1,068,114 results match your criteria Liver Transplantation[Journal]
Diabetes Metab Res Rev 2018 Dec 17:e3118. Epub 2018 Dec 17.
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
Apolipoprotein CIII (ApoCIII), a small protein that resides on the surface of lipoprotein particles, is a key regulator of triglyceride metabolism. The inhibition of lipoprotein lipase (LPL), the increased assembly and secretion of very low-density lipoproteins (VLDL) and the decreased reuptake of triglyceride-rich lipoproteins (TRLs) by the liver are mechanisms associating elevated serum ApoCIII levels and hypertriglyceridemia. ApoCIII concentration is high in individuals with diabetes mellitus indicating a possible positive correlation with impairment of glucose metabolism. Read More
Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.
Universidade Federal do Rio de Janeiro, School of Physical Education and Sports, Rio de Janeiro, Brazil.
The purpose of this study was to analyze and compare heart rate (HR), heart rate variability (HRV), and blood pressure (BP) responses during and after circuit resistance training with 1 min. (CIR1) vs. 2 min. Read More
Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.
Z Wang, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. Read More
Biomed Pharmacother 2018 Dec 14;110:869-877. Epub 2018 Dec 14.
HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, Nigeria. Electronic address:
Dipeptidyl peptidase-4 (DPP-4) inhibition has been shown to exert beneficial effects against insulin resistance (IR) and type 2 diabetes. Combined oral contraceptive (COC) treatment is associated with impaired glucose and lipid metabolism but the mechanisms are elusive. We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthine oxidase (XO) /uric acid-dependent pathway. Read More
Biomed Pharmacother 2018 Dec 14;110:844-849. Epub 2018 Dec 14.
The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310023, Zhejiang, China. Electronic address:
Background Hyperuricemia is a recognised risk factor for the development of nonalcoholic fatty liver disease (NAFLD). This study aims to investigate the therapeutic effect of resveratrol (RES) on the treatment of hyperuricemia-related NAFLD in rats and the underlying mechanisms. Methods NAFLD with hyperuricemia was induced in rats using high-yeast high-fat diet containing potassium oxonate. Read More
Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Semeiotica Medica, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum - University of Bologna, Via Massarenti 9, 40128, Bologna, Italy. Electronic address:
Background & Aims: The electrocardiographic QT interval is frequently prolonged in patients with cirrhosis. Acute gastrointestinal bleeding further prolongs corrected QT (QTc) in patients with cirrhosis, which has been associated with increased risk of death within 6 weeks. We aimed to confirm these findings and develop a mortality risk index that incorporates QTc. Read More
Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.
Background And Aims: Little is known about the prevalence or treatment of pruritus associated with primary biliary cholangitis (PBC). We analyzed data from patients with PBC recruited from all clinical centers in the United Kingdom (UK) to characterize the prevalence, severity, progression, and treatment of pruritus.
Methods: We performed cross-sectional and longitudinal study of patients in the UK-PBC cohort to assess trajectories of pruritus. Read More
Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.
University of Washington, School of Pharmacy, Department of Pharmaceutics, Seattle, WA, USA. Electronic address:
The importance of uptake transporters in determining drug disposition is increasingly appreciated. While the focus of regulatory agencies worldwide has been on the hepatic organic anion transporting polypeptides (OATPs) 1B1 and 1B3, there is another isoform of the OATP sub-family, OATP2B1, which should be considered equally relevant. Unlike the other members of the OATP sub-family, OATP2B1 is expressed in multiple organs in humans, including in the intestine and the liver. Read More
Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.
Aix Marseille Université, INSERM, INRA, C2VN, Marseille, France; Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-, HM, Marseille, France.. Electronic address:
KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT. Read More
Fish Shellfish Immunol 2018 Dec 14. Epub 2018 Dec 14.
Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha, 410128, China; Collaborative Innovation Center for Efficient and Health Production of Fisheries in Hunan Province, Changde, Hunan, 415000, China. Electronic address:
The grass carp reovirus (GCRV) has been shown to cause lethal infections in the grass carp Ctenopharyngodon idella (C. idella). In order to investigate the immune response to GCRV infection, the full-length cDNA sequences of coagulation factor VIII (CiFVIII) and plasminogen (CiPLG) from C. Read More
PLoS One 2018 17;13(12):e0209104. Epub 2018 Dec 17.
Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of human equilibrative nucleoside transporter 1 (hENT1) is regarded as a potential predictive biomarker for a gemcitabine response in some cancers. This study was conducted to investigate the association between hENT1 expression and the effects of gemcitabine on BTC cell lines and on patients with advanced BTC receiving gemcitabine-based chemotherapy. Read More
PLoS One 2018 17;13(12):e0209162. Epub 2018 Dec 17.
Department of Regenerative Medicine and Biomedical Engineering, Faculty of Medicine, Saga University, Saga, Japan.
A major challenge in cardiac tissue engineering is the host's immune response to artificial materials. To overcome this problem, we established a scaffold-free system for assembling cell constructs using an automated Bio-3D printer. This printer has previously been used to fabricate other three-dimensional (3D) constructs, including liver, blood vessels, and cartilage. Read More
PLoS One 2018 17;13(12):e0209164. Epub 2018 Dec 17.
Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Background: Patients with end-stage liver disease frequently experience acute kidney injury (AKI) after living donor liver transplantation (LDLT). Serum levels of brain natriuretic peptide (BNP) have increasingly been accepted as a predictor of AKI in clinical settings. This study investigated the predictive role of intraoperative BNP levels in the early development of AKI after LDLT. Read More
PLoS One 2018 17;13(12):e0209364. Epub 2018 Dec 17.
Laboratorio de Genética Molecular Humana, Facultad de Medicina/Instituto de Investigación en Discapacidades Neurológicas (IDINE), Universidad de Castilla-La Mancha, Albacete, Spain.
Myocilin is an extracellular glycoprotein with a poorly understood biological function and typically known because of its association with glaucoma. In this study, we analyzed the expression and biological activity of human myocilin in some non-ocular tissues. Western immunoblot showed the presence of myocilin in blood plasma as well as in liver and lymphoid tissues (thymus and lymph node). Read More
PLoS Genet 2018 Dec 17;14(12):e1007837. Epub 2018 Dec 17.
Biostatistics Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Read More
Crit Care Med 2019 Jan;47(1):123-124
Department of Medicine, Emory University School of Medicine, Atlanta, GA Departments of Medicine and Surgery, Emory University School of Medicine, Atlanta, GA.
Eur J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Objective: Few studies carried out more than 20 years ago have evaluated spontaneous bacterial peritonitis (SBP) recurrence in patients receiving secondary antibiotic prophylaxis. These studies reported a 1-year recurrence rate of 20-26%. Changes in the bacteriology of SBP over the last few years might have negative effects on secondary prophylaxis. Read More
Alcohol Res 2018 ;39(1):57-76
Richard W. Wilsnack, Ph.D., is a professor emeritus in the Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota. Sharon C. Wilsnack, Ph.D., is the Chester Fritz Distinguished Professor in the Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota. Gerhard Gmel, Ph.D., is a professor, University of Lausanne, and is affiliated with the Alcohol Treatment Center, University of Lausanne Hospital, Lausanne, Switzerland. He is also an invited professor, University of the West of England, Bristol, United Kingdom. Lori Wolfgang Kantor, M.A., is a science writer at CSR, Incorporated.
Just as binge drinking rates differ for men and women, the predictors and consequences of binge drinking vary by gender as well. This article examines these differences and how binge drinking definitions and research samples and methods may influence findings. It also describes the relationship between age and binge drinking among men and women, and how drinking culture and environment affect this relationship. Read More
Xenobiotica 2018 Dec 17:1-19. Epub 2018 Dec 17.
a Department of Endocrinology , Seventh People's Hospital of Shanghai University of TCM , Shanghai 200137 , China.
1. Catalpol possesses numerous pharmacological activities, and however, little data available for the effects of catalpol on the activity of human liver cytochrome P450 (CYP) enzymes. 2. Read More
Mod Rheumatol 2018 Dec 17:1-16. Epub 2018 Dec 17.
c Division of Rheumatology, Department of Internal Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.
Objectives Comorbidities and conventional risk factors influence the prognosis of patients with rheumatoid arthritis (RA). We investigated whether liver fibrosis burden is associated with all-cause mortality in patients with RA. Methods A total of 2812 patients with RA were retrospectively selected and reviewed. Read More
J Morphol 2019 Jan;280(1):133-148
School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL, USA.
Levantine scraper, Capoeta damascina is a candidate species for future stock assessments, conservation studies, and hatchery efforts. Herein, we documented embryonic and early larval development, from egg activation to the exogenous feeding period, using morphological and histological landmarks. Embryos were obtained by in vitro fertilization from hormonally induced wild-caught broodstock, and subsequent development was monitored at temperatures coinciding with native conditions. Read More
Transpl Int 2018 Dec 17. Epub 2018 Dec 17.
Research Institute of St. Mary's Hospital, Kurume, Japan.
Expansion of the liver transplantation indication criteria for patients with hepatocellular carcinoma (HCC) has long been debated. Here we propose new, expanded living-donor liver transplantation (LDLT) criteria for HCC patients based on a retrospective data analysis of the Japanese nationwide survey. A total of 965 HCC patients undergoing LDLT were included, 301 (31%) of whom were beyond the Milan criteria. Read More
Vet Clin Pathol 2018 Dec 17. Epub 2018 Dec 17.
University of Wisconsin Veterinary Diagnostic Laboratory-Barron, Barron, Wisconsin.
J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.
Department of General Surgery, Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hepatocellular carcinoma is one of the most prevalent and fatal cancers. Studying the long noncoding RNA (lncRNA) alterations in hepatocellular carcinoma may lead to new therapeutic strategies. We checked whether there were correlations between The Cancer Genome Atlas expression profiles of the differentially expressed lncRNAs and their DNA methylation status or the copy number variations for hepatocellular carcinoma. Read More
Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8431-8437
Department of Medical Technology, Xi'an Medical University, Xi'an, China.
Objective: To explore the expressions of miR-132 in patients with chronic hepatitis B, posthepatitic cirrhosis and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and to investigate its possible mechanism affecting the function of the body.
Patients And Methods: Among 125 patients with HBV, there were 44 cases of chronic hepatitis, 42 cases of liver cirrhosis and 39 cases of liver cancer. Their liver function and HBV-deoxyribonucleic acid (HBV-DNA) viral load as well as the expressions of micro ribonucleic acid-132 (miR-132), phosphoinositide 3-kinase (PI3K), phosphorylated-protein kinase B (p-Akt) and hepatitis B X protein (HBx), were detected. Read More
Mod Rheumatol 2018 Dec 17:1-13. Epub 2018 Dec 17.
b Department of Pediatric Rheumatology , Ümraniye Training and Research Hospital , Ümraniye/İstanbul , Turkey.
Background: Little is known about the long-term efficacy and safety of canakinumab in paediatric FMF patients.
Aim: To present the single centre experience of colchicine-resistant paediatric-onset FMF patients who were treated with canakinumab by off-label use since 2012.
Methods: The hospital files of 15 children who used canakinumab were retrospectively evaluated. Read More
Nano Lett 2018 Dec 17. Epub 2018 Dec 17.
Afterglow imaging through the collection of persistent luminescence after the stopping of light excitation holds enormous promise for advanced biomedical uses. However, efficient near-infrared (NIR)-emitting afterglow luminescent materials and probes (particularly the organic and polymeric ones) are still very limited, and their in-depth biomedical applications such as precise image-guided cancer surgery are rarely reported. Here, we design and synthesize a NIR afterglow luminescent nanoparticle with aggregation-induced emission (AIE) characteristics (named AGL AIE dots). Read More
IUBMB Life 2018 Dec 17. Epub 2018 Dec 17.
Ursuline College, Department of Biology, 2550 Lander Rd Pepper Pike, Ohio 44124.
Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis of neurological-related vitamin E deficient diseases point to compromised neuronal integrity and function, underlining the critical need to understand vitamin E regulation in the CNS. Read More
Pharmacoepidemiol Drug Saf 2018 Dec 17. Epub 2018 Dec 17.
Research Section, Uppsala Monitoring Centre, Uppsala, Sweden.
Purpose: Drug-induced aseptic meningitis (DIAM) is an inflammation of the membranes of the central nervous system caused by certain medications. It is a rare clinical entity whose risk factors are not yet fully elucidated. A local pattern of disproportionality within a global database of suspected adverse drug reactions (ADRs) revealed an increased reporting of aseptic meningitis and amoxicillin-clavulanic acid (AC) in males. Read More
Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Background: Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers to determine prognosis and select targeted therapies are urgently needed for patients with HCC. This study aimed to elucidate the role of UCK2 in HCC prognosis and tumor progression. Read More
Hepatology 2018 Dec 17. Epub 2018 Dec 17.
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Jacksonville, FL.
The global prevalence of hepatocellular cancer (HCC) underscores the need for effective strategies that can reduce the burden and impact of this disease. The increase in the incidence and mortality from HCC in the United States and Europe further emphasize the need for early detection to identify tumors at an early stage and amenable to curative treatments Screening and surveillance for HCC in patients with cirrhosis has been shown to improve survival. Guidelines from major professional societies encourage surveillance for HCC in patients with cirrhosis, advanced fibrosis or high risk hepatitis B virus (HBV) infection. Read More
Histol Histopathol 2018 Dec 17:18075. Epub 2018 Dec 17.
Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas - SP, Brazil.
Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands it is often prescribed in cases of severe acne treatment. The treatment for the average patient is carried out during two to ten months. This study was designed to investigate liver structure, hepatic enzyme levels and the stress oxidative parameter after isotretinoin treatment during a similar period and using the dosages of 1 mg/kg and another one of 10 mg/kg in young male Wistar rats. Read More
Med Sci Monit 2018 Dec 17;24:9151-9165. Epub 2018 Dec 17.
Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, Hebei, China (mainland).
BACKGROUND Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA, which has also been identiﬁed in somatic tissues, and aberrant expression of piRNAs in tumor tissues may be implicated in carcinogenesis. piR-823 is increased in liver cirrhosis and hepatocellular carcinoma (HCC). However, there is no report on the function of piR-823 in hepatic stellate cells (HSCs) activation during hepatic fibrosis. Read More
Recent Pat Biotechnol 2018 Dec 16. Epub 2018 Dec 16.
Department of Radiology, Weill Medical College of Cornell University, New York. United States.
Background: Quantitative susceptibility mapping (QSM) depicts biodistributions of tissue magnetic susceptibility sources, including endogenous iron and calcifications, as well as exogenous paramagnetic contrast agents and probes. When comparing QSM with simple susceptibility weighted MRI, QSM eliminates blooming artifacts and shows reproducible tissue susceptibility maps independent of field strength and scanner manufacturer over a broad range of image acquisition parameters. For patient care, QSM promises to inform diagnosis, guide surgery, gauge medication, and monitor drug delivery. Read More
Vet Pathol 2018 Dec 16:300985818813099. Epub 2018 Dec 16.
2 The Raptor Center, University of Minnesota, St. Paul, MN, USA.
Lead toxicity due to ingestion of spent ammunition is an ongoing cause of mortality in bald eagles. While gross and histologic lesions of lead intoxication have been described in a few individuals of this species, the prevalence of lesions is underreported. A retrospective study of 93 bald eagles with severe lead intoxication was performed to describe the associated lesions and their prevalence and to compare the lesions with blood, liver, kidney, and/or bone lead concentrations. Read More
J Biol Regul Homeost Agents 2018 Dec 17;33(1). Epub 2018 Dec 17.
Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore, Pakistan.
Obesity is an epidemic issue associated with low-grade inflammation and in most of the cases with poor iron condition that influences nearly every community. The present research experiment was designed to inspect the consequences of obesity on the micro architecture of heart and kidney tissues as well as on the expression of mRNA of some hepatic genes like Hepcidin, Transferrin and TNF-α in association with their role in iron regulation and proinflammatory responses in the body. Two tentative groups of (each supplied with different proportions of fat in their food) and one control group were analysed. Read More
Mol Oncol 2018 Dec 16. Epub 2018 Dec 16.
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health; Clinical Medicine Research Center of Hepatic Surgery in Hubei Province, Wuhan, 430030, P.R.China.
Fam134b (JK-1, RETREG1) was first identified as an oncogene in esophageal squamous cell carcinoma. However, the roles of FAM134B during tumorigenesis of hepatocellular carcinoma (HCC) and in epithelial-to-mesenchymal transition (EMT) were previously unclear. In this study, we investigated the function of FAM134B in HCC and the related tumorigenesis mechanisms, as well as how FAM134B induces EMT. Read More
J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.
Department of Urinary Surgery, Shanghai Tongji Hospital, Shanghai, P.R. China.
LnRNA-NEF has characterized functionality only in liver cancer. In the present study, we observed that plasma lnRNA-NEF was downregulated, while plasma transforming growth factor-β1 (TGF-β1) was upregulated in patients with early-stage prostate carcinoma (PC) than in healthy controls. The levels of plasma lnRNA-NEF and plasma TGF-β1 were inversely correlated in patients with PC but not in healthy controls. Read More
Anim Sci J 2018 Dec 16. Epub 2018 Dec 16.
Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.
Thirty-two 15-day old broiler chicks (Chunky strain ROSS 308) were randomly divided into four treatments in a 2 × 2 factorial design. The main factors were diet (basal diet or basal diet supplemented with 0.15% astaxanthin-rich dried cell powder (Panaferd-P [astaxanthin 30 ppm]) and ambient temperature (thermo-neutral [25 ± 1°C] or high [35 ± 1°C for 6 hr]). Read More
Phytother Res 2018 Dec 16. Epub 2018 Dec 16.
Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000, Novi Sad, Serbia.
Pycnogenol® (PYC) has already being used as a food supplement and herbal medicine due to its potent antioxidant properties. The aim of the present study was to examine the protective effect of PYC on acetaminophen-induced acute liver injury in rats. The effect of PYC on acetaminophen-induced hepatotoxicity in rats was examined by determining biochemical parameters, in vitro antioxidant activity, histological assessment, and oxidative status in liver homogenates. Read More
Environ Toxicol Chem 2018 Dec 17. Epub 2018 Dec 17.
Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, USA.
The Deepwater Horizon (DWH) oil spill resulted in the release of over 640 million liters of crude oil into the Gulf of Mexico (GOM), affecting over 2,000 kilometers of shoreline, including estuaries that serve as important habitats and nurseries for aquatic species. Cyprinodon variegatus (sheepshead minnow; SHM) are small-bodied fish that inhabit northern GOM estuaries, are easily adaptable to laboratory conditions, and are commonly used in toxicological assessment studies. The purpose of this study was to determine the somatic, reproductive, and developmental effects of an environmentally relevant polycyclic aromatic hydrocarbon (PAH) mixture, the oil high-energy water accommodated fraction (HEWAF), on experimentally exposed SHM (F ), as well as two generations of offspring (F and F ) without additional exposure. Read More
Hepatology 2018 Dec 16. Epub 2018 Dec 16.
National Institute for Health Research Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, and the University of Birmingham.
Non-alcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general population, and cirrhosis secondary to Non-Alcoholic Steatohepatitis (NASH) is predicted to become the leading cause of liver transplantation and yet there is a lack of effective licensed treatments. There is a close relationship between insulin resistance and NAFLD, with the prevalence of NAFLD being five-fold higher in patients with diabetes compared to patients without. Insulin resistance is implicated both in the pathogenesis of NAFLD and in disease progression from steatosis to NASH. Read More
Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
Introduction: Despite the widespread use of transient elastography for non-invasive assessment of liver fibrosis, the optimal cut-off liver stiffness measurement (LSM) values remain unclear. This study aimed to validate the optimal cut-off LSM values for significant fibrosis and cirrhosis in patients with chronic liver disease (CLD).
Methods: Prospective multicentre data of CLD patients who underwent paired liver biopsy and LSM was analysed to determine the optimal cut-off LSM values for predicting significant fibrosis (METAVIR F ≥ 2) and cirrhosis (METAVIR F4). Read More
Hepatol Commun 2018 Dec 5;2(12):1601-1609. Epub 2018 Oct 5.
Department of Internal Medicine 1 J.W. Goethe-University Hospital Frankfurt Germany.
Platelets participate in the development of liver fibrosis in animal models, but little is known about the benefit of antiplatelet agents in preventing liver fibrosis in humans. We therefore explored the relationship between the use of antiplatelet agents and liver fibrosis in a prospective cohort study of patients at high risk of liver fibrosis and cardiovascular events. Consecutive patients undergoing elective coronary angiography at the University Hospital Frankfurt were prospectively included in the present study. Read More
Hepatol Commun 2018 Dec 27;2(12):1583-1600. Epub 2018 Sep 27.
Division of Digestive and Liver Diseases, Department of Medicine Cedars Sinai Medical Center Los Angeles CA.
Prohibitin1 () is a mitochondrial chaperone with diverse functions that include cell proliferation, apoptosis, and mitochondrial homoeostasis. Liver-specific knockout (KO) mice develop spontaneous injury and hepatocellular carcinoma (HCC). Our previous work demonstrated that PHB1 negatively regulates the H19-insulin-like growth factor 2 (IGF2)-H19-IGF2 axis signaling pathway and E-box activity in hepatocytes and HCC cells. Read More
Hepatol Commun 2018 Dec 1;2(12):1567-1582. Epub 2018 Oct 1.
Laboratory of Metabolism National Cancer Institute, National Institutes of Health Bethesda MD.
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an association between altered bile acid (BA) metabolism, down-regulation of farnesoid X receptor (FXR), which is a master regulator of BA metabolism, and hepatocarcinogenesis has been documented. While global FXR deficiency in mice results in spontaneous HCC with aging, the contribution of tissue-specific FXR deficiency to hepatocarcinogenesis remains unclear. In this study, the prevalence of hepatic tumors, expression of genes related to tumorigenesis, and serum/liver BA levels were compared among male whole-body -null, hepatocyte-specific -null (), and enterocyte-specific -null () mice at the age of 3, 14, and 20 months. Read More
Hepatol Commun 2018 Dec 23;2(12):1550-1566. Epub 2018 Oct 23.
Amsterdam UMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism Amsterdam the Netherlands.
Cholestasis-induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)-mediated transcriptional down-regulation of the bile acid importer Na-taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum (ER) stress. However, whether ER stress affects bile acid uptake is largely unknown. Here, we investigated the role of ER stress on the regulation and function of the bile acid transporter NTCP. Read More
Hepatol Commun 2018 Dec 10;2(12):1533-1549. Epub 2018 Oct 10.
Sorbonne Université, INSERM Centre de Recherche Saint-Antoine (CRSA), and Institute of Cardiometabolism and Nutrition (ICAN) Paris France.
The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the potential impact of environmental and genetic factors on the development of CF-related cholangiopathy in mice. Cystic fibrosis transmembrane conductance regulator () mice and littermates in a congenic C57BL/6J background were fed a high medium-chain triglyceride (MCT) diet. Read More
Hepatol Commun 2018 Dec 29;2(12):1513-1532. Epub 2018 Oct 29.
Department of Metabolic Health Research Netherlands Organization for Applied Scientific Research Leiden The Netherlands.
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventions in the process of NASH/fibrosis. We investigated the representation of molecular disease patterns characteristic for human NASH in high-fat diet (HFD)-fed Ldlr-/-.Leiden mice and studied the effects of obeticholic acid (OCA) on these disease profiles. Read More
Hepatol Commun 2018 Dec 1;2(12):1493-1512. Epub 2018 Oct 1.
Division of Pediatric Gastroenterology and Hepatology Mayo Clinic Rochester MN.
With the epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common pediatric liver disease. The influence of a perinatal obesity-inducing diet (OID) on the development and progression of NAFLD in offspring is important but incompletely studied. Hence, we fed breeding pairs of C57BL/6J mice during gestation and lactation (perinatally) either chow or an OID rich in fat, fructose, and cholesterol (FFC). Read More