101,630 results match your criteria Liver Transplantation


Impact of diagnosis and therapy on cognitive function in urea cycle disorders.

Ann Neurol 2019 Apr 24. Epub 2019 Apr 24.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Objective: Individuals with urea cycle disorders (UCDs) often present with intellectual and developmental disabilities. The major aim of this study was to evaluate the impact of diagnostic and therapeutic interventions on cognitive outcomes in UCDs.

Methods: This prospective, observational, multicenter study includes data from 503 individuals with UCDs who had comprehensive neurocognitive testing with a cumulative follow-up of 702 patient-years. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25492
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http://dx.doi.org/10.1002/ana.25492DOI Listing
April 2019
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Outcomes of Liver Transplantation for Acute Fatty Liver Disease of Pregnancy.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

University of California, San Francisco, San Francisco, California.

Acute fatty liver of pregnancy (AFLP) often resolves after pregnancy delivery but can progress to acute liver failure necessitating liver transplantation. We performed a retrospective review of the national Scientific Registry of Transplant Recipients (SRTR) data to identify all women in the United States undergoing liver transplantation (LT) for acute liver failure (ALF) from AFLP from 1991 to 2015, and compared to outcomes in women of childbearing age undergoing transplant for ALF from acetaminophen and ALF from other etiologies. Women with AFLP were likely to be on life support at time of LT and had high rates of renal dysfunction (median Cr 2. Read More

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http://dx.doi.org/10.1111/ajt.15401DOI Listing

Primary liver graft dysfunction and non-function: integrative literature review.

Rev Col Bras Cir 2019 18;46(1):e2039. Epub 2019 Apr 18.

Universidade Federal de Minas Gerais, Escola de Enfermagem, Belo Horizonte, MG, Brasil.

Avoiding deaths in the waiting list for an organ is no longer the only focus of the transplant teams attention. Research and care in clinical practice has been increasingly focused on post transplant graft survival and functioning. In the present work, we performed an integrative literature review to identify the terminology used about liver graft dysfunction and non-function, as well as to investigate the incidence and risk factors of these clinical events. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192039DOI Listing

Successful percutaneous treatment of biliary stenosis after living donor liver transplantation in a child.

Radiol Case Rep 2019 Jul 15;14(7):800-804. Epub 2019 Apr 15.

Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen, 9700 RB, The Netherlands.

We report the case of a 16-year-old boy with primary clerosing holangitis associated with inflammatory bowel disease who was initially treated and controlled pharmacologically. He underwent living donor liver transplantation (LDLT) after he developed progressive biliary tract abnormalities and portal hypertension accompanied by recurrent bile duct infections. Two months following LDLT, the hepaticojejunostomy anastomosis became occluded and it was treated surgically. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468169PMC

Role of Allelic Imbalance in Predicting Hepatocellular Carcinoma (HCC) Recurrence Risk After Liver Transplant.

Ann Transplant 2019 Apr 24;24:223-233. Epub 2019 Apr 24.

Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.

BACKGROUND One of the most controversial problems for liver transplantation in patients affected by hepatocellular carcinoma (HCC) remains the lack of an oncologic staging system to predict cancer recurrence after liver transplantation (LT). We analyzed allelic imbalance (AI) in 19 microsatellites, and assessed the post-LT HCC recurrence risk. MATERIAL AND METHODS Seventy-one patients were included; 18 had tumor recurrence within 5 years post-transplant. Read More

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http://dx.doi.org/10.12659/AOT.913692DOI Listing

The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation.

Liver Transpl 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.

The evolution of nurse practitioners (NP) and physician assistants (PA) in the United States continues to progress. NPs and PAs have expanded from primary care practices, to medical and surgical specialties, provide acute care in hospitals and intensive care units, and serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice. Read More

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http://dx.doi.org/10.1002/lt.25474DOI Listing

The gut-liver axis in PSC: Are pathobionts the missing link?

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.

Primary sclerosing cholangitis (PSC) is characterized by progressive fibrosis around intra- and extrahepatic bile ducts that can progress to cirrhosis and liver failure. There are no regulatory drugs approved for PSC and liver transplantation is the only effective therapy(1). While the concentric accumulation of periductular fibrosis suggests the biliary epithelial cell (cholangiocyte) plays an integral role in disease initiation and/or progression, multiple factors from the gut like microbes and their molecular products, endogenous metabolites like bile acids, and primed immune cells have been hypothesized to play a significant role in the hepatobiliary injury and adverse clinical sequelae in PSC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30673
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http://dx.doi.org/10.1002/hep.30673DOI Listing
April 2019
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The 2016 ASE/EACVI recommendations may be able to more accurately identify patients at risk for diastolic dysfunction in living donor liver transplantation.

PLoS One 2019 23;14(4):e0215603. Epub 2019 Apr 23.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: The aim of this study was to compare the prevalence of diastolic dysfunction between the 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging and 2009 ASE/European Association of Echocardiography recommendations in patients undergoing living-donor liver transplantation (LDLT).

Patients And Methods: A total of 312 adult patients who underwent LDLT at our hospital from January 2010 to December 2017 were retrospectively analyzed. Exclusion criteria were systolic dysfunction, arrhythmia, myocardial ischemia, and mitral or aortic valvular insufficiency. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215603PLOS

Predictor Parameters of Liver Viability During Porcine Nomothermic Ex-Situ Liver Perfusion in a Model of Liver Transplantation with Marginal Grafts.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.

Normothermic ex-situ liver perfusion(NEsLP) offers the opportunity to assess biomarkers of graft function and injury. We investigated NEsLP parameters(biomarkers and markers) for the assessment of liver viability in a porcine transplantation model. Grafts from heart beating donors(HBD), and from donors with 30'(DCD30'), 70'(DCD70') and 120'(DCD120') of warm ischemia were studied. Read More

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http://dx.doi.org/10.1111/ajt.15395DOI Listing

Fatal diffuse pulmonary fat microemboli following reperfusion in liver transplantation with the use of marginal steatotic allografts.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Phoenix, Arizona.

Organ shortage is a major cause of delayed liver transplantation and increased wait list time. The level of donor steatosis is a significant determinant in organ selection. Scarcity of organs has led some programs to expand their acceptable criteria for the percentage of steatosis. Read More

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http://dx.doi.org/10.1111/ajt.15399DOI Listing

Time for Reform in Transplant Program Specific Reporting - AST/ASTS Transplant Metrics Taskforce.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplantation, University of Minnesota, Minneapolis, Minnesota.

In accordance with the National Organ Transplant Act and HHS's Final Rule, the Scientific Registry of Transplant Recipients (SRTR) publicly releases biannual program-specific reports which include analyses of transplant centers' risk-adjusted wait-list mortality, organ acceptance ratios, transplant rates, and graft and patient survival. Since the inception of these center metrics, one-year post-transplant graft and patient survival have improved, and center variation has decreased, casting uncertainty on their clinical relevance. The SRTR has recently modified center evaluations by ranking centers into 5 tiers rather than 3-tiers in an attempt to discriminate between programs performing within a tight range, further exacerbating this uncertainty. Read More

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http://dx.doi.org/10.1111/ajt.15394DOI Listing

ABO-Incompatible Liver Transplantation - A Review of the Historical Background and Results.

Int Rev Immunol 2019 Apr 23:1-11. Epub 2019 Apr 23.

a Transplant Institute, Sahlgrenska University Hospital, Sahlgrenska Academy , Gothenburg , Sweden.

ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive protocols which have made the outcome after living donor (LD) ABOi LT equivalent to that achieved with LD ABO-compatible (ABOc). The experience of deceased donor (DD) ABOi LT is however still limited. Read More

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http://dx.doi.org/10.1080/08830185.2019.1601720DOI Listing

Use of genetic risks in pediatric organ transplantation listing decisions: A national survey.

Pediatr Transplant 2019 Apr 23:e13402. Epub 2019 Apr 23.

Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford University, Stanford, California.

There is a limited supply of organs for all those who need them for survival. Thus, careful decisions must be made about who is listed for transplant. Studies show that manifesting genetic disease can impact listing eligibility. Read More

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http://dx.doi.org/10.1111/petr.13402DOI Listing

Hepatic artery reconstruction with interposition of donor's right gastroepiploic artery graft in pediatric living donor liver transplantation for metabolic disease.

Pediatr Transplant 2019 Apr 23:e13418. Epub 2019 Apr 23.

Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: We introduce the indications, technique, results of our experience using donor's RGEA as interposition vessel to solve hepatic artery reconstruction problems in P-LDLT.

Methods: A retrospective analysis of P-LDLT for children with metabolic diseases from June 2013 to November 2018 in our center was carried out. The arterial conditions, reconstruction methods, and prognosis were analyzed. Read More

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http://dx.doi.org/10.1111/petr.13418DOI Listing

Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

Pediatr Transplant 2019 Apr 23:e13420. Epub 2019 Apr 23.

Department of Clinical Hematology, Royal Children's Hospital, Parkville, Victoria, Australia.

Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children post-liver transplant, with comparison to our institution's experience. Read More

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http://dx.doi.org/10.1111/petr.13420DOI Listing

Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report.

Pediatr Transplant 2019 Apr 23:e13410. Epub 2019 Apr 23.

Liver Transplant Program, University of Minnesota Masonic Children's Hospital, University of Minnesota, Minneapolis, Minnesota.

Hepatic angiosarcoma is an extremely rare diagnosis in children, with fewer than 50 pediatric cases reported in the literature worldwide. This aggressive vascular sarcoma carries a very dismal prognosis and is known to be resistant to radiation, chemotherapy, and other vascular-targeted agents. Complete surgical resection is felt to provide the best chance for long-term survival. Read More

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http://dx.doi.org/10.1111/petr.13410DOI Listing

Resident Operative Experience in Hepatopancreatobiliary Surgery: Exposing the Divide.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Cincinnati Research on Education in Surgical Training (CREST), Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 0558, Cincinnati, OH, 45267-0558, USA.

Background: The Accreditation Council for Graduate Medical Education (ACGME) requires an experience in hepatopancreatobiliary (HPB) surgery as part of general surgery residency training. The composition of this experience, however, is unclear. We set out to evaluate current trends in the HPB experience of US general surgery residents. Read More

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http://dx.doi.org/10.1007/s11605-019-04226-9DOI Listing

Effective and Safe Living Donor Hepatectomy Under Intermittent Inflow Occlusion and Outflow Pressure Control.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1007/s11605-019-04196-yDOI Listing

Plasma transfusion combined with chelating therapy alleviates fulminant Wilson's disease with a single Arg778Leu heterozygote mutation.

Ann Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, Jiangsu 213000, China; Department of Liver Diseases, The Third People's Hospital of Changzhou, Changzhou, Jiangsu 213000, China. Electronic address:

Wilson's disease (WD), resulting from homozygote and compound heterozygote mutations in ATB7B, is an autosomal recessive disease. WD associated acute liver failure (ALF) is fatal, and a revised Wilson's disease prognostic index (RWPI) >11 is a reliable indication of liver transplantation (LT) or artificial liver support (ALS). We described a WD patient who initially presented with ALF and severe hemolytic anemia. Read More

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http://dx.doi.org/10.1016/j.aohep.2018.07.001DOI Listing

Prioritization for liver transplantation using the MELD score in Chile: Inequities generated by MELD exceptions.: A collaboration between the Chilean Liver Transplant Programs, the Public Health Institute and the National Transplant Coordinator.

Ann Hepatol 2019 Apr 12. Epub 2019 Apr 12.

National Liver Transplant Coordinator, Santiago, Chile. Electronic address:

Introduction And Aim: The MELD score has been established as an efficient and rigorous prioritization system for liver transplant (LT). Our study aimed to evaluate the effectiveness of the MELD score as a system for prioritization for LT, in terms of decreasing the dropout rate in the waiting list and maintaining an adequate survival post-LT in Chile.

Materials And Methods: We analyzed the Chilean Public Health Institute liver transplant registry of candidates listed from October 15th 2011 to December 31st 2014. Read More

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http://dx.doi.org/10.1016/j.aohep.2018.11.001DOI Listing
April 2019
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Cerebral autoregulation in a fulminant hepatic failure patient who underwent liver transplantation.

Ann Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Laboratory for Neurosonology and Cerebral Hemodynamics, Division of Neurological Surgery, Hospital das Clinicas, Sao Paulo University Medical School, Brazil.

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http://dx.doi.org/10.1016/j.aohep.2018.07.002DOI Listing
April 2019
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Recent updates on alcoholic hepatitis.

Dig Liver Dis 2019 Apr 19. Epub 2019 Apr 19.

Division of Gastroenterology and Hepatology, University of South Dakota, Avera McKennan University Health Center and Transplant Institute, Sioux Falls, SD 57105, United States. Electronic address:

Alcoholic hepatitis (AH) is a unique clinical syndrome that affects patients with chronic and active harmful alcohol consumption, and is associated with a high mortality of up to 40% at 1 month from presentation. It is important to assess disease severity and prognosis at time of presentation to identify patients at risk for high mortality and potential candidates for specific therapies. The cornerstone therapy for AH is enteral nutrition and abstinence. Read More

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http://dx.doi.org/10.1016/j.dld.2019.03.023DOI Listing

Portal Vein Stent Placement in Living-donor Liver Transplantation: A Single-center Experience.

Transplant Proc 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Introduction: Portal vein thrombosis (PVT) and portal vein stenosis (PVS) are rare complications after liver transplantation that can lead to graft failure and patient death.

Material And Methods: The aim of this study was to evaluate the effect of interventional treatment for PVT and PVS occlusion after liver transplantation. Follow-up data of 7 patients who underwent stent replacement for PVT and/or PVS were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183170
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http://dx.doi.org/10.1016/j.transproceed.2019.01.123DOI Listing
April 2019
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Antibodies against Angiotensin II Type 1 and Endothelin A Receptors: Relevance and pathogenicity.

Hum Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Antibodies against two G-protein coupled receptors (GPCRs), angiotensin II type 1 receptor (AT1R) and endothelin A receptor (ETAR) are among a growing number of autoantibodies that are found to be associated with allograft dysfunction. AT1R antibodies (AT1Rabs) and ETAR antibodies (ETARabs) have been shown to activate their target receptors and affect signaling pathways. Multiple single center reports have shown an association between presence of these antibodies and acute or chronic rejection and graft loss in kidney, heart, liver, lung and composite tissue transplantations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859193013
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http://dx.doi.org/10.1016/j.humimm.2019.04.012DOI Listing
April 2019
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Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview.

Int J Mol Sci 2019 Apr 20;20(8). Epub 2019 Apr 20.

Department of Clinical and Molecular Medicine, University of Catania, Catania 95100, Italy.

Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in developed countries but its diffusion is currently also emerging in Asian countries, in South America and in other developing countries. It is progressively becoming one of the main diseases responsible for hepatic insufficiency, hepatocarcinoma and the need for orthotopic liver transplantation. NAFLD is linked with metabolic syndrome in a close and bidirectional relationship. Read More

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https://www.mdpi.com/1422-0067/20/8/1948
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http://dx.doi.org/10.3390/ijms20081948DOI Listing
April 2019
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Balancing the risk and rewards of utilizing organs from hepatitis C viremic donors.

Curr Opin Organ Transplant 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Liver Center, Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Owing to long waitlist times and high waitlist morbidity and mortality, strategies to increase utilization of hepatitis C viremic-deceased donor organs are under investigation in kidney, liver, heart, and lung transplantation.

Recent Findings: Direct-acting antiviral medications for hepatitis C virus infection have high cure rates and are well tolerated. Small, single-center trials in kidney and heart transplant recipients have demonstrated that with early posttransplant direct-acting antiviral therapy, 100% of uninfected recipients of hepatitis C viremic organs have been cured of infection after transplantation. Read More

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http://Insights.ovid.com/crossref?an=00075200-900000000-9903
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http://dx.doi.org/10.1097/MOT.0000000000000651DOI Listing
April 2019
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Racial, Ethnic, and Socioeconomic Disparities in Web-Based Patient Portal Usage Among Kidney and Liver Transplant Recipients: Cross-Sectional Study.

J Med Internet Res 2019 Apr 22;21(4):e11864. Epub 2019 Apr 22.

Department of Medicine, Emory University, Atlanta, GA, United States.

Background: Kidney and liver transplant recipients must manage a complex care regimen after kidney transplant. Although the use of Web-based patient portals is known to improve patient-provider communication and health outcomes in chronic disease populations by helping patients manage posttransplant care, disparities in access to and use of portals have been reported. Little is known about portal usage and disparities among kidney and liver transplant recipients. Read More

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http://dx.doi.org/10.2196/11864DOI Listing

Long-term results of liver transplantation for polycystic liver disease: Single-center experience in China.

Exp Ther Med 2019 May 27;17(5):4183-4189. Epub 2019 Mar 27.

Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China.

The aim of the present study was to explore the indications for and safety of orthotopic liver transplantation for polycystic liver disease (PLD). Orthotopic liver transplantation in 11 patients with PLD between May 2004 and September 2013 was retrospectively analyzed. Patient epidemiological, clinical and follow-up data were collected. Read More

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http://dx.doi.org/10.3892/etm.2019.7449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468458PMC

Impact of donor age on liver regeneration and function following adult living donor liver transplantation.

Exp Ther Med 2019 May 29;17(5):3965-3970. Epub 2019 Mar 29.

Department of Radiology, Tianjin First Center Hospital, Tianjin 300192, P.R. China.

The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7454
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http://dx.doi.org/10.3892/etm.2019.7454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468505PMC
May 2019
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Brain metabolic alterations in patients with long-term calcineurin inhibitor therapy after liver transplantation.

Aliment Pharmacol Ther 2019 Apr 21. Epub 2019 Apr 21.

Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.

Background: Calcineurin inhibitor (CNI) neurotoxicity after liver transplantation might be due to impairment of the cerebral metabolism.

Aims: To investigate CNI-related alterations of brain metabolite distributions and associations between cognitive function and brain metabolism in patients with long-term CNI treatment after liver transplantation.

Methods: Eighty-two patients (19 CNI free, 34 CNI low-dose and 29 standard-dose CNI immunosuppression) 10 years after liver transplantation and 32 adjusted healthy controls underwent nonlocalised brain phosphorus magnetic resonance spectroscopy (MRS) and single voxel proton MRS in the parietal white matter to estimate brain metabolite contents. Read More

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http://dx.doi.org/10.1111/apt.15256DOI Listing

Hepatobiliary scintigraphy in the study of complications in adult patients after liver transplant. Description of the experience.

Rev Esp Med Nucl Imagen Mol 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Medicina Nuclear, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia. Electronic address:

Objective: To show the experience of the use of hepatobiliary scintigraphy in patients with suspected complications after liver transplantation in a high complexity centre.

Material And Method: Retrospective, observational and descriptive study. All consecutive adult patients with liver transplantation between January 2013 and February 2018 were included, with one or more hepatobiliary scintigraphy during the early or late postoperative period. Read More

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http://dx.doi.org/10.1016/j.remn.2019.02.006DOI Listing

Sarcopenia: Ammonia metabolism and hepatic encephalopathy.

Clin Mol Hepatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and adversely affects the quality of life; cirrhosis related liver decompensation and significantly decreases wait-list and post-liver transplantation survival. The main therapeutic strategies to improve or reverse sarcopenia include dietary interventions (supplemental calorie and protein intake), increased physical activity (supervised resistance and endurance exercises), hormonal therapy (testosterone), and ammonia lowering agents (L-ornithine L-aspartate, branch chain amino acids) as well as mechanistic approaches that target underlying molecular and metabolic abnormalities. Besides other factors, hyperammonemia has recently gained attention and increase sarcopenia by various mechanisms including increased expression of myostatin, increased phosphorylation of eukaryotic initiation factor 2a, cataplerosis of α ketoglutarate, mitochondrial dysfunction, increased reactive oxygen species that decrease protein synthesis and increased autophagy-mediated proteolysis. Read More

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http://dx.doi.org/10.3350/cmh.2019.0015DOI Listing

Appropriate treatment modality for solitary small hepatocellular carcinoma: Radiofrequency ablation vs. Resection vs. Transplantation?

Clin Mol Hepatol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Keimyung University Dongsan Medical Center, Daegu, Korea.

There has been controversy regarding the first-line treatment modality for the patients who have small solitary hepatocellular carcinoma (HCC); radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI), surgical hepatic resection (HR) and liver transplantation (LT). For selection of treatment modality of HCC, it should be considered of hepatic reservoir function as well as the tumor stage. If the liver function is good enough, HR may be the first choice regardless of the tumor size. Read More

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http://dx.doi.org/10.3350/cmh.2018.0096DOI Listing

Disseminated Trichosporon asahii infection in a combined liver-kidney transplant recipient successfully treated with voriconazole.

Immun Inflamm Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Infectious Disease, Medanta The Medicity, Gurgaon, Haryana, India.

Introduction: Trichosporon asahii is an emerging cause of systemic fungal infection in an immunocompromised host. Several life threatening disseminated T. asahii infection in single solid organ (liver or kidney) transplant recipients, in neutropenic and hematological malignancy patients have been reported. Read More

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http://dx.doi.org/10.1002/iid3.250DOI Listing

Long-term Outcome of Percutaneous Transhepatic Biliary Drainage for Biliary Strictures Following Pediatric Liver Transplantation.

Clin Transplant 2019 Apr 21:e13570. Epub 2019 Apr 21.

Department of Transplant Surgery, Jichi Medical University.

Background: We present a retrospective analysis of our experience with pediatric liver transplantation (LT), focusing on the long-term outcome of percutaneous transhepatic biliary drainage (PTBD) for post-transplant biliary strictures.

Methods: Fifty-three PTBDs were performed for 41 pediatric recipients with biliary strictures. The median ages at LT and PTBD were 1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13570
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http://dx.doi.org/10.1111/ctr.13570DOI Listing
April 2019
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Factors Predicting Kidney Delayed Graft Function Among Recipients of Simultaneous Liver-Kidney Transplantation: Single Center Experience.

Clin Transplant 2019 Apr 21:e13569. Epub 2019 Apr 21.

Division of Transplantation and Hepatobiliary Surgery, University of Florida, FL, USA.

Background: Kidney delayed graft function (kDGF) remains a challenging problem following simultaneous liver and kidney transplantation (SLKT) with a reported incidence up to 40%. Given the scarcity of renal allografts, it is crucial to minimize the development of kDGF among SLKT recipients to improve patient and graft outcomes. We sought to assess the role of preoperative recipient and donor/graft factors on developing kDGF among recipients of SLKT. Read More

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http://dx.doi.org/10.1111/ctr.13569DOI Listing
April 2019
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Untargeted gas chromatography-mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 12;1118-1119:25-32. Epub 2019 Apr 12.

Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia; Metabolomics Australia, Western Australia Node, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia.

Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed for the development of new, less invasive treatments. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.021DOI Listing

Outcome of kidney transplantation from young pediatric donors (aged less than 6 years) to young size-matched recipients.

J Pediatr Urol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Nephrology, University Hospital Vall d'Hebron, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain; School of Medicine, Universitat Autonoma de Barcelona, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain.

Introduction: Pediatric donation is underutilized because of presumed increased risk of vascular thrombosis (VT) and graft loss. Using young pediatric donors (YPDs) for young pediatric recipients (YPRs) is suggested to be even at greater risk and therefore precluded in many centers. The aim of this study was to analyze the outcome of kidney transplantation (KT) from YPD to age-matched YPR. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.015DOI Listing
March 2019
2 Reads

Feasibility and safety of liver transplantation or resection after transarterial radioembolization with Yttrium-90 for unresectable hepatocellular carcinoma.

HPB (Oxford) 2019 Apr 17. Epub 2019 Apr 17.

Department of Visceral Surgery, Lausanne University Hospital CHUV, Switzerland; Department of Liver Surgery, Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: The benefit of transarterial radioembolization (TARE) in patients with unresectable hepatocellular carcinoma (HCC) is increasingly evidenced. However, data on outcome of liver transplantation or resection after TARE remain scarce. This study aimed to assess the safety and feasibility of surgery after TARE in patients with unresectable HCC. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.360DOI Listing

Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children.

Kidney Int 2019 Mar 20. Epub 2019 Mar 20.

Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.035DOI Listing

Comparison of Two Thrombin Generation Methods, CAT and ST-Genesia, in Liver Transplant Patients.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

CHU Bordeaux, Laboratoire d'Hématologie - PTRR, Hôpital Pellegrin, Bordeaux, France.

Background:  During liver transplantation (LT), thrombin generation (TG) is altered. The most frequently used assay for TG is the Calibrated Automated Thrombogram (CAT). It is designed for series of plasmas and is semi-automated. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685452
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http://dx.doi.org/10.1055/s-0039-1685452DOI Listing
April 2019
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Increased Risk of Death in First Year After Liver Transplantation Among Patients with Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Gastroenterology, Henry Ford Hospital, Detroit, Michigan, United States.

Background & Aims: An increasing number of patients with non-alcoholic steatohepatitis (NASH) require liver transplantation. We compared outcomes of patients with liver diseases of different etiologies (NASH, hepatitis C virus [HCV]-associated liver disease, and alcohol-associated liver disease [ALD]).

Methods: We analyzed data from the United Network for Organ Sharing registry on 6344 patients who underwent liver transplantation for NASH, 17,037 for cirrhosis from chronic HCV infection, and 9279 for ALD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.033DOI Listing
April 2019
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Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma via the miR-338-3p/PKM2 axis under hypoxic stress.

Hepatology 2019 Apr 20. Epub 2019 Apr 20.

School of Medicine, Southeast University, No.87, Dingjia Bridge, Nanjing, Jiangsu province, China.

Glucose metabolism reprogramming, which is a well-established characteristic of multiple cancers, demands a higher rate of glycolysis to meet the increasing demands for macromolecular synthesis and to maintain rapid proliferation in a hypoxic environment. However, the mechanism underlying this switch remains to be elucidated. In this study, we investigated the function of circular RNA MAT2B (circMAT2B) in hepatocellular carcinoma (HCC) glucose metabolism reprogramming and malignancy. Read More

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http://dx.doi.org/10.1002/hep.30671DOI Listing

Validation of electrical velocimetry in resuscitation of patients undergoing liver transplantation. Observational study.

J Clin Monit Comput 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Major hemodynamic changes are frequently noted during liver transplantation (LT). We evaluated the performance of electrical velocimetry (EV) as compared to that of TEE in SV optimization during liver transplantation. This was an observational study in 32 patients undergoing LT. Read More

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http://dx.doi.org/10.1007/s10877-019-00313-zDOI Listing

Yokenella regensburgei necrotizing fasciitis in an immunocompromised host.

J Infect Chemother 2019 Apr 16. Epub 2019 Apr 16.

Department of Public Health Services, 1800 Mt Vernon Ave, Kern County, Bakersfield CA, 93306, USA. Electronic address:

We report a case of necrotizing skin infection caused by Yokenella regensburgei in an immunosuppressed patient with orthotopic liver transplantation. Initial bacterial culture identification was suggestive of Hafnia alvei. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) confirmed identification of Y. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X193008
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http://dx.doi.org/10.1016/j.jiac.2019.03.025DOI Listing
April 2019
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Pharmacokinetics and Pharmacodynamics of Once-daily Prolonged-release Tacrolimus in Liver Transplant Recipients.

Clin Ther 2019 Apr 16. Epub 2019 Apr 16.

Département de Pharmacocinétique et Pharmacochimie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France; UMR8638 CNRS, UFR Pharmacie, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France. Electronic address:

Purpose: Limited published data are available regarding the pharmacokinetic (PK) and pharmacodynamic (PD) variables of prolonged-release tacrolimus (PRT) after liver transplantations. The goal of this study was to compare the PK and PD profiles of PRT in early and stable liver transplant recipients by developing a population PK model of PRT and investigating the profile of calcineurin activity (CNA) in the peripheral blood mononuclear cells.

Methods: A conversion from BID immediate-release tacrolimus (IRT) to once-daily PRT based on a one-to-one daily dose was performed at day 7 (D7) and D90 posttransplantation in groups A (n = 12) and B (n = 12), respectively. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.03.006DOI Listing

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Transplant Immunology, Department of Pathology & Laboratory Medicine & Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Functions of the GCN5-related N-acetyltransferase (GNAT) family of histone/protein acetyltransferases (HATs) in Foxp3+ T-regulatory (Treg) cells are unexplored, despite the general importance of these enzymes in cell biology. We now show that two prototypical GNAT family members, GCN5 (general control nonrepressed-protein 5, lysine acetyltransferase (KAT)2a) and p300/CBP-associated factor (p300/CBP-associated factor (PCAF), Kat2b) contribute to Treg functions through partially distinct and partially overlapping mechanisms. Deletion of Gcn5 or PCAF did not affect Treg development or suppressive function in vitro, but did affect inducible Treg (iTreg) development, and in vivo, abrogated Treg-dependent allograft survival. Read More

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http://dx.doi.org/10.3390/cancers11040554DOI Listing

Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases.

Pharmacol Rep 2019 Jan 11;71(3):385-392. Epub 2019 Jan 11.

Dept of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.

Background: Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases.

Methods: Meta-analysis was carried out to evaluate how donor/recipient CYP3A5 (n = 678) and recipient ABCB1 (n = 318) genotypes influence tacrolimus pharmacokinetics till one-month of transplantation.

Results: The donor CYP3A5*3/*3 genotype exhibited higher concentration/dose (C/D) ratio of tacrolimus in week 1 (mean difference: 65. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.006DOI Listing
January 2019

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.

Int Immunopharmacol 2019 Apr 16;72:224-234. Epub 2019 Apr 16.

Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address:

Fatty liver is used for transplantation due to organ shortage, but prone to cause complications like ischemia-reperfusion injury (IRI). NKT cells as a bridge between innate and adaptive immunity were reported to infiltrate the liver at the early phase of IRI induced in normal liver. However, the localization mechanism of NKT cells is not precise, and the role of NKT cells in fatty liver IRI is poorly understood. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.021DOI Listing

Normothermic Machine Perfusion in Liver Transplantation: Avoiding Recooling Before Engrafting Is Feasible and Promising.

Liver Transpl 2019 Apr 19. Epub 2019 Apr 19.

Abdominal Surgery and Organ Transplantation Unit, Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy.

It is well known that ischemia and the reperfusion process are distinct nonimmunological events that negatively impact graft outcome and induce delayed graft function, which are associated with high rates of organ failure, retransplantation, and death. Cooling the organ slows metabolism but does not prevent its progressive dysfunction and destruction of cellular integrity. On the other hand, in the reperfusion phase, the reactive oxygen metabolites cause leukocyte accumulation and therefore increased microvascular permeability and cellular injury. Read More

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http://dx.doi.org/10.1002/lt.25473DOI Listing