1,725 results match your criteria Liposarcoma Imaging


An unusual diagnosis of paravertebral lesions: mediastinal myelolipoma.

J Int Med Res 2020 Jul;48(7):300060520936972

Department of Pathology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.

Background: Mediastinal myelolipoma is extremely rare. It is a benign nonfunctioning tumor composed of hematopoietic tissue and mature fatty tissue. Although computed tomography and magnetic resonance imaging are effective in diagnosing mediastinal myelolipoma, a definitive diagnosis is difficult to establish for rare extra-adrenal myelolipomas by imaging alone. Read More

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http://dx.doi.org/10.1177/0300060520936972DOI Listing

Giant paratesticular liposarcoma with lung metastases: a case report and review of the literature.

J Med Case Rep 2020 Jul 2;14(1):86. Epub 2020 Jul 2.

Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Background: Due to its rarity, little is known about the clinical presentations and responses to systemic chemotherapies in advanced and/or metastatic cases of paratesticular liposarcoma.

Case Presentation: Here, we report the case of a 75-year-old Japanese man with giant paratesticular liposarcoma. Imaging studies revealed a 26 cm tumor in his right scrotum and lung metastases at presentation. Read More

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http://dx.doi.org/10.1186/s13256-020-02420-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330966PMC

Excision of a massive lipoma of the thigh following extensive weight loss and bariatric surgery.

BMJ Case Rep 2020 Jun 29;13(6). Epub 2020 Jun 29.

General Surgery, Aberdeen Royal Infirmary, Aberdeen, UK.

A 52-year-old morbidly obese man with a body mass index (BMI) of 78 kg/m lost a great deal of weight through diet control over a 3-year period before undergoing bariatric surgery in the form of laparoscopic sleeve gastrectomy. He continued to lose weight, reducing BMI to 56 kg/m; however, a large left medial thigh mass persisted. Differential diagnoses included lipoma, liposarcoma and hernia. Read More

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http://dx.doi.org/10.1136/bcr-2019-233316DOI Listing

PET/CT Imaging as a Diagnostic Tool in Distinguishing Well-Differentiated versus Dedifferentiated Liposarcoma.

Sarcoma 2020 29;2020:8363986. Epub 2020 May 29.

The University of Texas MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Houston, TX, USA.

Distinguishing well-differentiated liposarcoma (WDLPS) from dedifferentiated liposarcoma (DDLPS) is essential given distinct treatment paradigms and chemosensitivity. Percutaneous biopsy has a low sensitivity for detecting DDLPS. We sought to identify the diagnostic utility of positron emission tomography/computed tomography (PET/CT) in identifying WDLPS versus DDLPS. Read More

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http://dx.doi.org/10.1155/2020/8363986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285404PMC

Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report.

Skeletal Radiol 2020 Jun 21. Epub 2020 Jun 21.

Department of Pathology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, AP-HP.Centre - Université de Paris, 27 rue du Faubourg-Saint-Jacques, 75694, Paris Cedex 14, France.

Parosteal osteosarcomas and well-differentiated liposarcomas are both well-differentiated locally aggressive tumors. They both have simple karyotypes with amplification of the 12q13-15 regions including MDM2 and CDK4 genes. In this report, we describe the case of a parosteal osteosarcoma intertwined with a low-grade component similar to a well-differentiated liposarcoma. Read More

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http://dx.doi.org/10.1007/s00256-020-03509-6DOI Listing

Dedifferentiated liposarcoma of the spermatic cord: Case report and review of literature.

Int J Surg Case Rep 2020 Jun 12;72:418-422. Epub 2020 Jun 12.

Department of Urology, Kendall Regional Medical Center, Miami, FL, USA.

Introduction: Malignant spermatic cord tumors have an annual incidence of 0.3 cases/million. The vast majority of tumors in this region are benign. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306526PMC

Primary cardiac liposarcoma arising from the left atrium in an elderly female; the value of multimodality imaging.

Hellenic J Cardiol 2020 Jun 10. Epub 2020 Jun 10.

Department of Cardiology, "Elpis" General Hospital of Athens, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.hjc.2020.05.005DOI Listing

Usefulness of laparoscopy in the management of incidentally discovered retroperitoneal liposarcoma mimicking inguinal hernia: A case report and literature review.

Int J Surg Case Rep 2020 Jun 3;72:79-84. Epub 2020 Jun 3.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:

Introduction: Liposarcomas comprise around 10%-16% of soft tissue sarcomas. The two major sites of liposarcoma are the extremities and retroperitoneum. However, retroperitoneal liposarcomas mimicking inguinal hernia are rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283968PMC

18F-FDG PET/CT Imaging of Adrenal Liposarcoma.

Clin Nucl Med 2020 Jul;45(7):570-571

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Liposarcoma is a common soft tissue sarcoma in retroperitoneum, but adrenal liposarcoma is rare. We here described a 61-year-old man with left-upper-quadrant pain, hypertension, and weight loss. Abdominal CT showed a large, heterogeneously enhanced mass on the left adrenal area, which compressed the surrounding pancreas, spleen, and left kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003096DOI Listing

Comprehensive Review of Abdominopelvic Mesenchymal Tumors With Radiologic Pathologic Correlation and Update on Current Treatment Guidelines-Part 2.

Semin Ultrasound CT MR 2020 Apr 14;41(2):239-259. Epub 2020 Mar 14.

Department of Radiology and Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR; University of Arkansas for Medical Sciences, Little Rock, AR.

Soft-tissue sarcomas are a diverse group of rare mesenchymal malignancies accounting for only 1% of all solid adult malignancies. These have been categorized in 12 broad groups by the World Health Organization (WHO) with their recent update in 2013. Majority of them lack specific imaging features serving as imaging conundrums for a radiologist. Read More

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http://dx.doi.org/10.1053/j.sult.2020.03.003DOI Listing

Comprehensive Review of Abdominopelvic Mesenchymal Tumors with Radiologic Pathologic Correlation and Update on Current Treatment Guidelines - Part 1.

Semin Ultrasound CT MR 2020 Apr 15;41(2):222-238. Epub 2020 Feb 15.

Department of Radiology and Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR.

Soft-tissue sarcomas are a diverse group of rare mesenchymal malignancies accounting for only 1% of all solid adult malignancies. These have been categorized in 12 broad groups by the World Health Organization (WHO) with their recent update in 2013. Majority of them lack specific imaging features serving as imaging conundrums for a radiologist. Read More

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http://dx.doi.org/10.1053/j.sult.2020.01.002DOI Listing

Pilot study to differentiate lipoma from atypical lipomatous tumour/well-differentiated liposarcoma using MR radiomics-based texture analysis.

Skeletal Radiol 2020 May 18. Epub 2020 May 18.

Clinical Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.

Aims: This pilot study aims to determine if tumour heterogeneity assessed using magnetic resonance imaging (MRI) radiomics-based texture analysis (TA) can differentiate between lipoma and atypical lipomatous tumour (ALT)/well-differentiated liposarcoma (WDL).

Materials And Methods: Thirty consecutive ALT/WDLs and 30 lipomas were included in the study, cases diagnosed both histologically and with murine double minute 2 (MDM2) gene amplification by fluorescence in situ hybridisation (FISH) in excision specimens. Multiple patient, MRI and MRTA factors were assessed. Read More

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http://dx.doi.org/10.1007/s00256-020-03454-4DOI Listing

Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: A case report.

World J Clin Cases 2020 May;8(9):1698-1704

Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.

Background: Esophageal liposarcoma is a rare malignant tumor and an esophageal dedifferentiated liposarcoma (DDL) is extremely rare. There are no reports on the treatment of DDL by thoracoscopic surgery.

Case Summary: A 38-year-old woman presented with dysphagia and dyspnea. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i9.1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211538PMC

Evaluating the Impact of Surveillance Follow-Up Intervals in Patients Following Resection of Primary Well-Differentiated Liposarcoma of the Retroperitoneum.

Ann Surg Oncol 2020 May 14. Epub 2020 May 14.

Department of Surgical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.

Background: Resection of recurrent retroperitoneal well-differentiated liposarcoma (RP-WDLPS) is unlikely to result in cure. Thus, most clinicians delay surgery after recurrence until symptom intolerance or increasing rate of disease progression. The aim of this study was to determine whether longer surveillance intervals in this population would impact outcomes or delay treatment in those who recur. Read More

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http://dx.doi.org/10.1245/s10434-020-08582-8DOI Listing

Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States.

Cancer Med 2020 Jul 6;9(13):4593-4602. Epub 2020 May 6.

Mayo Clinic, Jacksonville, FL, USA.

Background: Outcomes data regarding advanced synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are limited, consisting primarily of retrospective series and post hoc analyses of clinical trials.

Methods: In this multi-center retrospective study, data were abstracted from the medical records of 350 patients from nine sarcoma centers throughout the United States and combined into a registry. Patients with advanced/unresectable or metastatic SS (n = 249) or MRCL (n = 101) who received first-line systemic anticancer therapy and had records of tumor imaging were included. Read More

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http://dx.doi.org/10.1002/cam4.3039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333839PMC

Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging.

Lab Invest 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Myxoid liposarcoma (MLS) is the second most common subtype of liposarcoma, accounting for ~6% of all sarcomas. MLS is characterized by a pathognomonic FUS-DDIT3, or rarely EWSR1-DDIT3, gene fusion. The presence of ≥5% hypercellular round cell areas is associated with a worse prognosis for the patient and is considered high grade. Read More

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http://dx.doi.org/10.1038/s41374-020-0435-2DOI Listing

An MRI-based decision tree to distinguish lipomas and lipoma variants from well-differentiated liposarcoma of the extremity and superficial trunk: Classification and regression tree (CART) analysis.

Eur J Radiol 2020 Jun 18;127:109012. Epub 2020 Apr 18.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: To build and validate a decision tree model using classification and regression tree (CART) analysis to distinguish lipoma and lipoma variants from well-differentiated liposarcoma of the extremities and superficial trunk.

Methods: This retrospective study included patients who underwent surgical resection and preoperative contrast-enhanced MR imaging for lipoma, lipoma variants, and well-differentiated liposarcoma in two tertiary referral centers. Six MRI findings (tumor size, anatomical location, tumor depth, shape, enhancement pattern, and presence of intermingled muscle fibers) and two demographic factors (patient age and sex) were assessed to build a classification tree using CART analysis with minimal error cross-validation pruning based on a complexity parameter. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109012DOI Listing

A Diagnostic Dilemma of a Subcutaneous Hibernoma: Case Report.

Am J Case Rep 2020 Apr 25;21:e921447. Epub 2020 Apr 25.

Department of Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

BACKGROUND Subcutaneous lipomatous lesions are commonly encountered in clinical practice. Hibernoma is a rare subtype of the benign lipomatous tumor, representing 1% of all types. It poses a challenge due to the difficulty of differentiating it from atypical lipomatous lesions and liposarcomas, which may lead to possible inappropriate diagnosis and management. Read More

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http://dx.doi.org/10.12659/AJCR.921447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200092PMC

Intrascrotal hibernoma mimicking liposarcoma: A case study.

Urol Case Rep 2020 Sep 15;32:101206. Epub 2020 Apr 15.

Department of Urology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, Japan.

Hibernoma is a rare benign lipomatous tumor derived from brown fat, which is typically found in infants. Specifically, intrascrotal hibernoma is extremely rare with only one case reported to date. We encountered the second case, which was successfully treated with surgical resection without any recurrence at 3 years. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170945PMC
September 2020

Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials.

Cancer Med 2020 Jun 27;9(11):3656-3667. Epub 2020 Mar 27.

Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.

The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however, little is known about soft tissue sarcoma (STS) regarding this matter. This study aimed to perform a time-lapse analysis of tumor response in patients with STS treated with trabectedin from 2 phase II clinical trials. We examined 66 patients with translocation-related sarcoma registered in 2 Japanese phase II clinical trials. Read More

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http://dx.doi.org/10.1002/cam4.2991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286446PMC

F-FDG PET/CT imaging features of lipomatous tumors.

Am J Nucl Med Mol Imaging 2020 25;10(1):74-82. Epub 2020 Feb 25.

Department of Radiology, Mayo Clinic Rochester, MN 55905, US.

The objective was to evaluate the F-FDG PET/CT characteristics of lipomatous tumors, and examine features helpful in differentiating benign from malignant tumor subtypes. Patients undergoing F-FDG PET/CT from 01/2005 to 03/2018 with subsequent pathologically confirmed liposarcoma, lipoma, or hibernoma were retrospectively reviewed with IRB approval. A variety of imaging features, including metabolic activity and tumor morphology were noted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076300PMC
February 2020

The Role of Tc-99m DTPA Renal Dynamic Scintigraphy in Retroperitoneal Liposarcoma.

Biomed Res Int 2020 22;2020:9765162. Epub 2020 Feb 22.

Department of Nuclear Medicine, First Hospital of China Medical University, Shenyang, Liaoning, China.

Purpose: Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been reported.

Methods: We retrospectively reviewed 7 patients with histopathologically confirmed retroperitoneal liposarcoma who underwent Tc-99m DTPA renal dynamic scintigraphy. The clinical data, histopathological findings, Glomerular Filtration Rate (GFR), and Tc-99m DTPA uptake were recorded. Read More

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http://dx.doi.org/10.1155/2020/9765162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060424PMC
February 2020

Diaphragmatic liposarcoma with gall bladder invasion: CT and MRI findings.

Radiol Case Rep 2020 May 26;15(5):511-514. Epub 2020 Feb 26.

Presbyterian Medical Center, 365 Seo-Won-Ro, Jeonju, South Korea.

Primary liposarcoma originating from the diaphragm is an extremely rare case. Seventy-four-year-old male presented to emergency department with worsening right upper quadrant abdominal pain with dyspnea. Contrast-enhanced computed tomography of the abdomen demonstrated lobulated mass in right hemidiaphragm exhibiting mass effects to adjacent structures compressing gall bladder. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044679PMC

Abdominal metastases of primary extremity soft tissue sarcoma: A systematic review.

World J Clin Oncol 2020 Feb;11(2):74-82

Department of Orthopaedics and Trauma, Medical University of Graz, Graz 8036, Austria.

Background: Despite the fact that about one third of patients with primary localized extremity soft tissue sarcoma (eSTS) will develop metastatic disease, abdominal metastases (AM) and retroperitoneal metastases (RM) constitute rare events. There is no clear consensus on how to achieve follow-up on patients with primary localized eSTS following curative resection, especially regarding the surveillance of potential AM/RM.

Aim: To systematically analyse incidence, diagnosis, treatment and outcome of AM/RM in eSTS patients. Read More

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http://dx.doi.org/10.5306/wjco.v11.i2.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046921PMC
February 2020

Quantitative signal intensity ratios to distinguish between subfascial lipoma and atypical lipomatous tumor/well-differentiated liposarcoma using short-tau inversion recovery (STIR) MRI.

Diagn Interv Imaging 2020 Jun 24;101(6):383-390. Epub 2020 Feb 24.

Department of Radiology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.

Purpose: To establish simple quantitative variables at short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) to identify lipomas with high specificity in patients with indeterminate subfascial lipomatous tumors.

Materials And Methods: The MRI examinations of 26 patients (14 men, 12 women; mean age 63±12.5 [SD] years; range: 40-84years) with histopathologically proven subfascial atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) and those of 68 patients (32 men, 36 women; mean age, 56±13. Read More

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http://dx.doi.org/10.1016/j.diii.2020.01.015DOI Listing

[Imaging of liposarcoma].

Rofo 2020 Feb 27. Epub 2020 Feb 27.

Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Germany.

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http://dx.doi.org/10.1055/a-1108-1961DOI Listing
February 2020

Magnetic resonance imaging assessment of chemotherapy-related adipocytic maturation in myxoid/round cell liposarcomas: specificity and prognostic value.

Br J Radiol 2020 Jun 6;93(1110):20190794. Epub 2020 Mar 6.

Department of Radiology, Institut Bergonie, F-33000, Bordeaux, France.

Objective: To investigate the specificity, clinical implication and prognostic value of MRI adipocytic maturation (MAM) in myxoid/round cells liposarcomas (MRC-LPS) treated with neoadjuvant chemotherapy (NAC).

Methods: Of the 89 patients diagnosed with MRC-LPS at our sarcoma reference center between 2008 and 2018, 28 were included as they were treated with NAC, surgery and radiotherapy. All patients underwent contrast-enhanced MRIs at baseline and late evaluation. Read More

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http://dx.doi.org/10.1259/bjr.20190794DOI Listing

Primary myxoid liposarcoma of the pelvis: An unusual location.

Radiol Case Rep 2020 Apr 15;15(4):431-434. Epub 2020 Feb 15.

Department of Radiology, Hospital de Valme. Ctra de Cádiz s/n, C/ Angel Ganivet N° 12 Sevilla 41013 Spain.

Myxoid liposarcoma is the second most common type of liposarcoma, normally located in deep tissues of the lower extremities and rarely in the mesenchyma of abdomen and pelvis We present a patient who, incidentally, showed a large pelvis mass. CT and MR revealed a loculated lesión with hypodense areas and very high signal in T2 respectively as well as heterogeneous contrast enhancement. The imaging findings of pelvic myxoid liposarcoma are nonspecific, but nevertheless a painless mesenchymal mass should be considered when we see lesions of myxoid aspect in the pelvic area without a clear relationship with defined anatomic structures. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025956PMC

Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single-centre study.

ANZ J Surg 2020 04 16;90(4):497-502. Epub 2020 Feb 16.

Department of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Background: Retroperitoneal sarcomas are rare soft tissue tumours accounting for 10-15% of soft tissue sarcomas. Patient prognosis and treatment recommendations (including extent of surgery and neoadjuvant strategies) are determined by the pre-operative histopathological subtype and grade obtained from biopsy and thus it is important to understand the accuracy of biopsy in retroperitoneal masses.

Methods: This study presents a case series of primary retroperitoneal sarcomas managed at Peter MacCallum Cancer Centre (PMCC) between 2008 and 2019. Read More

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http://dx.doi.org/10.1111/ans.15723DOI Listing

Macroscopic Appearance of Giant Adrenal Myelolipoma During Laparoscopy: An Adjunct in Differential Diagnosis.

Cureus 2020 Jan 7;12(1):e6582. Epub 2020 Jan 7.

Urology, Korgialenio-Benakio Hellenic Red Cross Hospital, Athens, GRC.

Giant adrenal myelolipoma is a rare, benign, sizable, mesenchymal tumor. Preoperative differential diagnosis from retroperitoneal liposarcoma may be challenging. A 66-year-old female patient was admitted because of a sizable tumor at the right retroperitoneal space, incidentally discovered during abdominal ultrasonography for screening purpose. Read More

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http://dx.doi.org/10.7759/cureus.6582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001128PMC
January 2020

Tumor-to-Tumor Metastasis: Prostate Carcinoma Metastatic to Soft Tissue Sarcoma, a Previously Unreported Event.

Int J Surg Pathol 2020 Apr 6;28(2):196-199. Epub 2019 Sep 6.

University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Tumor-to-tumor metastasis is an unusual phenomenon wherein one distinct malignancy is present within the substance of another independent tumor. This event is rare, difficult to detect with imaging, and, due to conflicting terminology in the literature, can be challenging to classify. This article reports the first documented case of tumor-to-tumor metastasis involving prostatic adenocarcinoma and myxoid liposarcoma, reviews the available literature for carcinoma metastatic to sarcoma, and discusses the current situation within the context of the established criteria for the classification of combination tumors. Read More

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http://dx.doi.org/10.1177/1066896919872805DOI Listing
April 2020
0.961 Impact Factor

Oral liposarcoma in elderly: Case report and literature analysis.

Medicine (Baltimore) 2020 Feb;99(6):e18985

Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences.

Rationale: Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign lesion because of its asymptomatic and indolent clinical course. we report a case of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of buccal mucosa, provisionally diagnosed as lipoma.

Patient Concerns: A 97-year-old female was referred to dentistry and oral surgery department with an asymptomatic mass on the right buccal mucosa which had been present for an unknown period of time. Read More

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http://dx.doi.org/10.1097/MD.0000000000018985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015570PMC
February 2020

Paratesticular Mesenchymal Malignancies: A Single-Center Case Series, Clinical Management, and Review of Literature.

Integr Cancer Ther 2020 Jan-Dec;19:1534735419900554

Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Primary soft tissue sarcomas arising from the male urinary and genital tract are rare tumors, only accounting for 1% to 2% of all malignancies of the genitourinary tract. Clinical management of advanced disease is lacking in standardized recommendations due to the rarity of the disease. To date, complete and extensive surgery represents the only curative and standardized approach for localized disease, while the impact of retroperitoneal lymphadenectomy and adjuvant treatments on clinical outcomes are still unclear. Read More

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http://dx.doi.org/10.1177/1534735419900554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050957PMC

State-of-the-art MR Imaging of Fat-containing Focal Lesions of the Liver.

Curr Med Imaging Rev 2019 ;15(5):435-442

Department of Radiology I, Maria Skłodowska-Curie Memorial Cancer Centre, Institute of Oncology, Ul. Roentgena 5, 02-781 Warszawa, Poland.

Background: Fat can be identified in numerous liver lesions, and usually is not a specific finding. Distinguishing between different kinds of fatty deposits is an important part of differential diagnosis. Magnetic Resonance Imaging (MRI) is superior to other imaging techniques because it allows distinguishing intracellular from macroscopic fat. Read More

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http://dx.doi.org/10.2174/1573405614666171218154838DOI Listing
January 2019

Surgical treatment for giant retroperitoneal well-differentiated liposarcoma (WDLPS): case report and literature review.

G Chir 2019 Nov-Dec;40(6):539-543

WDLPS are very rare retroperioneal tumors that can reach huge size before becoming symptomatic. The aim of this article is show the diagnostic management and the surgical approach to giant WDLPS. A standard treatment has yet to be established because the pre-operative diagnosis is very difficult. Read More

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February 2020

Qualitative evaluation of MRI features of lipoma and atypical lipomatous tumor: results from a multicenter study.

Skeletal Radiol 2020 Jun 22;49(6):1005-1014. Epub 2020 Jan 22.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Objectives: The objectives of the study are (1) to distinguish lipoma (L) from atypical lipomatous tumor (ALT) using MRI qualitative features, (2) to assess the value of contrast enhancement, and (3) to evaluate the reproducibility and confidence level of radiological readings.

Materials And Methods: Patients with pathologically proven L or ALT, who underwent MRI within 3 months from surgical excision were included in this retrospective multicenter international study. Two radiologists independently reviewed MRI centrally. Read More

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http://dx.doi.org/10.1007/s00256-020-03372-5DOI Listing

Giant recurrent mixed-type liposarcoma of the retroperitoneum: report of a case and review of literature.

Int J Clin Exp Pathol 2019 1;12(4):1406-1411. Epub 2019 Apr 1.

Department of Pathology, The Affiliated Hospital of Zunyi Medical University Guizhou 563000, China.

Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals, especially tumors of mixed histologic pattern. We present a case of a 63-year-old woman with a history of slowly increasing abdominal volume over 2 years. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947073PMC

[A Case of Dedifferentiated Liposarcoma of the Spermatic Cord].

Hinyokika Kiyo 2019 Dec;65(12):529-532

The Department of Urology, Hamamatsu Rosai Hospital.

A74-year-old man was referred to the department of general surgery in our hospital because of a painless right scrotal swelling persisting for three months. On physical examination, the patient was found to have an inguinal hernia. The patient underwent laparoscopic transabdominal preperitoneal repair, but no inguinal hernia was detected. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_12_529DOI Listing
December 2019

Clear cell renal carcinoma synchronous with dedifferentiated liposarcoma: a case report and review of the literature.

J Med Case Rep 2020 Jan 8;14(1). Epub 2020 Jan 8.

Hematology/Oncology Department, Fundación Valle del Lili, Cali, Carrera 98 No. 18-49, Colombia.

Background: Multiple primary malignant neoplasms are not frequent but are increasing in incidence. Some of them are associated with genetic syndromes such as von Hippel-Lindau syndrome and Li-Fraumeni syndrome. Dedifferentiated liposarcoma is one of the rarest soft tissue tumors, and clear cell renal carcinoma is the most frequent kidney cancer. Read More

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http://dx.doi.org/10.1186/s13256-019-2320-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950918PMC
January 2020

Long-term disease control by trabectedin in a patient with dedifferentiated liposarcoma: A case report.

Medicine (Baltimore) 2020 Jan;99(2):e18689

Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, Japan.

Rationale: Trabectedin is an antitumor drug considered to be effective for liposarcoma, leiomyosarcoma, and translocation-related sarcoma. Concerning liposarcoma subtypes, evidence of the efficacy of trabectedin for dedifferentiated liposarcoma (DDLPS) is poor, whereas it is known to have high efficacy against myxoid liposarcoma. Moreover, there are few reports of long-term trabectedin treatment of cases of DDLPS. Read More

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http://dx.doi.org/10.1097/MD.0000000000018689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959950PMC
January 2020

A malignant phyllodes tumor with liposarcomatous differentiation case with 3-year follow-up.

Rom J Morphol Embryol 2019 ;60(3):979-983

Department of Pathology, "Prof. Dr. Ion Chiricuţă" Oncological Institute, Cluj-Napoca, Romania;

Phyllodes tumors (PTs) are a group of rarely breast tumors of fibro-epithelial origin, counting for about 1% of the breast malignancies divided, based on histological features, in benign, borderline and malignant neoplasms, arising most of them in women in their 40's. Among this complex group of tumors, the liposarcomatous differentiation is an even more rare lesion, counting for about 0.3% of all primary sarcomas of the breast. Read More

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Retroperitoneal Liposarcoma with Multilocular Cysts.

Case Rep Gastroenterol 2019 Sep-Dec;13(3):514-520. Epub 2019 Dec 10.

Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan.

In this study, we describe a 60-year-old man with a giant retroperitoneal liposarcoma with multilocular cysts. He was admitted to our hospital because of a 5-month history of abdominal distention. Abdominal computed tomography revealed a giant lobulated cystic mass occupying the retroperitoneal space that contained partially solid fat components. Read More

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http://dx.doi.org/10.1159/000504695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940463PMC
December 2019

Liposarcoma of the Arygepiglottic Fold: Teaching point: A mosaic tumor pattern mixing fatty and non-fatty enhancing components suggests liposarcoma, even in very rare locations such as neck spaces.

J Belg Soc Radiol 2019 Dec 20;103(1):80. Epub 2019 Dec 20.

Cliniques Universitaires Saint Luc, BE.

Liposarcoma of the larynx and hypopharynx is very rare. Computed tomography (CT) and magnetic resonance imaging (MRI) examinations may synergistically disclose suggestive features of a fat-containing tumor with non-fatty enhancing sub-areas. Diagnosis relies on histological examination of a biopsic specimen. Read More

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http://dx.doi.org/10.5334/jbsr.1868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923775PMC
December 2019

Lipoma of the Larynx and Other Differential Diagnoses.

J Clin Imaging Sci 2019 18;9:51. Epub 2019 Nov 18.

Department of Radiology, Mayo Clinic, Jacksonville, Florida, United States.

Fatty lesions in the head and neck region are uncommon but can present in any subsite, including rarely the larynx. Most commonly, the fatty lesion is a benign lipoma and an incidental finding as in this case. However, the lesion must be differentiated from other fatty lesions such as liposarcoma, lipoblastoma, and hibernoma. Read More

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http://dx.doi.org/10.25259/JCIS_123_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884984PMC
November 2019

Myxoid Liposarcoma With Skeletal Metastases: Pathophysiology and Imaging Characteristics.

Curr Probl Diagn Radiol 2019 Oct 30. Epub 2019 Oct 30.

Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX.

Liposarcoma is a commonly occurring soft tissue sarcoma that can be divided into 4 subtypes. Myxoid and round cell liposarcoma (MRCL) represent one of these subtypes and are classified together due to their shared chromosomal translocation. Histologic analysis of MRCL reveals a myxoid matrix with a delicate capillary network and dispersed lipoblasts. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2019.10.008DOI Listing
October 2019

Retroperitoneal Liposarcoma on 99mTc-DTPA Renal Scintigraphy.

Clin Nucl Med 2020 Feb;45(2):129-130

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

Retroperitoneal liposarcoma is usually large and can press on other organs. We report a case of a 66-year-old woman with a history of retroperitoneal liposarcoma resection who presented to the emergency department with abdominal pain. Ultrasonography revealed a large abdominal mass with renal displacement. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002854DOI Listing
February 2020

Deep-seated Hibernoma of Thigh: A Rare Benign Adipocytic Tumor.

J Coll Physicians Surg Pak 2019 Dec;29(12):S117-S119

Jinnah Burn and Reconstructive Surgery Center, Lahore, Pakistan.

Hibernoma is a rare benign soft tissue adipocytic tumor. Mostly found in adults, it is usually located in the limbs, and is deepseated or intramuscular. Usually asymptomatic, it causes symptoms when it becomes large enough to compress adjacent structures, mimicking well differentiated liposarcoma clinically and radiologically. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.12.S117DOI Listing
December 2019

Lipomatous Soft Tissue Masses: Challenging the Paradigm of Routine Preoperative Biopsy.

J Surg Res 2020 03 23;247:103-107. Epub 2019 Nov 23.

Division of Surgical Oncology, Department of Surgery, Harbor-UCLA Medical Center, Torrance, California. Electronic address:

Background: Lipomatous masses are the most common soft tissue tumors. While the majority are benign lipomas, it is important to identify those masses that are malignant prior to excision. Current guidelines recommend core needle biopsy (CNB) for all lipomatous masses larger than 3-5 cm. Read More

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http://dx.doi.org/10.1016/j.jss.2019.10.037DOI Listing

Radiomics approach to distinguish between well differentiated liposarcomas and lipomas on MRI.

Br J Surg 2019 12;106(13):1800-1809

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.

Background: Well differentiated liposarcoma (WDLPS) can be difficult to distinguish from lipoma. Currently, this distinction is made by testing for MDM2 amplification, which requires a biopsy. The aim of this study was to develop a noninvasive method to predict MDM2 amplification status using radiomics features derived from MRI. Read More

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http://dx.doi.org/10.1002/bjs.11410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899528PMC
December 2019

Incidental dedifferentiated mediastinal liposarcoma on F-18-fluciclovine PET/CT.

Clin Imaging 2020 Jan 13;59(1):21-24. Epub 2019 Sep 13.

Department of Cardiovascular and Thoracic Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, United States.

Fat-containing mediastinal masses, particularly mediastinal liposarcomas, are rare neoplasms that can grow to large sizes before becoming symptomatic and may be incidentally found on radiology examinations. In this case report, a 67-year-old male with a history of prostate cancer status post prostatectomy presented for an F-18-fluciclovine PET/CT for a rising, clinically detectable PSA and indeterminate pelvic lymph nodes seen on multiparametric MRI of the prostate. No local tumor recurrence or metastatic disease from prostate cancer was identified, but the PET/CT demonstrated a mixed soft tissue and fat density prevascular (anterior) mediastinal mass with low-level radiotracer uptake. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.08.004DOI Listing
January 2020