253 results match your criteria Livedoid Vasculopathy


Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin.

Clin Case Rep 2018 Nov 12;6(11):2045-2047. Epub 2018 Sep 12.

Meguro Chen Dermatology Clinic Tokyo Japan.

We reported a patient with systemic lupus erythematosus complicated by livedoid vasculopathy (LV), who responded well to intravenous immunoglobulin and warfarin. Cutaneous lesions of LV resemble those of cutaneous vasculitis. LV should be included in the differential diagnosis of leg ulcerations even in the presence of autoimmune disorders. Read More

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http://dx.doi.org/10.1002/ccr3.1803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230605PMC
November 2018
2 Reads

Dermoscopy of early non-ulcerated livedoid vasculopathy.

Authors:
Uwe Wollina

Acta Dermatovenerol Alp Pannonica Adriat 2018 Sep;27(3):147-148

Department of Dermatology and Allergology, Dresden Academic Teaching Hospital, Dresden, Germany.

Livedoid vasculopathy is a rare disease related to a hypercoagulable state. It can lead to painful and chronic relapsing ulcerations. We report dermoscopic findings of early, non-ulcerated livedoid vasculopathy in five patients. Read More

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September 2018

Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy.

J Dermatol 2018 Aug 29. Epub 2018 Aug 29.

Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

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http://dx.doi.org/10.1111/1346-8138.14633DOI Listing
August 2018
11 Reads

ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease.

Pediatrics 2018 Sep;142(3)

Departments of Microbiology and Immunology and.

Multicentric Castleman disease (MCD) is a rare entity that, unlike unicentric Castleman disease, involves generalized polyclonal lymphoproliferation, systemic inflammation, and multiple-organ system failure resulting from proinflammatory hypercytokinemia, including, in particular, interleukin-6. A subset of MCD is caused by human herpesvirus-8 (HHV-8), although the etiology for HHV-8-negative, idiopathic MCD (iMCD) cases is unknown at present. Recently, a consensus was reached on the diagnostic criteria for iMCD to aid in diagnosis, recognize mimics, and initiate prompt treatment. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2017-2266DOI Listing
September 2018
10 Reads

Livedoid vasculopathy: a compelling diagnosis.

Autops Case Rep 2018 Jul-Sep;8(3):e2018034. Epub 2018 Jul 30.

Universidade de São Paulo (USP), Faculty of Medicine, Department of Dermatology. São Paulo, SP, Brazil.

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http://dx.doi.org/10.4322/acr.2018.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066260PMC

Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports.

Explore (NY) 2018 09 10;14(5):357-366. Epub 2018 Aug 10.

Department of Preventive Medicine, College of Korean Medicine, Daejeon University, 62 Daehak-ro, Daejeon 34520, Republic of Korea. Electronic address:

Introduction: This study was performed to evaluate the clinical effect of a Korean medicine treatment for livedoid vasculopathy (LV).

Methods: Five patients with LV were selected who exhibited blood stasis due to qi stagnation () caused by external cold () or dual deficiency of qi and blood () and who had suffered from chronic episodic LV for at least 2 years. The treatment consisted of Korean herbal medicine, Haechungtang (, HC). Read More

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http://dx.doi.org/10.1016/j.explore.2017.12.008DOI Listing
September 2018
13 Reads

Systemic therapies for leg ulcers.

J Dtsch Dermatol Ges 2018 Jul;16(7):873-890

Department of Dermatology, Venereology and Allergology, University Medical Center Bochum, Bochum, Germany.

Successful management of patients with leg ulcers requires identification of the underlying etiology, with subsequent initiation of causal treatment, if feasible. Supplementary measures of first choice include stage-adjusted wound treatment, usually combined with compression therapy. The significance of systemic drugs has been the subject of controversial debate, depending on the underlying cause of the condition. Read More

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http://dx.doi.org/10.1111/ddg.13586DOI Listing
July 2018
6 Reads

Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms.

Skinmed 2018 1;16(2):125-127. Epub 2018 Apr 1.

Department of Dermatology and Sexually Transmitted Diseases, Lady Hardinge Medical College and Suchita Kriplani Hospital, Shaheed Bhagat Singh Marg, Delhi, India.

38-year-old married woman presented with multiple spontaneous painful ulcers that had involved both forearms for the previous month, along with a single episode of generalized tonic-clonic seizures, with no residual palsy or paresis. She complained of photosensitivity and diffuse hair loss for the past 6 months. She also had had arthralgia for the previous 3 years, which had initially involved the small joints of the fingers (especially the proximal interphalangeal joints) and gradually progressed to involve the larger joints. Read More

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April 2018
1 Read

Ulcerative livedoid vasculopathy responding to clopidogrel.

JAAD Case Rep 2018 Mar 3;4(2):203-205. Epub 2018 Feb 3.

University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993557PMC

Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options.

Acta Derm Venereol 2018 Oct;98(9):842-847

Department of Dermatology, Hôpital Tenon, APHP, Paris, France.

Livedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid vasculopathy and the efficacy of treatments. Patients enrolled had typical livedoid vasculopathy both clinically and histologically. Read More

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http://dx.doi.org/10.2340/00015555-2965DOI Listing
October 2018
4 Reads
3.020 Impact Factor

The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban.

Int J Dermatol 2018 Jun 16;57(6):732-741. Epub 2018 Apr 16.

Centro da Pele Ecuador - CEPI, Quito, Ecuador.

Livedoid vasculopathy (LV) is a thrombotic skin disease characterized by episodic painful ulcerations of the distal aspects of the legs. Its healing process typically leaves small porcelain-white scars called atrophie blanche as a result of the occlusion of cutaneous microcirculation. The main goals of the treatment are pain management and the prevention of ulceration and of progressive scarring in the malleolar area. Read More

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http://dx.doi.org/10.1111/ijd.13997DOI Listing
June 2018
8 Reads
1.230 Impact Factor

Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease.

Am J Dermatopathol 2018 Sep;40(9):682-685

Division of Dermatopathology, Cockerell Dermatopathology, Dallas, TX.

We report a case in which a 43-year-old African American male with medical history of sickle cell disease (SCD) presented with a nonhealing ulcer. Biopsy revealed features of livedoid vasculopathy. Previously, livedoid vasculopathy had only been described in a patient with sickle cell trait, but never in a patient with SCD. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001133DOI Listing
September 2018
3 Reads

Livedoid vasculopathy in a patient with bullous pemphigoid and primary Sjögren's syndrome.

Reumatol Clin 2018 Mar 8. Epub 2018 Mar 8.

Servicio de Dermatología, Hospital Universitario Doctor Peset, Valencia, España.

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http://dx.doi.org/10.1016/j.reuma.2018.01.013DOI Listing
March 2018
5 Reads

Cutaneous refractile foreign body microemboli with intravascular injection of oral medication.

J Cutan Pathol 2018 May 14;45(5):365-368. Epub 2018 Mar 14.

Department of Pathology, Hartford Hospital, Hartford, Connecticut.

Injection drug abuse (IDA) is known to cause a spectrum of systemic and cutaneous complications. Despite the increasing incidence of IDA around the world, there is a paucity of literature discussing cutaneous complications from a dermatopathologic perspective. We present a case of a 35-year-old male with a complex medical history of Von Willebrand disease, Beçhet disease and diverticular disease. Read More

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http://dx.doi.org/10.1111/cup.13125DOI Listing
May 2018
4 Reads

Treatment for Livedoid Vasculopathy: A Systematic Review.

JAMA Dermatol 2018 Feb;154(2):193-202

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Importance: Livedoid vasculopathy is a painful, ulcerative condition of the lower extremities for which no established treatment exists. Current treatment paradigms rely on low levels of evidence, primarily case reports and case series.

Objective: To systematically review the treatment for livedoid vasculopathy and synthesize the available clinical data. Read More

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http://dx.doi.org/10.1001/jamadermatol.2017.4374DOI Listing
February 2018
14 Reads

Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists.

Actas Dermosifiliogr 2018 Apr 23;109(3):278-281. Epub 2017 Oct 23.

Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, España.

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http://dx.doi.org/10.1016/j.ad.2017.07.015DOI Listing
April 2018
3 Reads

Use of Low-dose Oral Warfarin in Three Cases of Livedoid Vasculopathy.

Indian J Dermatol 2017 Sep-Oct;62(5):508-511

Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College and AVBR Hospital, Wardha, Maharashtra, India.

We hereby present our experience of low-dose oral warfarin in the management of three cases of livedoid vasculopathy. Read More

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http://dx.doi.org/10.4103/ijd.IJD_564_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618839PMC
October 2017
9 Reads

Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy.

J Cutan Pathol 2017 Dec 13;44(12):1033-1037. Epub 2017 Oct 13.

Dermatology Department of Hospital das Clínicas, University of Sao Paulo Medical School, São Paulo, Brazil.

Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Read More

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http://doi.wiley.com/10.1111/cup.13043
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http://dx.doi.org/10.1111/cup.13043DOI Listing
December 2017
4 Reads

Livedoid eruption in a patient affected by T-γδ large granular lymphocyte leukaemia.

BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.

Unit of Dermatology, University of Padua, Padova, Italy.

Livedo is an ischaemic dermopathy characterised by a reddish-blue to violaceous mottling of the skin with a net-like reticular appearance. Livedo has been described in association with several medical conditions including lymphoproliferative disorders. Here, we describe the case of a 60-year-old woman who was presented with asymptomatic and persistent livedoid eruption on her trunk, lower and upper extremities as manifestation of an indolent form of T-γδ large granular lymphocyte leukaemia. Read More

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http://dx.doi.org/10.1136/bcr-2017-220051DOI Listing
September 2017
1 Read

Vasculopathies, cutaneous necrosis and emergency in dermatology.

G Ital Dermatol Venereol 2017 Dec 28;152(6):615-637. Epub 2017 Jul 28.

Department of Dermatology, de La Princesa University Hospital, Madrid, Spain.

Most emergencies in dermatology comprise a variety of entities with a usually benign course. However, vasculopathies and vasculitis are not common, but they could represent respectively 1.9% and 4. Read More

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https://www.minervamedica.it/index2.php?show=R23Y2017N06A061
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http://dx.doi.org/10.23736/S0392-0488.17.05727-3DOI Listing
December 2017
23 Reads

Nicolau Syndrome (Embolia Cutis Medicamentosa): A Rare and Poorly Recognized Iatrogenic Cause of Cutaneous Thrombotic Vasculopathy.

Am J Dermatopathol 2018 Mar;40(3):212-215

Department of Pathology, Western General Hospital and the University of Edinburgh, Edinburgh, United Kingdom.

Nicolau syndrome is a rare form of iatrogenic cutaneous necrosis which affects injection sites. Although classically associated with intramuscular injections, it may develop after subcutaneous or other routes of parenteral drug administration. Clinically, it manifests as necrotic ulcers that often develop in a background of erythematous and livedoid reticular patches. Read More

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http://Insights.ovid.com/crossref?an=00000372-201803000-0001
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http://dx.doi.org/10.1097/DAD.0000000000000972DOI Listing
March 2018
4 Reads

Three cases of lymphocytic thrombophilic arteritis presenting with an annular eruption.

Australas J Dermatol 2018 May 28;59(2):e127-e132. Epub 2017 Jul 28.

Department of Anatomical Pathology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

We describe three patients who presented with a striking erythematous non-blanching annular eruption and features of lymphocytic thrombophilic arteritis (LTA), with a prominent lymphocytic vasculitis involving deep dermal vessels. Lymphocytic inflammation was also evident in the superficial vessels and one patient had small superficial ulcers over the ankle area resembling livedoid vasculopathy (LV). Multiple biopsies demonstrated a persistent absence of neutrophils in the infiltrate consistent with a lymphocytic process. Read More

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http://dx.doi.org/10.1111/ajd.12679DOI Listing
May 2018
40 Reads

Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy.

BMJ Case Rep 2017 Jul 24;2017. Epub 2017 Jul 24.

Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

Livedoid vasculopathy (LV) is a thrombotic skin disease characterised by recurrent painful ulcerations and irreversible scar formation on the lower legs, which is caused by occlusion of the cutaneous microcirculation. Edoxaban is one of new oral anticoagulants. It directly inhibits factor Xa in the coagulation pathway and prevents thrombus formation. Read More

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http://dx.doi.org/10.1136/bcr-2017-219943DOI Listing
July 2017
7 Reads

Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban.

Authors:
C Drerup T Goerge

J Eur Acad Dermatol Venereol 2017 Dec 12;31(12):e532. Epub 2017 Jul 12.

Universitaetsklinikum Münster, Muenster, Germany.

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http://dx.doi.org/10.1111/jdv.14404DOI Listing
December 2017
5 Reads

Livedoid Vasculopathy.

Arthritis Rheumatol 2017 Oct 15;69(10):2096. Epub 2017 Aug 15.

Institute of Autoimmune Systemic and Neurological Diseases and National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1002/art.40153DOI Listing
October 2017
13 Reads

Treatment application of rivaroxaban in Chinese patients with livedoid vasculopathy.

J Pain Res 2017 17;10:621-624. Epub 2017 Mar 17.

Department of Rheumatology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.

Livedoid vasculopathy (LV) is a chronic prothrombotic disease of cutaneous micro-circulation resulting in cutaneous ischemia and infarction. As a rare disease, LV has an estimated incidence of ten cases per million. Not only correct diagnosis but also effective treatments are very difficult for patients with LV. Read More

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http://dx.doi.org/10.2147/JPR.S133462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364015PMC
March 2017
5 Reads

Dermoscopic features of livedoid vasculopathy.

Medicine (Baltimore) 2017 Mar;96(11):e6284

aDepartment of Dermatology, College of Medicine, Kaohsiung Medical University bDepartment of Dermatology, Kaohsiung Medical University Hospital cDepartment of Dermatology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung dDepartment of Otolaryngology, Chi Mei Medical Center eCenter of General education, Southern Taiwan University of Technology, Tainan City fDepartment of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan.

Livedoid vasculopathy (atrophie blanche) is a form of thrombotic vasculopathy. It is characterized by small ulcers that become crusted, and heal after several months to produce white atrophic scars. The most commonly affected sites are the lower legs, in particular the dorsum of the feet and ankles. Read More

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http://dx.doi.org/10.1097/MD.0000000000006284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369891PMC
March 2017
3 Reads

[Livedoid vasculopathy secondary to coeliac disease].

Ann Dermatol Venereol 2017 May 7;144(5):374-377. Epub 2017 Mar 7.

Service de dermatologie, HIA Legouest et CHR Metz-Thionville, 57000 Metz, France.

Background: Livedoid vasculopathy (LV) is a painful ulcerative condition involving white atrophy and livedo; a histopathologic feature seen is occlusive dermal vasculopathy. This may be associated with coagulation disorders such as hyperhomocysteinaemia (HHC).

Patients And Methods: We report the case of a 52-year-old woman presenting LV in which an abnormal scan image led us to diagnose coeliac disease. Read More

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http://dx.doi.org/10.1016/j.annder.2017.01.003DOI Listing
May 2017
9 Reads

Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis.

J Eur Acad Dermatol Venereol 2017 Nov 29;31(11):1884-1889. Epub 2017 Mar 29.

Department of Dermatology, Universitätsklinikum Erlangen, Erlangen, Germany.

Background: Livedoid vasculopathy and calciphylaxis are rare skin disorders. Large cohorts of patients have been missing so far for detailed analysis.

Patients And Methods: Data from diagnosis-related groups (DRGs) of hospitalized cases of livedoid vasculopathy (n = 1357) and calciphylaxis (n = 699) were analysed for the years 2008-2013 concerning sex, age and frequency of diagnosis. Read More

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http://dx.doi.org/10.1111/jdv.14190DOI Listing
November 2017
7 Reads

Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil.

Ann Dermatol 2017 Feb 3;29(1):125-127. Epub 2017 Feb 3.

Rheumatology Service, Hospital Nossa Senhora da ConceiçÃo-Grupo Hospitalar ConceiçÃo, Porto Alegre, Brazil.

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http://dx.doi.org/10.5021/ad.2017.29.1.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318515PMC
February 2017
6 Reads

Vasculitic and autoimmune wounds.

J Vasc Surg Venous Lymphat Disord 2017 03 14;5(2):280-292. Epub 2016 Dec 14.

Division of Rheumatology, The George Washington University, School of Medicine and Health Sciences, Washington, D.C.

Objective: Chronic wounds are a major cause of morbidity and mortality. Approximately 20% to 23% of nonhealing wounds that are refractory to vascular intervention have other causes, including vasculitis, pyoderma gangrenosum, and other autoimmune diseases. The purpose of this article was to review the literature across medical and surgical specialties with regard to refractory chronic wounds associated with vasculitis and autoimmune diseases and to delineate clinical outcomes of these wounds in response to vascular and other interventions. Read More

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http://dx.doi.org/10.1016/j.jvsv.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319730PMC
March 2017
29 Reads

Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions.

Cardiovasc Ther 2017 Jun;35(3)

Department of Medical Biology, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Aim: Thrombosis and inflammation play an important role in pathophysiology of livedoid vasculopathy (LV). Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of fibrinolysis and is a pivotal modulator in a broad range of biological processes.

Method: The study specimens were retrospectively selected from archives of pathology department. Read More

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http://dx.doi.org/10.1111/1755-5922.12255DOI Listing
June 2017
29 Reads

Dabigatran in the management of livedoid vasculopathy.

Authors:
T Sawada M Suehiro

Clin Exp Dermatol 2017 Mar 4;42(2):237-239. Epub 2017 Jan 4.

Department of Dermatology, Otsu Municipal Hospital, Otsu, Japan.

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http://dx.doi.org/10.1111/ced.13022DOI Listing
March 2017
1 Read

Pulsed-Dye Laser for Disfiguring Livedoid Changes After Chemoradiotherapy.

Dermatol Surg 2017 06;43(6):892-894

Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, Texas.

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http://dx.doi.org/10.1097/DSS.0000000000001011DOI Listing
June 2017
3 Reads

Livedoid vasculopathy.

Rev Bras Reumatol Engl Ed 2016 Nov - Dec;56(6):554-556. Epub 2016 Mar 19.

Pontifícia Universidade Católica de Campinas, Hospital e Maternidade Celso Pierro, Serviço de Radiologia, Campinas, SP, Brazil.

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http://dx.doi.org/10.1016/j.rbre.2016.02.014DOI Listing
October 2018
3 Reads

[What's new in clinical dermatology?]

Authors:
C Lok

Ann Dermatol Venereol 2016 Dec;143 Suppl 3:S1-S10

Service de Dermatologie, CHU Amiens Picardie, EA 4666, Université Picardie Jules Verne. Electronic address:

Zika virus: what the dermatologist should know. Probably a new vaccine against herpes zoster and postherpetic neuralgia in older adults. Defining moderate, significant and extensive types of pemphigus with ABSIS et PDAI scores. Read More

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http://dx.doi.org/10.1016/S0151-9638(18)30043-7DOI Listing
December 2016
1 Read

A Case of Streptobacillus moniliformis Infection with Cutaneous Leukocytoclastic Vasculitis.

Acta Med Okayama 2016 Oct;70(5):377-381

Department of Dermatology, Okayama City Hospital, Okayama 700-8557,

A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Read More

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http://dx.doi.org/10.18926/AMO/54596DOI Listing
October 2016
64 Reads

Livedoid vasculopathy - a challenging disease.

Acta Reumatol Port 2016 Jul-Sep;41(3):273-274

We present a rare association of idiopathic livedoid vasculopathy (LV) with peripheral sensory neuropathy successfully treated with intravenous immunoglobulin and warfarin and, after its failure, with rituximab. Although LV aetiology remains incompletely understood, the excellent clinical response observed in our patient suggests that B cells may be key players in its pathogenesis. Read More

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October 2017
3 Reads

Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency.

J Dermatol 2017 Feb 24;44(2):198-201. Epub 2016 Oct 24.

Department of Dermatology, Aichi Medical University, Nagakute, Japan.

Livedoid vasculopathy (LV) is a chronic disease with recurrent reticularis and ulcers, mainly affecting the feet and lower legs. The pathogenesis of LV has not been yet thoroughly understood, but thrombosis is thought to play a major role because fibrin deposition within both the wall and lumen of affected vessels is pathologically detected. A 68-year-old woman first presented to our hospital in 2004 with a 6-year history of a reticular rash and ulceration on the lower legs. Read More

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http://dx.doi.org/10.1111/1346-8138.13652DOI Listing
February 2017
9 Reads

Occlusive Nonvasculitic Vasculopathy.

Am J Dermatopathol 2017 Sep;39(9):637-662

*Associate Staff of the Department of Dermatology, Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autónoma, Madrid, Spain; †Associate Staff of the Department of Dermatology, Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain; ‡Director of Dermatopathology, Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain; §Director of Dermatopathology, Dermatopathology Research Unit, Medical University of Graz, Graz, Austria; ¶Director of Dermatopathology, Dermatopathologie Laboratory, Friedrichschafen, Germany; and ‖Chairman of the Department of Dermatology, Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain.

We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Read More

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http://Insights.ovid.com/crossref?an=00000372-201709000-0000
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http://dx.doi.org/10.1097/DAD.0000000000000766DOI Listing
September 2017
55 Reads

Monogenic polyarteritis: the lesson of ADA2 deficiency.

Pediatr Rheumatol Online J 2016 Sep 8;14(1):51. Epub 2016 Sep 8.

UO Pediatria II, Istituto G. Gaslini, Genoa, Italy.

The deficiency of Adenosine Deaminase 2 (DADA2) is a new autoinflammatory disease characterised by an early onset vasculopathy with livedoid skin rash associated with systemic manifestations, CNS involvement and mild immunodeficiency.This condition is secondary to autosomal recessive mutations of CECR1 (Cat Eye Syndrome Chromosome Region 1) gene, mapped to chromosome 22q11.1, that encodes for the enzymatic protein adenosine deaminase 2 (ADA2). Read More

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http://dx.doi.org/10.1186/s12969-016-0111-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015262PMC
September 2016
30 Reads

Persistent cutaneous abdominal ulcerations secondary to diffuse dermal angiomatosis: an underestimated sign for severe atherosclerosis: A case report.

Medicine (Baltimore) 2016 Jul;95(29):e4212

aDepartment of Dermatology bDepartment of Vascular Surgery cDepartment of Pathology dDepartment of Infectious Diseases, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Diffuse dermal angiomatosis (DDA) is a rare, acquired, reactive vascular proliferation, clinically characterized by livedoid erythematous-violaceous plaques, which frequently evolve to ulceration and necrosis. Histopathologically, it is manifested by a diffuse proliferation of endothelial cells within the full thickness of the dermis. DDA has been mainly associated with severe peripheral atherosclerosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000004212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265761PMC
July 2016
12 Reads

Anticoagulants in dermatology.

Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):626-640

Department of Dermatology, Venereology and Leprosy, Shri B. M. Patil Medical College, Hospital and Research Center, BLDE University, Vijayapur, Karnataka, India.

Anticoagulants are the cornerstone of treatment of venous thromboembolism associated with various medical conditions and surgical procedures. They act on different steps of the coagulation pathway and are broadly categorized into heparins, vitamin K antagonists, and inhibitors of thrombin and factor Xa. The classification is evolving as newer and better oral and parenteral anticoagulants are being added. Read More

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http://dx.doi.org/10.4103/0378-6323.184199DOI Listing
May 2017
4 Reads

Livedoid vasculopathy: A review of pathogenesis and principles of management.

Indian J Dermatol Venereol Leprol 2016 Sep-Oct;82(5):478-88

Department of Dermatology, Command Hospital, Pune, Maharashtra, India.

Livedoid vasculopathy is a rare cutaneous disease manifesting as recurrent ulcers on the lower extremities. The ulceration results in atrophic, porcelain white scars termed as atrophie blanche. The pathogenesis is yet to be understood with the main mechanism being hypercoagulability and inflammation playing a secondary role. Read More

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http://dx.doi.org/10.4103/0378-6323.183635DOI Listing
April 2017
29 Reads
1 Citation
1.320 Impact Factor

Rapid remission of severe pain from livedoid vasculopathy by apixaban.

J Eur Acad Dermatol Venereol 2017 Jan 11;31(1):e45-e46. Epub 2016 May 11.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1111/jdv.13691DOI Listing
January 2017
1 Read

Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment.

J Am Acad Dermatol 2016 May;74(5):795-804; quiz 805-6

Boston University School of Medicine, Boston, Massachusetts. Electronic address:

Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. Inherited conditions tend to present either in neonatal period or later in life, while acquired conditions typically occur later in life. Read More

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http://dx.doi.org/10.1016/j.jaad.2015.08.071DOI Listing
May 2016
7 Reads

Successful treatment of livedoid vasculopathy with rivaroxaban.

JAAD Case Rep 2015 Nov 24;1(6):340-1. Epub 2015 Sep 24.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.jdcr.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809376PMC
November 2015
3 Reads

Therapeutic effect of autologous platelet-rich plasma (PRP) on recalcitrant cutaneous ulcers in livedoid vasculopathy.

JAAD Case Rep 2015 Sep 25;1(5):310-1. Epub 2015 Aug 25.

Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan.

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http://dx.doi.org/10.1016/j.jdcr.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809273PMC
September 2015
3 Reads

Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation.

Acta Derm Venereol 2016 11;96(7):987-988

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

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http://dx.doi.org/10.2340/00015555-2416DOI Listing
November 2016
28 Reads

Case series of recalcitrant livedoid vasculopathy treated with rivaroxaban.

Authors:
J M Lee I-H Kim

Clin Exp Dermatol 2016 Jul 19;41(5):559-61. Epub 2016 Mar 19.

Department of Dermatology, Korea University Ansan Hospital, Korea University, Ansan, Korea.

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http://dx.doi.org/10.1111/ced.12829DOI Listing
July 2016
10 Reads