1,976 results match your criteria Liposarcoma Imaging

Dedifferentiated liposarcoma (DDLPS) in the rectum: A case report.

J Int Med Res 2022 Jun;50(6):3000605221102081

Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Dedifferentiated liposarcoma (DDLPS) is a rare subtype of liposarcoma with a poor prognosis. This current case report describes a rectal DDLPS in a 68-year-old Chinese male that presented with lower abdominal pain and weight loss. Computed tomography and magnetic resonance imaging were undertaken to evaluate the tumour. Read More

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Pelvic soft tissue sarcomas.

Eur J Surg Oncol 2022 Jun 4. Epub 2022 Jun 4.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

Pelvic soft tissue sarcomas (PSTS) are a rare, heterogeneous group of tumors. They have been usually analyzed with retroperitoneal sarcomas (RPS), but actually have key differences. Due to their unique anatomic location, symptomatic presentation of PSTS may be more common than RPS. Read More

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The Role of Preoperative F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Retroperitoneal Sarcoma.

Front Oncol 2022 30;12:868823. Epub 2022 May 30.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) was used to predict pathologic grades based on the maximum standardized uptake value (SUVmax) in soft tissue sarcoma and bone sarcoma. In retroperitoneal sarcoma (RPS), the effectiveness of PET was not well known. This study was designed to investigate the association of SUVmax with histopathologic grade and evaluate the usefulness of F-FDG PET/CT before operation. Read More

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Can homogeneous, lipomatous tumors be primarily resected without biopsy? A retrospective analysis of 240 tumors.

World J Surg Oncol 2022 Jun 8;20(1):184. Epub 2022 Jun 8.

Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: According to guidelines, every soft tissue tumor (STT) larger than 3 cm should be biopsied before definitive resection. Advances in magnetic resonance imaging (MRI) improve the possibility to give a provisional diagnosis of the tumor's entity. Can lipomas and atypical lipomatous tumors (ALTs) of the extremities therefore be primarily marginally resected based on interpretation of MR images without a previous biopsy?. Read More

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Imaging of soft tissue sarcomas of the extremities with radiologic-pathologic correlation.

Curr Probl Diagn Radiol 2022 May 2. Epub 2022 May 2.

Department of Radiology, Temple University Health System, 3401 N. Broad St, Philadelphia, PA 19140, United States.

Soft tissue sarcomas are a rare diverse group of mesenchymal malignancies that can arise in any location in the body and have extremely variable presentations. Liposarcoma, pleomorphic undifferentiated sarcoma, leiomyosarcoma, myxofibrosarcoma, and synovial sarcoma constitute 75% of all soft tissue sarcomas. These along with more uncommon sarcomas will be reviewed with emphasis on the 2013 World Health Organization (WHO) classification. Read More

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Hydrocele with Paratesticular Liposarcoma.

J Coll Physicians Surg Pak 2022 Apr;32(4):S1-S2

Department of Urology, Medical Faculty, Karabuk University, Karabuk, Turkey.

Paratesticular liposarcoma (PLS) is a rare type of genitourinary malignancy in the spermatic cord presenting as scrotal swelling. In this case study, we report an 82-year male who presented with prolonged left scrotal swelling and pain that did not respond to analgesic treatment for one week. His ultrasound confirmed increased fluid content in the left scrotal compartment in the form of septated hydrocele, and hydrocelectomy was planned. Read More

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Lipomatous Tumors: A Comparison of MRI-Reported Diagnosis with Histological Diagnosis.

Diagnostics (Basel) 2022 May 21;12(5). Epub 2022 May 21.

Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Lipomatous tumors are among the most common soft tissue tumors (STTs). Magnetic resonance imaging (MRI) is a state-of-the-art diagnostic tool used to differentiate and characterize STTs. Radiological misjudgment can lead to incorrect treatment. Read More

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Chondroid Lipoma Mimicking Malignancy.

J Belg Soc Radiol 2022 5;106(1):40. Epub 2022 May 5.

AZ Sint-Maarten and Catholic University of Leuven, BE.

A chondroid lipoma is a rare benign adipocytic neoplasm, containing a chondromyxoid matrix, that may mimic a myxoid liposarcoma and myxoid chondrosarcoma. Read More

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Totally laparoscopic colectomy with intracorporeal anastomosis for colonic liposarcoma: A case report.

Asian J Endosc Surg 2022 May 20. Epub 2022 May 20.

Department of Surgery, Okayama City Hospital, Okayama, Japan.

Liposarcoma is a type of soft tissue sarcoma. Primary colonic liposarcomas are extremely rare. An 86-year-old man with diarrhea and anorexia visited our outpatient clinic at Okayama City Hospital. Read More

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CT imaging of an unusual malignant inguinal mass: metastatic parafunicular dedifferentiated liposarcoma.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola-Malpighi, Bologna, Emilia-Romagna, Italy.

A man in his 50s was redirected by his general practitioner to our University Hospital for a radiological evaluation after the complaint of a left inguinal swelling. The preliminary ultrasound and CT scan showed a left parafunicolar mass located between the root of the penis and the spermatic cord. The lesion was biopsied shortly after and histologically diagnosed as a dedifferentiated liposarcoma. Read More

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Giant retroperitoneal well-differentiated liposarcoma presenting in emergency with intestinal occlusion: Case report and review of the literature.

Int J Surg Case Rep 2022 Jun 3;95:107152. Epub 2022 May 3.

General Surgery Department, San Salvatore Hospital, Paternò (Catania), Italy.

Introduction And Importance: Liposarcoma (LPS) represents the most common type of retroperitoneal sarcoma (RPS) and can be classified into four subtypes. Preoperative diagnosis of retroperitoneal liposarcoma (RLPS) is a challenge because of its late and nonspecific clinical presentation. Imaging may be helpful for determining the correct diagnosis. Read More

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Case Report: Retroperitoneal Sarcoma in Six Operations: Our Experience in Operative Management of Blood Vessels.

Front Oncol 2022 28;12:885033. Epub 2022 Apr 28.

Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.

Here we introduce a case of retroperitoneal liposarcoma, which is characterized by repeated recurrences after surgery, and has undergone a total of 6 operations. The diameter of the tumor was about 26 cm at the time of the patient's diagnosis. The imaging examination revealed that the surrounding organs and blood vessels were invaded, which brought great challenges to radical resection. Read More

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Safety and effectiveness of eribulin in Japanese patients with soft tissue sarcoma including rare subtypes: a post-marketing observational study.

BMC Cancer 2022 May 11;22(1):528. Epub 2022 May 11.

Department of Musculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center Hospital, Rare Cancer Center, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Background: Soft tissue sarcomas (STSs) are a heterogeneous group of cancers with over 100 described subtypes. While these cancers are infrequent, the prognosis is quite poor, particularly for those with stage IV metastatic disease. Patients for whom curative resection is difficult or those with recurrent metastatic disease are treated with chemotherapy, although the options are very limited. Read More

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Myxoid liposarcoma metastatic to the mandible: First case report and review of the literature.

Oral Oncol 2022 Jun 4;129:105900. Epub 2022 May 4.

Department of Oral Pathology, Seoul National University Dental Hospital, Seoul, Republic of Korea; Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address:

Unlike other soft tissue sarcomas, myxoid liposarcoma tends to metastasize to bone even before developing lung metastases. In this report, we present a unique case of myxoid liposarcoma metastatic to the mandible. A 40-year-old male who had a history of myxoid liposarcoma in the buttock presented with paresthesia in the left lower face and mandible. Read More

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BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity.

PLoS One 2022 4;17(5):e0266980. Epub 2022 May 4.

SOTIO Biotech Inc.

Purpose: The solid tumor microenvironment (TME) drives T cell dysfunction and inhibits the effectiveness of immunotherapies such as chimeric antigen receptor-based T cell (CAR T) cells. Early data has shown that modulation of T cell metabolism can improve intratumoral T cell function in preclinical models.

Experimental Design: We evaluated GPC3 expression in human normal and tumor tissue specimens. Read More

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Pancreatic liposarcoma: a case report.

Abdom Radiol (NY) 2022 Jun 4;47(6):1912-1916. Epub 2022 May 4.

Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.

An 81-year-old woman who had undergone total thyroidectomy for papillary thyroid cancer 12 years earlier was found to have a tumor in the tail of the pancreas. Four years earlier, skin, lung, and mediastinal lymph node metastases had appeared. Computed tomography (CT) showed a mass 26 mm in diameter in the tail of the pancreas. Read More

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Imaging and Clinical Findings in a Series of Six Cases of Rare Primary Mediastinal Liposarcoma.

Radiol Cardiothorac Imaging 2022 Apr 17;4(2):e210259. Epub 2022 Mar 17.

School of Medicine and Dentistry (G.S.W.), Department of Imaging Sciences (D.B., S.K.H.), Department of Pathology and Laboratory Medicine (I.Y.C., M.J.V.), and Department of Gastroenterology (R.T.), University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642.

Primary mediastinal liposarcoma is a rare, fat-containing malignant lesion that can manifest incidentally with varied imaging appearances. The size and location within the mediastinum can vary among patients. Here, the authors describe the clinical presentation, radiographic characteristics, management, and prognosis in a series of six patients with primary mediastinal liposarcoma. Read More

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Artificial intelligence significantly improves the diagnostic accuracy of deep myxoid soft tissue lesions in histology.

Sci Rep 2022 04 28;12(1):6965. Epub 2022 Apr 28.

Department of Pathology, CUHK Medical Centre, 9 Chak Cheung Street, Shatin, New Territories, HKSAR, Hong Kong.

Deep myxoid soft tissue lesions have posed a diagnostic challenge for pathologists due to significant histological overlap and regional heterogeneity, especially when dealing with small biopsies which have profoundly low accuracy. However, accurate diagnosis is important owing to difference in biological behaviors and response to adjuvant therapy, that will guide the extent of surgery and the need for neo-adjuvant therapy. Herein, we trained two convolutional neural network models based on a total of 149,130 images representing diagnoses of extra skeletal myxoid chondrosarcoma, intramuscular myxoma, low-grade fibromyxoid sarcoma, myxofibrosarcoma and myxoid liposarcoma. Read More

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Discrimination of lipoma from atypical lipomatous tumor/well-differentiated liposarcoma using magnetic resonance imaging radiomics combined with machine learning.

Jpn J Radiol 2022 Apr 17. Epub 2022 Apr 17.

Department of Pathology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.

Purpose: To evaluate the diagnostic capability of radiomics in distinguishing lipoma and Atypic Lipomatous Tumors/Well-Differentiated Liposarcomas (ALT/WDL) with Magnetic Resonance Imaging (MRI).

Materials And Methods: Patients with a histopathologic diagnosis of lipoma (n = 45) and ALT/WDL (n = 20), who had undergone pre-surgery or pre-biopsy MRI, were enrolled. The MDM2 amplification was accepted as gold-standard test. Read More

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Shoulder Lipoblastoma in a 2-Year-Old Boy Case Report and Literature Review.

J Orthop Case Rep 2021 Dec;11(12):84-87

Department of Orthopaedics, Al Razi Hospital, Shuwaikh Area, Kuwait, P.O Box: 4078, 13001, Suffix.

Introduction: Lipoblastoma is a rare mesenchymal benign tumor of the white fat cells that affect mostly infants and children below 3 years old. MLipoblastoma can be found in various locations in the body, however, it is usually located in the extremities, lower extremities in particular.

Case Report: We describe a case of a 2-year-old Middle Eastern boy who has a rare lipoblastoma of his left shoulder that is unusual. Read More

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December 2021

Hibernoma of Thigh: A Case Report of 39-Year-Old Male.

J Orthop Case Rep 2021 Oct;11(10):69-72

Department of Orthopedic, Oncology and Reconstructive Arthroplasty Consultant, King Fahad Medical City, Riyadh, Saudi Arabia.

Introduction: Hibernoma is an uncommon benign lipomatous tumor that originates from residual brown fat. It commonly affects adult patients aged between 30 and 40 with a slight predominance in male more than female and usually seen in the thigh, shoulder, back, chest, axilla, and neck. The present report aimed to highlight on a viable differential diagnosis of thigh mass including liposarcoma and atypical lipoma. Read More

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October 2021

Intrathoracic lipoma of the chest wall that appeared relatively rapidly and could be resected and diagnosed by minimally invasive thoracoscopic surgery: A case report.

Respirol Case Rep 2022 May 7;10(5):e0946. Epub 2022 Apr 7.

Department of Thoracic and Cardiovascular Surgery Wakayama Medical University Wakayama Japan.

The occurrence of lipoma in the thoracic cavity is relatively rare, and it is clinically difficult to distinguish it from liposarcoma. We report a case of intrathoracic lipoma that was pathologically diagnosed and differentiated from liposarcoma after minimally invasive thoracoscopic tumour resection. A 35-year-old male patient without any symptoms was referred to our hospital due to an abnormal shadow on chest x-ray. Read More

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Novel computer aided diagnostic models on multimodality medical images to differentiate well differentiated liposarcomas from lipomas approached by deep learning methods.

Orphanet J Rare Dis 2022 04 7;17(1):158. Epub 2022 Apr 7.

Department of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, China.

Background: Deep learning methods have great potential to predict tumor characterization, such as histological diagnosis and genetic aberration. The objective of this study was to evaluate and validate the predictive performance of multimodality imaging-derived models using computer-aided diagnostic (CAD) methods for prediction of MDM2 gene amplification to identify well-differentiated liposarcoma (WDLPS) and lipoma.

Materials And Methods: All 127 patients from two institutions were included with 89 patients in one institution for model training and 38 patients in the other institution for external validation between January 2012 and December 2018. Read More

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Inverted intercostal hernia of elastofibroma dorsi mimicking well-differentiated liposarcoma in the chest wall.

Acta Radiol Open 2022 Mar 30;11(3):20584601221080514. Epub 2022 Mar 30.

Department of Radiology, Shimane University, Izumo, Japan.

Elastofibroma dorsi is a well-known benign chest wall tumor. Herein, we present a case in which an elastofibroma protruded into the thoracic cavity, leading to inverted intercostal hernia. Imaging revealed a soft tissue mass containing fat, typical of elastofibroma dorsi; however, precise diagnosis was difficult owing to the location of this mass that protruded into the thoracic cavity. Read More

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Retroperitoneal Liposarcoma: An Unusual Presentation of a Rare Cancer.

J Adv Pract Oncol 2021 Nov 1;12(8):854-862. Epub 2021 Nov 1.

Cancer Treatment Centers of America Phoenix, Goodyear, Arizona.

Retroperitoneal liposarcomas (RLPS) are rare tumors that have variable clinical behavior and complex treatment strategies based on presentation, histopathology, and genomics. Early identification is critical, and complete surgical resection remains the primary treatment, although chemotherapy and radiation are used on individual bases. Presenting symptoms are often nonspecific; therefore, a high degree of suspicion is essential for early diagnosis. Read More

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November 2021

Mesenteric lipoma with small bowel volvulus: A rare cause of upper gastrointestinal obstruction (a case report and literature review).

Int J Surg Case Rep 2022 Mar 25;92:106875. Epub 2022 Feb 25.

Service of Emergency of Visceral Surgery, Ibn Rochd University Hospital Center, Morocco; Department of General Surgery, Ibn Rochd University Hospital Center, Morocco.

Introduction: Small bowel volvulus due to mesenteric lipoma is a rare clinical entity. It poses both a diagnostic and therapeutic challenge. Small bowel mesenteric lipoma is a rare cause of small bowel obstruction. Read More

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Heterogeneous Skin Phantoms for Experimental Validation of Microwave-Based Diagnostic Tools.

Sensors (Basel) 2022 Mar 2;22(5). Epub 2022 Mar 2.

Department of Electrical and Computer Engineering, McGill University, Montreal, QC H3A 0E9, Canada.

Considerable exploration has been done in recent years to exploit the reported inherent dielectric contrast between healthy and malignant tissues for a range of medical applications. In particular, microwave technologies have been investigated towards new diagnostic medical tools. To assess the performance and detection capabilities of such systems, tissue-mimicking phantoms are designed for controlled laboratory experiments. Read More

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Desmoid Tumors Arising on the Mesenteric Surgical Scar of Abdominal Sarcomas.

Cureus 2022 Jan 30;14(1):e21727. Epub 2022 Jan 30.

Surgery, Institut Curie, Paris Sciences et Lettres (PSL) University, Paris, FRA.

A sporadic desmoid tumor (DT) is a rare type of tumor of the mesenchymal connective tissues is now considered an intermediate disease or locally aggressive. They may develop on scars or after traumatism, favored by growth factors released during the initial phase of wound healing. Most of the abdominal DT arising on a scar is described on the wall incision. Read More

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January 2022

Myxoid liposarcoma originating in the retroperitoneum with metastasis to the calcaneus: a rare case report and review of literature.

Skeletal Radiol 2022 Mar 6. Epub 2022 Mar 6.

Department of Orthopaedic Surgery, Kindai University Hospital, 377-2 Ohno-higashi, Osaka-Sayama City, Osaka, 589-8511, Japan.

Myxoid liposarcoma (MLPS) is known to have a variety of metastatic manifestations. We report a MLPS originating in the pelvis with metastasis to the calcaneus. The patient was a 72-year-old man who developed lumbar pain and right lower extremity pain 2 years ago. Read More

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