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    1 OF 126

    Establishing a patient-derived xenograft model of human myxoid and round-cell liposarcoma.
    Oncotarget 2017 Aug 21;8(33):54320-54330. Epub 2017 Apr 21.
    Departments of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
    Myxoid and round cell liposarcoma (MRCL) is a common type of soft tissue sarcoma. The lack of patient-derived tumor xenograft models that are highly consistent with human tumors has limited the drug experiments for this disease. Hence, we aimed to develop and validate a patient-derived tumor xenograft model of MRCL. Read More

    MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas.
    Oncotarget 2017 Aug 17;8(33):53968-53977. Epub 2017 Mar 17.
    Institut National de la Santé et de la Recherche Medicale, Institut Bergonié, Bordeaux, France.
    Background: Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) are characterized by a consistent amplification of the MDM2 gene. The PI3K/AKT/mTOR pathway has been suggested to play also an important role in their tumorigenesis. Our goal was to determine whether combined MDM2 and PI3K/AKT/mTOR targeting is associated with higher anti-tumor activity than single agent alone in preclinical models of WDLPS/DDLPS. Read More

    Propranolol 18F-FDG PET/CT: A Noninvasive Approach for Differential Diagnosis of Hibernoma and Liposarcoma.
    Clin Nucl Med 2017 Sep 11. Epub 2017 Sep 11.
    From the *Department of Nuclear Medicine, and †INSERM U1086 ANTICIPE, François Baclesse Cancer Centre; and ‡Department of Nuclear Medicine, University Hospital, Caen, France.
    A 76-year-old woman was referred for F-FDG PET/CT assessment of a colorectal cancer. A 9-cm F-FDG-avid fatty mass was depicted in the right thigh, suggesting either hibernoma or liposarcoma. Because MRI could not rule out well-differentiated liposarcoma, and biopsy was difficult, surveillance was decided. Read More

    Fine-needle aspiration of lipoblastoma: Cytological, molecular, and clinical features.
    Cancer 2017 Sep 13. Epub 2017 Sep 13.
    Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.
    Background: Lipoblastomas are rare, benign adipocytic tumors that present mostly during infancy. In about 70% of cases, these tumors carry abnormalities in chromosome 8, mainly leading to rearrangements of the PLAG1 gene.

    Methods: We report a series of histologically proven lipoblastomas with previous fine-needle aspiration (FNA) cytology from 9 patients (n = 10 samples) and describe their clinical, cytological, and molecular features. Read More

    Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.
    Am J Clin Pathol 2017 Aug;148(2):179-189
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
    Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics. Read More

    Identifying actionable variants using next generation sequencing in patients with a historical diagnosis of undifferentiated pleomorphic sarcoma.
    Int J Cancer 2017 Sep 10. Epub 2017 Sep 10.
    Sarcoma Program, Mount Sinai Hospital, Toronto, Canada.
    There are limited data regarding the molecular characterization of undifferentiated pleomorphic sarcomas (UPS; formerly malignant fibrous histiocytoma). This study aimed to investigate the utility of next generation sequencing (NGS) in UPS to identify subsets of patients who harbour actionable mutations. Patients diagnosed with UPS underwent pathological re-evaluation by a pathologist specializing in sarcoma. Read More

    Multiple skeletal muscle metastases revealing a cardiac intimal sarcoma.
    Skeletal Radiol 2017 Sep 8. Epub 2017 Sep 8.
    Department of Musculoskeletal Radiology, Clinique du Sport de Bordeaux-Mérignac, Mérignac, France.
    We report the case of a 59-year-old female with progressive bilateral painful swelling of the thighs. MRI revealed multiple intramuscular necrotic masses with similar morphologic patterns. Whole-body CT and 18-FDG PET-CT scans demonstrated additional hypermetabolic muscular masses and a lobulated lesion within the left atrial cavity. Read More

    miR-193b-regulated signaling networks serve as tumor suppressors in liposarcoma and promote adipogenesis in adipose-derived stem cells.
    Cancer Res 2017 Sep 7. Epub 2017 Sep 7.
    Sarcoma Biology Laboratory, Sarcoma Disease Management Program, Department of Surgery, Memorial Sloan Kettering Cancer Center
    Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for approximately 13% of all soft tissue sarcoma in adults and cause substantial morbidity or mortality in the majority of patients. In this study, we evaluated the functions of miRNA (miR-193b) in liposarcoma in vitro and in vivo. Deep RNA sequencing on 93 WDLS, 145 DDLS and 12 normal fat samples demonstrated that miR-193b was significantly underexpressed in DDLS compared to normal fat. Read More

    Dedifferentiated Liposarcoma in the Spermatic Cord Finally Diagnosed at 7th Resection of Recurrence: A Case Report and Bibliographic Consideration.
    Case Rep Oncol 2017 May-Aug;10(2):713-719. Epub 2017 Aug 9.
    Tohoku University Graduate School of Medicine, Sendai, Japan.
    Liposarcoma in the spermatic cord is infrequent, and accurate diagnosis of histopathological subtype is often difficult in spite of the importance of differential diagnosis for adequate treatment. A 54-year-old man underwent left-sided high orchiectomy with inguinal lymphadenectomy for a spermatic cord tumor in July 2006. The initial histopathological report diagnosed leiomyosarcoma in the spermatic cord. Read More

    Percutaneous Treatment of Superficial Femoral Artery Stenosis Secondary to Radiation Arteritis.
    Am Surg 2016 Nov;82(11):1098-1100
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee, USA.
    Radiation arteritis is a rare cause of lower extremity peripheral arterial occlusive disease, and has been traditionally treated with open interventions. There have been only a few reported cases of endovascular interventions for this disease. Previous reports described endovascular treatment in the iliac and common femoral regions, but intervention in the superficial femoral artery have not been described. Read More

    Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations.
    Acta Orthop Traumatol Turc 2017 Aug 28. Epub 2017 Aug 28.
    Istanbul University, Istanbul Medical Faculty, Department of Orthopedics and Traumatology, Turkey.
    Objective: The aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients.

    Methods: The study included 23 patients (16 men and 7 women with a mean age of 43 (24-69) years) with primary myxoid liposarcoma of the extremities, who were treated between January 1998 and December 2015. Inclusion criteria were histopathological confirmation of the diagnosis with both the initial biopsy and the resection specimen, and having undergone neoadjuvant radiotherapy. Read More

    Vertebroplasty and delayed subdural cauda equina hematoma: Review of literature and case report.
    World J Clin Cases 2017 Aug;5(8):333-339
    Maria Pia Tropeano, Biagia La Pira, Lorenzo Pescatori, Manolo Piccirilli, Department of Neurology and Psichiatry-Neurosurgery, Policlinico Umberto I - Sapienza, University of Rome, 00185 Rome, Italy.
    Vertebroplasy is considered an alternative and effective treatment of painful oncologic spine disease. Major complications are very rare, but with high morbidity and occur in less than 1% of patients who undergo vertebroplasty. Spinal subdural hematoma (SDH) is an extremely rare complication, usual developing within 12 h to 24 h after the procedure. Read More

    Extensive left ventricular, pulmonary artery, and pericardial metastasis from myxoid liposarcoma 16 years after the initial detection of the primary tumour: a case report and review of the literature.
    Malays J Pathol 2017 Aug;39(2):201-205
    Tehran University of Medical Sciences, Department of Pathology, Shariati Hospital, Tehran, Iran.
    Liposarcoma is regarded as the second most common soft tissue malignant tumour. Metastasis of liposarcoma to the heart is very rare, and to date, less than 40 cases have been reported in the literature. We report a 46 year-old male with myxoid liposarcoma of the lower extremity who developed extensive metastasis to the left ventricle, pulmonary artery, and pericardium. Read More

    Cavin-2 is a specific marker for detection of well-differentiated liposarcoma.
    Biochem Biophys Res Commun 2017 Sep 1. Epub 2017 Sep 1.
    Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy. Electronic address:
    Caveolae are cholesterol enriched invaginations of the plasma membrane involved in a variety of processes, including glucose and fatty acids absorption, cell transduction and mechanoprotection. The biogenesis and function of caveolae depend on the activity of Caveolin (Cav-1, -2 and -3) and Cavin (Cavin-1, -2, -3 and -4) protein families. Since the membrane Cavin-2 protein was reported to play a key role in caveolae formation of adipocytes, in this work we have used a multidisciplinary approach to investigate its expression in liposarcoma (LPS), an adipocytic soft tissue sarcoma affecting adults. Read More

    Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report.
    Surg Case Rep 2017 Aug 30;3(1):96. Epub 2017 Aug 30.
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
    Background: Primary colonic and dedifferentiated liposarcomas are both remarkably rare. This work describes a case of primary colonic well-differentiated/dedifferentiated liposarcoma and reviews the clinical characteristics and current therapies for liposarcoma tumors.

    Case Presentation: A 52-year-old woman was referred to our hospital with a submucosal tumor of the ascending colon. Read More

    Activity of Eribulin in Patients With Advanced Liposarcoma Demonstrated in a Subgroup Analysis From a Randomized Phase III Study of Eribulin Versus Dacarbazine.
    J Clin Oncol 2017 Aug 30:JCO2016716605. Epub 2017 Aug 30.
    George D. Demetri, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; Patrick Schöffski, University Hospitals Leuven, Leuven, Belgium; Giovanni Grignani, Fondazione del Piemonte per l'Oncologia Istituto di Ricovero e Cura a Carattere Scientifico, Candiolo, Italy; Jean-Yves Blay, Université Claude Bernard and Centre Léon Bérard, Lyon, France; Robert G. Maki, Monter Cancer Center, Lake Success; and Cold Spring Harbor Laboratory, New Hyde Park, NY; Brian A. Van Tine, Barnes and Jewish Hospital, Washington University in St. Louis, St. Louis, MO; Thierry Alcindor, McGill University Health Centre, Montreal, Quebec, Canada; Robin L. Jones, The Royal Marsden Hospital, Institute of Cancer Research, London, United Kingdom; David R. D'Adamo and Matthew Guo, Eisai, Woodcliff Lake, NJ; and Sant Chawla, Sarcoma Oncology Center, Santa Monica, CA.
    Purpose A phase III study comparing eribulin with dacarbazine in patients with advanced liposarcoma (LPS) or leiomyosarcoma showed a significant improvement in overall survival (OS) for the eribulin arm, with a manageable toxicity profile. We now report the histology-specific subgroup analysis of the efficacy and safety of eribulin compared with dacarbazine in patients with LPS, an independently randomized stratified subgroup of this phase III trial. Methods Patients ≥ 18 years with advanced or metastatic dedifferentiated, myxoid/round cell, or pleomorphic LPS incurable by surgery or radiotherapy were included. Read More

    Pedunculated, well differentiated liposarcoma of the oesophagus mimicking giant fibrovascular polyp.
    Ann R Coll Surg Engl 2017 Sep;99(7):e209-e212
    University of Münster , Germany.
    We present a rare case of a big oesophageal liposarcoma causing dysphagia and weight loss in a 75-year-old patient. Endoscopically, a pedunculated lesion with subtotal obstruction of the oesophageal lumen had been detected and thoracoabdominal oesophageal resection with gastric sleeve reconstruction was performed. Surprisingly, a liposarcoma of the oesophagus was revealed on histopathological analysis, showing MDM2 overexpression. Read More

    Aldoxorubicin for the treatment of soft tissue sarcoma.
    Expert Opin Investig Drugs 2017 Oct 28;26(10):1175-1179. Epub 2017 Aug 28.
    a Cedars-Sinai Medical Center , Samuel Oschin Comprehensive Cancer Institute, Medicine , Los Angeles , CA , USA.
    Intoduction: Soft tissue sarcomas (STS) encompass a group of rare tumors arising from mesenchymal tissue. Traditionally, anthracycline-based chemotherapy, with doxorubicin, is the main treatment for advanced STS. Areas covered: Aldoxorubicin is a doxorubicin derivative containing a carboxylic hydrazone and serves as a prodrug of doxorubicin. Read More

    Results of a prospective phase 2 study of pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
    Cancer 2017 Aug 18. Epub 2017 Aug 18.
    Vector Oncology, Memphis, Tennessee.
    Background: This phase 2, single-arm, multicenter study was designed to determine the treatment activity and safety of single-agent pazopanib in patients with unresectable or metastatic liposarcoma.

    Methods: Eligible patients had high-grade or intermediate-grade liposarcoma with measurable tumors that were unresectable or metastatic, documented disease progression, and had received any number of prior treatments, excluding previous treatment with a vascular endothelial growth factor inhibitor or a tyrosine kinase inhibitor. Patients received oral pazopanib 800 mg once daily for 28-day cycles. Read More

    Programmed Death Ligand 1 (PD-L1) Expression in Malignant Mesenchymal Tumors.
    Turk Patoloji Derg 2017 ;1(1):192-197
    Department of Pathology, Research and Application Center, Hacettepe University, Faculty of Medicine, ANKARA, TURKEY.
    Objective: Programmed death ligand 1 (PD-L1) found on tumor cells has recently been reported to have a key role in the development and dissemination of many tumors, such as lung and breast carcinomas. In this study, we retrospectively analyzed PD-L1 expression among different types of sarcomas.

    Material And Method: Tissue microarrays of 3-4 mm diameter were composed from paraffin blocks of 222 various sarcomas. Read More

    Myxoid Liposarcoma Originating In The Anterior Mediastinum.
    J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):818-820
    Department of Cardiothoracic Surgery, Aga Khan University, Karachi, Pakistan.
    Myxoid liposarcomas of the head and neck are mostly metastatic in nature, with the primary lesion usually in lower extremities or retroperitoneum. Primary mediastinal liposarcomas are even rarer. Although there have been previous cases reporting their incidence, there is no evidence of any case comprising of both the neck and the mediastinal region yet. Read More

    [Metastatic paratesticular liposarcoma].
    Pan Afr Med J 2017 8;27:101. Epub 2017 Jun 8.
    Service d'Urologie A, Hôpital Ibn Sina, CHU Rabat, Maroc.
    We report the dramatic case of a 18-year old patient with immediately metastatic round cells paratesticular liposarcoma. It is a rare tumor that develops in the fatty tissue surrounding the testicle and the spermatic cord. Clinical and radiological signs are nonspecific and diagnosis is usually based on surgical specimen examination. Read More

    Effective apatinib treatment of pleomorphic liposarcoma: A case report.
    Medicine (Baltimore) 2017 Aug;96(33):e7771
    Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
    Rationale: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease.

    Patient Concerns: We presented an 81-year-old Chinese woman with advanced PLS who received apatinib after failure chemotherapy.

    Diagnoses: The patient was diagnosed as having PLS by biopsy. Read More

    Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening.
    Medicine (Baltimore) 2017 Aug;96(33):e7537
    aDepartment of Surgery bDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    This study sought to identify factors related to the prognosis of intra-abdominal liposarcoma and to determine the optimal minimum duration for remnant tumor screening. Intra-abdominal liposarcoma is associated with high rates of incomplete resection and recurrence requiring a sophisticated follow-up strategy.Patients who underwent surgery for intra-abdominal liposarcoma were included. Read More

    Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens.
    Vet Pathol 2017 Jan 1:300985817723691. Epub 2017 Jan 1.
    1 Department of Pathology, Microbiology, Immunology, University of California-Davis, Davis, CA, USA.
    Liposarcoma, rhabdomyosarcoma, and hibernoma share some overlapping histologic and immunohistochemical features. Although immunohistochemistry (IHC) is commonly used in the diagnosis of these neoplasms, expression of muscle markers has been reported in human liposarcoma and canine hibernoma in addition to rhabdomyosarcoma. Thus, these neoplasms are a diagnostic challenge but important to distinguish because of differences in prognosis and treatment. Read More

    Radical Nephrectomy for Primary Retroperitoneal Liposarcoma Near the Kidney has a Beneficial Effect on Disease-Free Survival.
    World J Surg 2017 Aug 14. Epub 2017 Aug 14.
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Korea.
    Background: The purpose of this study is to analyze the clinical impact of radical nephrectomy on retroperitoneal liposarcoma near the kidney.

    Methods: Data of patients who underwent surgery for unilateral primary retroperitoneal liposarcoma near the kidney were retrospectively collected. Patients were divided into four groups according to whether they underwent nephrectomy and combined resection of other organs. Read More

    Preoperative Factors Associated with Infiltrative Histologic Growth Patterns in Extremity Soft Tissue Sarcoma.
    Sarcoma 2017 20;2017:5419394. Epub 2017 Jul 20.
    Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
    Soft tissue sarcoma (STS) with an infiltrative histologic growth pattern, when compared to STS with an expansile pattern, may pose difficulties in local control. Preoperative assessment of the presence of infiltrative histologic growth pattern would be helpful in deciding treatment strategies. A review of 144 patients who underwent surgery for extremity STS was performed. Read More

    Retroperitoneal extrarenal angiomyolipoma at the surgical bed 8 years after a renal angiomyolipoma nephrectomy: A case report and review of literature.
    Urol Ann 2017 Jul-Sep;9(3):288-292
    Department of Radiology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
    Retroperitoneal extrarenal angiomyolipoma (RERAML) are rare and close mimickers of retroperitoneal liposarcoma on both imaging and histopathology. However, imaging findings including heterogeneity, hyperdensity on unenhanced computed tomography, intralesional hemorrhage, absence of calcifications, low signal intensity on T2-weighted magnetic resonance imaging, and dilated intratumoral vessels can lead to the diagnosis of RERAML. Diagnosis of RERAML can avoid unnecessary surgery since conservative medical management with continued surveillance has been proven to be effective for RERAML whereas surgical resection is the treatment for liposarcoma. Read More

    Well-differentiated inflammatory liposarcoma with metastasis in a 6-y-old cat.
    J Vet Diagn Invest 2017 Aug 1:1040638717725349. Epub 2017 Aug 1.
    Departments of Veterinary Clinical Sciences (Alvarez, Shaffer) School of Veterinary Medicine, University of Wisconsin, Madison, WI.
    Liposarcomas are rare malignant tumors showing adipocytic differentiation. We report a well-differentiated liposarcoma in a 6-y-old, male neutered cat with a prominent inflammatory component and metastatic spread to the lungs. The patient was initially presented because of fever, lethargy, and a firm subcutaneous inguinal mass. Read More

    A novel protein expression signature differentiates benign lipomas from well-differentiated liposarcomas.
    Mol Clin Oncol 2017 Sep 13;7(3):315-321. Epub 2017 Jul 13.
    Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.
    Benign lipomas and well-differentiated liposarcomas share many histological and molecular features. Due to their similarities, patients with these lipomatous tumors are misdiagnosed up to 40% of the time following radiological detection, up to 17% of the time following histological examination, and in as many as 15% of cases following fluorescent in situ hybridization for chromosomal anomalies. Incorrect classification of these two tumor types leads to increased costs to the patient and delayed accurate diagnoses. Read More

    FDA Approval Summary: Trabectedin for Unresectable or Metastatic Liposarcoma or Leiomyosarcoma Following an Anthracycline-Containing Regimen.
    Clin Cancer Res 2017 Aug 3. Epub 2017 Aug 3.
    Office of Oncology Drug Products, U.S. Food and Drug Administration.
    On October 23, 2015, the U.S. Food and Drug Administration approved trabectedin, a new molecular entity for the treatment of patients with unresectable or metastatic liposarcoma or leiomyosarcoma who received a prior anthracycline-containing regimen. Read More

    Importance of preoperative diagnosis for management of patients with suspected retroperitoneal sarcoma.
    ANZ J Surg 2017 Aug 2. Epub 2017 Aug 2.
    Sarcoma Service and Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    Soft tissue sarcoma is an umbrella term which encompasses over 60 histological tumour types. Approximately 15% of soft tissue sarcomas arise in the retroperitoneum. This complex group of tumours poses unique management challenges due to their often large size, histological heterogeneity and complexity of anatomical relationships. Read More

    Atypical Imaging Features of a Simple Intramuscular Lipoma.
    J Clin Diagn Res 2017 Jun 1;11(6):TD01-TD02. Epub 2017 Jun 1.
    Assistant Professor, Department of Radiodiagnosis, Indira Gandhi Medical College and Research Institute, Puducherry, India.
    Lipoma is a benign tumour of mesenchymal tissue which closely resembles normal fat even histologically but for its biochemical and ultrastructural differences. Simple lipoma presents as a mass which resembles fat on all the imaging modalities. Atypical lipoma, lipoma variants and liposarcoma show specific imaging features. Read More

    Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus.
    Clin Sci (Lond) 2017 Aug 31;131(16):2161-2182. Epub 2017 Jul 31.
    The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, U.K, Developmental Biology Division.
    The proliferation, differentiation, and survival of cells of the macrophage lineage depends upon signals from the macrophage colony-stimulating factor (CSF) receptor (CSF1R). CSF1R is expressed by embryonic macrophages and induced early in adult hematopoiesis, upon commitment of multipotent progenitors to the myeloid lineage. Transcriptional activation of CSF1R requires interaction between members of the E26 transformation-specific family of transcription factors (Ets) (notably PU. Read More

    Well-differentiated, pedunculated liposarcoma of the hypopharynx.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Jul 28. Epub 2017 Jul 28.
    Service d'ORL et de chirurgie cervico-faciale, HUS, hôpital de Hautepierre, avenue Molière, 67000 Strasbourg, France.
    Introduction: Liposarcoma of the hypopharynx is extremely rare, as only 28 cases have been reported in the literature. The cardinal symptom of liposarcoma is progressively worsening dysphagia.

    Case Report: The authors report the case of a 71-year-old man who presented with dysphagia, marked weight loss over several weeks and an episode of exteriorization of a solid mass from the mouth during an episode of vomiting. Read More

    Therapeutic strategies for locally recurrent and metastatic de-differentiated liposarcoma with herpes simplex virus-thymidine kinase-expressing mesenchymal stromal cells.
    Cytotherapy 2017 Sep 29;19(9):1035-1047. Epub 2017 Jul 29.
    Transplantation Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea; Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, Republic of Korea; Department of Surgery, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:
    Background Aims: Major challenges in de-differentiated liposarcoma (DDLPS) therapy are the high rate of sequential recurrence (>80%) and metastasis (20-30%) following surgical removal. However, well-defined therapeutic strategies for this rare malignancy are lacking and are critically needed.

    Methods: We investigated a new approach to DDLPS therapy with mesenchymal stromal cells expressing herpes simplex virus-thymidine kinase (MSC-TK). Read More

    Soft tissue sarcomas: From a morphological to a molecular biological approach.
    Pathol Int 2017 Sep 31;67(9):435-446. Epub 2017 Jul 31.
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
    Recently developed molecular genetic techniques have led to the elucidation of tumor-specific genomic alterations and thereby the reclassification of tumor entities of soft tissue sarcoma. A solitary fibrous tumor-mimicking tumor with the AHRR-NCOA2 gene has been isolated as angiofibroma of soft tissue. As for small round cell sarcomas, novel fusion genes such as CIC-DUX4 and BCOR-CCNB3 have been identified in these tumor groups. Read More

    Clinicopathological characteristics and experience in the treatment of giant retroperitoneal liposarcoma: A case report and review of the literature.
    Cancer Biol Ther 2017 Jul 31:1-6. Epub 2017 Jul 31.
    a Department of Gastrointestinal Surgery , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
    Retroperitoneal liposarcoma (RPLS) is a rare tumor, especailly those over 20 kg that are called "giant liposarcoma," whose characteristics and treatments remain relatively unknown. Herein, we report a giant RPLS measuring 65 × 45 × 30 cm in diameter and 31 kg in weight, which we successfully performed complete excision through interdisciplinary cooperation. The patient had an uneventful postoperative course and was discharged without complications. Read More

    MDM4 amplification in a case of dedifferentiated liposarcoma and in silico data supporting an oncogenic event alternative to MDM2 amplification in a subset of cases.
    Histopathology 2017 Jul 30. Epub 2017 Jul 30.
    Centre Léon Bérard, Department of Biopathology, Lyon, France.
    Well differentiated and dedifferentiated liposarcomas (WD/DDLPS) are underlined by 12q13-q14 amplifications encompassing MDM2, considered as the core oncogene driving their pathogenesis through TP53 inactivation(1, 2) . Their progression involves the inactivation of the RB1 pathway through CDKN2A-CCND1-CDK4 alterations(3) . According to the French sarcoma database RRePS, 1% of cases suspicious for WD/DDLPS fail to prove MDM2 amplification, therefore suggesting that alternative oncogenic pathways might replace MDM2 amplification. Read More

    Needle tract seeding following core biopsies in retroperitoneal sarcoma.
    Eur J Surg Oncol 2017 Sep 24;43(9):1740-1745. Epub 2017 Jun 24.
    Sarcoma Unit, Department of Surgery, The Royal Marsden Hospital, London, UK.
    Background: Retroperitoneal tumours often require a preoperative core needle biopsy to establish a histological diagnosis. Literature is scarce regarding the risk of biopsies in retroperitoneal sarcomas, so the aim of this study is to identify the potential risks of core needle biopsies causing needle tract recurrences or local recurrences.

    Method: Patients who underwent resection of a primary retroperitoneal sarcoma between 1990 and 2014 were identified from a prospectively maintained database from two tertiary referral centres. Read More

    PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall.
    Appl Immunohistochem Mol Morphol 2017 Jul 26. Epub 2017 Jul 26.
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL.
    PAX8 is used as a diagnostic aid in classifying retroperitoneal (RP) spindle cell tumors. PAX8 positivity in a spindled RP tumor is typically associated with sarcomatoid renal cell carcinoma (SRCC). However, PAX8 expression in solitary fibrous tumor (SFT), a tumor not uncommon to the RP, has not been extensively studied. Read More

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