7,191 results match your criteria Liposarcoma


Primary low grade myxoid liposarcoma of the ovary: A case report and review of literature.

J Obstet Gynaecol Res 2020 Jul 12. Epub 2020 Jul 12.

Department of Pathology, Ankara Numune Training and Research Hospital, Ankara, Turkey.

A 20-year-old female patient presented with the complaint of pelvic pain. Radiological studies showed a cystic mass in the left ovary. Histological examination revealed a myxoid tumor with a chicken wire-like, thin vascularization. Read More

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http://dx.doi.org/10.1111/jog.14395DOI Listing

An unusual diagnosis of paravertebral lesions: mediastinal myelolipoma.

J Int Med Res 2020 Jul;48(7):300060520936972

Department of Pathology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.

Background: Mediastinal myelolipoma is extremely rare. It is a benign nonfunctioning tumor composed of hematopoietic tissue and mature fatty tissue. Although computed tomography and magnetic resonance imaging are effective in diagnosing mediastinal myelolipoma, a definitive diagnosis is difficult to establish for rare extra-adrenal myelolipomas by imaging alone. Read More

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http://dx.doi.org/10.1177/0300060520936972DOI Listing

Early treatment-related neutropenia predicts response to palbociclib.

Br J Cancer 2020 Jul 9. Epub 2020 Jul 9.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Palbociclib is highly active in oestrogen-receptor positive (ER+) metastatic breast cancer, but neutropenia is dose limiting. The goal of this study was to determine whether early neutropenia is associated with disease response to single-agent palbociclib.

Methods: Blood count and disease-response data were analysed from two Phase 2 clinical trials at different institutions using single-agent palbociclib: advanced solid tumours positive for retinoblastoma protein and advanced liposarcoma. Read More

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http://dx.doi.org/10.1038/s41416-020-0967-7DOI Listing

Identification of TYMS as a promoting factor of retroperitoneal liposarcoma progression: Bioinformatics analysis and biological evidence.

Oncol Rep 2020 Aug 5;44(2):565-576. Epub 2020 Jun 5.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato‑Pancreato‑Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China.

Retroperitoneal liposarcoma (RLPS) is one of the most common types of retroperitoneal sarcomas, and has a high recurrence rate. There is an urgent need to further explore its pathogenesis and develop more effective treatment strategies. The aim of the present study was to identify potential driver genes of RLPS through bioinformatics analysis and molecular biology to elucidate potential targets that are suitable for further analysis for the treatment of RLPS. Read More

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http://dx.doi.org/10.3892/or.2020.7635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336505PMC
August 2020
2.191 Impact Factor

An extremely rare case of rapidly growing mediastinal well-differentiated liposarcoma with a sclerosing variant: a case report.

Surg Case Rep 2020 Jul 3;6(1):158. Epub 2020 Jul 3.

Department of Thoracic Surgical Oncology, the Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Liposarcoma arising from the mediastinum is rare, accounting for less than 1% of mediastinal tumors. Furthermore, a rapidly growing well-differentiated liposarcoma is extremely rare. A well-differentiated liposarcoma is usually considered a low-grade malignancy. Read More

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http://dx.doi.org/10.1186/s40792-020-00928-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334334PMC

Intrinsic Laryngeal Lipoma Treated with Transoral CO₂ Laser Microsurgery: An Unusual Case Report.

Am J Case Rep 2020 Jul 3;21:e920528. Epub 2020 Jul 3.

Ear, Nose and Throat (ENT) Unit, Department of General and Specialized Surgery, AOU University of Campania "Luigi Vanvitelli", Napoli, Italy.

BACKGROUND Lipomas, the most common soft tissue tumors, represent almost half of all benign mesenchymal neoplasms and are characterized by the absence of symptoms. However, if they grow in a laryngeal site, they can cause dyspnea and dysphonia which represents one of the major symptoms of benign laryngeal diseases (such as polyps or nodules); these symptoms are often the first symptom of neoplastic diseases. CASE REPORT We present a case of a 28-year-old female patient with a rounded pseudocyst neoformation located in the left aryepiglottic fold that partially hid the homolateral vocal cord and limited its mobility. Read More

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http://dx.doi.org/10.12659/AJCR.920528DOI Listing

Lipoblastoma-like tumor of the spermatic cord: case report and review of the literature.

Virchows Arch 2020 Jul 2. Epub 2020 Jul 2.

Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy.

Lipoblastoma-like tumor is a very rare mesenchymal tumor believed to be restricted to female patients and only recently reported in the spermatic cord of a male patient. We describe herein an additional case of lipoblastoma-like tumor occurring in the spermatic cord, describing its histopathological, immunohistochemical, and molecular features. Read More

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http://dx.doi.org/10.1007/s00428-020-02883-9DOI Listing

Giant paratesticular liposarcoma with lung metastases: a case report and review of the literature.

J Med Case Rep 2020 Jul 2;14(1):86. Epub 2020 Jul 2.

Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Background: Due to its rarity, little is known about the clinical presentations and responses to systemic chemotherapies in advanced and/or metastatic cases of paratesticular liposarcoma.

Case Presentation: Here, we report the case of a 75-year-old Japanese man with giant paratesticular liposarcoma. Imaging studies revealed a 26 cm tumor in his right scrotum and lung metastases at presentation. Read More

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http://dx.doi.org/10.1186/s13256-020-02420-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330966PMC

[Dedifferentiated liposarcoma with epithelioid features: report of a case].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):756-758

Department of Pathology, the People's Hospital of Jiangsu Province (the First Affiliated Hospital of Nanjing Medial University), Nanjing 210029, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20191028-00668DOI Listing

Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis.

In Vivo 2020 Jul-Aug;34(4):1975-1980

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Background/aim: Few studies have examined the prognostic significance of histological subtypes in patients with soft tissue sarcoma (STS) and distant metastasis, and we evaluated the relationship between the histological subtypes and clinical outcomes.

Patients And Methods: This retrospective study evaluated the histological subtypes of 105 patients with STS and distant metastasis. The STS histological subtypes were compared based on the clinical information. Read More

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http://dx.doi.org/10.21873/invivo.11994DOI Listing

Excision of a massive lipoma of the thigh following extensive weight loss and bariatric surgery.

BMJ Case Rep 2020 Jun 29;13(6). Epub 2020 Jun 29.

General Surgery, Aberdeen Royal Infirmary, Aberdeen, UK.

A 52-year-old morbidly obese man with a body mass index (BMI) of 78 kg/m lost a great deal of weight through diet control over a 3-year period before undergoing bariatric surgery in the form of laparoscopic sleeve gastrectomy. He continued to lose weight, reducing BMI to 56 kg/m; however, a large left medial thigh mass persisted. Differential diagnoses included lipoma, liposarcoma and hernia. Read More

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http://dx.doi.org/10.1136/bcr-2019-233316DOI Listing

Proximal Gastrectomy in a Case of Giant Gastric Liposarcoma and a 5-Year Follow-Up.

Case Rep Oncol 2020 May-Aug;13(2):617-620. Epub 2020 Jun 4.

Department of Field Surgery, Faculty of Military Health Science, University of Defence, Hradec Králové, Czechia.

Even though liposarcomas account for 10-20% of all mesenchymal malignancies, they are extremely rarely located in the stomach. We report the case of a female patient with gastric liposarcoma. CT revealed a giant hypoechogenic tumour subcardially on the posterior gastric wall. Read More

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http://dx.doi.org/10.1159/000507477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315206PMC

Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review.

Crit Rev Oncol Hematol 2020 Jun 18;153:103029. Epub 2020 Jun 18.

French Sarcoma Group, Gustave Roussy Cancer Campus, Villejuif, France.

Well-differentiated/dedifferentiated (WD/DD) liposarcomas, the most common form of liposarcomas, constitute up to 20 % of all soft tissue sarcomas. Several oncogenes are thought to be involved in liposarcoma pathogenesis, mainly MDM2, CDK4 and HMGA2. While MDM2 inhibitors are now tested in clinical trials, a second actionable and promising target appears to be cyclin-dependent kinase 4 (CDK4), which is amplified in up to 90 % of well differentiated or dedifferentiated (WD/DD) liposarcoma. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.103029DOI Listing

The β-adrenergic receptor antagonist propranolol offsets resistance mechanisms to chemotherapeutics in diverse sarcoma subtypes: a pilot study.

Sci Rep 2020 Jun 26;10(1):10465. Epub 2020 Jun 26.

Experimental Pharmacology Laboratory, IRCCS Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124, Bari, Italy.

Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we sought to evaluate whether β-adrenergic receptor (β-AR) signalling contributed to the progression of sarcomas and therapy resistance. To assess the translational potential of β-adrenergic receptors, we performed immunohistochemical detection of β1-AR, β2-AR and β3-AR in leiomyosarcoma, liposarcoma and angiosarcoma tissue specimens, reporting the results scored for the intensity. Read More

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http://dx.doi.org/10.1038/s41598-020-67342-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320177PMC

Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model.

Cancer Genomics Proteomics 2020 Jul-Aug;17(4):351-358

AntiCancer, Inc., San Diego, CA, U.S.A.

Background/aim: Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precision oncology. Read More

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http://dx.doi.org/10.21873/cgp.20194DOI Listing

Hydromethanolic Extracts from L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome.

Molecules 2020 Jun 21;25(12). Epub 2020 Jun 21.

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.

Metabolic syndrome includes a cluster of risk factors for many pathological conditions, including hyperglycemia, abdominal obesity, hyperlipidemia, and hypertension. L. (also known as baobab) is used in traditional African Medicine and recent studies showed that it improves the metabolism of carbohydrates and lipids. Read More

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http://dx.doi.org/10.3390/molecules25122858DOI Listing

A Myxoid Liposarcoma Metastasizing to the Parotid Gland.

J Craniofac Surg 2020 Jun 18. Epub 2020 Jun 18.

Pathology Department, IRCCS Regina Elena National Cancer Institute, Rome.

Localization of metastases into the parotid gland is a very uncommon event. Usually they arise from primary tumors located in the head and neck, mainly melanoma or epidermoid carcinoma of the skin, while other histotypes, from others anatomical districts, hardly have a metastatic spread to the parotid. Myxoid Liposarcoma (MLS) is a rare malignant tumor of the soft tissue that mainly occurs in the extremities, representing the second most common subtype of liposarcoma. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006613DOI Listing

The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour.

Anal Cell Pathol (Amst) 2020 28;2020:8232803. Epub 2020 May 28.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1155/2020/8232803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275214PMC

PET/CT Imaging as a Diagnostic Tool in Distinguishing Well-Differentiated versus Dedifferentiated Liposarcoma.

Sarcoma 2020 29;2020:8363986. Epub 2020 May 29.

The University of Texas MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Houston, TX, USA.

Distinguishing well-differentiated liposarcoma (WDLPS) from dedifferentiated liposarcoma (DDLPS) is essential given distinct treatment paradigms and chemosensitivity. Percutaneous biopsy has a low sensitivity for detecting DDLPS. We sought to identify the diagnostic utility of positron emission tomography/computed tomography (PET/CT) in identifying WDLPS versus DDLPS. Read More

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http://dx.doi.org/10.1155/2020/8363986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285404PMC

A rare cause of pneumoperitoneum due to clostridium perfringens in a cirrhotic patient.

Acta Chir Belg 2020 Jul 1:1-3. Epub 2020 Jul 1.

Department of General, Visceral and Transplantation Surgery, University Hospital, Tübingen, Germany.

Abdominal gas gangrene caused by Clostridium perfringens is a rare differential diagnosis to pneumoperitoneum caused by bowel perforation. There are only a handful of case reports on this topic. We present the case of a 58 year old cirrhotic patient who represented to our ER after complicated surgery for retroperitoneal liposarcoma. Read More

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http://dx.doi.org/10.1080/00015458.2020.1785218DOI Listing

Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report.

Skeletal Radiol 2020 Jun 21. Epub 2020 Jun 21.

Department of Pathology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, AP-HP.Centre - Université de Paris, 27 rue du Faubourg-Saint-Jacques, 75694, Paris Cedex 14, France.

Parosteal osteosarcomas and well-differentiated liposarcomas are both well-differentiated locally aggressive tumors. They both have simple karyotypes with amplification of the 12q13-15 regions including MDM2 and CDK4 genes. In this report, we describe the case of a parosteal osteosarcoma intertwined with a low-grade component similar to a well-differentiated liposarcoma. Read More

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http://dx.doi.org/10.1007/s00256-020-03509-6DOI Listing

Dedifferentiated liposarcoma of the spermatic cord: Case report and review of literature.

Int J Surg Case Rep 2020 Jun 12;72:418-422. Epub 2020 Jun 12.

Department of Urology, Kendall Regional Medical Center, Miami, FL, USA.

Introduction: Malignant spermatic cord tumors have an annual incidence of 0.3 cases/million. The vast majority of tumors in this region are benign. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306526PMC

MDM2 amplification and fusion gene ss18-ssx in a poorly differentiated synovial sarcoma: A rare but puzzling conjunction.

Neoplasia 2020 Aug 16;22(8):311-321. Epub 2020 Jun 16.

Laboratory of Solid Tumor Genetics, University Hospital of Nice-Côte d'Azur University, Nice, France; Laboratory of Solid Tumor Genetics, Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284/INSERM U1081, Nice, France. Electronic address:

The detection of specific alterations by genetic analyses has been included in the diagnostic criterions of the World Health Organization's classification of soft tissues tumors since 2013. The presence of a SS18 rearrangement is pathognomonic of synovial sarcoma (SS). MDM2 amplification is strongly correlated to well-differentiated or dedifferentiated liposarcoma (DDLPS) in the context of sarcoma. Read More

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http://dx.doi.org/10.1016/j.neo.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303914PMC

Periplocin mediates TRAIL-induced apoptosis and cell cycle arrest in human myxofibrosarcoma cells via the ERK/p38/JNK pathway.

Phytomedicine 2020 Jun 5;76:153262. Epub 2020 Jun 5.

Division of Biomedical Research, Medical University Graz, Roseggerweg 48, 8036Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010Graz, Austria.

Background: Periploca sepium is traditionally used in Chinese medicine to treat particularly rheumatic disorders and as a tonic. Periplocin was found as the most cytotoxic compound of its root bark and induced death receptor mediated apoptosis in liposarcoma cells. Sarcomas are a rare type of cancer with only a few treatment options. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153262DOI Listing

Well-differentiated liposarcoma disguised as a recurrent lipoma of the forearm flexor compartment: A case report.

Int J Surg Case Rep 2020 May 30;72:91-95. Epub 2020 May 30.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia. Electronic address:

Introduction: Lipomas are common benign mesenchymal tumor that arise from the adipose tissue. Differential diagnosis between the benign and malignant form (liposarcoma) must be made to prevent complication and recurrence.

Presentation Of Case: We reported a 63-year-old man who presented with recurrent large-sized mass on the right forearm with the first presentation approximately 28 years before being treated in our center. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289738PMC

Primary cardiac liposarcoma arising from the left atrium in an elderly female patient; the value of multimodality imaging.

Hellenic J Cardiol 2020 Jun 10. Epub 2020 Jun 10.

Department of Cardiology, "Elpis" General Hospital of Athens, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.hjc.2020.05.005DOI Listing

A Reappraisal of Superficial Pleomorphic Liposarcoma.

Am J Clin Pathol 2020 Jun 11. Epub 2020 Jun 11.

Department of Pathology, Virginia Commonwealth University Health System, Richmond.

Objectives: Superficial pleomorphic liposarcoma (PL) has a favorable prognosis compared to deeply seated PL. Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases.

Methods: Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polymorphism (SNP) microarray studies were performed for cases previously designated superficial PL. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa045DOI Listing

Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma.

Sci Transl Med 2020 Jun;12(547)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier F-34298, France.

Well-differentiated and dedifferentiated liposarcomas (LPSs) are characterized by a systematic amplification of the oncogene, which encodes a key negative regulator of the p53 pathway. The molecular mechanisms underlying MDM2 overexpression while sparing wild-type p53 in LPS remain poorly understood. Here, we show that the p53-independent metabolic functions of chromatin-bound MDM2 are exacerbated in LPS and mediate an addiction to serine metabolism that sustains nucleotide synthesis and tumor growth. Read More

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http://dx.doi.org/10.1126/scitranslmed.aay2163DOI Listing
June 2020
15.843 Impact Factor

Ileocecal intussusception caused by two different tumors - which is the culprit lesion? A case report.

World J Clin Cases 2020 May;8(10):2044-2049

Department of Pancreatic-Biliary Surgery, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

Background: Ileocecal intussusception caused by two different tumors is rare, according to a literature review. We describe a case of a male patient with a cauliflower-like mass in the middle of the transverse colon observed by colonoscopy before surgery. It was considered to be intussusception caused by colon cancer. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i10.2044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262695PMC

Usefulness of laparoscopy in the management of incidentally discovered retroperitoneal liposarcoma mimicking inguinal hernia: A case report and literature review.

Int J Surg Case Rep 2020 Jun 3;72:79-84. Epub 2020 Jun 3.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:

Introduction: Liposarcomas comprise around 10%-16% of soft tissue sarcomas. The two major sites of liposarcoma are the extremities and retroperitoneum. However, retroperitoneal liposarcomas mimicking inguinal hernia are rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283968PMC

Survival and risk factors in patients with liposarcoma with distant metastasis.

Am J Transl Res 2020 15;12(5):2071-2082. Epub 2020 May 15.

Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer Tianjin, China.

Background: The distant metastasis in liposarcoma is not thoroughly investigated. Based on a large cohort, we attempted to evaluate the survival in liposarcoma patients with distant metastasis and to reveal the risk factors.

Methods: The records of liposarcoma patients with or without distant metastasis were extracted from the Surveillance, Epidemiology, and End Result (SEER) database from 2010 to 2016. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269996PMC
May 2020
3.226 Impact Factor

Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma.

J Int Med Res 2020 Jun;48(6):300060520926355

Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China.

Objectives: A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with liposarcoma by examining associations between their expression levels and clinical outcomes.

Methods: Clinical and histopathological characteristics and follow-up and survival information were retrospectively reviewed for 42 liposarcoma cases. Read More

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http://dx.doi.org/10.1177/0300060520926355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273778PMC

Hemophilic Pseudotumors: Diagnosis and Management.

Arch Bone Jt Surg 2020 Mar;8(2):121-130

Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Paseo de la Castellana, Madrid, Spain.

Prevention is essential for avoiding the complications of muscle hematomas (pseudotumors, compartment syndromes and peripheral nerve lesions) in hemophilic patients. This is achieved through early diagnosis of muscle hematomas and proper long-term hematological treatment until they have resolved (confirmed by image studies). Ultrasound-guided percutaneous drainage could be beneficial in terms of achieving better and faster symptom relief. Read More

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http://dx.doi.org/10.22038/abjs.2019.40547.2090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191985PMC

Securing the Sails.

JAMA 2020 06;323(21):2143-2144

University of Colorado School of Medicine Department of Pediatrics, Aurora.

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http://dx.doi.org/10.1001/jama.2020.7164DOI Listing

En bloc resection of giant retroperitoneal liposarcoma involving the right colon - a video vignette.

Colorectal Dis 2020 May 30. Epub 2020 May 30.

Emergency Surgery Unit, St Orsola Hospital, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/codi.15163DOI Listing

Extracellular vesicle cross-talk in the liposarcoma microenvironment.

Cancer Lett 2020 Sep 26;487:27-33. Epub 2020 May 26.

The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Liposarcoma (LPS) is the most prevalent soft tissue sarcoma; among the four different LPS subtypes, dedifferentiated liposarcoma (DDLPS) is especially worrisome given its propensity for local and distant recurrence, with an overall survival rate of only 10% at 10 years. Our understanding of the molecular drivers of this disease is rudimentary at best; knowledge about how DDLPS interacts with cells in the tumor microenvironment (TME) is also lacking. Extracellular vesicle (EVs) have been studied in a number of different systems concerning their ability to influence the TME transferring bioactive molecules. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.04.026DOI Listing
September 2020

A Hypothesis of Circulating MicroRNAs' Implication in High Incidence of Atrial Fibrillation and Other Electrocardiographic Abnormalities in Cancer Patients.

Adv Exp Med Biol 2020 ;1196:1-9

Department of Informatics, Ionian University, Corfu, Greece.

MicroRNAs are short non-coding RNA molecules that control posttranscriptional gene expression and are present in tissues cells but also circulate in biological fluids in various forms (exosome, connected with proteins, apoptotic bodies, etc.). The roles that circulated extracellular serum microRNAs possess in cancer development, like in the delivery from a recipient cell to distant tissues and the repression of host genes resulting in the impairment of critical functions, are still undetermined. Read More

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http://dx.doi.org/10.1007/978-3-030-32637-1_1DOI Listing
January 2020

18F-FDG PET/CT Imaging of Adrenal Liposarcoma.

Clin Nucl Med 2020 Jul;45(7):570-571

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Liposarcoma is a common soft tissue sarcoma in retroperitoneum, but adrenal liposarcoma is rare. We here described a 61-year-old man with left-upper-quadrant pain, hypertension, and weight loss. Abdominal CT showed a large, heterogeneously enhanced mass on the left adrenal area, which compressed the surrounding pancreas, spleen, and left kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003096DOI Listing

Impact of centralization in primary retroperitoneal sarcoma treatment: analysis using hospital-based cancer registry data in Japan.

Int J Clin Oncol 2020 May 25. Epub 2020 May 25.

Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: To elucidate the clinicopathological features, hospital-based care volume and prognoses associated with primary retroperitoneal sarcoma (PRS).

Methods: Clinical data on PRS cases, diagnosed from 2008 to 2009 (cohort A) and from 2012 to 2015 (cohort B), were obtained from the national hospital-based cancer registry in Japan. Since data on survival, 5 years after PRS diagnosis, were available only for cohort A, patient prognoses were analyzed in this group alone. Read More

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http://dx.doi.org/10.1007/s10147-020-01709-7DOI Listing

Primary Well-Differentiated Liposarcoma of the Orbit.

Int J Surg Pathol 2020 May 25:1066896920925168. Epub 2020 May 25.

Queen Elizabeth Hospital, Hong Kong China SAR.

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http://dx.doi.org/10.1177/1066896920925168DOI Listing

A case of retroperitoneal dedifferentiated liposarcoma successfully treated by neoadjuvant chemotherapy and subsequent surgery.

Surg Case Rep 2020 May 24;6(1):105. Epub 2020 May 24.

Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Retroperitoneal liposarcoma (RPLS) is the most commonly observed soft tissue sarcoma in the retroperitoneal space. Although the beneficial effect of chemotherapy for RPLS is controversial, there are some reports that have shown a considerable tumor-suppressive effect of chemotherapy in RPLS. We demonstrate a case of dedifferentiated RPLS, which was initially considered inoperable but was successfully treated by neoadjuvant chemotherapy and subsequent curative resection. Read More

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http://dx.doi.org/10.1186/s40792-020-00865-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246274PMC

Comprehensive Review of Abdominopelvic Mesenchymal Tumors With Radiologic Pathologic Correlation and Update on Current Treatment Guidelines-Part 2.

Semin Ultrasound CT MR 2020 Apr 14;41(2):239-259. Epub 2020 Mar 14.

Department of Radiology and Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR; University of Arkansas for Medical Sciences, Little Rock, AR.

Soft-tissue sarcomas are a diverse group of rare mesenchymal malignancies accounting for only 1% of all solid adult malignancies. These have been categorized in 12 broad groups by the World Health Organization (WHO) with their recent update in 2013. Majority of them lack specific imaging features serving as imaging conundrums for a radiologist. Read More

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http://dx.doi.org/10.1053/j.sult.2020.03.003DOI Listing

Comprehensive Review of Abdominopelvic Mesenchymal Tumors with Radiologic Pathologic Correlation and Update on Current Treatment Guidelines - Part 1.

Semin Ultrasound CT MR 2020 Apr 15;41(2):222-238. Epub 2020 Feb 15.

Department of Radiology and Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR.

Soft-tissue sarcomas are a diverse group of rare mesenchymal malignancies accounting for only 1% of all solid adult malignancies. These have been categorized in 12 broad groups by the World Health Organization (WHO) with their recent update in 2013. Majority of them lack specific imaging features serving as imaging conundrums for a radiologist. Read More

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http://dx.doi.org/10.1053/j.sult.2020.01.002DOI Listing

Dysplastic lipoma: potential diagnostic pitfall of using MDM2 RNA in situ hybridization to distinguish between lipoma and atypical lipomatous tumor.

Hum Pathol 2020 Jul 18;101:53-57. Epub 2020 May 18.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States. Electronic address:

The distinction between lipoma and atypical lipomatous tumor can be challenging in some cases. While detection of MDM2 gene amplification via fluorescence in situ hybridization (FISH) has been well established as a diagnostic tool to distinguish atypical lipomatous tumor and well-differentiated liposarcoma from benign mimics, MDM2 RNA in situ hybridization (RNA-ISH) has recently been proposed as an alternative diagnostic assay. During clinical workup for lipomatous tumors using MDM2 RNA-ISH, we noticed several dysplastic lipomas that were positive for MDM2 RNA-ISH but negative for MDM2 amplification by FISH. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.05.004DOI Listing

Primary pleural liposarcoma combined spindle cell lipoma of the lung.

Thorac Cancer 2020 Jul 21;11(7):2059-2062. Epub 2020 May 21.

Department of Internal Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea.

Liposarcoma is a malignant adipose tissue tumor which mainly originates from the extremities and retroperitoneum. Primary pleural liposarcoma is very rare. Spindle cell lipoma is a rare benign adipose tissue tumor. Read More

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http://dx.doi.org/10.1111/1759-7714.13495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327671PMC

Pilot study to differentiate lipoma from atypical lipomatous tumour/well-differentiated liposarcoma using MR radiomics-based texture analysis.

Skeletal Radiol 2020 May 18. Epub 2020 May 18.

Clinical Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.

Aims: This pilot study aims to determine if tumour heterogeneity assessed using magnetic resonance imaging (MRI) radiomics-based texture analysis (TA) can differentiate between lipoma and atypical lipomatous tumour (ALT)/well-differentiated liposarcoma (WDL).

Materials And Methods: Thirty consecutive ALT/WDLs and 30 lipomas were included in the study, cases diagnosed both histologically and with murine double minute 2 (MDM2) gene amplification by fluorescence in situ hybridisation (FISH) in excision specimens. Multiple patient, MRI and MRTA factors were assessed. Read More

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http://dx.doi.org/10.1007/s00256-020-03454-4DOI Listing

Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups.

J Clin Oncol 2020 Jul 18;38(19):2178-2186. Epub 2020 May 18.

Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose: To determine whether the administration of histology-tailored neoadjuvant chemotherapy (HT) was superior to the administration of standard anthracycline plus ifosfamide neoadjuvant chemotherapy (A+I) in high-risk soft tissue sarcoma (STS) of an extremity or the trunk wall.

Patients And Methods: This was a randomized, open-label, phase III trial. Patients had localized high-risk STS (grade 3; size, ≥ 5 cm) of an extremity or trunk wall, belonging to one of the following five histologic subtypes: high-grade myxoid liposarcoma (HG-MLPS); leiomyosarcoma (LMS), synovial sarcoma (SS), malignant peripheral nerve sheath tumor (MPNST), and undifferentiated pleomorphic sarcoma (UPS). Read More

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http://dx.doi.org/10.1200/JCO.19.03289DOI Listing

Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: A case report.

World J Clin Cases 2020 May;8(9):1698-1704

Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.

Background: Esophageal liposarcoma is a rare malignant tumor and an esophageal dedifferentiated liposarcoma (DDL) is extremely rare. There are no reports on the treatment of DDL by thoracoscopic surgery.

Case Summary: A 38-year-old woman presented with dysphagia and dyspnea. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i9.1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211538PMC

Dedifferentiated Liposarcoma With Meningothelial-Like Whorls: Five Additional Cases and Review of the Literature.

Int J Surg Pathol 2020 May 17:1066896920921950. Epub 2020 May 17.

Aga Khan University Hospital, Karachi, Pakistan.

. Diagnosis of dedifferentiated liposarcoma (DDL) can sometimes be challenging due to a wide variety of histological features. "Meningothelial-like" whorl is an uncommon histological feature of DDL, which is also observed in neural tumors and follicular dendritic cell sarcoma. Read More

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http://dx.doi.org/10.1177/1066896920921950DOI Listing