1,190 results match your criteria Lithium Nephropathy


Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy.

J Affect Disord 2019 Apr 8;252:201-211. Epub 2019 Apr 8.

Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Internal Medicine, Division of Translational Informatics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address:

Background: This study compared the largest set of bipolar disorder pharmacotherapies to date (71 drugs and drug combinations) for risk of kidney disorders (KDs).

Methods: This retrospective observational study used the IBM MarketScan® database to analyze data on 591,052 adults with bipolar disorder without prior nephropathy, for onset of KDs (of "moderate" or "high" severity) following psychopharmacotherapy (lithium, mood stabilizing anticonvulsants [MSAs], antipsychotics, antidepressants), or "No drug". Cox regression models included fixed pre-treatment covariates and time-varying drug exposure covariates to estimate the hazard ratio (HR) of each treatment versus "No drug". Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.009DOI Listing
April 2019
1 Read

[Renal toxicity of lithium].

Authors:
Aude Servais

Nephrol Ther 2019 Apr 15;15(2):120-126. Epub 2019 Jan 15.

Service de néphrologie adulte, hôpital Necker, université Paris Descartes, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

Besides its efficiency, lithium has a narrow therapeutic index and can result in considerable toxicity. Among the potential side effects, two types of renal toxicity are observed: a decreased renal concentrating ability and a chronic renal failure. Lithium-induced polyuria is frequent, estimated to affect up to 40% of patients, and develops usually early. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.11.001DOI Listing
April 2019
3 Reads

Role of Oxidative Stress in Lithium-Induced Nephropathy.

Biol Trace Elem Res 2019 Jan 2. Epub 2019 Jan 2.

Laboratory of Experimental Medicine, Hospital Alemán, Buenos Aires, Argentina.

Long-term lithium treatment was associated with chronic kidney disease and renal failure although the underlying pathogenic mechanisms are not certainty known. The aim of this study was to evaluate changes in oxidative stress measures as well as renal functional and structural alterations associated with chronic use of lithium in rats. Forty Wistar male rats were randomized into four groups: control groups fed ad libitum powered standard diet for 1 and 3 months and experimental groups fed ad libitum the same diet supplemented with 60 mmol/kg diet for 1 and 3 months. Read More

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http://dx.doi.org/10.1007/s12011-018-1617-2DOI Listing
January 2019
4 Reads

[Effect of GSK-3β inhibitor on the expression of RANK-RANKL in rats kidney tissue with diabetic nephropathy].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):945-950

Department of Pathology, Affiliated Hospital, Guizhou Medical University, Guiyang 550004, China.

To investigate the effect and significance of GSK-3β inhibitor(LiCl)and RANK-RANKL on the renal tissue of diabetic nephropathy(DN) rats. SD rats were divided into normal control group (NC), DN model group (DN) and GSK-3β inhibitor intervention group (LiCl). Twenty-four hour urine protein of rats were determined by Coomassie brilliant blue. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.12.010DOI Listing
December 2018
2 Reads

Impaired pressure natriuresis and non-dipping blood pressure in rats with early type 1 diabetes mellitus.

J Physiol 2019 Feb 23;597(3):767-780. Epub 2018 Dec 23.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Key Points: Type 1 diabetes mellitus increases cardiovascular risk; hypertension amplifies this risk, while pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, tubular sodium reabsorption was not downregulated, and proximal tubule sodium reabsorption, measured by lithium clearance, was unaffected. Insulin reduced blood glucose in diabetic rats, and rescued the pressure natriuresis response without influencing lithium clearance, but did not restore medullary blood flow. Read More

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http://dx.doi.org/10.1113/JP277332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355628PMC
February 2019
8 Reads

Endogenous Notch Signaling in Adult Kidneys Maintains Segment-Specific Epithelial Cell Types of the Distal Tubules and Collecting Ducts to Ensure Water Homeostasis.

J Am Soc Nephrol 2019 Jan 4;30(1):110-126. Epub 2018 Dec 4.

Pediatrics and Rare Diseases Group and

Background: Notch signaling is required during kidney development for nephron formation and principal cell fate selection within the collecting ducts. Whether Notch signaling is required in the adult kidney to maintain epithelial diversity, or whether its loss can trigger principal cell transdifferentiation (which could explain acquired diabetes insipidus in patients receiving lithium) is unclear.

Methods: To investigate whether loss of Notch signaling can trigger principal cells to lose their identity, we genetically inactivated and , inactivated the Notch signaling target , or induced expression of a Notch signaling inhibitor in all of the nephron segments and collecting ducts in mice after kidney development. Read More

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http://dx.doi.org/10.1681/ASN.2018040440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317606PMC
January 2019
2 Reads

MRI features of lithium-induced nephropathy.

Diagn Interv Imaging 2018 Nov 26. Epub 2018 Nov 26.

IRM Paris 16, 46-48, rue Chardon-Lagache, 75116 Paris, France; Department of abdominal & interventional radiology, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.diii.2018.10.007DOI Listing
November 2018
2 Reads

Lithium and nephrotoxicity: a literature review of approaches to clinical management and risk stratification.

BMC Nephrol 2018 Nov 3;19(1):305. Epub 2018 Nov 3.

IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, 75 Pigdons Road, Geelong, Australia.

Background: Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Whilst the ability of lithium to cause nephrogenic diabetes insipidus is well established, its ability to cause chronic kidney disease is a much more vexing issue, with various studies suggesting both positive and negative causality. Despite these differences, the weight of evidence suggests that lithium has the potential to cause end stage kidney disease, albeit over a prolonged period. Read More

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http://dx.doi.org/10.1186/s12882-018-1101-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215627PMC
November 2018
3 Reads

Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis.

J Am Soc Nephrol 2018 Nov 10;29(11):2658-2670. Epub 2018 Oct 10.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;

Background: The bile acid-activated receptors, including the membrane G protein-coupled receptor TGR5 and nuclear farnesoid X receptor (FXR), have roles in kidney diseases. In this study, we investigated the role of TGR5 in renal water handling and the underlying molecular mechanisms.

Methods: We used tubule suspensions of inner medullary collecting duct (IMCD) cells from rat kidneys to investigate the effect of TGR5 signaling on aquaporin-2 (AQP2) expression, and examined the effects of TGR5 in mice with lithium-induced nephrogenic diabetes insipidus (NDI) and knockout () mice. Read More

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http://www.jasn.org/lookup/doi/10.1681/ASN.2018030271
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http://dx.doi.org/10.1681/ASN.2018030271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218869PMC
November 2018
6 Reads

Cardiovascular comorbidity increases the risk for renal failure during prophylactic lithium treatment.

J Affect Disord 2019 01 17;243:416-420. Epub 2018 Sep 17.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The development of lithium-associated kidney damage is still a matter of controversy. We have addressed this question by investigating the role of somatic comorbidity for developing kidney failure in lithium treated patients.

Methods: The study group comprised of 1741 adult patients with normal creatinine levels at the start of lithium treatment. Read More

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http://dx.doi.org/10.1016/j.jad.2018.09.044DOI Listing
January 2019
20 Reads

Application of a Nanotechnology-Based, Point-of-Care Diagnostic Device in Diabetic Kidney Disease.

Kidney Int Rep 2018 Sep 2;3(5):1110-1118. Epub 2018 Jun 2.

PathShodh Healthcare Pvt. Ltd., Bangalore, India.

Introduction: Early detection of diabetes mellitus (DM) and diabetic kidney disease (DKD) is important for preventing end-stage renal failure and reducing cardiovascular complications. Availability of a validated point-of-care (PoC) device that can measure various DKD markers would be useful in this respect, especially in resource-poor parts of the world.

Methods: We validated a novel nanotechnology-based multianalyte PoC device (minimally invasive and does not require trained medical personnel) against laboratory gold standard tests for the detection of 5 biomarkers related to management of DM and DKD. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127407PMC
September 2018
3 Reads

Safety and efficacy of lithium in children and adolescents: A systematic review in bipolar illness.

Eur Psychiatry 2018 10 18;54:85-97. Epub 2018 Aug 18.

Mood Disorders Program, Tufts Medical Center, Boston, MA, USA; Department of Psychiatry, Tufts University Medical School, Boston, MA, USA; Novartis Institutes for Biomedical Research, Translational Medicine-Neuroscience, Cambridge, MA, USA. Electronic address:

Introduction: Many clinicians are reluctant to use traditional mood-stabilizing agents, especially lithium, in children and adolescents. This review examined the evidence for lithium's safety and efficacy in this population.

Methods: A systematic review was conducted on the use of lithium in children and adolescents with bipolar disorder (BD). Read More

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http://dx.doi.org/10.1016/j.eurpsy.2018.07.012DOI Listing
October 2018
3 Reads

[Renal complications of lithium use: to cease or to continue?]

Ned Tijdschr Geneeskd 2018 May 29;162. Epub 2018 May 29.

GGZ inGeest, Amsterdam.

Lithium is the most effective maintenance therapy for patients with bipolar disorder. Important renal adverse effects of chronic lithium use include nephrogenic diabetes insipidus (prevalence circa 20%) and chronic kidney disease (prevalence circa 10-20% after 5-9 years of lithium use). Chronic lithium use is linked with slowly progressive chronic kidney disease, though it rarely leads to end-stage renal failure (prevalence of 0. Read More

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May 2018
44 Reads

The effect of lithium on the progression-free and overall survival in patients with metastatic differentiated thyroid cancer undergoing radioactive iodine therapy.

Clin Endocrinol (Oxf) 2018 Oct 13;89(4):481-488. Epub 2018 Aug 13.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Objective: Pretreatment with lithium (Li) is associated with an increased residence time of radioactive iodine (RAI) in differentiated thyroid cancer (DTC) metastases. There are no data translating this observation into long-term outcomes. The study goal was to compare the efficacy of three methods of preparation for RAI therapy in metastatic DTC-thyroid hormone withdrawal (THW), THW with pretreatment with Li (THW+Li), and recombinant human TSH (rhTSH). Read More

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http://doi.wiley.com/10.1111/cen.13806
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http://dx.doi.org/10.1111/cen.13806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138537PMC
October 2018
13 Reads

The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature.

Curr Drug Metab 2018 ;19(8):653-662

Department of Psychiatry, School of Medicine, Dokuz Eylul University, Izmir, Turkey.

Background: The incidence and mortality rates of cancer in patients with Bipolar Disorder (BD) is higher compared with the general population. The role of Lithium (Li) in cancer proliferation/inhibition is still a controversial issue in the literature.

Objective: Based on a clinical case with lithium intake and development of a renal tumor, we aimed to explore the relationship between Li use and tumor proliferation, with regard to the mechanism of action of Li. Read More

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http://www.eurekaselect.com/161666/article
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http://dx.doi.org/10.2174/1389200219666180430095933DOI Listing
November 2018
5 Reads

Effects of sildenafil, metformin, and simvastatin on ADH-independent urine concentration in healthy volunteers.

Physiol Rep 2018 04;6(7):e13665

Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by resistance of the kidney to the action of antidiuretic hormone (ADH), resulting in a decrease in the capacity of the kidney to concentrate the urine. NDI can be inherited or acquired due to, for example, chronic lithium therapy. Current treatment options are limited to attempts to lower urine output by a low-solute diet and the use of diuretics or anti-inflammatory drugs. Read More

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http://dx.doi.org/10.14814/phy2.13665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880873PMC
April 2018
3 Reads

Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal.

Nephrology (Carlton) 2018 Oct;23(10):897-903

Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Geelong, Victoria, Australia.

While lithium remains the most efficacious treatment for bipolar disorder, it can cause significant nephrotoxicity. The molecular mechanisms behind both this process and the development of nephrogenic diabetes insipidus still remain to be fully elucidated but appear to involve alterations in glycogen synthase kinase 3 signalling, G2 cell cycle progression arrest, alterations in inositol and prostaglandin signalling pathways, and dysregulated trafficking and transcription of aquaporin 2 water channels. The end result of this is a tubulointerstitial nephropathy with microcyst formation and relative glomerular sparing, both visible on pathology specimens and increasingly noted on non-invasive imaging. Read More

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http://dx.doi.org/10.1111/nep.13263DOI Listing
October 2018
5 Reads

Endocrinopathies and renal outcomes in lithium therapy: impact of lithium toxicity.

QJM 2017 Dec;110(12):821-827

From the Department of Endocrinology.

Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects.

Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Read More

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http://dx.doi.org/10.1093/qjmed/hcx171DOI Listing
December 2017
12 Reads

Lithium-Induced Nephropathy.

N Engl J Med 2018 Mar;378(11):1042

Mayo Clinic, Rochester, MN

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http://dx.doi.org/10.1056/NEJMicm1709438DOI Listing
March 2018
18 Reads

Lithium induces mesenchymal-epithelial differentiation during human kidney development by activation of the Wnt signalling system.

Cell Death Discov 2018 Dec 7;4:13. Epub 2018 Feb 7.

Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.

Kidney function is directly linked to the number of nephrons which are generated until 32-36 weeks gestation in humans. Failure to make nephrons during development leads to congenital renal malformations, whilst nephron loss in adulthood occurs in progressive renal disease. Therefore, an understanding of the molecular processes which underlie human nephron development may help design new treatments for renal disease. Read More

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http://dx.doi.org/10.1038/s41420-017-0021-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841285PMC
December 2018
8 Reads

[Chronic kidney disease and renal failure due to lithium treatment].

Vertex 2017 Sep;28(135):325-329

Laboratorio de Medicina Experimental, Hospital Alemán. Consejo Nacional de Investigaciones Científcas y Técnicas (CONICET). Centro de Patología Experimental y Aplicada, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Lithium has been approved for the treatment of bipolar disorder since the 1970s and even today it is considered a first-line drug for the treatment of this disease. As bipolar disorder often begins between 15-35 years of age and requires long-term treatment, the assessment of the adverse effects of the drugs used is critical. Recently, there has been renewed interest on the risk of chronic kidney disease and kidney failure induced by lithium, with findings suggesting that both complications could be more frequent than previously considered. Read More

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September 2017
3 Reads

Ameliorative Effect of Cactus Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study.

Biomed Res Int 2017 10;2017:8215392. Epub 2017 Dec 10.

Research Unit of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medenine (ISBAM), University of Gabes, 4119 Medenine, Tunisia.

(family Cactaceae) is used in the treatment of a variety of conditions including metal-induced toxicity. The study reports the protective effects of (CCE) against lithium carbonate-induced toxicity in rats. Nephrocardiotoxicity was induced in male Wistar rats by single dose of lithium carbonate (25 mg/kg b. Read More

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https://www.hindawi.com/journals/bmri/2017/8215392/
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http://dx.doi.org/10.1155/2017/8215392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742445PMC
August 2018
20 Reads

Lithium and Renal Impairment: A Review on a Still Hot Topic.

Pharmacopsychiatry 2018 Sep 18;51(5):200-205. Epub 2018 Jan 18.

Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark.

Introduction: Lithium is established as an effective treatment of mania, of depression in bipolar and unipolar disorder, and in maintenance treatment of these disorders. However, due to the necessity of monitoring and concerns about irreversible adverse effects, in particular renal impairment, after long-term use, lithium might be underutilized.

Methods: This study reviewed 6 large observational studies addressing the risk of impaired renal function associated with lithium treatment and methodological issues impacting interpretation of results. Read More

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http://dx.doi.org/10.1055/s-0043-125393DOI Listing
September 2018
6 Reads

Lithium-associated nephropathy in the renal allograft.

Kidney Int 2018 01;93(1):273

Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Spain; Nephrology Unit, Reina Sofia University Hospital, Cordoba, Spain.

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http://dx.doi.org/10.1016/j.kint.2017.08.032DOI Listing
January 2018
9 Reads

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice.

PLoS One 2017 15;12(12):e0189485. Epub 2017 Dec 15.

Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chronic GSK3 inhibition in diabetic nephropathy is not known. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189485PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731748PMC
January 2018
39 Reads

The soluble (Pro) renin receptor does not influence lithium-induced diabetes insipidus but does provoke beiging of white adipose tissue in mice.

Physiol Rep 2017 Nov;5(21)

Department of Internal Medicine, University of Utah, Salt Lake City, Utah.

Earlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy develop polyuria associated NDI that might be secondary to downregulation of renal AQP2. We hypothesized that sPRR-His attenuates indices of NDI associated with lithium treatment. Read More

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http://dx.doi.org/10.14814/phy2.13410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688772PMC
November 2017
13 Reads

The complexities of lithium.

Authors:
Benjamin Ko

Physiol Rep 2017 11;5(21)

Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.14814/phy2.13405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688771PMC
November 2017
1 Read

Recommencing lithium in Older Adults with Bipolar I Disorder.

Australas Psychiatry 2017 Dec 31;25(6):571-573. Epub 2017 Oct 31.

Senior Consultant Old Age Psychiatrist, Central Adelaide Local Health Network, Adelaide, SA, Australia.

Objectives: This paper addresses considerations in recommencing lithium in elderly patients with Bipolar I Disorder and medical comorbidity. We focus on nephrotoxicity and cognitive impairment.

Methods: Case reports and review of relevant literature. Read More

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http://dx.doi.org/10.1177/1039856217738374DOI Listing
December 2017
7 Reads

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.

Am J Physiol Renal Physiol 2018 02 25;314(2):F230-F239. Epub 2017 Oct 25.

The Jackson Laboratory, Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory , Bar Harbor, Maine.

Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary-concentrating defect. Li-NDI occurs due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. Read More

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http://dx.doi.org/10.1152/ajprenal.00297.2017DOI Listing
February 2018
18 Reads

Renal concerns relative to the use of lithium in geriatric bipolar disorder patients.

Ann Clin Psychiatry 2017 Nov;29(4):283-290

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, St. Louis, MO, USA. E-mail:

Background: Lithium is a first-line treatment for bipolar disorder in geriatric patients; however, it has long been associated with potentially significant renal consequences, including chronic kidney disease (CKD).

Methods: We reviewed the available evidence to characterize the effects of lithium on renal function, provide a consensus on periodic monitoring, and propose criteria for transitioning an older patient with bipolar disorder and renal issues to an alternate medication.

Results: Although the evidence on lithium use, duration, and dosage on progression of CKD and end-stage renal disease in geriatric patients is mixed, there is solid evidence that patients receiving lithium generally have a reduced glomerular filtration rate compared with controls. Read More

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November 2017
2 Reads

Continuation of lithium after a diagnosis of chronic kidney disease.

Acta Psychiatr Scand 2017 Dec 19;136(6):615-622. Epub 2017 Oct 19.

Unit for Psychiatric Research, Aalborg University Hospital, Aalborg, Denmark.

Objective: To investigate whether continued lithium or anticonvulsant treatment after a first diagnosis of chronic kidney disease (CKD) was associated with progression to irreversible end-stage kidney disease.

Methods: Nationwide cohort study including all individuals in Denmark in a period from 1995 to 2012 with a diagnosis of CKD and (i) a history of lithium treatment (N = 754, among whom 238 patients had a diagnosis of bipolar disorder) or (ii) a history of anticonvulsant treatment (N = 5.004, among whom 199 patients had a diagnosis of bipolar disorder). Read More

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http://dx.doi.org/10.1111/acps.12820DOI Listing
December 2017
2 Reads

Hypertensive bipolar: chronic lithium toxicity in patients taking ACE inhibitor.

BMJ Case Rep 2017 Aug 28;2017. Epub 2017 Aug 28.

Department of Psychiatry and Mental Health, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

A patient with bipolar I disorder has been treated with lithium and haloperidol for the last 20 years and received an ACE inhibitor for his hypertension since 9 years ago. Despite regular clinic follow-ups and blood monitoring, he recently developed tremors and delirium. On hospital admission, serum level of lithium was far above toxic level. Read More

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http://dx.doi.org/10.1136/bcr-2017-220631DOI Listing
August 2017
6 Reads

[Acute lithium poisoning: epidemiology, clinical characteristics, and treatment].

Emergencias 2017 02;29(1):46-48

Servicio de Nefrología, Hospital Universitario Ramón y Cajal, IRYCIS, UAH, REDinREN Madrid, España.

Lithium continues to be the treatment of choice for bipolar disorder. Acute lithium poisoning is a potentially serious event. We present a retrospective observational significative study of episodes of acute lithium poisoning during a 52- month period. Read More

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February 2017
5 Reads

Lithium Use, but Not Valproate Use, Is Associated With a Higher Risk of Chronic Kidney Disease in Older Adults With Mental Illness.

J Clin Psychiatry 2017 Sep/Oct;78(8):e980-e985

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

Objective: Lithium is an essential mood disorder treatment; however, it remains unclear whether lithium increases chronic kidney disease (CKD) risk. There are few data on this in the elderly, even though older adults may be particularly susceptible to CKD. We wished to determine whether lithium is associated with increased CKD risk relative to valproate in older adults. Read More

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http://www.psychiatrist.com/JCP/article/Pages/2017/v78n07/16
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http://dx.doi.org/10.4088/JCP.16m11125DOI Listing
November 2017
18 Reads

Inverted battery design as ion generator for interfacing with biosystems.

Nat Commun 2017 07 24;8:15609. Epub 2017 Jul 24.

Department of Materials Science and Engineering, University of Maryland College Park, College Park, Maryland 20742, USA.

In a lithium-ion battery, electrons are released from the anode and go through an external electronic circuit to power devices, while ions simultaneously transfer through internal ionic media to meet with electrons at the cathode. Inspired by the fundamental electrochemistry of the lithium-ion battery, we envision a cell that can generate a current of ions instead of electrons, so that ions can be used for potential applications in biosystems. Based on this concept, we report an 'electron battery' configuration in which ions travel through an external circuit to interact with the intended biosystem whereas electrons are transported internally. Read More

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http://dx.doi.org/10.1038/ncomms15609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527283PMC
July 2017
64 Reads

An Investigation of Protective Effects of Litium Borate on Blood and Histopathological Parameters in Acute Cadmium-Induced Rats.

Biol Trace Elem Res 2018 Apr 7;182(2):287-294. Epub 2017 Jul 7.

Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.

This study was carried out to determine the protective effects of lithium borate (LTB) on blood parameters and histopathological findings in experimentally induced acute cadmium (Cd) toxicity in rats. Twenty-eight male Wistar albino rats were used, weighing 200-220 g, and they were randomly divided into four groups, including one control and the following three experimental groups: a Cd group (0.025 mmol/kg), a LTB group (15 mg/kg/day orally for 5 days), and a LTB + Cd group (15 mg/kg/day orally for 5 days and Cd 0. Read More

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http://dx.doi.org/10.1007/s12011-017-1089-9DOI Listing
April 2018
94 Reads

[Comparison of results of open simple nephrectomy secondary to lithiasis in patients with and without nephrostomy].

Cir Cir 2017 Jul - Aug;85(4):325-329. Epub 2017 Jun 27.

Departamento de Urología, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

Background: Simple nephrectomy is the procedure of choice in the treatment of excluded kidneys. The purpose of this study was to describe and compare surgical results in open simple retroperitoneal nephrectomies in patients with and without nephrostomy.

Methodology: 58 patients were analyzed. Read More

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http://dx.doi.org/10.1016/j.circir.2017.05.001DOI Listing
May 2018
35 Reads

To assess the effects of parathyroidectomy (TPTX versus TPTX+AT) for Secondary Hyperparathyroidism in chronic renal failure: A Systematic Review and Meta-Analysis.

Int J Surg 2017 Aug 17;44:353-362. Epub 2017 Jun 17.

Department of General Surgery, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China.

Background: Secondary Hyperparathyroidism (SHPT) requiring parathyroidectomy (PTX) occurs more commonly in patients with progressive chronic kidney disease and in those on long-term lithium therapy. Successful PTX often results in a dramatic drop of parathyroid hormone level, relieves the patient from clinical symptoms, and reduces mortality. However, there is an ongoing debate on the optimal surgical treatment of SHPT. Read More

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http://dx.doi.org/10.1016/j.ijsu.2017.06.029DOI Listing
August 2017
8 Reads

Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability.

Am J Physiol Renal Physiol 2017 09 14;313(3):F669-F676. Epub 2017 Jun 14.

Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands;

Lithium is the mainstay treatment for patients with bipolar disorder, but it generally causes nephrogenic diabetes insipidus (NDI), a disorder in which the renal urine concentrating ability has become vasopressin insensitive. Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of aquaporin-2 (AQP2) water channels, which are essential for water uptake from tubular urine. Recently, we found that the prophylactic administration of acetazolamide to mice effectively attenuated Li-NDI. Read More

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http://www.physiology.org/doi/10.1152/ajprenal.00147.2017
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http://dx.doi.org/10.1152/ajprenal.00147.2017DOI Listing
September 2017
11 Reads

[Lithium treatment in patients with impaired kidney function: Between Scylla and Charybdis].

Fortschr Neurol Psychiatr 2017 May 23;85(5):288-291. Epub 2017 May 23.

Medizinische Universität Innsbruck.

In quite a few patients with bipolar disorder there is no real alternative to lithium treatment despite impaired kidney function. Is it possible to continue lithium treatment despite kidney malfunction by changing dosage and/or frequency of administration? We report on a 65-year-old woman suffering from bipolar-I disorder who had been on lithium treatment for many decades. While on lithium, the glomerular filtration rate (GFR) decreased constantly. Read More

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http://dx.doi.org/10.1055/s-0043-106739DOI Listing
May 2017
9 Reads

Delay in Renal Hemodynamic Response to a Meat Meal in Severe Obesity.

Nephron 2017 23;136(2):151-157. Epub 2017 Mar 23.

Department of Cardio-Thoracic and Respiratory Science, Second University of Naples, Naples, Italy.

Background/aims: Little information is available about the tubular functions and the renal adjustments that take place in obese subjects after a protein meal. How the excess fat may affect renal response to dietary proteins is currently only partially understood. This paper aims to address (i) whether severe obesity, in the absence of other comorbidities, is responsible of kidney dysfunction at either the glomerular or the tubular level and (ii) whether it compromises renal adaptations to a large protein meal. Read More

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http://dx.doi.org/10.1159/000453283DOI Listing
March 2018
7 Reads

Prasugrel suppresses development of lithium-induced nephrogenic diabetes insipidus in mice.

Purinergic Signal 2017 06 23;13(2):239-248. Epub 2017 Feb 23.

Department of Internal Medicine and Center on Aging, University of Utah Health Sciences Center, Veterans Affairs Salt Lake City, Health Care System, 500 Foothill Drive (151M), Salt Lake City, UT, 84148, USA.

Previously, we localized ADP-activated P2Y receptor (R) in rodent kidney and showed that its blockade by clopidogrel bisulfate (CLPD) attenuates lithium (Li)-induced nephrogenic diabetes insipidus (NDI). Here, we evaluated the effect of prasugrel (PRSG) administration on Li-induced NDI in mice. Both CLPD and PRSG belong to the thienopyridine class of ADP receptor antagonists. Read More

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http://dx.doi.org/10.1007/s11302-017-9555-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432483PMC
June 2017
14 Reads
3.890 Impact Factor

Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus.

Am J Physiol Renal Physiol 2017 Oct 22;313(4):F914-F925. Epub 2017 Feb 22.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;

The direct renin inhibitor aliskiren has been shown to be retained and persist in medullary collecting ducts even after treatment is discontinued, suggesting a new mechanism of action for this drug. The purpose of the present study was to investigate whether aliskiren regulates renal aquaporin expression in the collecting ducts and improves urinary concentrating defect induced by lithium in mice. The mice were fed with either normal chow or LiCl diet (40 mmol·kg dry food·day for 4 days and 20 mmol·kg dry food·day for the last 3 days) for 7 days. Read More

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http://dx.doi.org/10.1152/ajprenal.00553.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148297PMC
October 2017
17 Reads

AJKD Atlas of Renal Pathology: Lithium Nephrotoxicity.

Am J Kidney Dis 2017 01;69(1):e1-e2

Department of Pathology, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1053/j.ajkd.2016.11.005DOI Listing
January 2017
5 Reads
5.900 Impact Factor

Renal Fibrosis mRNA Classifier: Validation in Experimental Lithium-Induced Interstitial Fibrosis in the Rat Kidney.

PLoS One 2016 21;11(12):e0168240. Epub 2016 Dec 21.

Department of Medicine, University of Otago, Dunedin, New Zealand.

Accurate diagnosis of fibrosis is of paramount clinical importance. A human fibrosis classifier based on metzincins and related genes (MARGS) was described previously. In this investigation, expression changes of MARGS genes were explored and evaluated to examine whether the MARGS-based algorithm has any diagnostic value in a rat model of lithium nephropathy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168240PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176284PMC
July 2017
3 Reads

Neurotoxicity and nephrotoxicity caused by combined use of lithium and risperidone: a case report and literature review.

BMC Pharmacol Toxicol 2016 12 14;17(1):59. Epub 2016 Dec 14.

Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Combination lithium, a mood stabilizer, and risperidone, an atypical antipsychotic drug, is widely used for treatment of psychotic disorders. Rare reports concern severe adverse drug reaction in multiple organic systems with their combined use. We report two episodes of neurotoxicity and nephrotoxicity in a patient following the combined use of lithium and risperidone. Read More

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http://dx.doi.org/10.1186/s40360-016-0101-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155382PMC
December 2016
31 Reads

Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus.

N Engl J Med 2016 11;375(20):2008-2009

Boston University School of Medicine, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1609483DOI Listing
November 2016
17 Reads

Malva sylvestris extract protects upon lithium carbonate-induced kidney damages in male rat.

Biomed Pharmacother 2016 Dec 22;84:1099-1107. Epub 2016 Oct 22.

Higher Institute of Applied Biology ISBAM Medenine 4119, University of Gabes, Tunisia; Laboratory of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medenine, University of Gabes, 4119 Medenine, Tunisia.

Malva sylvestris has recently attracted special attention due to its potential activities in many chronic disorders. We aimed to assess the beneficial effects of Malva sylvestris extract against lithium carbonate induced renal damage in male Wistar rats. For this purpose, Malva sylvestris extract at a dose of 0. Read More

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http://dx.doi.org/10.1016/j.biopha.2016.10.026DOI Listing
December 2016
19 Reads

Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism.

Physiol Rep 2016 11;4(21)

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Patients with chronic kidney disease (CKD) are at increased risk for bone fractures compared with the general population. Repression of the Wnt/β-catenin signaling pathway is associated with bone abnormalities. Inhibition of glycogen synthase kinase (GSK)-3β, a critical component of the Wnt/β-catenin signaling pathway, increases bone volume through accumulation of β-catenin. Read More

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http://doi.wiley.com/10.14814/phy2.13010
Publisher Site
http://dx.doi.org/10.14814/phy2.13010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112491PMC
November 2016
7 Reads