1,137,788 results match your criteria Liver


Impact of extent of disease on 1-year healthcare costs in patients who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: retrospective observational cohort study.

BJS Open 2020 Jul 11. Epub 2020 Jul 11.

Departments of Surgery, Division of Surgical Oncology, Groningen, the Netherlands.

Background: The goal of this retrospective observational study was to determine the impact of the extent of peritoneal disease on 1-year healthcare costs in patients with colorectal peritoneal metastases (PM) who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). The extent of peritoneal disease, expressed by the Peritoneal Cancer Index (PCI), directly affects the complexity of CRS + HIPEC and ultimately survival outcomes. The impact of the PCI on treatment-related healthcare costs remains unknown. Read More

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http://dx.doi.org/10.1002/bjs5.50320DOI Listing

Protective effect of Lactobacillus salivarius Li01 on thioacetamide-induced acute liver injury and hyperammonaemia.

Microb Biotechnol 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.

The gut microbiota plays pivotal roles in liver disease onset and progression. The protective effects of Lactobacillus salivarius Li01 on liver diseases have been reported. In this study, we aimed to detect the protective effect of L. Read More

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http://dx.doi.org/10.1111/1751-7915.13629DOI Listing

NAFLD is related to Postprandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with postprandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density-lipoproteins (HDL-TG), and subsequent HDL-dysfunction. We assessed liver fat by MR-spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following 3 consecutive meals, in 36 men with type 2 diabetes (T2DM), with the MetS, and controls. Read More

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http://dx.doi.org/10.1111/liv.14597DOI Listing

Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study.

J Hepatobiliary Pancreat Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Pancreatobiliary Cancer Clinic, Gangnam Severance Hospital, Yonsei University College of Medicine, Korea.

Introduction: Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. Read More

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http://dx.doi.org/10.1002/jhbp.801DOI Listing

De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome.

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

Full genome analysis of a young girl with deafness, dystonia, central hypomyelination, refractory seizure, and fluctuating liver function impairment revealed a heterozygous, de novo variant in the BCAP31 gene on chromosome Xq28 (NM_001256447.2:c.92G>A), mutations of which caused the X-linked recessive severe neurologic disorder DDCH (Deafness, Dystonia, and Cerebral Hypomyelination). Read More

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http://dx.doi.org/10.1002/humu.24080DOI Listing

Bilioenteric Reconstruction Techniques in Pediatric Live Donor Liver Transplantation.

Liver Transpl 2020 Jul 11. Epub 2020 Jul 11.

Ege University, Faculty of Medicine, Department of Pediatric Gastroenterology, Izmir, Turkey.

Background: Biliary complications are still a major cause of morbidity following liver transplantation despite the advancements in the surgical technique. While Roux-en-Y hepaticojejunostomy has been the standard technique for years in pediatric cases, there are limited number of reports on the feasibility of duct-to-duct anastomosis with controversial outcomes. With the largest number of patients ever reported on the topic, this study aims to discuss the feasibility of duct-to-duct biliary reconstruction technique in pediatric live donor liver transplantation. Read More

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http://dx.doi.org/10.1002/lt.25845DOI Listing

High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent and nutrition intervention remains the most important therapeutic approach for NAFLD. Our aim was to investigate whether low- (LP) or high-protein (HP) diets are more effective in reducing liver fat and reversing NAFLD and which mechanisms are involved.

Methods: 19 participants with morbid obesity undergoing bariatric surgery were randomized into two hypocaloric (1500-1600 kcal/day) diet groups, a low protein (10E% protein) and a high protein (30E% protein), for three weeks prior to surgery. Read More

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http://dx.doi.org/10.1111/liv.14596DOI Listing

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria.

Sorafenib represents the current standard of care for patients with advanced-stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs frequently during therapy and is accompanied by rapid tumor regrowth after sorafenib therapy termination. To identify the mechanism of this therapy-limiting growth resumption, we established robust sorafenib resistance HCC cell models that exhibited mitochondrial dysfunction and chemotherapeutic crossresistance. Read More

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http://dx.doi.org/10.1096/fj.202001128RDOI Listing

Trends in liver transplantation for chronic hepatitis B in the era of highly potent antiviral therapies over the past two decades.

Liver Transpl 2020 Jul 11. Epub 2020 Jul 11.

The Liver Transplant Center, Queen Mary Hospital, Hong Kong SAR, Hong Kong.

Despite universal neonatal vaccination being implemented in 1988, the prevalence of chronic hepatitis B (CHB) infection remains high in Hong Kong. With antiviral therapy being available for over two decades now, there should be a significant decline in liver-related complications of CHB patients, especially with regards to cirrhosis and decompensated cirrhosis (1). Read More

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http://dx.doi.org/10.1002/lt.25846DOI Listing

MR Elastography-Based Liver Fibrosis Correlates with Liver Events in Nonalcoholic Fatty Liver Patients: A Multi-Center Study.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Fatty Liver Program, Division of Digestive and Liver Diseases, Comprehensive Transplant Program, Cedars-Sinai Medical Center, Los Angeles, California, United States.

Background & Aims: Liver fibrosis assessed by liver biopsy is predictive of clinical liver events in patients with nonalcoholic fatty liver disease (NAFLD). Magnetic resonance elastography (MRE) correlates with liver biopsy in assessing liver fibrosis. However, data assessing the relationship between MRE and clinical liver events are lacking. Read More

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http://dx.doi.org/10.1111/liv.14593DOI Listing

Steroid-sparing maintenance immunosuppression is safe and effective after simultaneous liver kidney transplantation.

Clin Transplant 2020 Jul 11:e14036. Epub 2020 Jul 11.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Optimization of maintenance immunosuppression (mIS) regimens in the transplant recipient requires a balance between sufficient potency to prevent rejection and avoidance of excessive immunosuppression to prevent toxicities and complications. The optimal regimen after simultaneous liver-kidney (SLK) transplantation remains unclear, but small single-center reports have shown success with steroid-sparing regimens. We studied 4184 adult SLK recipients using the Scientific Registry of Transplant Recipients, from 3/1/2002-2/28/2017, on tacrolimus-based regimens at one year post-transplant. Read More

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http://dx.doi.org/10.1111/ctr.14036DOI Listing

Four pathways for hydatid pulmonary embolism.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular and Thoracic Surgery, Sahloul University Hospital, Sousse, Tunisia.

Introduction: Hydatid pulmonary embolism (HPE) is rare but remains an etiology that needs to be considered and kept in mind, especially in endemic areas, as regards nonthrombotic embolism.

Methods: Between 2000 and 2014, 10 patients were treated in our department for the presence of hydatid material in the pulmonary arterial circulation. Through these 10 cases, we try to assess the radioclinical characteristics and results of the surgical treatment. Read More

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http://dx.doi.org/10.1111/jocs.14754DOI Listing

Serum progranulin levels in pediatric patients with Gaucher disease; relation to disease severity and liver stiffness by transient elastography.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Non-invasive screening for liver fibrosis using transient elastography (TE) could be of value in the management of Gaucher disease (GD). Progranulin (PGRN) is a novel disease modifier in GD and an independent marker of liver fibrosis.

Objectives: We determined PGRN levels in pediatric patients with GD and assessed its role as a potential marker for disease severity and relation to liver stiffness by TE. Read More

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http://dx.doi.org/10.1111/liv.14598DOI Listing

Tissue-resident Mucosal-associated invariant T (MAIT) cells in the human kidney represent a functionally distinct subset.

Eur J Immunol 2020 Jul 11. Epub 2020 Jul 11.

Amsterdam UMC, University of Amsterdam, Division of Internal Medicine, Department of Nephrology, Renal Transplant Unit, Amsterdam Infection & Immunity Institute (AI&II), Meibergdreef 9, Amsterdam, The Netherlands.

Mucosal-associated invariant T (MAIT) cells are innate-like T-cells that recognize bacterial riboflavin metabolites. They are present in human blood but are abundant at barrier sites including the liver, lungs, and kidneys, where they possess a CD69 /CD103 tissue-resident phenotype. In renal tissue, MAIT cells likely defend against the ascending uropathogens responsible for urinary tract infections (UTIs), which are common, especially among renal transplant recipients (RTRs). Read More

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http://dx.doi.org/10.1002/eji.202048644DOI Listing

The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters.

Med Phys 2020 Jul 11. Epub 2020 Jul 11.

Division of Quantum Science and Engineering, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido, 0608628, Japan.

Purpose: The purpose of this study is to evaluate the sub-lethal damage (SLD) repair effect in prolonged proton irradiation using the biophysical model with various cell-specific parameters of (α/β) and T (repair half time). At present, most of the model-based studies on protons have focused on acute radiation, neglecting the reduction in biological effectiveness due to SLD repair during the delivery of radiation. Nevertheless, the dose-rate dependency of biological effectiveness may become more important as advanced treatment techniques, such as hypofractionation and respiratory gating, come into clinical practice, as these techniques sometimes require long treatment times. Read More

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http://dx.doi.org/10.1002/mp.14381DOI Listing

Prognostic impact of tumor location in resected gallbladder cancer: A national cohort analysis.

J Surg Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, City of Hope National Medical Center, Duarte, California.

Background And Objectives: Tumor location (peritoneal vs hepatic) has been incorporated in the 8th edition of the American Joint Committee on Cancer Staging system for gallbladder cancer. However, larger studies are needed to confirm the prognostic impact of tumor location.

Methods: Patients with pathologically-confirmed gallbladder cancer with information on primary tumor location were included from the National Cancer Database (2009-2012). Read More

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http://dx.doi.org/10.1002/jso.26107DOI Listing

The peer review at high risk from COVID-19 - are we socially distancing from scientific quality control?

Br J Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Hepatobiliary and Liver Transplant Surgery, St. Vincent's, University Hospital.

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http://dx.doi.org/10.1002/bjs.11785DOI Listing

Splenectomy enhances the Ly6C phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.

Int Immunopharmacol 2020 Jul 7;86:106762. Epub 2020 Jul 7.

National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China; The Liver and Spleen Diseases Research Center, Xi'an, China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, China. Electronic address:

Background And Aim: Splenectomy has been reported to attenuate liver fibrosis. In addition, phenotype transitions of infiltrating macrophages, including Ly6C and Ly6C, play an essential role in the liver fibrosis. However, whether the spleen can regulate the phenotype switch of macrophages and the underlying mechanism still remain unclear. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106762DOI Listing

Identification of monoclonal antibodies suitable for blocking IGF-1 receptors in the horse.

Domest Anim Endocrinol 2020 Jun 17;74:106510. Epub 2020 Jun 17.

School of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address:

Prolonged hyperinsulinemia is thought to be the cause of equine endocrinopathic laminitis, a common and crippling disease of the foot, for which there are no pharmacologic treatments other than pain relief. It has been suggested that insulin causes its effects on the lamellae by activating IGF-1 receptors (IGF-1R), as insulin receptors (InsR) are scarce in this tissue, whereas IGF-1R are abundant and become downregulated after prolonged insulin infusion. As a first step toward confirming this mechanism and beginning to develop a therapeutic anti-IGF-1R monoclonal antibody (mAb) for horses, it was necessary to identify available human IGF-1R mAbs that would recognize equine receptors. Read More

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http://dx.doi.org/10.1016/j.domaniend.2020.106510DOI Listing

Leveraging genetic data to investigate molecular targets and drug repurposing candidates for treating alcohol use disorder and hepatotoxicity.

Drug Alcohol Depend 2020 Jul 2;214:108155. Epub 2020 Jul 2.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, United States; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, United States; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, United States.

Background: Novel treatments for alcohol use disorder (AUD) and alcohol-related liver disease (ALD) are greatly needed. Genetic information can improve drug discovery rates by facilitating the identification of novel biological targets and potential drugs for repurposing.

Methods: The present study utilized a recently developed Bayesian approach, Integrative Risk Gene Selector (iRIGS), to identify additional risk genes for alcohol consumption using SNPs from the largest alcohol consumption GWAS to date (N = 941,280). Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108155DOI Listing

Immature platelets: a review of the available evidence.

Thromb Res 2020 Jul 3;195:43-50. Epub 2020 Jul 3.

Internal Medicine Department, Ibn Sina Hospital, University Mohamed V of Medicine, Rue Lamfadel Cherkaoui, BP 6527 Rabat, Morocco.

Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration. Immature platelet fraction (IPF) represents the percentage of immature circulative platelets to the total number of platelets. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.06.048DOI Listing

Surveillance and Monitoring of Hepatocellular Carcinoma During the COVID-19 Pandemic.

Clin Gastroenterol Hepatol 2020 Jul 8. Epub 2020 Jul 8.

Division of Digestive and Liver Disease, UT Southwestern Medical Center.

The Coronavirus disease 2019 (COVID-19) pandemic is expected to have a long-lasting impact on the approach to care for patients at risk for and with hepatocellular carcinoma (HCC) due to the risks from potential exposure and resource reallocation. The goal of this document is to provide recommendations on HCC surveillance and monitoring, including strategies to limit unnecessary exposure while continuing to provide high-quality care for patients. Publications and guidelines pertaining to the management of HCC during COVID-19 were reviewed for recommendations related to surveillance and monitoring practices, and any available guidance was referenced to support the authors' recommendations when applicable. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.072DOI Listing

Liver resection in Cirrhotic liver: Are there any limits?

Int J Surg 2020 Jul 8. Epub 2020 Jul 8.

Chairman of HPB Surgical Division. Miguel Servet University Hospital. Zaragoza, Spain.

Liver resection remains one of the most technically challenging surgical procedure in abdominal surgery due to the complex anatomical arrangement in the liver and its rich blood supply that constitutes about 20% of the cardiac output per cycle. The challenge for resection in cirrhotic livers is even higher because of the impact of surgical stress and trauma imposed on borderline liver function and the impaired ability for liver regeneration in cirrhotic livers. Nonetheless, evolution and advancement in surgical techniques as well as knowledge in perioperative management of liver resection has led to a substantial improvement in surgical outcome in recent decade. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.050DOI Listing

Laparoscopic Major Liver Resections: Current Standards.

Int J Surg 2020 Jul 8. Epub 2020 Jul 8.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center and Ulsan University, Seoul, Republic of Korea. Electronic address:

Laparoscopic liver resection was slow to be adopted in the surgical arena at the beginning as there were major barriers including the fear of gas embolism, risk of excessive blood loss from the inability to control bleeding vessels effectively, suboptimal surgical instruments to perform major liver resection and the concerns about oncological safety of the procedure. However, it has come a long way since the early 1990s when the first successful laparoscopic liver resection was performed, spurring liver surgeons worldwide to start exploring the roles of laparoscopy in major liver resections. Till date, more than 9000 cases have been reported in the literature and the numbers continue to soar as the hepatobiliary surgical communities quickly learn and apply this technique in performing major liver resection. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.051DOI Listing

An invited commentary on "Feasibility and safety of bisegmentectomy 7-8 while preserving hepatic venous outflow of the right liver - A retrospective cohort study" - increasing resectability rate (Int J Surg 2020;79:273-9).

Int J Surg 2020 Jul 8. Epub 2020 Jul 8.

General and Gastrointestinal (GI) Surgeon, Hospital Das Clínicas, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.ijsu.2020.06.048DOI Listing

Proteomics approaches to understand cell biology and virulence of Entamoeba histolytica protozoan parasite.

J Proteomics 2020 Jul 8:103897. Epub 2020 Jul 8.

Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, CDMX, México. Electronic address:

Entamoeba histolytica is the primitive eukaryotic parasite responsible of human amoebiasis, a disease characterized by bloody intestinal diarrhea and invasive extraintestinal illness. The knowledge of the complete genome sequence of virulent E. histolytica and related non-pathogenic species allowed the development of novel genome-wide methodological approaches including protein expression profiling and cellular proteomics in the so called post-genomic era. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103897DOI Listing

Electrospun Vancomycin-loaded Nanofibers for Management of Methicillin-resistant Staphylococcus aureus-induced Skin Infections.

Int J Pharm 2020 Jul 8:119620. Epub 2020 Jul 8.

Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut 71515, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt; Science Academy, Badr University in Cairo (BUC), Badr City, Cairo 11829 , Egypt. Electronic address:

Skin damage exposes the underlying layers to bacterial invasion, leading to skin and soft tissue infections. Several pathogens have developed resistance against conventional topical antimicrobial treatments and rendered them less effective. Recently, several nanomedical strategies have emerged as a potential approach to improve therapeutic outcomes of treating bacterial skin infections. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119620DOI Listing

Identification of in vitro phase I metabolites of benzotriazole UV stabilizer UV-327 using HPLC coupled with mass spectrometry.

Toxicol In Vitro 2020 Jul 8:104932. Epub 2020 Jul 8.

Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestraße 9-11, 91054 Erlangen, Germany. Electronic address:

The benzotriazole UV stabilizer (BUVS) 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is used in various plastic products to protect them against harmful UV radiation. Meanwhile, there are concerns about potential adverse health effects on humans, as residues of UV-327 and other BUVSs have already been detected in various environmental matrices. However, information on the metabolism of UV-327 is not yet available. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104932DOI Listing

Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease.

Gastroenterology 2020 Jul 8. Epub 2020 Jul 8.

Department of Medicine, University of California San Diego, La Jolla, CA, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA; Center for Innovative Phage Applications and Therapeutics, University of California San Diego, La Jolla, CA, USA. Electronic address:

Background & Aims: Alterations in the gut microbiome have been associated with the severity of nonalcoholic fatty liver disease (NAFLD). These studies focused exclusively on the bacteria in the microbiome; we investigated changes in the viral microbiome (virome) in patients with NAFLD.

Methods: In a prospective, cross-sectional, observational study, we extracted RNA and DNA virus-like particles from fecal samples from 73 patients with NAFLD: 29 patients had a NAFLD activity score (NAS) of 0-4, 44 patients had a NAS of 5-8 or cirrhosis (NAS 5-8/LCI), 37 patients had F0-F1 fibrosis, and 36 patients had F2-F4 fibrosis. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.07.005DOI Listing

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.

Dev Cell 2020 Jul 8. Epub 2020 Jul 8.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

Melanocytes, replenished throughout life by melanocyte stem cells (MSCs), play a critical role in pigmentation and melanoma. Here, we reveal a function for the metastasis-associated phosphatase of regenerating liver 3 (PRL3) in MSC regeneration. We show that PRL3 binds to the RNA helicase DDX21, thereby restricting productive transcription by RNAPII at master transcription factor (MITF)-regulated endolysosomal vesicle genes. Read More

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http://dx.doi.org/10.1016/j.devcel.2020.06.013DOI Listing

Outcomes of surgical coronary revascularization performed pre-solid abdominal organ transplant.

Ann Thorac Surg 2020 Jul 8. Epub 2020 Jul 8.

Division of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

Background: Cardiac risk stratification and coronary angiography are routinely performed as part of kidney and liver transplant candidacy evaluation. There are limited data on the outcomes of surgical coronary revascularization in this patient population. We investigated outcomes in patients with end stage renal or hepatic disease undergoing coronary artery bypass grafting (CABG) to attain kidney or liver transplant candidacy. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.077DOI Listing

A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.

J Nutr 2020 Jul 11. Epub 2020 Jul 11.

Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.

Background: Recent literature suggests that the Western diet's imbalance between high ω-6 (n-6) and low ω-3 (n-3) PUFA intake contributes to fatty liver disease in obese youth.

Objectives: We tested whether 12 wk of a low n-6:n-3 PUFA ratio (4:1) normocaloric diet mitigates fatty liver and whether the patatin-like containing domain phospholipase 3 (PNPLA3) rs738409 variant affects the response.

Methods: In a single-arm unblinded study, obese youth 9-19 y of age with nonalcoholic fatty liver disease were treated with a normocaloric low n-6:n-3 PUFA ratio diet for 12 wk. Read More

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http://dx.doi.org/10.1093/jn/nxaa183DOI Listing

Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids.

J Mol Cell Biol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Weill Cornell Medical College, New York, NY, USA.

Recent advances in development of protocols for directed differentiation from human pluripotent stem cells (hPSCs) to defined lineages, in combination with three-dimensional (3D) organoid technology, have facilitated the generation of various endoderm-derived organoids for in vitro modeling of human gastrointestinal development and associated diseases. In this review, we discuss current state-of-the-art strategies for generating hPSC-derived endodermal organoids including stomach, liver, pancreatic, small intestine, and colonic organoids. We also review the advantages of using this system to model various human diseases and evaluate the shortcomings of this technology. Read More

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http://dx.doi.org/10.1093/jmcb/mjaa031DOI Listing

Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study.

Med Sci Monit 2020 Jul 11;26:e923375. Epub 2020 Jul 11.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Primary hepatic neuroendocrine tumor (PHNET) is a rare primary liver tumor that remains poorly understood. Here, we explored the clinicopathological characteristics and survival outcomes of PHNET patients. MATERIAL AND METHODS PHNET patients diagnosed between 1988 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were enrolled in the cohort. Read More

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http://dx.doi.org/10.12659/MSM.923375DOI Listing

GAMLSS for high-variability data: an application to liver fibrosis case.

Int J Biostat 2020 Jul 13. Epub 2020 Jul 13.

Department in Economics, Business and Statistics (SEAS) University of Palermo Viale delle Scienze, Ed. 13 90128 Palermo, Sicilia, Italy.

This article aims to provide rigorous and convenient statistical models for dealing with high-variability phenomena. The presence of discrepance in variance represents a substantial issue when it is not possible to reduce variability before analysing the data, leading to the possibility to estimate an inadequate model. In this paper, the application of Generalized Additive Model for Location, Scale and Shape (GAMLSS) and the use of finite mixture model for GAMLSS will be proposed as a solution to the problem of overdispersion. Read More

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http://dx.doi.org/10.1515/ijb-2019-0113DOI Listing

Dietary Quercetin Alleviated DSS-induced Colitis in Mice through Several Possible Pathways by Transcriptome Analysis.

Curr Pharm Biotechnol 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Animal Nutrition, College of Animal Science & Technology, China Agricultural University, Beijing. China.

Background: The prevalence of inflammatory bowel disease is rapidly increasing around the world. Quercetin is a flavonoid commonly found in vegetables and fruits and has been reported to exert numerous pharmacological activities such as enhancing antioxidant capacity or suppressing inflammation.

Objective: We aimed to explore whether quercetin was effective for IBD and the underlying mechanism of quercetin for the ameliorative effects on the DSS-induced colitis in mice. Read More

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http://dx.doi.org/10.2174/1389201021666200711152726DOI Listing

Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy.

Intern Emerg Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. Read More

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http://dx.doi.org/10.1007/s11739-020-02425-wDOI Listing

Apixaban Downregulates Endothelial Inflammatory and Prothrombotic Phenotype in an In Vitro Model of Endothelial Dysfunction in Uremia.

Cardiovasc Drugs Ther 2020 Jul 10. Epub 2020 Jul 10.

Pathology Department, CDB, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Purpose: Chronic kidney disease (CKD) associates with inflammatory and prothrombotic phenotypes, resulting in higher cardiovascular risk. Factor Xa displays functions beyond coagulation, exhibiting proinflammatory effects. The aim of the present study was to investigate whether a direct FXa inhibitor protects from the endothelial dysfunction (ED) caused by uremia. Read More

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http://dx.doi.org/10.1007/s10557-020-07010-zDOI Listing

Development of phage delivery by bioencapsulation of artemia nauplii with Edwardsiella tarda phage (ETP-1).

Braz J Microbiol 2020 Jul 10. Epub 2020 Jul 10.

College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon, 34134, Republic of Korea.

This study proposed that phage-enriched artemia could be a useful tool for transferring phage into the cultured fish (larvae or adult) as a feed, and introduce mode of phage administration and its safety in concern of tissue adaptation for efficient phage therapy in aquatic animals. First, whether Edwardsiella tarda phage (ETP-1) could attach or ingest by the artemia and optimum time period for the ETP-1 enrichment with artemia were investigated. ETP-1 dispersion, abundance and persistency, and zebrafish immune transcriptional responses and histopathology were evaluated after feeding the fish with ETP-1-enriched artemia. Read More

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http://dx.doi.org/10.1007/s42770-020-00324-yDOI Listing

Undifferentiated carcinoma of the liver demonstrated by contrast-enhanced ultrasonography.

Clin J Gastroenterol 2020 Jul 10. Epub 2020 Jul 10.

Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-0001, Japan.

A 78-year-old man had received interferon therapy and achieved sustained virologic response for chronic hepatitis C 10 years before. He came to our hospital due to liver damage. Abdominal ultrasonography showed a 90-mm mass lesion in the liver. Read More

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http://dx.doi.org/10.1007/s12328-020-01180-xDOI Listing

Prognostic impact of primary tumor location in Stage III colorectal cancer-right-sided colon versus left-sided colon versus rectum: a nationwide multicenter retrospective study.

J Gastroenterol 2020 Jul 10. Epub 2020 Jul 10.

Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 1040045, Japan.

Background: Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. Read More

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http://dx.doi.org/10.1007/s00535-020-01706-7DOI Listing

Evaluation of the Effect of p-Tyrosol on the Level of DNA Damage in the DNA Comet Assay In Vivo.

Bull Exp Biol Med 2020 Jul 10. Epub 2020 Jul 10.

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia.

The effect of p-tyrosol on the spontaneous level of DNA damage in the cells of the bone marrow, liver, kidney, and rectum of mice (series I) and on the genotoxic effects of cytostatic drugs with different mechanisms of action in rat testicular cells (series II) was studied by DNA comet assay on C57BL/6 mice. p-Tyrosol was administered in a dose of 40 mg/kg once (series I) or for 5 days before and 5 days after cytostatic exposure (busulfan, paclitaxel, methotrexate; series II). It was found that p-tyrosol reduced spontaneous level of DNA damage in all studied organs. Read More

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http://dx.doi.org/10.1007/s10517-020-04857-yDOI Listing

Biosurfactant electrospun nanofibers exhibit minimal side effects on the structure and function of the liver tissue in male rat model.

Environ Sci Pollut Res Int 2020 Jul 10. Epub 2020 Jul 10.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.

Oil spills can result in significant damage to marine estuaries, rivers, lakes, wetlands, and shorelines. Electrospun nanofibers containing biosurfactant (ENFs) can be used to clean oil spills up and protect the environmental biology. Present work aimed to study the side-effects of prepared nanofibers on animal models. Read More

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http://dx.doi.org/10.1007/s11356-020-10077-8DOI Listing

Prediction of zinc phosphide-induced hepatotoxicity and cardiotoxicity from clinical, laboratory, and radiological indicators.

Environ Sci Pollut Res Int 2020 Jul 10. Epub 2020 Jul 10.

Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.

Zinc phosphide (ZnP) is a phosphine-generating pesticide. Serious hepatotoxicity or cardiotoxicity might develop late in initially stable patients. The current prospective study aimed to predict ZnP-induced hepatotoxicity and cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s11356-020-10020-xDOI Listing

The protective effects of Terminalia laxiflora extract on hepato-nephrotoxicity induced by fipronil in male rats.

Environ Sci Pollut Res Int 2020 Jul 10. Epub 2020 Jul 10.

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, P.O.62511, Egypt.

The present study was led to investigate the defensive role of Terminalia laxiflora extract (TLE) on fipronil (FPN) induced hepatotoxicity and nephrotoxicity in male rats. Rats were administered with TLE (100 mg/kg) against the renal toxicity and hepatotoxicity induced by administration of FPN (10.5 mg/kg) for 30 days. Read More

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http://dx.doi.org/10.1007/s11356-020-10018-5DOI Listing

Cirrhotic Cardiomyopathy.

Curr Gastroenterol Rep 2020 Jul 10;22(9):45. Epub 2020 Jul 10.

Liver Unit, University Calgary Cumming School of Medicine, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada.

Purpose Of Review: Cirrhotic cardiomyopathy is a syndrome of depressed cardiac function in patients with cirrhosis. We aimed to review the historical background, pathophysiology and pathogenesis, diagnostic definitions, clinical relevance, and management of this syndrome.

Recent Findings: An inflammatory phenotype underlies the pathogenesis: gut bacterial translocation with endotoxemia stimulates cytokines and cardiodepressant factors, such as nitric oxide and endocannabinoids. Read More

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http://dx.doi.org/10.1007/s11894-020-00783-1DOI Listing

[F]-FDG-PET/CT and [F]-FAZA-PET/CT Hypoxia Imaging of Metastatic Thyroid Cancer: Association with Short-Term Progression After Radioiodine Therapy.

Mol Imaging Biol 2020 Jul 10. Epub 2020 Jul 10.

Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Purpose: To examine the relationships between 2-deoxy-2-[F]fluoro-D-glucose ([F]-FDG) and hypoxia tracer [F]fluoro-azomycinarabinofuranoside ([F]-FAZA) and between I and [F]-FAZA uptake in patients with metastatic thyroid cancer and to evaluate imaging features associated with short-term progression after I therapy.

Procedures: The study population was 20 patients (17 women and 3 men; mean age, 67 years) with metastatic thyroid cancer who underwent both [F]-FDG- and [F]-FAZA-positron emission tomography (PET)/X-ray computed tomography (CT) examinations before I therapy. Short-term response to radioiodine was assessed (mean follow-up, 19 months ± 9). Read More

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http://dx.doi.org/10.1007/s11307-020-01516-6DOI Listing

An Odyssey into the Land of Deleterious Rare Mutations in Colorectal Liver Metastases.

Ann Surg Oncol 2020 Jul 10. Epub 2020 Jul 10.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-020-08820-zDOI Listing
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