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    Magnetic resonance imaging findings for differential diagnosis of perianal plexiform schwannoma: Case report and review of the literature.
    World J Clin Cases 2018 May;6(5):88-93
    Department of Colorectal Surgery, the Suzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Suzhou 215000, Jiangsu Province, China.
    Plexiform schwannoma is an extremely rare variant of schwannoma, accounting for approximately 5% of cases. Due to the rarity and lack of typical symptoms, signs and radiological images, a definite diagnosis of plexiform schwannoma may not be made by clinicians prior to biopsy. In the present study, we report the first case (to our knowledge) of perianal plexiform schwannoma arising from the overlapped skin of the ischioanal fossa, and we propose an intratumorally nonenhanced circumferential capsule dividing the tumour into multiple homogeneously enhanced nodules as a magnetic resonance imaging feature to aid in the differential diagnosis of plexiform schwannoma from ancient schwannoma, cavernous haemangioma, liposarcoma and plexiform neurofibroma. Read More

    [A Case of Retroperitoneal Liposarcoma in which Magnetic Resonance Imaging was Useful in the Decision of Resection of Primary and RecurrentTumors].
    Hinyokika Kiyo 2018 Apr;64(4):145-149
    The Department of Urology, Osaka International Cancer Institute.
    A 47-year-old female was referred to our hospital because of retroperitoneal tumor which was detected by computer tomography (CT). Since the tumor was considered to be benign by magnetic resonance imaging (MRI), she was followed by MRI every 3 months. The site of the tumor was gradually increased, and 15 months after presentation, a lesion with high signal intensity on diffusion weighted image (DWI) appeared in the tumor. Read More

    Options for treating different soft tissue sarcoma subtypes.
    Future Oncol 2018 May;14(10s):25-49
    Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University of Duisburg-Essen, Essen, Germany.
    Management of soft tissue sarcoma is increasingly subtype-dependent. Surgery is recommended for uterine leiomyosarcoma, with trabectedin being the preferred option for advanced disease when the treatment goal is long-term tumor stabilization. Liposarcoma subgroups are characterized by distinctive morphologies and genetics, different patterns of disease progression and clinical behavior, and variable responses to treatment. Read More

    Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma.
    Cancer Sci 2018 May 14. Epub 2018 May 14.
    Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
    Glioblastoma is the most common and devastating type of malignant brain tumor. We recently found that eribulin suppresses glioma growth in vitro and in vivo and that eribulin is efficiently transferred into mouse brain tumors at a high concentration. Eribulin is a non-taxane microtubule inhibitor approved for breast cancer and liposarcoma. Read More

    Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat.
    J Toxicol Pathol 2018 Apr 6;31(2):141-146. Epub 2018 Jan 6.
    Department of Human Pathology, School of Medicine, Juntendo University, 1-1-19 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
    Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there was a large amount of fatty tissue covering the mesentery, pancreas, and retroperitoneum; a white nodule in the right kidney; and paleness of the liver. Read More

    Lipomas of the Oral Cavity: Utility of MDM2 and CDK4 in Avoiding Overdiagnosis as Atypical Lipomatous Tumor.
    Head Neck Pathol 2018 May 10. Epub 2018 May 10.
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
    Traumatized lipomas with degenerative change may demonstrate histopathologic features that mimic atypical lipomatous tumor (ALT). Previously reported series of ALT involving the oral cavity preceded routine use of MDM2 and CDK4 immunohistochemistry. Our aim is to evaluate MDM2 and CDK4 immunohistochemical expression in adipocytic tumors arising in this site, in conjunction with the histiocytic marker PU. Read More

    Treatment patterns and survival among older adults in the United States with advanced soft-tissue sarcomas.
    Clin Sarcoma Res 2018 3;8. Epub 2018 May 3.
    4RTI Health Solutions, 307 Waverley Oaks Road, Suite 101, Waltham, MA 02452 USA.
    Background: To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histologic subtypes.

    Methods: We conducted a retrospective cohort analysis using the SEER. The study population comprised patients ≥ 65 years old with advanced STS (excluding osteosarcoma, Kaposi sarcoma, and gastrointestinal stromal tumors) diagnosed from January 1, 2001 to December 31, 2011. Read More

    Dedifferentiated liposarcoma of the oral floor: A case study and literature review of 50 cases of head and neck neoplasm.
    Oncol Lett 2018 May 15;15(5):7681-7688. Epub 2018 Mar 15.
    Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan.
    Dedifferentiated liposarcoma (DDLS) has a relatively poor prognosis, however this neoplasm rarely occurs in the head and neck. To date, no definite protocol has been established for the diagnosis and treatment of head and neck DDLS. The present study reports the case of a 69-year-old male patient with DDLS of the oral floor. Read More

    Pancreatic Lipomatous Hamartoma: A Hitherto Unrecognized Variant.
    Am J Surg Pathol 2018 May 4. Epub 2018 May 4.
    Departments of Pathology.
    Pancreatic masses consisting of lipomatous components clinically include lipoma, liposarcoma, lipomatous pseudohypertrophy of the pancreas, fat-containing neoplasms such as perivascular epithelioid cell tumor, and malignant neoplasm with lipoid degeneration. We present pancreatic lipomatous hamartoma, which has not been reported hitherto. A solid pancreatic mass was detected from a computed tomographic scan check-up in each of 3 cases of Japanese men. Read More

    [Epididymal liposarcoma with metastases to the retroperitoneal space and peritoneal cavity: A case report and literature review].
    Zhonghua Nan Ke Xue 2017 Dec;23(12):1103-1106
    Department of Urology, Shanghai General Hospital / Shanghai Yiyuan School of Clinical Medicine, Nanjing Medical University, Shanghai 200080, China.
    Objective: To report a rare case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity for the purpose of improving the diagnosis and treatment of the disease.

    Methods: We retrospectively analyzed the clinical data about a case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity, reviewed relevant literature at home and abroad, and investigated the presentation, diagnosis and treatment of the disease.

    Results: A 47-year-old male patient with epididymal liposarcoma underwent radical left orchiectomy with high ligation of the spermmatic cord. Read More

    Para-anal lipoma as a rare consequence to perineal trauma. Case-report and review of the literature.
    Acta Chir Belg 2018 May 7:1-6. Epub 2018 May 7.
    a Colorectal Surgery Unit, Department of Abdominal Surgery and Transplantation , Cliniques universitaires Saint-Luc, Université Catholique de Louvain , Brussels , Belgium.
    Introduction: Lipomas are the most common benign mesenchymal tumors which can be found in any part of the body. Nevertheless, their etiology and pathogenesis remain unknown. It is hypothesized that some of these lesions could result from an acute or chronic trauma. Read More

    Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB.
    Oncotarget 2018 Apr 13;9(28):19929-19944. Epub 2018 Apr 13.
    Istituto per l'Endocrinologia e l'Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy.
    Therapy-induced senescence is a major cellular response to chemotherapy in solid tumors. Senescent tumor cells acquire a secretory phenotype, or SASP, and produce pro-inflammatory factors, whose expression is largely under NF-κB transcriptional control. Secreted factors play a positive role in driving antitumor immunity, but also exert negative influences on the microenvironment, and promote tumor growth and metastasis. Read More

    Targeted next generation sequencing of well-differentiated/dedifferentiated liposarcoma reveals novel gene amplifications and mutations.
    Oncotarget 2018 Apr 13;9(28):19891-19899. Epub 2018 Apr 13.
    Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA.
    Well-differentiated/dedifferentiated liposarcoma is a common soft tissue sarcoma with approximately 1500 new cases per year. Surgery is the mainstay of treatment but recurrences are frequent and systemic options are limited. 'Tumor genotyping' is becoming more common in clinical practice as it offers the hope of personalized targeted therapy. Read More

    Semi-Automated Segmentation of the Tumor Vasculature in Contrast-Enhanced Ultrasound Data.
    Ultrasound Med Biol 2018 May 2. Epub 2018 May 2.
    Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic and Helmholtz Institute for Biomedical Engineering, Aachen, Germany. Electronic address:
    The vascular architecture in tumors contains relevant information for tumor classification and evaluation of therapy responses. To develop a reliable and user-independent analysis tool, a foreground detection algorithm was combined with a maximum-intensity projection to obtain a high signal-to-noise image from contrast-enhanced B-mode data sets, enabling vessel segmentation by thresholding. Parameters describing the density of the vascular network, the number of vessels and the number of branches were extracted. Read More

    Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas.
    Oncol Lett 2018 May 22;15(5):7489-7496. Epub 2018 Mar 22.
    Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
    Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene. Read More

    The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center.
    J Surg Oncol 2018 May 3. Epub 2018 May 3.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: The pathogenesis of well differentiated liposarcoma (WDLPS) is poorly understood and pathologic characterization is often challenging. Descriptive terms (such as sclerosing, myxoid, inflammatory, spindle cell) are frequently encountered in the pathology reports and are of unknown clinical significance.

    Methods: Sixty-two patients with primary retroperitoneal WDLPS resected at our institution were identified (1996-2011). Read More

    The added value of chemical shift MRI in the preoperative diagnosis of thymolipoma.
    Tumori 2018 Mar 1:300891618763204. Epub 2018 Mar 1.
    Institute of Radiology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
    Thymolipoma is a rare tumor of the thymus. Classic radiologic findings of thymolipoma include fatty masses of the anterior mediastinum in conjunction with the thymus. Differential diagnosis with other more aggressive entities like liposarcoma and teratoma can be challenging. Read More

    Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
    Cancer Treat Rev 2018 Apr 22;66:74-81. Epub 2018 Apr 22.
    Division of Orthopedic Surgery, The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada. Electronic address:
    Background: The molecular pathogenesis of many forms of soft tissue sarcomas (STS) have been rigorously characterized in the medical literature, which may be particularly important for the diagnosis and prediction of prognosis in STS.

    Methods: Electronic databases (2005 to October 2016) were searched. Gastrointestinal stromal tumor and pediatric sarcomas were excluded. Read More

    Whole blood miRNA expression analysis reveals miR-3613-3p as a potential biomarker for dedifferentiated liposarcoma.
    Cancer Biomark 2018 Apr 9. Epub 2018 Apr 9.
    Clinic for Plastic and Hand Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Background: Liposarcoma constitute about 13% of all soft tissue sarcoma and are associated with a high risk of metastases. As the preoperative differentiation between benign and malign lipomatous tumors is restricted to magnetic resonance imaging, computed tomography and biopsy, we performed a miRNA array to distinguish dedifferentiated liposarcoma patients from healthy controls and lipoma patients.

    Methods: Blood samples of patients with dedifferentiated liposarcoma, healthy controls and lipoma patients were collected. Read More

    Homogeneous myxoid liposarcomas mimicking cysts on MRI: A challenging diagnosis.
    Eur J Radiol 2018 May 5;102:41-48. Epub 2018 Mar 5.
    Department of Radiology, Institut Bergonié, 221 cours de l'Argonne, 33076, Bordeaux, France.
    Objectives: Myxoid liposarcoma (M-LPS) is the second most frequent subtype of liposarcoma. Foci of fat on MRI are strongly suggestive of this diagnosis. The aims of this study are to (i) assess the prevalence of perfectly homogeneous M-LPS-mimicking cyst and characterize their associated clinical and pathological features and to (ii) identify helpful clues to prevent misdiagnosis when encountered with a cyst-like lesion in soft tissue parts. Read More

    Submandibular lipoblastoma: Case report of a rare tumor in childhood.
    Avicenna J Med 2018 Apr-Jun;8(2):55-57
    Department of Pathology, Salah Azaiez Institute, Tunis 1006, Tunisia.
    Lipoblastoma is a rare, benign tumor usually occurring in childhood. It is essentially localized in the extremities and trunk, with few cases reported in the neck. We report the case of a 2-year-old girl with a rapidly enlarging, painless neck mass. Read More

    Differences in recurrence and survival of extremity liposarcoma subtypes.
    Eur J Surg Oncol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Surgical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075, EA Rotterdam, The Netherlands. Electronic address:
    Background: Liposarcomas can be divided into four subtypes and are most frequently located in the extremities. There are currently no studies comparing the clinical outcomes, such as local recurrence and distant metastasis, between the distinct subtypes of primary LPS of the extremity specifically.

    Methods: Retrospective databases of two expertise centres (Rotterdam-R, Warsaw-W) of patients with liposarcoma located in the extremities from 1985 to 2015 were used to analyse 5-year local recurrence-free survival (5y-LRFS), 5-year distant metastasis-free survival (5y-DMFS) and 5-year overall survival (5y-OS). Read More

    Successful resection of a giant thoracic myxoid liposarcoma.
    Asian Cardiovasc Thorac Ann 2018 Jan 1:218492318772763. Epub 2018 Jan 1.
    4 Department of Cardiothoracic Surgery, Sarawak General Hospital Heart Centre, Kota Samarahan, Sarawak, Malaysia.
    Primary liposarcoma is an extremely rare disease. We report a case of giant thoracic myxoid liposarcoma that occupied the whole left hemithorax and was successfully resected. We discuss the surgical considerations and difficulties encountered, and how we overcome these challenges. Read More

    Imaging appearance of well-differentiated liposarcomas with myxoid stroma.
    Skeletal Radiol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Radiology, University of Michigan Hospitals, Taubman Center 2910F, SPC 5326, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5326, USA.
    Objective: Describe the imaging appearance of well-differentiated liposarcoma with myxoid stroma (WDLMS) and correlate with histopathology.

    Materials And Methods: A keyword search of the institution medical records was performed from 1 January 2000 to 30 June 2017. The histopathology slides of cases identified in this fashion were then reviewed by a pathologist. Read More

    Academic Facility Utilization and Survival Outcomes in Adult Head and Neck Sarcomas: An NCDB Analysis.
    Otolaryngol Head Neck Surg 2018 Apr 1:194599818768495. Epub 2018 Apr 1.
    1 Division of Otolaryngology Head and Neck Surgery, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
    Objectives To investigate clinicopathologic and treatment factors associated with survival in adult head and neck sarcomas in the National Cancer Database (NCDB). To analyze whether treatment settings and therapies received influence survival outcomes and to compare trends in utilization via an aggregated national data set. Study Design Prospectively gathered data. Read More

    Preoperative evaluation of the efficacy of radio-hyperthermo-chemotherapy for soft tissue sarcoma in a case series.
    PLoS One 2018 16;13(4):e0195289. Epub 2018 Apr 16.
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
    Purpose: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor. Read More

    Liposarcoma Preoperatively Diagnosed as Lipoma: 10-Year Experience at a Single Institution.
    Dermatol Surg 2018 Apr 13. Epub 2018 Apr 13.
    Department of Plastic Surgery, Kyorin University School of Medicine, Tokyo, Japan.
    Background: On rare occasions, a lesion preoperatively diagnosed as a lipoma is ultimately diagnosed as a liposarcoma. It is important to differentiate liposarcomas from lipomas preoperatively.

    Objective: To examine characteristic features of liposarcomas preoperatively diagnosed as lipomas. Read More

    Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system.
    Biosci Trends 2018 May 15;12(2):185-192. Epub 2018 Apr 15.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of HepatoPancreato-Biliary Surgery, Peking University Cancer Hospital and Institute.
    This study sought to evaluate the infiltration tendency of retroperitoneal liposarcoma (RPLS) from a new pathological angle by exploring the infiltration characteristics, which could provide helpful information to facilitate surgical decision-making and prognosis prediction. Concurrently, we aim to identify significant indicators of infiltration. A total of 61 consecutive patients with RPLS at our institution were retrospectively analyzed. Read More

    Giant Mediastinal Liposarcoma: A Rare Yet Distinct Clinical Entity.
    Ann Thorac Surg 2018 Apr 11. Epub 2018 Apr 11.
    Division of General Thoracic Surgery, Michael E. DeBakey Department of Surgery. Electronic address:
    Mediastinal liposarcomas are rare tumors that occasionally present as unusually large and rapidly growing mediastinal masses resulting in compressive symptoms. We present a case of a 48-year old female undergoing resection of a mediastinal liposarcoma of massive proportion, and propose that "giant mediastinal liposarcomas" be identified as a distint clinical entity. Read More

    Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma.
    Int J Urol 2018 Apr 12. Epub 2018 Apr 12.
    Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
    Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Read More

    [Giant Retroperitoneal Liposarcoma Treated by Surgical Resection and Chemotherapy - A Case Report].
    Gan To Kagaku Ryoho 2018 Mar;45(3):548-550
    Dept. of Surgery, Saiseikai Yahata General Hospital.
    As the treatment for the liposarcoma, there is no effective chemotherapy and a surgical remedy is required. We present the case of a 64-year-old man who complained about difficulty in swallowing and discomfort of throat. Computed tomography revealed a large enhancing left sided retroperitoneal mass invading the retroperitoneal space and it was displaced to the right. Read More

    A case report of symptomatic presacral myelolipoma.
    Medicine (Baltimore) 2018 Apr;97(15):e0337
    Division of Gastroenterology and Hepatology, MedStar Georgetown University Hospital.
    Rationale: Extra-adrenal myelolipoma in the presacral area often raises a concern for liposarcoma because they have similar radiologic features.

    Patient Concerns: A 70-year-old woman with multiple abdominal surgeries in the past presented with persistent lower abdominal pain and anemia. A presacral mass, found on a pelvic magnetic resonance image (MRI), was suspicious of liposarcoma, as it is the most common fat containing mass in the presacral area. Read More

    Uncommon presentation, rare complication and previously undescribed oncologic association of pheochromocytoma; the great masquerader.
    BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.
    Division of Cardiology, Department of Medicine, Johns Hopkins Hospital and Health System, Baltimore, Maryland, USA.
    We describe the case of a 67-year-old man presenting with ventricular tachycardia (VT) and systolic heart failure secondary to a left adrenal phaeochromocytoma. After treatment with amiodarone, the patient's VT resolved. However, his course was complicated by femoral deep venous thrombosis secondary to an incidentally discovered dedifferentiated liposarcoma of the thigh, for which he was prescribed a course of enoxaparin. Read More

    Liposarcoma in a Backyard Silkie and Retrospective Summary of Neoplasms Diagnosed in Backyard Chickens Submitted to the California Animal Health and Food Safety Laboratory System, 2008-2017.
    Avian Dis 2018 Mar;62(1):124-129
    California Animal Health & Food Safety Laboratory System, University of California, Davis, Turlock Branch, 1550 North Soderquist Road, Turlock, CA 95381.
    Liposarcomas are a malignant neoplasm of adipocytes, and are rarely diagnosed in avian species. This case report describes the evidence supporting a diagnosis of metastatic liposarcoma in a backyard silkie chicken. On September 28, 2017, a dead 3-yr-old backyard silkie chicken, with a history of unknown skin lesions involving the entire body and severe weight loss, was submitted to California Animal Health and Food Safety Laboratory System-Turlock branch for necropsy. Read More

    Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer.
    Genome Res 2018 May 4;28(5):726-738. Epub 2018 Apr 4.
    Genomics and Epigenetics Division, Garvan Institute of Medical Research, New South Wales 2010, Australia.
    Genomic rearrangements are common in cancer, with demonstrated links to disease progression and treatment response. These rearrangements can be complex, resulting in fusions of multiple chromosomal fragments and generation of derivative chromosomes. Although methods exist for detecting individual fusions, they are generally unable to reconstruct complex chained events. Read More

    Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.
    Cold Spring Harb Mol Case Stud 2018 Apr 2;4(2). Epub 2018 Apr 2.
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
    Well-differentiated (WD) liposarcoma is a low-grade mesenchymal tumor with features of mature adipocytes and high propensity for local recurrence. Often, WD patients present with or later progress to a higher-grade nonlipogenic form known as dedifferentiated (DD) liposarcoma. These DD tumors behave more aggressively and can metastasize. Read More

    Liposarcoma of the Thyroid: A Case Report with a Review of the Literature.
    Eur Thyroid J 2018 Mar 19;7(2):102-108. Epub 2018 Jan 19.
    Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany.
    Background: Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck.

    Patient Findings: We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. Read More

    Identification of inhibitors regulating cell proliferation and FUS-DDIT3 expression in myxoid liposarcoma using combined DNA, mRNA, and protein analyses.
    Lab Invest 2018 Mar 27. Epub 2018 Mar 27.
    Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 1F, 413 90, Gothenburg, Sweden.
    FUS-DDIT3 belongs to the FET (FUS, EWSR1, and TAF15) family of fusion oncogenes, which collectively are considered to be key players in tumor development. Even though over 90% of all myxoid liposarcomas (MLS) have a FUS-DDIT3 gene fusion, there is limited understanding of the signaling pathways that regulate its expression. In order to study cell proliferation and FUS-DDIT3 regulation at mRNA and protein levels, we first developed a direct cell lysis approach that allows DNA, mRNA, and protein to be analyzed in the same sample using quantitative PCR, reverse transcription quantitative qPCR and proximity ligation assay, respectively. Read More

    Single metastasis of myxoid liposarcoma from the thigh to thyroid gland: a case report.
    World J Surg Oncol 2018 Mar 27;16(1):71. Epub 2018 Mar 27.
    Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
    Background: Thyroid metastasis of soft tissue sarcoma is very rare, and the diagnosis is especially difficult when only a single lesion is present.

    Case Presentation: A 50-year-old man was diagnosed with myxoid liposarcoma of the right thigh and treated with wide resection. Two and a half years after the surgery, a growing low-density area was incidentally observed in the right lobe of his thyroid gland on follow-up chest computed tomography. Read More

    Fluorescence in Situ Hybridization (FISH) for Differential Diagnosis of Soft Tissue Sarcomas
    Asian Pac J Cancer Prev 2018 Mar 27;19(3):655-660. Epub 2018 Mar 27.
    Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. Emaile:
    Introduction:Soft tissue sarcomas are rare tumors comprising 1 percent of solid malignancies. The latest edition of WHO soft tissue pathology lists 94 benign and malignant soft tissue tumors. Many of these show a large degree of morphological overlap. Read More

    Four case reports on pelvic tumors with deep venous thromboses as main symptoms and literature review.
    J Cancer Res Ther 2018 ;14(Supplement):S254-S256
    Department of Biomechanics and Medical Information, Beijing University of Technology, Beijing, 100124, China.
    To probe into the reasons for misdiagnoses of pelvic tumor as deep venous thromboses as well as the diagnostic methods and effective treatments on pelvic tumor. Four case reports on misdiagnosing pelvic tumor as deep venous thromboses and further analysis on the causes of misdiagnosis, diagnosis, and treatment with the literature study. The four cases were misdiagnosed as pelvic tumor, which actually were fibroneuroma, myxo. Read More

    Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells.
    Oncotarget 2018 Mar 28;9(17):13154-13166. Epub 2017 Nov 28.
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6902, USA.
    Liposarcoma is a common subtype of soft tissue sarcoma and accounts for 20% of all sarcomas. Conventional chemotherapeutic agents have limited efficacy in liposarcoma patients. Expression and activation of serine/threonine-protein kinase dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) is associated with growth and survival of many types of cancer cells. Read More

    Intramuscular Hibernoma of the Scapular Region Misdiagnosed on Cytology as a Malignant Lesion: A Report of a Rare Case.
    Iran J Pathol 2017 1;12(4):406-409. Epub 2017 Oct 1.
    Department of Oncosurgery, RJSP Cancer Hospital, Ranchi, India.
    Hibernomas are extremely rare benign tumors of adipose tissue characterized by an admixture of brown fat cells with granular, multivacuolated cytoplasm and white fat cells. Hibernomas account for 1.6% of benign adipose tissue tumors and approximately 1. Read More

    [Clinical experience in diagnosis and treatment of primary retroperitoneal liposarcoma].
    Zhonghua Yi Xue Za Zhi 2018 Mar;98(10):773-776
    Department of Urology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    To summarize the experience in diagnosis and treatment of primary retroperitoneal liposarcoma. The clinic data of 73 cases of primary retroperitoneal liposarcoma were reviewed. The age of patients was 23 to 75 years old, with a median age of 53 years. Read More

    Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients.
    BMC Cancer 2018 03 20;18(1):304. Epub 2018 Mar 20.
    Musculoskeletal Oncology, Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, Campus Grosshadern, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
    Background: Liposarcomas are the second most common type of soft tissue sarcomas, 30-50% of these are of myxoid subtype. The aim of this retrospective study was to analyze the local control rate, the metastatic pattern and survival of patients in a consecutive single-institution series.

    Methods: From 1983 to 2015, 43 patients with myxoid liposarcoma of the extremities and trunk wall underwent resections. Read More

    Giant paratesticular liposarcoma: A case report and review of the literature.
    Mol Clin Oncol 2018 Apr 15;8(4):617-622. Epub 2018 Feb 15.
    Department of Urology, Peking University Shenzhen Hospital, Shenzhen 518036, P.R. China.
    Paratesticular liposarcoma is an infrequent tumor characterized by a growing, painless, inguinal or scrotal mass. Only about 200 cases have been reported as of yet in literature, however there are a few cases regarding giant paratesticular liposarcoma measuring over 10 cm. The disease may be commonly misdiagnosed prior to operation. Read More

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