6,655 results match your criteria Liposarcoma Imaging


Recurrent Retroperitoneal Liposarcoma: a Case Report and Literature Review.

Indian J Surg Oncol 2018 Dec 19;9(4):640-643. Epub 2018 May 19.

Department of Surgical Oncology, Vikram Hospital, Bangalore, India.

This is a case report of a 61-year-old male patient, presented with fifth recurrence of retroperitoneal liposarcoma and operated for six times. Literature review on retroperitoneal liposarcoma biology, recurrence pattern, role of surgery in primary tumor, and recurrent tumor, adjuvant therapy, role of multivisceral resection, and palliative surgery. Read More

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December 2018

Massive Localized Lymphedema, an Emerging Problem and a Challenging Pseudosarcomatous Condition Mimicking Liposarcoma.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Colorado Denver School of Medicine, 80206 Denver, USA.

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December 2018
1 Read

MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Pathology.

The distinction of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) from its benign counterpart, lipoma, may represent a challenge. MDM2 DNA amplification is used as the gold standard as MDM2 immunohistochemistry lacks specificity and sensitivity. Herein, we investigate the diagnostic utility of MDM2 RNA in situ hybridization (RNA-ISH) and compare the test with MDM2 immunohistochemistry and MDM2 DNA fluorescence in situ hybridization (FISH) in benign and malignant lipomatous neoplasms. Read More

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December 2018
5 Reads

Retroperitoneal dedifferentiated liposarcoma.

Intern Emerg Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Internal Medicine, Complexo Hospitalario Universitario A Coruna, As Xubias 84, 15006, A Coruna, Spain.

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December 2018

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis.

J Transl Med 2018 Dec 5;16(1):338. Epub 2018 Dec 5.

Department of Surgery Oncology and Gastroenterology, University of Padova, Padua, Italy.

Background: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis of patients with soft tissue sarcoma.

Patients And Methods: We considered the 14 single nucleotide polymorphisms (SNPs) of 6 core circadian genes that have a minor allele frequency > 5% and that are known to be associated with cancer risk or prognosis. Read More

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December 2018

Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy.

Sarcoma 2018 1;2018:8029157. Epub 2018 Nov 1.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

Introduction: Myxoid liposarcoma (MLS) is a subtype of liposarcoma characterized morphologically by lipomatous differentiation with a myxoid stroma. The purpose of this study was to review clinical and pathological information for patients treated for MLS at our institution to better understand neoadjuvant and adjuvant therapy.

Materials And Methods: An institutional database of sarcomas was queried for patients who were treated for MLS at our institution between 1992 and 2013. Read More

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November 2018
4 Reads

Case reports of diagnostic error: liposarcoma mistaken for hematoma in an obese female with concurrent ipsilateral thrombosis on rivaroxaban.

Diagnosis (Berl) 2018 Dec 4. Epub 2018 Dec 4.

Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

We report the case of a morbidly obese 49-year-old female found to have a 16×14×10 cm high grade myxoid liposarcoma of the thigh initially diagnosed as a hematoma. Recent initiation of rivaroxaban for a coincident ipsilateral popliteal vein thrombosis placed hematoma high in the differential diagnosis. Despite its large size, the mass was not directly appreciable on physical exam due to excess adjacent adipose tissue. Read More

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December 2018

Rapidly growing pleural liposarcoma masquerading as extrapleural hematoma.

Thorac Cancer 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Intrathoracic liposarcoma can occur in the lung, mediastinum, pleura, and chest wall, and tends to remain clinically silent until becoming large enough to displace adjacent structures. Treatment usually includes sufficient surgical resection followed when necessary by adjuvant chemoradiotherapy. We report a case of an uncommon presentation of a rapidly growing pleural liposarcoma, the diagnosis of which may have been obscured by coexisting thoracic trauma with suspected extrapleural hematoma. Read More

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December 2018

Primary small bowel mesentery de-differentiated liposarcoma causing torsion with no recurrence for 5 years: A case report and review of the literature.

Medicine (Baltimore) 2018 Nov;97(48):e13446

Department of General and Gastroenterological Surgery, Osaka Medical College, Daigaku-machi, Takatsuki.

Rationale: Liposarcoma (LPS) is a rare malignant soft-tissue tumor. Management of LPS is relatively difficult, because there are no characteristic symptoms, or biomarkers, nor any established effective treatment. Hence, the report of the accumulation of each LPS case is necessary. Read More

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November 2018
3 Reads

Retroperitoneal Liposarcoma Masquerading As An Impending Rupture of Inflammatory Abdominal Aortic Aneurysm.

Ann Vasc Surg 2018 Nov 26. Epub 2018 Nov 26.

5(th) Department of Surgery, Medical School, Aristotle University of Thessaloniki, Hippocratio Hospital, Thessaloniki, Greece.

Background: We present a unique case scenario of a periaortic liposarcoma masquerading as an impending rupture of an inflammatory abdominal aortic aneurysm (AAA).

Case Report: A 57-year-old man was referred to our unit for an emergency endovascular repair of "an inflammatory AAA with CT features of impending rupture". He underwent an uneventful endovascular repair with a bifurcated endograft (C3, Gore, Flagstaff, AZ, USA). Read More

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November 2018
3 Reads

Isolated intraosseous extra-gnathic orbital myxoma: a clinicopathologic case report.

Orbit 2018 Nov 29:1-6. Epub 2018 Nov 29.

b Department of Pathology, Majumdar Shaw Cancer Center , Narayana Health City , Bangalore , India.

A 19-year-old female student presented with painless, progressive proptosis in the right eye for the past six months causing significant cosmetic blemish and double vision. Clinical evaluation revealed normal visual acuity, normal pupillary reflex, severe proptosis, and dystopia. Orbital imaging revealed a heterogeneous mass in superior orbit displacing the globe inferiorly and causing extensive bony erosion of frontal bone superiorly and invading the frontal sinus. Read More

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November 2018
1 Read

A comprehensive review of the current evidence for trabectedin in advanced myxoid liposarcoma.

Cancer Treat Rev 2018 Nov 15;72:37-44. Epub 2018 Nov 15.

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France.

Myxoid liposarcoma (MLS) is a rare mesenchymal tumor that constitutes 10-20% of all liposarcomas. MLS is a translocation-related sarcoma (TRS) related to the chromosomal translocation t(12:16) (q13:p11), producing the FUS-CHOP oncoprotein that constitutes one of the main targets of trabectedin in MLS patients. It is known to be chemosensitive namely to trabectedin in contrast to other soft tissue sarcomas. Read More

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November 2018
1 Read

Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis.

Phytomedicine 2018 Dec 11;51:162-170. Epub 2018 Oct 11.

Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, Austria.

Background: During a screening of Chinese plants traditionally used for the treatment of cancer and related diseases, extracts of the root bark of Periploca sepium Bunge showed strong cytotoxic activity.

Purpose: Isolate and identify cytotoxic compounds from P. sepium and investigate the effects and mechanism of action on different cancer cell lines. Read More

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December 2018
4 Reads

Massive Localized Lymphedema in an Unreported Location (Retroperitoneum).

Diagn Pathol 2018 Nov 20;13(1):89. Epub 2018 Nov 20.

Department of Pathology, Koc University School of Medicine, Topkapi / Zeytinburnu, 34010, Istanbul, Turkey.

Background: Massive localized lymphedema (MLL) is a non-neoplastic benign soft tissue lesion that may be confused with sarcomas or other neoplastic proliferations both clinically and morphologically. Most occur in morbidly obese adults on the lower extremities. The objective of this article is to document a case of MLL in the retroperitoneal cavity which is a previously unreported site for this lesion, and to highlight its unusual clinical features. Read More

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November 2018
3 Reads

Establishment of a Novel PDX Mouse Model and Evaluation of the Tumor Suppression Efficacy of Bortezomib Against Liposarcoma.

Transl Oncol 2018 Nov 14;12(2):269-281. Epub 2018 Nov 14.

Department of Health Sciences & Technology, Graduate School, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul; Transplantation Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

The patient-derived xenograft (PDX) model has been adopted as a major tool for studying tumorigenesis and differentiation in various carcinomas. In addition, it has been used in the development of anticancer agents. PDX models have been among the most meaningful tools used to understand the role of stromal cells and vascular cells in the body, which are major factors in cancer development and the application of therapeutic agents. Read More

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November 2018
2 Reads

Solitary pancreatic metastasis of extremity myxoid liposarcoma: a case report and literature review.

BMC Cancer 2018 Nov 16;18(1):1121. Epub 2018 Nov 16.

Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

Background: Myxoid liposarcoma has a distinct migration aptitude; however, pancreatic metastasis is rare.

Case Presentation: We report on the case of a 40-year-old female patient who suffered solitary pancreatic metastasis of myxoid liposarcoma and had a right thigh myxoid liposarcoma radical resection 5 years ago. The patient underwent a medial pancreatectomy and pancreaticojejunostomy for solitary pancreatic metastasis of myxoid liposarcoma. Read More

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November 2018

Concurrent Congenital Fibrolipomatous Hamartoma and Congenital Nevus of Infancy: A Syndromic or Chance Association.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):219-221

Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital nevi and fibrolipomatous hamartoma are benign tumors of childhood, the latter being very uncommon. Fibrous hamartoma of infancy typically occurs in <2 years of life. The concurrence of these two lesions is extremely rare. Read More

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November 2018
1 Read

Resection of Abdominal, Pelvic and Retroperitoneal Tumors.

Klin Onkol 2018 ;31(3):230-234

Background: Mesenchymal malignancies are relatively rare tumors with distinct behaviors that are usually surgically removal. However, it is sometimes impossible to perform such surgery according to standardized procedures. In particular, surgical removal of intraperitoneal and retroperitoneal tumors differs among individuals. Read More

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January 2018
6 Reads

The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas.

Cancers (Basel) 2018 Nov 14;10(11). Epub 2018 Nov 14.

INSERM U1218, F-33076 Bordeaux, France.

By inhibiting Insulin-Like Growth Factor-1-Receptor (IGF-1R) signaling, Klotho (KL) acts like an aging- and tumor-suppressor. We investigated whether impacts the aggressiveness of liposarcomas, in which IGF-1R signaling is frequently upregulated. Indeed, we observed that a higher expression in liposarcomas is associated with a better outcome for patients. Read More

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November 2018
4 Reads

Giant exophytic renal angiomyolipoma masquerading as a retroperitoneal liposarcoma: A case report and review of literature.

World J Clin Oncol 2018 Nov;9(7):162-166

Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi 110095, India.

A 42-years-old lady, presented with a large retroperitoneal mass which was preoperatively diagnosed as a retroperitoneal liposarcoma following an image guided core biopsy. She underwent a margin-negative resection of the retroperitoneal mass (multi visceral resection - enbloc excision of the retroperitoneal mass with a left nephrectomy and a segmental descending colectomy). The final histopathological examination of the resected specimen confirmed an exophytic renal angiomyolipoma (AML) which was extending into the retroperitoneum. Read More

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November 2018
1 Read

Prognostic significance of pretreatment lymphocyte/monocyte ratio in retroperitoneal liposarcoma patients after radical resection.

Cancer Manag Res 2018 18;10:4727-4734. Epub 2018 Oct 18.

Department of Bone and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China,

Background: The aim of this study was to evaluate the prognostic value of pretreatment inflammatory biomarkers in retroperitoneal liposarcoma (RPLS) patients after radical resection.

Patients And Methods: One hundred patients with RPLS who underwent radical resection between September 2004 and October 2010 at Fudan University Shanghai Cancer Center were included in this study. Laboratory tests of peripheral blood were sampled before surgery. Read More

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October 2018
1 Read

Influence of age and subtype in outcome of operable liposarcoma.

Radiol Med 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Largo Brambilla 3, 50141, Florence, Italy.

Aim: Liposarcoma (LPS) is rare tumor deriving from adipocytes. LPS is classified into histological subtypes: well-differentiated (WDLPS), dedifferentiated (DDLPS), myxoid (MLPS) and pleomorphic (PLPS). A tailored approach taking into account the specificity of disease subtype and age at presentation could be helpful in delineating therapeutic management of liposarcoma. Read More

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November 2018
3 Reads

Amplification of DNA damage-inducible transcript 3 (DDIT3) is associated with myxoid liposarcoma-like morphology and homologous lipoblastic differentiation in dedifferentiated liposarcoma.

Mod Pathol 2018 Nov 12. Epub 2018 Nov 12.

Department of Pathology, University of New Mexico, Albuquerque, NM, USA.

Dedifferentiated liposarcoma is defined as progression of atypical lipomatous tumor/well-differentiated liposarcoma to a higher grade usually non-lipogenic sarcoma, with amplification of 12q13-15. This region contains several genes involved in liposarcoma pathogenesis, including MDM2, CDK4, and DDIT3. While the former two are thought of as the main drivers in dedifferentiated liposarcoma, DDIT3 is typically rearranged in myxoid liposarcoma. Read More

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November 2018
13 Reads

Dedifferentiated liposarcoma of the gallbladder: first reported case.

World J Surg Oncol 2018 Nov 12;16(1):221. Epub 2018 Nov 12.

Department of Surgery, Federal University of Pernambuco, Recife, PE, Brazil.

Background: Liposarcoma of the gallbladder is an extremely rare sarcoma, with only five cases reported in the literature according to our knowledge.

Case Presentation: A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice. Abdominal ultrasonography and computed tomography (CT) evidenced an extensive gallbladder lobular formation adhered to the inferior border of the right hepatic lobe and cholelithiasis. Read More

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November 2018
5 Reads

SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells.

J Pharmacol Sci 2018 Oct 24. Epub 2018 Oct 24.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:

Frequent local recurrence and metastasis are generally involved in human liposarcoma, but the management is a challenge. There is an urgent need for improved effective therapy. In the present study, we reported that SBF-1, a steroidal glycoside, inhibited the growth of cultured highly malignant human liposarcoma SW872-S cells in vitro and in vivo. Read More

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October 2018
4 Reads
2.360 Impact Factor

Retroperitoneal dedifferentiated liposarcoma: Analysis of 61 cases from a large institution.

J Cancer 2018 5;9(21):3831-3838. Epub 2018 Oct 5.

Department of Bone and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai, China.

: To describe the clinical features of retroperitoneal dedifferentiated liposarcoma (RP DDLS) and further evaluate the prognostic factors. : The clinicopathological variables and treatment strategies of 61 RP DDLS patients who underwent surgical resections at a single institution between September 2005 and September 2016 were reviewed. Kaplan-Meier and Cox regression methods were conducted for survival analyses. Read More

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October 2018
3 Reads

Status of programmed death-ligand 1 expression in sarcomas.

J Transl Med 2018 Nov 6;16(1):303. Epub 2018 Nov 6.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea.

Background: Sarcomas are challenging to study because of their rarity and histomorphological complexity. PD1 and PD-L1 inhibitors showed a promising anti-tumor effect in solid tumors, where a relationship between PD-L1 expression and the objective response has been evidenced.

Methods: In this study, we examined PD-L1 expression in 16 bone and soft tissue sarcoma cell lines of 11 different subtypes by means of western blot, flow cytometry and immunocytochemistry, and in 230 FFPE patient-derived tumor tissues by means of immunohistochemistry using three different antibody clones. Read More

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November 2018
5 Reads

Management of locoregional recurrence after radical resection of a primary nonmetastatic retroperitoneal soft tissue sarcoma: The Gustave Roussy experience.

J Surg Oncol 2018 Dec 6;118(8):1318-1325. Epub 2018 Nov 6.

Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Despite surgery, many patients experience locoregional recurrence (LR), the optimum treatment of which is still debated.

Methods: All 297 consecutive patients operated for a nonmetastatic primary retroperitoneal soft tissue sarcoma (RPS) between 1994 and 2017 were retrospectively analyzed to report our experience in treating LR.

Results: After a median follow-up of 97 months, 55 patients (19%) developed LR. Read More

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December 2018
6 Reads

Atypical lipomatous tumor in the ligamentum teres of liver: A case report and review of the literature.

World J Clin Cases 2018 Oct;6(12):548-553

Department of Gastroenterology, Kanazawa Medical University Himi Municipal Hospital, Himi-shi, Toyama-ken 935-8531, Japan.

A 61-year-old male was referred to our hospital with a three-month history of persistent epigastralgia and right hypochondralgia. Initial examination revealed a fist-size mass at the epigastric fossa. Ultrasonography showed a hemangioma and a mosaic echoic lesion in the ventromedian with poor blood-flow signal and linear hyperechoic part inside, and a clear border to the surroundings. Read More

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October 2018
7 Reads

Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.

Biochem Biophys Res Commun 2018 Dec 2;506(4):912-917. Epub 2018 Nov 2.

AntiCancer, Inc, San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA. Electronic address:

Liposarcoma is the most common type of soft tissue sarcoma. Among the subtypes of liposarcoma, dedifferentiated liposarcoma (DDLPS) is recalcitrant and has the lowest survival rate. The aim of the present study is to determine the efficacy of metabolic targeting with recombinant methioninase (rMETase) combined with palbociclib (PAL) against a doxorubicin (DOX)-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model. Read More

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December 2018
13 Reads

Liposarcoma of the uterine corpus: A case report and literature review.

Gynecol Oncol Rep 2018 Nov 22;26:78-81. Epub 2018 Oct 22.

Department of Obstetrics and Gynecology, Dokkyo Medical University, Japan.

Liposarcoma of the uterine corpus is extremely rare. We performed a laparotomy on a 55-year-old woman with the complaints of abdominal distension and genital bleeding who was found to have a uterine tumor, 17 × 16 cm in diameter. The preoperative diagnosis was a lipoma or lipoleiomyoma of the uterine corpus. Read More

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November 2018
1 Read

Impact of perioperative chemotherapy and radiotherapy in patients with primary extremity soft tissue sarcoma: retrospective analysis across major histological subtypes and major reference centres.

Eur J Cancer 2018 Dec 29;105:19-27. Epub 2018 Oct 29.

Department of Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy. Electronic address:

Background: The role of radiotherapy (RTx) and chemotherapy (CTx) in primary extremity soft tissue sarcoma (eSTS) patients is not precisely defined.

Methods: All consecutive primary eSTS patients treated within three European and one North American reference centres in a 20-year time span were included. The tendency to perform chemotherapy/radiotherapy (CTx/RTx) was explored using multivariable binary logistic models. Read More

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December 2018
5 Reads

[A Case Report of Retroperitoneal Liposarcoma Resected Six Times for 16 Years].

Gan To Kagaku Ryoho 2018 Oct;45(10):1507-1509

Dept. of Surgery, Yokohama City University.

We report of a long-surviving patient with retroperitoneal liposarcoma that required 6 surgeries in 16 years. A 62-year-old man was diagnosed with liposarcoma, which was first excised in 2001. Thereafter, we excised recurrences in the retroperitoneum with the left kidney in February 2004. Read More

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October 2018

Well-Differentiated Liposarcoma Localized to the Thyroid Gland.

Eur Thyroid J 2018 Oct 19;7(5):262-266. Epub 2018 Jul 19.

Department of Otolaryngology - Head and Neck Surgery, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA.

Liposarcoma of the thyroid gland is a pathology that is rarely encountered in clinical practice, given the paucity of these cases. For the same reason, a definite treatment protocol has not been established for these cases. We present a case of a 49-year-old man who presented with a thyroid mass that was found to be a well-differentiated liposarcoma and was treated surgically with no adjuvant therapy other than close surveillance with clinical examination and MRI scans. Read More

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October 2018
4 Reads

Anastomosing haemangioma with fatty changes in the perirenal space: a lesion mimicking liposarcoma.

BJR Case Rep 2018 1;4(2):20170022. Epub 2017 Nov 1.

Department of Diagnostic Radiology, Institute of Biomedical and Health Sciences,Hiroshima University, Minami-ku, Hiroshima, Japan.

Anastomosing haemangioma is a rare subtype of capillary haemangioma. Pathologically, anastomosing haemangioma presents with anastomosing sinusoidal capillary-sized vessels in an architecture reminiscent of the splenic parenchyma. Its anastomosing architecture pathologically can lead to concern for angiosarcoma. Read More

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November 2017
1 Read

Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters.

Curr Treat Options Oncol 2018 Oct 25;19(12):64. Epub 2018 Oct 25.

Department of Internal Medicine, Division of Medical Oncology, Washington University School of Medicine, Box 8076 660 S. Euclid Avenue, St. Louis, MO, 63110, USA.

Opinion Statement: Sarcomas are a heterogeneous group of rare malignancies that arise from mesenchymal cells and can occur anywhere in the body. Herein, the focus will be on one subtype of sarcoma that arises from adipocytic tissue, liposarcoma. Specifically, the review will focus on one type of liposarcoma, myxoid liposarcoma. Read More

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October 2018
8 Reads

Primary anatomical site, adjuvant therapy, and other prognostic variables for dedifferentiated liposarcoma.

J Cancer Res Clin Oncol 2018 Oct 25. Epub 2018 Oct 25.

Division of Hematology/Oncology, Department of Internal Medicine, Creighton University Medical Center, Omaha, NE, USA.

Background: Dedifferentiated liposarcoma (DDLPS) is a high-grade, clinically aggressive tumor associated with low survival probabilities. Prognostic variables for DDLPS have not been previously reported in a large patient population.

Methods: A total of 3573 patients with primary DDLPS were analyzed from the National Cancer Data Base (NCDB). Read More

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October 2018
3 Reads

Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features.

Diagn Cytopathol 2018 Nov 24;46(11):950-957. Epub 2018 Oct 24.

Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.

Background: Extraskeletal myxoid chondrosarcoma (EMC) is a tumor of uncertain differentiation. Few data are available regarding its cytomorphological features in fine-needle aspiration (FNA). Specific cytogenetic alterations involving the NR4A3 gene are found in EMC and can be identified in FNA samples. Read More

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November 2018
1 Read

[What is the best management for a spermatic cord sarcoma in 2018?]

Prog Urol 2018 Oct 16. Epub 2018 Oct 16.

Service de chirurgie, institut Curie, 26, rue d'Ulm, 75248 Paris, France.

Spermatic cord sarcomas are rare tumors for which the most important is the initial diagnostic procedure. They are frequently misdiagnosed after surgery for inguinal hernia, inguinal lymphadenectomy or testicular malignancy. Any clinical suspicion has to lead to perform imaging with MRI and a core needle biopsy in order to obtain an accurate preoperative diagnosis. Read More

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October 2018
7 Reads

Subclassification of pleomorphic sarcomas: How and why should we care?

Authors:
Jason L Hornick

Ann Diagn Pathol 2018 Oct 11;37:118-124. Epub 2018 Oct 11.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Pleomorphic sarcomas are a heterogeneous group of mesenchymal neoplasms with widely varied clinical behavior but overlapping histologic appearances. The following guidelines are helpful when approaching the diagnosis of a pleomorphic sarcoma. (1) Be aware of the relative incidence of the various sarcoma types: several pleomorphic sarcomas are relatively common (e. Read More

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October 2018
3 Reads

Giant primary liposarcoma of the anterior mediastinum: A case report.

Medicine (Baltimore) 2018 Oct;97(42):e12873

Department of Thoracic Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai, China.

Rationale: Liposarcoma is a cancerous mesenchymal tumor and the most common soft-tissue sarcoma that starts in the adipose tissue. Liposarcoma is commonly found in lower extremities and retroperitoneum, but rarely occurs in the mediastinum.

Patient Concerns: A 63-year-old male was referred to our clinic with a 6-month history of chronic cough and dyspnea. Read More

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October 2018
4 Reads

Primary mediastinal dedifferentiated liposarcoma: Five case reports and a review.

Thorac Cancer 2018 Dec 17;9(12):1733-1740. Epub 2018 Oct 17.

Department of Laboratory Medicine, Shinshu University, Matsumoto, Japan.

Background: Liposarcoma has been subclassified histologically into well-differentiated, myxoid, pleomorphic, and dedifferentiated types. The dedifferentiated type generally shows poorer prognosis than the well-differentiated type. Because of its rarity, the clinicopathological features and clinical outcomes of primary mediastinal dedifferentiated liposarcoma remain unclear. Read More

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December 2018
1 Read

Trabectedin for Advanced Soft Tissue Sarcoma: Ten Year Real-Life Perspective.

Isr Med Assoc J 2018 Oct;20(10):599-603

Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Trabectedin is a marine-derived chemotherapy, which has received U.S. Food and Drug Administration approval for use in anthracycline-resistant advanced soft tissue sarcoma (STS), especially liposarcoma and leiomyosarcoma (L-sarcomas). Read More

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October 2018
2 Reads

Laparoscopic resection of large pelvic lipoma causing obstructive uropathy in a 66 year old female - A case report from Greece.

J Pak Med Assoc 2018 Sep;68(9):1400-1402

Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Lipomas are benign, usually asymptomatic, tumours and pelvic lipomas are extremely rare. We describe the case of a giant pelvic lipoma causing obstructive uropathy to a 66-year-old morbidly obese female treated in the 4th Surgical Department of the Medical School of Aristotle University of Thessaloniki in General Hospital "G. Papanikolaou" in March 2016. Read More

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September 2018
1 Read

Comprehensive Bioinformatic Analysis Genes Associated to the Prognosis of Liposarcoma.

Med Sci Monit 2018 Oct 14;24:7329-7339. Epub 2018 Oct 14.

Department of Osteology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).

BACKGROUND Liposarcoma is the most common type of soft tissue sarcoma, but its molecular mechanism is poorly defined. This study aimed to identify genes crucial to the pathogenesis of liposarcoma and to explore their functions, related pathways, and prognostic value. MATERIAL AND METHODS Differentially expressed genes (DEGs) in the GSE59568 dataset were screened. Read More

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October 2018
6 Reads

Massive retroperitoneal dedifferentiated liposarcoma in a young patient.

J Surg Case Rep 2018 Oct 8;2018(10):rjy272. Epub 2018 Oct 8.

PGY4 Resident General Surgery, P.U.C.E., Quito, Ecuador.

Liposarcomas are rare malignant tumors that mostly develop in the retroperitoneum. They have a broad behavioral spectrum, from small masses of tissue to highly aggressive tumors. The dedifferentiation process occurs in up to 10% and it's most likely to occur in the retroperitoneum, a process that not only changes its components but also its prognosis. Read More

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October 2018

Giant myxoid liposarcoma of the gluteal region: case report of patient caused delay of surgical treatment and review of the literature.

J Surg Case Rep 2018 Oct 8;2018(10):rjy265. Epub 2018 Oct 8.

Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.

Although adult soft tissue sarcoma is a rare disease, it needs individual treatment by an experienced, interdisciplinary team. We present an exceptional case of a 36-year-old woman suffering from a giant intermediate grade myxoid liposarcoma of the left buttock. She had been seen 4 years earlier but refused to undergo any treatment by then. Read More

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October 2018

Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.

World J Surg Oncol 2018 Oct 11;16(1):203. Epub 2018 Oct 11.

University of Maryland, Greenebaum Cancer Center, South Greene Street Suite 9d10 Baltimore, Baltimore, MD, 21201, USA.

Background: Retroperitoneal soft tissue sarcomas (STS) include a number of histologies but are rare, with approximately 3000 cases in the USA per year. Retroperitoneal STS have a high incidence of local and distant recurrence. The purpose of this study was to review the University of Maryland Medical Center's (UMMC) treatment experience of retroperitoneal STS, where the patient population served represents a diverse socioeconomic and ethnic catchment. Read More

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October 2018
2 Reads

Coexistence of gastric gastrointestinal stromal tumor, intro-abdominal and retroperitoneal liposarcomas -a case report.

BMC Cancer 2018 Oct 11;18(1):968. Epub 2018 Oct 11.

Department of Nephrology, Yancheng City No.1 people's hospital, Yancheng, Jiangsu Province, 224005, China.

Background: Gastric gastrointestinal stromal tumor (GIST), intro-abdominal and retroperitoneal neoplasms are distinct tumors arising from different cell layers; therefore, coexistence of such tumors is relatively rare.

Case Presentation: A man complained of early satiety for 2 mouths, whose upper gastrointestinal (GI) endoscopy showed a tumor arising from the greater curvature of gastric body and extending into the lumen. Abdominal computed tomography (CT) revealed coexistence of gastric, intro-abdominal and retroperitoneal masses. Read More

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October 2018
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