1,067,888 results match your criteria Liver International[Journal]


Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Gastroenterology and Hepatology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The recommendation in regards to screening for non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients differs in major guidelines.

Aim: To study the prevalence of NALFD and advanced fibrosis among T2DM patients.

Methods: Cross-sectional study of consecutive adult T2DM patients attending the Diabetes Clinic of a university hospital. Read More

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December 2018
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Partial Costotransversectomy and Corpectomy for Thoracic Spinal Metastatic Disease: Operative Technique and Nuances: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurologic Surgery, Mayo Clinic Florida, Jacksonville, Florida.

We describe the operative approach and management for thoracic metastatic disease in a 78-yr-old man with worsening mechanical lower back and left-sided thoracic radicular pain. Imaging of the thoracic spine revealed an osteolytic T11 mass with destruction of the left T11 pedicle and transverse process. Biopsy confirmed spinal metastasis from the liver. Read More

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December 2018

Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress.

Environ Toxicol Pharmacol 2018 Dec 5;65:60-65. Epub 2018 Dec 5.

College of Pharmacy, Guangxi Medical University, Guangxi, Nanning, 530021, PR China. Electronic address:

Our previous studies show that vitamin C (VC) plays promising hepatoprotection in mice. Intrahepatic exposure of perfluorooctane sulfonate (PFOS) can induce dose-dependent cytotoxicity. However, pharmacology-based assessment of VC on PFOS remains uninvestigated. Read More

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December 2018

Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2018 Dec 5;165:173-181. Epub 2018 Dec 5.

National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Science and Technology of China, Hefei, 230026, China. Electronic address:

In this study, a novel analysis strategy for progressively targeted screening and characterization of drug ingredients from in vitro to in vivo was proposed based on ultra-high performance liquid chromatography-tandem mass spectrometry for comprehensive characterization of in vivo metabolic profile of Polygalae radix (PR). First, an in vitro chemical profile of PR was described with the assistance of UNIFI™ software. The characteristic neutral small molecule losses were summarized to distinguish different chemical structures in the PR extract. Read More

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December 2018

Lecithin doped electrospun poly(lactic acid)-thermoplastic polyurethane fibers for hepatocyte viability improvement.

Colloids Surf B Biointerfaces 2018 Sep 28;175:264-271. Epub 2018 Sep 28.

College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

The development of hepatocyte cultures in vitro holds great significance in the study of bioartificial liver support systems. Electrospun fiber cultures have received widespread attention as an effective method to culture hepatocytes in vitro. Polylactic acid (PLA) -a synthetic polymer with high biocompatibility and biodegradability- is widely used to fabricate electrospun fibers in the biomedical field. Read More

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September 2018

Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS Ⅲ), and its challenge against Aeromonas hydrophila infection.

Fish Shellfish Immunol 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, PR China.

The present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS Ⅲ) (initial body weight: 7.48g). Read More

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December 2018

Early-life exposure to the endocrine disruptor 17-α-ethinylestradiol induces delayed effects in adult brain, liver and ovotestis proteomes of a self-fertilizing fish.

J Proteomics 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Evolutionary and Adaptive Physiology - Institute of Life, Earth and Environment - University of Namur, 61 Rue de Bruxelles, B5000 Namur, Belgium.

Early-life represents a critically sensitive window to endocrine disrupting chemicals, potentially leading to long-term repercussions on the phenotype later in life. The mechanisms underlying this phenomenon, referred to as the Developmental Origins of Health and Disease (DOHaD), are still poorly understood. To gain molecular understanding of these effects, we exposed mangrove rivulus (Kryptolebias marmoratus) for 28 days post hatching (dph) to 4 and 120 ng/L 17-α-ethinylestradiol, a model xenoestrogen. Read More

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December 2018

Impact of strain and duration of thermal stress on carcass yield, metabolic hormones, immunological indices and the expression of HSP90 and Myogenin genes in broilers.

Res Vet Sci 2018 Nov 30;122:193-199. Epub 2018 Nov 30.

Department of Animal Wealth Development, Zagazig University, Sharkia, Egypt. Electronic address:

The aim was to elucidate the effects of strain and the duration of thermal stress (36 °C) on the carcass yield, metabolic hormones, immunological parameters and the relative expression of liver heat shock protein 90 (HSP90) and Myogenin genes. Two hundred and seventy day-old chicks (135 of each breed; Ross 308 and Cobb 500) were used in this trial. The birds were divided into 3 equal groups (CON: thermoneutral condition; S and S groups were subjected to 4 and 6 h of daily thermal stress, respectively. Read More

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November 2018

Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address:

Drug-induced liver toxicity is the most frequent cause of acute liver failure worldwide. Hepatotoxicity caused by acetaminophen (ACT) overdose is mediated by its metabolic product promoting oxidative stress and activation of inflammatory mediators. Nuclear factor erythroid-related factor-2 (Nrf-2) induces the release of cytoprotective enzymes in response to electrophilic or oxidative stress and is considered a promising therapeutic target. Read More

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December 2018

The IRS/PI3K/Akt signaling pathway mediates olanzapine-induced hepatic insulin resistance in male rats.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Endocrinology and Metabolism Group, Sydney Institute of Health Sciences, Sydney Institute of Traditional Chinese Medicine, Sydney, NSW 2000, Australia. Electronic address:

Aims: Chronic treatment with antipsychotics, especially most of atypical ones, leads to development of metabolic abnormalities. Olanzapine is an atypical antipsychotic widely used in the treatment of schizophrenia and bipolar disorder. The mechanisms underlying olanzapine-induced metabolic adverse effects in the liver, however, remain unclear. Read More

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December 2018

Geraniol protects against lipopolysaccharide and D-galactosamine-induced fulminant hepatic failure by activating PPARγ.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Infectious Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. Electronic address:

Geraniol (GOH), a natural component of plant essential oils, exhibits potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the protective effects and mechanisms of GOH on lipopolysaccharide (LPS)/d-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF). Mice were treated with GOH (12. Read More

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December 2018

Relaxin in liver transplantation: A personal perspective.

Mol Cell Endocrinol 2018 Dec 11. Epub 2018 Dec 11.

The Dumont-UCLA Transplant Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at University of California, Los Angeles, CA, 90095, USA. Electronic address:

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December 2018

Morbidity and mortality after transjugular intrahepatic portosystemic shunt placement in patients with cirrhosis.

Eur J Gastroenterol Hepatol 2018 Dec 13. Epub 2018 Dec 13.

Hepatology and Liver Transplant Unit, Department of Medical Area (DAME).

Objectives: Transjugular intrahepatic portosystemic shunt (TIPS) is adopted to treat refractory complications of portal hypertension, such as variceal bleeding and ascites. This study aimed to assess predictors of hepatic encephalopathy (HE) development and cumulative transplant-free survival after TIPS placement in patients with cirrhosis complicated by refractory ascites and major gastroesophageal bleeding.

Materials And Methods: Sixty-three cirrhotic patients who underwent TIPS positioning as a secondary prophylaxis of major upper gastroesophageal bleeding (N=30) or to control refractory ascites (N=33) were enrolled. Read More

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December 2018

Lipoprotein metabolism in liver diseases.

Curr Opin Lipidol 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: The liver is the central hub of lipoprotein metabolism. A complex relationship exists between dyslipidemia and chronic liver diseases (CLDs). Recent advances in the genetics of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) exemplify the pivotal role of lipoprotein metabolism in the pathogenesis of CLD. Read More

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December 2018

Alcohol and gastrointestinal cancers.

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

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December 2018

Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin angiotensin system.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Center for Nutritional Sciences, University of Kentucky, United States.

The deletion of the prorenin receptor (PRR) in adipose tissue elevates systolic blood pressure (SBP) and circulating soluble form of PRR (sPRR) in male mice fed a high-fat diet (HF). However, sex differences in the contribution of adipose-PRR and sPRR to the regulation of the renin-angiotensin system (RAS) in key organs for blood pressure control are undefined. Therefore, we assessed blood pressure and the systemic and intrarenal RAS status in adipose-PRR KO female mice. Read More

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December 2018

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach.

Mol Pharm 2018 Dec 14. Epub 2018 Dec 14.

Antibody fragment F8- mediated Interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin (ED-A). In this study, in-vivo biodistribution and arthritis targeting of radiolabeled F8-IL10 were investigated in RA patients, followed by further animal studies. Read More

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December 2018

[Analysis of distant metastasis and related factors of head and neck mucosal melanoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1078-1081

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100010, China.

To analyze the characteristics and related factors of distant metastasis of head and neck mucosal melanoma, so as to provide better help for the treatment and the control of patients' survival. Retrospectively analyze the patients of head and neck mucosal melanoma who were treated in our hospital from January 2004 to December 2016, through follow-up, of which 37 cases of patients with metastatic disease were analyzed which including the incidence of distant metastasis, specific metastasis and prognosis, time, etc.The age and gender of the patients were controlled, and 37 cases of 1∶1 were selected randomly in the patients who had no distant metastasis. Read More

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[The role of fraction analysis of ferritin in diagnostic of secondary hemophagocyte syndrome].

Klin Lab Diagn 2018 ;63(1):21-27

The Federal state budget educational institution of higher education "The Pavlov First Saint Petersburg State Medical University" of Minzdrav of Russia, 197022, St. Petersburg, Russia.

The secondary hemophagocytic syndrome is a life-threatening condition characterized by non-specifc manifestations: systemic inflammatory reaction, cytopenia, liver affection, high content of ferritin in blood serum. One of manifestations of secondary hemophagocytic syndrome is decreasing of level of glycated ferritin in blood serum expressed in percentage of total level. The detection of glycated ferritin can be applied for a differentiated diagnosis with cli9nically similar conditions, including septic process. Read More

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January 2018

[The comparison of two chemiluminescent models for assessing anti-oxidative activity of blood serum of patients with liver pathology].

Klin Lab Diagn 2018 ;63(1):16-21

The Federal state budget scientifc institution "the Russian cardiologic R&D production complex" of Minzdrav of Russia, 121552, Moscow, Russia.

The comparative assessment was carried out concerning anti-oxidation activity of blood serum of patients with liver pathology using two chemiluminescent techniques with different models of free radical oxidation: «Hb-Н2О2-luminol» и «ABAP-luminol». The reliable but low correlation of results was established (r=0,798) related mainly to difference in mechanisms of initiation of free radicals and effect of blood serum on initiation process. This effect is stronger manifested in model «Hb-Н2О2-luminol». Read More

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January 2018

Acute Psychosis and Movement Disorders as First Presentations of Wilson's Disease.

Isr Med Assoc J 2018 Dec;20(12):788-789

Detpartment of Child and Adolescent Psychiatry, Jerusalem Mental Health Center, Eitanim Psychiatric Hospital, Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.

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December 2018

Transplantation of Livers from Old Donors: Pushing the Envelope Beyond the Seventh Decade.

Isr Med Assoc J 2018 Dec;20(12):765-769

Department of Transplantation, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.

Background: The lack of organs for liver transplantation has prompted transplant professionals to study potential solutions, such as the use of livers from donors older than 70 years. This strategy is not widely accepted because potential risks of vascular and biliary complications and recurrence of hepatitis C.

Objectives: To examine the efficacy and safety of liver grafts from older donors for transplantation. Read More

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December 2018

Synergistic effects of prenatal nicotine exposure and post-weaning high-fat diet on hypercholesterolaemia in rat offspring of different sexes.

Basic Clin Pharmacol Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.

Hypercholesterolaemia is considered a disease with intrauterine origin. Recently, we reported that prenatal nicotine exposure (PNE) induced an abnormal level of total cholesterol in rat offspring before and after birth. However, there was little data about sex differences in serum cholesterol level in PNE offspring. Read More

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December 2018

Put The Blame On Gastric Bypass.

Authors:
Baris D Yildiz

Liver Transpl 2018 Dec 14. Epub 2018 Dec 14.

Ankara Numune Teaching Hospital General Surgery, Sihhiye, Ankara, Turkey.

We read with great interest the article titled "Impact of prior bariatric surgery on perioperative liver transplant outcomes" by Idriss et al (1). The authors gave a unique perspective to bariatric surgery and its relation to liver transplantation (LT). Although Roux and Y gastric bypass (RYGB) used to be considered as the gold standard (2) bariatric surgery procedure; since 2014 more than 50% of all bariatric procedures are sleeve gastrectomies (SG) (3). Read More

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December 2018

Tolerability and effectiveness of generic direct-acting antiviral drugs in eradication of hepatitis C genotype 4 among Egyptian patients.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University Cairo, Egypt.

Background: We investigated tolerability and effectiveness of generic, less expensive direct antiviral drugs in the treatment of hepatitis C virus genotype 4(HCV- GT-4) in an Egyptian cohort.

Patients And Methods: Retrospectively, we analyzed data from 648 patients with HCV-GT4 attending Alexandria Main University Hospital from January 2016 to May 2017 [488 treatment naïve/160 treatment experienced/288 with chronic hepatitis/360 with cirrhosis]. Patients received generic sofosbuvir/ledipasvir (n= 168, treatment naïve = 136, treatment-experienced = 32) or sofosbuvir/daclatasvir (n= 480, treatment naïve = 352, treatment-experienced = 128) ± ribavirin. Read More

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December 2018

Intraductal papillary neoplasm of the bile duct (IPNB): a rare precursor of cholangiocarcinoma.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Laboratory tests in an asymptomatic 70-year-old Caucasian man revealed biological cholestasis with an increased level of γ-GT. Abdominal tomography showed a mass in the left hepatic lobe, nearly four centimeters in diameter and associated with a dilated left bile duct. PET imaging revealed high glucose uptake. Read More

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December 2018

The presence of varices in patients after hepatitis C eradication predicts deterioration in the FIB-4 index.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto.

Aims: The liver function of patients with hepatitis C virus (HCV) infection who obtained sustained virological response (SVR) has been known to improve after HCV eradication. However, a predictor of liver function after SVR has not been definitively identified. The aim of this retrospective study was to identify a predictor of deteriorated liver function and FIB-4 index after SVR was achieved by direct-acting antiviral (DAA) treatment. Read More

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December 2018

Liver resection versus transcatheter arterial chemoembolization for the treatment of patients with hepatocellular carcinoma and hepatic vein or inferior vena cava tumor thrombus: a propensity score matching analysis.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Background: Because of the rarity of hepatic vein tumor thrombus (HVTT) in patients with hepatocellular carcinoma, little is known about HVTT. Thus, the survival benefit of liver resection (LR) versus TACE for HCC patients with HVTT or inferior vena cava tumor thrombus (IVCTT) remains controversial. We aimed to explore the survival benefits of LR versus TACE for the treatment of these patients. Read More

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December 2018

Ultrasound Assessment of Hepatobiliary and Splenic Changes in Patients With Dengue and Warning Signs During the Acute and Recovery Phases.

J Ultrasound Med 2018 Dec 14. Epub 2018 Dec 14.

Infectious Diseases, Federal University of Triângulo Mineiro, Uberaba, Brazil.

Objectives: To evaluate whether abdominal ultrasound (US) with a gallbladder (GB) contractility study or motor function test can be used as a diagnostic tool in patients with dengue and warning signs in acute and recovery phases.

Methods: Fifty-one individuals in the acute phase of dengue presenting with warning signs (dengue group) and 49 healthy individuals without a history of dengue or hepatobiliary disease (control group) were studied with abdominal US and a GB contractility study.

Results: Statistical differences in US measurements of the liver (right lobe, P = . Read More

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December 2018

Recurrence of hereditary hemorrhagic telangiectasia after liver transplantation: clinical implications and physiopathological insights.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Gustave Roussy Cancer Campus, Département de Biologie et Pathologie Médicales, Service de Pathologie Moléculaire, Villejuif.

Liver transplantation (LT) has been proposed as a curative treatment in hereditary hemorrhagic telangiectasia (HHT) with severe hepatic involvement. We provide a long-term evaluation of graft status after LT for HHT, with a focus on the risk of recurrence. The present study included all patients prospectively followed-up after LT for HHT in the Lyon liver transplant unit from 1993 to 2010, with a survival of more than 1 year. Read More

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December 2018

Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a low amplification potential in vitro, a major limitation for the cell-based therapy of liver disorders and for ex vivo biological screens. Induced pluripotent stem cells (iPSC) may help to circumvent this obstacle, but often harbor genetic and epigenetic abnormalities limiting their potential. Here, we describe the pharmacological induction of proliferative human hepatic progenitor cells (HPC) through a cocktail of growth factors and small molecules mimicking the signaling events involved in liver regeneration. Read More

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December 2018

Targeting TGF-β signaling in Liver Cancer.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Center for Translational Medicine, Department of Surgery, George Washington University, Washington, DC, 20052.

Hepatocellular carcinoma (HCC), accounting for 85-90% of all primary liver cancers, is among the most prevalent and lethal cancers in the world, with five-year survival for advanced cases under 11%. Ineffective detection of tumors and drug resistance are some of the causal factors for therapy failure. Thus, there is an urgent need to understand the molecular mechanisms underlying drug resistance and HCC initiation. Read More

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December 2018

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

University of Michigan.

Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More

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December 2018

MicroRNAs: Unfolding the link between inositol-requiring enzyme 1α and fatty liver.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Northwestern University Feinberg School of Medicine.

Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver chemistry tests in the United States and western world. The mechanisms underlying hepatic steatosis and the progression to nonalcoholic steatohepatitis (NASH) remain incompletely understood. Multiple cellular stress pathways are believed to contribute to the pathogenesis of fatty liver, including endoplasmic reticulum (ER) stress and its adaptive unfolded protein response (UPR). Read More

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December 2018

Standardization of surgical procedures for laparoscopic Spiegel lobectomy: A single-institutional experience.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.

Introduction: Surgical techniques for Spiegel lobectomy remain technically difficult because of its deep anatomical location. Laparoscopic Spiegel lobectomy has not yet been standardized or widely reported. In the current study, we introduce technical improvements, including the liver hanging maneuver, to laparoscopic Spiegel lobectomy. Read More

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December 2018

MicroRNA-1204 promotes cell proliferation by regulating PITX1 in non-small cell lung cancer.

Cell Biol Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

MicroRNA-1204 (miR-1204), a member of the PVT1 region, may improve B cell differentiation and metastasis in breast cancer. However, the role of miR-1204 in NSCLC (non-small cell lung cancer) and its mechanism remain unclear. The GEO public database was first employed to find differentially expressed genes. Read More

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December 2018

Efficacy and safety of sofosbuvir-based therapy in hepatitis C virus recurrence post living donor liver transplant: A real life egyptian experience.

J Med Virol 2018 Dec 14. Epub 2018 Dec 14.

Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Aim: Direct acting antiviral has offered treatment of hepatitis C virus (HCV) recurrence post liver transplantation (LT) with an all-oral regimen for short duration, excellent safety profile, and high sustained virological response (SVR). The aim of this study was to evaluate the efficacy and safety of sofosbuvir (SOF)-based regimens in the real world among a cohort of Egyptian patients with recurrent HCV post living donor LT (LDLT).

Methods: Patients with HCV-G4 recurrence post-LDLT were recruited from National Committee of Control of Viral Hepatitis, Egypt, from November 2014 to May 2017. Read More

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December 2018

MSI-L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Microsatellite instability (MSI) is a prognostic marker in colorectal cancer (CRC). The biological significance of MSI-low (MSI-L) phenotype and its differences with microsatellite stable (MSS) phenotype remains unclear. The aim of this study is indicating the role of mononucleotide repeat in identifying MSI-L and revealing the association of MSI-L with elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and oncologic outcome in CRC patients. Read More

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December 2018

HER2 mCRC patients with exon 20 R784G substitution mutation do not respond to the cetuximab therapy.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The human epidermal growth factor 2 (HER2) gene undergoes various mutations that could alter its activity or respond to the antibody therapies. Cetuximab, a known anti-EGFR monoclonal antibody (mAB), is widely administered in metastatic colorectal cancer (mCRC) cases. Here we identified mCRC patients who did not respond to cetuximab (500 mg/m , q2w) after fluoropyrimidine/oxaliplatin regimen failure. Read More

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December 2018

Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency-mediated mitochondrial dysregulation.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, has significant potential for application in the treatment of urothelial carcinoma (URCa) of the bladder. Previous studies have shown that regulation of the AMP-activated serine/threonine protein kinase (AMPK)-mTOR signaling pathway enhances apoptosis by inducing autophagy or mitophagy in bladder cancer. Alteration of liver kinase B1 (LKB1)-AMPK signaling leads to mitochondrial dysfunction and the accumulation of autophagy-related proteins as a result of mitophagy, resulting in enhanced cell sensitivity to drug treatments. Read More

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December 2018

New treatment method for mucopolysaccharidosis type VI by liver transplantation.

Pediatr Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Diagnosis, National Center for Child Health and Development, Tokyo.

Background: Mucopolysaccharidosis (MPS) VI is a rare, autosomal recessive congenital metabolic disorder caused by deficient activity of the lysosomal metabolic enzyme, N-acetylgalactosamine 4-sulfatase. Enzyme replacement therapy (ERT) is current therapeutic treatment for MPS VI, while involves limited compliance to the therapy and high costs. This study aimed to develop a new method of treatment by conducting an orthotopic liver transplantation using an animal model of human MPS VI, and to evaluate and examine its effectiveness for treating MPS VI. Read More

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December 2018

Dichotomy of Notch signalling in regulating tumor immune surveillance.

Scand J Immunol 2018 Dec 13:e12744. Epub 2018 Dec 13.

Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Notch signaling is an evolutionarily conserved multifaceted pathway that controls diverse cellular processes. Its role in regulating development and tissue homeostasis is well established. Aberrant activation of the Notch pathway has been implicated in the initiation and progression of many types of cancers. Read More

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December 2018

Development of a class prediction model to discriminate pancreatic ductal adenocarcinoma from pancreatic neuroendocrine tumor by MALDI mass spectrometry imaging.

Proteomics Clin Appl 2018 Dec 13:e1800046. Epub 2018 Dec 13.

R. Casadonte, J. Kriegsmann, Proteopath GmbH, Trier, Germany.

Purpose: To define proteomic differences between pancreatic ductal adenocarcinoma (pDAC) and pancreatic neuroendocrine tumor (pNET) by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI).

Experimental Design: 93 pDAC and 126 pNET individual tissues were assembled in tissue microarrays and analyzed by MALDI MSI. The cohort was separated in a training (52 pDAC and 83 pNET) and validation set (41 pDAC and 43 pNET). Read More

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December 2018

Alpha-fetoprotein Decrease from >1000 to <500 ng/ml in Patients with Hepatocellular Carcinoma Leads to Improved Post-Transplant Outcomes.

Hepatology 2018 Dec 13. Epub 2018 Dec 13.

Division of Gastroenterology, Department of Medicine, University of California, San Francisco.

High alpha-fetoprotein (AFP) >1000 ng/ml is associated with poor outcome after liver transplant (LT) for hepatocellular carcinoma (HCC). A new national policy has been implemented for AFP >1000 requiring a decrease to <500 before LT, but there is a paucity of data on the optimal AFP threshold before LT. We aimed to evaluate the effects of a reduction in AFP from >1000 to different AFP thresholds before LT on survival and HCC recurrence after LT using the UNOS database. Read More

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December 2018

The role of inflammasome complex in ischemia-reperfusion injury.

J Cell Biochem 2018 Dec 13. Epub 2018 Dec 13.

Health research institute,, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Ischemia-reperfusion injury refers to a temporary interruption of blood flow in a tissue. Restoration of blood flow initiates the inflammation in tissue causing ischemic damage through the activation of a multiprotein complex termed inflammasome. The complex contains a receptor, mainly a member of nucleotide oligomerization domain-like receptors, that receives danger signals. Read More

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December 2018

Hepatocyte Injury Induced by Contrast-Enhanced Diagnostic Ultrasound.

J Ultrasound Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.

Objectives: Contrast-enhanced diagnostic ultrasound (US) has a potential to induce localized biological effects. The potential for contrast-enhanced diagnostic US bioeffects in liver were researched, with guidance from a report by Yang et al (Ultrasonics 2012; 52:1065-1071).

Methods: Contact and standoff scanning was performed for 10 minutes with a diagnostic US phased array at 1. Read More

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December 2018

Outbreak of myelocytomatosis caused by mutational avian leukosis virus subgroup J in China, 2018.

Transbound Emerg Dis 2018 Dec 12. Epub 2018 Dec 12.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.

Avian leukosis virus subgroup J (ALV-J) was isolated in meat-type breeder chickens for the first time in 1988 in the United Kingdom. Due to the application of an eradication program, there were fewer reports related to myelocytomatosis or ALV-J in China after 2013. However, there was another breakout almost simultaneously in six provinces of China in February 2018. Read More

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December 2018
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Useful technique for draining a large cystic tumor through the round ligament in laparoscopic left hemihepatectomy.

Asian J Endosc Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterological Surgery, Fukuyama City Hospital, Fukuyama, Japan.

Introduction: Some cystic liver tumors are huge when the diagnosis is made or surgery is needed. Although reducing tumor size by preoperative aspiration or drainage of the contents of the cystic tumor is helpful for liver resection, such procedures have a risk of tumor dissemination.

Materials And Surgical Technique: After the round ligament was dissected, a 12-Fr drainage catheter was inserted into the tumor via the round ligament under ultrasonography. Read More

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December 2018

An effective method to reduce the interplay effects between respiratory motion and a uniform scanning proton beam irradiation for liver tumors: A case study.

J Appl Clin Med Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiation Oncology, New York University Langone Medical Center, Laura and Isaac, Perlmutter Cancer Center, New York, NY, USA.

Purpose: For scanning particle beam therapy, interference between scanning patterns and interfield organ motion may result in suboptimal dose within target volume. In this study, we developed a simple offline correction technique for uniform scanning proton beam (USPB) delivery to compensate for the interplay between scanning patterns and respiratory motion and demonstrate the effectiveness of our technique in treating liver cancer.

Methods: The computed tomography (CT) and respiration data of two patients who had received stereotactic body radiotherapy for hepatocellular carcinoma were used. Read More

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December 2018

External validation of the PREDICT tool in Spanish women with breast cancer participating in population-based screening programmes.

J Eval Clin Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Epidemiology and Evaluation, IMIM-Hospital del Mar, Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain.

Rationale, Aims, And Objectives: To externally validate the PREDICT tool in a cohort of women participating in a population-based breast cancer screening programme who were diagnosed with breast cancer between 2000 and 2008 in Spain.

Methods: A total of 535 women were included in the validation study. We calculated predicted 5-year survival using the beta values from the development of the PREDICT model and predicted and observed events for a given risk groups. Read More

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December 2018
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