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    Fine needle aspiration cytology findings of myxoinflammatory fibroblastic sarcoma: A case report.
    Diagn Cytopathol 2017 May 24. Epub 2017 May 24.
    Department of Molecular and Cellular Pathology, Kanazawa University, Kanazawa, Japan.
    Myxoinflammatory fibroblastic sarcoma (MIFS) is rare low-grade soft-tissue tumor that occurs in extremities. Clinically it is difficult to differentiate from benign lesions, such as nodular fasciitis, and malignant tumors, such as liposarcoma. We report a case of MIFS in the forearm of a 34-year-old man. Read More

    Metastasis of soft tissue sarcomas in lymph node. A cytomorphological study.
    Diagn Cytopathol 2017 May 24. Epub 2017 May 24.
    Department of Pathology, Gujarat Cancer And Research Institute (GCRI), Ahmedabad, Gujarat, India.
    Background: Soft-tissue sarcoma (STS) rarely metastasizes to lymph node compared to carcinoma. Fine-needle aspiration cytology (FNAC) carries a pivotal role in diagnosis of metastatic tumor to lymph node. This study highlights the role of FNAC in diagnosis of STS metastasis to lymph node. Read More

    Elevated NDC80 expression is associated with poor prognosis in osteosarcoma patients.
    Eur Rev Med Pharmacol Sci 2017 May;21(9):2045-2053
    Department of Orthopedics, Shandong Energy Zaozhuang Mining Group Center Hospital, Shandong, China.
    Objective: Osteosarcoma (OS) is a commonly diagnosed bone malignancy in children and adolescents. Nuclear division cycle 80 (NDC80) is a crucial regulator of the cell division cycle that has recently been identified as a novel oncoprotein in various solid tumors; however, its role in OS remains poorly understood. The aim of this study was to investigate correlations between NDC80 expression in OS patients and clinicopathological features and prognosis. Read More

    A clinical review of 11 cases of large-sized well-differentiated liposarcomas.
    Eur J Orthop Surg Traumatol 2017 May 23. Epub 2017 May 23.
    Hospital Clínico San Carlos, Calle Profesor Martín Lagos s/n, 28040, Madrid, Spain.
    Well-differentiated liposarcomas of the extremities are one of the most frequent types of malignant soft tissue tumors in adults. These tumors are typically locally aggressive and show a tendency to recurrence after surgical excision even though they do not metastasize and very rarely dedifferentiate. Its clinical presentation is generally a progressively growing mass causing aesthetic, functional, or compressive symptoms depending on the tumor's size and localization. Read More

    Trabectedin and Eribulin: Where Do They Fit in the Management of Soft Tissue Sarcoma?
    Curr Treat Options Oncol 2017 Jun;18(6):34
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 450, Houston, TX, 77030, USA.
    Opinion Statement: Trabectedin and eribulin are two agents that have been recently approved for the treatment of specific soft tissue sarcoma subtypes. They have proved to be a much-needed line of additional treatment for patients with these rare tumors, but their activity remains admittedly modest in most cases. Further exploitation of these novel agents is likely to require a more granular understanding of the salient mechanisms of action. Read More

    [Subcutaneous myxoid liposarcoma].
    Pan Afr Med J 2017 21;26:162. Epub 2017 Mar 21.
    Centre Mohamed VI du Traitement du Cancer, Casablanca, Maroc.
    Although myxoid liposarcomas (MLS) are the most common type of soft-tissue sarcomas in adults, their primary location in the superficial tissues is rare. So sarcomas are classified as superficial and deep-seated. They are distinct based on their location and their frequency as well as their prognosis which is relatively better in superficial sarcomas. Read More

    [Relapsed Pleomorphic Liposarcoma with Mediastinal Metastasis: A Case Report 
and Review of the Literature].
    Zhongguo Fei Ai Za Zhi 2017 May;20(5):361-365
    Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
    Metastatic pleomorphic liposarcoma in the mediastinum is rare, and the current treatments are most of the times ineffective. We hereby report a case with relapsed pleomorphic liposarcoma adjacent to the psoas major muscle and with mediastinal metastasis, to discuss the clinical features and treatment strategies of pleomorphic liposarcoma. The patient's clinical history, imaging findings, pathological diagnosis, and multidisciplinary treatments were retrospectively analyzed. Read More

    Pleomorphic liposarcoma of the head and neck: Presentation of two cases and literature review.
    Am J Otolaryngol 2017 Apr 22. Epub 2017 Apr 22.
    Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:
    Background: Pleomorphic liposarcoma (PL) is an exceedingly rare tumor of the head and neck. This aggressive liposarcoma variant portends a poorer prognosis compared to more typical sarcomatous tumors.

    Methods: Multi-institutional study including two cases of PL, the first case occurring in the post-auricular region and the second in the cheek with later recurrence within the parotid bed. Read More

    Efficacy of Trabectedin in Patients With Advanced Translocation-Related Sarcomas: Pooled Analysis of Two Phase II Studies.
    Oncologist 2017 May 18. Epub 2017 May 18.
    Department of Musculoskeletal Oncology, Rare Cancer Center, National Cancer Center Hospital, Tokyo, Japan.
    Background: Trabectedin is reported as effective, especially against translocation-related sarcomas (TRSs) after failure of or intolerance to standard chemotherapy. We conducted two phase II studies of TRS, confirming high efficacy of 1.2 mg/m(2) trabectedin. Read More

    Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial.
    Lancet Oncol 2017 May 9. Epub 2017 May 9.
    Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
    Background: Previous trials from our group suggested an overall survival benefit with five cycles of adjuvant full-dose epirubicin plus ifosfamide in localised high-risk soft-tissue sarcoma of the extremities or trunk wall, and no difference in overall survival benefit between three cycles versus five cycles of the same neoadjuvant regimen. We aimed to show the superiority of the neoadjuvant administration of histotype-tailored regimen to standard chemotherapy.

    Methods: For this international, open-label, randomised, controlled, phase 3, multicentre trial, patients were enrolled from 32 hospitals in Italy, Spain, France, and Poland. Read More

    Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models.
    Neoplasia 2017 May 8;19(6):460-470. Epub 2017 May 8.
    Hospital Universitario Central de Asturias - Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Asturias; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain; CIBER en oncología (CIBERONC), Madrid, Spain. Electronic address:
    Trabectedin has been approved for second-line treatment of soft tissue sarcomas. However, its efficacy to target sarcoma initiating cells has not been addressed yet. Here, we used pioneer models of myxoid/round cell liposarcoma (MRCLS) and undifferentiated pleomorphic sarcoma (UPS) developed from transformed human mesenchymal stromal/stem cells (MSCs) to evaluate the effect of trabectedin in the cell type responsible for initiating sarcomagenesis and their derived cancer stem cells (CSC) subpopulations. Read More

    Establishing a patient-derived xenograft model of human myxoid and round-cell liposarcoma.
    Oncotarget 2017 Apr 21. Epub 2017 Apr 21.
    Departments of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
    Myxoid and round cell liposarcoma (MRCL) is a common type of soft tissue sarcoma. The lack of patient-derived tumor xenograft models that are highly consistent with human tumors has limited the drug experiments for this disease. Hence, we aimed to develop and validate a patient-derived tumor xenograft model of MRCL. Read More

    Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
    Radiographics 2017 May-Jun;37(3):797-812
    From the Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (A.D.L., M.A.M.); the American Institute for Radiologic Pathology, Silver Spring, Md (M.A.M.); and the Center of Cancer Research, National Cancer Institute, Bethesda, Md (M.M.M.).
    Soft-tissue sarcomas occurring in the abdomen and pelvis are an uncommon but important group of malignancies. Recent changes to the World Health Organization classification of soft-tissue tumors include the movement of gastrointestinal stromal tumors (GISTs) into the soft-tissue tumor classification. GIST is the most common intraperitoneal sarcoma. Read More

    Soft tissue sarcoma nomograms and their incorporation into practice.
    Cancer 2017 May 10. Epub 2017 May 10.
    Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
    The accurate prediction of prognosis in patients with soft tissue sarcoma (STS) is a challenging issue. Extreme variability in the clinical and pathological characteristics of this family of tumors hinders the simple stratification of patients into meaningful prognostic cohorts. Precision medicine tools for the prediction of prognosis, such as nomograms, enable personalized computation of outcome based on clinical and pathological characteristics of both patient and tumor. Read More

    Incidentally discovered well-differentiated retroperitoneal liposarcoma with inguinal canal herniation: report of 2 cases.
    Radiol Case Rep 2017 Jun 8;12(2):308-312. Epub 2017 Apr 8.
    Department of Radiology, Tor Vergata Polyclinic, Viale Oxford 81, 00100 Rome, Italy.
    Well-differentiated retroperitoneal liposarcomas are slow growing and low-grade tumors, reaching usually huge size before being symptomatic and so diagnosed, therefore with increase of the surgical risk and of the probability of dedifferentiation. Inguinal location of these tumors is unusual and rarely diagnosed. Read More

    HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition.
    Virchows Arch 2017 May 6. Epub 2017 May 6.
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka-ken, 812-8582, Japan.
    Ischemic fasciitis is a benign myofibroblastic lesion, occurring in the sacral region or proximal thigh of elderly or bedridden individuals. The pathogenesis of ischemic fasciitis is thought to be based on ischemic condition; however, it has never been demonstrated. In this study, we examined the expression of ischemia-associated proteins in ischemic fasciitis by immunohistochemical and genetic methods. Read More

    A solitary fibrous tumour mimicking an aggressive angiomyxoma/liposarcoma.
    BMJ Case Rep 2017 May 5;2017. Epub 2017 May 5.
    Division of Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
    We present a case of a solitary fibrous tumour (SFT) resembling an aggressive angiomyxoma/liposarcoma on radiological imaging, causing significant diagnostic challenges preoperatively. A 76-year-old male was incidentally found to have a large pelvic mass on a CT scan. Further evaluation with an MRI scan confirmed a presacral mass containing fat and soft tissue components. Read More

    Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors.
    Pathol Res Pract 2016 Dec 5. Epub 2016 Dec 5.
    Departments of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, 811-8582, Japan. Electronic address:
    Myxofibrosarcoma (MFS) is characterized by abundant myxoid stroma, a wide spectrum of cytological atypia, and frequent local recurrence. Some soft tissue tumors with myxoid stroma can histologically mimic MFS, but have different biological behaviors. Here we sought to identify a useful diagnostic marker for MFS. Read More

    Imaging review of lipomatous musculoskeletal lesions.
    SICOT J 2017 5;3:34. Epub 2017 May 5.
    Department of Radiology, University of California San Diego, 200 West Arbor Drive, Mail Code: 8756, San Diego, CA 92130, USA.
    Lipomatous lesions are common musculoskeletal lesions that can arise within the soft tissues, bone, neurovascular structures, and synovium. The majority of these lesions are benign, and many of the benign lesions can be diagnosed by radiologic evaluation. However, radiologic differences between benign and malignant lipomatous lesions may be subtle and pathologic correlation is often needed. Read More

    Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high-volume institution.
    Int J Urol 2017 May 3. Epub 2017 May 3.
    Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Objectives: To report our institutional experience in the management of adult genitourinary sarcoma.

    Methods: This was a retrospective analysis of data on adult genitourinary sarcoma treated at the West China Hospital, Sichuan University, Chengdu, Sichuan, China from 1985 to 2010. Clinicopathological parameters were analyzed to determine their impact on overall, recurrence-free and metastasis-free survivals. Read More

    Staged management of giant bilateral perinephric adipocytic neoplasms.
    Clin Case Rep 2017 May 23;5(5):621-624. Epub 2017 Mar 23.
    Endocrine and Oncologic SurgeryHospital of the University of PennsylvaniaPhiladelphiaPennsylvaniaUSA.
    We present a patient with giant bilateral perinephric masses favored to represent liposarcoma preoperatively. Bilateral renal involvement posed a clinical challenge; careful histologic assessment and surgical planning allowed preservation of renal function. Read More

    Hypercellular round cell liposarcoma: A comprehensive cytomorphologic study and review of 8 cases.
    J Cytol 2017 Apr-Jun;34(2):78-83
    Department of Surgery, Radiation and Clinical Oncology, Government Medical College, Haldwani, Uttarakhand, India.
    Background: Myxoid and round cell liposarcomas (RCL) are low and high-grade counterparts of a common subtype of liposarcomas (LPS), representing a histologic continuum.

    Aims: The aim was to study the cytomorphology of hypercellular RCL and to look for features that differentiate RCL from other sarcomas displaying round cells with myxoid change.

    Materials And Methods: Eight cases of hypercellular RCL were identified retrospectively in which round cell component constituted greater than 75% of the area. Read More

    Clinical efficacy of eribulin mesylate for the treatment of metastatic soft tissue sarcoma.
    Expert Opin Pharmacother 2017 Jun;18(8):819-824
    a Early Phase Trials and Sarcoma Units , Institut Bergonié , Bordeaux , France.
    Introduction: Metastatic soft tissue sarcoma, a devastating disease, has a median overall survival of only 12-18 months. Treatment options remain scarce. However, eribulin mesylate, a first-in-class halichondrin B-based microtubule dynamics inhibitor, has recently been approved for the management of patients with advanced liposarcoma. Read More

    A Rare Case of Hibernoma Occasionally Identified by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Patient with Lung Cancer.
    Cureus 2017 Mar 29;9(3):e1124. Epub 2017 Mar 29.
    PET/CT center, Affidea IRMET - Turin - Italy.
    Hibernoma is a benign tumor arising from brown fat tissue. Conventional imaging techniques are not able to differentiate it from other benign lesions or malignant fatty tumors. We report the case of a 73-year-old patient who underwent a thorax computed tomography (CT) and was then referred to our department for metabolic assessment of a solitary lung nodule. Read More

    [Clinical study on the relationship between pancreatic fistula and the degree of pancreatic fibrosis after pancreatic and duodenal resection].
    Zhonghua Wai Ke Za Zhi 2017 May;55(5):373-377
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China.
    Objective: To explore the risk factors of pancreatic fistula after pancreatoduodenectomy and its relationship with pancreatic fibrosis. Methods: Retrospective analysis was made including 408 patients who underwent pancreaticoduodenectomy from January 2013 to December 2015 in Department of Hepatobiliary Surgery of the First Affiliated Hospital of Third Military Medical University. There were 274 males and females, aging from 14 to 82 years with an average age of 54. Read More

    T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas.
    Cancer 2017 May 2. Epub 2017 May 2.
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    Background: Patients with metastatic sarcomas have poor outcomes and although the disease may be amenable to immunotherapies, information regarding the immunologic profiles of soft tissue sarcoma (STS) subtypes is limited.

    Methods: The authors identified patients with the common STS subtypes: leiomyosarcoma, undifferentiated pleomorphic sarcoma (UPS), synovial sarcoma (SS), well-differentiated/dedifferentiated liposarcoma, and myxoid/round cell liposarcoma. Gene expression, immunohistochemistry for programmed cell death protein (PD-1) and programmed death-ligand 1 (PD-L1), and T-cell receptor Vβ gene sequencing were performed on formalin-fixed, paraffin-embedded tumors from 81 patients. Read More

    Review of past and present clinical cases with a view to future treatment options.
    Future Oncol 2017 Jun 2;13(13s):11-28. Epub 2017 May 2.
    Department of Medical Oncology, Centre Leon Berard, Lyon, France.
    In the 10 years that have elapsed since trabectedin was first granted approval in Europe for treatment of advanced soft tissue sarcoma (STS), other cytotoxic agents and targeted therapies have been approved and numerous randomized controlled trials have been completed or are underway. As an academic exercise and positive proof of the advances in STS management that have occurred during the past decade, it is interesting to compare current and future treatment approaches. In this review, present and future treatment approaches are examined by case study for three STS subtypes: uterine leiomyosarcoma, abdominal dedifferentiated liposarcoma and malignant solitary fibrous tumor. Read More

    Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.
    PLoS Genet 2017 May 1;13(5):e1006716. Epub 2017 May 1.
    Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
    Liposarcoma is an often fatal cancer of fat cells. Mechanisms of liposarcoma development are incompletely understood. The cleavage of fatty acids from acylglycerols (lipolysis) has been implicated in cancer. Read More

    Paratesticular Soft-Tissue Masses in Orchiectomy Specimens: A 17-Year Survey of Primary and Incidental Cases From One Institution.
    Int J Surg Pathol 2017 Apr 1:1066896917707040. Epub 2017 Apr 1.
    1 Indiana University School of Medicine, Indianapolis, IN, USA.
    The paratestis (PT) is defined by the testicular tunics, epididymis, spermatic cord, rete testis, and embryonic remnants. It gives rise to a large diversity of pathologies, including those of soft tissue, which may prompt orchiectomy. We performed a 17-year search of our database for orchiectomies for a PT soft-tissue mass. Read More

    Current management of liposarcoma of the spermatic cord: A case report and review of the literature.
    Mol Clin Oncol 2017 Mar 6;6(3):438-440. Epub 2017 Feb 6.
    Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
    Liposarcomas of the spermatic cord, a rare cause of an inguinal mass, may closely mimic inguinal hernias on clinical examination. However, these tumors require a different surgical approach and treatment plan; therefore, intraoperative diagnosis might complicate patient management. We report the case of a 63-year-old man who presented with a mobile mass in the inguinal canal consistent with an inguinal hernia. Read More

    Resectable primary pleural myxoid liposarcoma with a pedicle: report of a rare case and literature review.
    J Thorac Dis 2017 Mar;9(3):E183-E187
    Department of Radiology, People's Hospital of Taierzhuang District, Taierzhuang 277400, China.
    Primary pleural myxoid liposarcoma is a rare tumor. Here, we report a primary myxoid liposarcoma occupying the majority of the left thoracic cavity with features suggesting invasion. Computed tomography (CT) at medical check-up incidentally revealed a bulky inhomogeneous fatty mass. Read More

    Recent translational research into targeted therapy for liposarcoma.
    Stem Cell Investig 2017 15;4:21. Epub 2017 Mar 15.
    International Medical School, Tianjin Medical University, Tianjin 300061, China.
    Liposarcomas (LPS) are among the most common soft tissue sarcomas, originating from adipocytes. Treatment for LPS typically involves surgical resection and radiation therapy, while the use of conventional cytotoxic chemotherapy for unresectable or metastatic LPS remains controversial. This review summarizes the results of recent translational research and trials of novel therapies targeting various genetic and molecular aberrations in different subtypes of LPS. Read More

    Trichoscopic Patterns in Squamous Cell Carcinoma: : A Case Report.
    Int J Trichology 2016 Oct-Dec;8(4):191-194
    Department of Pathology, S Nijalingappa Medical College, Bagalkot, Karnataka, India.
    Squamous cell carcinoma (SCC) is the second most cutaneous malignancy after basal cell carcinoma (BCC) with increasing incidence. In the view its nodular manifestation; it can appear similar to nodular BCC, atypical fibroxanthoma, sclerosing liposarcoma and desmoplastic melanoma. Prognostic and therapeutic implications are different in all these conditions and thus their distinction becomes important. Read More

    Supraclavicular Metastases from Distant Primary Solid Tumours: A Retrospective Study of 41 Years.
    J Maxillofac Oral Surg 2017 Jun 18;16(2):152-157. Epub 2016 May 18.
    Department of Oral and Maxillofacial Surgery - Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
    Objectives: Approximately 1 % of all malignant solid tumours of the head and neck area are metastases from primary tumours beneath the clavicles. The aim of this study was to analyse the distribution of primary tumours since meta-analyses might have been biased due to the usually extraordinary character of case reports.

    Materials And Methods: All patient files from 1970 to 2012 from the Oral and Maxillofacial Surgery unit at a University Hospital were analysed regarding the existence of metastases to the head and neck area from distant primaries. Read More

    Magnetic Resonance Imaging Assessment of Lipomatous Soft-tissue Tumors.
    In Vivo 2017 May-Jun;31(3):387-395
    Department of Medicine, Radiology Unit, University of Padova, Padua, Italy.
    Aim: To establish the accuracy of magnetic resonance imaging (MRI) in distinguishing between benign and malignant lipomatous tumors; to evaluate the reproducibility of the MRI interpretation assessing the agreement between judgments of two radiologists with the same experience in soft-tissue sarcomas; to identify an association among MRI findings (size, depth, septa, nodules, signal homogeneity) and nature of the lesion.

    Materials And Methods: A total of 54 patients (28 men and 26 women), with a mean age of 56 (range=27-84) were included years. All subjects followed-up by the Multidisciplinary Sarcoma Group. Read More

    Mediastinal liposarcoma in a 30-year-old woman with dyspnea and chest pain.
    Respir Med Case Rep 2017 6;21:86-88. Epub 2017 Apr 6.
    Hospital Universitario Central de Asturias (HUCA), Avda de Roma s/n, 33011 Oviedo, Spain.
    Mediastinal liposarcoma (ML) is a rare mesenchymal tumor, accounting for less than 1% of mediastinal tumors. They have a slow growth, so they may not give symptoms for a long time, until the tumor produces compression of close structures. The treatment of choice is surgery, which can be combined with chemo-radiotherapy. Read More

    Predictive and prognostic factors associated with soft tissue sarcoma response to chemotherapy: a subgroup analysis of the European Organisation for Research and Treatment of Cancer 62012 study.
    Acta Oncol 2017 Jul 21;56(7):1013-1020. Epub 2017 Apr 21.
    d Royal Marsden Hospital , London , UK.
    Background: The European Organization for Research and Treatment of Cancer (EORTC) 62012 study was a Phase III trial of doxorubicin versus doxorubicin-ifosfamide chemotherapy in 455 patients with advanced soft tissue sarcoma (STS). Analysis of the main study showed that combination chemotherapy improved tumor response and progression-free survival, but differences in overall survival (OS) were not statistically significant. We analyzed factors prognostic for tumor response and OS, and assessed histological subgroup and tumor grade as predictive factors to identify patients more likely to benefit from combination chemotherapy. Read More

    Clinical genomic profiling to identify actionable alterations for investigational therapies in patients with diverse sarcomas.
    Oncotarget 2017 Apr 5. Epub 2017 Apr 5.
    Department of Investigational Cancer Therapeutics (A Phase I Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
    Background: There are currently no United States Food and Drug Administration approved molecularly matched therapies for sarcomas except gastrointestinal stromal tumors. Complicating this is the extreme diversity, heterogeneity, and rarity of these neoplasms. Few therapeutic options exist for relapsed and refractory sarcomas. Read More

    Next generation sequencing of extraskeletal myxoid chondrosarcoma.
    Oncotarget 2017 Mar;8(13):21770-21777
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Extraskeletal myxoid chondrosarcoma (EMC) is an indolent translocation-associated soft tissue sarcoma with a high propensity for metastases. Using a clinical sequencing approach, we genomically profiled patients with metastatic EMC to elucidate the molecular biology and identify potentially actionable mutations. We also evaluated potential predictive factors of benefit to sunitinib, a multi-targeted tyrosine kinase inhibitor with reported activity in a subset of EMC patients. Read More

    MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas.
    Oncotarget 2017 Mar 17. Epub 2017 Mar 17.
    Institut National de la Santé et de la Recherche Medicale, Institut Bergonié, Bordeaux, France.
    Background: Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) are characterized by a consistent amplification of the MDM2 gene. The PI3K/AKT/mTOR pathway has been suggested to play also an important role in their tumorigenesis. Our goal was to determine whether combined MDM2 and PI3K/AKT/mTOR targeting is associated with higher anti-tumor activity than single agent alone in preclinical models of WDLPS/DDLPS. Read More

    Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas.
    J Hematol Oncol 2017 Apr 11;10(1):84. Epub 2017 Apr 11.
    INSERM ACTION U1218, Institut Bergonié, 229 cours de l'Argonne, 33076, Bordeaux cedex, France.
    Background: Trabectedin has recently been approved in the USA and in Europe for advanced soft-tissue sarcoma patients who have been treated with anthracycline-based chemotherapy without success. The mechanism of action of trabectedin depends on the status of both the nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways. Trabectedin results in DNA double-strand breaks. Read More

    Well-differentiated Liposarcoma in a Bonnet Macaque (Macaca radiata).
    Comp Med 2017 Mar;67(2):176-179
    University Animal Care, University of Arizona, Tucson, Arizona.
    Here we describe the occurrence of a subcutaneous liposarcoma in a geriatric bonnet macaque (Macaca radiata). Clinical presentation was a rapidly growing, ulcerated, subcutaneous mass in the umbilical region of a 28-y-old intact female macaque. The mass was successfully removed through excisional biopsy, and histopathology provided a morphologic diagnosis of well-differentiated liposarcoma. Read More

    Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review.
    Case Rep Pathol 2017 9;2017:2346316. Epub 2017 Mar 9.
    Department of Pathology, APHM, Marseille, France.
    Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine. The authors present the case of a 67-year-old man with progressive history of back pain. Physical examination revealed a mass located within the right paravertebral muscles. Read More

    Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature.
    Neurosurgery 2017 Apr;80(4):219-223
    Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
    Background And Importance: Myxoid liposarcoma is not an uncommon form of sarcoma. However, it usually affects the lower extremity long bones. Scapular involvement is extremely rare, as is a metastasis to the parasellar region. Read More

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