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    Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features.
    Am J Surg Pathol 2017 Jul 20. Epub 2017 Jul 20.
    Departments of *Pathology and Clinical Laboratories §Urology ∥Musculoskeletal Oncology ¶Medical Oncology, National Cancer Center Hospital ‡Rare Cancer Center, National Cancer Center Hospital †Department of Pathology, the University of Tokyo, Tokyo, Japan.
    Dedifferentiated liposarcoma (DDLPS) demonstrates a variety of growth patterns, and their histologic resemblance to other spindle cell mesenchymal tumors has been widely recognized. However, epithelioid morphology in DDLPS has only rarely been documented. Here, we report 6 cases of DDLPS with striking epithelioid/epithelial features. Read More

    A novel sclerosing atypical lipomatous tumor/well-differentiated liposarcoma in a 7-year-old girl: Report of a case with molecular confirmation.
    Hum Pathol 2017 Jul 10. Epub 2017 Jul 10.
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:
    Atypical lipomatous tumor/well-differentiated liposarcoma/dedifferentiated liposarcoma (ALT/WDL/DDL) is a common type of liposarcoma in late adulthood. However, pediatric ALT/WDL/DDL is extremely rare, and only 3 cases have been described in children younger than 10years of age. Notably, none of these cases harbored MDM2 gene amplification. Read More

    [Histology-Specific Chemotherapy in Soft-Tissue Sarcomas].
    Gan To Kagaku Ryoho 2017 Jun;44(6):468-472
    Division of Musculoskeletal Oncology, National Cancer Center Hospital.
    Soft-tissue sarcomas(STSs)are rare mesenchymal tumors, accounting for less than 1%of all adult malignancies. STSs also have diversity, with more than 50 different histological subtypes. While surgical complete resection is a definitive treatment for localized STS, chemotherapy is the treatment option for managing locally advanced and metastatic STS. Read More

    [The Role of Novel Agents in the Treatment of Soft Tissue Sarcoma].
    Gan To Kagaku Ryoho 2017 Jun;44(6):463-467
    Division of Breast and Medical Oncology, National Cancer Center Hospital East.
    Soft tissue sarcomas are rare disease and the development of efficacious drug is urgently needed. The challenge is continuing, and recently 2 drugs, trabectedin and eribulin, were approved in Japan. Both drugs were investigated in patients with liposarcoma or leiomyosarcoma in randomized phase III trials as compared to dacarbazine. Read More

    [Molecular Target Therapy for Soft Tissue Sarcoma].
    Gan To Kagaku Ryoho 2017 Jun;44(6):457-462
    Dept. of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research.
    Soft tissue sarcoma(STS)is one of the rare and intractable cancers, and most types of STS are not sensitive to chemotherapy. Development of specific molecular target therapy for each type of STS is necessary. There are specific chromosome translocations in 20-30% of STS, but their products are mostly transcriptional factors, and target therapy for those factors are difficult to develop. Read More

    The effect of radiotherapy on fat content and fatty acids in myxoid liposarcomas quantified by MRI.
    Magn Reson Imaging 2017 Jul 8;43:37-41. Epub 2017 Jul 8.
    Department of Medical Radiation Physics, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
    Background: Myxoid liposarcomas are highly radiosensitive. Consequently radiotherapy is often used pre-operatively to reduce tumor volume and lessen the post-operative deficit. In soft-tissue sarcomas therapy response is mainly evaluated using magnetic resonance imaging (MRI) and the fundamental criterion for a positive response is decreased tumor size. Read More

    [A Case of Dedifferentiated Liposarcoma of the Spermatic Cord].
    Hinyokika Kiyo 2017 Jun;63(6):251-254
    The Department of Urology, Nippon Medical School Hospital.
    A 63-year-old man was referred to our department because of painless hard mass in the right inguinal region. Abdominal computed tomography (CT) showed right spermatic cord mass measuring 25 mm in diameter. We performed right high orchiectomy. Read More

    PD-1 and PD-L1 expression in bone and soft tissue sarcomas.
    Pathology 2017 Aug 5;49(5):506-513. Epub 2017 Jul 5.
    Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States.
    PD-1 and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the Unites States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for treatment of non-small cell lung carcinoma and recently expanded the use of immunotherapy for metastatic urothelial cell carcinoma and Hodgkin lymphoma. However, studies on expression of PD-1 and its ligand in malignant bone and soft tissue sarcoma are sparse. Read More

    Breast liposarcoma with solitary metastasis to the pleura: A case report.
    Medicine (Baltimore) 2017 Jul;96(27):e7340
    aDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine bDepartment of Medical Oncology, Zhejiang Cancer Hospital cDepartment of Medical Oncology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University dDepartment of Pathology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
    Rationale: Breast cancer is the most prevalent malignancy in women worldwide. Our patient presented with a history of breast liposarcoma (LPS) and was found to have pleural metastasis during the initial workup.

    Patient Concerns: The patient was complaining about chest pain and dyspnea that had persisted for a week. Read More

    Successful treatment of advanced pancreatic liposarcoma with apatinib: A case report and literature review.
    Cancer Biol Ther 2017 Jul 5. Epub 2017 Jul 5.
    a Department of Oncology , Cancer center of People's Liberation Army, General Hospital of Shenyang Military Region , Shenyang 110840 , P.R.China.
    Pancreatic liposarcoma is a malignant tumor originated from the pancreas mesenchymal tissue and mostly presented in skin, subcutaneous, periosteum, and long bone on both sides. Both conventional chemotherapy and radiotherapy have limited efficacy and poor prognosis for advanced pancreatic liposarcoma. Here, we reported a case of advanced pancreatic liposarcoma and reviewed the literature specific for liposarcoma of the pancreas and discuss the emerging options of treatment. Read More

    Unusual Asymptomatic Fluorodeoxyglucose Avid Pheochromocytoma in a Case of Myxoid Liposarcoma of the Extremity on (18)-F Fluorodeoxyglucose Positron Emission Tomography-computed Tomography.
    World J Nucl Med 2017 Jul-Sep;16(3):237-239
    Nuclear Healthcare Ltd., Kopar Khairane, Navi Mumbai, Mumbai, Maharashtra, India.
    Sarcomas are a heterogeneous group of rare tumors and arise either from soft tissue or from bone. Soft-tissue sarcomas (STSs) initially metastasize to the lungs. Metastases to extrapulmonary sites such as liver, brain, and soft tissue distant from primary tumor usually develop later. Read More

    Identification of key genes and molecular mechanisms associated with dedifferentiated liposarcoma based on bioinformatic methods.
    Onco Targets Ther 2017 16;10:3017-3027. Epub 2017 Jun 16.
    Department of Radiation Oncology, Yancheng Third People's Hospital, Yancheng, Jiangsu, People's Republic of China.
    Background: Dedifferentiated liposarcoma (DDLPS) is one of the most deadly types of soft tissue sarcoma. To date, there have been few studies dedicated to elucidating the molecular mechanisms behind the disease; therefore, the molecular mechanisms behind this malignancy remain largely unknown.

    Materials And Methods: Microarray profiles of 46 DDLPS samples and nine normal fat controls were extracted from Gene Expression Omnibus (GEO). Read More

    Extra-adrenal myelolipoma and extramedullary hematopoiesis: Imaging features of two similar benign fat-containing presacral masses that may mimic liposarcoma.
    Eur J Radiol 2017 Aug 29;93:185-194. Epub 2017 May 29.
    Department of Radiology, Mayo Clinic, Rochester, MN, United States; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States.
    Objective: To describe the imaging characteristics of extra-adrenal myelolipoma and mass-forming extramedullary hematopoiesis (EMH) occurring in the presacral region.

    Materials And Methods: Retrospective review between 1980 and 2015 revealed 11 patients with biopsy-proven presacral extra-adrenal myelolipoma and 11 patients with presacral EMH and radiologic imaging studies.

    Results: All cases of both myelolipoma and EMH directly abutted the anterior sacrum and were centered on the midline. Read More

    Interleukin-6, C/EBP-β and PPAR-γ expression correlates with intramuscular liposarcoma growth in mice: The impact of voluntary physical activity levels.
    Biochem Biophys Res Commun 2017 Aug 28;490(3):1026-1032. Epub 2017 Jun 28.
    EA1274 Laboratory "Movement, Sport and Health Sciences" M2S, University of Rennes 2-ENS Rennes, 35170 Bruz, France. Electronic address:
    IL-6 is an axial cytokine overexpressed in cancer to promote growth and increase resistance to anti-cancer therapies. As the application of IL-6-targeting therapies are still limited, alternative non-aggressive and adjuvant approaches, like physical activity (PA) could be useful to reverse IL-6 effects. To get more insights into liposarcoma (LS) pathophysiology, we investigated potential molecular links between IL-6 and LS growth and we tested the impact of PA on such mechanism in an orthotopic model of intramuscular LS. Read More

    High-Throughput Screening of Myxoid Liposarcoma Cell Lines: Survivin Is Essential for Tumor Growth.
    Transl Oncol 2017 Jun 24;10(4):546-554. Epub 2017 Jun 24.
    Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:
    Myxoid liposarcoma (MLS) is a soft tissue sarcoma characterized by a recurrent t(12;16) translocation. Although tumors are initially radio- and chemosensitive, the management of inoperable or metastatic MLS can be challenging. Therefore, our aim was to identify novel targets for systemic therapy. Read More

    Scattered genomic amplification in dedifferentiated liposarcoma.
    Mol Cytogenet 2017 24;10:25. Epub 2017 Jun 24.
    Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, SE-221 84 Lund, Sweden.
    Background: Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations than supernumerary ring or giant marker chromosomes, although DDLS tend to have somewhat more complex rearrangements. In contrast, pleomorphic liposarcomas (PLS) have highly aberrant and heterogeneous karyotypes. The ring and giant marker chromosomes contain discontinuous amplicons, in particular including multiple copies of the target genes CDK4, HMGA2 and MDM2 from 12q, but often also sequences from other chromosomes. Read More

    Efficacy and safety of trabectedin or dacarbazine in patients with advanced uterine leiomyosarcoma after failure of anthracycline-based chemotherapy: Subgroup analysis of a phase 3, randomized clinical trial.
    Gynecol Oncol 2017 Jun 23. Epub 2017 Jun 23.
    Dana-Farber Cancer Institute, Harvard Medical School, and Ludwig Center at Harvard, Boston, MA, USA. Electronic address:
    Objective: Trabectedin demonstrated significantly improved disease control in leiomyosarcoma and liposarcoma patients in a global phase 3 trial (NCT01343277). A post hoc analysis was conducted to assess the efficacy and safety of trabectedin or dacarbazine in women with uterine leiomyosarcoma (uLMS), the largest subgroup of enrolled patients (40%).

    Methods: Of 577 patients randomized 2:1 to receive trabectedin 1. Read More

    FUS-DDIT3 fusion protein driven IGF-IR signaling is a therapeutic target in myxoid liposarcoma.
    Clin Cancer Res 2017 Jun 21. Epub 2017 Jun 21.
    Institute of Pathology, University Hospital Muenster.
    Purpose: Myxoid liposarcoma is an aggressive disease with particular propensity to develop hematogenic metastases. Over 90% of myxoid liposarcoma are characterized by a reciprocal t(12;16)(q13;p11) translocation. The resulting chimeric FUS-DDIT3 fusion protein plays a crucial role in myxoid liposarcoma pathogenesis; however, its specific impact on oncogenic signaling pathways remains to be substantiated. Read More

    [An analysis of incidence trends and characteristics of soft tissue sarcoma in Beijing, 1999-2013].
    Zhonghua Zhong Liu Za Zhi 2017 Jun;39(6):471-476
    Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing Office for Cancer Prevention and Control.
    Objective: To analyze the incidence trends and to describe the characteristics of soft tissue sarcoma (STS) among residents in Beijing from 1999 to 2013. Methods: Medical information of the cases diagnosed as STS(ICD10: C47&C49) from 1999 to 2013 in Beijing was extracted from the population-based database of Beijing Cancer Registry.Crude incidence rate, age-standardized incidence rates to Chinese population (ASRC)and the world population(ASRW) were calculated. Read More

    Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature.
    Case Rep Orthop 2017 29;2017:3025084. Epub 2017 May 29.
    Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
    Background: Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. Recently, some authors have reported that MD genes are related to neoplastic formation, but there have been no detailed clinical reports of ALT associated with MD. Read More

    Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas.
    J Hematol Oncol 2017 Jun 19;10(1):123. Epub 2017 Jun 19.
    Institut National de la Santé et de la Recherche Medicale (INSERM) U1218, Institut Bergonié, 229 cours de l'Argonne, 33076, Bordeaux cedex, France.
    Purpose: MDM2 and CDK4 are frequently co-amplified in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS). We aimed to determine whether combined MDM2/CDK4 targeting is associated with higher antitumour activity than a single agent in preclinical models of DDLPS.

    Experimental Design: DDLPS cells were exposed to RG7388 (MDM2 antagonist) and palbociclib (CDK4 inhibitor), and apoptosis and signalling/survival pathway perturbations were monitored by flow cytometry and Western blotting. Read More

    Eribulin in advanced liposarcoma and leiomyosarcoma.
    Expert Rev Anticancer Ther 2017 Aug 28;17(8):717-723. Epub 2017 Jun 28.
    b Sarcoma Unit , Royal Marsden NHS Foundation Trust , London , UK.
    Introduction: The heterogeneity of soft tissue sarcomas (STS) presents a formidable management challenge. Consequently, one of the main research goals is to define specific tailored therapy for each histological subtype and to develop a more personalised approach to treatment. The standard first line chemotherapy for advanced STS is doxorubicin, with or without ifosfamide, however, a number of different drugs are emerging as active therapies beyond first-line. Read More

    Neoadjuvant chemotherapy in soft tissue sarcomas: latest evidence and clinical implications.
    Ther Adv Med Oncol 2017 Jun 16;9(6):415-429. Epub 2017 Apr 16.
    Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, 20013 Milano, Italy.
    Soft tissue sarcomas are a rare and multifaceted group of solid tumours. Neoadjuvant chemotherapy is increasingly used to limit loss of function after wide surgical excision with the ultimate aim of improving patient survival. Recently, advances in the identification of effective treatment strategies and improvements in patient risk stratification have been reached. Read More

    Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years.
    BMC Cancer 2017 Jun 12;17(1):410. Epub 2017 Jun 12.
    Department of Orthopedics and Sports Orthopedics, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
    Background: Soft tissue sarcomas are rare entities with over 50 histological subtypes. Liposarcoma (LS) is the most common neoplasm in this group; it is a complex neoplasm that is divided into different histological subtypes. Different therapy options, such as surgical resection, radiation, and chemotherapy, are available. Read More

    Well-differentiated liposarcoma with chondroid metaplasia in the auricle of a dog.
    J Vet Med Sci 2017 Jul 11;79(7):1236-1239. Epub 2017 Jun 11.
    Department of Veterinary Pathology, Tottori University, Tottori, Tottori 680-8553, Japan.
    A 13-year-old spayed female dog had a mass in the left auricle. Grossly, connection between the mass and original auricular cartilage was not recognized. The mass was unencapsulated and contained multiple islands of mature hyaline cartilage and neoplastic adipocytes. Read More

    Neuropraxia following resection of a retroperitoneal liposarcoma.
    Int J Surg Case Rep 2017 1;36:170-174. Epub 2017 Jun 1.
    Texas Tech University Health Sciences Center, Department of Surgery, 1400 S. Coulter Street, Amarillo, TX 79106, United States. Electronic address:
    Background: This is a unique case of neuropraxia of femoral nerve seen after resection of retroperitoneal liposarcoma which has not been reported before in the literature.

    Introduction: Neuropraxia, a transient paralysis due to blockage of nerve conduction, commonly associated with athletes and orthopedic procedures, has not been previously reported as a complication following resection of retroperitoneal sarcoma.

    Case: This is an 81-year-old female who, on CT for evaluation of her atherosclerosis, was found to have an incidental right-sided retroperitoneal mass extending from the right renal capsule inferiorly through the inguinal canal. Read More

    Statistics of soft-tissue sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan.
    J Orthop Sci 2017 Jul;22(4):755-764
    Department of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:
    Background: No previous reports to date have characterized the national profiles of soft-tissue sarcomas (STSs). In the present study, we reviewed current practice for STSs in Japan using data from a nationwide organ-specific cancer registry for bone and soft-tissue tumors in Japan, the Bone and Soft Tissue Tumor (BSTT) Registry.

    Methods: In the registry, we identified 8228 patients with STSs during the period 2006-2012, and extracted data on patient demographics, treatment, and outcome at the last follow-up for each patient. Read More

    Paraspinal hibernoma: Grand Round presentation of a rare benign adipocytic tumor.
    Eur Spine J 2017 Jun 7. Epub 2017 Jun 7.
    Department of Spinal Surgery Unit 1, Bordeaux University Hospital, Université de Bordeaux, C.H.U Tripode Pellegrin, Place Amélie Raba Léon, 33076, Bordeaux, France.
    Introduction: We report an uncommon case of paraspinal hibernoma with a T12-L1 foraminal extension and discuss the potential differential diagnoses of paraspinal adipocytic tumors.

    Materials And Methods: A 32-year-old woman consulted our department with a right subscapular and paraspinal mass. There was no associated neurological deficit. Read More

    Cutaneous sarcomas.
    J Dtsch Dermatol Ges 2017 Jun;15(6):630-648
    Department of Dermatology and Allergology, Munich Technical University, Munich, Germany.
    Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

    Kutane Sarkome.
    J Dtsch Dermatol Ges 2017 Jun;15(6):630-649
    Klinik und Poliklinik für Dermatologie und Allergologie, Technische Universität München.
    Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include a typical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

    Results of a Qualitative Study to Develop a Patient Reported Outcome Measure for Patients with 4 Subtypes of Soft Tissue Sarcoma.
    Sarcoma 2017 14;2017:6868030. Epub 2017 May 14.
    Evidera, Bethesda, MD, USA.
    Objective: The objective of this research was to develop a disease-specific symptom inventory for soft tissue sarcoma.

    Methods: Literature review and clinical expert and patient interviews were conducted to determine disease-specific symptoms important to patients with one of the four STS subtypes. Clinical experts identified the most relevant STS symptom items from the item pool developed from literature review. Read More

    Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.
    Cancer Res 2017 Jul 6;77(14):3846-3856. Epub 2017 Jun 6.
    The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
    Despite the development of combined modality treatments against liposarcoma in recent years, a significant proportion of patients respond only modestly to such approaches, possibly contributing to local or distant recurrence. Early detection of recurrent or metastatic disease could improve patient prognosis by triggering earlier clinical intervention. However, useful biomarkers for such purposes are lacking. Read More

    Imaging features of mammary-type myofibroblastoma of soft tissue: a case series with literature review.
    Skeletal Radiol 2017 Sep 1;46(9):1283-1291. Epub 2017 Jun 1.
    Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA.
    Mammary-type myofibroblastoma (MTM) is a rare, benign neoplasm that is histologically identical to myofibroblastoma of the breast, but occurring in an extramammary site. The masses have been reported in superficial and deep soft tissue sites and visceral locations with the inguinal area and lower extremities are the most common. Most previous reports of MTMs have concentrated on clinical and pathological findings, with very limited information regarding imaging characteristics. Read More

    In vivo antitumoral efficacy of PhAc-ALGP-doxorubicin, an enzyme-activated doxorubicin prodrug, in patient-derived soft tissue sarcoma xenograft models.
    Mol Cancer Ther 2017 May 31. Epub 2017 May 31.
    Laboratory of Experimental Oncology, Department of Oncology, KU Leuven and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven
    Given the very limited efficacy of doxorubicin (doxo) in soft tissue sarcoma, there is a clear need for more active and less toxic treatments for this family of diseases. However, due to the rarity of these malignancies and lack of reliable preclinical models, development of new therapies has lagged behind.

    We evaluated the efficacy of PhAc-ALGP-doxorubicin (ALGP-doxo), a prodrug metabolized to doxo by peptidases present in tumor cells and/or tumor microenvironment, in a synovial sarcoma (SynSa) and two dedifferentiated liposarcoma (DDLPS) patient-derived xenograft models. Read More


    Maintaining a regular physical activity aggravates intramuscular tumor growth in an orthotopic liposarcoma model.
    Am J Cancer Res 2017 1;7(5):1037-1053. Epub 2017 May 1.
    EA1274 Laboratory "Movement, Sport and Health Sciences" M2S, University of Rennes 2-ENS RennesBruz 35170, France.
    Today, care teams within cancer centers encourage patients to be physically active, after diagnosis, based on data obtained mainly from breast, colon and prostate cancer. Intriguingly, the impact of physical activity (PA) on intramuscular tumors (e.g. Read More

    Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma.
    Pathol Res Pract 2017 Jun 1;213(6):634-638. Epub 2017 May 1.
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. Electronic address:
    It is important to distinguish between leiomyosarcoma (LMS) and dedifferentiated liposarcoma (DDLS) in the retroperitoneum. The dedifferentiated component of DDLS shows an LMS-like morphology in some cases; thus, detailed evaluation is necessary to achieve an accurate diagnosis. Immunohistochemically, MDM2 and myogenic markers provide clues for the diagnoses. Read More

    Preoperative vs postoperative radiation therapy in localized soft tissue sarcoma: Nationwide patterns of care and trends in utilization.
    Pract Radiat Oncol 2017 Apr 18. Epub 2017 Apr 18.
    Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:
    Purpose: The timing of perioperative radiation therapy (RT) in the treatment of soft tissue sarcoma (STS) varies among institutions. This study examines patterns of care, trends in utilization, and survival with preoperative versus postoperative RT for primary STS.

    Methods And Materials: Using the National Cancer Data Base, we identified patients with stage I-III STS who underwent definitive surgery with either preoperative or postoperative RT between 2004 and 2012. Read More

    Systemic Therapy for Soft Tissue Sarcoma: Proposals for the Optimal Use of Pazopanib, Trabectedin, and Eribulin.
    Adv Ther 2017 Jul 25;34(7):1556-1571. Epub 2017 May 25.
    Department of Orthopaedic Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
    Soft tissue sarcoma (STS) is a rare tumor with more than 50 histologic subtypes. Although treatment outcomes for patients with STS have improved greatly over the past few decades owing to the adoption of a multidisciplinary approach, patients with advanced disease have a poor prognosis. The development of anticancer drugs has been directed toward improving overall survival (OS). Read More

    Lipoblasts in Spindle Cell and Pleomorphic Lipomas: a Close Scrutiny.
    Hum Pathol 2017 May 22. Epub 2017 May 22.
    Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
    The presence and frequency of lipoblasts (LPB) in spindle cell lipomas (SCL) and pleomorphic lipomas (PL) has never been studied in detail on histologically, immunohistochemically and molecular genetically validated set of tumors. The authors investigated this feature by reviewing 91 cases of SCL and 38 PL. When more than three unequivocal LPB were found, the case was regarded as positive for the presence of LPB. Read More

    Fine needle aspiration cytology findings of myxoinflammatory fibroblastic sarcoma: A case report.
    Diagn Cytopathol 2017 May 24. Epub 2017 May 24.
    Department of Molecular and Cellular Pathology, Kanazawa University, Kanazawa, Japan.
    Myxoinflammatory fibroblastic sarcoma (MIFS) is rare low-grade soft-tissue tumor that occurs in extremities. Clinically it is difficult to differentiate from benign lesions, such as nodular fasciitis, and malignant tumors, such as liposarcoma. We report a case of MIFS in the forearm of a 34-year-old man. Read More

    Metastasis of soft tissue sarcomas in lymph node. A cytomorphological study.
    Diagn Cytopathol 2017 May 24. Epub 2017 May 24.
    Department of Pathology, Gujarat Cancer And Research Institute (GCRI), Ahmedabad, Gujarat, India.
    Background: Soft-tissue sarcoma (STS) rarely metastasizes to lymph node compared to carcinoma. Fine-needle aspiration cytology (FNAC) carries a pivotal role in diagnosis of metastatic tumor to lymph node. This study highlights the role of FNAC in diagnosis of STS metastasis to lymph node. Read More

    Elevated NDC80 expression is associated with poor prognosis in osteosarcoma patients.
    Eur Rev Med Pharmacol Sci 2017 May;21(9):2045-2053
    Department of Orthopedics, Shandong Energy Zaozhuang Mining Group Center Hospital, Shandong, China.
    Objective: Osteosarcoma (OS) is a commonly diagnosed bone malignancy in children and adolescents. Nuclear division cycle 80 (NDC80) is a crucial regulator of the cell division cycle that has recently been identified as a novel oncoprotein in various solid tumors; however, its role in OS remains poorly understood. The aim of this study was to investigate correlations between NDC80 expression in OS patients and clinicopathological features and prognosis. Read More

    A clinical review of 11 cases of large-sized well-differentiated liposarcomas.
    Eur J Orthop Surg Traumatol 2017 Aug 23;27(6):837-841. Epub 2017 May 23.
    Hospital Clínico San Carlos, Calle Profesor Martín Lagos s/n, 28040, Madrid, Spain.
    Well-differentiated liposarcomas of the extremities are one of the most frequent types of malignant soft tissue tumors in adults. These tumors are typically locally aggressive and show a tendency to recurrence after surgical excision even though they do not metastasize and very rarely dedifferentiate. Its clinical presentation is generally a progressively growing mass causing aesthetic, functional, or compressive symptoms depending on the tumor's size and localization. Read More

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