7,548 results match your criteria Liposarcoma

Immune checkpoint inhibitors in treatment of soft-tissue sarcoma: A systematic review and meta-analysis.

Eur J Cancer 2021 Jun 6;152:165-182. Epub 2021 Jun 6.

Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium; Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.

Background: Soft-tissue sarcomas (STSs) are rare malignancies, accounting for approximately 1% of adult cancer. Metastatic disease carries a poor prognosis, and various efforts have been made to improve the prognosis of advanced STS, to date with little success. Immune checkpoint inhibitors (ICPIs) have substantially improved prognosis for many cancer types. Read More

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Challenges in the treatment of a giant retroperitoneal liposarcoma.

Ann Ital Chir 2020 Aug 28;9. Epub 2020 Aug 28.

Background: Retroperitoneal soft-tissue sarcoma is a very rare neoplasm, the most frequent histological subtype is liposarcoma with up to 45% of all cases. Unspecific clinical presentation, late diagnosis and high local recurrence rate represent important problems in clinical practice. We present the case of an adult patient with an unusual large liposarcoma of the retroperitoneum analyzing diagnostic workup, surgical approach and therapeutic strategies. Read More

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Hypercalcemia of Malignancy: Simultaneous Elevation in Parathyroid Hormone-Related Peptide and 1,25 Dihydroxyvitamin D in Sarcoma.

AACE Clin Case Rep 2021 May-Jun;7(3):169-173. Epub 2021 Jan 7.

Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

Objective: Hypercalcemia is a common finding in patients who have an underlying malignancy. Only a few cases of hypercalcemia of malignancy have been linked to more than one mechanism of hypercalcemia. Here, we present a patient with liposarcoma and hypercalcemia of malignancy in the setting of simultaneous elevations in parathyroid hormone-related peptide (PTHrP) and 1,25 dihydroxyvitamin D [1,25(OH)D] levels. Read More

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January 2021

Molecular characterization of pleomorphic liposarcomatous differentiation in malignant phyllodes tumor of the breast: A case report.

Pathol Res Pract 2021 May 24;224:153489. Epub 2021 May 24.

Department of Pathology, The 960th Hospital of PLA, Jinan, 250031, China. Electronic address:

Phyllodes tumors of the breast are rare fibroepithelial tumors, and malignant phyllodes tumors occasionally exhibit heterogeneous differentiation. Here, we report a case of malignant phyllodes tumor with pleomorphic liposarcomatous differentiation, and examined the genomic features of both components using capture-based next-generation sequencing of 425 cancer-related genes. A 56-year-old woman presented with a palpable, asymptomatic nodule in the right breast measuring 4. Read More

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Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification.

Head Neck Pathol 2021 Jun 4. Epub 2021 Jun 4.

Department of Laboratory Medicine and Pathology, Anatomic Pathology Division, Hamad Medical Corporation, Doha, Qatar.

Well-differentiated liposarcoma (WDL) is one of the most common soft tissue sarcomas in adults. It has a predilection for middle-aged males and arises in deep-seated locations such as retroperitoneum, mediastinum, and spermatic cord. Its occurrence in young individuals at the hypopharyngeal region is an exceedingly rare event. Read More

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A liposarcoma arising in a pulmonary hamartoma, coexisting with benign metastasizing leiomyoma.

Ann Thorac Surg 2021 May 31. Epub 2021 May 31.

Department of Cardiothoracic Surgery, Lebanese Geitaoui University Medical Centre, Beirut, Lebanon. Electronic address:

Pulmonary hamartoma is a common benign tumor that rarely degenerates into malignancy. We document a unique case of pulmonary hamartoma with malignant transformation into well differentiated liposarcoma, coexisting in proximity to pulmonary nodules representing benign metastasizing leiomyoma in a sixty-year-old lady. Read More

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Model-Based Assessments of CYP3A-Mediated Drug-Drug Interaction Risk of Milademetan.

Clin Transl Sci 2021 Jun 3. Epub 2021 Jun 3.

Quantitative Clinical Pharmacology, Daiichi Sankyo, Inc, 211 Mt Airy Road, Basking Ridge, NJ, 07920, USA.

Milademetan is a small-molecule inhibitor of murine double minute 2 (MDM2) that is in clinical development for advanced solid tumors and hematological cancers, including liposarcoma and acute myeloid leukemia. Milademetan is a CYP3A and P-glycoprotein substrate and moderate CYP3A inhibitor. The current study aims to understand the drug-drug interaction (DDI) risk of milademetan as a CYP3A substrate during its early clinical development. Read More

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Nipple Hibernoma in a Dog: A Case Report With Literature Review.

Front Vet Sci 2021 12;8:627288. Epub 2021 May 12.

Department of Pathology and Molecular Immunology of the Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.

This report provides a clinical, histological, and immunohistochemical description of an unusual hibernoma (pale cell variant) in the subepidermal area of the nipple of a six-year-old bitch. Furthermore, an extensive literature review of hibernomas in animals was made. Physical examination revealed a nodular lesion in the subepidermal area of the third nipple of the left mammary chain. Read More

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The Orphan Nuclear Receptor Gene NR0B2 Is a Favorite Prognosis Factor Modulated by Multiple Cellular Signal Pathways in Human Liver Cancers.

Front Oncol 2021 14;11:691199. Epub 2021 May 14.

Department of Urology, The University of Kansas Medical Center, Kansas City, KS, United States.

Background: Liver cancer is a leading cause of cancer death worldwide, and novel prognostic factor is needed for early detection and therapeutic responsiveness monitoring. The orphan nuclear receptor NR0B2 was reported to suppress liver cancer development in a mouse model, and its expression levels were reduced in liver cancer tissues and cell lines due to hypermethylation within its promoter region. However, it is not clear if NR0B2 expression is associated with cancer survival or disease progression and how NR0B2 gene expression is regulated at the molecular level. Read More

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Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis.

Eur J Orthop Surg Traumatol 2021 May 29. Epub 2021 May 29.

Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Via GC Pupilli n 1, 40136, Bologna, Italy.

Magnetic Resonance Imaging is a fundamental tool in the evaluation of soft tissue sarcoma. Imaging features are relevant for the assessment of treatment strategies, surgical planning and also for patients' prognosis prediction. Among soft tissue sarcoma and also other malignancies, the size of the mass is usually considered the prognostic key element in diagnostic imaging. Read More

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Phase II study of pazopanib with oral topotecan in patients with metastatic and non-resectable soft tissue and bone sarcomas.

Br J Cancer 2021 May 28. Epub 2021 May 28.

Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Pazopanib is active in refractory soft-tissue sarcoma (STS) and significantly prolongs PFS. Prior studies of combinations of metronomic topotecan with pazopanib have indicated preclinical evidence of response in patients with sarcoma.

Methods: This prospective, single arm, phase II study evaluated the efficacy of the combination of pazopanib with topotecan in patients with metastatic or unresectable non-adipocytic STS. Read More

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Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach.

Adv Anat Pathol 2021 May 27. Epub 2021 May 27.

Department of Pathology, Yeungnam University College of Medicine, Daegu, South Korea Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX.

Mesenchymal tumors of the mediastinum are a heterogenous group of rare tumors with divergent lineages. Mediastinal mesenchymal tumors are diagnostically challenging due to their diversity and morphologic overlap with nonmesenchymal lesions arising in the mediastinum. Accurate histologic diagnosis is critical for appropriate patient management and prognostication. Read More

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Giant retroperitoneal dedifferentiated liposarcoma in an old man.

Asian J Surg 2021 May 25. Epub 2021 May 25.

Department of Gastrointestinal Surgery, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China. Electronic address:

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Hypofractionated radiation therapy and wound healing after massive sarcoma resection: Case report and review of the literature.

Int J Surg Case Rep 2021 May 21;83:106005. Epub 2021 May 21.

Department of Orthopaedic Surgery, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States of America.

Introduction: Large high-grade sarcomas are commonly managed with five weeks of pre-operative radiation with chemotherapy followed by surgical resection. Wound complications occur in about one out of three patients with this regimen. Hypofractionated radiation therapy (HFRT) is a developing pre-operative approach that delivers radiation over a shorter duration of 5-10 treatments. Read More

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Diagnosis and Prognosis of Retroperitoneal Liposarcoma: A Single Asian Center Cohort of 57 Cases.

J Oncol 2021 1;2021:7594027. Epub 2021 Apr 1.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Beijing 100730, China.

Background: Liposarcoma is a soft tissue malignancy, commonly observed in the extremities. However, retroperitoneal liposarcoma is seldom reported and its diagnosis is frequently neglected. This study aims to present the clinical characteristics, diagnosis, and prognosis of five liposarcoma subtypes and report our experience of patient treatment. Read More

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FDG PET/CT Findings of a Primary Paravertebral Liposarcoma.

Clin Nucl Med 2021 May 26. Epub 2021 May 26.

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Abstract: Liposarcoma is a soft tissue tumor that commonly appears in the retroperitoneum and the extremities. Herein, we presented the imaging findings of a 68-year-old man with a paravertebral liposarcoma involving the adjacent vertebral bodies, appendices, and ribs. MRI revealed this mass located in the left side of T9 to T10 vertebral bodies. Read More

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Mol Pharmacol 2021 May 24. Epub 2021 May 24.

Craniofacial Biology, University of Colorado Anschutz Medical Campus, United States

The non-taxane microtubule inhibitor, eribulin, is an approved therapeutic for metastatic breast cancer and liposarcoma. Eribulin was previously tested in unselected lung cancer patients and yielded a modest objective response rate of ~5-12 percent. Because lung cancers represent diverse histologies and driving oncogenic mutations, we postulated that eribulin may exhibit properties of a precision oncology agent with a previously undefined specificity for a molecularly distinct subset of lung cancers. Read More

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Aortic valve replacement and coronary artery bypass grafting through a right thoracotomy for a patient with a left chest wall tumor.

Asian Cardiovasc Thorac Ann 2021 May 22:2184923211019541. Epub 2021 May 22.

Department of Cardiovascular Surgery, Ageo Central General Hospital, Ageo, Japan.

A 68-year-old man was diagnosed with severe aortic stenosis and right coronary artery occlusion on preoperative examination for total extirpation of a giant left breast liposarcoma. Prior to the intervention for the liposarcoma, he underwent successful aortic valve replacement and coronary artery bypass grafting via a right anterolateral thoracotomy to avoid the tumor close to the sternum. On postoperative day 28, the patient underwent a successful wide excision of the left chest wall tumor. Read More

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Peritoneal or mesenteric tumours revealing histiocytosis.

BMJ Open Gastroenterol 2021 May;8(1)

Department of Pathology, Hôpital Ambroise-Pare, Boulogne-Billancourt, Île-de-France, France

Objective: Peritoneal or mesenteric tumours may correspond to several tumour types or tumour-like conditions, some of them being represented by histiocytosis. This rare condition often poses diagnostic difficulties that can lead to important time delay in targeted therapies. Our aim was to describe main features of histiocytoses with mesenteric localisation that can improve the diagnostic process. Read More

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Recurrent transient loss of airway secondary to regurgitated pedunculated hypopharyngeal liposarcoma.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Otorhinolaryngology, Head & Neck Surgery, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, UK.

We describe a rare case of hypopharyngeal liposarcoma with an atypical presentation. The patient presented with a 3-month history of intermittent, transient acute airway obstruction. In between episodes, he was asymptomatic. Read More

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Surgery Treatment Improved the Overall Survival Rate in Locoregional Myxoid Leiomyosarcoma than Other Myxosarcomas in the United States.

Oxid Med Cell Longev 2021 30;2021:9999529. Epub 2021 Apr 30.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an 710061, China.

Myxosarcomas are rare malignant tumors of soft connective tissues, classified into various subtypes, including myxoid liposarcoma, myxoid chondrosarcoma, and myxoid leiomyosarcoma. In this study, we proposed to study the demographic, tumor characteristics, and overall survival rate and compared the treatment modalities between these cancers. Patient data collected based on locoregional metastasis presentation of the abovementioned tumors with a cutoff study of survival duration up to 10 years were obtained from the SEER database during 1975-2016. Read More

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Anti-PD-1 Immunotherapy and Bee Venom for Relapsed and Refractory Liposarcoma: A Case Report.

Front Oncol 2021 29;11:668992. Epub 2021 Apr 29.

Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, China.

Cancer immunotherapies, including immune checkpoint inhibitors, elicit long-term clinical responses but many cancer patients do not respond. Intensive efforts are therefore underway to identify additional immune pathways that may be modulated to enhance the efficacy of existing immunotherapies. Bee venom strongly stimulates the immune system, and is used as a complementary therapy to treat cancer pain in patients with advanced tumors in China. Read More

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Recurrent giant retroperitoneal liposarcoma: Review of literature and a rare case report.

Ann Med Surg (Lond) 2021 May 17;65:102329. Epub 2021 Apr 17.

Department of Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital, New Delhi, 110060, India.

Introduction And Importance: Retroperitoneal liposarcomas (RPLS) are usually grow large with frequent recurrences. Complete surgical excision remains the gold standard treatment for primary and even recurrent tumours. Their prognosis depends on their histological type and grade. Read More

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Liposarcoma of the Parapharyngeal Space: a Rare Entity.

Indian J Surg Oncol 2021 Apr 27;12(Suppl 1):205-209. Epub 2021 Feb 27.

Department of ENT and Head and Neck Surgery, Command Hospital Air Force, Bangalore, India.

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Pathological prognostic factors of retroperitoneal liposarcoma: comprehensive clinicopathological analysis of 124 cases.

Ann Transl Med 2021 Apr;9(7):574

Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Background: Retroperitoneal liposarcoma (RLS) is a type of rare malignant tumor. The aim of the present study was to study the correlations between the clinicopathological characteristics and the prognostic factors of RLSso as to delineate independent pathological indicators affecting prognosis.

Methods: The RLS pathological specimens were collected at Beijing Shijitan Hospital Affiliated to Capital Medical University from 2008 to 2018, and were used to study the histopathological features, including tumor size, histological types, lymphatic metastasis, tumor emboli in the blood and lymph vessels, and nerve invasion; immunohistochemical features, including Ki-67 and P53 proteins; and molecular pathological features, such as MDM2 (murine double minute2) gene amplification. Read More

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A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review.

Onco Targets Ther 2021 6;14:3003-3011. Epub 2021 May 6.

Department of Pathology, Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, 832002, People's Republic of China.

Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left breast. Read More

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Outcome after surgical resection of multiple recurrent retroperitoneal soft tissue sarcoma.

Eur J Surg Oncol 2021 May 4. Epub 2021 May 4.

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

Introduction: Local recurrences (LR) and distant metastases (DM) are common in retroperitoneal soft tissue sarcoma (RPS). Longer time to recurrence and resection of the recurrent lesion have been identified as beneficial prognostic factors for overall survival (OS) upon first tumor relapse. However, prognostic factors concerning OS upon subsequent recurrences are scarcely defined. Read More

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Fine needle aspiration cytology of metastatic myxoid liposarcoma to the thyroid.

Diagn Cytopathol 2021 Jul 12;49(7):899-901. Epub 2021 May 12.

Fine Needle Aspiration Biopsy Clinic, Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Downtown Union Square Medical Center, New York, New York, USA.

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Contemporary analysis of epididymal tumors using a national database.

Cent European J Urol 2021 19;74(1):39-43. Epub 2021 Feb 19.

Division of Urology, Department of Surgery, Saint Louis University, St. Louis, MO, United States.

Introduction: Epididymal tumors are rare malignancies with sparse research available to guide recommendations. We sought to characterize malignant epididymal tumors in the United States using population level data.

Material And Methods: The Surveillance, Epidemiology, and End-Results database was queried for patients diagnosed with malignant epididymal tumors between 1975-2016. Read More

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February 2021

[Rapid Recurrence of Dedifferentiated Liposarcoma of Occult Primary in the Abdomen-A Case Report].

Gan To Kagaku Ryoho 2021 Apr;48(4):605-607

Dept. of Surgery, Minami Nara General Medical Center.

A man in his 70s was referred to our hospital for the examination of an abdominal tumor detected incidentally. The tumor was resected with a preoperative diagnosis of gastric submucosal tumor. As a result of the histopathological examination, dedifferentiated liposarcoma was diagnosed. Read More

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