100,579 results match your criteria Liver Transplantation


Intrahepatic Delivery of Pegylated Catalase Is Protective in a Rat Ischemia/Reperfusion Injury Model.

J Surg Res 2019 Feb 13;238:152-163. Epub 2019 Feb 13.

The COPPER Laboratory, The Ohio State University Wexner Medical Center, Columbus, Ohio; Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Ischemia/reperfusion injury (IRI) can occur during liver surgery. Endogenous catalase is important to cellular antioxidant defenses and is critical to IRI prevention. Pegylation of catalase (PEG-CAT) improves its therapeutic potential by extending plasma half-life, but systemic administration of exogenous PEG-CAT has been only mildly therapeutic for hepatic IRI. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.028DOI Listing
February 2019

A rare case of transient left ventricular apical ballooning syndrome following living donor liver transplantation: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:218-222. Epub 2019 Feb 10.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Introduction: Transient Left Ventricular Apical Balloon Syndrome (LV-ABS) is an unknown acute dysfunction of the left ventricle, which develops under emotional or physical stress events like the major surgical postoperative period.

Presentation Of Case: A 68-year-old woman diagnosed with hepatitis C cirrhosis was admitted for living donor liver transplantation (LDLT). No evidence for underlying cardiac or pulmonary disease was found. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193006
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http://dx.doi.org/10.1016/j.ijscr.2019.02.002DOI Listing
February 2019

Development of pre-engraftment syndrome, but not acute graft-versus-host disease, reduces relapse rate of acute myeloid leukemia after single cord blood transplantation.

Biol Blood Marrow Transplant 2019 Feb 13. Epub 2019 Feb 13.

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

The different effects of pre-engraftment syndrome (PES) and acute graft-versus-host disease (GVHD) on transplant outcomes after cord blood transplantation (CBT) are unclear. We retrospectively evaluated the impact of PES and acute GVHD on relapse and survival after single CBT for 138 adult patients with hematological malignancies in our institute between 2004 and 2016. Multivariate analysis demonstrated that development of grade III to IV acute GVHD, particularly gut or liver involvement of acute GVHD, significantly contributed to higher non-relapse mortality (P<0. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.007DOI Listing
February 2019

VEGF-C attenuates ischemia reperfusion injury of liver graft in rats.

Transpl Immunol 2019 Feb 13. Epub 2019 Feb 13.

Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Vascular endothelial growth factor receptor-3 (VEGFR-3) / vascular endothelial growth factor -c (VEGF-C) signaling is reported to negatively regulate TLR4-triggered inflammation of macrophages. This study aims to clarify whether the VEGFR-3/VEGF-C signaling can suppress Kupffer cells (KCs) activation and attenuate hepatic ischemia-reperfusion injury (IRI) after liver transplantation.

Methods: A rat model of liver transplantation was performed. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.004DOI Listing
February 2019

The learning curve in pure laparoscopic donor right hepatectomy: a cumulative sum analysis.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Seoul National University College of Medicine, 101 Daehakro, Jongrogu, Seoul, 03080, Republic of Korea.

Background: Although the use of pure laparoscopic donor hepatectomy (PLDH) is increasingly common, it remains limited to a few experienced centers and no data on the learning curve are currently available. The aim of this study is to evaluate the learning curve associated with the use of pure laparoscopic donor right hepatectomy (PLDRH).

Methods: Data from donors undergoing PLDRH performed by a single surgeon between November 2015 and October 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00464-019-06668-3DOI Listing
February 2019

Application of three-dimensional printing in pediatric living donor liver transplantation: a single-center experience.

Liver Transpl 2019 Feb 15. Epub 2019 Feb 15.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.

Background & Aims: Three-dimensional (3D) printing has been used to support organ translations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D printed liver models in pediatric living donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1002/lt.25435DOI Listing
February 2019

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.

Immunity 2019 Feb 5. Epub 2019 Feb 5.

Department of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Elevated glucose metabolism in immune cells represents a hallmark feature of many inflammatory diseases, such as sepsis. However, the role of individual glucose metabolic pathways during immune cell activation and inflammation remains incompletely understood. Here, we demonstrate a previously unrecognized anti-inflammatory function of the O-linked β-N-acetylglucosamine (O-GlcNAc) signaling associated with the hexosamine biosynthesis pathway (HBP). Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.007DOI Listing
February 2019

Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection.

Dig Liver Dis 2019 Jan 26. Epub 2019 Jan 26.

Department I of Internal Medicine, University Hospital of Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Germany. Electronic address:

Background & Aims: Faecal microbiota transplantation (FMT) has proven high clinical efficacy in the management of recurrent Clostridioides difficile infection (rCDI) with cure rates of over 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain elusive. The aim of the present study was to investigate different potential predictors of response to FMT. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.012DOI Listing
January 2019

Corticosteroid Therapy for Indeterminate Pediatric Acute Liver Failure and Aplastic Anemia with Acute Hepatitis.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objective: To examine the characteristics and outcomes of a multicenter patient cohort with indeterminate pediatric acute liver failure (IND-PALF) and with aplastic anemia with acute hepatitis treated with corticosteroids.

Study Design: Retrospective study of patients age 1-17 years with IND-PALF and aplastic anemia with acute hepatitis who presented between 2009 and 2018 to 1 of 4 institutions and were treated with corticosteroids for presumed immune dysregulation.

Results: Of 28 patients with IND-PALF (median of 4. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.042DOI Listing
February 2019

Endocrine pancreatic tumors: diagnosis and treatment.

Expert Rev Endocrinol Metab 2008 Mar;3(2):187-205

b Department of Medical Sciences, Section of Endocrine Oncology, University Hospital, 751 85 Uppsala, Sweden.

Endocrine pancreatic tumors (EPTs) are uncommon, having an incidence of one per 100,000 people. They may appear as sporadic tumors or be associated with hereditary syndromes. EPTs are categorized as functioning or nonfunctioning tumors, based on the presence or absence of clinical syndromes. Read More

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http://dx.doi.org/10.1586/17446651.3.2.187DOI Listing

Crigler-Najjar syndrome: therapeutic options and consequences of mutations in the UGT1A1 complex.

Expert Rev Endocrinol Metab 2008 Nov;3(6):725-737

b Paediatric Liver Centre, King's College London School of Medicine at King's College Hospital, Denmark Hill, London SE5 9PJ, UK.

Crigler-Najjar syndrome (CN), a rare inherited disorder characterized by failure of bilirubin glucuronidation, can lead to severe disability and death from kernicterus. Gilbert syndrome is a more common, benign familial unconjugated hyperbilirubinemia. The underlying problem in both conditions is impaired bilirubin conjugation and elimination due to a mutation in uridine 5'-diphosphate glucuronyltransferase. Read More

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http://dx.doi.org/10.1586/17446651.3.6.725DOI Listing
November 2008

Simultaneous laparoscopic left lateral sectionectomy and nephrectomy in the same living donor: The first case report.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, National Medical Research Center of Transplantology and Artificial Organs named after academician V.I. Shumakov, Moscow, Russian Federation.

With the presence of organ shortage, living donors remain important sources of grafts, especially for pediatric recipients. Laparoscopic nephrectomy has become the gold standard for living donors. Additionally, laparoscopic partial liver procurement in living donors has proven its safety and feasibility in the latest studies. Read More

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http://dx.doi.org/10.1111/ajt.15318DOI Listing
February 2019

Transplanting hepatitis C virus-infected hearts into uninfected recipients: A single-arm trial.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

The advent of direct-acting antiviral therapy for hepatitis C virus (HCV) has generated tremendous interest in transplanting organs from HCV-infected donors. We conducted a single-arm trial of orthotopic heart transplantation (OHT) from HCV-infected donors into uninfected recipients, followed by elbasvir/grazoprevir treatment after recipient HCV was first detected (NCT03146741; sponsor: Merck). We enrolled OHT candidates aged 40-65 years; LVAD support and liver disease were exclusions. Read More

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http://dx.doi.org/10.1111/ajt.15311DOI Listing
February 2019

A systematic review for variables to be collected in a transplant database for improving risk prediction.

Transplantation 2019 Feb 6. Epub 2019 Feb 6.

Evidence-Based Practice Research Program, Mayo Clinic, MN, USA.

Background: This systematic review was commissioned to identify new variables associated with transplant outcomes that are not currently collected by the Organ Procurement and Transplantation Network (OPTN).

Methods: We identified 81 unique studies including 1,193,410 patients with median follow-up of 36 months posttransplant, reporting 108 unique risk factors.

Results: Most risk factors (104) were recipient-related; few (4) were donor-related. Read More

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http://dx.doi.org/10.1097/TP.0000000000002652DOI Listing
February 2019

First approaches for the transplantation of hepatocytes from Wistar rat preneoplastic livers into healthy recipients.

Rev Esp Enferm Dig 2019 Feb 15. Epub 2019 Feb 15.

Área Morfología, Dto. Ciencias Fisiológicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Argentina.

Background: the shortage of donors of hepatocyte transplantation therapy led to the use of so-called marginal donors. Some donors may have a hepatic illnesses that is associated with hepatic preneoplasia with foci of altered hepatocytes (FAH).

Aims: to determine whether recipients developed FAH upon transplantation with hepatocytes from a preneoplastic liver and whether FAH progresses to a preneoplastic hepatocyte-derived tumor (PHDT), up to 60 days after transplantation. Read More

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http://dx.doi.org/10.17235/reed.2019.5830/2018DOI Listing
February 2019

The yield and safety of screening colonoscopy in patients evaluated for liver transplantation.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Hospital, Rotterdam, Netherlands.

Colorectal cancer screening with colonoscopy is commonly used in candidate patients for liver transplantation. We initiated this study to define the risk-benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre-liver transplantation screening between 2004-2017 was conducted. Read More

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http://dx.doi.org/10.1002/hep.30562DOI Listing
February 2019

An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis.

Hepatol Commun 2019 Feb 27;3(2):246-261. Epub 2018 Dec 27.

Division of Gastroenterology and Hepatology Saint Louis University St. Louis MO.

The presence and stage of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH) is strongly associated with mortality. Thus, both preventing and reversing fibrosis are critically important approaches to prevent death or the need for liver transplantation from NASH. Recently, fibrosis in several mouse models of organ injury was shown to be prevented and reversed with the potent small molecule, arginine-glycine-aspartic acid tripeptide (RGD)-binding, integrin antagonist (3S)-3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid (Center for World Health and Medicine [CWHM]-12). Read More

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http://dx.doi.org/10.1002/hep4.1298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357833PMC
February 2019

Acute Hepatic Porphyrias: Review and Recent Progress.

Hepatol Commun 2019 Feb 20;3(2):193-206. Epub 2018 Dec 20.

Section of Gastroenterology and Hepatology, Department of Internal Medicine Wake Forest University School of Medicine Winston-Salem NC.

The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms. The four types are 5-aminolevulinic acid (ALA) dehydratase deficiency porphyria, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. Their diagnoses are often missed or delayed because the clinical symptoms mimic other more common disorders. Read More

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http://dx.doi.org/10.1002/hep4.1297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357830PMC
February 2019

Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-B Signaling.

Biomed Res Int 2019 15;2019:1621854. Epub 2019 Jan 15.

Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University and Organ Transplantation Research Center of Guangdong Province, Guangzhou 510630, China.

Background: Inflammation is the major risk factor for the progression of hepatocellular carcinoma (HCC), and the nuclear factor-B (NF-B) signaling plays the central role in the inflammation process. However, the activated mechanism of NF-B signaling in HCC is unclear.

Methods: The expression of PHF5A is examined by qPCR, western blotting, and immunohistochemistry (IHC) assay. Read More

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http://dx.doi.org/10.1155/2019/1621854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350539PMC
January 2019

Managing the Silent Epidemic of Nonalcoholic Fatty Liver Disease.

Authors:
Michael Fuchs

Fed Pract 2019 Jan;36(1):12-13

is Chief of Hepatology and Liver Transplantation at Hunter Holmes McGuire VAMC in Richmond, Virginia. He also is a Professor of Medicine at Virginia Commonwealth University in Richmond.

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January 2019

Neurological Recovery After Recovery From Acute Liver Failure: Is it Complete?

J Clin Exp Hepatol 2019 Jan-Feb;9(1):99-108. Epub 2018 Jun 22.

Indraprastha Apollo Hospital, New Delhi, India.

Neurologic dysfunction characterised by Hepatic Encephalopathy (HE) and cerebral oedema are the most dramatic presentations of Acute Liver Failure (ALF) and signify poor outcome. Improved critical care and wider availability of emergency Liver Transplantation (LT) has improved survivability in ALF. In most cases absence of clinically overt encephalopathy after spontaneous recovery from ALF or after LT is thought to indicate complete neurologic recovery. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363962PMC

Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):74-98. Epub 2018 Sep 3.

Department of Pediatrics and Pediatric Liver GI and Nutrition Center and Mowat Labs, King's College Hospital, London, UK.

Clinical practice guidelines for Wilson's disease (WD) have been published by the American Association for the Study of Liver Diseases and European Association for the Study of the Liver in 2008 and 2012, respectively. Their focus was on the hepatic aspects of the disease. Recently, a position paper on pediatric WD was published by the European Society of Pediatric Gastroenterology Hepatology and Nutrition. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363961PMC
September 2018

Long Term Survival of Patients Undergoing TIPS in Budd-Chiari Syndrome.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):56-61. Epub 2018 Mar 1.

Consultant, Department of Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore.

Background: There has been significant improvement in understanding the etiology and management of Budd-Chiari Syndrome (BCS). Patients with chronic or acute-on-chronic BCS need radiological interventions in the form of angioplasty, hepatic vein/inferior vena cava stenting or Transjugular Intrahepatic Portosystemic Shunt (TIPS). Data regarding the long term follow up of patients undergoing TIPS is limited. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363956PMC

The Changing Face of Hepatocellular Carcinoma: Forecasting Prevalence of Nonalcoholic Steatohepatitis and Hepatitis C Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):50-55. Epub 2018 Feb 16.

Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA.

Background/objectives: The purpose of this research is to analyze the past and forecast the future prevalence of Hepatitis C Virus (HCV) and Nonalcoholic Steatohepatitis (NASH) and their respective contribution to Hepatocellular Carcinoma (HCC) incidence in the setting of novel anti-viral agents and rising obesity rates in the United States.

Methods: Existing data of HCV and NASH prevalence in the United States utilizing the National Health and Nutrition Examination Survey (NHANES) and Organ Procurement and Transplantation Network (OPTN) was collected and analyzed to project future prevalence trends.

Results: Prevalence of NASH and HCV are expected to increase and decline respectively over the next two decades with alcoholic cirrhosis expected to stay relatively unchanged. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363953PMC
February 2018

Combined morphological and functional liver MRI using spin-lattice relaxation in the rotating frame (T1ρ) in conjunction with Gadoxetic Acid-enhanced MRI.

Sci Rep 2019 Feb 14;9(1):2083. Epub 2019 Feb 14.

Department of Diagnostic and Interventional Radiology, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Noninvasive early detection of liver cirrhosis and fibrosis is essential for management and therapy. The aim was to investigated whether a combination of the functional parameter relative enhancement (RE) on Gadoxetic Acid magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and the fibrosis parameter T1ρ distinguishes cirrhosis and healthy liver. We analyzed patients with Gd-EOB-DTPA-enhanced MRI and T1ρ mapping. Read More

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http://dx.doi.org/10.1038/s41598-018-37689-yDOI Listing
February 2019

Laparoscopic versus open adhesiolysis for adhesive small bowel obstruction (LASSO): an international, multicentre, randomised, open-label trial.

Lancet Gastroenterol Hepatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Although laparoscopic adhesiolysis for adhesive small bowel obstruction is being done more frequently, it is not widely accepted due to the lack of supporting evidence of its superiority over an open approach and concerns regarding its benefits. We aimed to investigate whether laparoscopic adhesiolysis was a superior treatment for adhesive small bowel obstruction compared with an open approach in terms of length of postoperative hospital stay and morbidity.

Methods: In this international, multicentre, parallel, open-label trial, we randomly assigned patients (1:1) aged 18-95 years who had adhesive small bowel obstruction that had not resolved with conservative management to have either open or laparoscopic adhesiolysis. Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30016-0DOI Listing
February 2019

Long term outcomes of patients transplanted for hepatocellular carcinoma with human immunodeficiency virus infection.

HPB (Oxford) 2019 Feb 11. Epub 2019 Feb 11.

Department of Surgery - Transplant Division, University of Kentucky, College of Medicine, Lexington, KY, USA. Electronic address:

Background: We aimed to study outcomes in HIV + patients with HCC in the US following Liver Transplantation (LT) using the UNOS dataset.

Methods: The database was queried from 2003 to 2016 for patients undergoing LT with HCC, HIV+, and HCC/HIV+.

Results: Out of 17,397 LT performed for HCC during the study period, 113 were transplanted for HCC with HIV infection (91 isolated livers). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.01.001DOI Listing
February 2019

Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study.

Lancet 2019 Feb 11. Epub 2019 Feb 11.

AP-HP, Hôpital Cochin, Unité d'Hépatologie, Paris, France; Université Paris Descartes, INSERM U1223 and USM-20, Institut Pasteur, Paris, France.

Background: Although direct-acting antivirals have been used extensively to treat patients with chronic hepatitis C virus (HCV) infection, their clinical effectiveness has not been well reported. We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort.

Methods: We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32111-1DOI Listing
February 2019

Taxonomy, virulence genes and antimicrobial resistance of Aeromonas isolated from extra-intestinal and intestinal infections.

BMC Infect Dis 2019 Feb 14;19(1):158. Epub 2019 Feb 14.

Center of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Background: Clinical characteristics (taxonomy, virulence genes and antimicrobial resistance ) of Aeromonas in isolated from extra-intestinal and intestinal infections were investigated to describe epidemiology, associated virulence factors and optimal therapy options.

Methods: Clinical samples (n = 115) of Aeromonas were collected from a general hospital in Beijing between the period 2015 and 2017. Taxonomy was investigate by Multilocus phylogenetic analysis (MLPA), 10 putative virulence factors by use of polymerase chain reaction (PCR) and antimicrobial resistance to 15 antibiotics by use of the microbroth dilution method. Read More

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http://dx.doi.org/10.1186/s12879-019-3766-0DOI Listing
February 2019

Ultrastructure in Transthyretin Amyloidosis: From Pathophysiology to Therapeutic Insights.

Biomedicines 2019 Feb 5;7(1). Epub 2019 Feb 5.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Transthyretin (TTR) amyloidosis is caused by systemic deposition of wild-type or variant amyloidogenic TTR (ATTRwt and ATTRv, respectively). ATTRwt amyloidosis has traditionally been termed senile systemic amyloidosis, while ATTRv amyloidosis has been called familial amyloid polyneuropathy. Although ATTRwt amyloidosis has classically been regarded as one of the causes of cardiomyopathy occurring in the elderly population, recent developments in diagnostic techniques have significantly expanded the concept of this disease. Read More

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http://dx.doi.org/10.3390/biomedicines7010011DOI Listing
February 2019

Cardiac iron overload following liver transplantation in patients without hereditary hemochromatosis or severe hepatic iron deposition.

Cardiovasc Pathol 2019 Jan 3;40:7-11. Epub 2019 Jan 3.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. Electronic address:

Background: Cardiac iron overload following liver transplantation in patients without hemochromatosis but with severe hepatic iron deposition has been reported to result in heart failure and/or death in case reports and small case series. However, the frequency and causes of cardiac iron overload following liver transplantation and its relationship to cardiac dysfunction in patients without severe hepatic iron deposition are unclear.

Methods: The primary inclusion criteria for this study were liver transplantation followed by autopsy or cardiac transplantation within 1 year. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.008DOI Listing
January 2019

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.

PLoS One 2019 14;14(2):e0211916. Epub 2019 Feb 14.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Objectives: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211916PLOS
February 2019

Reply to HEP-17-1319.

Authors:
Anna S Lok

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.

We are disappointed that the Cochrane Group remains unconvinced that sustained virologic response (SVR) is a validated surrogate outcome and that direct-acting antiviral agents (DAAs) have been demonstrated to improve clinical as well as patient-reported outcomes in patients with chronic hepatitis C. Since our commentary in 2017, there have been many more studies supporting the benefits of SVR and DAA therapies, including a decline in patients added to the waiting list for liver transplantation for hepatitis C. We recognize that randomized controlled trials are the gold standards for showing the benefits of new treatments but given the robust evidence from clinical trials and observational studies all over the world, we do not believe that it is ethical to contemplate withholding clinically proven beneficial therapy. Read More

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http://dx.doi.org/10.1002/hep.30564DOI Listing
February 2019

Solitary nasopharynx metastasis from hepatocellular carcinoma after liver transplantation: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14368

Rationale: Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths worldwide. Nasopharyngeal metastasis of hepatocellular carcinoma is very rare. This is the first report of posttransplantation nasopharyngeal metastasis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014368DOI Listing
February 2019

Current status of graft-versus-host disease after intestinal transplantation.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Transplantation, Department of Surgery, Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Thomas E. Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Purpose Of Review: Over the past decades, visceral transplantation has become the standard of care for patients with irreversible intestinal failure who suffer complications of total parenteral nutrition (TPN). Graft-versus-host disease (GVHD) after solid organ transplantation is a rare but often fatal complication with high mortality. GVHD after intestinal transplantation, given the large lymphoid content of the graft, is more frequent compared with other solid organs. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000624DOI Listing
February 2019
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Contemporary management of hepatoblastoma.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Purpose Of Review: Hepatoblastoma is the most common primary pediatric liver malignancy. The goal of treatment in hepatoblastoma is complete surgical resection. Recently published multinational collaborative studies are better defining risk factors for disease recurrence and guide optimal treatment strategy. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000618DOI Listing
February 2019

Intraoperative anesthetic management of the liver transplant recipient with portopulmonary hypertension.

Authors:
Sherif Kandil

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Department of Anesthesiology, Keck Medical School of USC, Los Angeles, California, USA.

Purpose Of Review: Liver transplantation in patients with portopulmonary hypertension (POPH) is associated with increased perioperative risk. Important recent advances in the management of liver transplantation recipients with POPH are discussed.

Recent Findings: The presence of POPH at the time of liver transplantation should not be a contraindication for liver transplantation, as POPH is common and may be related to volume overload and/or high cardiac output (CO). Read More

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http://dx.doi.org/10.1097/MOT.0000000000000613DOI Listing
February 2019

More Severe Deficits in Performance Status at Time of Liver Transplant is Associated With Significantly Higher Risk of Death Following Liver Transplantation.

J Clin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, CA.

Goal: To evaluate the impact of Karnofsky Performance Status score (KPSS) at the time of liver transplantation (LT) on post-LT survival.

Background: While the Model for End-Stage Liver Disease (MELD) score is used to prioritize individuals for LT, it does not specifically incorporate functional status into patient assessment for LT.

Methods: Using 2005 to 2016 United Network for Organ Sharing data, all adults (age 18 y and above) undergoing LT were identified. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001187DOI Listing
February 2019
3.498 Impact Factor

Efficient Generation of an Fah/Rag2 Dual-Gene Knockout Porcine Cell Line Using CRISPR/Cas9 and Adenovirus.

DNA Cell Biol 2019 Feb 14. Epub 2019 Feb 14.

1 Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHFPC, West China Hospital, Sichuan University, Chengdu, China.

The shortage of human hepatocytes continues to be a significant limitation for the widespread application of hepatocyte transplantation and bioartificial liver (BAL) support therapy. Recombinant activation gene 2 (Rag2) and fumarylacetoacetate hydrolase (Fah)-deficient mice could be highly repopulated with human hepatocytes. However, Fah/Rag2-deficient mice can only produce up to 1 × 10 human hepatocytes per mouse. Read More

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http://dx.doi.org/10.1089/dna.2018.4493DOI Listing
February 2019

Cholangiocarcinoma is associated with a raised enhanced liver fibrosis (ELF) score independent of primary sclerosing cholangitis.

Eur J Clin Invest 2019 Feb 14:e13088. Epub 2019 Feb 14.

Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom.

Background: Cholangiocarcinoma (CCA) complicates primary sclerosing cholangitis (PSC) in 10-20% of cases, but current tools for prediction of a CCA diagnosis are inadequate. Recently we demonstrated the utility of the ELF test to stratify prognosis in PSC. We observed that patients with PSC+CCA had significantly higher ELF score than those with PSC alone. Read More

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http://dx.doi.org/10.1111/eci.13088DOI Listing
February 2019

The investigation of Strongyloides stercoralis seroprevalence in immunosupressed patients in Turkey

Turk J Med Sci 2019 Feb 11;49(1):16-19. Epub 2019 Feb 11.

Background/aim: In immunosuppressed patients, strongyloidiasis can be lifethreatening because of hyperinfection or dissemination. Therefore, diagnosis of S. stercoralis is important in immunosuppressed patients with chronic strongyloidiasis. Read More

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http://dx.doi.org/10.3906/sag-1804-16DOI Listing
February 2019

Multidrug-Resistant Accelerate Intestinal, Extra-Intestinal, and Systemic Inflammatory Responses in Human Microbiota-Associated Mice With Subacute Ileitis.

Front Immunol 2019 29;10:49. Epub 2019 Jan 29.

Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Berlin Institute of Health, Charité - University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

The globally rising incidences of multidrug-resistant (MDR) (Psae) in humans and live-stock animals has prompted the World Health Organization to rate MDR Psae as serious threat for human health. Only little is known, however, regarding factors facilitating gastrointestinal Psae-acquisition by the vertebrate host and subsequently induced inflammatory sequelae. In the present study, we addressed whether subacute ileitis predisposed mice harboring a human gut microbiota for intestinal MDR Psae carriage and whether inflammatory responses might be induced following peroral challenge with the opportunistic pathogen. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361842PMC
January 2019

Irreversible Electroporation as a Bridge to Liver Transplantation.

Am Surg 2019 Jan;85(1):103-110

Hepatocellular carcinoma (HCC) in proximity to major hepatic vasculature poses a risk for invasion, which would contraindicate liver transplantation, yet, is difficult to treat with thermal ablation. This study was undertaken to evaluate the feasibility of irreversible electroporation (IRE) as a bridge to transplantation for high-risk tumors. All patients with HCC in proximity to major hepatic vasculature treated with laparoscopic IRE as bridge to transplantation were studied. Read More

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January 2019

The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells.

Stem Cell Res Ther 2019 Feb 13;10(1):53. Epub 2019 Feb 13.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include the potential for growing tissues and organs in the laboratory and transplanting them when the body cannot heal itself. However, several obstacles remain to be overcome in order to bring regenerative medicine approach for diabetes closer to its clinical implementation; the cells generated in vitro are typically of heterogenic and immature nature and the site of implantation should be readily vascularized for the implanted cells to survive in vivo. Read More

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http://dx.doi.org/10.1186/s13287-019-1157-5DOI Listing
February 2019

A New Mutation Causing Progressive Familiar Intrahepatic Cholestasis Type 3 in Association with Autoimmune Hepatitis.

Eur J Case Rep Intern Med 2017 27;4(2):000537. Epub 2017 Mar 27.

Liver and Pancreatic Transplantation Unit, Centro Hospitalar do Porto - Hospital de Santo António, Porto, Portugal.

Background: Some patients exhibit features of both autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). Similarly, patients with progressive familial intrahepatic cholestasis type 3 (PFIC3) may share histological features with PSC.

Case Report: We report the case of a 22-year-old man who, since he was 5 years of age, has presented with pruritus, an approximately ninefold elevation of aminotransferases, and γ-glutamyl transferase levels ~10 times the upper limit. Read More

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http://dx.doi.org/10.12890/2016_000537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346900PMC

A Diagnosis of Inflammatory Pseudotumor of the Liver by Contrast Enhaced Ultrasound and Fine-Needle Biopsy: A Case Report.

Eur J Case Rep Intern Med 2017 27;4(2):000495. Epub 2017 Mar 27.

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari, Policlinico, Bari, Italy.

Inflammatory pseudotumor (IPT) of the liver is a rare, benign lesion of unclear etiology, which may be misdiagnosed as hepatocellular carcinoma, cholangiocarcinoma, secondary tumor or abscess, because of its non-specific clinical, biochemical and radiologic findings. We present the case of a 48-old-year male in whom diagnosis of liver IPT was suspected by contrast enhanced ultrasound (CEUS) and confirmed by fine-needle liver biopsy. The diagnosis is in contrast to most of the literature reports in which the diagnosis was made only based on a surgical specimen. Read More

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http://dx.doi.org/10.12890/2016_000495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346893PMC

Repeated Treatment with Y-Microspheres in Intrahepatic Cholangiocarcinoma Relapsed After the First Radioembolization.

Cancer Biother Radiopharm 2019 Feb 13. Epub 2019 Feb 13.

1 Department of Nuclear Medicine, Santa Maria Goretti Hospital, Latina, Italy.

Background: The aim of this study was to evaluate the safety and efficacy of repeated administration of Y-microspheres in intrahepatic cholangiocarcinoma (ICC) relapsed after the first radioembolization (RE).

Methods: Nine patients with ICC relapsed after the first Y-RE were enrolled. Six patients presented recurrence in the right hepatic lobe, 3 in the left lobe. Read More

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http://dx.doi.org/10.1089/cbr.2018.2718DOI Listing
February 2019

Kcne4 deletion sex-dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 13. Epub 2019 Feb 13.

Dept. of Pharmacology, University of California, Irvine, United States.

Activation of anti-apoptotic signaling cascades such as the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways is protective in a variety of tissues in the context of ischemia reperfusion (IR) injury. Hepatic IR injury causes clinically significant hepatocellular damage in surgical procedures including liver transplantation and hepatic resection, increasing associated morbidity and mortality. We previously found that the cardiovascular-expressed potassium channel ancillary subunit, KCNE4, sex-specifically influences the cardiac RISK/SAFE pathway response to IR, and that Kcne4 deletion testosterone-dependently exacerbates cardiac IR injury. Read More

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http://dx.doi.org/10.1152/ajpregu.00251.2018DOI Listing
February 2019

A new extra-thoracic, in-plane, longitudinal, real-time, ultrasound-guided access to the axillary vein.

Intensive Care Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Henri Mondor Hospital, Créteil, France.

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http://dx.doi.org/10.1007/s00134-019-05561-wDOI Listing
February 2019