48,268 results match your criteria Liver Metastases


Characterization, prognosis, and treatment of patients with metastatic lung carcinoid tumors.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Service d'Oncologie Médicale, Groupement Hospitalier Centre, Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France; University of Lyon, Université Lyon 1, France. Electronic address:

Introduction: Metastatic lung carcinoids (MLC) remain poorly characterized and no prognostic stratification exists.

Methods: We conducted a retrospective study including patients with MLC in two European expert centers. The aims were to characterize these, identify prognostic factors of survival, and effectiveness of their treatments. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.002DOI Listing
February 2019

The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic stellate cells engenders an inflammatory microenvironment.

Exp Eye Res 2019 Feb 13. Epub 2019 Feb 13.

Inserm, Université de Rennes 1, UMR 1241, Nutrition, Métabolismes et Cancer (NuMeCan), Rennes, France; Département d'ophtalmologie, Faculté de Médecine, Université Laval, Québec, Canada; Centre Universitaire d'ophtalmologie-Recherche and Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, Canada; Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, Canada; Service d'ophtalmologie, CHU de Rennes, Rennes, France. Electronic address:

Uveal melanoma is the most common primary ocular neoplasm in adults. It is peculiar for its hematogenous dissemination and its high propensity to spread to the liver. Current treatments rarely prolong patient survival. Read More

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http://dx.doi.org/10.1016/j.exer.2019.02.012DOI Listing
February 2019

CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.

J Cancer Res Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.

Purpose: This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer.

Methods: We performed immunohistochemical staining for CD110 expression in tumor samples from 86 patients with pancreatic cancer. We evaluated clinical outcomes and other clinicopathological factors to determine the significance of CD110 on survival and liver metastasis. Read More

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http://dx.doi.org/10.1007/s00432-019-02860-zDOI Listing
February 2019

Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer-a retrospective observational study.

World J Surg Oncol 2019 Feb 15;17(1):33. Epub 2019 Feb 15.

Department of Surgery Fujita Health University, 1-98 Dengakugakubo Kutsukake-cho, Toyoake City, Aichi, 470-1192, Japan.

Background: Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. Read More

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http://dx.doi.org/10.1186/s12957-019-1575-yDOI Listing
February 2019

Progressive Oncological Surgery Is Associated with Increased Curative Resection Rates and Improved Survival in Metastatic Colorectal Cancer.

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Department of Surgery, Paracelsus Medical University, 5020 Salzburg, Austria.

Background: Secondary resection rates in first-line chemotherapy trials for metastatic colorectal cancer (mCRC) remain below 15%, representing a clear contrast to reports by specialised surgical centres, where progressive liver, peritoneal-surface, and pulmonary surgery increased access to curative-intent treatment. We present a long-term evaluation of oncosurgical management in a single-centre, analysing the aggregate effect of gradual implementation of surgical subspecialties and systemic treatments on mCRC patients' resection rates and prognosis.

Methods: Patients with newly diagnosed mCRC from 2003 to 2014 were retrospectively categorised into palliative treatment (PAT) and curative intent surgery (CIS) and three time periods were analysed for treatment changes and factors associated with survival. Read More

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http://dx.doi.org/10.3390/cancers11020218DOI Listing
February 2019

Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma.

Cancer Lett 2019 Feb 12. Epub 2019 Feb 12.

Liver Research Center, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with very limited treatment options. Antibody drug conjugates (ADCs) are promising cytotoxic agents capable of highly selective delivery. Aspartate-β-hydroxylase (ASPH) is a type II transmembrane protein highly expressed in PDACs (97. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.006DOI Listing
February 2019

Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation.

Int J Surg Pathol 2019 Feb 15:1066896919828111. Epub 2019 Feb 15.

1 Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

Carcinosarcoma of the upper urinary tract is very rare. In this article, we report a case of upper urinary tract carcinosarcoma with rhabdomyoblastic differentiation showing distinct transition between the epithelial and mesenchymal components confirmed by morphology and immunohistochemistry. An 81-year-old female underwent radical nephroureterectomy under the diagnosis of left ureteral urothelial carcinoma (UC). Read More

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http://dx.doi.org/10.1177/1066896919828111DOI Listing
February 2019

Safety of Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Liver Metastases from Ocular Melanoma Using the Delcath Systems' Second-Generation Hemofiltration System: A Prospective Non-randomized Phase II Trial.

Cardiovasc Intervent Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: To investigate the safety and toxicity of percutaneous hepatic perfusion with melphalan (M-PHP) with the Delcath Systems' second-generation (GEN 2) filter and compare the outcomes with historical data from studies using the first-generation filter.

Materials And Methods: A prospective, single-arm, single-center phase II study was carried out including 35 patients with unresectable, histologically confirmed liver metastases from ocular melanoma between February 2014 and June 2017. Main exclusion criteria were extrahepatic disease and age > 75 years. Read More

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http://dx.doi.org/10.1007/s00270-019-02177-xDOI Listing
February 2019

Unusual Sites of Metastatic and Benign I 131 Uptake in Patients with Differentiated Thyroid Carcinoma.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):740-750

Department of Nuclear Medicine and Molecular Imaging, Amrita Institute of Medical Sciences, Amrita Vishwavidyapeetham, Cochin, Kerala, India.

Introduction: Differentiated thyroid carcinoma (DTC) is the most common pathological type of thyroid carcinoma, which includes papillary and follicular subtypes. DTC is usually indolent, characterized by good prognosis, and long-term survival. Total thyroidectomy is the mainstay of treatment in DTC which is followed by diagnostic whole body 131I (WBI) scan. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_70_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330860PMC
February 2019
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Rare malignant glomus tumor of the stomach with liver metastases.

Radiol Case Rep 2019 Apr 2;14(4):463-467. Epub 2019 Feb 2.

Department of Diagnostic and Interventional Radiology, University Hospital Tor Vergata, Rome 00133, Italy.

We report a case of a 72-year-old male admitted in our Unit with anemia and a 10 cm liver neoplasm. Computed tomography scan showed 2 lesions respectively in the II, III and, VIII segment of the liver. Surgical resection of the larger liver mass was performed and the tumor appeared as a solid-cystic mass and a diagnosis of malignant mesenchymal tumor not otherwise specified, was made. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360248PMC

[A Case of Disease Control Achieved with TACE Using Cisplatin for Liver-Limited Metastases of Colorectal Cancer].

Gan To Kagaku Ryoho 2019 Jan;46(1):163-165

Dept. of Surgery, Kansai Rosai Hospital.

A 54-year-old woman with unresectable multiple liver-limited metastases of rectal cancer was treated with cisplatin-based transcatheter arterial chemoembolization(TACE). Before initiating TACE, we performed abdominoperineal resection for advanced rectal cancer, resection of the bilateral ovaries for metastasis, liver resection for metastasis, and oxaliplatin/irinote- can/anti-EGFR chemotherapy for the unresectable liver metastases. For the liver-limited metastases that did not respond to systemic chemotherapy, we successfully controlled the disease in 26 months with TACE every 4 or 5months. Read More

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January 2019

[A Case of Metachronous Metastasis to the Pancreas from Ascending Colon Cancer after Subtotal Stomach-Preserving Pancreaticoduodenectomy(SSPPD)].

Gan To Kagaku Ryoho 2019 Jan;46(1):136-138

Dept. of Surgery, Fuchu Hospital.

A67 -year-old man was diagnosed with ascending colon cancer and multiple liver metastases and underwent laparoscopic right hemicolectomy(D3 lymphadenectomy). Pathological examination indicated tubular adenocarcinoma(tub1, pT4apN2H2M1[HEP], pStage Ⅳ). After chemotherapy, he underwent hepatectomy. Read More

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January 2019

[A Case of Gastric Neuroendocrine Carcinoma with Bulky Lymph Node Metastases, Solitary Liver Metastasis, and Left Adrenal Metastasis Curatively Resected after Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):103-105

Dept. of Surgery, Osaka City Juso Hospital.

A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Read More

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January 2019

Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT.

HPB (Oxford) 2019 Feb 11. Epub 2019 Feb 11.

Department of Surgery and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: Associated liver partition and portal vein ligation in staged hepatectomy (ALPPS) is an alternative resection method to portal vein embolization (PVE) in patients with small future liver remnants (FLR) but has been associated with early tumor recurrences.

Methods: Twenty-four patients with colorectal liver metastases (CRLM) patients from the randomized multicenter LIGRO trial comparing outcome of ALPPS (n = 13) vs PVE (n = 11) were included in the study. Mutational analyses of the KRAS, NRAS, BRAF, PIC3CA and TP53 genes of the metastases were performed in 21 patients and correlated to early tumor recurrence. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.12.003DOI Listing
February 2019

Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition).

J Hematol Oncol 2019 Feb 14;12(1):16. Epub 2019 Feb 14.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China.

The lungs are the second most common site of metastasis for colorectal cancer (CRC) after the liver. Rectal cancer is associated with a higher incidence of lung metastases compared to colon cancer. In China, the proportion of rectal cancer cases is around 50%, much higher than that in Western countries (nearly 30%). Read More

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http://dx.doi.org/10.1186/s13045-019-0702-0DOI Listing
February 2019
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Dynamic prediction of repeated events data based on landmarking model: application to colorectal liver metastases data.

BMC Med Res Methodol 2019 Feb 14;19(1):31. Epub 2019 Feb 14.

Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: In some clinical situations, patients experience repeated events of the same type. Among these, cancer recurrences can result in terminal events such as death. Therefore, here we dynamically predicted the risks of repeated and terminal events given longitudinal histories observed before prediction time using dynamic pseudo-observations (DPOs) in a landmarking model. Read More

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http://dx.doi.org/10.1186/s12874-019-0677-0DOI Listing
February 2019

The great escape: How metastases of melanoma, and other carcinomas, avoid elimination.

Exp Biol Med (Maywood) 2018 Dec 6;243(17-18):1245-1255. Epub 2019 Jan 6.

6 Department of Surgery, Allegheny Health Network, Pittsburgh, PA 15224, USA.

Impact Statement: Cancers kill mainly because metastatic disease is resistant to systemic therapies. It was hoped that newer targeted and immunomodulatory interventions could overcome these issues. However, recent findings point to a generalized resistance to elimination imparted by both cancer-intrinsic and -extrinsic changes to provide survival advantages to the disseminated tumor cells. Read More

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http://dx.doi.org/10.1177/1535370218820287DOI Listing
December 2018

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.

PLoS One 2019 14;14(2):e0211916. Epub 2019 Feb 14.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Objectives: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211916PLOS
February 2019

Portal vein tumor thrombus from gastric cancer.

J Ultrason 2018 ;18(75):365-368

Pathology Department, Hospital Tuanku Ja'afar , Jalan Rasah, Negeri Sembilan , Malaysia.

A 53-year-old woman presented with left-sided abdominal pain, nausea and vomiting for the past 3 months with associated loss of appetite and weight. On physical examination, there was a large, ill-defined, firm mass at the epigastrium. Ultrasonography showed heterogeneously hypoechoic filling defect within the dilated main portal vein. Read More

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http://dx.doi.org/10.15557/JoU.2018.0054DOI Listing
January 2018

[Interstitial laser coagulation in the management of urothelial papillary carcinoma of the renal pelvis].

Urologiia 2018 Oct(4):122-126

Research Clinical Center of JSC RZD, Moscow, Russia.

This article presents a case of a 59-year-old patient with a primary tumor of the right kidney with bladder and liver metastases. The patient was treated in three-stages. In the first stage, he underwent ureteral stone extraction, laser resection of the tumor with subsequent vaporization. Read More

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October 2018

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.

Lab Anim 2019 Feb 13:23677219826165. Epub 2019 Feb 13.

2 Department of Molecular and Clinical Pharmacology, University of Liverpool, UK.

Improving outcomes in colorectal cancer requires more accurate in vivo modelling of the disease in humans, allowing more reliable pre-clinical assessment of potential therapies. Novel imaging techniques are necessary to improve the longitudinal assessment of disease burden in these models, reducing the number of animals required for translational studies. This report describes the development of an immune-competent syngeneic orthotopic murine model of colorectal cancer, utilising caecal implantation of CT26 cells stably transfected with the luciferase gene into immune-competent BALB/c mice, allowing serial bioluminescent imaging of cancer progression. Read More

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http://dx.doi.org/10.1177/0023677219826165DOI Listing
February 2019

A case of successfully resected metachronous gastric and gallbladder metastases from pancreatic body cancer.

Surg Case Rep 2019 Feb 13;5(1):21. Epub 2019 Feb 13.

Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) readily metastasizes to the lymph nodes, liver, lung, and peritoneum; however, gastric and gallbladder metastases are rare. We report a case of metachronous gastric and gallbladder metastases from PDAC.

Case Presentation: The patient is a 71-year-old man who underwent distal pancreatectomy for PDAC. Read More

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http://dx.doi.org/10.1186/s40792-019-0581-1DOI Listing
February 2019

[Influence of tumor-free resection margins on overall and disease-free survival after resection of colorectal liver metastases].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0899-zDOI Listing
February 2019

[Prognostic importance of resection margins in multiple colorectal liver metastases].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0864-xDOI Listing
February 2019

[Liver resection for colorectal metastases in elderly patients].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, 07747, Am Klinikum 1, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0847-yDOI Listing
February 2019

[Laparoscopic vs. open resection of colorectal liver metastases].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0879-3DOI Listing
February 2019

[Unresectable colorectal liver metastases : Prolonged survival with aggressive local therapy].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0854-zDOI Listing
February 2019

TOTAL OMENTECTOMY IN GASTRIC CANCER SURGERY: IS IT ALWAYS NECESSARY?

Arq Bras Cir Dig 2019 Feb 7;32(1):e1425. Epub 2019 Feb 7.

Discipline of Digestive Surgery, Department of Gastroenterology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.

Background: Traditionally, total omentectomy is performed along with gastric resection and extended lymphadenectomy in gastric cancer (GC) surgery. However, solid evidences regarding its oncologic benefit is still scarce.

Aim: To evaluate the incidence of metastatic omental lymph nodes (LN) in patients undergoing curative gastrectomy for GC, as well as its risk factors and patients' outcomes. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1425DOI Listing
February 2019

Breast Cancer with Paraneoplastic Syndrome in a 72 Year Old Male Patient.

Mymensingh Med J 2019 Jan;28(1):254-258

Dr Sabrina Yesmin, Associate Professor and Head, Department of Medicine, Dr Sirajul Islam Medical College Hospital, Dhaka, Bangladesh; E-mail:

Breast cancer in male is rare which accounts about 1% of all malignant breast neoplasm cases. Since paraneoplastic syndrome is unusual with male breast cancer, very few reported cases are found. A72- year-old gentleman presented with proximal myopathy in all four limbs was referred to Dr. Read More

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January 2019

Association between Anaesthetic Technique and Oncological Outcomes after Colorectal Carcinoma Liver Metastasis Resection.

Int J Med Sci 2019 24;16(2):337-342. Epub 2019 Jan 24.

Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, 225 Changhai Road, Shanghai, China.

Recently published studies suggest that the anaesthetic technique used during oncologic surgery can improve patient outcomes. Therefore, the authors evaluated the survival of patients with resected colorectal carcinoma liver metastases (CRCLMs) who received either EGA (general anaesthesia [GA] combined with epidural anaesthesia [EA]) or GA alone. We conducted an ambispective cohort study including 225 post-surgical CRCLM patients between May 2007 and July 2012 and performed a follow-up investigation of survival in July 2017. Read More

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http://dx.doi.org/10.7150/ijms.28016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367527PMC
January 2019

Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the Stroma.

Int J Gynecol Pathol 2019 Feb 7. Epub 2019 Feb 7.

Departments of Obstetrics and Gynaecology (M.C.V., E.H.) Pathology, Elisabeth-Tweesteden Hospital (E.H., A.A.M.v.d.W.), LC Tilburg Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre (S.C.H.A.v.d.S., T.H.V.K.) Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre (S.C.H.A.v.d.S., L.F.A.G.M.), HB Nijmegen, The Netherlands.

Lymphogenic and hematogenic metastases are uncommon in ovarian cancer, especially at presentation. We hypothesized that MMP-14 and MMP-2, CD44, and highly sulfated chondroitin sulfate (CS-E) may be overexpressed in tumors with these metastatic patterns. These molecules are all present in the ovarian tumor microenvironment, wherein they may interact. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000587DOI Listing
February 2019
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Surgical Management of Solid Pseudopapillary Tumor of the Pancreas.

JSLS 2018 Oct-Dec;22(4)

Division of Gastrointestinal Surgery of the Hospital Nossa Senhora das Graças and Clinical Hospital of the Federal University of Parana, Curitiba, Brazil.

Background And Objectives: Although solid pseudopapillary tumor (SPT) of the pancreas is rare, its diagnosis has increased severalfold in the past decades. We present our experience in the management of SPT, including a patient who experienced tumor rupture during laparoscopy pancreatic resection.

Methods: Data on all patients with SPT who were subjected to surgical treatment were retrospectively obtained. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365096PMC
February 2019

Prognostic significance of doubling time in patients undergoing radical surgery for metachronous peritoneal metastases of colorectal cancer.

Int J Colorectal Dis 2019 Feb 9. Epub 2019 Feb 9.

Department of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: The doubling times of tumor volume and tumor markers are associated with the prognosis of liver or lung metastases from colorectal cancer (CRC). However, no studies have assessed peritoneal metastases. Therefore, we aimed to elucidate the association between doubling time and the prognosis of patients who underwent radical surgery for metachronous peritoneal metastases of CRC. Read More

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http://dx.doi.org/10.1007/s00384-019-03259-5DOI Listing
February 2019
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Detection of distant metastatic disease by positron emission tomography with F-fluorodeoxyglucose (FDG-PET) at initial staging of cervical carcinoma.

Int J Gynecol Cancer 2019 Feb 9. Epub 2019 Feb 9.

Department of Radiation Oncology, Washington University in Saint Louis, St Louis, Missouri, USA

Objective: The detection of distant metastatic disease in cervical cancer patients at diagnosis is critical in accurate prognostication and directing treatment strategies. This study describes the frequency and sites of distant metastatic disease at diagnosis in patients with cervical cancer as detected by positron emission tomography with F-fluorodeoxyglucose (FDG-PET).

Methods: Patients with newly diagnosed cervical cancer underwent pre-treatment whole-body FDG-PET starting in 1997 at an academic institution. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000108DOI Listing
February 2019
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Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Feb 6. Epub 2019 Feb 6.

University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Abiraterone acetate plus prednisone or prednisolone improves progression-free survival and overall survival in patients with metastatic castration-resistant prostate cancer. Radium-223 improves overall survival and delays the onset of symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases. We assessed concurrent treatment with abiraterone acetate plus prednisone or prednisolone and radium-223 in such patients. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30860-XDOI Listing
February 2019
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Metastatic Profile of Colorectal Cancer: Interplay Between Primary Tumor Location and KRAS Status.

J Surg Res 2019 Feb 5. Epub 2019 Feb 5.

Division of Surgical Oncology, National Cancer Centre, Singapore. Electronic address:

Background: Mutant KRAS tumors are purported to metastasize differently than wild-type KRAS tumors. The biological heterogeneity of tumors from different parts of the colon are also reported to affect metastasis. This study aims to characterize the metastatic profile by evaluating these factors in unison. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.025DOI Listing
February 2019
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Mixed response to osimertinib and the beneficial effects of additional local therapy.

Thorac Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Background: Although non-small cell lung cancers (NSCLCs) harboring EGFR mutations initially respond well to EGFR-tyrosine kinase inhibitors (TKIs), they typically progress after approximately one year. The EGFR T790M mutation is the most common resistance mechanism. NSCLCs with T790M respond well to osimertinib; however, the heterogeneity of NSCLCs may limit the efficacy. Read More

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http://doi.wiley.com/10.1111/1759-7714.12991
Publisher Site
http://dx.doi.org/10.1111/1759-7714.12991DOI Listing
February 2019
5 Reads

Understanding key symptoms, side effects, and impacts of HR+/HER2- advanced breast cancer: qualitative study findings.

J Patient Rep Outcomes 2019 Feb 7;3(1):10. Epub 2019 Feb 7.

Northwestern University Feinberg School of Medicine, 633 N. Saint Clair St., 19th Floor, Chicago, IL, 60611, USA.

Background: Patients with breast cancer experience a variety of disease symptoms and treatment-related side effects that can adversely affect functioning. The breast cancer experience may differ across disease stages and biomarker subtypes. This study identified relevant disease symptoms, treatment-related side effects, and physical functioning impacts in women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer. Read More

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http://dx.doi.org/10.1186/s41687-019-0098-1DOI Listing
February 2019

Clinical Predictive Factors for the Efficacy of Everolimus in Patients With Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer: A Multicenter Retrospective Cohort Study in Japan.

Breast Cancer (Auckl) 2019 22;13:1178223418825135. Epub 2019 Jan 22.

Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Purpose: To investigate the clinical predictive factors for the efficacy of everolimus (EVE) for advanced/metastatic breast cancer (AMBC).

Methods: Routine practice data of consecutive patients with AMBC who received EVE at 5 institutions in western Japan were retrospectively analyzed in this cohort study (study registration no.: UMIN 000032569). Read More

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http://dx.doi.org/10.1177/1178223418825135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343452PMC
January 2019
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Biomarker concordance between primary colorectal cancer and its metastases.

EBioMedicine 2019 Feb 4. Epub 2019 Feb 4.

Colorectal & Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Science, Faculty of Biology, Medicine and Health, University of Manchester, UK. Electronic address:

Background: The use of biomarkers to target anti-EGFR treatments for metastatic colorectal cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic biopsies. We aim to review concordance between primary CRC and its metastatic sites.

Methods: A systematic review and meta-analysis of all published studies (1991-2018) reporting on biomarker concordance between primary CRC and its metastatic site(s) was undertaken according to PRISMA guidelines using several medical databases. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.01.050DOI Listing
February 2019
2 Reads

Radioembolisation with 90Y microspheres for neuroendocrine liver metastases: an institutional case series, systematic review and meta-analysis.

HPB (Oxford) 2019 Feb 4. Epub 2019 Feb 4.

Department of Imaging, Imperial College London, Hammersmith Hospital, London, W12 0HS, United Kingdom.

Background: Neuroendocrine liver metastases are clinically challenging due to their frequent disseminated distribution. This study aims to present a British experience with an emerging modality, radioembolisation with yttrium-90 labelled microspheres, and embed this within a meta-analysis of response and survival outcomes.

Methods: A retrospective case series of patients treated with SIR-Spheres (radiolabelled resin microspheres) was performed. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.12.014DOI Listing
February 2019

Clinical outcomes of advanced stage cancer patients treated with sequential immunotherapy in phase 1 clinical trials.

Invest New Drugs 2019 Feb 6. Epub 2019 Feb 6.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.

Background Given the increasing number of available immunotherapeutic agents, more patients are presenting after failing immunotherapy in need of new treatment options. In this study, we investigated the clinical outcomes of patients treated with sequential immunotherapy. Methods We performed a retrospective review of 90 advanced stage cancer patients treated on immunotherapy-based phase 1 clinical trials at Winship Cancer Institute from 2009 to 2017. Read More

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http://dx.doi.org/10.1007/s10637-019-00736-0DOI Listing
February 2019

Initial experience with irreversible electroporation of liver tumours.

Eur J Radiol Open 2019 22;6:62-67. Epub 2019 Jan 22.

Division of Surgery, Department of Clinical Sciences, Karolinska Inst itutet at Danderyd Hospital, 182 88 Stockholm, Sweden.

Introduction: Thermal ablation of liver tumours is an established technique used in selected patients with relatively small tumours that can be ablated with margin. Thermal ablation methods are not advisable near larger bile ducts that are sensitive to thermal injury causing strictures and severe morbidity. Irreversible electroporation (IRE) has the possibility to treat these tumours without harming the bile tree. Read More

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http://dx.doi.org/10.1016/j.ejro.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351588PMC
January 2019
1 Read

Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma.

Oncoimmunology 2019 10;8(3):1550342. Epub 2019 Jan 10.

EA4340 BCOH, Versailles University, Paris-Saclay University, Boulogne, France.

Radiofrequency ablation (RFA) of colorectal liver metastases activates a specific T-cell response that is ineffective in avoiding recurrence. Recently, local immunomodulation garnered interests as a way to improve the immune response. We were interested in improving the RFA immune response priming to propose a curative treatment of colorectal cancer (CRC) based on antitumor immunity. Read More

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1550342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350685PMC
January 2019
1 Read

The Management of Colorectal Cancer Liver Metastases: The Radiation Oncology Viewpoint.

Int J Radiat Oncol Biol Phys 2019 Mar;103(3):540-541

Radiation Medicine Program, Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2018.10.010DOI Listing
March 2019
1 Read

Incidence, patterns and prognosis of first distant recurrence after surgically treated early stage endometrial cancer: Results from the multicentre FRANCOGYN study group.

Eur J Surg Oncol 2019 Jan 19. Epub 2019 Jan 19.

Department of Gynecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University, Paris, France; INSERM UMR S 938, Université Pierre et Marie Curie, Paris, France.

Patterns of distant metastatic failure of endometrial cancer (EC) by specific anatomic site are not well described in the literature. In this manuscript, we evaluated the metastatic patterns of EC cancer and analysed the potential distribution of metastatic disease in this malignancy.

Methods: A total of 1444 women with EC were identified. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.011DOI Listing
January 2019
2 Reads

TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ.

Oncol Rep 2019 Jan 30. Epub 2019 Jan 30.

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China.

Pancreatic cancer (PC), a malignancy of the digestive system, has one of the highest rates of metastasis and mortality. It is characterized by the detachment, migration, implantation and infiltration of tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), a novel member of the TSPAN superfamily, is highly expressed in many types of cancer, including gastric, colon, liver and esophageal cancer. Read More

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http://dx.doi.org/10.3892/or.2019.6989DOI Listing
January 2019
1 Read

Prognostic Significance of Young Age and Non-Bone Metastasis at Diagnosis in Patients with Metastatic Prostate Cancer: a SEER Population-Based Data Analysis.

J Cancer 2019 1;10(3):556-567. Epub 2019 Jan 1.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, P.R. China.

This study compared the clinicopathological features and survival of metastatic prostate cancer (mPCa) after stratification by age and non-bone-related metastasis to identify prognostic factors. Patients with mPCa between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database and analyzed. The overall survival (OS) rate was assessed using the Kaplan-Meier curve and log-rank test as well as multivariate Cox regression analysis. Read More

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http://dx.doi.org/10.7150/jca.29481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360431PMC
January 2019
1 Read
2.639 Impact Factor