48,713 results match your criteria Liver Metastases


Primary vaginal adenocarcinoma of intestinal type or occult metastatic colon cancer: a diagnostic dilemma from a vaginal skin tag.

Int J Womens Health 2019 1;11:223-228. Epub 2019 Apr 1.

Department of Gynaecological Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK,

The presentation of a new vaginal lesion could represent a variety of diagnoses from benign warts to more sinister primary malignancies. Rarely, a new lesion could represent a metastatic deposit from a malignancy elsewhere in the body. Colonic carcinomas are the third most common malignancy, frequently metastasising to the liver and lung. Read More

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http://dx.doi.org/10.2147/IJWH.S142002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448537PMC

[A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases].

Zhongguo Fei Ai Za Zhi 2019 Apr;22(4):228-232

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.

Background: A number of patients with lung cancer have distant metastases at the time of diagnosis. The most common sites for metastases are liver, brain, etc. However pancreatic metastasis is relatively rare, with an insidious onset and poor prognosis. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.04.05DOI Listing

The value of cytoreductive nephrectomy on the survival of metastatic renal carcinoma patients based on the number of site-specific metastases.

PLoS One 2019 23;14(4):e0215861. Epub 2019 Apr 23.

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: There has been significant uncertainty in the selection of candidates for cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (mRCC). This report investigates the influence of site-specific metastases (bone, brain, liver, and lung) on the survival benefit of CN.

Methods: Within the Surveillance, Epidemiology and End Results database (2010-2014), 1113 mRCC patients treated with CN (n = 618) or no surgery (NS, n = 495) met the selection criteria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215861PLOS
April 2019
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Qualitative and quantitative variations in liver function thresholds among clinical trials in cancer: a need for harmonization.

Cancer Chemother Pharmacol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hematology-Oncology, Tufts Medical Center, Boston, MA, 02111, USA.

Purpose: The liver is critically involved in drug metabolism pathways and the potential for hepatic toxicity is significant with specific cancer therapeutics. Variations in the definition of liver function thresholds that may generate heterogeneity of toxicity and efficacy outcomes across therapeutics trials in cancer require assessment.

Methods: A random sample of therapeutic trials in cancer (n = 500, general category), trials using hepatotoxic drugs (abiraterone, pazopanib: n = 181), trials using drugs metabolized by the liver (doxorubicin, vincristine: n = 606), and therapeutic trials in hepatic dysfunction (n = 49) were each identified on clinicaltrials. Read More

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http://link.springer.com/10.1007/s00280-019-03821-6
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http://dx.doi.org/10.1007/s00280-019-03821-6DOI Listing
April 2019
1 Read

Gallbladder Metastases: A Report of Two Cases.

Case Rep Oncol 2019 Jan-Apr;12(1):235-240. Epub 2019 Mar 19.

Virginia Tech Carilion School of Medicine, Division of Gastroenterology and Hepatology, Roanoke, Virginia, USA.

Introduction: Metastasis to the gallbladder is not common and usually manifests an advanced stage of malignancy. Herein, we report a case of triple negative high grade invasive ductal carcinoma of breast with a metastatic lesion to the gallbladder.

Case Presentation: The patient is a 52-year-old female diagnosed with invasive ductal carcinoma treated with mastectomy and chemotherapy. Read More

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https://www.karger.com/Article/FullText/497818
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http://dx.doi.org/10.1159/000497818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465751PMC
March 2019
1 Read

Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.

Nat Biomed Eng 2018 Jun 23;2(6):443-452. Epub 2018 Apr 23.

Laboratory of Nano- and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Metastatic disease remains the primary cause of mortality in cancer patients. Yet the number of available in vitro models to study metastasis is limited by challenges in the recapitulation of the metastatic microenvironment in vitro, and by difficulties in maintaining colonized-tissue specificity in the expansion and maintenance of metastatic cells. Here, we show that decellularized scaffolds that retain tissue-specific extracellular-matrix components and bound signalling molecules enable, when seeded with colorectal cancer cells, the spontaneous formation of three-dimensional cell colonies that histologically, molecularly and phenotypically resemble in vivo metastases. Read More

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http://www.nature.com/articles/s41551-018-0231-0
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http://dx.doi.org/10.1038/s41551-018-0231-0DOI Listing
June 2018
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A hypothesis on paradoxical privileged portal vein metastasis of hepatocellular carcinoma. Can organ evolution shed light on patterns of human pathology, and vice versa?

Med Hypotheses 2019 May 25;126:109-128. Epub 2019 Mar 25.

Arrowhead Parmaceuticals, Madison, WI 53719, USA; University of Wisconsin, Madison, WI 53705, USA; University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

Unlike other carcinomas, hepatocellular carcinoma (HCC) metastasizes to distant organs relatively rarely. In contrast, it routinely metastasizes to liver vasculature/liver, affecting portal veins 3-10 times more often than hepatic veins. This portal metastatic predominance is traditionally rationalized within the model of a reverse portal flow, due to accompanying liver cirrhosis. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.019DOI Listing
May 2019
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Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination.

Cancers (Basel) 2019 Apr 19;11(4). Epub 2019 Apr 19.

INSERM U1053 Bordeaux Research in Translational Oncology, University of Bordeaux, 33076 Bordeaux CEDEX, France.

Gastric cancer is the third leading cause of cancer mortality worldwide. Cancer stem cells (CSC) are at the origin of tumor initiation, chemoresistance, and the formation of metastases. However, there is a lack of mouse models enabling the study of the metastatic process in gastric adenocarcinoma (GC). Read More

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http://dx.doi.org/10.3390/cancers11040560DOI Listing

An occult urothelial carcinoma with wide multiorgan metastases and its genetic alteration profiling: Case report and literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15245

Department of Comprehensive Internal Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning.

Rationale: Urothelial carcinoma, also named transitional cell carcinoma, is the most frequent occurring malignancy in the urinary system. It mainly invades the surrounding tissues and metastasizes to distant organs in later stages.

Patient Concerns: Here, we presented an unusual case of occult urothelial carcinoma primarily manifested as a multiorgan metastatic cancer in a 59-year-old man. Read More

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http://dx.doi.org/10.1097/MD.0000000000015245DOI Listing

[Clear cell kidney carcinoma revealed by cutaneous and sinus metastases: about a case and literature review].

Pan Afr Med J 2018 1;31:66. Epub 2018 Oct 1.

Service d'Oncologie Médicale, CHU de Brazzaville, République du Congo.

Kidney cancer is the third most frequent urologic cancer. Metastases usually occur in the lung, the bone and the liver. We here report a clinical case of cutaneous and sinus metastases revealing kidney cancer in a 70 year old man. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.66.16721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457736PMC
October 2018

[Safety and efficacy of transarterial embolization combined with octreotide LAR on reducing tumor burden for neuroendocrine tumor liver metastasis].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(15):1142-1146

Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

To evaluate the tumor burden reducing efficacy and safety of transcatheter arterial embolization (TAE) combined with octreotide LAR on neuroendocrine tumor liver metastasis (NETLM). Twenty-nine NETLM patients treated in the First Affiliated Hospital of Sun Yat-sen University from October 2014 to August 2018 were retrospectively recruited, including 12 males and 17 females. The mean age was 25-69(50±11) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.15.005DOI Listing

Analysis of the proteasome activity and the turnover of the serotonin 2B (HTR2B) receptor in human uveal melanoma.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

CUO-Recherche, Médecine Régénératrice, Centre de Recherche FRQS du CHU de Québec, Université Laval, Québec, Canada; Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, Canada; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Québec, QC, Canada. Electronic address:

Uveal melanoma (UM), although a very rare disease, remains a particularly aggressive type of cancer as near 50% of the UM presenting patients will also develop liver metastases within 15 years from the initial diagnostic. One of the most reliable predictive markers of UM at risk of evolving toward the formation of liver lesions is an abnormally elevated level of expression of the transcript encoding the 5-Hydroxytryptamine (serotonin) receptor 2B (HTR2B). In our previous study, we demonstrated that transcription of the HTR2B gene was under the regulatory influences of two transcription factors (TFs), NFI and RUNX1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835193010
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http://dx.doi.org/10.1016/j.exer.2019.04.013DOI Listing
April 2019
3 Reads

Nasopharyngeal carcinoma with cutaneous metastases.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of radiotherapy, Farhat Hached hospital, Sousse, Tunisia.

Introduction: Cutaneous metastases from nasopharyngeal carcinoma are extremely rare and associated with a poor prognosis.

Case Reports: We retrospectively reviewed 820 patients with nasopharyngeal carcinoma treated over a 20-year period in the radiotherapy department of Farhat Hached hospital in Sousse and Ibn Khaldoun Medical centre, Hammam Sousse. Two of these patients presented cutaneous metastases. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.005DOI Listing
April 2019
2 Reads

PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.

Background: Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and the surrounding tumor microenvironment (TME). Loss of the PTEN tumor suppressor gene is observed in 20% to 30% of prostate cancers (PCa) when first detected and the rate increases with PCa progression and advanced disease. Recent findings implicate a role for PTEN in cellular type I interferon response and immunosuppression in PCa. Read More

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http://dx.doi.org/10.1002/pros.23808DOI Listing

Intrahepatic Oxaliplatin and Systemic 5-FU +/- Cetuximab in Chemo-Naïve Patients with Liver Metastases from Colorectal Cancer.

Oncology 2019 Apr 18. Epub 2019 Apr 18.

Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.

Background: In case of response to chemotherapy, unresectable liver metastases from colorectal cancer can be converted to resectable and thereby obtain a chance of cure. The primary aim of this trial was to evaluate the response rate with intrahepatic oxaliplatin in combination with systemic 5-FU +/- cetuximab. Secondary aims were to evaluate the conversion rate from unresectable to resectable liver metastases, median progression-free survival, median overall survival, and toxicity. Read More

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http://dx.doi.org/10.1159/000499314DOI Listing
April 2019
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An exceptional group of non-small cell lung cancer difficult to diagnose: Evaluation of lipid-poor adrenal lesions.

Bosn J Basic Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Nuclear Medicine Department, Firat University Medical Faculty, Elazığ, Turkey.

In some non-small cell lung cancer (NSCLC) patients, lipid-poor adrenal adenomas cannot be adequately differentiated from metastases using imaging methods. Invasive diagnostic procedures also have a low negative predictive value (NPV) in such cases. The current study aims to establish a specific and clinically practical metabolic parameter for lipid-poor adrenal lesions (ALs) in NSCLC patients. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3837DOI Listing
April 2019
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A Phase II Trial of Concurrent Temozolomide and Hypofractionated Stereotactic Radiotherapy for Complex Brain Metastases.

Oncologist 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Purpose: Complex brain metastases (BMs), such as large lesions, lesions within or close to eloquent locations, or multiple recurrent/progressive BMs, remain the most challenging forms of brain cancer because of decreased intracranial control rates and poor survival. In the present study, we report the results from a single institutional phase II trial of concurrent temozolomide (TMZ) with hypofractionated stereotactic radiotherapy (HFSRT) in patients with complex brain metastases, including assessment of its feasibility and toxicity.

Patients And Methods: Fifty-four patients with histologically proven primary cancer and complex BMs were enrolled between 2010 and 2015. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0702DOI Listing
April 2019
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Leptomeningeal Metastasis in a Breast Cancer Treated with Two Lines of Intrathecal Chemotherapy - a Case Report.

Klin Onkol 2019 ;32(2):139-142

Background: Leptomeningeal metastasis (LM) in breast cancer is associated with a poor prognosis. Although no randomised trial has demonstrated that intrathecal chemotherapy actually prolongs survival, this treatment is considered standard of care in this setting. The prognosis of patients with LM is poor, with a median overall survival time of less than 6 months. Read More

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http://dx.doi.org/10.14735/amko2018139DOI Listing
January 2019
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LATERAL NECK DISSECTION FOR AGGRESSIVE VARIANTS OF WELL-DIFFERENTIATED THYROID CANCER.

Endocr Pract 2019 Apr;25(4):328-334

Well-differentiated thyroid cancer (WDTC) is characterized by favorable disease course and excellent survival. However, some histologic subtypes, known as aggressive histologic variants (AHVs), present a more aggressive behavior than conventional WDTC. The aim of this study was to evaluate the pattern of nodal involvement and factors influencing prognosis in N1b patients with AHVs. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0503
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http://dx.doi.org/10.4158/EP-2018-0503DOI Listing
April 2019
2 Reads

Focal Liver Uptake on FDG PET/CT Without CT Correlate: Utility of MRI in the Evaluation of Patients With Known Malignancy.

AJR Am J Roentgenol 2019 Apr 17:1-7. Epub 2019 Apr 17.

1 Department of Radiology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, MA.

The purpose of this study was to determine the significance and utility of MRI in evaluation of focal hepatic uptake on FDG PET/CT without a CT correlate in patients with known malignancy. In this retrospective study, we identified 36 of 1851 patients between 2005 and 2012 with known malignancy (19 women, 17 men; mean age, 56.1 years old) who had focal hepatic uptake on FDG PET/CT without a CT correlate and follow-up MRI within 100 days for assessment of uptake. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.21035
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http://dx.doi.org/10.2214/AJR.18.21035DOI Listing
April 2019
2 Reads

Metastasis from glioblastoma multiforme: a meta-analysis.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):424-433. Epub 2019 Apr 11.

Chairman of the Program of Postgraduation in Neurooncology of the Teaching and Research Institute at Hospital Sirio-Libanês, São Paulo, SP.

Objective: Extracranial metastases of glioblastoma multiforme (GBM) are rare due to the short survival experienced by the patients. Therefore, the natural history of GBM metastases remains elusive. The identification of clinical factors promoting GBM metastases may help elucidate the mechanisms of tumor cell invasion in the brain. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.424DOI Listing
March 2019
2 Reads

Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia.

Background: Survival in metastasized cutaneous melanoma (CM) has been improved with the advent of inhibitors of immune checkpoints CTLA4 and PD-1. In contrast, the response rate for inhibition of these checkpoints in uveal melanoma (UM) is very low. Other checkpoints including IDO and TIGIT may be targetable. Read More

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http://dx.doi.org/10.1002/cam4.2167DOI Listing
April 2019
1 Read

Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases.

Int J Endocrinol 2019 12;2019:9871319. Epub 2019 Mar 12.

Division of General Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, USA.

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly present with metastatic disease, and the liver is the most frequent metastatic site. Herein, we studied whether primary tumor site affects survival in patients with GEP-NETs and liver metastases (NELM). As a secondary endpoint, we studied whether extrahepatic disease and surgical resection impact survival in this patient population. Read More

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https://www.hindawi.com/journals/ije/2019/9871319/
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http://dx.doi.org/10.1155/2019/9871319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434277PMC
March 2019
2 Reads

Brain Metastasis in Papillary Serous Adenocarcinoma of the Endometrium.

Rev Bras Ginecol Obstet 2019 Apr 16. Epub 2019 Apr 16.

Department of Specialized Medicine, Universidade Federal do Piauí, Teresina, PI, Brazil.

Background:  Most endometrial cancers (75%) are diagnosed in early stages (stages I and II), in which abnormal uterine bleeding is the most frequent clinical sign. When the diagnosis is performed in stage IV, the most common sites of metastasis are the lungs, liver and bones. Central nervous system (CNS) metastasis is a rare condition. Read More

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http://dx.doi.org/10.1055/s-0039-1683353DOI Listing
April 2019
5 Reads

ASO Author Reflections: Perioperative Genomic Profiles and Prognosis of Peripheral and Perihepatic Circulating Tumor DNA in Patients with Colorectal Liver Metastases.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1245/s10434-019-07360-5DOI Listing

A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer.

Surg Endosc 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepato-Biliary and Pancreatic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: The laparoscopic approach to liver resection has experienced exponential growth in recent years. However, evidence-based guidelines are needed for its safe future progression. The main aim of our study was to perform a systematic review and meta-analysis comparing the short- and long-term outcomes of laparoscopic and open liver resections for colorectal liver metastases (CRLM). Read More

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http://dx.doi.org/10.1007/s00464-019-06774-2DOI Listing
April 2019
1 Read

SPINE METASTASIS OF INTRACRANIAL HEMANGIOPERICYTOMA: CASE REPORT OF TWO TREATMENTS.

Acta Ortop Bras 2019 Mar-Apr;27(2):108-112

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas da da (IOT-HCFMUSP), Instituto de Ortopedia e Traumatologia, Grupo de Cirurgia de Coluna, Laboratório de Investigações Médicas, São Paulo, SP, Brazil.

Objective: To report the use of two techniques (radiosurgery and vertebrectomy) on the same patient for the treatment of two metastases in different sites of the spine arising from intracranial hemangiopericytoma. Intracranial hemangiopericytomas are rare, comprising approximately 2.4% of meningeal tumors and <1% of all tumors of the central nervous system. Read More

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http://dx.doi.org/10.1590/1413-785220192702176299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442711PMC
April 2019
3 Reads

Outcomes of central hepatectomy versus extended hepatectomy.

Hepatobiliary Pancreat Dis Int 2019 Mar 26. Epub 2019 Mar 26.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia. Electronic address:

Background: Central hepatectomy (CH) is more difficult than extended hepatectomy (EH) and is associated with greater morbidity. In this modern era of liver management with aims to prevent post-hepatectomy liver failure (PHLF), there is a need to assess outcomes of CH as a parenchyma-sparing procedure for centrally located liver tumors.

Methods: A total of 178 major liver resections performed by specialist surgeons from two Australian tertiary institutions between June 2009 and March 2017 were reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14993872193004
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http://dx.doi.org/10.1016/j.hbpd.2019.03.005DOI Listing
March 2019
1 Read

Solitary adrenal metastasis from advanced gastric cancer invading duodenal bulb with situs inversus totalis: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15244

Department of the General Surgery.

Rationale: Situs invsersus totalis (SIT) is a rare anomaly featured by complete inversion of abdominal and thoracic organs. Adrenal metastasis is often encountered as part of advanced systemic dissemination, which is usually unresectable. Few published cases reported the adrenal metastasis from gastric cancer with SIT and the treatment of gastrectomy combined with adrenalectomy, especially with intraoperative radiotherapy (IORT). Read More

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http://dx.doi.org/10.1097/MD.0000000000015244DOI Listing
April 2019
1 Read

Incidental Uptake in Benign Gynecomastia on 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Breast Imaging and.

A 54-year-old man with mesenteric carcinoid tumor metastatic to the liver completed staging Ga-DOTATATE PET/CT demonstrating uptake in multiple hepatic lesions consistent with liver metastases with additional asymmetric increased uptake in the right greater than the left breast. Subsequent bilateral diagnostic mammogram revealed benign right greater than left gynecomastia without suspicious underlying mass. With Food and Drug Administration approval of Ga-DOTATATE and the increased use of this analog in neuroendocrine tumor imaging, this case illustrates a relevant example of uptake that can potentially mimic malignancy. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9715
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http://dx.doi.org/10.1097/RLU.0000000000002597DOI Listing
April 2019
4 Reads

Tspan8 is expressed in breast cancer and regulates E-cadherin / catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.

J Pathol 2019 Apr 14. Epub 2019 Apr 14.

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106, Freiburg, Germany.

Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma and melanoma. We present a first study on the expression and function of Tspan8 in breast cancer. Tspan8 protein was present in the majority of human primary breast cancer lesions and metastases in the brain, bone, lung, and liver. Read More

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http://dx.doi.org/10.1002/path.5281DOI Listing
April 2019
2 Reads

Increased expression of SLC46A3 to oppose the progression of hepatocellular carcinoma and its effect on sorafenib therapy.

Biomed Pharmacother 2019 Apr 10;114:108864. Epub 2019 Apr 10.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China. Electronic address:

Hepatocellular carcinoma (HCC) prognosis remains dismal due to postsurgical recurrence and distant metastasis. Therefore, novel prognostic biomarkers and therapeutic targets for HCC therapy are urgently needed to improve the survival of liver cancer patients. Our evidence suggests that SLC46A3 (the gene solute carrier family 46 (sodium phosphate), member 3) is a member of the SLC46 family and has a potential role in the progression and treatment of HCC. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108864DOI Listing
April 2019
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2.023 Impact Factor

Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Epithelial cell polarity regulator Crumbs3 (Crb3), a mammalian homolog within the Drosophila Crb gene family, was initially identified as an essential embryonic development factor. It is recently implicated in tumor suppression, though its specific functions are controversial. We here demonstrate that Crb3 strongly promotes tumor invasion and metastasis of human colon adenocarcinoma cells. Read More

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http://dx.doi.org/10.1002/ijc.32336DOI Listing
April 2019
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KRAS mutational status impacts pathologic response to pre-hepatectomy chemotherapy: a study from the International Genetic Consortium for Liver Metastases.

HPB (Oxford) 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA. Electronic address:

Background: A major response to pre-hepatectomy chemotherapy has been associated with improved survival in patients who undergo resection of colorectal liver metastases (CRLM). However, the role of tumor biology, as exemplified by overall and codon-specific KRAS mutational status, in predicting response to chemotherapy is not well defined.

Methods: Pathologic response was characterized as minor or major depending on the percentage of remnant viable cells (>50% vs <50%, respectively). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1365182X193049
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http://dx.doi.org/10.1016/j.hpb.2019.03.368DOI Listing
April 2019
4 Reads

Lu/Sm-Ethylenediamine Tetramethylene Phosphonic Acid Cocktail: A Novel Palliative Treatment for Patients with Bone Metastases.

Cancer Biother Radiopharm 2019 Apr 12. Epub 2019 Apr 12.

6 Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.

Background: Production of effective, low-cost, and efficient radiopharmaceuticals is an important task and requires further research and clinical studies. In this clinical trial, safety and efficacy of Lu-177/Sm-153 ethylenediamine tetramethylene phosphonic acid (EDTMP) cocktail has been evaluated for pain relief of bone metastases.

Materials And Methods: Twenty-five patients with the mean age of 55. Read More

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http://dx.doi.org/10.1089/cbr.2018.2683DOI Listing

Biliary Peritonitis due to a Ruptured Amebic Liver Abscess Mimicking a Periampullary Tumor and Liver Metastases with the Elevation of CA 19-9 and CA 125: A Case Report.

GE Port J Gastroenterol 2019 Mar 12;26(2):121-124. Epub 2018 Jun 12.

bDepartment of Surgery, Hospital Nacional Dos de Mayo, Lima, Peru.

Introduction: An amebic liver abscess is the most common presentation of extraintestinal amebiasis. This condition is the result of a parasite infection caused by .

Materials And Methods: We report a case of a 53-year-old male who presented with abdominal pain in the right upper quadrant, jaundice, and a 10-kg weight loss within a 1-month span. Read More

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http://dx.doi.org/10.1159/000489721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454388PMC
March 2019
1 Read

Tumor enhancement of colorectal liver metastases on preoperative gadobutrol-enhanced MRI at 5 minutes post-contrast injection is associated with overall survival post-hepatectomy.

Quant Imaging Med Surg 2019 Feb;9(2):312-317

Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Previous studies have demonstrated that target tumor enhancement (TTE) of colorectal cancer liver metastases (CRCLM) on 10-minute delayed phase gadobutrol-enhanced MRI is associated with overall survival post-hepatectomy. The purpose of this study was to determine whether TTE of CRCLM on preoperative gadobutrol-enhanced MRI measured at 5-minute delayed phase is also associated with overall survival. We performed a single-institution, REB-approved, retrospective study of 121 patients with CRCLM who had received a clinical gadobutrol-enhanced MRI after treatment with chemotherapy and prior to liver surgery between January 1, 2006 and December 31, 2012. Read More

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http://dx.doi.org/10.21037/qims.2018.10.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414770PMC
February 2019

Metastasis of submandibular gland carcinoma to the toe bone: a case report.

Br J Oral Maxillofac Surg 2019 Apr 8. Epub 2019 Apr 8.

Department of Orthopedics Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, 12 Health Road, Shijiazhuang, Hebei 050011, PR China. Electronic address:

Adenoid cystic carcinoma (ACC) is rare. One of its characteristics is a high rate of distant metastasis, and the most common site is the lungs, followed by the brain and liver. Bony metastases account for up to 1. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.03.011DOI Listing
April 2019
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A unique case of eyelid metastasis from chondroid chordoma.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):287-289

Department of Pathology, The First Affiliated Hospital of Zhengzhou University; Department of Pathology, Basic Medicine College of Zhengzhou University, Zhengzhou, China.

A unique case of eyelid metastasis from nasopharyngeal chondroid chordoma in a 63-year-old woman was reported. Chordomas are rare tumors of the bone deriving from remnants of the embryonic notochord. Histologically, the tumor showed lobulated structure and concludes two types of cells: liquid drop cell and small round/cubic cell. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_387_18DOI Listing
April 2019
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Morbidity and mortality of bone metastases in advanced adrenocortical carcinoma: a multicenter retrospective study.

Eur J Endocrinol 2019 May;180(5):311-320

Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, Orbassano, University of Turin, Turin, Italy.

Introduction Adrenocortical carcinoma (ACC) is a rare cancer that commonly spreads to the liver, lungs and lymph nodes. Bone metastases are infrequent. Objective The aim of this report was to describe the clinical characteristics, survival perspective, prognostic factors and frequency of adverse skeletal-related events (SREs) in patients with ACC who developed bone metastasis. Read More

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http://dx.doi.org/10.1530/EJE-19-0026DOI Listing
May 2019
4 Reads

Non-small cell lung cancer presenting as "psoas muscle syndrome".

Monaldi Arch Chest Dis 2019 Apr 5;89(1). Epub 2019 Apr 5.

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Monaldi Hospital, Naples.

Lung cancer is the leading cause of cancer-related death worldwide and majority of patients are diagnosed in advanced/metastatic disease stage. Sites of distant metastases mainly include contralateral lung, lymph nodes, brain, bones, adrenal glands and liver; skeletal muscles metastases (SMMs) are less common. Psoas muscle and diaphragm metastases are mainly found during autopsy, as their involvement commonly is asymptomatic. Read More

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https://www.monaldi-archives.org/index.php/macd/article/view
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http://dx.doi.org/10.4081/monaldi.2019.1012DOI Listing
April 2019
6 Reads

Primary hepatic follicular dendritic cell sarcoma: A case report.

World J Clin Cases 2019 Mar;7(6):785-791

Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Follicular dendritic cell sarcoma (FDCS) is an uncommon type of tumor with low incidence. To date, no standard treatment for the disease has been established. Surgery remains the main treatment. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448081PMC
March 2019
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Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus - case series and literature review.

Z Gastroenterol 2019 Apr 9;57(4):501-507. Epub 2019 Apr 9.

Department of Internal Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Hepatocellular carcinomas (HCC) that extend into the vena cava and the right atrium have a poor prognosis. Surgical approaches including partial hepatectomy and thrombectomy are the most frequently reported treatment options. However, most patients with advanced HCC are not eligible for complex surgical interventions due to reduced liver function, comorbidities, and metastases. Read More

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http://dx.doi.org/10.1055/a-0855-4469DOI Listing
April 2019
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Prospective and prognostic factors for hepatic metastasis of gastric carcinoma: A retrospective analysis.

J Cancer Res Ther 2019 ;15(2):298-304

Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, Zhongshan, Dalian, Liaoning Province, China.

Aims: The aim of the study was to prospectively explore the prognostic factor for gastric cancer with liver metastasis (GCLM), since no prognostic factor was reported to be consistently significant across studies.

Patients And Methods: One hundred and five patients with GCLM treated at our center between January 1, 2010, and March 31, 2016, were included and their clinical data were retrospectively analyzed. The univariate analyses were first applied for identify the potential independent prognostic and predictive factors for liver metastasis. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_576_17DOI Listing
January 2019
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Radiofrequency ablation of liver metastasis: potential impact on immune checkpoint inhibitor therapy.

Eur Radiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Percutaneous radiofrequency ablation (RFA), a generally accepted alternative therapy for patients with liver metastases, is a minimally invasive approach with a favorable safety profile and a lower rate of major complications. The use of RFA or combined RFA plus resection can produce total tumor clearance in patients with unresectable liver metastases. However, the relatively high rate of local tumor progression has prevented the widespread use of RFA. Read More

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http://dx.doi.org/10.1007/s00330-019-06189-6DOI Listing
April 2019
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Neuroendocrine Liver Metastases.

Cardiovasc Intervent Radiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Diagnostic and Interventional Radiology, Pisa University Hospital, Via Paradisa 2, 56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s00270-019-02216-7DOI Listing

The role of hormone therapy and chemotherapy in oligometastatic prostate cancer.

ESMO Open 2019 12;4(Suppl 1):e000471. Epub 2019 Mar 12.

Department of Urology, Juntendo University, Tokyo, Japan.

Oligometastatic disease was proposed by Hellman and Weichselbaum in 1995 as an intermediate tumour state between localised lesions and widespread metastases, characterised by the limited number and size of metastases in specific organs such as lung, liver, bone or even brain. The oligometastatic state has increasingly been recognised as a unique clinical state during which local ablative treatment can be effective in several types of cancer, including prostate cancer. However, the role of systemic therapy, such as hormone therapy and chemotherapy, is not yet well known. Read More

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http://dx.doi.org/10.1136/esmoopen-2018-000471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435248PMC
March 2019
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Phase I clinical trial of decitabine (5-aza-2'-deoxycytidine) administered by hepatic arterial infusion in patients with unresectable liver-predominant metastases.

ESMO Open 2019 5;4(2):e000464. Epub 2019 Mar 5.

Oncology, Universitair ziekenhuis Brussel, Brussel, Belgium.

DNA demethylating agents may increase the immunogenicity of malignant tumours and increase the efficacy of subsequent treatment with immune check point inhibitors. We investigated the safety of administrating the demethylating agent decitabine by hepatic arterial infusionin patients with unresectable liver meta stases from solid tumours in a dose escalation phase I clinical trial. A total of nine eligible patients were enrolled and initiated study treatment at three different dose levels (two patients at 10, four at 15 and six at a dose level of 20mg decitabine/m2/day) (per protocol there was no intent to escalate the dose above the median tolerated intravenous dose level). Read More

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http://dx.doi.org/10.1136/esmoopen-2018-000464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435241PMC
March 2019
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Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases.

Sarcoma 2019 10;2019:1960593. Epub 2019 Mar 10.

Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

Introduction: Primary cardiac sarcoma (PCS) has a poor prognosis compared to other sarcomas due to late presentation, challenging resection, incidence of metastases, and limited efficacy of systemic therapies.

Methods: A medical record search engine was queried to identify patients diagnosed with PCS from 1992 to 2017 at the University of Michigan.

Results: Thirty-nine patients with PCS had a median age of 41 years (range 2-77). Read More

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http://dx.doi.org/10.1155/2019/1960593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431449PMC
March 2019
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Laparoscopic versus open liver resection in the posterosuperior segments: a sub-group analysis from the OSLO-COMET randomized controlled trial.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

The Intervention Center, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Norway; Department of HPB Surgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway.

Background: Laparoscopic liver resection in the posterosuperior segments is technically challenging. This study aimed to compare the perioperative outcomes for laparoscopic and open resection of colorectal liver metastases located in the posterosuperior segments.

Methods: This was a subgroup analysis of the OSLO-COMET randomized controlled trial, where 280 patients were randomly assigned to open or laparoscopic parenchyma-sparing liver resections of colorectal metastases. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.358DOI Listing