1,227 results match your criteria Lithium Nephropathy


Effects of Long-Term Endurance Exercise and Lithium Treatment on Neuroprotective Factors in Hippocampus of Obese Rats.

Int J Environ Res Public Health 2020 May 10;17(9). Epub 2020 May 10.

Department of Physical Education, College of Physical Education, Keimyung University, Daegu 42601, Korea.

To investigate the effects of long-term lithium treatment and low intensity endurance exercise on brain-derived neurotrophic factor (BDNF) expression and glycogen synthase kinase 3 beta (GSK3β) activity in the hippocampus of obese rats. Fifty 10-week-old male Sprague-Dawley rats were selected. There was a control group of 10 rats (chow control group) while the other forty rats were fed on a high-fat diet for eight weeks to induce obesity. Read More

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http://dx.doi.org/10.3390/ijerph17093317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246857PMC

Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway.

Sci Rep 2020 Mar 31;10(1):5708. Epub 2020 Mar 31.

Biogem S.c.a.r.l., Istituto di Ricerche Genetiche "Gaetano Salvatore", Ariano Irpino, Italy.

Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-type intercalated cells increases while the fraction of principal cells decreases along the outer medullary collecting duct in rats. Read More

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http://dx.doi.org/10.1038/s41598-020-61882-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109050PMC

Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy.

Kidney Int 2020 Feb 23;97(2):350-369. Epub 2019 Nov 23.

Laboratory of Pathophysiology, University Antwerp, Antwerp, Belgium. Electronic address:

Almost 30 years after the detection of chronic interstitial nephritis in agricultural communities (CINAC) its etiology remains unknown. To help define this we examined 34 renal biopsies from Sri Lanka, El Salvador, India and France of patients with chronic kidney disease 2-3 and diagnosed with CINAC by light and electron microscopy. In addition to known histopathology, we identified a unique constellation of proximal tubular cell findings including large dysmorphic lysosomes with a light-medium electron-dense matrix containing dispersed dark electron-dense non-membrane bound "aggregates". Read More

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http://dx.doi.org/10.1016/j.kint.2019.11.009DOI Listing
February 2020

Systematic review and practical guideline for the prevention and management of the renal side effects of lithium therapy.

Eur Neuropsychopharmacol 2020 Feb 11;31:16-32. Epub 2019 Dec 11.

Department of Nephrology, Jeroen Bosch Ziekenhuis, Henri Dunantstraat 1, 5223 GZ, 's-Hertogenbosch, The Netherlands; Department of Geriatric Medicine, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.

Lithium is the first line therapy of bipolar mood disorder. Lithium-induced nephrogenic diabetes insipidus (Li-NDI) and lithium nephropathy (Li-NP, i.e. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.11.006DOI Listing
February 2020

The Role of Lithium in Management of Endocrine Tumors-A Comprehensive Review.

Front Oncol 2019 18;9:1092. Epub 2019 Oct 18.

Metabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.

Epidemiological data reveal that treatment with lithium, a mood stabilizer, is associated with decreased incidence and mortality of certain cancer types, such as melanoma. Therefore, repositioning of lithium as an anticancer agent has emerged as a promising strategy in oncology. Since lithium affects the physiology of several endocrine tissues, the goal of this study was to analyze the role of lithium in the pathogenesis and treatment of tumors of the endocrine system. Read More

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http://dx.doi.org/10.3389/fonc.2019.01092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842984PMC
October 2019

A Review for Lithium: Pharmacokinetics, Drug Design, and Toxicity.

CNS Neurol Disord Drug Targets 2019 ;18(10):769-778

Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.

Lithium as a mood stabilizer has been used as the standard pharmacological treatment for Bipolar Disorder (BD) for more than 60 years. Recent studies have also shown that it has the potential for the treatment of many other neurodegenerative disorders, including Alzheimer's, Parkinson's and Huntington's disease, through its neurotrophic, neuroprotective, antioxidant and anti-inflammatory actions. Therefore, exploring its pharmacokinetic features and designing better lithium preparations are becoming important research topics. Read More

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http://dx.doi.org/10.2174/1871527318666191114095249DOI Listing
January 2019

Looking Beyond Numbers: Lithium Toxicity Within Therapeutic Levels.

Am J Med 2020 04 21;133(4):e155-e156. Epub 2019 Oct 21.

Consultant, Division of Advanced Internal Medicine, University Medicine Cluster, National University Hospital, National University Health System, Singapore; Instructor, Yong Loo Lin School of Medicine, National University of Singapore.

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http://dx.doi.org/10.1016/j.amjmed.2019.09.021DOI Listing
April 2020
1 Read
5.003 Impact Factor

Lithium-related medication problems on nonpsychiatric inpatient medical units.

Am J Health Syst Pharm 2019 Nov;76(Supplement_4):S96-S101

Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, VA.

Purpose: Results of a study of medication-related problems (MRPs) associated with lithium use on nonpsychiatric inpatient medical units are reported.

Methods: In a single-center, retrospective study, the records of all patients hospitalized over a 21-month period who received lithium or had a documented serum lithium concentration during hospitalization were evaluated. The primary objective was to identify patient-specific factors associated with lithium MRPs on nonpsychiatric inpatient medical units. Read More

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http://dx.doi.org/10.1093/ajhp/zxz212DOI Listing
November 2019

High Rate of Occult Urolithiasis in Normocalcemic Primary Hyperparathyroidism.

Kidney Blood Press Res 2019 20;44(5):1189-1195. Epub 2019 Sep 20.

Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Hospital Agamenon Magalhães, University of Pernambuco Medical School, Recife, Brazil,

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is characterized by elevations in serum parathyroid hormone levels in the presence of normal serum calcium concentrations after exclusion of secondary hyperparathyroidism. We have previously demonstrated no differences in the prevalence of clinically active urolithiasis between NPHPT and hypercalcemic asymptomatic PHPT, and that it is significantly higher in postmenopausal osteoporotic women with NPHPT in comparison to women with normal serum PTH and calcium concentrations. Few studies have addressed the occurrence of silent or occult kidney stones in asymptomatic hypercalcemic PHPT, but no data are available for NPHPT. Read More

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http://dx.doi.org/10.1159/000502578DOI Listing
March 2020
2 Reads

Lithium: balancing mood, water, and renal function decline.

Authors:
D Severs

Neth J Med 2019 05;77(4):129-130

Department of Internal Medicine, Division of Nephrology & Kidney Transplantation, Erasmus University Medical Centre, Rotterdam, the Netherlands.

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May 2019
3 Reads

Renal concentrating ability and glomerular filtration rate in lithium-treated patients.

Neth J Med 2019 05;77(4):139-149

Background: Lithium is the most effective drug for mood stabilization in bipolar disorder. However, lithium exposure has been associated with an impaired renal concentrating ability (RCA) and glomerular filtration rate (GFR). We examined RCA and estimated GFR in a cohort of patients treated with lithium. Read More

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May 2019
3 Reads

Partial nephrogenic diabetes insipidus associated with lithium therapy.

BMJ Case Rep 2019 Sep 6;12(9). Epub 2019 Sep 6.

Chemical Pathology, Epsom and Saint Helier University Hospitals NHS Trust Epsom Hospital, Carshalton, UK.

A 40-year-old Caucasian man developed excessive thirst and polyuria particularly at night over the preceding 6 months. He had been taking lithium for 16 years for the treatment of bipolar affective disorder. Investigations revealed subnormal maximum urinary concentrating ability after 8 hours of water deprivation and only a borderline response of urine osmolality to exogenous desmopressin given by intramuscular injection. Read More

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http://dx.doi.org/10.1136/bcr-2019-231093DOI Listing
September 2019
1 Read

Extracellular Nucleotides and P2 Receptors in Renal Function.

Physiol Rev 2020 01 22;100(1):211-269. Epub 2019 Aug 22.

Departments of Medicine and Pharmacology, University of California San Diego & VA San Diego Healthcare System, San Diego, California; Centre for Nephrology, Division of Medicine, University College London, London, United Kingdom; IMED ECD CVRM R&D, AstraZeneca, Gothenburg, Sweden; Department of Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, Alabama; Department of Biomedicine/Physiology, Aarhus University, Aarhus, Denmark; Departments of Internal Medicine and Nutrition and Integrative Physiology, and Center on Aging, University of Utah Health & Nephrology Research, VA Salt Lake City Healthcare System, Salt Lake City, Utah.

The understanding of the nucleotide/P2 receptor system in the regulation of renal hemodynamics and transport function has grown exponentially over the last 20 yr. This review attempts to integrate the available data while also identifying areas of missing information. First, the determinants of nucleotide concentrations in the interstitial and tubular fluids of the kidney are described, including mechanisms of cellular release of nucleotides and their extracellular breakdown. Read More

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http://dx.doi.org/10.1152/physrev.00038.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985785PMC
January 2020
4 Reads

Lithium Therapy Associated With Renal and Upper and Lower Urinary Tract Tumors: Results From a Retrospective Single-Center Analysis.

J Clin Psychopharmacol 2019 Sep/Oct;39(5):530-532

Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany Department of Urology University of Ulm Ulm, Germany Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1097/JCP.0000000000001098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727908PMC

[Minimal change disease during lithium therapy: case report].

G Ital Nefrol 2019 Jul 24;36(4). Epub 2019 Jul 24.

UO Nefrologia e Dialisi, Ospedale Santa Maria delle Croci, Ravenna, Ausl Romagna.

Lithium is a largely used and effective therapy in the treatment of bipolar disorder. Its toxic effects on kidneys are mostly diabetes insipidus, hyperchloremic metabolic acidosis and tubulointerstitial nephritis. Also, a correlation between lithium and minimal change disease has sometimes been described. Read More

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July 2019
4 Reads

GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition.

Redox Biol 2019 09 17;26:101275. Epub 2019 Jul 17.

Division of Kidney Disease and Hypertension, Brown University School of Medicine, Providence, RI, 02903, United States; Division of Nephrology, University of Toledo College of Medicine, Toledo, OH, 43614, United States; Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, 43614, United States. Electronic address:

Transition of acute kidney injury (AKI) to chronic kidney disease (CKD) represents an important cause of kidney failure. However, how AKI is transformed into CKD remains elusive. Following folic acid injury, mice developed AKI with ensuing CKD transition, featured by variable degrees of interstitial fibrosis and tubular cell atrophy and growth arrest. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669347PMC
September 2019
3 Reads

Recurring Nephrotic Syndrome After Lithium Medication: A Case Report.

J Clin Psychopharmacol 2019 Sep/Oct;39(5):516-518

Department of Psychiatry and Psychotherapy University Hospital LMU Munich Munich, Germany Department of Psychiatry and Psychotherapy University Hospital LMU Munich Munich, Germany Drug Commission of the German Medical Association Berlin, Germany Department of Psychiatry and Psychotherapy University Hospital LMU Munich Munich, Germany.

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http://dx.doi.org/10.1097/JCP.0000000000001078DOI Listing
April 2020
1 Read

Lithium-Induced Chronic Kidney Disease in a Pediatric Patient.

Case Rep Pediatr 2019 3;2019:5406482. Epub 2019 Jun 3.

University of Massachusetts Memorial Children's Medical Center, University Campus, Department of Radiology, 55 Lake Avenue North, Worcester, MA 01655, USA.

Lithium-induced nephropathy usually manifests in adulthood as it develops slowly after many years of cumulative exposure. There is very limited information available in pediatric patients. Renal function monitoring and timely intervention is the key in preventing lithium-induced chronic kidney disease in these patients. Read More

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http://dx.doi.org/10.1155/2019/5406482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589238PMC

[Ultrasonography in chronic lithium nephropathy: a case report].

G Ital Nefrol 2019 Jun 11;36(3). Epub 2019 Jun 11.

U.O. Nefrologia, Ospedale Santa Maria della Pietà, Nola, Italia.

Lithium has always been used as a first-choice therapy in bipolar disorders. However, its therapeutic index is restricted by placing patients at risk of potential nephrotoxic effects ranging from polyuria, to Insipid Nephrogenic Diabetes, to chronic kidney disease with a slow reduction of renal function over time. The Nephrologist has the role to diagnose chronic lithium nephropathy, monitoring its evolution and optimizing the management of risks associated with the treatment. Read More

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June 2019
6 Reads

Lithium and Not Acetoacetate Influences the Growth of Cells Treated with Lithium Acetoacetate.

Int J Mol Sci 2019 Jun 25;20(12). Epub 2019 Jun 25.

Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, 5020 Salzburg, Austria.

The ketogenic diet (KD), a high-fat/low-carbohydrate/adequate-protein diet, has been proposed as a treatment for a variety of diseases, including cancer. KD leads to generation of ketone bodies (KBs), predominantly acetoacetate (AcAc) and 3-hydroxy-butyrate, as a result of fatty acid oxidation. Several studies investigated the antiproliferative effects of lithium acetoacetate (LiAcAc) and sodium 3-hydroxybutyrate on cancer cells in vitro. Read More

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http://dx.doi.org/10.3390/ijms20123104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628210PMC
June 2019
5 Reads
2.862 Impact Factor

Triterpene derivative improves the renal function of streptozotocin-induced diabetic rats: a follow-up study on maslinic acid.

Ren Fail 2019 Nov;41(1):547-554

d School of Laboratory Medicine and Medical Sciences , University of KwaZulu-Natal , Durban , South Africa.

Reports indicate that oral administration of plant-derived maslinic acid (MA) exhibits hypoglycemic and renoprotective effects in streptozotocin (STZ)-induced diabetic rats. Challenges with triterpenes such as MA include low bioavailabilty which affects treatment efficacy in experimental animals. The goal of this study was to synthesize the MA derivative phenylhydrazine (PH-MA) in an effort to improve the efficacy of MA. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1623818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598493PMC
November 2019

Effects of Dapagliflozin on Volume Status When Added to Renin-Angiotensin System Inhibitors.

J Clin Med 2019 May 31;8(6). Epub 2019 May 31.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.

Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart and kidney failure in patients with type 2 diabetes, possibly due to diuretic effects. Previous non-placebo-controlled studies with SGLT2 inhibitors observed changes in volume markers in healthy individuals and in patients with type 2 diabetes with preserved kidney function. It is unclear whether patients with type 2 diabetes and signs of kidney damage show similar changes. Read More

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http://dx.doi.org/10.3390/jcm8060779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616433PMC
May 2019
21 Reads

Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2,4,6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells.

Biointerphases 2019 05 3;14(2):021007. Epub 2019 May 3.

UNC/NCSU Joint Department of Biomedical Engineering, North Carolina State University, Campus Box 7115, 911 Oval Drive, Raleigh, North Carolina 27695.

Gelatin methacryloyl (GelMA) and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator are commonly used in combination to produce a photosensitive polymer but there are concerns that must be addressed: the presence of unreacted monomer is well known to be cytotoxic, and lithium salts are known to cause acute kidney injury. In this study, acellular 10% GelMA hydrogels cross-linked with different LAP concentrations and cross-linking illumination times were evaluated for their cytotoxicity, photosensitizing potential, and elastic moduli. Alamar Blue and CyQuant Direct Cell viability assays were performed on human primary renal proximal tubule epithelial cells (hRPTECs) exposed to extracts of each formulation. Read More

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http://dx.doi.org/10.1116/1.5095886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499620PMC
May 2019
7 Reads

Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy.

J Affect Disord 2019 06 8;252:201-211. Epub 2019 Apr 8.

Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Internal Medicine, Division of Translational Informatics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address:

Background: This study compared the largest set of bipolar disorder pharmacotherapies to date (71 drugs and drug combinations) for risk of kidney disorders (KDs).

Methods: This retrospective observational study used the IBM MarketScan® database to analyze data on 591,052 adults with bipolar disorder without prior nephropathy, for onset of KDs (of "moderate" or "high" severity) following psychopharmacotherapy (lithium, mood stabilizing anticonvulsants [MSAs], antipsychotics, antidepressants), or "No drug". Cox regression models included fixed pre-treatment covariates and time-varying drug exposure covariates to estimate the hazard ratio (HR) of each treatment versus "No drug". Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.009DOI Listing
June 2019
11 Reads

Clozapine-Associated Kidney Injury Complicated by Lithium Toxicity: A Case Report and Literature Review.

Authors:
Benjamin DeLucia

J Clin Psychopharmacol 2019 May/Jun;39(3):273-275

Department of Psychiatry, State University of New York at Stony Brook, Stony Brook, NY

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http://dx.doi.org/10.1097/JCP.0000000000001042DOI Listing
August 2019
8 Reads

Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers.

J Clin Psychopharmacol 2019 May/Jun;39(3):238-242

Department of Psychiatry, University Hospital Brno, Faculty of Medicine Masaryk University, Brno, Czech Republic.

Background: Lithium in the form of lithium carbonate (Li2CO3) has become one of the most effective and widely prescribed drugs for mood stabilization. However, lithium has adverse effects on renal tubular functions, such as decreased concentrating function of the kidneys, and even occasional symptoms of nephrogenous diabetes insipidus occur with additional evidence of glomerular disruption in lithium-treated patients.

Methods: We assessed the kidney function of patients with bipolar disorder who are under long-term lithium treatment using novel markers of kidney damage such as plasma neutrophil gelatinase-associated lipocalin, cystatin C, albuminuria, estimated glomerular filtration rate, Chronic Kidney Disease-Epidemiology Investigation using creatinine and cystatin C, and serum and urinary osmolality, and compared the results with those of age-matched patients with bipolar disorder not treated with lithium. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001030DOI Listing
August 2019
22 Reads

[Renal toxicity of lithium].

Authors:
Aude Servais

Nephrol Ther 2019 Apr 15;15(2):120-126. Epub 2019 Jan 15.

Service de néphrologie adulte, hôpital Necker, université Paris Descartes, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

Besides its efficiency, lithium has a narrow therapeutic index and can result in considerable toxicity. Among the potential side effects, two types of renal toxicity are observed: a decreased renal concentrating ability and a chronic renal failure. Lithium-induced polyuria is frequent, estimated to affect up to 40% of patients, and develops usually early. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.11.001DOI Listing
April 2019
11 Reads

Role of Oxidative Stress in Lithium-Induced Nephropathy.

Biol Trace Elem Res 2019 Oct 2;191(2):412-418. Epub 2019 Jan 2.

Laboratory of Experimental Medicine, Hospital Alemán, Buenos Aires, Argentina.

Long-term lithium treatment was associated with chronic kidney disease and renal failure although the underlying pathogenic mechanisms are not certainty known. The aim of this study was to evaluate changes in oxidative stress measures as well as renal functional and structural alterations associated with chronic use of lithium in rats. Forty Wistar male rats were randomized into four groups: control groups fed ad libitum powered standard diet for 1 and 3 months and experimental groups fed ad libitum the same diet supplemented with 60 mmol/kg diet for 1 and 3 months. Read More

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http://dx.doi.org/10.1007/s12011-018-1617-2DOI Listing
October 2019
11 Reads

[Effect of GSK-3β inhibitor on the expression of RANK-RANKL in rats kidney tissue with diabetic nephropathy].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):945-950

Department of Pathology, Affiliated Hospital, Guizhou Medical University, Guiyang 550004, China.

To investigate the effect and significance of GSK-3β inhibitor(LiCl)and RANK-RANKL on the renal tissue of diabetic nephropathy(DN) rats. SD rats were divided into normal control group (NC), DN model group (DN) and GSK-3β inhibitor intervention group (LiCl). Twenty-four hour urine protein of rats were determined by Coomassie brilliant blue. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.12.010DOI Listing
December 2018
8 Reads

Impaired pressure natriuresis and non-dipping blood pressure in rats with early type 1 diabetes mellitus.

J Physiol 2019 02 23;597(3):767-780. Epub 2018 Dec 23.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Key Points: Type 1 diabetes mellitus increases cardiovascular risk; hypertension amplifies this risk, while pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, tubular sodium reabsorption was not downregulated, and proximal tubule sodium reabsorption, measured by lithium clearance, was unaffected. Insulin reduced blood glucose in diabetic rats, and rescued the pressure natriuresis response without influencing lithium clearance, but did not restore medullary blood flow. Read More

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http://dx.doi.org/10.1113/JP277332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355628PMC
February 2019
29 Reads

Endogenous Notch Signaling in Adult Kidneys Maintains Segment-Specific Epithelial Cell Types of the Distal Tubules and Collecting Ducts to Ensure Water Homeostasis.

J Am Soc Nephrol 2019 01 4;30(1):110-126. Epub 2018 Dec 4.

Pediatrics and Rare Diseases Group and

Background: Notch signaling is required during kidney development for nephron formation and principal cell fate selection within the collecting ducts. Whether Notch signaling is required in the adult kidney to maintain epithelial diversity, or whether its loss can trigger principal cell transdifferentiation (which could explain acquired diabetes insipidus in patients receiving lithium) is unclear.

Methods: To investigate whether loss of Notch signaling can trigger principal cells to lose their identity, we genetically inactivated and , inactivated the Notch signaling target , or induced expression of a Notch signaling inhibitor in all of the nephron segments and collecting ducts in mice after kidney development. Read More

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http://dx.doi.org/10.1681/ASN.2018040440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317606PMC
January 2019
8 Reads

MRI features of lithium-induced nephropathy.

Diagn Interv Imaging 2019 May 27;100(5):317-318. Epub 2018 Nov 27.

IRM Paris 16, 46-48, rue Chardon-Lagache, 75116 Paris, France; Department of abdominal & interventional radiology, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.diii.2018.10.007DOI Listing
May 2019
11 Reads

Lithium and nephrotoxicity: a literature review of approaches to clinical management and risk stratification.

BMC Nephrol 2018 11 3;19(1):305. Epub 2018 Nov 3.

IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, 75 Pigdons Road, Geelong, Australia.

Background: Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Whilst the ability of lithium to cause nephrogenic diabetes insipidus is well established, its ability to cause chronic kidney disease is a much more vexing issue, with various studies suggesting both positive and negative causality. Despite these differences, the weight of evidence suggests that lithium has the potential to cause end stage kidney disease, albeit over a prolonged period. Read More

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http://dx.doi.org/10.1186/s12882-018-1101-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215627PMC
November 2018
8 Reads

Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis.

J Am Soc Nephrol 2018 11 10;29(11):2658-2670. Epub 2018 Oct 10.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;

Background: The bile acid-activated receptors, including the membrane G protein-coupled receptor TGR5 and nuclear farnesoid X receptor (FXR), have roles in kidney diseases. In this study, we investigated the role of TGR5 in renal water handling and the underlying molecular mechanisms.

Methods: We used tubule suspensions of inner medullary collecting duct (IMCD) cells from rat kidneys to investigate the effect of TGR5 signaling on aquaporin-2 (AQP2) expression, and examined the effects of TGR5 in mice with lithium-induced nephrogenic diabetes insipidus (NDI) and knockout () mice. Read More

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http://www.jasn.org/lookup/doi/10.1681/ASN.2018030271
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http://dx.doi.org/10.1681/ASN.2018030271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218869PMC
November 2018
15 Reads

Comment on 'Continuation of lithium after a diagnosis of chronic kidney disease'.

Acta Psychiatr Scand 2018 09;138(3):275

Concord Repatriation General Hospital, Concord, NSW, Australia.

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http://dx.doi.org/10.1111/acps.12908DOI Listing
September 2018
6 Reads

Response to the comments on 'Continuation of lithium after a diagnosis of chronic kidney disease'.

Acta Psychiatr Scand 2018 09;138(3):275-276

Unit for Psychiatric Research, Aalborg University Hospital, Psychiatry, Aalborg, Denmark.

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http://dx.doi.org/10.1111/acps.12916DOI Listing
September 2018
5 Reads

Diagnosis and management of central diabetes insipidus in adults.

Clin Endocrinol (Oxf) 2019 01 23;90(1):23-30. Epub 2018 Oct 23.

Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.

Central diabetes insipidus (CDI) is characterized by hypotonic polyuria due to impairment of AVP secretion from the posterior pituitary. In clinical practice, it needs to be distinguished from renal resistance to the antidiuretic effects of AVP (nephrogenic DI), and abnormalities of thirst appreciation (primary polydipsia). As nephrogenic diabetes insipidus is rare in adults, unless they are treated with lithium salts, the practical challenge is how to differentiate between CDI and clinical disorders of excess thirst. Read More

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http://dx.doi.org/10.1111/cen.13866DOI Listing
January 2019
5 Reads

Cardiovascular comorbidity increases the risk for renal failure during prophylactic lithium treatment.

J Affect Disord 2019 01 17;243:416-420. Epub 2018 Sep 17.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The development of lithium-associated kidney damage is still a matter of controversy. We have addressed this question by investigating the role of somatic comorbidity for developing kidney failure in lithium treated patients.

Methods: The study group comprised of 1741 adult patients with normal creatinine levels at the start of lithium treatment. Read More

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http://dx.doi.org/10.1016/j.jad.2018.09.044DOI Listing
January 2019
39 Reads

Genetic deletion of ADP-activated P2Y receptor ameliorates lithium-induced nephrogenic diabetes insipidus in mice.

Acta Physiol (Oxf) 2019 02 31;225(2):e13191. Epub 2018 Oct 31.

Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.

Aim: Therapeutic use of lithium in bipolar disorder is limited by the development of nephrogenic diabetes insipidus (NDI). We reported that pharmacological blockade of P2Y receptor (R) with clopidogrel or prasugrel significantly ameliorated lithium-induced NDI in rodents. Using mice genetically lacking P2Y -R we evaluated whether the observed amelioration is mediated through P2Y -R METHODS: P2ry12 mouse line (C57/BL6) was rederived from cryopreserved embryos of the knockout (KO) mice generated by Deltagen Inc. Read More

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http://dx.doi.org/10.1111/apha.13191DOI Listing
February 2019
2 Reads
4.382 Impact Factor

Application of a Nanotechnology-Based, Point-of-Care Diagnostic Device in Diabetic Kidney Disease.

Kidney Int Rep 2018 Sep 2;3(5):1110-1118. Epub 2018 Jun 2.

PathShodh Healthcare Pvt. Ltd., Bangalore, India.

Introduction: Early detection of diabetes mellitus (DM) and diabetic kidney disease (DKD) is important for preventing end-stage renal failure and reducing cardiovascular complications. Availability of a validated point-of-care (PoC) device that can measure various DKD markers would be useful in this respect, especially in resource-poor parts of the world.

Methods: We validated a novel nanotechnology-based multianalyte PoC device (minimally invasive and does not require trained medical personnel) against laboratory gold standard tests for the detection of 5 biomarkers related to management of DM and DKD. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127407PMC
September 2018
11 Reads

Safety and efficacy of lithium in children and adolescents: A systematic review in bipolar illness.

Eur Psychiatry 2018 10 18;54:85-97. Epub 2018 Aug 18.

Mood Disorders Program, Tufts Medical Center, Boston, MA, USA; Department of Psychiatry, Tufts University Medical School, Boston, MA, USA; Novartis Institutes for Biomedical Research, Translational Medicine-Neuroscience, Cambridge, MA, USA. Electronic address:

Introduction: Many clinicians are reluctant to use traditional mood-stabilizing agents, especially lithium, in children and adolescents. This review examined the evidence for lithium's safety and efficacy in this population.

Methods: A systematic review was conducted on the use of lithium in children and adolescents with bipolar disorder (BD). Read More

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http://dx.doi.org/10.1016/j.eurpsy.2018.07.012DOI Listing
October 2018
10 Reads

[Renal complications of lithium use: to cease or to continue?]

Ned Tijdschr Geneeskd 2018 May 29;162. Epub 2018 May 29.

GGZ inGeest, Amsterdam.

Lithium is the most effective maintenance therapy for patients with bipolar disorder. Important renal adverse effects of chronic lithium use include nephrogenic diabetes insipidus (prevalence circa 20%) and chronic kidney disease (prevalence circa 10-20% after 5-9 years of lithium use). Chronic lithium use is linked with slowly progressive chronic kidney disease, though it rarely leads to end-stage renal failure (prevalence of 0. Read More

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May 2018
65 Reads

Glycosuria amount in response to hyperglycaemia and risk for diabetic kidney disease and related events in Type 1 diabetic patients.

Nephrol Dial Transplant 2019 10;34(10):1731-1738

Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat Hospital, DHU FIRE, Department of Diabetology, Endocrinology and Nutrition, Paris, France.

Background: Hyperglycaemia impairs tubulo-glomerular feedback. We tested whether variable tubulo-glomerular feedback during hyperglycaemia contributes to renal risk heterogeneity seen in Type 1 diabetes.

Methods: During the period 1990-92, we studied the tubulo-glomerular feedback in Type 1 diabetic patients at high or low renal risk [21 of 54 with glomerular hyperfiltration and/or microalbuminuria against 11 of 55 with normal glomerular filtration rate (GFR) and urinary albumin despite uncontrolled diabetes]. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ndt/gfy197DOI Listing
October 2019
10 Reads

The effect of lithium on the progression-free and overall survival in patients with metastatic differentiated thyroid cancer undergoing radioactive iodine therapy.

Clin Endocrinol (Oxf) 2018 10 13;89(4):481-488. Epub 2018 Aug 13.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Objective: Pretreatment with lithium (Li) is associated with an increased residence time of radioactive iodine (RAI) in differentiated thyroid cancer (DTC) metastases. There are no data translating this observation into long-term outcomes. The study goal was to compare the efficacy of three methods of preparation for RAI therapy in metastatic DTC-thyroid hormone withdrawal (THW), THW with pretreatment with Li (THW+Li), and recombinant human TSH (rhTSH). Read More

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http://doi.wiley.com/10.1111/cen.13806
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http://dx.doi.org/10.1111/cen.13806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138537PMC
October 2018
29 Reads

The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature.

Curr Drug Metab 2018 ;19(8):653-662

Department of Psychiatry, School of Medicine, Dokuz Eylul University, Izmir, Turkey.

Background: The incidence and mortality rates of cancer in patients with Bipolar Disorder (BD) is higher compared with the general population. The role of Lithium (Li) in cancer proliferation/inhibition is still a controversial issue in the literature.

Objective: Based on a clinical case with lithium intake and development of a renal tumor, we aimed to explore the relationship between Li use and tumor proliferation, with regard to the mechanism of action of Li. Read More

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http://www.eurekaselect.com/161666/article
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http://dx.doi.org/10.2174/1389200219666180430095933DOI Listing
November 2018
14 Reads