4,944 results match your criteria Liver Transplantation[Journal]


Application of three-dimensional printing in pediatric living donor liver transplantation: a single-center experience.

Liver Transpl 2019 Feb 15. Epub 2019 Feb 15.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.

Background & Aims: Three-dimensional (3D) printing has been used to support organ translations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D printed liver models in pediatric living donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1002/lt.25435DOI Listing
February 2019

Current Knowledge, Barriers to Implementation, and Future Directions in Palliative Care for End Stage Liver Disease.

Liver Transpl 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

End stage liver disease (ESLD) is increasing in incidence(1,2), resulting in a greater burden on the healthcare system, which is estimated to cost over 2 billion United States dollars each year.(3) Unfortunately, many of these expenditures fail to meaningfully improve or prolong life for patients.(4) In addition to these costs, patients with ESLD suffer a high burden of symptoms and invasive procedures, even when death may be imminent. Read More

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http://dx.doi.org/10.1002/lt.25434DOI Listing
February 2019

Evolving trends in liver transplant for metabolic liver disease in the United States.

Liver Transpl 2019 Feb 12. Epub 2019 Feb 12.

Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, USA.

Rationale: Indications for liver transplantation (LT) in metabolic disease are evolving. We reviewed the US experience with primary LT for metabolic disease in the Scientific Registry for Transplant Recipients (October 1987 to June 2017) to determine: 1. Temporal changes in indications, 2. Read More

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http://dx.doi.org/10.1002/lt.25433DOI Listing
February 2019

Body Image in Liver transplant recipients.

Liver Transpl 2019 Feb 11. Epub 2019 Feb 11.

Department of Surgery and Pediatrics, Yale University School of Medicine.

Body Image (BI) concerns have been reported to play a significant role in the psychological adaptation post organ transplantation. There is a paucity of data about BI beliefs in liver transplant recipients. We report the results of a cross-sectional study of 177 liver transplant recipients in which we assessed BI, anxiety, depression and quality of life using validated instruments. Read More

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http://dx.doi.org/10.1002/lt.25432DOI Listing
February 2019
1 Read

High Burden of Subclinical Cardiovascular Target Organ Damage After Pediatric Liver Transplantation.

Liver Transpl 2019 Feb 11. Epub 2019 Feb 11.

Interdisciplinary and Experimental Transplantation Medicine, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.

Cardiovascular (CV) events account for 8% to 13% of deaths after liver transplantation (LT) in adulthood. Although CV risk factors are present, little is known about the prevalence of subclinical CV target organ damage in children after LT. The aim of this prospective observational study was to assess the prevalence of subclinical CV target organ damage in children after LT and to identify risk factors contributing to CV damage as potential targets for clinical intervention. Read More

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http://dx.doi.org/10.1002/lt.25431DOI Listing
February 2019
1 Read

Use of steatotic grafts in liver transplantation: Current status.

Liver Transpl 2019 Feb 10. Epub 2019 Feb 10.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

In the field of liver transplantation, the demand for adequate allografts greatly exceeds supply. Therefore, expanding the donor pool to match the growing demand is mandatory. The present review summarizes current knowledge of the pathophysiology of ischemia and reperfusion injury in steatotic grafts, together with recent pharmacological approaches aimed at maximizing the utilization of these livers for transplantation. Read More

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http://dx.doi.org/10.1002/lt.25430DOI Listing
February 2019

Liver Transplant in Colombia.

Liver Transpl 2019 Feb 8. Epub 2019 Feb 8.

Liver Transplant Program, Hospital Pablo Tobon Uribe, Professor University of Antioquia, Gastrohepatology group member, University of Antioquia, Medellin, Colombia.

Liver transplants (LTs) began in Colombia in 1979. Between 1999 and 2017, 3,081 LTs were performed, occupying fourth place in Latin America in 2017 after Brazil, Argentina, and Uruguay, with a rate of 5.6 LTs per million population (pmp). Read More

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http://dx.doi.org/10.1002/lt.25427DOI Listing
February 2019

DAMPs induce inflammatory injury during machine preservation of the liver: Potential targets to enhance a promising technology.

Liver Transpl 2019 Feb 7. Epub 2019 Feb 7.

Duke University Medical Center, Department of Surgery, Durham, NC.

Introduction: Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP. We hypothesized that there is a metabolism-dependent accumulation of damage-associated molecular patterns (DAMPs) and inflammatory cytokines during MP, and that these molecules provoke inflammation in the graft. Read More

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http://dx.doi.org/10.1002/lt.25429DOI Listing
February 2019
2 Reads

Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver Kidney Transplants: Thymoglobulin Induction Is Not Harmful.

Liver Transpl 2019 Feb 7. Epub 2019 Feb 7.

Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

We read with great interest the article by AbdulRahim et al. , which studied the impact of induction therapy on patient survival following combined liver-kidney transplantation (CLKT). The article included national data from 2002-2016 analyzing 4722 CLKTs: (i) no-induction (n=2333), (ii) IL2RA induction (n=1558), and (iii) r-ATG induction (n=831). Read More

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http://dx.doi.org/10.1002/lt.25428DOI Listing
February 2019

Outcomes after Listing for Liver Transplant in Patients with Acute-on-Chronic Liver Failure (ACLF): The Multicenter NACSELD Experience.

Liver Transpl 2019 Feb 5. Epub 2019 Feb 5.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Acute-on-Chronic Liver Failure (ACLF) characterized with ≥2 extra-hepatic organ failures in cirrhosis carries a high mortality. Outcomes of patients listed for liver transplant (LT) after ACLF and after LT are largely unknown. NACSELD (North American Consortium for the Study of End-Stage Liver Disease) prospectively enrolled 2,793 non-electively hospitalized patients with cirrhosis; 768 were LT-listed. Read More

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http://dx.doi.org/10.1002/lt.25426DOI Listing
February 2019
2 Reads

Improved Graft Survival after Liver Transplantation for Recipients with Hepatitis C in the Direct-acting Antiviral Era.

Liver Transpl 2019 Feb 4. Epub 2019 Feb 4.

Center for Liver Diseases, The University of Chicago Medicine, Chicago, IL, USA.

Background: Highly effective direct acting antiviral (DAA) therapy has transformed outcomes of liver transplantation in HCV patients. We examined longer-term outcomes in HCV-positive recipients in the DAA era.

Methods: We analyzed the Scientific Registry of Transplant Recipients (SRTR) for primary adult, single organ, non-fulminant liver transplant recipients in the US from January 1, 2008, to June 30, 2018. Read More

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http://dx.doi.org/10.1002/lt.25424DOI Listing
February 2019
1 Read

Surgical aspects of liver transplantation and domino liver transplantation in maple syrup urine disease: analysis of 15 donor / recipient pairs.

Liver Transpl 2019 Feb 3. Epub 2019 Feb 3.

Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Liver transplantation (LT) has been shown to be a feasible treatment in patients with severe forms of maple syrup urine disease (MSUD). Due to a sufficient extrahepatic enzyme activity in non-MSUD individuals, the organ of MSUD patients can be used as domino graft. We performed a retrospective data collection of all LTs for MSUD carried out at the University Medical Center Hamburg-Eppendorf (2016-2018). Read More

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http://doi.wiley.com/10.1002/lt.25423
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http://dx.doi.org/10.1002/lt.25423DOI Listing
February 2019
3 Reads
4.241 Impact Factor

A Simple Measure of Hepatocellular Carcinoma Burden Predicts Tumor Recurrence after Liver Transplantation: The RH-IML Classification.

Liver Transpl 2019 Jan 31. Epub 2019 Jan 31.

University of Washington, C-LIFE (Center for Liver Investigation Fostering discovEry), Seattle, WA, USA.

Risk of post liver transplant (LT) recurrent HCC (rHCC) depends on pre-LT HCC burden, tumor behavior, and response to locoregional therapy (LRT). In December 2017, LT priority for HCC was expanded to select patients outside the Milan Criteria who respond to LRT.

Aims: To 1) Develop a novel, objective measure of pre-LT HCC burden [model of Recurrent HCC - Initial, Maximum, Last; RH-IML], incorporating tumor behavior over time; and 2) Apply RH-IML to model post-LT rHCC. Read More

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http://dx.doi.org/10.1002/lt.25422DOI Listing
January 2019

Reply.

Liver Transpl 2019 Feb;25(2):344-345

Department of Medicine I, Department of Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/lt.25392DOI Listing
February 2019

Animal model simulation for training with split-liver transplants.

Authors:
Jonathan Fryer

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

Surgery and Organ Transplantation, Chicago, Illinois, United States.

Split liver transplantation is a strategy that enhances the availability of organ transplants (1)by potentially providing liver transplants for 2 patients from a single deceased donor (2). However, because of its complexity, most programs have not embraced this strategy. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/lt.25418DOI Listing
January 2019

Neurological Complications Occurring after Liver Transplantation: Role of Risk Factors, Hepatic Encephalopathy, and Acute (on Chronic) Brain Injury.

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

Sorbonne Université, Brain Liver Pitié-Salpêtrière (BLIPS) Study Group, INSERM, Centre de recherche Saint-Antoine, Maladies métaboliques, biliaires et fibro-inflammatoire du foie, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière-Charles Foix, Service d'hépato-gastroentérologie, Unité de Soins Intensifs d'Hépato-gastroentérologie, Paris, France.

Orthotopic liver transplantation (LT) remains the only way to definitively cure patients with the most severe liver diseases. Since the survival rate is now fairly high, important questions about neurological sequelae or quality of life after LT have emerged. Indeed, LT represents a peculiar situation because up to 30% of patients present with neurological symptoms after LT compared with only 4% after cardiac transplant and 0. Read More

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http://dx.doi.org/10.1002/lt.25420DOI Listing
January 2019
1 Read

A multi-disciplinary approach to pre and post-transplant management of cystic fibrosis associated liver disease.

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Approximately 5 to 10% of patients with cystic fibrosis (CF) will develop advanced liver disease with portal hypertension, representing the 3rd leading cause of death among patients with CF. CF liver disease (CFLD) represents the most significant risk to patient mortality second only to pulmonary or lung transplant complications in patients with CF. Currently there is no medical therapy to treat or reverse CFLD. Read More

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http://dx.doi.org/10.1002/lt.25421DOI Listing
January 2019
1 Read

Liver Transplantation in France.

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

University Paris Diderot, Paris, France.

In France, the main indications for liver transplantation are hepatocellular carcinoma (HCC) and alcoholic cirrhosis. The number of candidates for decompensated hepatitis C virus (HCV)-related cirrhosis has markedly decreased since the advent of direct antiviral agents. Non-alcoholic steatohepatitis represents a lower proportion of candidates as compared to the United States. Read More

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http://dx.doi.org/10.1002/lt.25419DOI Listing
January 2019
2 Reads

Marijuana Consumption in Liver Transplant Recipients.

Liver Transpl 2019 Jan 28. Epub 2019 Jan 28.

Department of Surgery, Division of Abdominal Transplant Surgery, The University of North Carolina, Chapel Hill, North Carolina, United States.

Marijuana is legalized for either medical or recreational use in over half of the United States and in Canada, but many transplant centers will not list patients who are using marijuana. However, the effect of marijuana on transplant outcomes remains unclear. Thus, we performed a retrospective analysis of all adult (≥18 years old) liver transplant patients treated at our center between 2007 and 2017. Read More

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http://dx.doi.org/10.1002/lt.25417DOI Listing
January 2019

An Atypical Biliary Fistula In A Liver Transplant Recipient.

Liver Transpl 2019 Jan 28. Epub 2019 Jan 28.

Division of Hepatology, Baylor University Medical Center, Dallas, TX.

A 55-years-old Caucasian male presented with chest pain, dyspnea and hypotension four-months after simultaneous liver and kidney transplantation. His post-transplant course was complicated with only one episode of acute cellular rejection one month prior to presentation, successfully treated with steroids. His immunosuppression consisted of tacrolimus and mycophenolic acid. Read More

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http://doi.wiley.com/10.1002/lt.25416
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http://dx.doi.org/10.1002/lt.25416DOI Listing
January 2019
5 Reads

Oxaloacetate protects rat liver from experimental warm ischemia-reperfusion injury by improving cellular energy metabolism.

Liver Transpl 2019 Jan 21. Epub 2019 Jan 21.

Laboratoire d'hépatologie cellulaire, Centre de recherche du Centre hospitalier de l', Université de Montréal (CRCHUM), Montréal, QC, Canada.

Liver ischemia/reperfusion injury is an important cause of liver damage especially early after liver transplantation, following liver resection and in other clinical situations. Using rat experimental models, we identified oxaloacetate (OAA) as a key metabolite able to protect hepatocytes from hypoxia and ischemia/reperfusion injury. In vitro screening of metabolic intermediates beneficial for hepatocyte survival under hypoxia was performed by measures of cell death and injury. Read More

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http://dx.doi.org/10.1002/lt.25415DOI Listing
January 2019
1 Read

Too Much or Not Enough? Induction Immunosuppression in the Simultaneous Liver-Kidney Recipient.

Liver Transpl 2019 Jan 19. Epub 2019 Jan 19.

Division of Gastroenterology and Hepatology and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

In this issue, AbdulRahim et al. attempt the role of induction therapy by a retrospective analysis of 7927 patients who had undergone simultaneous liver-kidney transplant (SLK) to evaluate the clinical utility and impact of induction therapy on 1-year acute rejection rates and mortality. The analysis revealed a higher mortality in patients treated with antithymocyte globulin (r-ATG) than with interleukin-2 receptor antibody (IL2RA) or no induction with no difference in acute rejection rates for either graft across groups. Read More

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http://dx.doi.org/10.1002/lt.25414DOI Listing
January 2019

Decreased fibrinolytic capacity in cirrhosis and liver transplant outcomes.

Authors:
Ton Lisman

Liver Transpl 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Patients with advanced liver disease develop multiple changes in hemostasis. The net result of these changes appears to be a hemostatic system that is in balance but has distinct hyper- and hypocoagulable features . Studies over the last 15 years have characterized these changes in hemostasis and their consequences, leading to profound changes in the management of patients with liver disease. Read More

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http://dx.doi.org/10.1002/lt.25412DOI Listing
January 2019

Predicting outcomes of liver transplantation in patients with NASH: pre-transplant renal function is key.

Liver Transpl 2019 Jan 18. Epub 2019 Jan 18.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy.

Patients with renal impairment prior to LT have an increased risk of end-stage renal disease and post-LT mortality[1]. Since the introduction of the Model for End-Stage Liver Disease, the number of recipients with renal impairment prior to LT has significantly increased. This was paralleled by a concomitant increase of simultaneous liver-kidney transplantation (SLKT)[2] and severe chronic kidney disease (CKD) after LT[3]. Read More

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http://dx.doi.org/10.1002/lt.25413DOI Listing
January 2019
1 Read

Elevated risk of split liver grafts in adult liver transplantation; statistical artifact or nature of the beast?

Liver Transpl 2019 Jan 7. Epub 2019 Jan 7.

Cleveland Clinic Lerner College of Medicine, and Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, 44195.

Background: A recent study using US national registry data has reported that split liver transplant (SLT) has improved over-time and no more hazardous than whole liver transplant using Cox proportional hazard (PH) models. However, the study methods violated PH assumption, the fundamental assumption of Cox modeling. As a result, the reported HR are biased and unreliable. Read More

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http://doi.wiley.com/10.1002/lt.25409
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http://dx.doi.org/10.1002/lt.25409DOI Listing
January 2019
4 Reads

Not All Cellular Rejections are the Same: Differences in Early and Late Hepatic Allograft Rejection.

Liver Transpl 2019 Jan 7. Epub 2019 Jan 7.

William von J Liebig Center for Transplantation, Mayo Clinic, Rochester, MN.

T-cell mediated rejection (TCMR) is common after liver transplantation (LT), and is often thought to have minimum impact on outcomes. Because alloimmune response changes over time, we investigated the role of the timing of TCMR on patient and allograft survival, and examined the risk factors for early and late TCMR. 787 consecutive LT recipients with protocol liver biopsies were reviewed, with an 8. Read More

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http://dx.doi.org/10.1002/lt.25411DOI Listing
January 2019

Reply: Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver Kidney Transplants.

Liver Transpl 2019 Jan 7. Epub 2019 Jan 7.

UT Southwestern Medical Center, Dallas, TX.

We thank Ekser et al. for sharing their experience with thymoglobulin as induction therapy in their population of simultaneous liver kidney transplant (SLKT) patients. The purpose of their study was to ascertain if differences in KDPI or delayed kidney transplant (KT) leads to improvement in patient survival. Read More

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http://dx.doi.org/10.1002/lt.25407DOI Listing
January 2019

Predictors of De Novo Nonalcoholic Fatty Liver Disease After Liver Transplantation and Associated Fibrosis.

Liver Transpl 2019 Jan;25(1):56-67

Multi-Organ Transplant Program.

Nonalcoholic fatty liver disease (NAFLD) can occur de novo in patients undergoing liver transplantation (LT) for indications other than NAFLD, and it has been increasingly recognized as a complication in the post-LT setting. This study aims to better characterize de novo NAFLD after LT by identifying risk factors for its development, describing incidence and extent of fibrosis, assessing the diagnostic utility of noninvasive serum fibrosis algorithms, and comparing survival to those without NAFLD. This was a retrospective single-center analysis of de novo NAFLD in a post-LT cohort. Read More

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http://doi.wiley.com/10.1002/lt.25338
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http://dx.doi.org/10.1002/lt.25338DOI Listing
January 2019
4 Reads

2018 Liver Transplantation Referees.

Authors:

Liver Transpl 2019 Jan;25(1):186-187

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http://dx.doi.org/10.1002/lt.25397DOI Listing
January 2019

Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand.

Liver Transpl 2019 Jan;25(1):25-34

Medical School, University of Western Australia, Nedlands, Australia.

The worldwide increase in obesity and diabetes has led to predictions that nonalcoholic steatohepatitis (NASH) will become the leading indication for orthotopic liver transplantation (OLT). Data supporting this prediction from outside the United States are limited. Thus, we aimed to determine trends in the frequency of NASH among adults listed and undergoing OLT in Australia and New Zealand (ANZ) from 1994 to 2017. Read More

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http://doi.wiley.com/10.1002/lt.25361
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http://dx.doi.org/10.1002/lt.25361DOI Listing
January 2019
5 Reads

Very Early Introduction of Everolimus in De Novo Liver Transplantation: Results of a Multicenter, Prospective, Randomized Trial.

Liver Transpl 2019 Feb;25(2):242-251

Dipartimento di Chirurgia Generale e Trapianti d'Organo, Policlinico, Universitario Agostino Gemelli, Rome, Italy.

Early everolimus (EVR) introduction and tacrolimus (TAC) minimization after liver transplantation may represent a novel immunosuppressant approach. This phase 2, multicenter, randomized, open-label trial evaluated the safety and efficacy of early EVR initiation. Patients treated with corticosteroids, TAC, and basiliximab were randomized (2:1) to receive EVR (1. Read More

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http://dx.doi.org/10.1002/lt.25400DOI Listing
February 2019
7 Reads

Long-Term Impact of Live Liver Donation: A Self Report of the Donation Experience.

Liver Transpl 2018 Dec 27. Epub 2018 Dec 27.

NYU Langone Medical Center, New York, NY, United States.

Outcomes for adult-to-adult living liver donors are largely based on short-term data drawn from single center studies. The aim of this study was to determine how living liver donation impacts self-reported Quality-of-Life up to 6 years post-donation in a sample of NYS residents.

Methods: NYS transplant programs are state-mandated to track living liver donors as part of a quality assurance and patient safety effort. Read More

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http://doi.wiley.com/10.1002/lt.25402
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http://dx.doi.org/10.1002/lt.25402DOI Listing
December 2018
8 Reads

Noninvasive Assessment of Hepatocellular Carcinoma Tumor Thrombus: Is It All in Vein?

Liver Transpl 2019 Feb;25(2):201-202

Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA.

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http://dx.doi.org/10.1002/lt.25403DOI Listing
February 2019

Outcomes of Sleeve Gastrectomy in Obese Liver Transplant Candidates.

Liver Transpl 2018 Dec 27. Epub 2018 Dec 27.

Department of Surgery, University of California San Francisco, San Francisco, CA.

Morbid obesity (body mass index ≥40kg/m ) is a relative contraindication to liver transplantation (LT) at many transplant centers. The safety and efficacy of pre-LT bariatric surgery in morbidly obese LT candidates is unknown. Herein, we describe a cohort study of morbidly obese LT candidates who failed to achieve adequate weight loss through a medically-supervised weight loss program and subsequently underwent sleeve gastrectomy (SG) at our institution. Read More

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http://dx.doi.org/10.1002/lt.25406DOI Listing
December 2018

Feasibility and Safety of Split Liver Transplantation in the Indian Context.

Liver Transpl 2018 Dec 26. Epub 2018 Dec 26.

Dr. Rela Institute and Medical Centre, Chennai, India.

Introduction: Split liver transplantation (SLT) is a valuable option for optimizing the use of good quality deceased donor grafts. It is not routinely reported outside the West due to limited deceased donor numbers, technical and organizational constraints, lack of experience, and predominant living donor liver transplant (LDLT) practice. Twenty percent of the liver transplants at our centre are from deceased donors. Read More

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http://dx.doi.org/10.1002/lt.25405DOI Listing
December 2018
1 Read

Backing Into Benefit: What Fringe Donors Can Teach the Mainstream.

Authors:
Raymond J Lynch

Liver Transpl 2019 Feb;25(2):205-206

Department of Surgery, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1002/lt.25404DOI Listing
February 2019

Prior Bariatric Surgery in Liver Transplant Candidates: Unforeseen Consequences?

Liver Transpl 2019 Feb;25(2):203-204

Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA.

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http://doi.wiley.com/10.1002/lt.25401
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http://dx.doi.org/10.1002/lt.25401DOI Listing
February 2019
3 Reads

Frequency and Outcomes of Abnormal Imaging in Patients with Cirrhosis Enrolled in a Hepatocellular Carcinoma Surveillance Program.

Liver Transpl 2018 Dec 24. Epub 2018 Dec 24.

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.

Background: There are limited data on downstream effects of hepatocellular carcinoma (HCC) surveillance, including frequency of false positive results. We aimed to quantify the incidence of indeterminate nodules and follow-up testing needed to resolve these findings among patients enrolled in a structured HCC surveillance program.

Methods: We retrospectively analyzed adult cirrhosis patients enrolled in a structured HCC surveillance program in a large tertiary care center. Read More

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http://dx.doi.org/10.1002/lt.25398DOI Listing
December 2018
1 Read

Bariatric surgery and long-term outcomes.

Liver Transpl 2018 Dec 24. Epub 2018 Dec 24.

Baylor University Medical Center, Dallas, Texas.

We appreciate the interest in our work by Professor Yildiz looking at the association between bariatric surgery and outcomes among patients evaluated for liver transplantation.(1) We share the sentiment that some of the outcomes noted in the study may be related to malabsorptive rather than restrictive weight reduction surgery. As reflected in the results, rates of delisting or death were high for gastric bypass versus non-gastric bypass patients (44% vs. Read More

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http://dx.doi.org/10.1002/lt.25399DOI Listing
December 2018

Gene Silencing With siRNA (RNA Interference): A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation

Liver Transpl 2019 01;25(1):140-151

Department of Surgery, Division of Organ Transplantation, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA.

RNA interference (RNAi) is a natural process of posttranscriptional gene regulation that has raised a lot of attention culminating with the Nobel Prize in Medicine in 2006. RNAi-based therapeutics have been tested in experimental transplantation to reduce ischemia/reperfusion injury (IRI) with success. Modulation of genes of the innate immune system, as well as apoptotic genes, and those involved in the nuclear factor kappa B pathways can reduce liver injury in rodent liver pedicle clamping and transplantation models of IRI. Read More

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http://dx.doi.org/10.1002/lt.25383DOI Listing
January 2019
2 Reads

Put The Blame On Gastric Bypass.

Authors:
Baris D Yildiz

Liver Transpl 2018 Dec 14. Epub 2018 Dec 14.

Ankara Numune Teaching Hospital General Surgery, Sihhiye, Ankara, Turkey.

We read with great interest the article titled "Impact of prior bariatric surgery on perioperative liver transplant outcomes" by Idriss et al (1). The authors gave a unique perspective to bariatric surgery and its relation to liver transplantation (LT). Although Roux and Y gastric bypass (RYGB) used to be considered as the gold standard (2) bariatric surgery procedure; since 2014 more than 50% of all bariatric procedures are sleeve gastrectomies (SG) (3). Read More

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http://dx.doi.org/10.1002/lt.25396DOI Listing
December 2018

Fibrinolytic Shutdown Is Associated With Thrombotic and Hemorrhagic Complications and Poorer Outcomes After Liver Transplantation.

Liver Transpl 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesia, University of Miami/Jackson Memorial Hospital, Miami, FL.

Detrimental consequences of hypofibrinolysis, also known as fibrinolytic shutdown (FS), have recently arisen, and its significance in liver transplantation remains unknown. To fill this gap, this retrospective study included 166 adults who received transplants between 2016 and 2018 for whom baseline thromboelastography was available. Based on percent (%) clot lysis 30 minutes after maximal amplitude, patients were stratified into 3 fibrinolysis phenotypes: FS, physiologic fibrinolysis, and hyperfibrinolysis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25394
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http://dx.doi.org/10.1002/lt.25394DOI Listing
December 2018
9 Reads

Heterozygosity for the Alpha-1-Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease.

Liver Transpl 2019 Feb;25(2):342-343

Internal Medicine III, University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.1002/lt.25393DOI Listing
February 2019
2 Reads

Living donor Liver transplantation for Acute on chronic Liver failure.

Liver Transpl 2018 Dec 8. Epub 2018 Dec 8.

Institute of Liver Transplantation and Regenerative Medicine, Medanta-The Medicity Gurugram-122001, Delhi (NCR), India.

Introduction: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of previously diagnosed or undiagnosed liver disease with organ failure(s) with high short-term mortality. This study was conducted to report the outcomes of LDLT in ACLF and assess the survival benefit of liver transplantation in these patients.

Materials And Methods: It was a retrospective study of 218 ACLF patients (based on EASL-CLIF criteria) from January 2014 through November 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25395
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http://dx.doi.org/10.1002/lt.25395DOI Listing
December 2018
10 Reads

Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver Kidney Transplants.

Liver Transpl 2018 Dec 2. Epub 2018 Dec 2.

Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX.

The number of simultaneous liver kidney transplant (SLKT) and the concomitant use of induction therapy have increased over the last decade. However, there is little data comparing outcomes amongst induction agents in the context of maintenance immunosuppression regimen consisting of tacrolimus and mycophenolic acid (TAC/MPA). We queried the OPTN registry for SLKT recipients maintained on TAC/MPA at discharge in the U. Read More

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http://dx.doi.org/10.1002/lt.25390DOI Listing
December 2018
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Surgical training and simulation of split liver transplantation in an ex vivo porcine model.

Liver Transpl 2018 Dec 1. Epub 2018 Dec 1.

Department of Transplant Surgery, Jichi Medical University.

The use of technical variant donation, including split liver transplantation (SLT) and living donor liver transplantation, represents a potential solution to the organ shortage. The SLT allows transplantation of two recipients from one deceased donor, thereby increasing the pool of grafts.Although SLT might have provided an opportunity to increase organ supply without compromising post-transplant outcomes, SLT may still be conflicting and limited by an uncertain long-term outcome of split liver grafts. Read More

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http://dx.doi.org/10.1002/lt.25391DOI Listing
December 2018

Auxiliary Partial Orthotopic Liver Transplantation for Noncirrhotic Metabolic Liver Disease: Reigniting Interest in an Old but New Technique.

Liver Transpl 2019 Jan;25(1):12-13

Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1002/lt.25388DOI Listing
January 2019
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Sarcopenia and Frailty in the Prognosis of Patients on the Liver Transplant Waiting List.

Liver Transpl 2019 Jan;25(1):7-9

Division of Gastroenterology and Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1002/lt.25386DOI Listing
January 2019

Nonalcoholic Steatohepatitis Is Becoming a Top Indication for Liver Transplantation Worldwide.

Liver Transpl 2019 Jan;25(1):10-11

Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA.

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http://dx.doi.org/10.1002/lt.25387DOI Listing
January 2019
7 Reads

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Liver Transpl 2019 Jan;25(1):178-179

HPB Surgery and Transplants Department, Hospital Universiatri Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1002/lt.25389DOI Listing
January 2019
6 Reads