51,776 results match your criteria Liver Metastases


Impact of extent of disease on 1-year healthcare costs in patients who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: retrospective observational cohort study.

BJS Open 2020 Jul 11. Epub 2020 Jul 11.

Departments of Surgery, Division of Surgical Oncology, Groningen, the Netherlands.

Background: The goal of this retrospective observational study was to determine the impact of the extent of peritoneal disease on 1-year healthcare costs in patients with colorectal peritoneal metastases (PM) who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). The extent of peritoneal disease, expressed by the Peritoneal Cancer Index (PCI), directly affects the complexity of CRS + HIPEC and ultimately survival outcomes. The impact of the PCI on treatment-related healthcare costs remains unknown. Read More

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http://dx.doi.org/10.1002/bjs5.50320DOI Listing

Prognostic impact of primary tumor location in Stage III colorectal cancer-right-sided colon versus left-sided colon versus rectum: a nationwide multicenter retrospective study.

J Gastroenterol 2020 Jul 10. Epub 2020 Jul 10.

Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 1040045, Japan.

Background: Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. Read More

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http://dx.doi.org/10.1007/s00535-020-01706-7DOI Listing

An Odyssey into the Land of Deleterious Rare Mutations in Colorectal Liver Metastases.

Ann Surg Oncol 2020 Jul 10. Epub 2020 Jul 10.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-020-08820-zDOI Listing

Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.

Clin Colorectal Cancer 2020 Jan 30. Epub 2020 Jan 30.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background: The value of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneally metastasized goblet-cell carcinoids (GCCs) and mixed adenoneuroendocrine carcinomas (MANECs) is currently unclear. We compared outcomes of CRS-HIPEC to surgery alone for peritoneally metastasized GCCs and MANECs.

Patients And Methods: Two cohorts were obtained from the Netherlands Cancer Registry (n = 569): patients with peritoneally metastasized GCCs and MANECs treated with CRS-HIPEC in Dutch and Belgian centers (n = 45), and patients treated with surgery alone. Read More

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http://dx.doi.org/10.1016/j.clcc.2020.01.002DOI Listing
January 2020

Response to Comment on "Extended Molecular Profiling Improves Stratification and Prediction of Survival After Resection of Colorectal Liver Metastases".

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of General, Visceral and Transplantation Surgery, Universitätsmedizin Mainz Mainz, Germany Department of Pathology, Universitätsmedizin Mainz Mainz, Germany Department of Gastroenterology and Hepatology, Universitätsmedizin Mainz, Mainz, Germany Department of Pathology, Universita[Combining Diaeresis]tsmedizin Mainz, Mainz, Germany Department of General, Visceral and Transplantation Surgery, Universita[Combining Diaeresis]tsmedizin Mainz Mainz, Germany.

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http://dx.doi.org/10.1097/SLA.0000000000004097DOI Listing

Pattern and prognosis of distant metastases in nasopharyngeal carcinoma: A large-population retrospective analysis.

Cancer Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Radiation Oncology, the First Hospital of China Medical University, Shenyang, Liaoning, China.

Currently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. Thus, the main purpose of our study was to investigate the metastasis patterns of different histological types of NPC and to clarify the prognostic characteristics of metastases at different sites. Patients were enrolled from the SEER program from 2010 to 2016. Read More

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http://dx.doi.org/10.1002/cam4.3301DOI Listing

Metastases of soft tissue sarcoma to the liver: A Historical Cohort Study from a Hospital-based Cancer Registry.

Cancer Med 2020 Jul 10. Epub 2020 Jul 10.

Sarcoma Center, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan.

Background: Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type.

Methods: From a Hospital-based Cancer Registry, 658 patients registered between 2007 and 2017 with soft tissue sarcomas were evaluated. Read More

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http://dx.doi.org/10.1002/cam4.3304DOI Listing

Durable complete response after afatinib and crizotinib in an advanced non-small cell lung cancer patient with EGFR L861Q mutation and acquired MET amplification: a case report.

Ann Palliat Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, Chengdu, China.

Epidermal growth factor receptor (EGFR) L861Q mutation is a non-classical mutation, with a low incidence, poor response, and uncertain resistance mechanisms when treated by an EGFR tyrosine kinase inhibitor (EGFR-TKI). The liver is one of the most common distant organs to metastasize in nonsmall cell lung cancer (NSCLC), and achieving complete remission treatment for the liver is difficult. In this report, a patient was diagnosed with advanced lung adenocarcinoma harboring the EGFR L861Q mutation and responded well to afatinib for 16 months. Read More

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http://dx.doi.org/10.21037/apm-19-482DOI Listing

Large surgically resected leiomyosarcoma of the liver: a case report.

Surg Case Rep 2020 Jul 9;6(1):168. Epub 2020 Jul 9.

Department of Surgery, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, 1-9-6 Senda-machi, Naka-ku, Hiroshima 730-8619, Japan.

Background: Primary hepatic leiomyosarcoma (PHL) is an extremely rare type of tumor. We herein report a case of a large surgically resected leiomyosarcoma of the liver.

Case Presentation: A 69-year-old man with a feeling of epigastric compression was referred for examination of an abdominal mass. Read More

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http://dx.doi.org/10.1186/s40792-020-00934-6DOI Listing

Recurrence After Liver Resection of Colorectal Liver Metastases: Repeat Resection or Ablation Followed by Hepatic Arterial Infusion Pump Chemotherapy.

Ann Surg Oncol 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

Background: The aim of this study was to investigate the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases (CRLM).

Methods: A retrospective cohort study was conducted of patients from two centers who were treated with resection and/or ablation of recurrent CRLM only between 1992 and 2018. Overall survival (OS) and hepatic disease-free survival (hDFS) were estimated using the Kaplan-Meier method. Read More

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http://dx.doi.org/10.1245/s10434-020-08776-0DOI Listing

Fibrosis-4 Index, a Noninvasive Fibrosis Marker, Predicts Survival Outcomes After Hepatectomy for Colorectal Cancer Liver Metastases.

Ann Surg Oncol 2020 Jul 9. Epub 2020 Jul 9.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: Liver fibrosis influences liver regeneration and surgical outcomes, and several noninvasive models based on laboratory data have been developed to predict liver fibrosis. This study was performed to determine whether the Fibrosis-4 (FIB-4) index, a noninvasive fibrosis marker, can predict the prognosis in patients with colorectal liver metastases (CRLM) undergoing hepatectomy.

Methods: This retrospective study involved 193 consecutive patients with CRLM who underwent hepatectomy. Read More

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http://dx.doi.org/10.1245/s10434-020-08828-5DOI Listing

Carotid Space Masses With Liver and Bone Metastases.

JAMA Otolaryngol Head Neck Surg 2020 Jul 9. Epub 2020 Jul 9.

Neuroradiology Section, Department of Radiology, Mayo Clinic Arizona, Phoenix, Arizona.

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http://dx.doi.org/10.1001/jamaoto.2020.1107DOI Listing

Diabetic mortality risk among cancer patients in the United State SEER population, 1975-2016.

Endocrine 2020 Jul 8. Epub 2020 Jul 8.

Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, PR China.

Background: The focus on diabetic mortality in cancer patients remains superficial. The objective of our study is to identify cancer patients with the highest risk of diabetic mortality compared with other cancer patients and the general US population.

Methods: The representative data of cancer patients dying from diabetes between 1975 and 2016 was retrieved from the Surveillance, Epidemiology, and End Results program. Read More

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http://dx.doi.org/10.1007/s12020-020-02405-2DOI Listing

ASO Author Reflections: The Moment That BRAF V600E Mutation Starts Evolving into "Precision Oncosurgery" in Colorectal Liver Metastases.

Ann Surg Oncol 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1245/s10434-020-08818-7DOI Listing

Efficacy of eribulin for metastatic breast cancer based on localization of specific secondary metastases: a post hoc analysis.

Sci Rep 2020 Jul 8;10(1):11203. Epub 2020 Jul 8.

Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Prior pooled analysis of eribulin studies (301 and 305) indicated eribulin prolonged overall survival (OS) in patients with locally advanced/metastatic breast cancer (MBC) regardless of visceral or nonvisceral disease. This hypothesis-generating post hoc analysis examined the efficacy of eribulin according to the location of metastatic sites at baseline in 1864 pretreated patients with locally advanced/MBC from studies 301 and 305. Analyses included OS, progression-free survival (PFS), and objective response rate; OS and PFS were also analyzed according to estrogen-receptor status. Read More

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http://dx.doi.org/10.1038/s41598-020-66980-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343788PMC

The impact of tranexamic acid on administration of red blood cell transfusions for resection of colorectal liver metastases.

HPB (Oxford) 2020 Jul 5. Epub 2020 Jul 5.

Sunnybrook Research Institute Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada; Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address:

Background: Red blood cell transfusions (RBCT) remain a concern for patients undergoing hepatectomy. The effect of tranexamic acid (TXA), an anti-fibrinolytic, on receipt of RBCT in colorectal liver metastases (CRLM) resection was examined.

Methods: Hepatectomies for CRLM over 2009-2014 were included. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.06.004DOI Listing

Recurrence Patterns for Pancreatic Ductal Adenocarcinoma after Upfront Resection Versus Resection Following Neoadjuvant Therapy: A Comprehensive Meta-Analysis.

J Clin Med 2020 Jul 6;9(7). Epub 2020 Jul 6.

Department of Hepatobiliary, Pancreatic and Transplant Surgery, Freeman Hospital, Newcastle upon Tyne NE7 7DN, Tyne and Wear, UK.

Background: Neoadjuvant therapy (NAT) represents a paradigm shift in the management of patients with pancreatic ductal adenocarcinoma (PDAC) with perceived benefits including a higher R0 rate. However, it is unclear whether NAT affects the sites and patterns of recurrence after surgery. This review seeks to compare sites and patterns of recurrence after resection between patients undergoing upfront surgery (US) or after NAT. Read More

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http://dx.doi.org/10.3390/jcm9072132DOI Listing

Multicenter Cohort Study to Assess the Association between Changes on Imaging and Outcome after Regorafenib Treatment (KSCC1603).

Oncology 2020 Jul 8:1-8. Epub 2020 Jul 8.

National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Background: Molecular targeted drugs having angiogenesis-inhibiting properties allow the induction of necrosis inside tumors. We retrospectively investigated the relationship between changes on imaging associated with regorafenib (REGO) and treatment outcomes using real-world data.

Patients And Methods: The eligibility criteria included an ECOG PS of 0-1, a starting dose of 120 or 160 mg/day of REGO, and a duration of treatment of at least 35 days. Read More

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http://dx.doi.org/10.1159/000507814DOI Listing

Letter to the Editor: First Report of Living Donor Liver Transplantation for Imatinib-Resistant GIST Liver Metastases. A new therapeutic option in Transplant Oncology.

Liver Transpl 2020 Jul 8. Epub 2020 Jul 8.

Medical Oncology Unit, S.Orsola-Malpighi University Hospital, Bologna, Italy.

We read with great interest the article "First Report of Living Donor Liver Transplantation for Imatinib-Resistant GIST Liver Metastases. A new therapeutic option in Transplant Oncology , which describes a case of a gastric KIT/PDGFRA WT GIST with liver metastates in a young woman who underwent living donor LT. The approach of LT in GIST is extremely interestingly, but requires a big attention and caution on the message given to the scientific community and to patients. Read More

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http://dx.doi.org/10.1002/lt.25844DOI Listing

Chemorefractory liver metastasis from cervical cancer successfully treated with a combination of yttrium-90 and immunotherapy.

Radiol Case Rep 2020 Aug 26;15(8):1359-1365. Epub 2020 Jun 26.

Department of Radiology, Section of Vascular and Interventional Radiology, University of Missouri, One Hospital drive, Columbia, MO 65212, USA.

Liver metastases in cervical cancer is rare and can be difficult-to-treat. The current guidelines established by the Gynecologic Oncology Group recommend platinum-based systemic chemotherapy in combination with an anti-angiogenic agent such as bevacizumab, however, overall survival remains poor following diagnosis and options for patients who fail chemotherapy are limited. Yttrium-90 (Y90) radioembolization (RE) has shown great promise in the treatment of chemo-refractory colorectal liver metastases. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327429PMC

Surgical and local treatment of hepatic metastasis in pancreatic ductal adenocarcinoma: recent advances and future prospects.

Ther Adv Med Oncol 2020 23;12:1758835920933034. Epub 2020 Jun 23.

Department of General Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with increasing incidence and mortality. More than half of PDAC patients develop metastases, with the liver being the most common site. Patients with pancreatic ductal adenocarcinoma with liver metastases (PCLM) have a very limited scope for surgery due to aggressive tumor behavior and poor prognosis. Read More

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http://dx.doi.org/10.1177/1758835920933034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313332PMC

Durable Response and Good Tolerance to the Triple Combination of Toripalimab, Gemcitabine, and Nab-Paclitaxel in a Patient With Metastatic Pancreatic Ductal Adenocarcinoma.

Front Immunol 2020 19;11:1127. Epub 2020 Jun 19.

Department of Abdominal Oncology, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

The performance of immune checkpoint inhibitor (ICI) monotherapy was proved to be disappointing in pancreatic ductal adenocarcinoma (PDAC). Increasing evidence has shown the promising efficacy of ICIs combined with systemic therapy in the first-line treatment in solid tumors. We reported a case of a metastatic PDAC patient who had a long-term partial response and good tolerance to the combined approach of toripalimab (a novel PD-1 inhibitor) and gemcitabine plus nab-paclitaxel (GA). Read More

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http://dx.doi.org/10.3389/fimmu.2020.01127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318868PMC

Comparative Treatment Patterns and Outcomes of Fulvestrant versus Everolimus Plus Exemestane for Postmenopausal Metastatic Breast Cancer Resistant to Aromatase Inhibitors in Real-World Experience.

Ther Clin Risk Manag 2020 30;16:607-615. Epub 2020 Jun 30.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Background: Fulvestrant (FUL) and the combination of everolimus and exemestane (EVE-EXE) were the options to treat hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) patients who were refractory to aromatase inhibitors (AIs). The practical knowledge of treatment patterns and outcomes between the two regimens is essential for improving treatment decisions.

Methods: HR+/HER2- MBC patients, who were refractory to AI, were treated with FUL or EVE-EXE from June 2013 to June 2016 were included. Read More

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http://dx.doi.org/10.2147/TCRM.S255365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335268PMC

Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group.

Cancers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, location VUmc, 1081 HV Amsterdam, The Netherlands.

The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a 'toolbox' of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability and ablatability criteria for the treatment of colorectal liver metastases (CRLM). To pursue consensus, members of the multidisciplinary COLLISION and COLDFIRE trial expert panel employed the RAND appropriateness method (RAM). Read More

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http://dx.doi.org/10.3390/cancers12071779DOI Listing

Survival outcome of palliative primary tumor resection for colorectal cancer patients with synchronous liver and/or lung metastases: A retrospective cohort study in the SEER database by propensity score matching analysis.

Int J Surg 2020 Jul 4. Epub 2020 Jul 4.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China; Medical College of Shantou University, Shantou, Guangdong, 515000, China; School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China. Electronic address:

Background: There is a great matter of controversies whether some of these synchronous metastatic colorectal cancer patients can benefit from palliative primary tumor resection (pPTR) and there is still no reported randomized control trial to address this issue.

Methods: Patients with microscopically proven metastatic colorectal cancer were identified within the SEER database (2010 to 2016). Patients were propensity matched 1:1 into pPTR and non-surgery groups and among the matched cohort, the univariable and multivariable Cox proportional hazards regression models were performed to identify predictors of survival. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.024DOI Listing

The Landmark Series: Neuroendocrine Tumor Liver Metastases.

Ann Surg Oncol 2020 Jul 6. Epub 2020 Jul 6.

Surgical Oncology and Endocrine Surgery, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, 4644 JCP, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

Background: Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver.

Methods: In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as several randomized control trials which have investigated strategies for systemic control of metastatic disease.

Results: Liver-directed surgical approaches and locally ablative procedures are recommended for patients with limited, resectable, and in some cases, nonresectable tumor burden. Read More

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http://dx.doi.org/10.1245/s10434-020-08787-xDOI Listing

Younger Age Is Associated with Improved Survival in Patients Undergoing Liver Transplantation Alone for Metastatic Neuroendocrine Tumors.

J Gastrointest Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.

Background: Neuroendocrine tumor (NET) metastases are a major cause of morbidity and mortality. The role of liver transplantation to treat unresectable metastases from NET is controversial.

Methods: We evaluated outcomes of all patients undergoing "isolated" liver transplantation (LT) for metastatic NETs in the USA, from October 1988 through June 2018 using the UNOS dataset. Read More

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http://dx.doi.org/10.1007/s11605-020-04708-1DOI Listing

Associated liver partition and portal vein ligation for staged hepatectomy: a review.

Transl Gastroenterol Hepatol 2020 5;5:37. Epub 2020 Jul 5.

Department of General Surgery, Tan Tock Seng Hospital, Singapore.

Outcomes of liver resection have improved with advances in surgical techniques, improvements in critical care and expansion of resectability criteria. However, morbidity and mortality following liver resection continue to plague surgeons. Post-hepatectomy liver failure (PHLF) due to inadequate future liver remnant (FLR) is an important cause of morbidity and mortality following liver resection. Read More

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http://dx.doi.org/10.21037/tgh.2019.12.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063517PMC

Liver Metastases-directed Therapy in the Management of Oligometastatic Breast Cancer.

Clin Breast Cancer 2020 May 13. Epub 2020 May 13.

Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano (Milano), Italy.

Introduction: In the context of metastatic breast cancer, dissemination to the liver is a frequent occurrence. We aimed to evaluate the outcome and toxicity of metastatic breast cancer with liver oligometastases treated with metastases-directed therapies (MDTs), including surgery, stereotactic body radiation therapy, or thermal ablation (radiofrequency or microwaves).

Patients And Methods: We included patients with diagnosis of 1 to 5 liver metastases. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.05.006DOI Listing

A forehead hematoma as the initial clinical sign of lung cancer.

Arch Craniofac Surg 2020 Jun 29;21(3):198-201. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Primary lung cancer commonly metastasizes to the brain, bones, liver, and adrenal glands. In some cases, bone metastasis serves as the first presenting sign of lung cancer with bone pain and headache, but it is not common. The incidence of skull metastasis in lung squamous cell carcinoma (SCC) is low, and there have been only a few cases of skull metastases serving as the first sign of malignancy with skull mass and epidural bleeding; however, no similar cases have been reported regarding that of hematoma. Read More

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http://dx.doi.org/10.7181/acfs.2020.00129DOI Listing

A Potential Mechanism of Tumor Progression during Systemic Infections Via the Hepatocyte Growth Factor (HGF)/c-Met Signaling Pathway.

J Clin Med 2020 Jul 1;9(7). Epub 2020 Jul 1.

Department of Surgery, National Defense Medical College; 3-2 Namiki, Tokorozawa 359-8513, Japan.

Background: Increasing evidence has demonstrated that postoperative infectious complications (PICs) after digestive surgery are significantly associated with negative long-term outcomes; however, precise mechanisms of how PICs affect the poor long-term survival remain unclear. Here, we focused on the hepatocyte growth factor (HGF)/c-Met signaling pathway as one of those mechanisms. In the clinical setting, serum HGF levels were measured in the patients with sepsis and those with PICs after undergoing esophagectomy. Read More

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http://dx.doi.org/10.3390/jcm9072074DOI Listing

Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer.

Cancers (Basel) 2020 Jul 1;12(7). Epub 2020 Jul 1.

Maimónides Biomedical Research Institute of Córdoba (IMIBIC), E14004 Córdoba, Spain.

Liquid biopsy may assist in the management of cancer patients, which can be particularly applicable in pancreatic ductal adenocarcinoma (PDAC). In this study, we investigated the utility of circulating cell-free DNA (cfDNA)-based markers as prognostic tools in metastatic PDAC. Plasma was obtained from 61 metastatic PDAC patients, and cfDNA levels and fragmentation were determined. Read More

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http://dx.doi.org/10.3390/cancers12071754DOI Listing

Alectinib in the treatment of ocular metastases of ALK rearranged non small cell lung cancer: Description of 2 case reports.

Medicine (Baltimore) 2020 Jul;99(27):e21004

Division of Medical Oncology A, Policlinico Umberto I, Sapienza University of Rome, Rome.

Rationale: Choroidal metastasis is a rare metastatic location although the most common intraocular neoplasm. In general, choroidal metastases respond favorably to systemic therapy targeted toward the primary neoplasm. In patients with choroidal metastasis of ALK rearranged non small cell lung cancer (NSCLC), targeted therapy using Alk inhibitors gradually replaced radiotherapy as the best treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000021004DOI Listing

Prognostic nomogram in patients with metastatic adenoid cystic carcinoma of the salivary glands.

Eur J Cancer 2020 Jul 3;136:35-42. Epub 2020 Jul 3.

Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy.

Background: Distant metastases in adenoid cystic carcinoma (ACC) are common. There is no consensus on the management of metastatic disease because no therapeutic approach has demonstrated improvement in overall survival (OS) and because of prolonged life expectancy. The aim of this study is to build and validate a prognostic nomogram for metastatic ACC patients. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.05.013DOI Listing

Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells.

Oncol Rep 2020 Jul 23;44(1):371-381. Epub 2020 Apr 23.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan.

Epithelial‑mesenchymal transition (EMT) is considered a crucial event in the development of cancer metastasis. Metformin is a drug used in the treatment of type 2 diabetes. Recently, increasing evidence has indicated that metformin possesses anti‑tumor activities. Read More

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http://dx.doi.org/10.3892/or.2020.7595DOI Listing

Breath Metabolomics Provides an Accurate and Noninvasive Approach for Screening Cirrhosis, Primary, and Secondary Liver Tumors.

Hepatol Commun 2020 Jul 26;4(7):1041-1055. Epub 2020 Apr 26.

Department of Quantitative Health Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.

Hepatocellular carcinoma (HCC) and secondary liver tumors, such as colorectal cancer liver metastases are significant contributors to the overall burden of cancer-related morality. Current biomarkers, such as alpha-fetoprotein (AFP) for HCC, result in too many false negatives, necessitating noninvasive approaches with improved sensitivity. Volatile organic compounds (VOCs) detected in the breath of patients can provide valuable insight into disease processes and can differentiate patients by disease status. Read More

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http://dx.doi.org/10.1002/hep4.1499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327218PMC

Early T Stage Is Associated With Poor Prognosis in Patients With Metastatic Liver Colorectal Cancer.

Front Oncol 2020 18;10:716. Epub 2020 Jun 18.

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Clinically, a considerable portion of patients with early T stage who were supposed to have a low distant metastatic probability were diagnosed with metastatic liver colorectal cancer (CRLM). Our study aims to evaluate the prognostic value of the T stage for metastatic patients and establish a convenient individual assessment model for clinicians to explore preoperative predictors. The mRNA profiles of colorectal tumors ( = 19) were obtained by microarray at our clinical center. Read More

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http://dx.doi.org/10.3389/fonc.2020.00716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314979PMC

The Prevalence and associated Factors for Liver Metastases, Development and Prognosis in newly diagnosed Epithelial Ovarian Cancer: A large Population-Based Study from the SEER Database.

J Cancer 2020 8;11(16):4861-4869. Epub 2020 Jun 8.

Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, People's Republic of China.

Primary Epithelial Ovarian Cancer (EOC), a malignant gynecologic disease, is considered one of the leading causes of mortality in women. The development of Liver Metastases (LM) in women with primary ovarian cancer commonly results in a poorer prognosis. This retrospective population-based study aims to measure the prevalence, prognostic factors, and associated risk factors for epithelial ovarian cancer patients with liver metastases (EOCLM). Read More

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http://dx.doi.org/10.7150/jca.40590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330699PMC

PET/Magnetic Resonance Imaging Applications in Abdomen and Pelvis.

Magn Reson Imaging Clin N Am 2020 Aug;28(3):369-380

Joint Department Medical Imaging, University Health Network, 585 University Avenue, Toronto, Ontario M5G 2N2, Canada. Electronic address:

This article gives a brief overview of the current clinical applications in PET/magnetic resonance (MR) imaging in abdominal diseases. Initial technical developments concentrated on improvement of attenuation correction. Significant enhancements have been achieved, which is now considered solved and useable for clinical routine. Read More

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http://dx.doi.org/10.1016/j.mric.2020.03.010DOI Listing

Liver metastases from pituitary carcinomas mimicking visceral well-differentiated neuroendocrine tumors: a series of four cases.

Diagn Pathol 2020 Jul 4;15(1):81. Epub 2020 Jul 4.

Division of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Background: Pathologists frequently encounter neuroendocrine tumors (NETs) presenting as multiple liver masses in routine practice. Most often, these are well-differentiated tumors with characteristic histologic features. In contrast, pituitary carcinoma is very rare, and there is limited data on its natural history and pathologic characterization. Read More

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http://dx.doi.org/10.1186/s13000-020-00997-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335443PMC

Oligometastatic adrenocortical carcinoma: the role of image-guided thermal ablation.

Eur Radiol 2020 Jul 3. Epub 2020 Jul 3.

Internal Medicine Unit, Clinical and Biological Sciences Department, University of Turin, San Luigi Gonzaga University Hospital, Regione Gonzole 10, 10043 Orbassano, Turin, Italy.

Objectives: To evaluate the impact of image-guided ablation of liver and lung metastases from adrenocortical carcinoma (ACC).

Methods: Patients with oligometastatic ACC (liver and lung metastases) who underwent image-guided ablation were retrospectively included in the study. Complete ablation (CA) at the first contrast-enhanced CT control, local tumor progression (LTP), local tumor progression-free survival (LTPFS), liver disease-free survival (LDFS), and overall survival (OS) were evaluated. Read More

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http://dx.doi.org/10.1007/s00330-020-07019-wDOI Listing

Long-term survival after hepatectomy for metachronous liver metastasis of pancreatic ductal adenocarcinoma: a case report.

Surg Case Rep 2020 Jul 3;6(1):157. Epub 2020 Jul 3.

Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-Ku, Kitakyushu, 802-0077, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies. The prognosis for recurrence after surgery is extremely unfavorable, and liver metastasis of PDAC confers poor prognosis despite resection.

Case Presentation: A 69-year-old man was admitted to our hospital for further examination and treatment, including surgery for a pancreatic tumor. Read More

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http://dx.doi.org/10.1186/s40792-020-00924-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334331PMC

[The role of liver transplantation in nonresectable colorectal liver metastases].

Chirurg 2020 Jul 3. Epub 2020 Jul 3.

Klinik für Allgemein‑, Viszeral- und Gefäßchirurgie, Am Klinikum 1, 07747, Jena, Deutschland.

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http://dx.doi.org/10.1007/s00104-020-01233-4DOI Listing

A multicentre, international, observational study on transarterial chemoembolisation in colorectal cancer liver metastases: Design and rationale of CIREL.

Dig Liver Dis 2020 Jun 30. Epub 2020 Jun 30.

Université Paris Descartes, Sorbonne Paris-Cité, Assistance Publique Hôpitaux de Paris, Service d'hepatogastroentérologie et d'oncologie digestive, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France.

Background: About 70-80% of patients with colorectal liver metastases appear as ineligible for a curative treatment approach. Transarterial chemoembolisation (TACE) using irinotecan-eluting beads has emerged as a promising treatment option in cases with irresectable liver metastases. Despite being in clinical practice for years, little is known about the treatment characteristics and outcomes when used as per routine hospital practice. Read More

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http://dx.doi.org/10.1016/j.dld.2020.05.051DOI Listing

Tumor rupture in hepatoblastoma: A high risk factor?

Pediatr Blood Cancer 2020 Jul 3:e28549. Epub 2020 Jul 3.

Gustave Roussy, Department of Children and Adolescents Oncology, Université Paris-Saclay, Villejuif, France.

Background: Hepatoblastoma tumor rupture is a high-risk criterion in the SIOPEL 3/4 protocol. Little is known about the outcome of these children.

Methods: Radiological signs of possible tumor rupture, defined as peritoneal effusion, peritoneal nodules, or hepatic subcapsular hematoma, were reported in 24 of 150 patients treated for hepatoblastoma in France from January 2000 to December 2014 after central radiological expert review. Read More

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http://dx.doi.org/10.1002/pbc.28549DOI Listing

Incidental primary breast cancer detected on surveillance Ga-DOTATATE PET/CT in a patient with metastatic neuroendocrine carcinoma.

Radiol Case Rep 2020 Aug 25;15(8):1344-1347. Epub 2020 Jun 25.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 601 N. Caroline Street, Baltimore 21287, MD, USA.

We present a case of a 53-year-old woman with metastatic neuroendocrine tumor, presumed primary in the small intestine with metastases to the liver and mesenteric lymph nodes. The patient was being treated with lanreotide and followed with somatostatin receptor (SSTR)-targeted 68Ga-labeled 1,4,7,10-tetraazacyclododecane-', '','''-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotate (Ga-DOTATATE) positron emission tomography - computed tomography (PET/CT). On a follow-up exam, the patient's primary and metastatic disease had improved but she had new Ga-DOTATATE-avid lesions in the right breast and right axilla. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322489PMC

The impact of multidisciplinary team management on outcome of hepatic resection in liver-limited colorectal metastases.

Sci Rep 2020 Jul 2;10(1):10871. Epub 2020 Jul 2.

Chirurgia Epatobiliare, Università Cattolica del Sacro Cuore-IRCCS, Rome, Italy.

Hepatic resection is the gold standard treatment for patients affected by liver-limited colorectal metastases. Reports addressing the impact of multidisciplinary team (MDT) evaluation on survival are controversial. The aim of this study was to evaluate the benefit of MDT management in these patients in our Institution experience. Read More

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http://dx.doi.org/10.1038/s41598-020-67676-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331814PMC

Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis.

PLoS One 2020 2;15(7):e0235623. Epub 2020 Jul 2.

Project of Development of Liquid Biopsy Diagnosis, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.

Pancreatic cancer is an aggressive, solid tumor, with a grave prognosis. Despite surgical treatment in patients with pancreatic cancer, the rate of recurrence is high. In addition, although tumor biomarkers are frequently used to confirm advanced pancreatic cancer, this is not accurate and the biomarkers currently used cannot indicate prognosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235623PLOS