3,772 results match your criteria Liver International[Journal]


The effect of oral contraceptive pill cessation on hepatocellular adenoma diameter: a retrospective cohort study.

Liver Int 2019 Feb 18. Epub 2019 Feb 18.

University of Groningen, University Medical Center Groningen, Division of Hepatopancreatobiliary Surgery and Liver Transplantation, The Netherlands.

Background & Aims: Hepatocellular Adenomas (HCA) are rare, hormone driven, benign liver tumors. HCA >50mm are associated with hemorrhage and malignant transformation. Guidelines recommend cessation of oral contraceptive pills (OCP) for size reduction, however, it is currently unknown how HCA respond to cessation of OCP. Read More

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http://dx.doi.org/10.1111/liv.14074DOI Listing
February 2019

Molecular epidemiology of acute HCV infection in HIV-positive patients from Hong Kong, Taipei, Tokyo.

Liver Int 2019 Feb 16. Epub 2019 Feb 16.

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Acute hepatitis C virus (HCV) infections have been increasingly reported among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the Asia-Pacific region. It remains unknown whether international network of HCV transmission has occurred in this region.

Methods: HIV-positive patients with acute HCV infection, defined as HCV seroconversion within a year or documented acute hepatitis with seroconversion, diagnosed in Hong Kong, Taipei, and Tokyo during 2010-2016 were included in this molecular epidemiology study. Read More

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http://doi.wiley.com/10.1111/liv.14073
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http://dx.doi.org/10.1111/liv.14073DOI Listing
February 2019
3 Reads

Long-term outcomes of patients with hepatitis B virus -related acute on chronic liver failure: an observational cohort study.

Liver Int 2019 Feb 12. Epub 2019 Feb 12.

Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Background And Aims: The long-term outcomes of patients with hepatitis B virus -related acute-on-chronic liver failure (HBV-ACLF) remain unclear. The main aims of study was to compare the 5-year survival rate and incidence rate of hepatocellular carcinoma (HCC) between patients with HBV-ACLF and HBV-cirrhosis.

Methods: Clinical data of patients with ACLF, compensated cirrhosis and decompensated cirrhosis who survived more than 3 months after diagnosis were collected. Read More

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http://dx.doi.org/10.1111/liv.14072DOI Listing
February 2019
1 Read

Use of Dual X-ray Absorptiometry in men with advanced cirrhosis to predict sarcopenia-associated mortality risk.

Liver Int 2019 Feb 12. Epub 2019 Feb 12.

Austin Hospital Liver Transplant Unit, VIC, 3084.

Introduction: Reduced muscle area on CT scan is an independent predictor of mortality in cirrhosis. We examine for the first time the relationship between Dual Energy X-ray Absorptiometry (DEXA) lean mass parameters on outcomes in cirrhotic men awaiting liver transplantation.

Materials And Methods: We retrospectively reviewed DEXA scans performed during transplant assessment between 2001 and 2016. Read More

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http://dx.doi.org/10.1111/liv.14071DOI Listing
February 2019
2 Reads
4.850 Impact Factor

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis.

Liver Int 2019 Feb 9. Epub 2019 Feb 9.

Department of Medicine I, University of Bonn, Bonn, Germany.

Background: Remodeling of extracellular matrix (ECM) is crucial in progressive liver fibrosis. Collagen type III desposition has been shown in acute decompensation. ECM is compiled of deposition of various components. Read More

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http://dx.doi.org/10.1111/liv.14070DOI Listing
February 2019
2 Reads

Autotaxin, Bile Acid Profile and Effect of IBAT Inhibition in Primary Biliary Cholangitis Patients with Pruritus.

Liver Int 2019 Feb 8. Epub 2019 Feb 8.

Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre,, Newcastle University, Newcastle upon Tyne, United Kingdom.

Background &aims: Pruritus is a common symptom in patients with primary biliary cholangitis (PBC) for which ileal bile acid transporter (IBAT) inhibition is emerging as a potential therapy. We explored the serum metabonome and gut microbiota profile in PBC patients with pruritus and investigated the effect of GSK2330672, an IBAT inhibitor.

Methods: We studied fasting serum bile acids (BAs), autotaxin and faecal microbiota in 22 PBC patients with pruritus at baseline and after two weeks of GSK2330672 treatment. Read More

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http://dx.doi.org/10.1111/liv.14069DOI Listing
February 2019
1 Read

Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non-alcoholic fatty liver disease.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Aims: We compared the effects of weight loss induced with the glucagon-like peptide-1 agonist liraglutide, with that of lifestyle modification, followed by weight maintenance after discontinuing intervention, in obese adults with NAFLD.

Methods: Thirty obese (mean age 40.7 ± 9. Read More

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http://dx.doi.org/10.1111/liv.14065DOI Listing
February 2019
1 Read

The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

Inserm, U1016,Institut Cochin, Paris, 75014, France.

Background/aims: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, is frequently associated with hepatocellular carcinoma (HCC). Our recent data revealed that HNF4α level was decreased in mouse and human HCCs with activated β-catenin signaling. In addition, increasing HNF4α level by miR-34a inhibition slowed tumor progression of β-catenin activated HCC in mice. Read More

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http://dx.doi.org/10.1111/liv.14068DOI Listing
February 2019
2 Reads

MicroRNA-30b Regulates Insulin Sensitivity by Targeting SERCA2b in Non-alcoholic Fatty Liver Disease.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, China.

Background & Aims: Insulin resistance is strongly associated with nonalcoholic fatty liver disease, a chronic, obesity-related liver disease. Increased endoplasmic reticulum stress plays an important role in the development of insulin resistance. In this study, we investigated the roles of miRNAs in regulating ER stress in the liver of rats with obesity. Read More

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http://dx.doi.org/10.1111/liv.14067DOI Listing
February 2019
2 Reads
4.850 Impact Factor

TCRβ Repertoire of Memory T cell Reveals Potential Role for E.coli in the Pathogenesis of Primary Biliary Cholangitis.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China.

Background: Primary biliary cholangitis (PBC) is an organ-specific, T cell mediated autoimmune disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, especially the pyruvate dehydrogenase E2 complex (PDC-E2). However, the molecular mechanism of breakdown of self-tolerance is still unclear.

Methods: A combination of multiplex-PCR and immune repertoire sequencing (IR-seq) was used for a standardized analysis of memory T cell receptor (TCR) β-chain repertoire of PBC patient and healthy volunteers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14066
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http://dx.doi.org/10.1111/liv.14066DOI Listing
February 2019
2 Reads

Autoimmune hepatitis: current and future therapeutic options.

Liver Int 2019 Feb 4. Epub 2019 Feb 4.

Toronto Centre for Liver Disease, Division of Gastroenterology and Hepatology, University Health Network, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada.

Autoimmune hepatitis (AIH) is a rare immune-mediated liver disease with few major advances in treatment options over the last several decades. Available options are effective in most patients albeit are imprecise in their mechanisms. Novel and more tolerable induction regimens and alternative options for management of patients intolerant or with suboptimal response to traditional therapies including in the post-transplant setting remain an important unmet need. Read More

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http://dx.doi.org/10.1111/liv.14062DOI Listing
February 2019

Second Line Chemotherapy in Biliary Tract Cancer: Outcome and Prognostic Factors.

Liver Int 2019 Feb 4. Epub 2019 Feb 4.

Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.

Background & Aims: The prognosis of biliary tract cancer (BTC) is poor. Standard treatment for advanced BTC is a chemotherapy (CT) with gemcitabine and cisplatin. Phase-III evidence for a second line (2L) CT is lacking. Read More

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http://dx.doi.org/10.1111/liv.14063DOI Listing
February 2019
1 Read

Ideal cardiovascular health metrics and the risk of non-alcoholic fatty liver disease: A cross-sectional study in northern China.

Liver Int 2019 Feb 3. Epub 2019 Feb 3.

Sanbo Brain Institute, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Background And Purpose: The components of ideal cardiovascular health (CVH) metrics have been shown to be associated with non-alcoholic fatty liver disease (NAFLD). The present study aimed to determine the association between ideal CVH metrics and NAFLD.

Methods: A total of 10,511 participants (47. Read More

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http://dx.doi.org/10.1111/liv.14060DOI Listing
February 2019
4.850 Impact Factor

Impact of antiretroviral therapy containing tenofovir disoproxil fumarate on the survival of patients with HBV and HIV coinfection.

Liver Int 2019 Feb 3. Epub 2019 Feb 3.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University Hospital, Taipei, Taiwan.

Background: Tenofovir disoproxil fumarate (TDF) is active against both HBV and HIV. Whether the introduction of TDF-containing combination antiretroviral therapy (cART) has improved the outcome of HIV/HBV-coinfected patients remains unclear in areas of higher HBV endemicity.

Methods: We retrospectively reviewed medical records of newly diagnosed antiretroviral-naïve HIV-infected patients between 2007 and 2015. Read More

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http://dx.doi.org/10.1111/liv.14059DOI Listing
February 2019
1 Read

Injury pattern recognition to discriminate competing causes of liver injury.

Liver Int 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, East Carolina University, Greenville, North Carolina.

Background: Competing causes of liver injury may be difficult to discriminate. Characterization of the typical phenotype of each injury defined by latency, time to improvement and biochemical pattern, could be helpful to identify the most likely of competing causes.

Methods: Liver injury characteristics of both bortezomib-associated drug-induced liver injury (DILI) and hepatitis B virus (HBV) reactivation associated with bortezomib are derived from PubMed listed publications. Read More

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http://dx.doi.org/10.1111/liv.14056DOI Listing
January 2019

Klotho-beta and fibroblast growth factor 19 expression correlates with early recurrence of resectable hepatocellular carcinoma.

Liver Int 2019 Jan 30. Epub 2019 Jan 30.

Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei City, Taiwan.

Background And Aims: Fibroblast growth factor 19 (FGF19) and fibroblast growth factor receptor 4 (FGFR4) signaling play critical roles in hepatocarcinogenesis. This study explored the potential of FGF19 and FGFR4 related biomarkers in predicting early tumor recurrence (ETR) and survival in patients with resectable hepatocellular carcinoma (HCC).

Methods: We examined the mRNA expressions of FGF19, FGFR4, klotho-beta (KLB), cyclin D1 (CCND1), and FGF4 in 151 surgically resected, primary unifocal HCCs through quantitative real-time polymerase chain reaction. Read More

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http://doi.wiley.com/10.1111/liv.14055
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http://dx.doi.org/10.1111/liv.14055DOI Listing
January 2019
4 Reads
4.850 Impact Factor

The interaction of nonalcoholic fatty liver disease and smoking on mortality among adults in the United States.

Liver Int 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in Western countries. Smoking and diabetes mellitus (DM) have been shown to increase mortality, however, whether NAFLD adds to the detrimental effect of smoking in DM and non-DM patients is unknown. We evaluated the possible interactive effect of NAFLD and smoking on mortality risk in a U. Read More

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http://dx.doi.org/10.1111/liv.14058DOI Listing
January 2019
1 Read

Herbal-induced liver injury: The price to pay for a healthier life?

Authors:
Raúl J Andrade

Liver Int 2019 Feb;39(2):257-259

Unidad de Gestión Clínica de Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.

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http://dx.doi.org/10.1111/liv.14003DOI Listing
February 2019

Classifications and misclassification in cholangiocarcinoma.

Liver Int 2019 Feb;39(2):260-262

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1111/liv.13998DOI Listing
February 2019

Long-lasting persistence of large B-cell clones in hepatitis C virus-cured patients with complete response of mixed cryoglobulinaemia vasculitis.

Liver Int 2019 Jan 28. Epub 2019 Jan 28.

Division of Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Background & Aims: Hepatitis C virus (HCV)-related mixed cryoglobulinaemia vasculitis (MCV) is characterized by the expansion of rheumatoid factor-producing B-cell clones. The aim of this study was to assess whether B-cell clones may persist in these patients after the clearance of the virus with antiviral therapy, and whether their persistence influences clinical outcomes.

Methods: Forty-five HCV-cured MCV patients were followed up for a median of 18. Read More

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http://dx.doi.org/10.1111/liv.14053DOI Listing
January 2019
2 Reads

Nationwide Estimates and Risk Factors of Hospital Readmission in Patients with Cirrhosis in the United States.

Liver Int 2019 Jan 28. Epub 2019 Jan 28.

Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The burden of cirrhosis on the healthcare system is substantial and growing. Our objectives were to estimate the readmission rates and hospitalization costs, as well as to identify risk factors for 90-day readmission in patients with cirrhosis.

Methods: We conducted a weighted analysis of the 2014 Nationwide Readmission Database to identify adult patients with cirrhosis-related complications in the United States and assessed readmission rates at 30, 60, and 90 days post-index hospitalization. Read More

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http://dx.doi.org/10.1111/liv.14054DOI Listing
January 2019
1 Read

Stopping immunosuppressive treatment in autoimmune hepatitis (AIH): Is it justified (and in whom and when)?

Liver Int 2019 Jan 22. Epub 2019 Jan 22.

Liver Unit, Northern General Hospital, Sheffield Teaching Hospital's NHS Foundation Trust, Sheffield, UK.

Background: Initial treatment of autoimmune hepatitis (AIH) with prednisolone ± azathioprine is based on randomised controlled trials. Many patients receive long-term immunosuppressive treatment to prevent disease relapse; this strategy has a weaker evidence base.

Aim: To consider whether immunosuppressive treatment (IST) withdrawal in AIH is justified and to develop a rationale for patient selection. Read More

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http://doi.wiley.com/10.1111/liv.14051
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http://dx.doi.org/10.1111/liv.14051DOI Listing
January 2019
7 Reads

The modification of quantity and quality of muscle mass improves the cognitive impairment after TIPS.

Liver Int 2019 Jan 22. Epub 2019 Jan 22.

Department of Clinical Medicine, "Sapienza" University of Rome, Rome, Italy.

Background: Hepatic encephalopathy (HE) is the major complication of transjugular intrahepatic portosystemic shunt (TIPS). In cirrhotic patients, a correlation between sarcopenia and HE has been suggested.

Aim: To evaluate the evolution of the skeletal muscle quantity and quality at CT scan and of the patients' cognitive impairment (both overt and minimal HE) before and after TIPS. Read More

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http://dx.doi.org/10.1111/liv.14050DOI Listing
January 2019
1 Read

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.

Liver Int 2019 Jan 21. Epub 2019 Jan 21.

Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Background And Aims: Bile acids are now accepted as central signalling molecules for the regulation of glucose, amino acid and lipid metabolism. Adrenal gland cortex cells express the bile acid receptors farnesoid X receptor (FXR), the G protein-coupled bile acid receptor (TGR5) and the sphingosine-1-phosphate receptor 2 (S1PR2). We aimed to determine the effects of cholestasis and more specifically of bile acids on cortisol production. Read More

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http://doi.wiley.com/10.1111/liv.14052
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http://dx.doi.org/10.1111/liv.14052DOI Listing
January 2019
11 Reads
4.850 Impact Factor

Treatment with metformin is associated with a prolonged survival in patients with hepatocellular carcinoma.

Liver Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

Background: Hepatocellular carcinoma (HCC) is one of the most lethal cancers. Nutrition- and life style-associated risk factors are increasingly prevalent. Metformin, the mainstay of type 2 diabetes mellitus (T2DM)-treatment, reduces the risk of hepatocarcinogenesis. Read More

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http://doi.wiley.com/10.1111/liv.14048
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http://dx.doi.org/10.1111/liv.14048DOI Listing
January 2019
4 Reads

The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis.

Liver Int 2019 Jan 18. Epub 2019 Jan 18.

Department of Medicine, University of Padova, Padova, Italy.

Background & Aims: Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests.

Methods: Two hundred and fourteen patients with cirrhosis were enrolled. Read More

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http://doi.wiley.com/10.1111/liv.14046
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http://dx.doi.org/10.1111/liv.14046DOI Listing
January 2019
6 Reads

Association between non-alcoholic fatty liver disease and risk of atrial fibrillation in adult individuals: An updated meta-analysis.

Liver Int 2019 Jan 18. Epub 2019 Jan 18.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Background & Aims: Recent studies examined the association between non-alcoholic fatty liver disease (NAFLD) and risk of atrial fibrillation (AF) in adults, but the findings have been inconsistent. We provided a quantitative estimate of the magnitude of the association between NAFLD and risk of AF.

Methods: We searched publication databases using predefined keywords to identify observational studies (published up to December 14, 2018), in which NAFLD was diagnosed by biopsy, imaging or biochemistry and AF was diagnosed by medical history and electrocardiograms. Read More

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http://dx.doi.org/10.1111/liv.14044DOI Listing
January 2019
1 Read

Disparities in uptake of direct-acting antiviral Therapy for Hepatitis C among people who inject drugs in a Canadian setting.

Liver Int 2019 Jan 17. Epub 2019 Jan 17.

British Columbia Centre on Substance Use, Vancouver, BC, Canada.

Background & Aims: Despite the high burden of hepatitis C virus (HCV) infection among people who inject drugs (PWID), uptake of interferon-based therapies has been extremely low. Increasing availability of direct-acting antiviral (DAA)-based therapies offers the possibility of rapid treatment expansion with the goal of controlling the HCV epidemic. We evaluated DAA-based treatment uptake among HCV-positive PWID in Vancouver after introduction of DAAs in the government drug formulary. Read More

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http://doi.wiley.com/10.1111/liv.14043
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http://dx.doi.org/10.1111/liv.14043DOI Listing
January 2019
5 Reads

Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis.

Liver Int 2019 Jan 13. Epub 2019 Jan 13.

Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Background: In cirrhosis, a decrease in hepatic venous pressure gradient (HVPG) > 10% after acute iv propranolol (HVPG response) is associated with a lower risk of decompensation and death. Only a part of patients are HVPG responders and there are no accurate non-invasive markers to identify them. We aimed at discovering metabolomic biomarkers of HVPG responders to propranolol. Read More

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http://doi.wiley.com/10.1111/liv.14042
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http://dx.doi.org/10.1111/liv.14042DOI Listing
January 2019
9 Reads

Treatment with direct-acting antivirals for HCV decreases but does not eliminate the risk of hepatocellular carcinoma.

Liver Int 2019 Jan 13. Epub 2019 Jan 13.

Hospital Universitario Austral, Pilar, Argentina.

Background & Aims: Data from Europe and North America have been published regarding the risk of developing hepatocellular carcinoma (HCC) after treatment with direct antiviral agents (DAA). We proposed to evaluate cumulative incidence and associated risk factors for de novo HCC.

Methods: This was a prospective multicentre cohort study from Latin America including 1400 F1-F4-treated patients with DAAs (F3-F4 n = 1017). Read More

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http://dx.doi.org/10.1111/liv.14041DOI Listing
January 2019
1 Read
4.850 Impact Factor

Reply to Mantovani: "Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes".

Liver Int 2019 Jan 7. Epub 2019 Jan 7.

Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK.

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http://doi.wiley.com/10.1111/liv.14026
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http://dx.doi.org/10.1111/liv.14026DOI Listing
January 2019
5 Reads

Insights into paediatric non-alcoholic fatty liver disease from genetic variants.

Liver Int 2019 Jan 7. Epub 2019 Jan 7.

Metabolic Research Laboratories-Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1111/liv.14020
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http://dx.doi.org/10.1111/liv.14020DOI Listing
January 2019
5 Reads

Assessing the Safety of Beta Blocker Therapy in Cirrhosis Patients with Ascites: A Meta-Analysis.

Liver Int 2019 Jan 7. Epub 2019 Jan 7.

Department of Medicine, Division of Gastroenterology and Hepatology, Alameda Health System - Highland Hospital, Oakland, CA.

Background & Aims: Beta blocker therapy is effective at reducing risks of variceal bleeding. However, beta blockers may detrimentally exacerbate the underlying hemodynamic changes in cirrhosis. A systematic review and meta-analysis was performed to evaluate impact of beta blockers on all-cause mortality among cirrhosis patients with ascites. Read More

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http://doi.wiley.com/10.1111/liv.14040
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http://dx.doi.org/10.1111/liv.14040DOI Listing
January 2019
9 Reads

Prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among Asian American adults in the United States.

Liver Int 2018 Dec 29. Epub 2018 Dec 29.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia.

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) affects about 25% of the general population worldwide. Although epidemiology of NAFLD is well studied in the United States, there is paucity of data for the Asian Americans. Our aim was to assess the prevalence and risk factors for NAFLD among Asian Americans. Read More

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http://dx.doi.org/10.1111/liv.14038DOI Listing
December 2018
2 Reads

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival.

Liver Int 2018 Dec 29. Epub 2018 Dec 29.

Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

Background: Several lines of evidence indicate that decompensated cirrhosis is characterized by the presence of systemic inflammation. Hepatorenal syndrome (HRS-AKI) is a unique type of renal failure that occurs at late stages of cirrhosis. However, confirmation of the presence and significance of such inflammatory response in HRS-AKI is lacking. Read More

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http://dx.doi.org/10.1111/liv.14037DOI Listing
December 2018
4 Reads

The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.

Liver Int 2018 Dec 29. Epub 2018 Dec 29.

Evans Department of Medicine, Section of Gastroenterology, Boston University School of Medicine, Boston, Massachusetts.

Background & Aims: Emerging data from paediatric populations suggest that variants in the autophagy-governing immunity-related GTPase M (IRGM) gene may contribute to nonalcoholic fatty liver disease (NAFLD) susceptibility. We examined the relationship between IRGM rs13361189 variants and NAFLD in a community-based cohort of adults.

Methods: We included all Framingham Heart Study participants with available data on the IRGM rs13361189 variant, undergoing study-directed computed tomography (CT) scans of the abdomen (2002-2005). Read More

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http://doi.wiley.com/10.1111/liv.14039
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http://dx.doi.org/10.1111/liv.14039DOI Listing
December 2018
8 Reads

Coagulation failure is associated with bleeding events and clinical outcome during systemic inflammatory response and sepsis in acute-on-chronic liver failure: An observational cohort study.

Liver Int 2018 Dec 27. Epub 2018 Dec 27.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Patients with acute-on-chronic liver failure (ACLF) have coagulation failure in the setting of systemic inflammatory syndrome (SIRS), sepsis and extra-hepatic organ failures.

Methods: Consecutive ACLF patients without sepsis at baseline were assessed at days 0, 3 and 7 with thromboelastography (TEG) and specific assays (Factor VIII, von Willebrand factor [vWF], protein C and antithrombin III [ATIII]) and followed for development of sepsis, bleeding and outcome.

Results: Of 243 patients, 114 (63% ethanol related; mean age 44. Read More

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http://dx.doi.org/10.1111/liv.14034DOI Listing
December 2018
1 Read
4.850 Impact Factor

Liver disease related to alpha1-antitrypsin deficiency in French children: The DEFI-ALPHA cohort.

Liver Int 2018 Dec 27. Epub 2018 Dec 27.

Hépatologie, Gastroentérologie et Nutrition pédiatriques, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.

Background & Aims: To identify prognostic factors for liver disease in children with alpha-1 antitrypsin deficiency, irrespective of phenotype, using the DEFI-ALPHA cohort.

Methods: Retrospective, then prospective from 2010, multicentre study including children known to have alpha-1 antitrypsin blood concentration below 0.8 g/L, born in France since 1989. Read More

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http://dx.doi.org/10.1111/liv.14035DOI Listing
December 2018
2 Reads

Prediction of the varices needing treatment with non-invasive tests in patients with compensated advanced chronic liver disease.

Liver Int 2018 Dec 27. Epub 2018 Dec 27.

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Backgrounds & Aims: The Baveno VI guidelines proposed criteria including liver stiffness (LS) and platelet count to avoid screening endoscopy in patients with compensated advanced chronic liver disease (cACLD). This study was performed to validate the Baveno IV criteria and to compare its diagnostic accuracy with other non-invasive models.

Methods: Patients with cACLD who underwent laboratory tests, upper gastrointestinal endoscopy and abdominal ultrasound within 6 months of transient elastography were included. Read More

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http://doi.wiley.com/10.1111/liv.14036
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http://dx.doi.org/10.1111/liv.14036DOI Listing
December 2018
7 Reads
4.850 Impact Factor

Autoimmune hepatitis: Is the autoimmunity in the family?

Liver Int 2019 Jan;39(1):42-44

I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/liv.13989DOI Listing
January 2019

Long-term albumin administration in patients with decompensated cirrhosis. It is time for a reappraisal.

Liver Int 2019 Jan;39(1):45-48

Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum-Università di Bologna, Bologna, Italy.

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http://doi.wiley.com/10.1111/liv.13996
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http://dx.doi.org/10.1111/liv.13996DOI Listing
January 2019
8 Reads

Sustained virological response does not improve long-term glycaemic control in patients with type 2 diabetes and chronic hepatitis C.

Liver Int 2018 Dec 20. Epub 2018 Dec 20.

Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.

Background: Sustained virological response to treatment for chronic hepatitis C virus may improve short-term glucose control among patients with type 2 diabetes, but the long-term impact remains largely unknown. We used data from the Chronic Hepatitis Cohort Study to investigate the impact of sustained virological response on long-term trends in haemoglobin A1c in patients with type 2 diabetes.

Methods: "Index date" was defined as the date of treatment initiation (treated patients) or hepatitis C virus diagnosis (untreated patients). Read More

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http://dx.doi.org/10.1111/liv.14031DOI Listing
December 2018
4.850 Impact Factor

Association between serum liver enzymes and all-cause mortality: The Japan Public Health Center-based Prospective Study.

Liver Int 2018 Dec 19. Epub 2018 Dec 19.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Background & Aims: The association of serum liver enzyme levels with all-cause mortality in individuals without hepatitis B virus or hepatitis C virus infection is inconsistent. We aimed to investigate all-cause and non-liver disease mortality according to levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) stratified by hepatitis virus infection status in a Japanese cohort.

Methods: Participants were 7243 men and 13 513 women aged 40-69 years at the baseline survey in 1993-1994. Read More

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http://dx.doi.org/10.1111/liv.14030DOI Listing
December 2018
2 Reads

Potential value of urinary amatoxin quantification in patients with hepatotoxic mushroom poisoning.

Liver Int 2018 Dec 18. Epub 2018 Dec 18.

Toxicology Unit, Emergency Department, Hospital Clínic, Barcelona, Spain.

Backgorund & Aims: Mushroom poisoning with Amanita phalloides or similar species can lead to liver failure with 10-30% mortality rates. We aimed at defining the prognostic value of urinary amatoxin quantification in patients with hepatotoxic mushroom poisoning.

Methods: Data from 32 patients with hepatotoxic mushroom poisoning (Hospital Clínic Barcelona, 2002-16) in whom urinary amatoxins were determined (ELISA) were retrospectively reviewed. Read More

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http://doi.wiley.com/10.1111/liv.14028
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http://dx.doi.org/10.1111/liv.14028DOI Listing
December 2018
3 Reads

Mortality trends of liver diseases from 1981 to 2016 and the projection to 2035 in Taiwan: An age-period-cohort analysis.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: Projections on liver diseases mortality can provide a basis for evaluating the World Health Organization's "25 by 25" goal and can help healthcare systems design appropriate control strategies. This study evaluated whether the 25 by 25 goal can be achieved in Taiwan and discussed possible future control strategies.

Methods: Age-period-cohort models are used to estimate the mortality trends of liver diseases from 1981 to 2016 and project these trends to 2035. Read More

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http://dx.doi.org/10.1111/liv.14027DOI Listing
December 2018
2 Reads

Serum adipocyte fatty acid-binding protein levels: An indicator of non-alcoholic fatty liver disease in Chinese individuals.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Background & Aims: Serum adipocyte fatty acid-binding protein (A-FABP) is closely correlated to metabolic disorders such as obesity and insulin resistance (IR). Non-alcoholic fatty liver disease (NAFLD) is a typical feature of IR in the liver. The aim of this study was to explore the relationship between serum A-FABP levels and NAFLD. Read More

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http://dx.doi.org/10.1111/liv.14021DOI Listing
December 2018
4 Reads

A double-blind randomized controlled trial to assess efficacy of bromocriptine in cirrhotic patients with hepatic parkinsonism.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Parkinsonism like features can be seen in cirrhotics, possibly related to alterations in brain dopamine metabolism, transport and receptor integrity at basal ganglia. Hepatic parkinsonism is often not suspected and only ammonia-reducing therapies are given to such patients. We investigated the efficacy and safety of bromocriptine, a dopaminergic agent, in patients with hepatic parkinsonism. Read More

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http://dx.doi.org/10.1111/liv.14024DOI Listing
December 2018
6 Reads
4.850 Impact Factor

Hepatitis C late relapse in patients with directly acting antiviral-related sustained virological response at week 12.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Laboratory for the Identification of Prognostic Factors of Response to the Treatment Against Infectious Diseases, University of Campania, Naples, Italy.

Aim: The aim of the present study was to identify, among the patients with failure to DAA regimen, those with a late relapse (after the achievement of a sustained virological response at week 12) and to characterize the clinical, epidemiological and virological features of these patients.

Material And Methods: A total of 129 HCV patients with non-response to an IFN-free regimen were enrolled. Sanger sequencing of NS3, NS5A and NS5B was performed at failure by home-made protocols. Read More

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http://dx.doi.org/10.1111/liv.14025DOI Listing
December 2018
3 Reads

Tolerability and effectiveness of generic direct-acting antiviral drugs in eradication of hepatitis C genotype 4 among Egyptian patients.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: We investigated tolerability and effectiveness of generic, less expensive direct antiviral drugs in the treatment of hepatitis C virus genotype 4 (HCV GT-4) in an Egyptian cohort.

Patients And Methods: Retrospectively, we analysed data from 648 patients with HCV GT4 attending Alexandria Main University Hospital from January 2016 to May 2017 [488 treatment naïve/160 treatment-experienced/288 with chronic hepatitis/360 with cirrhosis]. Patients received generic sofosbuvir/ledipasvir (n = 168, treatment naïve = 136, treatment-experienced = 32) or sofosbuvir/daclatasvir (n = 480, treatment naïve = 352, treatment-experienced = 128) ± ribavirin. Read More

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http://dx.doi.org/10.1111/liv.14022DOI Listing
December 2018

Intraductal papillary neoplasm of the bile duct (IPNB): a rare precursor of cholangiocarcinoma.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Laboratory tests in an asymptomatic 70-year-old Caucasian man revealed biological cholestasis with an increased level of γ-GT. Abdominal tomography showed a mass in the left hepatic lobe, nearly four centimeters in diameter and associated with a dilated left bile duct. PET imaging revealed high glucose uptake. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14023
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http://dx.doi.org/10.1111/liv.14023DOI Listing
December 2018
6 Reads