 2019
2 Reads

Vascular Remodeling of Visceral Arteries Following Interruption of the Splenic Artery During Liver Transplantation.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Liver Transplant Center, General Surgery 2U, University of Torino, A.O.U. Città Della Salute e Della Scienza, Torino, Italy.

Splenic artery (SA) ligation can be performed during liver transplantation (LT) to avoid portal hyperperfusion, which is involved in the pathogenesis of both small-for-size and SA syndrome. The SA can also be used as an inflow for arterial reconstruction. Exceptionally, SA interruption or agenesis has been associated with positive remodeling of collateral arteries supplying the spleen via the left gastric artery (LGA), short gastric vessels, and the gastroepiploic arcade (GEA), with subsequent severe upper gastrointestinal (GI) bleeding. Read More

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http://dx.doi.org/10.1002/lt.25447DOI Listing
March 2019
1 Read

State-Based Liver Distribution: Broad Sharing With Less Harm to Vulnerable and Underserved Communities Compared With Concentric Circles.

Liver Transpl 2019 Apr 14;25(4):588-597. Epub 2019 Mar 14.

Transplant Center, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN.

Allocation of livers for transplantation faces regulatory pressure to move toward broader sharing. A current proposal supported by the United Network for Organ Sharing Board of Directors relies on concentric circles, but its effect on socioeconomic inequities in access to transplant services is poorly understood. In this article, we offer a proposal that uses the state of donation as a unit of distribution, given that the state is a recognized unit of legal jurisdiction and socioeconomic health in many contexts. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25425
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http://dx.doi.org/10.1002/lt.25425DOI Listing
April 2019
4 Reads

The causes and outcomes of early relaparotomy following pediatric living donor liver transplantation.

Liver Transpl 2019 Mar 13. Epub 2019 Mar 13.

Department of Transplant Surgery, Jichi Medical University.

Introduction: Early relaparotomy of adult recipients after living donor liver transplantation (LDLT) is significantly associated with poor prognosis. However, there are few reports focusing on pediatric recipients after LDLT. The aim of this study is to clarify the causes and outcomes of early relaparotomy after pediatric LDLT. Read More

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http://doi.wiley.com/10.1002/lt.25446
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http://dx.doi.org/10.1002/lt.25446DOI Listing
March 2019
5 Reads

NASH Is the Most Rapidly Growing Etiology for Acute-on-Chronic Liver Failure-Related Hospitalization and Disease Burden in the United States: A Population-Based Study.

Liver Transpl 2019 May;25(5):695-705

University of South Dakota Sanford School of Medicine and Avera Transplant Institute, Sioux Falls, SD.

Acute-on-chronic liver failure (ACLF) is characterized by multiple organ failure (OF) with high short-term mortality. There is lack of population-based data on trends on etiology specific ACLF related burden. National Inpatient Sample (2006-2014) was queried using ICD-09 codes for admissions with cirrhosis and ACLF (≥2 extrahepatic OF). Read More

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http://dx.doi.org/10.1002/lt.25443DOI Listing
May 2019
1 Read

Live donor liver transplantation for acute liver failure - Donor safety and recipient outcome.

Liver Transpl 2019 Mar 12. Epub 2019 Mar 12.

Department of Hepatology, Institute of Liver & Biliary Sciences.

In countries where deceased organ donation is sparse, emergency live donor liver transplantation(LDLT) is the only lifesaving option in selectpatients with acute liver failure(ALF). Aim of the current study is live liver donor safety and recipient outcomes following LDLT for ALF. Analysis of consecutive patients undergoing LDLT for ALF from March 2011 to February 2018was done. Read More

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http://dx.doi.org/10.1002/lt.25445DOI Listing
March 2019
2 Reads

State-Based Liver Allocation: Is It a Viable Alternative?

Authors:
Ryutaro Hirose

Liver Transpl 2019 Apr;25(4):535-537

Department of Surgery, University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1002/lt.25441DOI Listing

Current Status of Simultaneous Liver-Kidney Transplantation in the United States.

Liver Transpl 2019 May 3;25(5):797-806. Epub 2019 Apr 3.

Division of Nephrology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA.

On August 10, 2017, a formal policy was enacted in the United States that defined listing criteria for simultaneous liver-kidney transplantation and priority for patients who received a liver transplantation (LT) and subsequently developed significant kidney disease after LT. This article reviews and summarizes the rationale for such policies, the policies themselves, and the potential impact on LT candidates. Read More

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http://doi.wiley.com/10.1002/lt.25444
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http://dx.doi.org/10.1002/lt.25444DOI Listing
May 2019
6 Reads

Home-Based Exercise in Patients Awaiting Liver Transplantation: A Feasibility Study.

Liver Transpl 2019 Mar 11. Epub 2019 Mar 11.

Liver Transplant Unit, Queen Elizabeth University Hospitals Birmingham, Mindelsohn Way, Birmingham, B15 2TH, UK.

Background: Frailty is associated with increased mortality both pre- and post- liver transplantation [LT]. There are no standardised exercise programs, in particular home-based, in patients awaiting LT. The aim was to investigate the feasibility of a home-based exercise program [HBEP] in patients awaiting LT. Read More

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http://doi.wiley.com/10.1002/lt.25442
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http://dx.doi.org/10.1002/lt.25442DOI Listing
March 2019
3 Reads

Caval Replacement With Cadaveric External Iliac Vein in Pediatric Liver Transplant: Internal Iliac Vein as Optimal Site for Outflow Anastomosis.

Liver Transpl 2019 Mar 10. Epub 2019 Mar 10.

Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/lt.25440DOI Listing

Manipulation of lipid metabolism during normothermic machine perfusion: Effect of defatting therapies on donor liver functional recovery.

Liver Transpl 2019 Feb 28. Epub 2019 Feb 28.

Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Background: Strategies to increase steatotic donor livers' utilisation are required to tackle the mortality on the transplant waiting list. We aimed to test the efficacy of pharmacological enhancement of the lipid metabolism of human livers during ex-situ normothermic machine perfusion to promote defatting and improve the functional recovery of the organs.

Methods: Ten livers discarded because of steatosis were allocated to a defatting group that had the perfusate supplemented with a combination of drugs to enhance lipid metabolism or a control group that received perfusion fluid with vehicle only. Read More

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http://doi.wiley.com/10.1002/lt.25439
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http://dx.doi.org/10.1002/lt.25439DOI Listing
February 2019
8 Reads

The "Skinny" on Assessment and Utilization of Steatotic Liver Grafts: A Systematic Review.

Liver Transpl 2019 Mar;25(3):488-499

Department of Transplant, Mayo Clinic Florida, Jacksonville, FL.

The frequency at which steatotic deceased donor liver grafts are encountered will likely continue to increase. Utilization of liver grafts with moderate-to-severe steatosis for liver transplantation (LT) has been previously shown to be associated with increased rates of primary nonfunction and decreased recipient survival. In order to better inform clinical decision making and guide future research, critical evaluation of the literature on donor liver steatosis and posttransplantation outcome is needed. Read More

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http://dx.doi.org/10.1002/lt.25408DOI Listing

Sorafenib in Hepatopulmonary Syndrome (SHPS): A Randomized, Double-Blind Placebo-Controlled Trial.

Liver Transpl 2019 Feb 28. Epub 2019 Feb 28.

Department of Medicine, University of Arizona College of Medicine Phoenix, Phoenix, AZ.

The tyrosine kinase inhibitor sorafenib improves hepatopulmonary syndrome (HPS) in an experimental model. However, the efficacy and side effect profile in patients with HPS are unknown. We aimed to determine the effect of sorafenib on the alveolar-arterial oxygen gradient (AaPO ) at three months in patients with HPS. Read More

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http://dx.doi.org/10.1002/lt.25438DOI Listing
February 2019
1 Read

Obesity: Weighty Challenges for the Liver Transplant Community.

Liver Transpl 2019 Apr;25(4):531-532

Multi-Organ Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/lt.25437DOI Listing

Donation After Circulatory Death Liver Procurement: Time to Consider More Options?

Liver Transpl 2019 Apr;25(4):533-534

Gastroenterology Division, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/lt.25436DOI Listing
April 2019
1 Read

Application of 3-Dimensional Printing in Pediatric Living Donor Liver Transplantation: A Single-Center Experience.

Liver Transpl 2019 Feb 15. Epub 2019 Feb 15.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Three-dimensional (3D) printing has been used to support organ transplantations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D-printed liver models in pediatric living donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1002/lt.25435DOI Listing
February 2019
2 Reads

Current Knowledge, Barriers to Implementation, and Future Directions in Palliative Care for End-Stage Liver Disease.

Liver Transpl 2019 May 5;25(5):787-796. Epub 2019 Apr 5.

Division of Hepatology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

End-stage liver disease (ESLD) is associated with a high degree of morbidity and mortality as well as symptom burden. Despite this, the rate of consultation with palliative care (PC) providers remains low, and invasive procedures near the end of life are commonplace. Studies show that involvement of PC providers improves patient satisfaction, and evidence from other chronic diseases demonstrates reduced costs of care and potentially increased survival. Read More

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http://dx.doi.org/10.1002/lt.25434DOI Listing

Evolving Trends in Liver Transplant for Metabolic Liver Disease in the United States.

Liver Transpl 2019 Feb 12. Epub 2019 Feb 12.

Hillman Center for Pediatric Transplantation, University of Pittsburgh, Pittsburgh, PA.

Indications for liver transplantation (LT) in metabolic disease are evolving. We reviewed the US experience with primary LT for metabolic disease in the Scientific Registry for Transplant Recipients (October 1987 to June 2017) to determine the following: temporal changes in indications, longterm outcomes, and factors predicting survival. Patients were grouped by the presence of structural liver disease (SLD) and whether the defect was confined to the liver. Read More

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http://dx.doi.org/10.1002/lt.25433DOI Listing
February 2019
1 Read

Body Image in Liver Transplantation Recipients.

Liver Transpl 2019 May 26;25(5):712-723. Epub 2019 Mar 26.

Department of Surgery and Pediatrics, Yale University School of Medicine, New Haven, CT.

Body image (BI) concerns have been reported to play a significant role in the psychological adaptation after organ transplantation. There is a paucity of data about BI beliefs in liver transplant recipients. We report the results of a cross-sectional study of 177 liver transplant recipients for whom we assessed BI, anxiety, depression, and quality of life (QOL) using validated instruments. Read More

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http://dx.doi.org/10.1002/lt.25432DOI Listing
May 2019
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High Burden of Subclinical Cardiovascular Target Organ Damage After Pediatric Liver Transplantation.

Liver Transpl 2019 May 25;25(5):752-762. Epub 2019 Mar 25.

Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.

Cardiovascular (CV) events account for 8%-13% of deaths after liver transplantation (LT) in adulthood. Although CV risk factors (RFs) are present, little is known about the prevalence of subclinical CV target organ damage (TOD) in children after LT. The aim of this prospective observational study was to assess the prevalence of subclinical CV TOD in children after LT and to identify RFs contributing to CV damage as potential targets for clinical intervention. Read More

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http://dx.doi.org/10.1002/lt.25431DOI Listing
May 2019
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Use of Steatotic Grafts in Liver Transplantation: Current Status.

Liver Transpl 2019 May 5;25(5):771-786. Epub 2019 Apr 5.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

In the field of liver transplantation, the demand for adequate allografts greatly exceeds the supply. Therefore, expanding the donor pool to match the growing demand is mandatory. The present review summarizes current knowledge of the pathophysiology of ischemia/reperfusion injury in steatotic grafts, together with recent pharmacological approaches aimed at maximizing the utilization of these livers for transplantation. Read More

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http://dx.doi.org/10.1002/lt.25430DOI Listing
May 2019
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Liver Transplant in Colombia.

Liver Transpl 2019 Apr 14;25(4):658-663. Epub 2019 Mar 14.

Liver Transplant Program, Hospital Pablo Tobon Uribe, University of Antioquia, Medellin, Colombia.

Liver transplantation began in Colombia in 1979. It is one of the most active countries in this field in Latin America but has faced problems with the regulation and appropriate management of solid organ transplantations, including transplant tourism, which is a worldwide problem. There is a well-structured donation and transplant network regulated by the government in all the stages of the process. Read More

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http://dx.doi.org/10.1002/lt.25427DOI Listing

Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.

Liver Transpl 2019 Apr 15;25(4):610-626. Epub 2019 Mar 15.

Department of Surgery, Duke University Medical Center, Durham, NC.

Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP. We hypothesized that there is a metabolism-dependent accumulation of damage-associated molecular patterns (DAMPs) and inflammatory cytokines during MP and that these molecules provoke inflammation in the graft. Read More

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http://dx.doi.org/10.1002/lt.25429DOI Listing
April 2019
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Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver-Kidney Transplants.

Liver Transpl 2019 Apr 4;25(4):667-668. Epub 2019 Mar 4.

Divisions of Transplant, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

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http://dx.doi.org/10.1002/lt.25428DOI Listing
April 2019
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Outcomes After Listing for Liver Transplant in Patients With Acute-on-Chronic Liver Failure: The Multicenter North American Consortium for the Study of End-Stage Liver Disease Experience.

Liver Transpl 2019 Apr 24;25(4):571-579. Epub 2019 Mar 24.

University of Pennsylvania, Philadelphia, PA.

Acute-on-chronic liver failure (ACLF) characterized with ≥2 extrahepatic organ failures in cirrhosis carries a high mortality. Outcomes of patients listed for liver transplantation (LT) after ACLF and after LT are largely unknown. The North American Consortium for the Study of End-Stage Liver Disease prospectively enrolled 2793 nonelectively hospitalized patients with cirrhosis; 768 were listed for LT. Read More

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http://dx.doi.org/10.1002/lt.25426DOI Listing
April 2019
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