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    1 OF 127

    Liposarcoma of the spermatic cord in a Toy Poodle.
    J Vet Med Sci 2017 Nov 14. Epub 2017 Nov 14.
    College of Veterinary Medicine, Kyungpook National University.
    Liposarcoma of the spermatic cord is extremely rare in dogs and humans. This report describes the clinical signs, typical diagnostic imaging including ultrasound and computed tomography, and treatment of a liposarcoma of the spermatic cord of a Toy Poodle confirmed by histological examination after a surgical procedure. This case highlights the importance of preoperative diagnostic imaging and histopathological examination in dogs with an inguinal or scrotal mass. Read More

    Liposarcoma of the Spermatic Cord –A Rare Pathological Entity.
    Coll Antropol 2017 Mar;41(1):89-93
    Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Read More

    Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets.
    J Hematol Oncol 2017 Nov 13;10(1):173. Epub 2017 Nov 13.
    Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
    Background: Liposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease. The Achilles heel of cancer often is their kinases that are excellent therapeutic targets. However, very limited knowledge exists of therapeutic critical kinase targets in liposarcoma that could be potentially used in disease management. Read More

    Adipocyte Size Variability in Benign and Malignant Lipomatous Tumors and Morphologic Mimics: a Quantitative Definition Using Digital Pathology.
    Hum Pathol 2017 Nov 8. Epub 2017 Nov 8.
    Department of Pathology, University of San Francisco (UCSF), San Francisco, CA 94143.
    Among well-differentiated lipomatous lesions, variability in adipocyte size has been proposed as a morphologic feature of malignancy. Specifically, normal adipose tissue and benign lipomas tend to contain adipocytes of uniform size, whereas atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) are described as containing adipocytes with a conspicuous variation in cell size. However, this proposed variance has never been objectively, quantitatively correlated with diagnosis. Read More

    A giant mediastinal liposarcoma weighing 3500g resected with clam shell approach, a case report with review of literature.
    Int J Surg Case Rep 2017 Nov 7;41:292-295. Epub 2017 Nov 7.
    Department of General Thoracic Surgery, National Hospital Organization, Kanagawa National Hospital, 666-1 Ochiai Hadano, Kanagawa 257-8585, Japan.
    Introduction: Liposarcoma is rare in the mediastinum and is less than 1% of all mediastinal tumors. In the present report, we demonstrated our case and summarized the principal treatment of the mediastinal liposarcoma with literature review.

    Presentation Of Case: A 50-year-old man presented at our hospital with complain of dyspnea. Read More

    Historical perspectives and future directions in the surgical management of retroperitoneal sarcoma.
    J Surg Oncol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
    Retroperitoneal sarcomas (RPS) have fascinated and intrigued physicians both past and present. Operative mortality rates were historically very high and complete resection was not possible for the majority of patients until only the last 2 decades. More recently, changes to the surgical approach and clinical decision-making in RPS have improved patient outcomes. Read More

    Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
    • Authors:
    • ,
    Cell 2017 Nov;171(4):950-965.e28
    Cancer Genome Atlas Program Office, National Cancer Institute at NIH, 31 Center Drive, Bldg. 31, Suite 3A20, Bethesda, MD 20892, USA.
    Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Read More

    Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification.
    Histopathology 2017 Oct 27. Epub 2017 Oct 27.
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Aims: Ossification is occasionally found in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumor cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification.

    Methods And Results: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. Read More

    [Transhepatic approach for recurrent retroperitoneal liposarcoma].
    Khirurgiia (Mosk) 2017 (10):91-93
    Blokhin Russian Cancer Research Center, Healthcare Ministry of the Russian Federation, Moscow, Russia, Sechenov First Moscow State Medical University of Healthcare Ministry of the Russian Federation, Moscow, Russia, Pirogov Russian Research Medical University of Healthcare Ministry of the Russian Federation, Moscow, Russia.

    [Soft tissue tumors : Epidemiology, classification and staging].
    Radiologe 2017 Nov;57(11):973-986
    Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum des Saarlandes, Kirrbergerstraße, 66424, Homburg/Saar, Deutschland.
    Benign, intermediate and malignant soft tissue tumors can be differentiated histologically. Furthermore, the tumors can be subdivided according to their linear differentiation. In the new World Health Organization (WHO) classification of soft tissue tumors from 2013 changes have been made relating to the allocation of known entities, e. Read More

    Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.
    Redox Biol 2017 Sep 28;14:417-422. Epub 2017 Sep 28.
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:
    Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20mM plasma levels) is a potentially efficacious and easily integrable addition to current standard of care treatment strategies in preclinical models of fibrosarcoma and liposarcoma both in vitro and in vivo. Furthermore, enhanced ascorbate-mediated toxicity and DNA damage in these sarcoma models were found to be dependent upon H2O2 and intracellular labile iron. Read More

    Primary adrenal teratoma: An unusual tumor - Challenges in diagnosis and surgical management.
    J Postgrad Med 2017 Oct 23. Epub 2017 Oct 23.
    Department of Endocrine Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
    We report a rare case of a 25-year-old lady who presented with right hypochondriac pain associated with weakness for 3 months. Her hormonal evaluation was normal. Computed tomography scan revealed an adrenal mass for which a right open transperitoneal adrenalectomy was performed, and the lesion was diagnosed as mature teratoma on histopathological examination. Read More

    Surgical Management of Primary Retroperitoneal Sarcomas: Rationale for Selective Organ Resection.
    Ann Surg Oncol 2017 Oct 24. Epub 2017 Oct 24.
    Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
    Background: Recently, some have argued for routine resection of adjacent but uninvolved organs in patients with retroperitoneal sarcoma (RPS) without stipulating the rationale for such organ resection (beyond the need to achieve a macroscopically complete resection) or examining histopathologic organ invasion (HOI). This study reviewed the authors' experience with primary RPS to investigate the rate and rationale for individual organ resection and the rate of HOI.

    Methods: Operative and pathology reports for patients with primary RPS who underwent resection at our institution were retrospectively reviewed. Read More

    Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model.
    Anticancer Res 2017 11;37(11):6291-6302
    Department of Health Sciences & Technology, Graduate School, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea
    Background/aim: Heat shock protein 90 (HSP90) inhibitors have recently been tested as anticancer drugs in a variety of carcinomas. Yet, there exist only few reports about HSP90 inhibitor and its thepeutic effect on liposarcoma. The therapeutic effects of HSP90 inhibitors have been mainly observed in oncogenic and tumor angiogenic signaling cascades by observing tumor growth. Read More

    A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report.
    Mol Clin Oncol 2017 Oct 18;7(4):539-542. Epub 2017 Aug 18.
    Department of Pathology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
    Sarcoma is an uncommon histopathological presentation of sinonasal tumors, comprising ~15% of all cases; liposarcoma is particularly uncommon. An analysis of the available medical literature revealed no prior reports of dedifferentiated liposarcoma (DDLPS) of the sinonasal cavity. This case report presents a rare case of DDLPS of the sinonasal cavity. Read More

    Pedunculated liposarcoma of the esophagus.
    Dis Esophagus 2017 Nov;11(1):68-71
    Cliníca Modelo de Morón, Uruguay 224 Morón Pcia, Buenos Aires, Argentina.
    Polypoid tumours of the esophagus present diagnostic and therapeutic problems. Liposarcomas are infrequent among them. We report a recent case. Read More

    A case of dedifferentiated liposarcoma of the heart and stomach.
    Int J Surg Case Rep 2017 Oct 6;41:36-38. Epub 2017 Oct 6.
    Division of Cardiovascular Surgery, Oita Prefectural Hospital, 476 Bunyo, Oita City, Oita 870-8511, Japan.
    Introduction: Liposarcoma of the heart and stomach is rare.

    Presentaion Of Case: We report a case of liposarcoma in both organs with dedifferentiated histology. A patient was referred to our hospital with anorexia and weight loss. Read More

    TopBP1 promotes malignant progression and correlates with poor prognosis in osteosarcoma.
    Eur Rev Med Pharmacol Sci 2017 Sep;21(18):4022-4031
    Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
    Objective: Topoisomerase IIβ binding protein 1 (TopBP1) is involved in DNA damage and replication checkpoint and has been shown to be related to tumorigenesis in many cancer types. This study aimed to evaluate the biological role and clinicopathological significance of TopBP1 in OS.

    Patients And Methods: TopBP1 expression in sarcoma patients was determined through the Oncomine database, and the prognostic role of TopBP1 expression was assessed in a retrospective cohort study. Read More

    Reconstruction of Liposarcoma Resection Defect With a Made-to-Measure Polyethylene Prosthesis Using Three-Dimensional Digital Technology.
    J Craniofac Surg 2017 Oct 11. Epub 2017 Oct 11.
    *Department of Oral and Maxillofacial Surgery, Donostia University Hospital, San Sebastian †AJL Ophthalmic, Vitoria ‡Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada §Department of General Surgery, Oncology Foundation, San Sebastian ||Department of Special Care in Dentistry, Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada, Spain.
    Background: Liposarcoma is considered one of the most frequently occurring tumors of the soft tissues, representing 17% to 30% of all mesenchymal cell tumors. It is less common in the head and neck representing <10% of tumors in this region. The reconstruction of defects derived from resection of these tumors presents a surgical challenge. Read More

    Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
    Ann Surg Oncol 2017 Dec 11;24(13):3803-3810. Epub 2017 Oct 11.
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
    Background: Isolated limb perfusion (ILP) and isolated limb infusion (ILI) have been variably used in recent years for the treatment of locally advanced or marginally resectable extremity soft tissue sarcomas (STSs). We performed a systematic review and meta-analysis of contemporary studies to further characterize treatment patterns and outcomes.

    Methods: PubMed was queried for articles published in or after the year 2000, in the English language, with > 10 patients, and with adequate outcome data following ILP/ILI. Read More

    Vulvar Myxoid Liposarcoma, an Extremely Rare Diagnosis: A Case Report and Review of Literature.
    Int J Gynecol Pathol 2017 Oct 10. Epub 2017 Oct 10.
    Hospital Metropolitano, Quito, Ecuador.
    Malignant lipomatous tumors of the vulva are an extremely rare entity. We report the case of a 53-year-old patient with a nodule on her right labium majus whose histological and immunohistochemical profile (S100 and p16) confirmed a diagnosis of vulvar myxoid liposarcoma. Read More

    Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan.
    Int J Urol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
    Objectives: To show the demographics, type of treatment and clinical outcomes of patients with retroperitoneal tumors in Japan.

    Methods: We carried out a retrospective analysis of patients with retroperitoneal tumors treated between 2000 and 2012 at 12 university hospitals in Japan. Histology was re-evaluated using the 2013 World Health Organization classification. Read More

    Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
    Lancet Oncol 2017 Oct 4. Epub 2017 Oct 4.
    University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Patients with advanced sarcomas have a poor prognosis and few treatment options that improve overall survival. Chemotherapy and targeted therapies offer short-lived disease control. We assessed pembrolizumab, an anti-PD-1 antibody, for safety and activity in patients with advanced soft-tissue sarcoma or bone sarcoma. Read More

    Polypoid fibroadipose tumors of the esophagus: 'giant fibrovascular polyp' or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases.
    Mod Pathol 2017 Oct 6. Epub 2017 Oct 6.
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
    Giant fibrovascular polyp of the esophagus is a descriptive diagnostic term intended to encompass rare, large, polypoid esophageal masses composed of fibroadipose tissue. Despite sometimes dramatic clinical presentations, they have historically been considered to represent reactive, non-neoplastic proliferations. Recently, however, a small number of reports have described well-differentiated liposarcomas of the esophagus, mimicking giant fibrovascular polyps. Read More

    Leiomyosarcoma of maxilla: a case report with review of literature.
    J Exp Ther Oncol 2017 Sep;11(2):147-153
    Bhari Sharanesha S Manjunatha, Department of Oral Biology, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia.
    Objective: One challenging feature of head and neck pathology is that a dizzying array of spindle cell lesions occurs here which ranges all the way from reactive, very aggressive forms to malignant lesions. Leiomyosarcoma is one such malignant tumour of mesenchymal origin exhibiting smooth muscle differentiation; presenting generally nonspecific signs and symptoms. Here we present a case of leiomyosarcoma in a 21 year old female patient associated with single reddish pink swelling present in the posterior right maxillary tuberosity region with moderate facial asymmetry. Read More

    Pulmonary myelolipoma containing osseous tissue: An unexpected finding at autopsy.
    Respir Med Case Rep 2017 14;22:254-256. Epub 2017 Sep 14.
    Institute of Pathology, University of Zagreb, Šalata 10, Zagreb, Croatia.
    Pulmonary myelolipoma is a very rare benign tumor composed of mature adipose tissue and hematopoietic elements such as erythroid, myeloid and megakaryocytic. It usually represents accidental finding during autopsy or chest imaging, since most cases are asymptomatic. Larger masses can lead to hemorrhage, chest pain and chest organ compression. Read More

    Giant atypical lipoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):546-549
    Dermatology Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
    Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. Read More

    Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass.
    Int J Surg Pathol 2017 Sep 1:1066896917731517. Epub 2017 Sep 1.
    1 University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. Read More

    High-Dose Ifosfamide Chemotherapy in a Series of Patients Affected by Myxoid Liposarcoma.
    Sarcoma 2017 30;2017:3739159. Epub 2017 Aug 30.
    Medical Oncology Unit 2, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    Background: To report on the activity of high-dose prolonged-infusion ifosfamide (HDIFX) chemotherapy in a retrospective series of patients affected by myxoid liposarcoma treated at Fondazione IRCCS Istituto Nazionale dei Tumori in Milan, Italy.

    Patients And Methods: Patients with an advanced myxoid liposarcoma treated with HDIFX (14 g/sqm, i.v. Read More

    Outcome and Minimal Residual Disease Monitoring in Patients with t(16;21) Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
    Biol Blood Marrow Transplant 2017 Sep 20. Epub 2017 Sep 20.
    Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China. Electronic address:
    Patients with t(16;21) acute myelogenous leukemia (AML) who receive chemotherapy have poor outcomes. The treatment efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) must be identified, and the usefulness of minimal residual disease (MRD) monitoring requires evaluation. Fourteen consecutive patients with t(16;21) AML undergoing allo-HSCT at our institution were included in this study. Read More

    Primary Myxoid Liposarcoma of the Upper Thoracic Spine in an Elderly Patient.
    J Neurosci Rural Pract 2017 Aug;8(Suppl 1):S120-S122
    Department of Neurosurgery, Asclepeion General Hospital of Voula, Athens, Greece.
    Liposarcoma, one of the most common soft-tissue sarcomas, originates from primitive mesenchymal cells, and its diagnostic criteria have been well established. Myxoid liposarcoma is the second most common histological subtype, occurring more frequently during the fourth and fifth decades of life. There are only a few sporadic published cases of spinal liposarcomas, whatever primary or metastatic. Read More

    Surgical resection of a well-differentiated inflammatory liposarcoma of the middle mediastinum: a case report.
    J Thorac Dis 2017 Aug;9(8):E689-E693
    Department of Thoracic Oncology, Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan.
    Liposarcomas are the most common type of mesenchymal neoplasm in soft tissue sarcomas. Although they frequently develop at the lower limbs or retroperitoneum, cases arising from the mediastinum are rare. Furthermore, the incidence of the inflammatory subtype of well-differentiated liposarcoma is known to be low. Read More

    [Kombinovaná léčba měkkotkáňového sarkomu v oblasti pánve].
    Rozhl Chir 2017 ;96(6):263-266
    Soft tissue sarcomas (STS) constitute a heterogeneous group of rare malignant tumors of mesenchymal cell origin and they may develop in any part of the body. They can form enormous masses in certain localizations. A case report of a young woman with locally advanced liposarcoma in the pelvic cavity is presented. Read More

    Comparison of retroperitoneal liposarcoma extending into the inguinal canal and inguinoscrotal liposarcoma.
    Can J Surg 2017 Oct 1;60(6):5917. Epub 2017 Oct 1.
    From the Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (Rhu, Cho, Lee, H. Park, J. Park, Kim); and the Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (Choi).
    Background: This study was designed to analyze differences between retroperitoneal liposarcoma (RLPS) extending into the inguinal canal and inguinoscrotal liposarcoma.

    Methods: We retrospectively reviewed the records for patients who were managed for inguinal liposarcoma at Samsung Medical Center, a tertiary hospital, between January 1998 and December 2016. Patient data on demographics, tumour location, surgery, adjuvant therapy, histology, recurrence and death were collected. Read More

    Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard.
    Sci Rep 2017 Sep 19;7(1):11836. Epub 2017 Sep 19.
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Benefit from chemotherapy for well-differentiated/de-differentiated (WD/DD) liposarcomas has been reported to be minimal, however traditional response criteria may not adequately capture positive treatment effect. In this study, we evaluate benefit from first-line chemotherapy and characterize imaging response characteristics in patients with retroperitoneal (RP) WD/DD liposarcoma treated at The University of Texas MD Anderson Cancer Center. Response was assessed using RECIST (Response Evaluation Criteria in Solid Tumors) and an exploratory analysis of vascular response was characterized. Read More

    Establishing a patient-derived xenograft model of human myxoid and round-cell liposarcoma.
    Oncotarget 2017 Aug 21;8(33):54320-54330. Epub 2017 Apr 21.
    Departments of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
    Myxoid and round cell liposarcoma (MRCL) is a common type of soft tissue sarcoma. The lack of patient-derived tumor xenograft models that are highly consistent with human tumors has limited the drug experiments for this disease. Hence, we aimed to develop and validate a patient-derived tumor xenograft model of MRCL. Read More

    MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas.
    Oncotarget 2017 Aug 17;8(33):53968-53977. Epub 2017 Mar 17.
    Institut National de la Santé et de la Recherche Medicale, Institut Bergonié, Bordeaux, France.
    Background: Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) are characterized by a consistent amplification of the MDM2 gene. The PI3K/AKT/mTOR pathway has been suggested to play also an important role in their tumorigenesis. Our goal was to determine whether combined MDM2 and PI3K/AKT/mTOR targeting is associated with higher anti-tumor activity than single agent alone in preclinical models of WDLPS/DDLPS. Read More

    Propranolol 18F-FDG PET/CT: A Noninvasive Approach for Differential Diagnosis of Hibernoma and Liposarcoma.
    Clin Nucl Med 2017 Nov;42(11):879-880
    From the *Department of Nuclear Medicine, and †INSERM U1086 ANTICIPE, François Baclesse Cancer Centre; and ‡Department of Nuclear Medicine, University Hospital, Caen, France.
    A 76-year-old woman was referred for F-FDG PET/CT assessment of a colorectal cancer. A 9-cm F-FDG-avid fatty mass was depicted in the right thigh, suggesting either hibernoma or liposarcoma. Because MRI could not rule out well-differentiated liposarcoma, and biopsy was difficult, surveillance was decided. Read More

    Fine-needle aspiration of lipoblastoma: Cytological, molecular, and clinical features.
    Cancer 2017 Sep 13. Epub 2017 Sep 13.
    Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.
    Background: Lipoblastomas are rare, benign adipocytic tumors that present mostly during infancy. In about 70% of cases, these tumors carry abnormalities in chromosome 8, mainly leading to rearrangements of the PLAG1 gene.

    Methods: We report a series of histologically proven lipoblastomas with previous fine-needle aspiration (FNA) cytology from 9 patients (n = 10 samples) and describe their clinical, cytological, and molecular features. Read More

    Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.
    Am J Clin Pathol 2017 Aug;148(2):179-189
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
    Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics. Read More

    Identifying actionable variants using next generation sequencing in patients with a historical diagnosis of undifferentiated pleomorphic sarcoma.
    Int J Cancer 2018 Jan 9;142(1):57-65. Epub 2017 Oct 9.
    Sarcoma Program, Mount Sinai Hospital, Toronto, Canada.
    There are limited data regarding the molecular characterization of undifferentiated pleomorphic sarcomas (UPS; formerly malignant fibrous histiocytoma). This study aimed to investigate the utility of next generation sequencing (NGS) in UPS to identify subsets of patients who harbour actionable mutations. Patients diagnosed with UPS underwent pathological re-evaluation by a pathologist specializing in sarcoma. Read More

    Multiple skeletal muscle metastases revealing a cardiac intimal sarcoma.
    Skeletal Radiol 2017 Sep 8. Epub 2017 Sep 8.
    Department of Musculoskeletal Radiology, Clinique du Sport de Bordeaux-Mérignac, Mérignac, France.
    We report the case of a 59-year-old female with progressive bilateral painful swelling of the thighs. MRI revealed multiple intramuscular necrotic masses with similar morphologic patterns. Whole-body CT and 18-FDG PET-CT scans demonstrated additional hypermetabolic muscular masses and a lobulated lesion within the left atrial cavity. Read More

    miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells.
    Cancer Res 2017 Nov 7;77(21):5728-5740. Epub 2017 Sep 7.
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
    Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for approximately 13% of all soft tissue sarcoma in adults and cause substantial morbidity or mortality in the majority of patients. In this study, we evaluated the functions of miRNA (miR-193b) in liposarcoma in vitro and in vivo Deep RNA sequencing on 93 WDLS, 145 DDLS, and 12 normal fat samples demonstrated that miR-193b was significantly underexpressed in DDLS compared with normal fat. Reintroduction of miR-193b induced apoptosis in liposarcoma cells and promoted adipogenesis in human adipose-derived stem cells (ASC). Read More

    Dedifferentiated Liposarcoma in the Spermatic Cord Finally Diagnosed at 7th Resection of Recurrence: A Case Report and Bibliographic Consideration.
    Case Rep Oncol 2017 May-Aug;10(2):713-719. Epub 2017 Aug 9.
    Tohoku University Graduate School of Medicine, Sendai, Japan.
    Liposarcoma in the spermatic cord is infrequent, and accurate diagnosis of histopathological subtype is often difficult in spite of the importance of differential diagnosis for adequate treatment. A 54-year-old man underwent left-sided high orchiectomy with inguinal lymphadenectomy for a spermatic cord tumor in July 2006. The initial histopathological report diagnosed leiomyosarcoma in the spermatic cord. Read More

    Percutaneous Treatment of Superficial Femoral Artery Stenosis Secondary to Radiation Arteritis.
    Am Surg 2016 Nov;82(11):1098-1100
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee, USA.
    Radiation arteritis is a rare cause of lower extremity peripheral arterial occlusive disease, and has been traditionally treated with open interventions. There have been only a few reported cases of endovascular interventions for this disease. Previous reports described endovascular treatment in the iliac and common femoral regions, but intervention in the superficial femoral artery have not been described. Read More

    Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations.
    Acta Orthop Traumatol Turc 2017 Aug 28. Epub 2017 Aug 28.
    Istanbul University, Istanbul Medical Faculty, Department of Orthopedics and Traumatology, Turkey.
    Objective: The aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients.

    Methods: The study included 23 patients (16 men and 7 women with a mean age of 43 (24-69) years) with primary myxoid liposarcoma of the extremities, who were treated between January 1998 and December 2015. Inclusion criteria were histopathological confirmation of the diagnosis with both the initial biopsy and the resection specimen, and having undergone neoadjuvant radiotherapy. Read More

    Vertebroplasty and delayed subdural cauda equina hematoma: Review of literature and case report.
    World J Clin Cases 2017 Aug;5(8):333-339
    Maria Pia Tropeano, Biagia La Pira, Lorenzo Pescatori, Manolo Piccirilli, Department of Neurology and Psichiatry-Neurosurgery, Policlinico Umberto I - Sapienza, University of Rome, 00185 Rome, Italy.
    Vertebroplasy is considered an alternative and effective treatment of painful oncologic spine disease. Major complications are very rare, but with high morbidity and occur in less than 1% of patients who undergo vertebroplasty. Spinal subdural hematoma (SDH) is an extremely rare complication, usual developing within 12 h to 24 h after the procedure. Read More

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