114,812 results match your criteria Liver Transplantation


EUS-GUIDED FINE-NEEDLE BIOPSY WITH OR WITHOUT RAPID ON-SITE EVALUATION FOR DIAGNOSIS OF SOLID PANCREATIC LESIONS: A RANDOMIZED CONTROLLED NON-INFERIORITY TRIAL.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.

Background And Aims: Benefit of rapid on-site evaluation (ROSE) on diagnostic accuracy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) has never been evaluated in a randomized study. This trial aimed to test the hypothesis that in solid pancreatic lesions (SPLs), diagnostic accuracy of EUS-FNB without ROSE was not inferior to that of EUS-FNB with ROSE.

Methods: Non-inferiority study (non-inferiority margin 5%) conducted at 14 centers in eight countries. Read More

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T Cell Exhaustion in Organ Transplantation.

Transplantation 2021 Jun 9. Epub 2021 Jun 9.

Division of Nephrology, Dialysis, Transplantation, Giannina Gaslini Children's Hospital, Genoa, Italy UO Nefrologia, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts Division of Nephrology, Massachusetts General Hospital, Harvard Medical School Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Exhaustion of T cells occurs in response to chronic exposure to self and foreign antigens. It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to clear chronic infections or eradicate tumors. T cell exhaustion is associated with a specific transcriptional, epigenetic, and metabolic program and characteristic cell surface markers' expression. Read More

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Postoperative incision scars and cosmetic satisfaction of living liver donors.

Medicine (Baltimore) 2021 Jun;100(23):e26187

Department of General Surgery, Changhua Christian Hospital, Changhua.

Abstract: Cosmetic appearance is a major concern for living donors. However, little is known about the impact of a surgical scar on body image changes in living liver donors. The aim of this study was to identify potential factors that cause displeasing upper midline incision scar, and to evaluate the overall satisfaction regarding body image and scarring after living donor hepatectomy. Read More

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Unexpected Hepatitis B Virus Transmission after Liver Transplant from NAT and Serology Negative Liver Donors who are Hepatitis C Viremic.

Hepatol Res 2021 Jun 11. Epub 2021 Jun 11.

MUH James D. Eason Transplant Institute, University of Tennessee Health Sciences Center 1265 Union Avenue, 4 Shorb Tower, Memphis, TN, 38104, USA.

The opioid epidemic has led to increased availability of organs for liver transplantation (LT). The success of direct-acting antiviral (DAA) therapy for Hepatitis C (HCV) has led to the acceptance of HCV viremic donor organs. Nucleic acid testing (NAT) has led to increased detection of HCV and Hepatitis B (HBV) in potential donors. Read More

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Lifestyle modifications for nonalcohol-related fatty liver disease: a network meta-analysis.

Cochrane Database Syst Rev 2021 Jun 11;6:CD013156. Epub 2021 Jun 11.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: The prevalence of nonalcohol-related fatty liver disease (NAFLD) varies between 19% and 33% in different populations. NAFLD decreases life expectancy and increases the risks of liver cirrhosis, hepatocellular carcinoma, and requirement for liver transplantation. There is uncertainty surrounding the relative benefits and harms of various lifestyle interventions for people with NAFLD. Read More

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Assessment of biventricular function in patients with hepatopulmonary syndrome.

Int J Cardiovasc Imaging 2021 Jun 10. Epub 2021 Jun 10.

Fourth Department of Internal Medicine, 'Hippokration' General Hospital, Medical School of Aristotle University of Thessaloniki, Thessaloníki, Greece.

Cardiac function impairment in the setting of hepatopulmonary syndrome (HPS) in patients with end stage liver disease remains an issue of debate. The current study evaluated possible correlations between HPS and biventricular systolic function in patients with decompensated cirrhosis. Consecutive liver transplantation candidates with stable decompensated cirrhosis were prospectively evaluated. Read More

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Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates.

Transplant Direct 2021 Mar 22;7(3):e677. Epub 2021 Feb 22.

Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Despite comprehensive multidisciplinary candidacy assessments to determine appropriateness for solid organ transplantation, limitations persist in identifying candidates at risk of adverse outcomes. Frailty measures may help inform candidacy evaluation. Our main objective was to create a solid organ transplant frailty index (FI), using the cumulative deficits model, from data routinely collected during candidacy assessments. Read More

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Transplant Hepatectomy With Portacaval Shunt and MARS Therapy for Perioperative Catastrophe: A Series of Four Liver Transplant Cases.

Transplant Direct 2021 Mar 18;7(3):e674. Epub 2021 Feb 18.

University of Maryland School of Medicine, Baltimore, MD.

Increased worldwide focus on maximal donor utilization and transplantation of patients once considered too ill to survive liver transplantation may increase the otherwise rare frequency of catastrophic graft failure. Although the deleterious effects of an acutely failing allograft have been established for decades, the optimal strategy in this patient population in the perioperative period remains ill-defined.

Methods: A retrospective review of all liver transplant recipients with perioperative failure leading to transplant hepatectomy between January 1, 2014 and June 30, 2017 was performed. Read More

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Solid Organ Transplantation During COVID-19 Pandemic: An International Web-based Survey on Resources' Allocation.

Transplant Direct 2021 Mar 11;7(3):e669. Epub 2021 Feb 11.

Department of Surgery, Oncology and Gastroenterology, Azienda Ospedaliera Universitaria, Padua, Italy.

Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.

Methods: SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Read More

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A Case of COVID-19 Re-Infection in a Liver Transplant Patient.

Cureus 2021 May 9;13(5):e14916. Epub 2021 May 9.

Emergency Medicine, Mayo Clinic, Jacksonville, USA.

Coronavirus disease 2019 (COVID-19) is an ongoing worldwide pandemic infection. The exact incidence of disease re-infection or recurrence remains unknown. One particular at-risk population includes individuals with solid organ transplantation on immunosuppression. Read More

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Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes.

Med Sci Monit 2021 Jun 11;27:e930258. Epub 2021 Jun 11.

Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin, China (mainland).

BACKGROUND To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. MATERIAL AND METHODS Twenty-four male rat DCD donor livers were randomly and averagely divided into normal, static cold storage (SCS), NMP, and NMP combined with BMMSCs groups. Liver function, bile secretion, and pathological features of DCD donor livers were detected to evaluate the protective effects of NMP and BMMSCs on DCD donor livers. Read More

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Sequential Organ Failure Assessment (SOFA) Score-Based Factors Predict Early Mortality in High-Risk Patients with Living Donor Liver Transplant.

Ann Transplant 2021 Jun 11;26:e931045. Epub 2021 Jun 11.

Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

BACKGROUND Patients with a Sequential Organ Failure Assessment (SOFA) score >7 on post-transplant day (POD) 7 have been reported to have a higher risk of short-term mortality after living donor liver transplant (LDLT). We sought to identify factors that were associated with early mortality in this high-risk population. MATERIAL AND METHODS A total of 102 patients with a high SOFA score (>7) on POD 7 were enrolled, of which 72 (70. Read More

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Acute kidney injury and chronic kidney disease after liver transplant: A retrospective observational study.

Nefrologia 2021 Jun 7. Epub 2021 Jun 7.

Division of Nephrology, Dialysis and Renal Transplantation, Maggiore Policlinico Hospital and Cà Granda IRCCS Foundation, Milano, Italy; University School of Medicine, Milano, Italy.

Background And Rationale: Chronic kidney disease remains an important risk factor for morbidity and mortality among LT recipients, but its exact incidence and risk factors are still unclear.

Material And Methods: We carried out a retrospective cohort study of consecutive adults who underwent liver transplant (January 2009-December 2018) and were followed (at least 6 months) at our institution. CKD was defined following the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guidelines. Read More

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Blocking siglec-10 tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma.

Exp Hematol Oncol 2021 Jun 10;10(1):36. Epub 2021 Jun 10.

Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: Tumor-associated macrophages (TAMs) promote key processes in the modulation of tumor microenvironment (TME). However, the clinical significance of heterogeneous subpopulations of TAMs in hepatocellular carcinoma (HCC) remains unknown.

Methods: HCC tissues from Zhongshan Hospital and data from The Cancer Genome Atlas were obtained and analyzed. Read More

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Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice.

Stem Cell Res Ther 2021 Jun 10;12(1):332. Epub 2021 Jun 10.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.

Complement factor H (FH) is the main plasma regulator of the alternative pathway of complement. Genetic and acquired abnormalities in FH cause uncontrolled complement activation amplifying, with the consequent accumulation of complement components on the renal glomeruli. This leads to conditions such as C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS). Read More

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Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection.

Orphanet J Rare Dis 2021 Jun 10;16(1):269. Epub 2021 Jun 10.

Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Purpose: We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transplantation (HSCT).

Methods: A retrospective analysis was performed on 35 patients with CAEBV at Beijing Children's Hospital from January 2016 to January 2020. The efficacy and adverse events of the L-DEP regimen were evaluated. Read More

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A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis.

BMC Cancer 2021 Jun 10;21(1):686. Epub 2021 Jun 10.

Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan Province, China.

Background: Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported to involve in multiple cancers including Hepatocellular Carcinoma (HCC). Our previous study found that HBx, HBV encodes X protein, mediated H3K4me3 modification in WDR5-dependent manner to involve in HBV infection and contribute to oncogene expression. Read More

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Why Are There So Many Liver Transplants from Living Donors In Asia And So Few In Europe And The US?

J Hepatol 2021 Jun 7. Epub 2021 Jun 7.

The Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharath Institute of Higher Education & Research, Chennai, India. Electronic address:

Acceptance of liver transplantation (LT) as an established treatment modality for end stage liver disease led an exponential increase in the demand for organs. This had a domino effect on the ever-increasing gap between availability of organs and the sick waiting for it. Interestingly, the west and the east influenced by cultural, socio-economic and other constraints attempted to address this problem of shortage in different ways. Read More

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Replacing centrifugation with mixing in urine analysis enriches protein pool in the urine samples.

Anal Biochem 2021 Jun 7:114284. Epub 2021 Jun 7.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Urine is the basic diagnostic material, easy to collect, not requiring invasive approach. During standard procedure the urine samples are centrifuged and the supernatant analysed physically, biochemically, and microscopically. The centrifugation step removes proteins including those forming aggregates especially in the state of illness and after transplantation. Read More

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Hypoxia-inducible exosomes facilitate liver-tropic pre-metastatic niche in colorectal cancer.

Hepatology 2021 Jun 10. Epub 2021 Jun 10.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.

Background & Aims: Liver metastasis is a frequent occurrences in patients with colorectal cancer (CRC), 15%-25% of CRC patients have liver metastases at the time of initial diagnosis (1). Specifically, some regional-stage patients with mild symptoms (stage Ⅰ or II) will also advance to liver metastases rapidly, even CRC lesion in situ is resected in time. Nevertheless, the precise mechanism of liver metastasis is still unclear. Read More

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Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation.

Int J Hematol 2021 Jun 10. Epub 2021 Jun 10.

Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Patients with hepatitis-associated aplastic anemia (HAA) who undergo living-donor liver transplantation (LDLT) have a poor prognosis with infections and bleeding complications. Rapid recovery of blood cells is critical for preventing these complications and improving the outcome. Immunosuppressive therapy (IST) combined with thrombopoietin receptor agonists is considered effective for aplastic anemia. Read More

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Percutaneous Transhepatic Single-Operator Cholangioscopy-Guided Intraductal Stone Therapy in a Liver Transplant Patient With Ischemic Cholangiopathy.

ACG Case Rep J 2021 Jun 7;8(6):e00595. Epub 2021 Jun 7.

Department of Gastroenterology and Hepatology, University of Wisconsin School of Medicine & Public Health, Madison, WI.

Ischemic cholangiopathy is a feared complication after liver transplantation. We present a 68-year-old man who is status postorthotopic liver transplant from a donation after cardiac death. His posttransplant course was complicated by the development of a biliary anastomotic stricture, ischemic cholangiopathy, biloma, recurrent cholangitis, and intrahepatic stones. Read More

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Continuous Normothermic Machine Perfusion for Renovation of Extended Criteria Donor Livers Without Recooling in Liver Transplantation: A Pilot Experience.

Front Surg 2021 24;8:638090. Epub 2021 May 24.

Organ Transplant Center, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Ischemia injury affects the recovery of liver allograft function. We propose a novel technique aimed at avoiding a second ischemic injury: transplanting an extended criteria donor (ECD) liver directly under normothermic machine perfusion (NMP) without recooling. We studied two cases to evaluate the efficacy and safety of this technique. Read More

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Emergent liver transplantation for patients with acute-on-chronic liver failure.

Authors:
Xiaofei Li

Dig Liver Dis 2021 Jun 6. Epub 2021 Jun 6.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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[A case report of splenorenal shunt embolization for treatment of refractory hepatic encephalopathy after liver transplantation].

Zhonghua Gan Zang Bing Za Zhi 2021 May;29(5):474-476

Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

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Portal vein obstruction after pediatric liver transplantation: A systematic review of current treatment strategies.

Transplant Rev (Orlando) 2021 May 29;35(4):100630. Epub 2021 May 29.

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Introduction: Portal vein obstruction (PVO) is a significant vascular complication after liver transplantation (LT) in pediatric patients. Current treatment strategies include percutaneous transluminal angioplasty (PTA), with or without stent placement, mesorex bypass (MRB), splenorenal shunt, mesocaval shunt, endovascular recanalization (EVR), splenic artery embolization and splenectomy. However, specific characteristics of patients undergoing intervention and selection of individual treatment and its efficacy have remained unclear. Read More

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Prognostic value of plasma IL-27 on biological viability of hepatic cystic echinococcosis patients.

Int J Infect Dis 2021 Jun 6. Epub 2021 Jun 6.

Department of Liver & Laparoscopic Surgery, Digestive & Vascular Surgery Center, 1(st)Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830054, China. Electronic address:

Objectives: We aimed to investigate the potential biomarker for distinguishing biological viability of hepatic echinococcosis.

Methods: We measured plasma concentrations of several cytokines and chemokines in patients with active and non-active cysts (HCE, n = 47), stable/progressive alveolar echinococcosis (HAE, n = 38) patients and their comparable infection-free volunteers (n = 48) through Luminex assay technique. Disease progression was staged according to the classification standard. Read More

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Anesthesia for the Patient with Severe Liver Failure.

Adv Anesth 2020 Dec;38:251-267

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

The incidence of liver failure continues to increase, and it is associated with increased perioperative morbidity and mortality. Liver failure is associated with multiorgan dysfunction, including central nervous, cardiac, respiratory, gastrointestinal, renal, and hematological systems. Preoperative identification, optimization, and tailored anesthetic management are essential for optimum outcomes in patients with liver disease undergoing surgery. Read More

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December 2020

Atrial reconstruction, distal gastrectomy with Ante-situm liver resection and autotransplantation for hepatocellular carcinoma with atrial tumor thrombus: A case report.

Medicine (Baltimore) 2021 May;100(19):e25780

Department of Liver Transplantation & Laparoscopic Surgery, Center of Organ Transplantation, The 1st Affiliated Hospital of Xinjiang Medical University.

Rationale: Hepatocellular with tumor thrombi extending into 3 hepatic veins (HVs) and right atrium presents as a real clinical challenge. We report the first documented case of surgical resection of an advanced hepatocellular carcinoma (HCC) with extensive invasion to distal stomach, atrium and hepatic vasculatures.

Patient Concerns: We present a case of 48-years old man with abdominal mass accompanying shortness of breath after activities. Read More

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