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Gastroenterology 2022 Jun 22. Epub 2022 Jun 22.

Division of Gastroenterology & Hepatology, University of Washington, Seattle, Washington, USA.

J Viral Hepat 2022 Jun 24. Epub 2022 Jun 24.

Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.

Viral hepatitis is caused by a heterogenous group of viral agents representing a wide range of phylogenetic groups. Many viruses can involve the liver and cause liver injury but only a subset are delineated as "hepatitis viruses" based upon their primary site of replication and tropism for hepatocytes which make up the bulk of the liver cell population. Since their discovery, beginning with the agent that caused serum hepatitis in the 1960s, the alphabetic designations have been utilized. Read More

Hepatol Commun 2022 Jun 24. Epub 2022 Jun 24.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Prior international studies have shown mixed results regarding the association of hepatitis B and hepatitis C with adverse pregnancy outcomes. We performed an updated evaluation of the prevalence of associated adverse pregnancy outcomes and evaluated trends over time of diagnosis of chronic hepatitis B (HBV) and chronic hepatitis C (HCV) in pregnant women in a national database. All pregnant women with HBV and HCV were identified from the National Inpatient Sample database 2012 to 2018. Read More

Nutrients 2022 Jun 19;14(12). Epub 2022 Jun 19.

Department of Nutrition, Texas A&M University, College Station, TX 77840, USA.

Recent studies have suggested that prevention of obesity and non-alcoholic fatty liver disease (NAFLD) should start with maternal dietary management. We previously reported disrupted methionine cycle, associated with NAFLD, in male offspring liver due to maternal high-fat (HF) diet, thus we hypothesize that maternal one-carbon supplement may reduce the risk of NAFLD in offspring via the normalizing methionine cycle. To test it, female mice (F0) were exposed to either a maternal normal-fat diet (NF group) a maternal HF diet (HF group), or a maternal methyl donor supplement (H1S or H2S group) during gestation and lactation. Read More

J Hazard Mater 2022 May 18;430:128511. Epub 2022 Feb 18.

Department of Toxicology, Anhui Medical University, Hefei 230032, China. Electronic address:

The metabolic disorders are becoming an epidemic disease endangering public health in countries. Environmental factors are mainly reason for the growth of metabolic disorders. Previous research suggests that DNA methylation is a potential mechanism. Read More

Maedica (Bucur) 2022 Mar;17(1):80-87

Department of Nephrology, AIIMS, New Delhi, India.

This study aimed to investigate the incidence, clinical characteristics, and outcomes of acute kidney injury (AKI) during pregnancy in Indian population. A prospective observational study was conducted in pregnant patients admitted to Pt. B. Read More

Sci Rep 2022 Jun 22;12(1):10548. Epub 2022 Jun 22.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis. Protocatechuic acid (PCA) is the major phenolic acid contained in the PRBE. Therefore, this study aimed to determine whether PCA is an anticarcinogenic compound in purple rice extract. Read More

BMJ Open Gastroenterol 2022 06;9(1)

Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.

Background: Despite the evidence for adverse pregnancy outcomes, non-alcoholic fatty liver disease (NAFLD) is not routinely addressed in early pregnancy. The Fatty Liver Index (FLI) has been proposed as a screening tool for NAFLD in the general population. We aim to develop mathematical models for predicting NAFLD in pregnancy and validate the FLI for first-trimester pregnant women. Read More

BMC Pregnancy Childbirth 2022 Jun 20;22(1):500. Epub 2022 Jun 20.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Preeclampsia is a multisystem disorder characterized by an abnormal vascular response to placentation associated with increased systemic vascular resistance. As liver involvement is one of the main clinical features of preeclampsia, we sought to determine if there is an association between chronic liver diseases and preeclampsia.

Methods: A retrospective matched case-control analysis was conducted in a tertiary medical center. Read More

Sante Publique 2022 ;33(5):741-751

Introduction: Co-administration of the bilié de Calmette et Guérin (BCG) and birth doses of oral polio (OPV zero) and hepatitis B (HepB BD) vaccines is strongly recommended. The objective was to determine the factors associated with this co-administration in the health district of Podor (Senegal).

Methods: This cross-sectional study was conducted among 726 children aged 12 to 23 months. Read More

Expert Opin Pharmacother 2022 Jun 19:1-7. Epub 2022 Jun 19.

Cleveland Clinic, Obstetrics and Gynecology and Women's Health Institute, Cleveland, Ohio, USA.

Introduction: Uterus transplantation introduces unique challenges regarding immunosuppression, including the effects of immunosuppressive drugs on the fetus and graft rejection during pregnancy. Although immunosuppressive regimens are based on protocols used after solid organ transplantation, in recipients of uterus grafts, the physician must consider therapy modifications based on the phase of the transplant, from the intra-operative period through to delivery.

Areas Covered: This review discusses the current immunosuppressive rationale in uterus transplantation, focusing on the therapy in each phase of the transplant. Read More

Frontline Gastroenterol 2022 21;13(4):355-357. Epub 2021 Sep 21.

Gastroenterology, St James's University Hospital, Leeds, UK.

Gastroenterol Res Pract 2022 9;2022:3663079. Epub 2022 Jun 9.

Department of Gastroenterology, Second Affiliated Hospital of Army Medical University, China.

Background: The study is aimed at evaluating the clinical attributes, types, and risk factors associated with poor outcomes in women with acute pancreatitis (AP) during pregnancy.

Methods: From 2011 to 2020, 45 antenatal mothers with AP were included in this noninterventional, retrospective study. The correlation between etiology of AP, its severity, biochemical parameters, length of stay, and treatment was analyzed. Read More

Lancet Reg Health Am 2022 May 26;9. Epub 2022 Jan 26.

Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, MS 8913, 12700 E 19th Avenue, Aurora, CO 80045, USA.

Background: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal death in low- to middle-income countries (LMIC). The American College of Obstetricians and Gynecologists (ACOG) updated diagnostic guidelines to align signs and symptoms with those associated with maternal death. We performed an observational study to ask whether ACOG guidelines were employed and associated with adverse outcomes in La Paz-El Alto, Bolivia, an LMIC. Read More

Am J Emerg Med 2022 Jun 8;58:223-228. Epub 2022 Jun 8.

SAUSHEC, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA. Electronic address:

Introduction: Eclampsia is a rare partum and puerperal condition that carries a high rate of morbidity and mortality.

Objective: This review highlights the pearls and pitfalls of the care of patients with eclampsia, including presentation, evaluation, and evidence-based management in the emergency department (ED).

Discussion: Eclampsia is a hypertensive disease of pregnancy defined by new onset tonic-clonic, focal, or multifocal seizures or unexplained altered mental status in a pregnant or postpartum patient in the absence of other causative etiologies. Read More

Front Cardiovasc Med 2022 30;9:902346. Epub 2022 May 30.

Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China.

Impaired renal function in pregnant women with preeclampsia is particularly common, yet there is no consensus about implementation. This lack of consensus is due in part to uncertainty about risks for disease progression. Limited evidence suggests that C677T gene polymorphism of 5, 10-methylenetetrahydrofolate reductase ( C677T) may affect impaired renal function in pregnant women with preeclampsia in Chinese Han population. Read More

Lancet Gastroenterol Hepatol 2022 Jul;7(7):598-599

Coalition for Global Hepatitis Elimination, The Task Force for Global Health, Decatur, GA 230030, USA.

Comput Math Methods Med 2022 6;2022:8081673. Epub 2022 Jun 6.

Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, 223300 Jiangsu, China.

This study was aimed to explore magnetic resonance imaging (MRI) based on deep learning belief network model in evaluating serum bile acid profile and adverse perinatal outcomes of intrahepatic cholestasis of pregnancy (ICP) patients. Fifty ICP pregnant women diagnosed in hospital were selected as the experimental group, 50 healthy pregnant women as the blank group, and 50 patients with cholelithiasis as the gallstone group. Deep learning belief network (DLBN) was built by stacking multiple restricted Boltzmann machines, which was compared with the recognition rate of convolutional neural network (CNN) and support vector machine (SVM), to determine the error rate of different recognition methods on the test set. Read More

Front Cell Dev Biol 2022 30;10:818621. Epub 2022 May 30.

Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil.

Maternal diabetes-induced fetal programming predisposes offspring to type 2 diabetes, cardiovascular disease, and obesity in adulthood. However, lifelong health and disease trajectories depend on several factors and nutrition is one of the main ones. We intend to understand the role of maternal diabetes-induced fetal programming and its association with a high-fat diet during lifelong in the female F1 generation focusing on reproductive outcomes and the possible changes in physiological systems during pregnancy as well as the repercussions on the F2 generation at birth. Read More

J Gastrointestin Liver Dis 2022 Jun 12;31(2):256-257. Epub 2022 Jun 12.

Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim; Clinical Cooperation Unit Healthy Metabolism, Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Diabetes Res Clin Pract 2022 Jun 9;189:109942. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria; Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Aims: Non-invasive hepatic steatosis indices can be used to assess the risk for metabolic (dysfunction) associated fatty liver disease (MAFLD). This may be helpful to detect metabolic disorders in pregnancy, specifically gestational diabetes (GDM). We aimto examine the association of these indices with parameters of glucose metabolism. Read More

BMJ Case Rep 2022 Jun 10;15(6). Epub 2022 Jun 10.

Surgical Oncology, University of Rochester Wilmot Cancer Institute, Rochester, New York, USA

Hepatic cavernous haemangioma is a benign tumour of vascular origin found within the liver. Often incidentally diagnosed, the management of these vascular masses is frequently determined by the size of the mass and symptoms associated with its compression of adjacent structures. Tumours >10 cm are known as giant haemangiomas and are associated with increased risks of compression symptoms, coagulopathies and haemorrhage. Read More

JAMA Netw Open 2022 Jun 1;5(6):e2216527. Epub 2022 Jun 1.

Telethon Kids Institute, Nedlands, Western Australia, Australia.

Importance: The management of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes.

Objective: To systematically synthesize treatment outcomes and adverse events among pregnant patients with MDR-TB.

Data Sources: PubMed, Scopus, Web of Science, and ProQuest were searched from the inception of each database through August 31, 2021. Read More

Int J Mol Sci 2022 May 27;23(11). Epub 2022 May 27.

Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Maternal obesity and consumption of a high-fat diet significantly elevate risk for pediatric nonalcoholic fatty liver disease (NAFLD), affecting 10% of children in the US. Almost half of these children are diagnosed with nonalcoholic steatohepatitis (NASH), a leading etiology for liver transplant. Animal models show that signs of liver injury and perturbed lipid metabolism associated with NAFLD begin in utero; however, safe dietary therapeutics to blunt developmental programming of NAFLD are unavailable. Read More

Front Immunol 2022 23;13:893628. Epub 2022 May 23.

Department of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Objective: To study the effect of antiviral therapy during pregnancy on the frequency of natural killer (NK) cells in peripheral blood of women with HBV DNA positive chronic hepatitis B (CHB).

Method: In total 124 female subjects were divided into four groups: 11 healthy non-pregnant women (Normal group), 26 non-pregnant women in immune tolerance period of chronic hepatitis B virus (HBV) infection (CHB group), 41 pregnant CHB women without antiviral treatment during pregnancy (Untreated group), and 46 pregnant CHB women receiving antiviral treatment during pregnancy (Treated group). The frequency of NK cells in peripheral blood were detected by flow cytometry. Read More

Saudi Med J 2022 Jun;43(6):599-609

From the Department of Neonatology (Zhang, Zhu Y, Zhu L, Chen, Yuan), Children's Hospital of Fudan University, from the Division of Neonatology (Lu), Gynecology and Obstetrics Hospital of Fudan University; and from the Key Laboratory of Neonatal Diseases (Chen), National Health Commission, Shanghai, China.

Objectives: To investigate the prevalence of preterm birth (PTB) and the risk factors for different gestational age subgroups of preterm birth in China.

Methods: We carried out a descriptive cross-sectional study encompassing all singleton live births (24 to 41 weeks) with completed data in 23 provinces in China from 2010 to 2017 during investigation period. We compared both the preterm group (24 to 36 weeks) and preterm subgroups (<32 weeks, 32 to 33 weeks, and 34 t0 36 weeks) with the term group (37 to 41 weeks). Read More

Chin Med J (Engl) 2022 04 5;135(7):860-862. Epub 2022 Apr 5.

Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.

FASEB J 2022 07;36(7):e22383

Division of Reproductive Sciences, Department of OB/GYN, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Infants born to obese mothers have a greater risk for childhood obesity and insulin resistance. However, the underlying biological mechanism remains elusive, which constitutes a significant roadblock for developing specific prevention strategies. Maternal adiponectin levels are lower in obese pregnant women, which is linked with increased placental nutrient transport and fetal overgrowth. Read More