18,885 results match your criteria Liver Disease and Pregnancy


Jaundice and Elevated Beta-Human Chorionic Gonadotropin in a Female: Duodenal Choriocarcinoma, Not Pregnancy.

Cureus 2020 May 28;12(5):e8336. Epub 2020 May 28.

Gastroenterology, Larkin Community Hospital, South Miami, USA.

A 29-year-old woman with developmental delay presented with 2.5 weeks of jaundice of the skin with accompanying microcytic anemia (hemoglobin 6.8 g/dL, mean corpuscular volume 70. Read More

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http://dx.doi.org/10.7759/cureus.8336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325344PMC

Hydroxychloroquine efficacy and safety in preventing SARS-CoV-2 infection and COVID-19 disease severity during pregnancy (COVID-Preg): a structured summary of a study protocol for a randomised placebo controlled trial.

Trials 2020 Jul 2;21(1):607. Epub 2020 Jul 2.

ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.

Objectives: The primary objectives of the study are: 1. To assess the effect of hydroxychloroquine (HCQ) in reducing SARS-CoV-2 viral shedding by PCR in infected pregnant women with mild symptoms. 2. Read More

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http://dx.doi.org/10.1186/s13063-020-04557-yDOI Listing

GR-C/EBPα-IGF1 axis mediated azithromycin-induced liver developmental toxicity in fetal mice.

Biochem Pharmacol 2020 Jun 29:114130. Epub 2020 Jun 29.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Azithromycin is considered an effective drug to treat the perinatal mycoplasma infection. However, there is a lack of studies on developmental toxicity of azithromycin. In this study, we observed the developmental toxicity of fetal liver induced by prenatal azithromycin exposure (PAE) in mice and explored the potential mechanism. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114130DOI Listing

Acute Fatty Liver Disease of Pregnancy in the Second Trimester.

Case Rep Crit Care 2020 15;2020:6705784. Epub 2020 Jun 15.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100225, Gainesville, FL 32610-0225, USA.

Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically presents in the third trimester. We report a case of a 21-year-old woman with a history of intrauterine fetal demise at 19 weeks' gestation who developed fulminant liver failure 1 week after the fetal demise. She was diagnosed with AFLP as per the Swansea criteria. Read More

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http://dx.doi.org/10.1155/2020/6705784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315284PMC

Pathogenesis of Preeclampsia and Therapeutic Approaches Targeting the Placenta.

Biomolecules 2020 Jun 24;10(6). Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, UMKC School of Medicine, Kansas City, MO 64108, USA.

Preeclampsia (PE) is a serious pregnancy complication, affecting about 5-7% of pregnancies worldwide and is characterized by hypertension and damage to multiple maternal organs, primarily the liver and kidneys. PE usually begins after 20 weeks' gestation and, if left untreated, can lead to serious complications and lifelong disabilities-even death-in both the mother and the infant. As delivery is the only cure for the disease, treatment is primarily focused on the management of blood pressure and other clinical symptoms. Read More

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http://dx.doi.org/10.3390/biom10060953DOI Listing

The effects, underlying mechanism and interactions of dexamethasone exposure during pregnancy on maternal bile acid metabolism.

Toxicol Lett 2020 Jun 26. Epub 2020 Jun 26.

Department of Obstetrics and Gynaecology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang District, Wuhan, 430071, China; Department of Pharmacology, Basic Medical School of Wuhan University, 185 Donghu Road, Wuchang District, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, 185 Donghu Road, Wuchang District, Wuhan, 430071, China. Electronic address:

As important members in steroids related signal pathways, bile acids are very important in regulating substance metabolism and immune homeostasis. However, bile acids are highly cytotoxic, and the excessive accumulation can induce several abnormalities such as cholestatic liver injury. It is known that the bile acid metabolism alters during pregnancy and mostly will not result in pathologies. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.06.011DOI Listing

Review article: chronic liver disease and pregnancy.

Aliment Pharmacol Ther 2020 Jun 29. Epub 2020 Jun 29.

Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.

Background: The prevalence of chronic liver disease in women of child bearing age is increasing, leading to a higher incidence of pregnancy in this cohort. Chronic medical conditions have a significant adverse effect on maternal morbidity and mortality. To date, reviews on this topic have been written either from a hepatology or obstetrics viewpoint, and no specific guidelines are available solely for the management of chronic liver disease in pregnancy. Read More

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http://dx.doi.org/10.1111/apt.15908DOI Listing

Increased risk of hepatotoxicity and temporary drug withdrawal during treatment of active tuberculosis in pregnant women.

Int J Infect Dis 2020 Jun 24. Epub 2020 Jun 24.

Department of Infectious Diseases, Sahlgrenska University Hospital, SE-416 85 Gothenburg, Sweden; Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, P.O Box 480, SE-405 30 Gothenburg, Sweden. Electronic address:

Background: Few studies have focused on treatment of tuberculosis (TB) during pregnancy. The aim of this study was to evaluate the risk of adverse events, particularly liver toxicity in pregnant women during treatment for active TB.

Methods: We conducted a retrospective study on pregnant and age-matched non-pregnant women receiving treatment for active TB at four hospitals Western Sweden between 1992 and 2017. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.069DOI Listing

Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy.

Sci Rep 2020 Jun 25;10(1):10361. Epub 2020 Jun 25.

Division of Women and Children's Health, King's College London, London, United Kingdom.

Perturbations in the intrauterine environment can result in lifelong consequences for metabolic health during postnatal life. Intrahepatic cholestasis of pregnancy (ICP) can predispose offspring to metabolic disease in adulthood, likely due to a combination of the effects of increased bile acids, maternal dyslipidemia and deranged maternal and fetal lipid homeostasis. Whereas ursodeoxycholic acid (UDCA) is a commonly used treatment for ICP, no studies have yet addressed whether it can also prevent the metabolic effects of ICP in the offspring and fetoplacental unit. Read More

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http://dx.doi.org/10.1038/s41598-020-67301-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316783PMC

Liver disease in pregnancy.

Hepatol Res 2020 Jun 24. Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Tokyo, Japan.

Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as preeclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Read More

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http://dx.doi.org/10.1111/hepr.13540DOI Listing

SARS-CoV-2 Infection and the Newborn.

Authors:
Fahri Ovalı

Front Pediatr 2020 22;8:294. Epub 2020 May 22.

Division of Neonatology, Department of Pediatrics, Istanbul Medeniyet University, Istanbul, Turkey.

Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. All the reported cases in pregnant women were in the 2nd or 3rd trimester and only 1% of them developed severe disease. Read More

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http://dx.doi.org/10.3389/fped.2020.00294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256185PMC

Stillbirth in women with diabetes: a retrospective analysis of fetal autopsy reports.

J Matern Fetal Neonatal Med 2020 Jun 21:1-8. Epub 2020 Jun 21.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Diabetes in pregnancy is associated with an increased rate of stillbirth. There are a wide variety of factors that have been implicated including placental insufficiency, hypoxia, hyperinsulinemia and impaired cardiac function. Furthermore, there is evidence that diabetic pregnancies have an increased rate of fetal cardiomyopathy as compared to non-diabetic pregnancies. Read More

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http://dx.doi.org/10.1080/14767058.2020.1779213DOI Listing

COVID-19 and HELLP: Overlapping Clinical Pictures in Two Gravid Patients.

AJP Rep 2020 Apr 18;10(2):e179-e182. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York.

 The impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) on pregnancies is currently under investigation. There is a significant overlap between the clinical findings in novel coronavirus disease 2019 (COVID-19) and hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP).  Patients presented at 22 and 29 weeks of gestation with suspected COVID-19 pneumonia. Read More

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http://dx.doi.org/10.1055/s-0040-1712978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302930PMC

The risk of pregnancy-associated hypertension in women with nonalcoholic fatty liver disease.

Liver Int 2020 Jun 17. Epub 2020 Jun 17.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non-pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy-associated hypertension (HTN) has not been systematically examined. Read More

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http://dx.doi.org/10.1111/liv.14563DOI Listing

Complement-Mediated Disorders in Pregnancy.

Adv Chronic Kidney Dis 2020 Mar;27(2):155-164

Department of Nephrology/Medicine, Jacobi Medical Center at Albert Einstein College of Medicine, Bronx, NY. Electronic address:

Complement-mediated disorders in pregnancy span a large spectrum and have been implicated in all three complement pathways: classical, lectin, and alternative. Our understanding of these disorders in recent years has advanced due to a better understanding of complement regulatory proteins, such as complement factor H, complement factor I, membrane cofactor protein, and thrombomodulin that particularly affect the alternative complement pathway. Enthusiasm in genotyping for mutations that encode these proteins has allowed us to study the presence of genetic variants which may predispose women to develop conditions such as pregnancy-associated hemolytic uremic syndrome (P-aHUS), thrombotic thrombocytopenic purpura, preeclampsia/hemolysis, elevated liver enzymes, low platelets (HELLP), systemic lupus erythematosus/antiphospholipid syndrome, and peripartum cardiomyopathy. Read More

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http://dx.doi.org/10.1053/j.ackd.2020.01.002DOI Listing

Efficacy and safety of telbivudine treatment for the prevention of HBV perinatal transmission.

Medicine (Baltimore) 2020 Jun;99(24):e20583

First-aid Station, Sixth People's Hospital, Qingdao city, Shandong Province, China.

To observe the efficacy of telbivudine in chronic hepatitis B (CHB) women with high viral load during pregnancy and the long-term effects on intelligence, growth, and development of the newborns.A total of 87 patients were included. Forty-two patients received telbivudine orally 600 mg per day and treatment initiated from 12 weeks after gestation until the 12th postpartum week. Read More

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http://dx.doi.org/10.1097/MD.0000000000020583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302680PMC
June 2020
5.723 Impact Factor

Coenzyme Q 10 supplementation: A potential therapeutic option for the treatment of intrahepatic cholestasis of pregnancy.

Eur J Pharmacol 2020 Jun 10;882:173270. Epub 2020 Jun 10.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Argentina. Electronic address:

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disease characterized by pruritus, elevated serum bile acids and abnormal liver function that may be associated with severe adverse pregnancy outcomes. We previously reported that plasma coenzyme Q10 (CoQ10) is decreased in women with ICP as it is its analogue coenzyme Q9 (CoQ9) in rats with ethinyl estradiol (EE)-induced cholestasis. The aim of the present study was to evaluate the possible therapeutic role of CoQ10 in experimental hepatocellular cholestasis and to compare it with ursodeoxycholic acid (UDCA) supplementation. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173270DOI Listing

Emerging coronaviruses: first SARS, second MERS and third SARS-CoV-2: epidemiological updates of COVID-19.

Infez Med 2020 Jun;28(suppl 1):6-17

Halal Research Center of IRI, FDA, Tehran, Iran.

Since December 2019, the emergence of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection has been reported unexpectedly in Wuhan, China, with staggering infection speed across China and around the world. To date, seven known strains of HCoVs belonging to four genera (i.e. Read More

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[HELLP Syndrome: clinical-analytical characteristics and evolution observed in two years of experience].

Hipertens Riesgo Vasc 2020 Jun 9. Epub 2020 Jun 9.

Servicio de Obstetricia, Hospital Escuela Eva Perón, Santa Fe, Argentina.

Introduction: HELLP syndrome (H: hemolysis, EL: elevated liver enzymes and LP: low platelets) is a form of severe preeclampsia (PE). The syndrome can be: complete or incomplete (with three analytical criteria, or only one or two); Class i, ii or iii (according platelets < 50,000; 50,000-100,000 or > 100,000/mm); postpartum or antepartum; with early or late installation (before or after the 34nd week of gestation). We describe and analyze characteristics and evolution observed in hypertensive pregnant patients who developed HELLP. Read More

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http://dx.doi.org/10.1016/j.hipert.2020.05.003DOI Listing

Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II).

Trials 2020 Jun 12;21(1):520. Epub 2020 Jun 12.

Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, Hubei, China.

Objectives: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.

Trial Design: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.

Participants: Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Read More

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http://dx.doi.org/10.1186/s13063-020-04380-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290137PMC
June 2020
2.117 Impact Factor

Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.

J Hepatol 2020 Apr 15. Epub 2020 Apr 15.

University of California, San Francisco, Department of Obstetrics and Gynecology; University of Southern California, Division of GI/Hepatology. Electronic address:

Aims & Background: Non-alcoholic fatty liver disease (NAFLD) is rising in young adults, with potential implications for reproductive-aged women. Whether NAFLD during pregnancy confers more serious risks for maternal or perinatal health is unclear.

Methods: Using weighted discharge data from the United States National Inpatient Sample, we evaluated temporal trends of NAFLD in pregnancies after 20 weeks gestation, and compared outcomes to pregnancies with other chronic liver diseases (CLD) or no CLD. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.03.049DOI Listing
April 2020
11.336 Impact Factor

Perinatal and infant outcome in prenatally diagnosed hyperechogenic kidneys.

Ultrasound Obstet Gynecol 2020 Jun 12. Epub 2020 Jun 12.

Nephro-Urology Group, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health.

Objective: Hyperechogenic kidneys are a relatively rare antenatal finding, but they generate significant parental anxiety due to uncertain prognosis. We report perinatal and infant outcomes in a large cohort of fetuses with antenatal hyperechogenic kidneys.

Methods: All cases diagnosed prenatally between 2002 and 2017 with hyperechogenic kidneys were assessed in a large tertiary fetal medicine unit. Read More

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http://dx.doi.org/10.1002/uog.22121DOI Listing

Acute Liver Failure During Pregnancy: Happy to Recover from Hep E.

Dig Dis Sci 2020 Jun 10. Epub 2020 Jun 10.

Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s10620-020-06367-3DOI Listing

Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 10;21(1):513. Epub 2020 Jun 10.

Section of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital University of Copenhagen, Hellerup, Denmark.

Objectives: The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as "days alive and out of hospital" as the primary outcome), reduce the risk of non- invasive ventilation, treatment in the intensive care unit and death.

Trial Design: This is a multi-centre, randomised, Placebo-controlled, 2-arm ratio 1:1, parallel group double-blind study.

Participants: 226 participants are recruited at the trial sites/hospitals, where the study will take place in Denmark: Aalborg, Bispebjerg, Gentofte, Herlev, Hillerød, Hvidovre, Odense and Slagelse hospitals. Read More

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http://dx.doi.org/10.1186/s13063-020-04409-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284668PMC

Hepatitis E virus infection during pregnancy.

Virol J 2020 06 10;17(1):73. Epub 2020 Jun 10.

Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, People's Republic of China.

Background: Hepatitis E virus (HEV) generally causes self-limiting viral hepatitis. However, in pregnant women, HEV infection can be severe and has been associated with up to 30% mortality in the third trimester. Additionally, HEV infection in pregnancy is also associated with high rates of preterm labor and vertical transmission. Read More

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http://dx.doi.org/10.1186/s12985-020-01343-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286216PMC

Bilateral anophthalmia and intrahepatic biliary atresia, two unusual components of Fraser syndrome: a case report.

BMC Pregnancy Childbirth 2020 Jun 10;20(1):358. Epub 2020 Jun 10.

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria.

Background: Fraser syndrome or "cryptophthalmos syndrome" is a rare autosomal recessive disease. It is characterized by a group of congenital malformations such as: crytophthalmos, syndactyly, abnormal genitalia, and malformations of the nose, ears, and larynx. Although cryptophthalmos is considered as a main feature of Fraser syndrome, its absence does not exclude the diagnosis. Read More

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http://dx.doi.org/10.1186/s12884-020-03048-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288532PMC

Risk factors assessment in patients with acute fatty liver of pregnancy treated without plasma exchange or renal replacement therapy.

J Matern Fetal Neonatal Med 2020 Jun 10:1-5. Epub 2020 Jun 10.

Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.

Acute fatty liver of pregnancy(AFLP) is a rare but very urgent obstetric disease in clinical. It is a common cause of liver failure in pregnancy and often needs to be admitted to the department of critical care medicine because of the rapid development of acute hepatic dysfunction and severe acute renal dysfunction. The etiology and pathogenesis of this disorder is not very clear although there have been many studies on it before. Read More

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http://dx.doi.org/10.1080/14767058.2020.1777267DOI Listing

Pregnancy Outcomes Following Pediatric Liver Transplantation: A Single-Center Experience in Japan.

Ann Transplant 2020 Jun 9;25:e921193. Epub 2020 Jun 9.

Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.

BACKGROUND The number of pregnancies after liver transplantation (LT) is increasing; however, the safety and incidence of complications associated with these pregnancies are still unclear. In this report, we retrospectively assessed the influences and problems associated with post-transplant pregnancy on allografts, recipients, and fetuses. MATERIAL AND METHODS A total of 14 pregnancies were identified in 8 female recipients between 2005 and 2018. Read More

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http://dx.doi.org/10.12659/AOT.921193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304366PMC

Treatment of rickets and dyslipidemia in twins with progressive familial intrahepatic cholestasis type 2.

Int J Pediatr Endocrinol 2020 26;2020. Epub 2020 May 26.

Connecticut Children's Medical Center, 505 Farmington Avenue, Farmington, CT 06032 USA.

Background: Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2) is a rare congenital cholestatic liver disease that progresses to end stage liver disease. It is associated with fat soluble vitamin D deficiency rickets and severe dyslipidemia; however, treatment of these secondary effects remains a challenge.

Case Presentation: One year old twin males born to a mother with intrahepatic cholestasis during pregnancy presented with jaundice, pruritus and failure to thrive. Read More

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http://dx.doi.org/10.1186/s13633-020-00079-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249403PMC

Correction to: Clinical Practice Guidelines for Childbearing Female Candidates for Bariatric Surgery, Pregnancy, and Post-Partum Management after Bariatric Surgery.

Obes Surg 2020 Jun 5. Epub 2020 Jun 5.

Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Gynecology and Obstetrics, Sorbonne University, Paris, France.

In the original article, due to an XML tagging error the name of Véronique Taillard was omitted from the list of members of the French Study Group for Bariatric Surgery and Maternity (the BARIA-MAT Group). The correct list is as follows. Read More

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http://dx.doi.org/10.1007/s11695-020-04479-3DOI Listing

A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):470. Epub 2020 Jun 3.

Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.

Objectives: SARS-CoV2 infection leads to a concomitant pulmonary inflammation. This inflammation is supposed to be the main driver in the pathogenesis of lung failure (Acute Respiratory Distress Syndrome) in COVID-19. Objective of this study is to evaluate the efficacy and safety of a single dose treatment with Tocilizumab in patients with severe COVID-19. Read More

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http://dx.doi.org/10.1186/s13063-020-04447-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267747PMC

Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):472. Epub 2020 Jun 3.

Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, School of Medicine, University of Cantabria, Av. Valdecilla, 25, 39008, Santander, Cantabria, Spain.

Background: SARS-CoV-2 infection presents a high transmission in the group of health professionals in Spain (12-15% infected). Currently there is no accepted chemoprophylaxis but hydroxychloroquine (HDQ) is known to inhibit the coronavirus in vitro. Our hypothesis is that oral administration of hydroxychloroquine to healthcare professionals can reduce the incidence and prevalence of infection as well as its severity in this group. Read More

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http://dx.doi.org/10.1186/s13063-020-04400-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268173PMC

Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study.

BJOG 2020 Jun 1. Epub 2020 Jun 1.

Maternal-Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objectives: To investigate the incidence of clinical, ultrasonographic and biochemical findings related to pre-eclampsia (PE) in pregnancies with COVID-19, and to assess their accuracy to differentiate between PE and the PE-like features associated with COVID-19.

Design: A prospective, observational study.

Setting: Tertiary referral hospital. Read More

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http://dx.doi.org/10.1111/1471-0528.16339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300912PMC

A Long-term Evaluation of Treatment Results of Pregnant Patients Following a Liver Transplant.

Transplant Proc 2020 May 26. Epub 2020 May 26.

Department of Nephrologic Nursing, Medical University of Warsaw, Warsaw, Poland.

Introduction: Transplantation is not only the best method for treating end-stage failure of many organs but also the way to improve the quality of life of patients. For women of childbearing age, an organ transplant often brings a restoration of regular reproductive functions, which means, among other things, the possibility of having biological offspring.

Objectives: The aim of the study was to analyze the medical records and assess the impact of a liver transplant on the course of pregnancy and labor. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.034DOI Listing

Eupatilin treatment inhibits transforming growth factor beta-induced endometrial fibrosis in vitro.

Clin Exp Reprod Med 2020 Jun 28;47(2):108-113. Epub 2020 May 28.

Department of Biomedical Science, School of Life Science, CHA University, Seongnam, Korea.

Objective: Endometrial fibrosis, the primary pathological feature of intrauterine adhesion, may lead to disruption of endometrial tissue structure, menstrual abnormalities, infertility, and recurrent pregnancy loss. At present, no ideal therapeutic strategy exists for this fibrotic disease. Eupatilin, a major pharmacologically active flavone from Artemisia, has been previously reported to act as a potent inducer of dedifferentiation of fibrotic tissue in the liver and lung. Read More

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http://dx.doi.org/10.5653/cerm.2019.03475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315855PMC

Signalling by lysophosphatidate and its health implications.

Essays Biochem 2020 May 26. Epub 2020 May 26.

Cancer Research Institute of Northern Alberta, Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada.

Extracellular lysophosphatidate (LPA) signalling is regulated by the balance of LPA formation by autotaxin (ATX) versus LPA degradation by lipid phosphate phosphatases (LPP) and by the relative expressions of six G-protein-coupled LPA receptors. These receptors increase cell proliferation, migration, survival and angiogenesis. Acute inflammation produced by tissue damage stimulates ATX production and LPA signalling as a component of wound healing. Read More

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http://dx.doi.org/10.1042/EBC20190088DOI Listing

Hepatitis E virus infection in pregnant women, Argentina.

BMC Infect Dis 2020 May 24;20(1):368. Epub 2020 May 24.

Instituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba (UNC), Enfermera Gordillo Gómez, s/n (without number), X5016, Córdoba, Argentina.

Background: Hepatitis E virus (HEV) infection is an important cause of acute hepatitis worldwide. In pregnant women, HEV can cause more severe symptoms, with high rates of fatal hepatic failure in endemic countries. However, HEV prevalence and circulation among pregnant women from South America is almost unknown. Read More

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http://dx.doi.org/10.1186/s12879-020-05087-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245834PMC

HELLP Syndrome or Acute Fatty Liver of Pregnancy: A Differential Diagnostic Challenge: Common Features and Differences.

Geburtshilfe Frauenheilkd 2020 May 18;80(5):499-507. Epub 2020 May 18.

Frauenklinik, Universitätsklinikum Erlangen, Erlangen, Germany.

HELLP syndrome and the less common acute fatty liver of pregnancy (AFL) are unpredictable, life-threatening complications of pregnancy. The similarities in their clinical and laboratory presentations are often challenging for the obstetrician when making a differential diagnosis. Both diseases are characterised by microvesicular steatosis of varying degrees of severity. Read More

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http://dx.doi.org/10.1055/a-1091-8630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234826PMC

A Comparison of Predictive Performances between Old versus New Criteria in a Risk-Based Screening Strategy for Gestational Diabetes Mellitus.

Diabetes Metab J 2020 Apr 13. Epub 2020 Apr 13.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Background: The definition of the high-risk group for gestational diabetes mellitus (GDM) defined by the American College of Obstetricians and Gynecologists was changed from the criteria composed of five historic/demographic factors (old criteria) to the criteria consisting of 11 factors (new criteria) in 2017. To compare the predictive performances between these two sets of criteria.

Methods: This is a secondary analysis of a large prospective cohort study of non-diabetic Korean women with singleton pregnancies designed to examine the risk of GDM in women with nonalcoholic fatty liver disease. Read More

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http://dx.doi.org/10.4093/dmj.2019.0126DOI Listing

Hepatic steatosis among people living with HIV in Southern Brazil: prevalence and risk factors.

Sci Rep 2020 May 19;10(1):8282. Epub 2020 May 19.

Science Health Institute, Centro Universitário Ritter dos Reis, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Chronic liver disease is an important cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) and is frequently related to non-alcoholic fatty liver disease (NAFLD). The objective is to estimate the prevalence and risk factors of hepatic steatosis among consecutive patients with stable HIV infection on antiretroviral therapy (ART). Also, the use of transient elastography (TE) as a mean to identify a subgroup at risk for non-alcoholic steatohepatitis (NASH) and/or liver fibrosis. Read More

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http://dx.doi.org/10.1038/s41598-020-65133-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237667PMC

Adenosine A receptor antagonists: from caffeine to selective non-xanthines.

Br J Pharmacol 2020 May 18. Epub 2020 May 18.

Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

A long evolution of knowledge of the psychostimulant caffeine led in the 1960s to another purine natural product, adenosine and its A receptor. Adenosine is a short-lived autocrine/paracrine mediator that acts pharmacologically at four different adenosine receptors in a manner opposite to the pan-antagonist caffeine and serves as an endogenous allostatic regulator. Although detrimental in the developing brain, caffeine appears to be cerebroprotective in aging. Read More

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http://dx.doi.org/10.1111/bph.15103DOI Listing
May 2020
4.842 Impact Factor

Euglycemic Ketoacidosis.

Curr Diab Rep 2020 May 19;20(7):25. Epub 2020 May 19.

Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.

Purpose Of Review: Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyperglycemia can delay diagnosis and treatment, resulting in potential serious adverse outcomes. Read More

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http://dx.doi.org/10.1007/s11892-020-01307-xDOI Listing

Response to letter concerning our Pregnancy manuscript.

Hepatology 2020 May 17. Epub 2020 May 17.

University of Texas Southwestern Medical Center, Division of Digestive and Liver Diseases, Columbus, USA.

We agree that timely delivery is the first line of defense; however, as we pointed out, all patients had been delivered prior to enrollment in our study. Post-partum hepatology consultation is multifactorial: the emergent nature of the deliveries, life-threatening status of the patients, and the assumption of improvement leads to postponing Hepatology consultation until it is apparent that liver failure does not resolve. Read More

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http://dx.doi.org/10.1002/hep.31322DOI Listing

International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019.

BMJ Open 2020 May 15;10(5):e035246. Epub 2020 May 15.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

Purpose: The objectives of the International epidemiology databases to evaluate AIDS (IeDEA) are to (i) evaluate the delivery of combination antiretroviral therapy (ART) in children, adolescents and adults in sub-Saharan Africa, (ii) to describe ART regimen effectiveness, durability and tolerability, (iii) to examine HIV-related comorbidities and coinfections and (iv) to examine the pregnancy-related and HIV-related outcomes of women on ART and their infants exposed to HIV or ART in utero or via breast milk.

Participants: IeDEA is organised in four regions (Central, East, Southern and West Africa), with 240 treatment and care sites, six data centres at African, European and US universities, and almost 1.4 million children, adolescents and adult people living with HIV (PLWHIV) enrolled. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232622PMC

The safety of antiviral therapy and drug withdrawal for the prevention of mother-to-child transmission of HBV during pregnancy.

J Med Virol 2020 May 15. Epub 2020 May 15.

Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Background And Aim: The efficacy of prenatal antiviral therapy (AVT) for preventing the vertical transmission of hepatitis B virus (HBV) is well demonstrated. However, data are limited regarding the safety of postpartum cessation of AVT, which may induce alanine aminotransferase (ALT) elevation. We aimed to investigate the necessity of prolonging maternal AVT after delivery. Read More

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http://dx.doi.org/10.1002/jmv.26011DOI Listing
May 2020
2.347 Impact Factor

Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study.

Gynecol Oncol 2020 May 8. Epub 2020 May 8.

New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Objective: To investigate GTN lethality among Brazilian women comparing cases of death by GTN with those who survived, thereby identifying factors associated with GTN lethality.

Methods: We retrospectively reviewed medical records of women with GTN treated at ten Brazilian GTN Reference Centers, from January 1960 to December 2017. We evaluated factors associated with death from GTN and used Cox proportional hazards regression models to identify independent variables with significant influence on the risk of death. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.704DOI Listing

A Proposed Plan for Prenatal Care to Minimize Risks of COVID-19 to Patients and Providers: Focus on Hypertensive Disorders of Pregnancy.

Am J Perinatol 2020 Jun 12;37(8):837-844. Epub 2020 May 12.

Department of Obstetrics, Gynecology, Reproductive Sciences, University of Texas-Houston, Houston, Texas.

Hypertensive disorders are the most common medical complications of pregnancy and a major cause of maternal and perinatal morbidity and death. The detection of elevated blood pressure during pregnancy is one of the cardinal aspects of optimal antenatal care. With the outbreak of novel coronavirus disease 2019 (COVID-19) and the risk for person-to-person spread of the virus, there is a desire to minimize unnecessary visits to health care facilities. Read More

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http://dx.doi.org/10.1055/s-0040-1710538DOI Listing

Hepatitis E.

Authors:
Angel N Desai

JAMA 2020 05;323(18):1862

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http://dx.doi.org/10.1001/jama.2019.21495DOI Listing

Pregnancy outcomes of patients with acute fatty liver of pregnancy: a case control study.

BMC Pregnancy Childbirth 2020 May 11;20(1):282. Epub 2020 May 11.

Department of Obstetrics and Gynecology, Beijing Youan Hospital, Capital Medical University, YouAn outer street No.8, Fengtai District, Beijing, 100006, China.

Background: Limited data exists regarding the pregnancy and infant outcomes of Acute Fatty Liver of Pregnancy (AFLP).

Methods: Retrospectively collected mothers with AFLP and mothers without AFLP in our center from 1/2008 to 6/2018. The primary assessment was to analyze and compare the frequency of negative maternal and fetal outcomes. Read More

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http://dx.doi.org/10.1186/s12884-020-02980-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216501PMC