1,078,500 results match your criteria Liver


[Liver transplantation for polycystic liver disease: 11 cases report and literature review].

Zhonghua Yi Xue Za Zhi 2019 Mar;99(10):767-770

Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

To explore the indications and safety of orthopedic liver transplantation for polycystic liver disease (PLD). Data of 11 patients with PLD who underwent orthotopic liver transplantation between 2004 and 2013 was retrospectively analyzed. Demographic, clinical and follow-up data were collected for statistical analysis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.10.012DOI Listing

[A case report on multiple organ dysfunction syndrome caused by acute carbon tetrachloride poisoning].

Authors:
N Xue Z Li Y J Yan

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):63-65

Shandong Provincial Hospital of Occupational Disease, Jinan 250062, China.

Occupational acute carbon tetrachloride poisoning occurs when a worker is exposed to highly condensed carbon tetrachloride in a short time and suffers from diseases damaging mainly his neutral system and (or) liver and kidney. This article reports a case of what clinical symptoms MODS patients show and how to diagnose, differential diagnosis and therapy process. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.015DOI Listing
January 2019

Establishment of gene-edited pigs expressing human blood coagulation factor VII and albumin for bioartificial liver use.

J Gastroenterol Hepatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University.

Background And Aim: Bioartificial livers (BALs) are considered as a solution to bridge patients with acute liver failure to liver transplantation or to assist in spontaneous recovery for patients with end-stage liver disease. Pig is the best donor of hepatocytes for BALs in clinical trials, because metabolic and detoxification function of its liver are close to human. However, using pig hepatocytes for BALs remains controversial for safety concern owing to nonhuman proteins secretion. Read More

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http://dx.doi.org/10.1111/jgh.14666DOI Listing

Mice Lacking Fatty Acid-Binding Protein 5 Are Resistant to Listeria monocytogenes.

J Innate Immun 2019 Mar 18:1-12. Epub 2019 Mar 18.

To investigate the role of fatty acid-binding protein 5 (FABP5) in infectious diseases, FABP5-deficient mice were challenged with Listeria monocytogenes, a facultative intracellular bacterial pathogen. Interestingly, FABP5-deficient animals were able to clear the infection within 3 days whereas control wild-type (WT) animals showed comparatively higher bacterial burdens in the liver and spleen. Sections of infected tissues showed an increase in inflammatory foci in WT mice compared to FABP5-deficient mice. Read More

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http://dx.doi.org/10.1159/000496405DOI Listing

Production and characterization of extracellular polymeric substances (EPS) generated by a carbofuran degrading strain Cupriavidus sp. ISTL7.

Bioresour Technol 2019 Mar 12;282:417-424. Epub 2019 Mar 12.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India. Electronic address:

The present study demonstrates EPS production by Cupriavidus sp. ISTL7 along with its capability to remediate a toxic carbamate pesticide, carbofuran. The strain ISTL7 efficiently degraded approximately 98% of carbofuran (400 ppm) within 96 h. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.03.054DOI Listing

Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats.

Environ Toxicol Pharmacol 2019 Mar 8;68:109-119. Epub 2019 Mar 8.

Institute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, 230032, Anhui, China. Electronic address:

Di(2-ethylhexyl) phthalate (DEHP) is an environmental pollutant that is widely used in medical and consumer products. An epidemiological study has suggested that a large daily intake of DEHP from phthalate-contaminated food may be a risk factor for liver dysfunction. Long-term exposure to DEHP is associated with liver disease and exacerbates the progression of chronic liver injury. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.008DOI Listing

Low susceptibility of asunaprevir towards R155K and D168A point mutations in HCV NS3/4A protease: A molecular dynamics simulation.

J Mol Graph Model 2019 Mar 11;89:122-130. Epub 2019 Mar 11.

Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand; Ph.D. Program in Bioinformatics and Computational Biology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address:

Hepatitis C has become an important health problem that requires expensive treatment and leads to liver tumorigenesis. Hepatitis C virus (HCV), which is the main cause of hepatitis C, has a high mutation rate due to the lack of proofreading activity of the RNA polymerase enzyme. The NS3/4A serine protease is an important target for anti-HCV drug discovery and development because of its crucial role in the cleavage of the polypeptides involved in viral replication. Read More

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http://dx.doi.org/10.1016/j.jmgm.2019.03.006DOI Listing

Expanding Hydrophobically Modified Chitosan Foam for Internal Surgical Hemostasis: Safety Evaluation in a Murine Model.

J Surg Res 2019 Mar 15;239:269-277. Epub 2019 Mar 15.

Regenerative Bioscience Center, University of Georgia, Athens, Georgia. Electronic address:

Background: A novel injectable expanding foam based on hydrophobically modified chitosan (HM-CS) was developed to improve hemostasis during surgeries. HM-CS is an amphiphilic derivative of the natural biopolymer chitosan (CS); HM-CS has been shown to improve the natural hemostatic characteristics of CS, but its internal safety has not been systematically evaluated. The goal of this study was to compare the long-term in vivo safety of HM-CS relative to a commonly used fibrin sealant (FS), TISSEEL (Baxter). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.060DOI Listing

Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet.

J Nutr Biochem 2019 Feb 19;67:111-122. Epub 2019 Feb 19.

Department and Institute of Pharmacology, National Defense Medical Center, Taipei. Electronic address:

Estrogen deficiency in postmenopausal women is linked to the higher prevalence of obesity, type 2 diabetes and metabolic syndromes. Development of beige adipocytes (browning of WAT) increases energy expenditure and could be a promising strategy for obesity management. This study aimed to investigate the effects of phytoestrogen genistein (GEN) on white adipose tissue (WAT) inflammation, browning and hepatic lipogenesis in ovariectomized rats with high-fat diet (HFD) and further explore the underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.02.001DOI Listing
February 2019

Multi-targeted approach by 2-benzimidazolylquinoxalines-loaded cationic arginine liposomes against сervical cancer cells in vitro.

Colloids Surf B Biointerfaces 2019 Mar 12;178:317-328. Epub 2019 Mar 12.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan, 420088, Russian Federation.

Multi-targeted approaches for inhibition of сervical cancer cells in vitro were developed by implementing two different strategies and drug combination for creation of new therapeutic target agents and for nanotechnological-enhancement of intracellular delivery. New 2-benzimidazolylquinoxalines derivatives were synthesized and characterized by combining two different pharmacophores - benzimidazole and quinoxaline rings directly bonded in their structures. Spectrophotometric technique for determination of content of compounds in various media was developed to evaluate their solubility in water and micellar solutions of surfactants. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.021DOI Listing

Pharmacokinetics and tissue distribution of Ebracteolatain A, a potential anti-cancer compound, as determined by an optimized ultra-performance liquid chromatography tandem mass spectrometry method.

J Pharm Biomed Anal 2019 Mar 9;169:279-287. Epub 2019 Mar 9.

Department of Pharmacy, Shanghai Baoshan Luodian Hospital, Shanghai, China. Electronic address:

Ebracteolatain A is a phloroglucinol derivative from the root of Euphorbia ebracteolata Hayata, a Traditional Chinese Medicine also known as Langdu. It has been shown to have good inhibitory effects in breast cancer cells. In this study, a simple, rapid, sensitive, and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to study the pharmacokinetics (PKs) and tissue distribution of Ebracteolatain A in rats. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.015DOI Listing

Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions.

J Pharm Biomed Anal 2019 Mar 9;169:269-278. Epub 2019 Mar 9.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza St. 11/12, Gdańsk, 80-233, Poland. Electronic address:

The metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray ionization mass spectrometry (ESI-MS). Simulation of the oxidative phase I metabolism of the compound was achieved in a simple electrochemical thin-layer cell consisting of three electrodes (ROXY, Antec Leyden, the Netherlands). Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.017DOI Listing

A multibiomarker approach for evaluating environmental contamination: Common carp (Cyprinus carpio) transplanted along a gradient of metal pollution.

Sci Total Environ 2019 Mar 4;669:481-492. Epub 2019 Mar 4.

University of Antwerp, Department of Biology, Groenenborgerlaan 171, 2020 Antwerp, Belgium.

Environmental monitoring and risk assessment approaches which include a more holistic view on the effects of pollutants on biota are increasingly sought by regulators and policy makers. Therefore, caged carp juveniles (Cyprinus carpio) were transplanted for 7 weeks along a known Cd and Zn pollution gradient. Metal (Cu, Cd and Zn) accumulation in gill and liver tissue and effect biomarkers (growth, condition factor (CF), hepatosomatic index (HSI), oxygen consumption, swimming capacity, Na/K-ATPase activity (NKA) and metallothionein (MT) levels) were compared. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.028DOI Listing

Blood and bone lead levels in South Africa's Gyps vultures: Risk to nest-bound chicks and comparison with other avian taxa.

Sci Total Environ 2019 Mar 9;669:471-480. Epub 2019 Mar 9.

DST-NRF Centre of Excellence at the FitzPatrick Institute, Department of Zoology and Entomology, University of Pretoria, Private Bag X20, Hatfield, Pretoria 0028, South Africa; National Zoological Garden, South African National Biodiversity Institute, P O Box 754, Pretoria 0001, South Africa. Electronic address:

Poisoning, including secondary lead poisoning, is cited as the single most important cause of vulture mortalities in Africa. To evaluate the prevalence of lead poisoning among South Africa's Gyps vultures compared to other, non-scavenging birds, we obtained blood and bone samples from Cape (Gyps coprotheres) and White-backed (G. africanus) vultures. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.123DOI Listing

Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting.

J Cachexia Sarcopenia Muscle 2019 Mar 18. Epub 2019 Mar 18.

State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.

Background: Muscle wasting occurs in response to various physiological and pathological conditions, including ageing and Duchenne muscular dystrophy (DMD). Transforming growth factor-β1 (TGF-β1) contributes to muscle pathogenesis in elderly people and DMD patients; inhibition of TGF-β1 signalling is a promising therapeutic strategy for muscle-wasting disorders. Hemojuvelin (HJV or Hjv as the murine homologue) is a membrane-bound protein that is highly expressed in skeletal muscle, heart, and liver. Read More

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http://dx.doi.org/10.1002/jcsm.12414DOI Listing

Novel mutations found in the ATP7B gene in Chinese patients with Wilson's disease.

Mol Genet Genomic Med 2019 Mar 18:e649. Epub 2019 Mar 18.

Interventional Center for Oncology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.

Background: Wilson's disease (WD) is an autosomal recessive genetic disease caused by mutations in ATP7B and characterized by copper metabolism disorders.

Methods: Direct sequencing of the ATP7B gene is the most sensitive and widely used confirmatory testing method. Fourteen probands with WD and 12 family members participated in this study. Read More

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http://dx.doi.org/10.1002/mgg3.649DOI Listing

The Range and Reproducibility of the Liver Frailty Index.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, University of California-San Francisco, San Francisco, CA.

The Liver Frailty Index (LFI), composed of three performance-based tests (grip strength, chair stands, balance), is a tool specifically developed in patients with cirrhosis to objectively measure physical function, a critical determinant of health outcomes. We aimed to: 1) determine the range of LFI scores in adults with chronic liver disease but without cirrhosis, 2) determine the range of LFI scores in adults without known liver disease, and 3) evaluate reproducibility of the LFI in adults with cirrhosis listed for liver transplantation. Intraclass correlation coefficient (ICC) assessed inter-rater reliability of the LFI. Read More

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http://dx.doi.org/10.1002/lt.25449DOI Listing

Predictors of De Novo Nonalcoholic Fatty Liver Disease After Liver Transplantation: many unanswered questions.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Medanta Institute of Liver Transplantation and Regenerative medicine, Medanta The Medicity, Gurugram, India.

Post transplant non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) is very common. The progression of fibrosis is accelerated in these patients as compared to NASH in general population. A meta-analysis including 2166 patients showed a 26% pooled prevalence of de novo NAFLD. Read More

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http://dx.doi.org/10.1002/lt.25450DOI Listing

Incidence, clinical features, and outcomes of food allergy in children who underwent liver transplant: 16-year experience.

Pediatr Transplant 2019 Mar 18:e13399. Epub 2019 Mar 18.

Department of General Surgery and Transplant Surgery, Başkent University Hospital, Ankara, Turkey.

Food allergies often develop after liver transplant, especially in young children. However, data are scarce on clinical characteristics and patient outcomes. When we evaluated our pediatric liver transplant patients over a 16-year period, food allergy incidence was 8% (19/236 patients). Read More

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http://dx.doi.org/10.1111/petr.13399DOI Listing

Impact of direct-acting antivirals for hepatitis C virus therapy on tacrolimus dosing in liver transplant recipients.

Transpl Infect Dis 2019 Mar 18:e13078. Epub 2019 Mar 18.

Department of Pharmacy, Michigan Medicine, Ann Arbor, MI, United States.

Introduction: Direct-acting antivirals (DAAs) have transformed hepatitis C virus (HCV) management post-liver transplant. As HCV clears during DAA treatment, hepatic metabolism improves, resulting in decreased tacrolimus concentrations that may require dose adjustment. The purpose of this study was to determine appropriate management of immunosuppression in liver transplant recipients during and following treatment of HCV. Read More

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http://dx.doi.org/10.1111/tid.13078DOI Listing

Skeletal muscle volume loss during transarterial chemoembolization predicts poor prognosis in patients with hepatocellular carcinoma.

Hepatol Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Aim: Sarcopenia has a negative impact on the prognosis of patients with hepatocellular carcinoma (HCC). We investigated the significance of skeletal muscle volume and its changes in HCC patients receiving transarterial chemoembolization (TACE).

Methods: We retrospectively analyzed 179 HCC patients receiving TACE from 2006 to 2017. Read More

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http://dx.doi.org/10.1111/hepr.13331DOI Listing

Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis.

Dev Dyn 2019 Mar 18. Epub 2019 Mar 18.

Center for Reproductive Medicine, Shandong University, Jinan, Shandong 250012, China.

Background: The DENND1A has been identified as a guanine nucleotide exchange factor (GEF) for small GTPase Rab35, which functions in endocytic trafficking to mediate the recycling of selective cargos. Genetic alterations within the DENND1A gene have been implicated in human disease such as polycystic ovary syndrome (PCOS). However, the role of DENND1A in developmental and reproductive processes is largely unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.28
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http://dx.doi.org/10.1002/dvdy.28DOI Listing
March 2019
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Liver fibrosis markers as assessed by ultrasound elastography and serum samples: A large comparative study in hepatitis virus B and C liver diseases.

Hepatol Res 2019 Mar 18. Epub 2019 Mar 18.

Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Purposes: We aimed to compare the well-established liver fibrosis (LF) markers in Japanese patients with chronic hepatitis B (CHB, n=331) and chronic hepatitis C (CHC, n=886) and to discuss possible causes of differences in results between CHB patients and CHC patients.

Methods: Virtual touch quantification (VTQ) in acoustic radiation force impulse, Fib-4 index, aspartate aminotransferase to platelet ratio index (APRI) and hyaluronic acid (HA) were compared between the two cohorts. As an additional investigation, total collagen proportional area (TCPA, %) was tested using liver pathological samples (n=83). Read More

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http://dx.doi.org/10.1111/hepr.13332DOI Listing

Ammonium tetrathiomolybdate treatment of copper-associated hepatopathy in dogs.

J Vet Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Background: Copper-associated hepatopathy (CAH) is a common cause of liver disease in dogs. Although d-penicillamine can be an effective treatment, some dogs fail treatment or develop adverse effects. Ammonium tetrathiomolybdate (TTM) has been used to treat pathologic copper accumulation in other species, but its therapeutic potential for CAH is unknown. Read More

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http://dx.doi.org/10.1111/jvim.15474DOI Listing

Late-evening snacking improves liver functions in patients with liver cirrhosis: A meta-analysis of randomized controlled trials.

J Gastroenterol Hepatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background And Aim: Reduce post-absorptive (fasting) phase by eating late-evening snacks (LES) is a potential intervention to improve substrate utilization and reverse sarcopenia. This study analyzed the results of published randomized control and controlled clinical trials to evaluate the effects of LES on liver function of patients with cirrhosis.

Methods: A meta-analysis was conducted. Read More

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http://dx.doi.org/10.1111/jgh.14665DOI Listing

A Novel Berberine - Metformin Hybrid Compound Exerts Therapeutic Effects on Obese Type 2 Diabetic Rats.

Clin Exp Pharmacol Physiol 2019 Mar 18. Epub 2019 Mar 18.

Academy of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P. R. China.

In this study, we investigated the biological activities of a novel berberine - metformin hybrid compound (BMH473) as an anti - diabetic agent. BMH473 exhibited significant anti - hyperglycemic and anti - hyperlipidemic effects on T2DM rats. In white adipose tissue, BMH473 reduced the perirenal and epididymal adipose tissue mass and modulated the lesions in perirenal adipose tissue, by inhibiting the protein expressions of PPAR - Ɣ, C / EBP - α and SREBP - 1c as well as the mRNA expressions of lipogenic genes. Read More

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http://dx.doi.org/10.1111/1440-1681.13085DOI Listing

Rebaudioside A administration prevents experimental liver fibrosis: an in vivo and in vitro study of the mechanisms of action involved.

J Appl Toxicol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pharmacology, Cinvestav-IPN, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, 07360, Apartado Postal 14-740, Mexico City, Mexico.

Rebaudioside A (Reb A) is a diterpenoid isolated from the leaves of Stevia rebaudiana (Bertoni) that has been shown to possess pharmacological activity, including anti-inflammatory and antioxidant properties. However, the ability of Reb A to prevent liver injury has not been evaluated. Therefore, we aimed to study the potential of Reb A (20 mg/kg; two times daily intraperitoneally) to prevent liver injury induced by thioacetamide (TAA) administration (200 mg/kg; three times per week intraperitoneally). Read More

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http://dx.doi.org/10.1002/jat.3797DOI Listing

Will vitamin E be the hope of patients with NASH and advanced fibrosis? - the reliability is worth discussing.

Authors:
He Jian Leng Ai-Min

Hepatology 2019 Mar 18. Epub 2019 Mar 18.

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.

According to the article conducted by Eduardo et al.(1), the non-transplant survival rate of nonalcoholic steatohepatitis (NASH) patients with bridging necrosis and cirrhosis, which is a subtype of non-alcoholic fatty liver disease (NAFLD), was found to be improved by vitamin E, who will reduce the occurrence of liver decompensation. However, combined with the literature we have reviewed and the clinical experience we have achieved, two important factors that may affect the study results will be proposed in the article. Read More

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http://dx.doi.org/10.1002/hep.30603DOI Listing

A rapid and sensitive UHPLC-MS/MS method for the determination of celosin A in rat plasma with application to pharmacokinetic study.

Biomed Chromatogr 2019 Mar 18:e4535. Epub 2019 Mar 18.

Department of medical affairs, The Fifth People's Hospital of Shanghai, Shanghai, China.

Celosin A (CA), a natural compound isolated from Celosia argentea L., has been shown significant hepatoprotective effect on AHNP-induced liver injury. This study described a rapid and sensitive ultra high pressure liquid chromatography-tandem mass spectrometry (UHPLC- MS/MS) assay for determining of CA in rat plasma. Read More

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http://dx.doi.org/10.1002/bmc.4535DOI Listing

Bile ductular reactions in the liver: similarities are only skin deep.

J Pathol 2019 Mar 18. Epub 2019 Mar 18.

Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Extensive bile ductular reactions (DRs) accompany many cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis (PSC) as well as parenchymal liver cell diseases such as alcoholic liver disease, non-alcoholic steatohepatitis and HCV and HBV infections. DRs originate from bile ducts or hepatocytes after damage and can be identified by expression of markers associated with cholangiocytes, often being associated with disease progression and fibrosis. In a recent issue of The Journal of Pathology, Govaere et al employed high-throughput RNA sequencing to compare the transcriptomic profiles of DR cells from liver diseases of different aetiology; HCV infection affecting hepatocytes and PSC initially affecting biliary epithelial cells. Read More

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http://dx.doi.org/10.1002/path.5265DOI Listing

IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer.

J Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland.

Recent studies suggests that clear cell renal cell carcinoma ccRCC possesses a rare population of cancer stem cells (CSCs) that might contribute to tumor heterogeneity, metastasis and therapeutic resistance. Nevertheless, their relevance for renal cancer is still unclear. In this study, we successfully isolated CSCs from established human ccRCC cell lines. Read More

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http://dx.doi.org/10.1002/path.5267DOI Listing

Challenging metabolic tissues with fructose: Tissue-specific and sex-specific responses.

J Physiol 2019 Mar 18. Epub 2019 Mar 18.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford.

Excessive consumption of free sugars (which typically includes a composite of glucose and fructose) is associated with an increased risk of developing chronic metabolic diseases including obesity, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and cardiovascular disease. Determining the utilisation, storage and fate of dietary sugars in metabolically relevant tissues is fundamental to understanding their contribution to metabolic disease risk. To date, the study of fructose metabolism has primarily focussed on the liver, where it has been implicated in impaired insulin sensitivity, increased fat accumulation and dyslipidaemia. Read More

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http://dx.doi.org/10.1113/JP277115DOI Listing

Optimized protocol for the hepatic differentiation of iPSCs in a fluidic microenvironment.

Biotechnol Bioeng 2019 Mar 18. Epub 2019 Mar 18.

CNRS UMI 2820; Laboratory for Integrated Micro Mechatronic Systems, Institute of Industrial Science, the University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan.

In the present study, we evaluated the performance of different protocols for the hepatic differentiation of hiPSCs in microfluidic biochips. Strategies for complete and partial on-chip differentiation were tested. Unlike full on-chip differentiation, the transfer of iPSCs from Petri dishes to biochips during the differentiation process produced a heterogeneous tissue with enhanced hepatic features compared to control cultures in Petri dishes. Read More

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http://dx.doi.org/10.1002/bit.26970DOI Listing

Evidence of bromethalin toxicosis in feral San Francisco "Telegraph Hill" conures.

PLoS One 2019 18;14(3):e0213248. Epub 2019 Mar 18.

Infectious Diseases Laboratory, University of Georgia, Athens, Georgia, United States of America.

During 2018, four free-ranging conures, from a naturalized flock in San Francisco, presented with a characteristic set of neurologic signs that had been reported in other individuals from this flock. The cause of morbidity or mortality in historic cases has not been identified. From these four subjects, fresh feces were collected during their initial days of hospitalization and submitted to the University of Georgia Infectious Diseases Laboratory and Center for Applied Isotope Studies for bromethalin and desmethyl-bromethalin quantitation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213248PLOS

Biomarkers of Drug-Induced Liver Toxicity.

Authors:
Manuela G Neuman

Ther Drug Monit 2019 Apr;41(2):227-234

In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Drug-induced liver injury (DILI) is a comprehensive phenomenon. The injury to the liver may occur as an unexpected and undesired reaction to a therapeutic dose of a drug (idiosyncratic reaction) or as an expected therapeutic effect of the direct (intrinsic) toxicity of a drug taken in a large enough dose to cause liver injury. The direct toxicity (type A) reactions represent an extension of the drug's therapeutic effect; they occur relatively frequently and are typically dose-related and frequency-of-exposure-related. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000610DOI Listing

Biomarkers of Drug-Induced Kidney Toxicity.

Ther Drug Monit 2019 Apr;41(2):213-226

Division of Renal Diseases and Hypertension, University of Colorado at Denver, Aurora, Colorado.

Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because they are influenced by many renal and nonrenal factors independent of kidney function. A biomarker that is released directly into the blood or urine by the kidney in response to injury may be a better early marker of drug-induced kidney toxicity than blood urea nitrogen and serum creatinine. Urine albumin and urine protein, as well as urinary markers kidney injury molecule-1 (KIM-1), β2-microglobulin (B2M), cystatin C, clusterin, and trefoil factor-3 (TFF-3) have been accepted by the Food and Drug Administration and European Medicines Agency as highly sensitive and specific urinary biomarkers to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000589DOI Listing

Multiomics-based strategies for taming intestinal inflammation in the neonate.

Authors:
Josef Neu

Curr Opin Clin Nutr Metab Care 2019 Mar 14. Epub 2019 Mar 14.

Department of Pediatrics/Neonatology, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: The purpose of this review is to discuss evolving research into intestinal inflammatory responses as they relate to the developing microbiome and to provide insights into developing multiomic tools that are being used to describe these relationships. Intestinal inflammatory conditions are common, and in the neonate present special challenges, especially in the form of necrotizing enterocolitis (NEC) and other conditions that involve damage or breakdown of the mucosal barrier, leading to systemic inflammation and damage to distal sites, such as the liver and brain.

Recent Studies: Recent studies show that when a dysbiosis (microbial imbalance or impaired microbiota) occurs, an inflammatory response that can affect the entire body is frequently the result. Read More

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http://dx.doi.org/10.1097/MCO.0000000000000559DOI Listing

Successful Resuscitation Using Extracorporeal Membrane Oxygenation of 2 Patients With Severe Liver Rupture: A Case Report.

A A Pract 2019 Mar 14. Epub 2019 Mar 14.

Anesthesiology and Critical Care Medicine.

Extracorporeal membrane oxygenation is a rescue treatment for respiratory or cardiac failure. Its use is limited in patients predisposed to bleeding due to heparin administration. We present 2 patients with deranged coagulation after liver rupture successfully treated by extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000996DOI Listing

Serum Proteomic Changes as Candidate Biomarkers of Intermediate Liver Fibrosis in Chronic Hepatitis B Infection.

OMICS 2019 Mar;23(3):167-179

1 Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Chronic hepatitis B (CHB) is a major global health burden. Liver fibrosis, an insidious process, is the main histopathological change in CHB that might lead to the end-stage liver disease if left untreated. The intermediate liver fibrosis (S2) is the optimal time to start antiviral therapy. Read More

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http://dx.doi.org/10.1089/omi.2018.0179DOI Listing

Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression.

Mol Pharm 2019 Mar 18. Epub 2019 Mar 18.

C-X-C chemokine receptor type 4 (CXCR4) is a protein that in humans is encoded by the CXCR4 gene and binds the ligand CXCL12 (also known as SDF-1). The CXCR4-CXCL12 interaction in cancer elicits biological activities that result in tumor progression and has accordingly been the subject of significant investigation for detection and treatment of disease. Peptidic antagonists have been labeled with a variety of radioisotopes for detection of CXCR4, but methodology utilizing small molecules have predominantly used radiometals. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00069DOI Listing

Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model.

ACS Nano 2019 Mar 18. Epub 2019 Mar 18.

Department of Pharmaceutical and Pharmacological Sciences , University of Padova , Padova , 35131 , Italy.

Steroids are the standard therapy for autoimmune hepatitis (AIH) but the long-lasting administration is hampered by severe side effects. Methods to improve the tropism of the drug toward the liver are therefore required. Among them, conjugation to nanoparticles represents one possible strategy. Read More

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http://dx.doi.org/10.1021/acsnano.8b09655DOI Listing

Rutin as Deoxyribonuclease I Inhibitor.

Chem Biodivers 2019 Mar 18. Epub 2019 Mar 18.

Faculty of Medicine, University of Nis, Department of Chemistry, Bulevar Dr Zorana Djindjica 81, 18000, Nis, SERBIA.

DNase I inhibitory potential of water extract of nine Hypericum species (H. umbellatum, H. barbatum, H. Read More

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http://dx.doi.org/10.1002/cbdv.201900069DOI Listing

Anatomical, histomorphological, and molecular classification of cholangiocarcinoma.

Liver Int 2019 Mar 18. Epub 2019 Mar 18.

Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome "Foro Italico", Rome, Italy.

Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and distal based on its anatomical location. Histologically, conventional perihilar/distal cholangiocarcinomas are mucin-producing adenocarcinomas or papillary tumors; intrahepatic cholangiocarcinomas are more heterogeneous and can be sub-classified according to the level or size of the displayed bile duct. Read More

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http://dx.doi.org/10.1111/liv.14093DOI Listing

Liver Transplantation for Alcoholic Hepatitis is Likely Underestimated in the National Transplant Database.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Department of Gastroenterology, University of California, San Francisco, CA, USA.

Alcohol-associated liver disease can be coded in UNOS as either alcoholic cirrhosis or alcoholic hepatitis (AH), without specific criteria to assign either diagnosis. In this multi-center ACCELERATE-AH study, we sought to assess the concordance of clinician-diagnosis of AH at LT listing versus UNOS data-entry of AH as listing diagnosis. In a prior study, consecutive early LT recipients for AH between 2012-2017 were identified by chart review at 10 ACCELERATE-AH sites. Read More

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http://dx.doi.org/10.1002/lt.25448DOI Listing

Vascular Remodeling of Visceral Arteries Following Interruption of the Splenic Artery During Liver Transplantation.

Liver Transpl 2019 Mar 18. Epub 2019 Mar 18.

Liver Transplant Center, General Surgery 2U, University of Torino; A.O.U. Città della Salute e della Scienza, Torino, Italy.

Splenic artery (SA) ligation can be performed during liver transplantation (LT) to avoid portal hyperperfusion, which is involved in the pathogenesis of both small-for-size and splenic artery syndrome. Splenic artery can also be used as an inflow for arterial reconstruction. Exceptionally, SA interruption or agenesis has been associated with positive remodeling of collateral arteries supplying the spleen via left gastric artery, short gastric vessels and gastroepiploic arcade, with subsequent severe upper gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1002/lt.25447DOI Listing

Delayed Spontaneous Hepatitis C Virus Elimination in a Renal Transplant Patient Following Graft Rejection.

Transpl Infect Dis 2019 Mar 18:e13079. Epub 2019 Mar 18.

Department of Internal Medicine, Section on Infectious Diseases, Wake Forest School of Medicine, Winston Salem, NC.

Following an acute infection, the hepatitis C virus (HCV) can spontaneously clear (in 15-50% of cases) but often evolves to a chronic stage due to an ineffective immunological response . Chronic HCV infection may manifest from mild, asymptomatic liver disease to cirrhosis with development of complications such as liver failure and hepatocellular carcinoma . Spontaneous clearance of chronic HCV infection without antiviral therapy is extremely rare, and the mechanisms involved are not well known. Read More

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http://dx.doi.org/10.1111/tid.13079DOI Listing

Collagen proportionate area is an independent predictor of long-term outcome in patients with non-alcoholic fatty liver disease.

Aliment Pharmacol Ther 2019 Mar 18. Epub 2019 Mar 18.

UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, UK.

Background: Collagen proportionate area (CPA) measurement is a technique that quantifies fibrous tissue in liver biopsies by measuring the amount of collagen deposition as a proportion of the total biopsy area. CPA predicts clinical outcomes in patients with HCV and can sub-classify cirrhosis.

Aims: To test the ability of CPA to quantify fibrosis and predict clinical outcomes in patients with NAFLD. Read More

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http://dx.doi.org/10.1111/apt.15219DOI Listing

IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction.

Histopathology 2019 Mar 18. Epub 2019 Mar 18.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

Aims: To investigate whether genetic or inflammatory pro-oncogenic factors are relevant to the increased risk of gallbladder cancers in patients with pancreaticobiliary maljunction (PBM).

Methods: Mutations in KRAS exon 2 were examined by a highly sensitive, droplet digital PCR platform using surgically resected specimens of PBM-associated (n=31) and non-associated gallbladder cancers (n=49). The tissue expression of IL-6 and IL-33, which are suspected to promote biliary carcinogenesis, was analyzed by quantitative real-time PCR and in situ hybridization. Read More

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http://dx.doi.org/10.1111/his.13863DOI Listing

Metabolomics analysis of the therapeutic mechanism of Semen Descurainiae Oil on hyperlipidemia rats using H-NMR and LC-MS.

Biomed Chromatogr 2019 Mar 18:e4536. Epub 2019 Mar 18.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, China.

Semen descurainiae oil (SDO) is an important traditional Chinese medicine that was discovered to have the function of reducing blood lipid in recent years. Metabolomics approach of plasma, liver and kidney in rats were performed using H-NMR and LC-MS to illuminate the lower blood lipid concentration effect of SDO, and the niacin was considered as active control. The measure of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in plasma showed that SDO treatment decreased significantly the content of TC and LDL-C. Read More

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http://dx.doi.org/10.1002/bmc.4536DOI Listing

Hepatitis C Genotype 4 Virus Nonstructural 3 and Nonstructural 5A Resistance-associated Substitutions in a 16-year-old Adolescent Failing Ombitasvir/Paritaprevir/Ritonavir Plus Ribavirin.

Pediatr Infect Dis J 2019 Apr;38(4):e72-e74

From the Paediatric and Liver Unit, Meyer Children's University Hospital of Florence, Florence, Italy.

Preexistence and appearance of resistance-associated substitutions limit the efficacy of direct-acting antivirals in treatment of hepatitis C. This is the first case report of an adolescent with chronic hepatitis C virus genotype 4 infection and cirrhosis who failed treatment with ombitasvir/paritaprevir/ritonavir and ribavirin. Resistance analysis showed baseline resistance-associated substitutions M28V and Y93C and emergent D168H. Read More

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http://dx.doi.org/10.1097/INF.0000000000002137DOI Listing
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