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    221 results match your criteria Livedoid Vasculopathy

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    Vasculitic and autoimmune wounds.
    J Vasc Surg Venous Lymphat Disord 2017 Mar 14;5(2):280-292. Epub 2016 Dec 14.
    Division of Rheumatology, The George Washington University, School of Medicine and Health Sciences, Washington, D.C.
    Objective: Chronic wounds are a major cause of morbidity and mortality. Approximately 20% to 23% of nonhealing wounds that are refractory to vascular intervention have other causes, including vasculitis, pyoderma gangrenosum, and other autoimmune diseases. The purpose of this article was to review the literature across medical and surgical specialties with regard to refractory chronic wounds associated with vasculitis and autoimmune diseases and to delineate clinical outcomes of these wounds in response to vascular and other interventions. Read More

    Enhanced mRNA expression of Plasminogen Activator Inhibitor-1 in livedoid vasculopathy lesions.
    Cardiovasc Ther 2017 Feb 10. Epub 2017 Feb 10.
    Department of Medical Biology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
    Aim: Thrombosis and inflammation play an important role in pathophysiology of livedoid vasculopathy (LV). Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of fibrinolysis and is a pivotal modulator in a broad range of biological processes.

    Method: The study specimens were retrospectively selected from archives of pathology department. Read More

    A Case of Streptobacillus moniliformis Infection with Cutaneous Leukocytoclastic Vasculitis.
    Acta Med Okayama 2016 Oct;70(5):377-381
    Department of Dermatology, Okayama City Hospital, Okayama 700-8557,
    A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Read More

    Livedoid vasculopathy - a challenging disease.
    Acta Reumatol Port 2016 Jul-Sep;41(3):273-274
    We present a rare association of idiopathic livedoid vasculopathy (LV) with peripheral sensory neuropathy successfully treated with intravenous immunoglobulin and warfarin and, after its failure, with rituximab. Although LV aetiology remains incompletely understood, the excellent clinical response observed in our patient suggests that B cells may be key players in its pathogenesis. Read More

    Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency.
    J Dermatol 2016 Oct 24. Epub 2016 Oct 24.
    Department of Dermatology, Aichi Medical University, Nagakute, Japan.
    Livedoid vasculopathy (LV) is a chronic disease with recurrent reticularis and ulcers, mainly affecting the feet and lower legs. The pathogenesis of LV has not been yet thoroughly understood, but thrombosis is thought to play a major role because fibrin deposition within both the wall and lumen of affected vessels is pathologically detected. A 68-year-old woman first presented to our hospital in 2004 with a 6-year history of a reticular rash and ulceration on the lower legs. Read More

    Occlusive Nonvasculitic Vasculopathy: A Review.
    Am J Dermatopathol 2016 Oct 18. Epub 2016 Oct 18.
    *Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autónoma, Madrid, Spain; †Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain; ‡Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain; §Dermatopathology Research Unit, Medical University of Graz, Graz, Austria; and ¶Dermatopathologie Laboratory, Friedrichschafen, Germany.
    We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Read More

    Monogenic polyarteritis: the lesson of ADA2 deficiency.
    Pediatr Rheumatol Online J 2016 Sep 8;14(1):51. Epub 2016 Sep 8.
    UO Pediatria II, Istituto G. Gaslini, Genoa, Italy.
    The deficiency of Adenosine Deaminase 2 (DADA2) is a new autoinflammatory disease characterised by an early onset vasculopathy with livedoid skin rash associated with systemic manifestations, CNS involvement and mild immunodeficiency.This condition is secondary to autosomal recessive mutations of CECR1 (Cat Eye Syndrome Chromosome Region 1) gene, mapped to chromosome 22q11.1, that encodes for the enzymatic protein adenosine deaminase 2 (ADA2). Read More

    Persistent cutaneous abdominal ulcerations secondary to diffuse dermal angiomatosis: an underestimated sign for severe atherosclerosis: A case report.
    Medicine (Baltimore) 2016 Jul;95(29):e4212
    aDepartment of Dermatology bDepartment of Vascular Surgery cDepartment of Pathology dDepartment of Infectious Diseases, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Background: Diffuse dermal angiomatosis (DDA) is a rare, acquired, reactive vascular proliferation, clinically characterized by livedoid erythematous-violaceous plaques, which frequently evolve to ulceration and necrosis. Histopathologically, it is manifested by a diffuse proliferation of endothelial cells within the full thickness of the dermis. DDA has been mainly associated with severe peripheral atherosclerosis. Read More

    Livedoid vasculopathy: A review of pathogenesis and principles of management.
    Indian J Dermatol Venereol Leprol 2016 Sep-Oct;82(5):478-88
    Department of Dermatology, Command Hospital, Pune, Maharashtra, India.
    Livedoid vasculopathy is a rare cutaneous disease manifesting as recurrent ulcers on the lower extremities. The ulceration results in atrophic, porcelain white scars termed as atrophie blanche. The pathogenesis is yet to be understood with the main mechanism being hypercoagulability and inflammation playing a secondary role. Read More

    Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment.
    J Am Acad Dermatol 2016 May;74(5):795-804; quiz 805-6
    Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. Inherited conditions tend to present either in neonatal period or later in life, while acquired conditions typically occur later in life. Read More

    Livedoid vasculopathy.
    Rev Bras Reumatol 2016 Feb 17. Epub 2016 Feb 17.
    Serviço de Radiologia, Hospital e Maternidade Celso Pierro, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil.
    Livedoid vasculopathy is a chronic and painful skin disease that progresses to ulceration. Due to its uncertain pathogenesis, there is no single effective treatment for this condition, and current therapeutic options are based on isolated case reports, or on case series. We report a case of a female patient with livedoid vasculopathy, which achieved excellent healing of lower limb ulcers after using an anti-TNF agent. Read More

    Anticoagulation with rivaroxaban for livedoid vasculopathy (RILIVA): a multicentre, single-arm, open-label, phase 2a, proof-of-concept trial.
    Lancet Haematol 2016 Feb 16;3(2):e72-9. Epub 2016 Jan 16.
    Department of Dermatology, University Hospital of Münster, Münster, Germany. Electronic address:
    Background: Livedoid vasculopathy is a thrombotic skin disease characterised by recurrent occlusion of the cutaneous microcirculation in lower extremities, which results in skin infarctions with painful ulcerations and irreversible scar formation. Rivaroxaban is a direct factor Xa inhibitor that prevents thrombus formation. We investigated whether rivaroxaban is effective for the treatment of livedoid vasculopathy. Read More

    Livedoid Vasculopathy with Hyperhomocysteinemia Responding to Hyperbaric Oxygen Therapy.
    Indian J Dermatol 2015 Sep-Oct;60(5):524
    Department of Marine Medicine, INHS Asvini, Mumbai, Maharashtra, India.
    A 30-year-old male presented to the dermatology department with complaints of multiple ulcers over both legs of 6 years duration. The ulcers had a waxing and waning course with present exacerbation of lesions since 1 month. Dermatological examination revealed multiple ulcers distributed in a reticular pattern over medial and lateral aspects of both lower legs, extensor aspect of both ankles and dorsum of both feet. Read More

    Lipoprotein(a) and livedoid vasculopathy: A new thrombophilic factor?
    Med Hypotheses 2015 Nov 29;85(5):670-4. Epub 2015 Aug 29.
    Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Department of Pathology, R. Dr. Eneas de Carvalho Aguiar, 255 - 3rd Fl, São Paulo, SP CEP 05403-000, Brazil.
    Livedoid vasculopathy is a chronic disorder characterised by recurrent reticulated purpura on lower extremities, associated with painful purpuric or necrotic macules and ulcerations. Current knowledge indicates LV to be a thrombo-occlusive vasculopathy of cutaneous blood vessels; exact pathogenesis is yet to be understood. Elevated levels of lipoprotein(a) have been found in LV patients. Read More

    [Diagnosis of vascular acrosyndromes].
    Ann Dermatol Venereol 2015 Aug-Sep;142(8-9):513-8. Epub 2015 Jul 11.
    Service de dermatologie, UF de dermatologie vasculaire, hôpital Tenon, 4, rue de la Chine, 75970 Paris cedex 20, France. Electronic address:
    Vascular acrosyndromes are associated with vasomotor disorders. They may be paroxysmal, like Raynaud's phenomenon, whitening of the fingers on exposure to cold, or erythromelalgia, a painful form of erythema induced by exposure to heat. Others are permanent or semi-permanent, such as acrocyanosis, chilblains, spontaneous haematoma of the fingers, acrocholose and digital ischaemia or necrosis. Read More

    Expanding the spectrum of livedoid vasculopathy: peculiar neuromuscular manifestations.
    Neuropathol Appl Neurobiol 2015 Oct 30;41(6):849-52. Epub 2015 May 30.
    Department of Internal Medicine and Clinical Immunology, Hospital University Department: Inflammation, Immunopathology and Biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France.

    Pulsed intravenous immunoglobulin therapy in refractory ulcerated livedoid vasculopathy: seven cases and a literature review.
    Dermatol Ther 2015 Sep-Oct;28(5):287-90. Epub 2015 Apr 6.
    Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea.
    Livedoid vasculopathy (LV) is a thrombotic vasculopathy of the skin of unknown origin. No treatment has been validated in this indication, but case reports demonstrated successful use of intravenous immunoglobulins (IVIg) in LV. We assessed the efficacy and tolerability of 2 g/kg IVIg therapy every month for 2∼3 cycles in patients with refractory LV. Read More

    Livedoid vasculopathy and high levels of lipoprotein (a): response to danazol.
    Dermatol Ther 2015 Jul-Aug;28(4):248-53. Epub 2015 Mar 30.
    Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida.
    Livedoid vasculopathy (LV) is a thrombo occlusive disorder presenting with recurrent painful ulcers of lower extremities. Association of LV with increased level of lipoprotein (a) (LP(a)), a risk factor for cardiovascular disease, has been reported. Danazol has been used with success in the management of LV, but none of the previous studies looked at the correlation between response to the treatment and level of LP(a). Read More

    Vasculitides with cutaneous expression in children: clinico-pathological correlations.
    G Ital Dermatol Venereol 2015 Feb 17;150(1):51-71. Epub 2014 Dec 17.
    Department of Clinical-Surgical Diagnostic and Pediatric Science, Unit of Dermatology, University of Pavia, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy -
    The most recent pediatric vasculitis classifications (EULAR/PRINTO/PRES) have proposed the use of an integration of clinical signs and symptoms, laboratory data, imaging and pathologic data. Pediatric vasculitis represent a peculiar clinical-diagnostic model, compared to the corresponding adult pathology chapter, and in particular, dermatopathologic aspects of these diseases identify more specific issues, made contingent by crucial variables such as duration of vasculitis lesion, site of the biopsy, proper biopsy depth, and possibility to correlate histopathological findings with immunopathological results. Possible additional diagnostic difficulties may arise from the fact that, in children, the same systemic disease, such as lupus erythematosus, may present with different clinical manifestations, with histopathological features of a precise type of vasculitis specific for that type of clinical manifestation. Read More

    A Phase II Multicenter Trial With Rivaroxaban in the Treatment of Livedoid Vasculopathy Assessing Pain on a Visual Analog Scale.
    JMIR Res Protoc 2014 Dec 10;3(4):e73. Epub 2014 Dec 10.
    Clinical Trial Support, Muenster, Germany.
    Background: Livedoid vasculopathy is an orphan skin disease characterized by recurrent thrombosis of the cutaneous microcirculation. It manifests itself almost exclusively in the ankles, the back of the feet, and the distal part of the lower legs. Because of the vascular occlusion, patients suffer from intense local ischemic pain. Read More

    Challenging mimickers of primary systemic vasculitis.
    Rheum Dis Clin North Am 2015 ;41(1):141-60, ix
    Rheumatology Unit, Massachusetts General Hospital, Yawkey 2, 55 Fruit Street, Boston, MA 02114, USA.
    The need to distinguish true primary systemic vasculitis from its multiple potential mimickers is one of the most challenging diagnostic conundrums in clinical medicine. This article reviews 9 challenging vasculitis mimickers: fibromuscular dysplasia, calciphylaxis, segmental arterial mediolysis, antiphospholipid syndrome, hypereosinophilic syndrome, lymphomatoid granulomatosis, malignant atrophic papulosis, livedoid vasculopathy, and immunoglobulin G4-related disease. Read More

    Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature.
    Pediatr Rheumatol Online J 2014 10;12:46. Epub 2014 Oct 10.
    Department of Pediatrics C, Schneider Children's Medical Center of Israel, Tel Aviv University, Sackler School of Medicine, Petach Tikvah, Israel.
    Cutaneous Polyarteritis Nodosa (cPAN) was first described in 1931. cPAN is considered a rare disease, its true incidence is unknown. The age of onset is diverse. Read More

    Atrophie blanche: is it associated with venous disease or livedoid vasculopathy?
    Adv Skin Wound Care 2014 Nov;27(11):518-24; quiz 525-6
    Afsaneh Alavi, MD, MSc • Lecturer • Department of Medicine (Dermatology), University of Toronto • Ontario, Canada Jurg Hafner, MD • Professor of Dermatology and Venereology, Senior Staff Physician • Department of Dermatology, University Hospital of Zurich • Switzerland Jan P. Dutz, MD • Professor • Department of Dermatology and Skin Science, University of British Columbia • Vancouver, Canada Dieter Mayer, MD • Associate Professor • Vascular Surgery • Head of Wound Care • University Hospital of Zurich • Switzerland R. Gary Sibbald, BSc, FRCPC(Med Derm), MACP, FAAD, MAPWCA • Professor of Medicine and Public Health • University of Toronto • Ontario, Canada Paulo Ricardo Criado, MD, PhD • Professor • Dermatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo • Brazil Patricia Senet, MD • Associate Professor • Department of Dermatology, Assitance Pubique-Hôpitaux de Paris • France Jeffery P Callen, MD • Professor of Medicine and Chief • Division of Dermatology, University of Louisville • Kentucky Tania J Phillips, MD • Professor • Department of Dermatology, Boston University School of Medicine • Massachusetts Marco Romanelli, MD, PhD • Professor • Department of Dermatology, University of Pisa • Italy Robert S Kirsner, MD, PhD • Professor and Vice Chair • Department of Dermatology, University of Miami Miller School of Medicine • Florida.
    Purpose: The purpose of this learning activity is to provide information about the etiology and treatment of atrophie blanche.

    Target Audience: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care.

    Objectives: After participating in this educational activity, the participant should be better able to:1. Read More

    Sensory ganglionopathy with livedoid vasculopathy controlled by immunotherapy.
    Muscle Nerve 2015 Feb 23;51(2):296-301. Epub 2014 Dec 23.
    Department of Clinical Neurophysiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF.
    Introduction: Livedoid vasculopathy is a rare dermatological condition characterized by painful ulceration, atrophic scarring, and persistent livedo reticularis. The pathogenesis is unclear.

    Methods: We report a patient with biopsy-proven livedoid vasculopathy who developed a progressive sensory ganglionopathy with profound sensory ataxia. Read More

    Livedoid vasculopathy as a marker of systemic disease: report of two cases.
    An Bras Dermatol 2014 Sep-Oct;89(5):822-4
    Fundação Alfredo da Matta, Manaus, AM, Brazil.
    The livedoid vasculopathy is an obstructive vascular process of etiology not yet fully known, being possibly associated with several prothrombotic events. It is clinically characterized by the presence of painful and recurring purpuric lesions, which usually suffer ulceration and evolve with formation of white atrophic scars usually located in the lower limbs. Two cases are here reported of painful ulcerated lesions on the lower limbs, in which the identification of VL enabled the diagnosis of systemic diseases. Read More

    Diffuse Reactive Angioendotheliomatosis Secondary to the Administration of Trabectedin and Pegfilgrastim.
    Am J Dermatopathol 2015 Jul;37(7):581-4
    Departments of *Dermatology, and †Pathology, La Paz University Hospital, Madrid, Spain.
    Diffuse dermal angiomatosis is a rare benign condition considered a variant of reactive angioendotheliomatosis, usually related to vascular disease such as arteriovenous fistula or severe peripheral vascular disease. The most frequent clinical manifestations range from a solitary erythematous patch to an indurated plaque that may ulcerate. A clinical case of a 60-year-old woman who developed generalized livedoid lesions 2 days after the administration of intravenous trabectedin and subcutaneous pegfilgrastim for a recidivant myxoid liposarcoma has been reported. Read More

    Livedoid vasculopathy (LV) associated with sticky platelets syndrome type 3 (SPS type 3) and enhanced activity of plasminogen activator inhibitor (PAI-1) anomalies.
    Int J Dermatol 2014 Dec 29;53(12):1495-7. Epub 2013 Oct 29.
    Dermatology Department, Hospital Central "Ignacio Morones Prieto", Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, México.

    Efficacy of intravenous immunoglobulins in livedoid vasculopathy: long-term follow-up of 11 patients.
    J Am Acad Dermatol 2014 Oct 9;71(4):738-44. Epub 2014 Jul 9.
    Department of Dermatology and Venereology, Rudolfstiftung Hospital, Teaching Hospital of Vienna Medical University, Vienna, Austria.
    Background: Evidence for the efficacy of various therapies of livedoid vasculopathy (LV) is limited.

    Objective: We sought to determine efficacy and tolerability of 2 g/kg of intravenous immunoglobulins (IVIG) every 4 weeks in patients with LV.

    Methods: This was a long-term follow-up study of 11 patients with LV treated with 2 g/kg of IVIG assessing the clinical characteristics, disease course, and quality of life. Read More

    [Skin necrosis: report of eleven cases].
    Rev Med Chil 2014 Jan;142(1):118-24
    Skin necrosis must be considered as a syndrome, because it is a clinical manifestation of different diseases. An early diagnosis is very important to choose the appropriate treatment. Therefore, its causes should be suspected and confirmed quickly. Read More

    Elevated Levels of Coagulation Factor VIII in Patients With Venous Leg Ulcers.
    Int J Low Extrem Wounds 2014 Jun 25;13(2):130-134. Epub 2014 May 25.
    University of Miami, FL, USA.
    Chronic venous disease affects millions of people around the world. Venous valvular incompetencies and venous reflux, often a result of outflow obstruction are important contributors to venous disease. The prevalence of thrombophilia is increased in patients with chronic venous insufficiency (CVI). Read More

    Evaluation of hyperbaric oxygen therapy for chronic wounds.
    J Nippon Med Sch 2014 ;81(1):4-11
    Department of Cutaneous and Mucosal Pathophysiology, Graduate School of Medicine, Nippon Medical School.
    Background: Treating chronic wounds is challenging. Despite standard wound care, some chronic wounds fail to heal. Therefore, hyperbaric oxygen therapy (HBOT) was developed as an adjunct to standard wound care. Read More

    Early-onset stroke and vasculopathy associated with mutations in ADA2.
    N Engl J Med 2014 Mar 19;370(10):911-20. Epub 2014 Feb 19.
    The authors' affiliations are listed in the Appendix.
    Background: We observed a syndrome of intermittent fevers, early-onset lacunar strokes and other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic vasculopathy in three unrelated patients. We suspected a genetic cause because the disorder presented in early childhood.

    Methods: We performed whole-exome sequencing in the initial three patients and their unaffected parents and candidate-gene sequencing in three patients with a similar phenotype, as well as two young siblings with polyarteritis nodosa and one patient with small-vessel vasculitis. Read More

    Livedoid vasculopathy: clinical features and treatment in 24 Chinese patients.
    Acta Derm Venereol 2014 Sep;94(5):574-8
    Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 210042 Nanjing, China.
    Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. We have conducted a retrospective study of clinical features and treatment response of LV in 24 Chinese patients. LV occurred more frequently in women (male:female ratio  1:3). Read More

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