108,722 results match your criteria Liver Transplantation


QT and Outcomes in Cirrhosis: A prolonged debate on causality in need of correction.

Am J Transplant 2020 Jul 13. Epub 2020 Jul 13.

Department of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.

As the field of transplant has advanced, cardiovascular events have become the leading cause of early death after liver transplantation (LT) ahead of graft failure and infection. This trend has been bolstered by the transplantation of older and sicker patients who have an increasing amount of cardiometabolic risk factors, accentuating the need to determine which patients should undergo more extensive cardiac evaluation. The electrocardiogram (ECG) has been used for decades for perioperative risk stratification, and in particular the QT interval corrected for heart rate (QTc) has been of interest. Read More

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http://dx.doi.org/10.1111/ajt.16209DOI Listing

Novel therapeutics for portal hypertension and fibrosis in chronic liver disease.

Pharmacol Ther 2020 Jul 10:107626. Epub 2020 Jul 10.

Hepatology, Department of Biomedical Research, Inselspital & University of Bern, Switzerland.; Liver Vascular Biology Research Group, Barcelona Hepatic Hemodynamic Unit, IDIBAPS, CIBEREHD, Barcelona, Spain. Electronic address:

Portal hypertension (PH) is the most common non-neoplastic complication of chronic liver disease, determining clinical complications that lead to death or liver transplantation. PH results from increased resistance to portal blood flow through the cirrhotic liver, which is due to hepatic fibrosis and microcirculatory dysfunction. The present review focuses on the pathophysiology of fibrosis and PH, describes currently used treatments, and critically discusses potential therapeutic options. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107626DOI Listing

Fully automated quantitative assessment of hepatic steatosis in liver transplants.

Comput Biol Med 2020 May 29;123:103836. Epub 2020 May 29.

Politobiomed Lab, Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Turin, Italy.

Background: The presence of macro- and microvesicular steatosis is one of the major risk factors for liver transplantation. An accurate assessment of the steatosis percentage is crucial for determining liver graft transplantability, which is currently based on the pathologists' visual evaluations on liver histology specimens.

Method: The aim of this study was to develop and validate a fully automated algorithm, called HEPASS (HEPatic Adaptive Steatosis Segmentation), for both micro- and macro-steatosis detection in digital liver histological images. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2020.103836DOI Listing

Gastrointestinal Organoids: A Next Generation Tool for Modeling Human Development.

Am J Physiol Gastrointest Liver Physiol 2020 Jul 13. Epub 2020 Jul 13.

Colorectal Center for Children, Cincinnati Children's Hospital, United States.

Gastrointestinal organoids are an exciting new tool for modeling human development, physiology, and disease in human tissue. Derived from pluripotent stem cells (PSCs), gastrointestinal organoids consist of epithelial and mesenchymal cells organized in an intricate, three-dimensional structure that recapitulates the physiology and microscopic anatomy of the human GI tract. In vitro derivation of gastrointestinal organoids from Definitive Endoderm has permitted an exploration of the complex signaling pathways required for the initial maturation of each individual gastrointestinal organ. Read More

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http://dx.doi.org/10.1152/ajpgi.00199.2020DOI Listing

Does the Surgeon's Caseload Affect the Outcome in Laparoscopic Cholecystectomy for Acute Cholecystitis?

Surg Laparosc Endosc Percutan Tech 2020 Jul 10. Epub 2020 Jul 10.

Departments of Abdominal Surgery.

Background: This study investigated how annual caseloads and the surgeon's previous experience influence the outcome in laparoscopic cholecystectomy (LCC) for acute cholecystitis.

Methods: A total of 892 patients treated in Helsinki University Hospital in 2013-2016 were retrospectively analyzed. Surgeons were compared regarding volume-over 5 LCCs for acute cholecystitis a year versus 5 or fewer LCCs a year, and experience-attendings versus residents. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000828DOI Listing

Transferability of Liver Transplantation Experience to Complex Liver Resection for Locally Advanced Hepatobiliary Malignancy - Lessons Learnt From 3 Decades of Single Center Experience.

Ann Surg 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.

Objective: To study the impact of LT experience on the outcome of CLR for locally advanced hepatobiliary malignancy SUMMARY OF BACKGROUND DATA:: Despite evolution in LT knowledge and surgical techniques in the past decades, there is yet data to evaluate the significance of LT experience in performing CLR.

Methods: Postoperative outcome after CLR between 1995 and 2019 were reviewed and correlated with LT experience in a single center with both LT and CLR service. CLR was defined as hepatectomy with vasculobiliary reconstruction, or multivisceral resection, central bisectionectomy (S4/5/8), or associating liver partition and portal vein ligation for staged hepatectomy. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004227DOI Listing

Risk Factors of Positive Resection Margin in Laparoscopic and Open Liver Surgery for Colorectal Liver Metastases: A New Perspective in the Perioperative Assessment: A European Multicenter Study.

Ann Surg 2020 Jul 9. Epub 2020 Jul 9.

Department of Hepatobiliary and Pancreatic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

Objective: To assess the risk factors associated with R1 resection in patients undergoing OLS and LLS for CRLMs.

Background: The clinical impact of R1 resection in liver surgery for CRLMs has been continuously appraised, but R1 risk factors have not been clearly defined yet.

Methods: A cohort study of patients who underwent OLS and LLS for CRLMs in 9 European high-volume referral centers was performed. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004077DOI Listing

Colorectal Cancer Surgery during COVID-19 Pandemic in Iran; Most Appropriate Approach.

Arch Iran Med 2020 Jul 1;23(7):505-506. Epub 2020 Jul 1.

Department of Surgery, Shohada-e-Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.34172/aim.2020.49DOI Listing

Opioid avoidance in liver transplant recipients: reduction in postoperative opioid use through a multidisciplinary, multimodal approach.

Liver Transpl 2020 Jul 13. Epub 2020 Jul 13.

Department of Transplant, Hartford Hospital, Hartford, Connecticut, United States.

Background: The prevalence of substance use disorder in the liver transplant (LT) population makes post-operative pain management challenging.

Methods: We report our initial experience with a novel comprehensive, multidisciplinary opioid avoidance pathway in 13 LT recipients between January 2018 and September 2019. Patients received comprehensive pre-LT education on post-operative opioid avoidance by the surgeon, pharmacist, and psychologist at the time of listing. Read More

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http://dx.doi.org/10.1002/lt.25847DOI Listing

Roadmap to Resuming Care for Liver Diseases after COVID-19.

J Gastroenterol Hepatol 2020 Jul 13. Epub 2020 Jul 13.

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

The global pandemic of coronavirus disease-2019 (COVID-19) has led to significant disruptions in care delivery. Patients with chronic liver diseases require a high level of care and are therefore particularly vulnerable to disruptions in medical services during COVID-19. Recent data has also identified chronic liver disease as an independent risk factor for COVID-19 related hospital mortality. Read More

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http://dx.doi.org/10.1111/jgh.15178DOI Listing

Aortic valve-sparing procedure-a durable choice in liver transplantation recipient.

Gen Thorac Cardiovasc Surg 2020 Jul 12. Epub 2020 Jul 12.

Sezione Autonoma Di Cardiochirurgia Universitaria, Section of Cardiac Surgery, Pisa University Hospital, Via Paradisa, 2, 56124, Pisa, Italy.

A 44-year old man with aortic regurgitation and aneurysm of the ascending aorta underwent an aortic valve-sparing procedure as a durable treatment before liver transplantation. Since patients with chronic liver failure are at high risk of hemorrhagic complications at time of major surgery, while management of warfarin administration may still represent a concern, the choice of a cardiac procedure which avoids any anticoagulant treatment appeared justified. Read More

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http://dx.doi.org/10.1007/s11748-020-01434-yDOI Listing

Implementing a Process to Systematically Identify and Address Poor Medication Adherence in Pediatric Liver Transplant Recipients.

Pediatr Qual Saf 2020 May-Jun;5(3):e296. Epub 2020 May 13.

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objectives: Poor adherence to medication following pediatric liver transplantation remains a major challenge, with some estimates suggesting that 50% of adolescent liver transplant recipients exhibit reduced medication adherence. To date, no gold standard has emerged to address this challenge; however, system interventions are most likely to be successful. We sought to implement a system to identify and address adherence barriers in a liver transplant clinic. Read More

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http://dx.doi.org/10.1097/pq9.0000000000000296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297389PMC

Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.

NPJ Precis Oncol 2020 7;4:20. Epub 2020 Jul 7.

Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, DNA methylome, and transcriptome analyses, of 59 hepatoblastoma samples. Based on DNA methylation patterns, hepatoblastoma was classified into three clusters exhibiting remarkable correlation with clinical, histological, and genetic features. Read More

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http://dx.doi.org/10.1038/s41698-020-0125-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341754PMC

Long Noncoding RNA LINC01134 Promotes Hepatocellular Carcinoma Metastasis via Activating AKT1S1 and NF-κB Signaling.

Front Cell Dev Biol 2020 12;8:429. Epub 2020 Jun 12.

Hepatic Surgery Center, Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancies with poor outcomes. The main causes of HCC-related deaths are recurrence and metastasis. Long noncoding RNAs (lncRNAs) are recently identified as critical regulators in cancers. Read More

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http://dx.doi.org/10.3389/fcell.2020.00429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325970PMC

Liver transplantation in the treatment of unresectable hepatic metastasis from neuroendocrine tumors.

J Gastrointest Oncol 2020 Jun;11(3):601-608

Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Neuroendocrine tumors (NET) are rare neoplasms with generally indolent growth behavior. The liver is the most common site of NET metastasis. The NET metastatic spread to the liver are usually multiple tumors involving bilateral hemilivers. Read More

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http://dx.doi.org/10.21037/jgo.2019.11.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340808PMC

Surgical management of primary pancreatic neuroendocrine tumors.

J Gastrointest Oncol 2020 Jun;11(3):578-589

Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Pancreatic neuroendocrine tumors (PanNETs) are the second most common malignancy of the pancreas, and their incidence is increasing. PanNETs are a diverse group of diseases which range from benign to malignant, can be sporadic or associated with genetic mutations, and be functional or nonfunctional. In as much, the treatment and management of PanNETs can vary from a "Wait and See" approach to orthotopic liver transplantation (OLT). Read More

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http://dx.doi.org/10.21037/jgo.2019.12.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340810PMC

Prognostic value of combined preoperative gamma-glutamyl transpeptidase to platelet ratio and fibrinogen in patients with HBV-related hepatocellular carcinoma after hepatectomy.

Am J Transl Res 2020 15;12(6):2984-2997. Epub 2020 Jun 15.

Department of Hepatic Surgery and Liver Transplant Program, The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630, China.

The gamma-glutamyl transpeptidase to platelet ratio (GPR) has been reported as a non-invasive parameter for evaluating hepatic fibrosis and cirrhosis. However, only a few of studies investigated the relationship between GPR and liver cancer. Here, we sought to clarify the prognostic value of GPR as well as its combination with fibrinogen in patients with HBV-related hepatocellular carcinoma (HCC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344083PMC

Co-administration of everolimus and N-acetylcysteine attenuates hepatic stellate cell activation and hepatic fibrosis.

Am J Transl Res 2020 15;12(6):2627-2639. Epub 2020 Jun 15.

Department of HBP Surgery & Liver Transplantation, Department of Surgery, Korea University College of Medicine Seoul 02841, Republic of Korea.

The accelerated course of hepatic fibrosis that occurs in some patients after liver transplantation is an important clinical problem. Activation of hepatic stellate cell (HSCs) is the dominant event in hepatic fibrosis. Previous studies have shown that treatment with mammalian target of rapamycin (mTOR) inhibitors was more effective in reducing the progression of fibrosis than treatment with calcineurin inhibitors, suggesting that mTOR could be a crucial target for inhibition of fibrosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344068PMC

Adoptive transfer of polarized M2c macrophages ameliorates acute rejection in rat liver transplantation.

Am J Transl Res 2020 15;12(6):2614-2626. Epub 2020 Jun 15.

Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University Xi'an, China.

Hepatic macrophages play pivotal roles in tolerance induction after liver transplantation (LT). However, macrophages possess functional heterogeneities, and the protective role of M2c macrophages, a macrophage subtype characterized by the surface marker CD163 that secretes interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1), in acute rejection following LT, has not been addressed. The aim of this study was to determine whether polarized macrophages of the M2c subtype could improve outcomes after LT for rats, including survival rate, liver function, and inflammatory infiltration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344085PMC

The Impact of COVID-19 Global Pandemic on Morbidity and Mortality of Liver Transplant Recipients Children and Adults: A Systematic Review of Case Series.

J Clin Med Res 2020 Jul 25;12(7):404-408. Epub 2020 Jun 25.

Division of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, W12 0HS, UK.

The pandemic of coronavirus disease 2019 (COVID-19) changed the surgical everyday practice overnight. Currently, the first articles reporting outcomes of liver transplant recipients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are published. The aim of the present study was to summarise the existing evidence of impact of COVID-19 global pandemic on liver transplant recipients. Read More

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http://dx.doi.org/10.14740/jocmr4223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331863PMC

The polyphenol-rich extract from chokeberry ( L) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats.

Nutr Metab (Lond) 2020 7;17:54. Epub 2020 Jul 7.

College of Biological Sciences and Technology, Beijing Forestry University, Beijing, 100083 China.

The gut microbiota plays a critical role in obesity and lipid metabolism disorder. Chokeberry ( L) are rich in polyphenols with various physiological and pharmacological activities. We determined serum physiological parameters and fecal microbial components by using related kits, liquid chromatography-mass spectrometry (LC-MS) and 16S rRNA gene sequencing every 10 days. Read More

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http://dx.doi.org/10.1186/s12986-020-00473-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339576PMC

The Human Immune Response to Cadaveric and Living Donor Liver Allografts.

Front Immunol 2020 22;11:1227. Epub 2020 Jun 22.

The Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

The liver is an important contributor to the human immune system and it plays a pivotal role in the creation of both immunoreactive and tolerogenic conditions. Liver transplantation provides the best chance of survival for both children and adults with liver failure or cancer. With current demand exceeding the number of transplantable livers from donors following brain death, improved knowledge, technical advances and the desire to prevent avoidable deaths has led to the transplantation of organs from living, ABO incompatible (ABOi), cardiac death donors and machine based organ preservation with acceptable results. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323572PMC

Ultrasound liver elastography beyond liver fibrosis assessment.

World J Gastroenterol 2020 Jun;26(24):3413-3420

Northeastern Ohio Medical University, Rootstown, OH 44272, United States.

Several guidelines have indicated that liver stiffness (LS) assessed by means of shear wave elastography (SWE) can safely replace liver biopsy in several clinical scenarios, particularly in patients with chronic viral hepatitis. However, an increase of LS may be due to some other clinical conditions not related to fibrosis, such as liver inflammation, acute hepatitis, obstructive cholestasis, liver congestion, infiltrative liver diseases. This review analyzes the role that SWE can play in cases of liver congestion due to right-sided heart failure, congenital heart diseases or valvular diseases. Read More

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http://dx.doi.org/10.3748/wjg.v26.i24.3413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327790PMC
June 2020
2.369 Impact Factor

Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):339-376. Epub 2020 Apr 28.

Institute of Liver & Digestive Diseases and Head of Hepatology & Liver Transplant (Medicine), BLK Super Speciality Hospital, Delhi, India.

Acute liver failure (ALF) is an infrequent, unpredictable, potentially fatal complication of acute liver injury (ALI) consequent to varied etiologies. Etiologies of ALF as reported in the literature have regional differences, which affects the clinical presentation and natural course. In this part of the consensus article designed to reflect the clinical practices in India, disease burden, epidemiology, clinical presentation, monitoring, and prognostication have been discussed. Read More

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http://dx.doi.org/10.1016/j.jceh.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335721PMC

Do Recipients of Genetically Related Donors Have Better Outcomes After Living Donor Liver Transplantation?

J Clin Exp Hepatol 2020 Jul-Aug;10(4):334-338. Epub 2019 Dec 27.

Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, India.

Background: There are few data on genetic relation of the donor and outcomes in living donor liver transplantation (LDLT) recipients. We compared outcomes of LDLT between recipients of genetically related and unrelated donors in a large single-center series.

Methods: The study included 1372 adult, ABO-compatible, primary LDLT recipients, who received a graft from either a first-degree relative (parent, sibling, son, or daughter; n = 756) or unrelated donor (spouse or relative of the spouse; n = 616). Read More

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http://dx.doi.org/10.1016/j.jceh.2019.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335709PMC
December 2019

Pregnancy After Liver Transplantation: Outcomes From a Single-Center Experience.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):329-333. Epub 2019 Oct 30.

Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, 682041, Kerala, India.

Background/objectives: Although much has been learnt regarding pregnancy after liver transplantation, data from India are scant. Hence, we evaluated the maternal and fetal outcomes of pregnancies after liver transplantation at our center.

Methods: We conducted a retrospective review of all patients who underwent liver transplantation and later conceived at our center between 2006 and 2019. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335724PMC
October 2019

Liver Transplant in Acute Liver Failure - Looking Back Over 10 Years.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):322-328. Epub 2019 Oct 31.

Department of GI Surgery and Solid Organ Transplantation, Amrita Institute of Medical Sciences & Research Centre, Ponekkara, Kochi, 682041, Kerala, India.

Background: Acute liver failure (ALF) is the leading cause for emergency liver transplantation (LT) all over the world. We looked at the profile of cases who required LT for ALF from a single centre to identify the possible predictors of poor outcomes.

Methodology: During the 10-year period starting from 2007, 320 cases of ALF were treated at our institution, of which 70 (median age 24 years, Male:Female 1:2) underwent LT. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335718PMC
October 2019

Incidence and Risk Factors for Hepatitis C Virus and Hepatitis B Virus Seroconversion in End-Stage Renal Failure Patients on Maintenance Hemodialysis.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):316-321. Epub 2019 Nov 27.

Post Graduate Institute of Medical Education and Research, Nephrology, India.

Background: Renal replacement therapy in the form of either dialysis or transplantation is the only option for end-stage renal disease (ESRD). Blood-borne infections such as hepatitis B virus (HBV) and hepatitis C virus (HCV) are of special concern in these patients because of their high incidence. Although there are sufficient data from the developed world, there is scarcity of data from developing countries such as India. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335726PMC
November 2019

Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):304-315. Epub 2019 Nov 22.

Department of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA.

Background: Liver transplantation (LT) is an accepted therapeutic option for hepatocellular carcinoma (HCC) in patients with cirrhosis. Despite careful candidate selection, HCC recurrence occurs. We aimed to describe the predictors of recurrence, clinical presentation, and predictors of survival after HCC recurrence post-LT. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335705PMC
November 2019

Diabetes and Hepatocellular Carcinoma: Incidence Trends and Impact of Liver Disease Etiology.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):296-303. Epub 2019 Nov 22.

Institute of Digestive Heath and Liver Diseases, Mercy Medical Center, Baltimore, MD, USA.

Background/aims: Hepatocellular carcinoma (HCC) remains the leading cause of cancer-related death among patients with type 2 diabetes mellitus (T2DM). We aimed to assess the independent role of T2DM on HCC risk among patients with different liver disease etiologies.

Methods: We analyzed the United Network for Organ Sharing database of all adults registered for liver transplantation (LT) between February 27, 2002 and December 31, 2017. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335702PMC
November 2019

Three-dimensional remnant pancreatic volume ratio indicates postoperative pancreatic exocrine insufficiency in pancreatic cancer patients after distal pancreatectomy.

Pancreatology 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Pancreatectomy may cause serious pancreatic exocrine insufficiency (PEI), which can lead to some nutritional problems, including new-onset diabetes mellitus (DM) or non-alcoholic fatty liver disease (NAFLD). Recent studies have reported that remnant pancreatic volume (RPV) significantly influences postoperative PEI. However, the specific correlation between RPV and postoperative PEI remains unclear. Read More

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http://dx.doi.org/10.1016/j.pan.2020.06.018DOI Listing

Non-alcoholic fatty liver disease: A review with clinical and pathological correlation.

J Formos Med Assoc 2020 Jul 9. Epub 2020 Jul 9.

Department of Pathology, University of Washington School of Medicine, Seattle, United States; Department of Medicine, University of Washington School of Medicine, Seattle, United States. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in North America and Europe, with increasing prevalence in other regions of the world. Its spectrum encompass steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. It is considered as the manifestation of metabolic syndrome in liver, and its development and progression is influenced by complex interaction of environmental and genetic factors. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.07.006DOI Listing

[Early efficacy of islet transplantation in the treatment of adult advanced diabetes].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(26):2040-2043

Organ Transplantation Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

To evaluate the safety and efficacy of islet transplantation for patients with advanced diabetes. Five cases of islet allotransplantation were performed on 4 adult recipients. The same blood type adult brain-dead pancreas donors were selected and the islets were prepared in GMP laboratory. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191012-02204DOI Listing

Simultaneous Liver-Kidney Transplantation from Donation after Cardiac Death Donors: An Updated Perspective.

Am J Transplant 2020 Jul 12. Epub 2020 Jul 12.

Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Phoenix, AZ, USA.

Outcomes of both donation after cardiac death (DCD) liver and kidney transplants are improving. Experience in simultaneous simultaneous liver-kidney (SLK) transplantation using DCD donors however remains limited. In an updated cohort (2010-2018), outcomes of 30 DCD SLK and 131 donation after brain death (DBD) SLK from Mayo Clinic Arizona and Minnesota were reviewed. Read More

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http://dx.doi.org/10.1111/ajt.16191DOI Listing

"Perioperative Presentation of COVID-19 Disease in a Liver Transplant Recipient".

Hepatology 2020 Jul 12. Epub 2020 Jul 12.

Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

In a recent issue of Hepatology, Drs. Qin and Wang report a case of a 37-year old patient with COVID-19 disease after undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). While these are interesting data on the course of COVID-19 disease in an immunosuppressed patient, we would like to highlight some particularly important issues related to management of liver disease and post-transplant care. Read More

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http://dx.doi.org/10.1002/hep.31458DOI Listing

A Step Towards Standardization: Results of Two National Surveys of Best Practices in Donation after Circulatory Death Liver Recovery and Recommendations from The American Society of Transplant Surgeons and Association of Organ Procurement Organizations.

Clin Transplant 2020 Jul 11:e14035. Epub 2020 Jul 11.

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, United States.

Donation after circulatory death (DCD) liver allografts remain underutilized. Inconsistent processes for DCD procurement may contribute to allograft discard. Optimal surgical and organ procurement organization (OPO) practices for DCD liver recovery should be developed and adopted. Read More

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http://dx.doi.org/10.1111/ctr.14035DOI Listing

National survey of physicians' perspectives on pharmacogenetic testing in solid organ transplantation.

Clin Transplant 2020 Jul 12:e14037. Epub 2020 Jul 12.

University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, United States.

Introduction: Our objective was to evaluate physicians' perspectives on the clinical utility of pharmacogenetic (PGx) testing in kidney, liver, heart, and lung transplantation (KLHL-Tx).

Methods: A 36-question web-based survey was developed and administered to medical and surgical directors of US KLHL-Tx centers.

Results: There were 82 respondents (10% response rate). Read More

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http://dx.doi.org/10.1111/ctr.14037DOI Listing

Usefulness of echocardiography to detect cardiac involvement in COVID-19 patients.

Echocardiography 2020 Jul 12. Epub 2020 Jul 12.

Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.

Coronavirus disease 2019 (COVID-19) outbreak is a current global healthcare burden, leading to the life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, evidence showed that, even if the prevalence of COVID-19 damage consists in pulmonary lesions and symptoms, it could also affect other organs, such as heart, liver, and spleen. Particularly, some infected patients refer to the emergency department for cardiovascular symptoms, and around 10% of COVID-19 victims had finally developed heart injury. Read More

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http://dx.doi.org/10.1111/echo.14779DOI Listing

Energy expenditure early after liver transplantation: better measured than predicted.

Nutrition 2020 Mar 20;79-80:110817. Epub 2020 Mar 20.

Department of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Objective: There is no consensus on how to estimate energy requirements after liver transplantation (LT). The aim of this study was to compare measured resting energy expenditure (REE) with predictive equations and fixed factors, and evaluate whether clinical variables were associated with REE.

Methods: During the period of 2011 through 2018, REE measured with indirect calorimetry and predicted by the Harris and Benedict (HB) equation was compared in patients during the first 30 postoperative days after LT. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110817DOI Listing

HCV treatment in cirrhotic patients: Should we use a different approach for patients with a liver transplant perspective?

J Hepatol 2020 Jul 8. Epub 2020 Jul 8.

Hepatobiliary Center, Paul Brousse Hospital APHP, Villejuif, France.

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http://dx.doi.org/10.1016/j.jhep.2020.05.026DOI Listing

How Much Is the Inevitable Loss of Different Coagulation Factors During Blood Product-Free Liver Transplantations?

Transplant Proc 2020 Jul 8. Epub 2020 Jul 8.

Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.

Background: Bloodless liver transplantations (LT) have already been reported, but special characteristics of hemostatic changes remain less defined. The aim of this study was to evaluate the "inevitable" loss of coagulation factors (CF) in blood product-free LT.

Methods: Blood product and CF concentrate-free LT patient data were analyzed in terms of the first 2 days of perioperative hemostasis kinetics (N = 59). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.006DOI Listing

[Summary of the recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) on the therapeutic drug monitoring of tacrolimus].

Therapie 2020 Jun 20. Epub 2020 Jun 20.

Service de pharmacologie, toxicologie et pharmacovigilance, CHU Limoges, 87000 Limoges, France; Inserm, UMR-1248, 87000 Limoges, France; Faculté de médicine, univeristé Limoges, 87000 Limoges, France.

Recently, the International Association of Therapeutic Drug Monitoring (IATDMCT), that is the learning society for biological pharmacology and toxicology, issued recommendations on the therapeutic drug monitoring (TDM) of tacrolimus. This is the second consensus after the one issued in 2009. In this document, the role of tacrolimus TDM for the four principal transplanted organs is discussed. Read More

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http://dx.doi.org/10.1016/j.therap.2020.06.004DOI Listing

Prevalence of COVID-19-like symptoms among people living with HIV, and using antiretroviral therapy for prevention and treatment.

Curr HIV Res 2020 Jul 12. Epub 2020 Jul 12.

Liver Transplantation Research Center, Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran. Iran.

Background: COVID-19 has spread globally with remarkable speed, and currently, there is limited data available exploring any aspect of the intersection between HIV and SARS-CoV-2 co-infection.

Objective: To estimate the prevalence of clinical symptoms associated with COVID-19 among people living with HIV (PLWH) in Tehran, Iran.

Design: Cross-sectional study. Read More

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http://dx.doi.org/10.2174/1570162X18666200712175535DOI Listing

Impact of extent of disease on 1-year healthcare costs in patients who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: retrospective observational cohort study.

BJS Open 2020 Jul 11. Epub 2020 Jul 11.

Departments of Surgery, Division of Surgical Oncology, Groningen, the Netherlands.

Background: The goal of this retrospective observational study was to determine the impact of the extent of peritoneal disease on 1-year healthcare costs in patients with colorectal peritoneal metastases (PM) who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). The extent of peritoneal disease, expressed by the Peritoneal Cancer Index (PCI), directly affects the complexity of CRS + HIPEC and ultimately survival outcomes. The impact of the PCI on treatment-related healthcare costs remains unknown. Read More

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http://dx.doi.org/10.1002/bjs5.50320DOI Listing

Bilioenteric Reconstruction Techniques in Pediatric Live Donor Liver Transplantation.

Liver Transpl 2020 Jul 11. Epub 2020 Jul 11.

Ege University, Faculty of Medicine, Department of Pediatric Gastroenterology, Izmir, Turkey.

Background: Biliary complications are still a major cause of morbidity following liver transplantation despite the advancements in the surgical technique. While Roux-en-Y hepaticojejunostomy has been the standard technique for years in pediatric cases, there are limited number of reports on the feasibility of duct-to-duct anastomosis with controversial outcomes. With the largest number of patients ever reported on the topic, this study aims to discuss the feasibility of duct-to-duct biliary reconstruction technique in pediatric live donor liver transplantation. Read More

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http://dx.doi.org/10.1002/lt.25845DOI Listing

Trends in liver transplantation for chronic hepatitis B in the era of highly potent antiviral therapies over the past two decades.

Liver Transpl 2020 Jul 11. Epub 2020 Jul 11.

The Liver Transplant Center, Queen Mary Hospital, Hong Kong SAR, Hong Kong.

Despite universal neonatal vaccination being implemented in 1988, the prevalence of chronic hepatitis B (CHB) infection remains high in Hong Kong. With antiviral therapy being available for over two decades now, there should be a significant decline in liver-related complications of CHB patients, especially with regards to cirrhosis and decompensated cirrhosis (1). Read More

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http://dx.doi.org/10.1002/lt.25846DOI Listing

Steroid-sparing maintenance immunosuppression is safe and effective after simultaneous liver kidney transplantation.

Clin Transplant 2020 Jul 11:e14036. Epub 2020 Jul 11.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Optimization of maintenance immunosuppression (mIS) regimens in the transplant recipient requires a balance between sufficient potency to prevent rejection and avoidance of excessive immunosuppression to prevent toxicities and complications. The optimal regimen after simultaneous liver-kidney (SLK) transplantation remains unclear, but small single-center reports have shown success with steroid-sparing regimens. We studied 4184 adult SLK recipients using the Scientific Registry of Transplant Recipients, from 3/1/2002-2/28/2017, on tacrolimus-based regimens at one year post-transplant. Read More

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http://dx.doi.org/10.1111/ctr.14036DOI Listing

Tissue-resident Mucosal-associated invariant T (MAIT) cells in the human kidney represent a functionally distinct subset.

Eur J Immunol 2020 Jul 11. Epub 2020 Jul 11.

Amsterdam UMC, University of Amsterdam, Division of Internal Medicine, Department of Nephrology, Renal Transplant Unit, Amsterdam Infection & Immunity Institute (AI&II), Meibergdreef 9, Amsterdam, The Netherlands.

Mucosal-associated invariant T (MAIT) cells are innate-like T-cells that recognize bacterial riboflavin metabolites. They are present in human blood but are abundant at barrier sites including the liver, lungs, and kidneys, where they possess a CD69 /CD103 tissue-resident phenotype. In renal tissue, MAIT cells likely defend against the ascending uropathogens responsible for urinary tract infections (UTIs), which are common, especially among renal transplant recipients (RTRs). Read More

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http://dx.doi.org/10.1002/eji.202048644DOI Listing

Liver resection in Cirrhotic liver: Are there any limits?

Int J Surg 2020 Jul 8. Epub 2020 Jul 8.

Chairman of HPB Surgical Division. Miguel Servet University Hospital. Zaragoza, Spain.

Liver resection remains one of the most technically challenging surgical procedure in abdominal surgery due to the complex anatomical arrangement in the liver and its rich blood supply that constitutes about 20% of the cardiac output per cycle. The challenge for resection in cirrhotic livers is even higher because of the impact of surgical stress and trauma imposed on borderline liver function and the impaired ability for liver regeneration in cirrhotic livers. Nonetheless, evolution and advancement in surgical techniques as well as knowledge in perioperative management of liver resection has led to a substantial improvement in surgical outcome in recent decade. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.050DOI Listing