6,717 results match your criteria Liposarcoma


Spindle cell liposarcoma with a TRIO-TERT fusion transcript.

Virchows Arch 2019 Feb 22. Epub 2019 Feb 22.

Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA.

Conventional well-differentiated, dedifferentiated, and myxoid liposarcomas have long been known to harbor numerous typical genetic alterations that allow for diagnosis of these tumors. These include MDM2 and CDK4 amplification in well-differentiated and dedifferentiated liposarcomas as well as FUS-DDIT3 rearrangements in myxoid liposarcoma. More recently, in-frame TRIO-TERT fusion genes have been described in a subset of non-translocation-related sarcomas including myxofibrosarcoma, dedifferentiated liposarcoma, undifferentiated pleomorphic sarcoma, pleomorphic rhabdomyosarcoma, and leiomyosarcoma. Read More

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http://dx.doi.org/10.1007/s00428-019-02545-5DOI Listing
February 2019

Outcome of iliocaval resection and reconstruction for retroperitoneal sarcoma.

J Vasc Surg Venous Lymphat Disord 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Objective: The aim of this study was to investigate the oncologic and surgical outcomes of patients treated with inferior vena cava (IVC) or iliac vein (IV) resection for retroperitoneal sarcoma (RPS). Surgery is the only curative option for patients with primary RPS. The IVC or IV can be directly invaded by RPS or can be the organ of origin of retroperitoneal leiomyosarcoma. Read More

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http://dx.doi.org/10.1016/j.jvsv.2018.10.023DOI Listing
February 2019

Identification of CCDC180 and LRRC4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue.

Am J Pathol 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Recent technical improvements in both mass spectrometry and protein extraction have made it possible to use formalin-fixed, paraffin-embedded (FFPE) tissues for proteome analysis. In this study, comparable proteome analysis of FFPE tissues revealed multiple candidate marker molecules for differentiating atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) from lipoma. One-hundred and eighty-one unique proteins were identified for ALT/WDL. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.013DOI Listing
February 2019

Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma.

Mol Cancer Ther 2019 Feb 20. Epub 2019 Feb 20.

Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Muenster.

Myxoid liposarcoma is an aggressive soft tissue tumor characterized by a specific reciprocal t(12;16) translocation resulting in expression of the chimeric FUS-DDIT3 fusion protein, an oncogenic transcription factor. Similar to other translocation‑associated sarcomas, myxoid liposarcoma are characterized by a low frequency of somatic mutations, albeit a subset of myxoid liposarcoma has previously been shown to be associated with activating PIK3CA mutations. The present study was performed to assess the prevalence of PI3K/Akt signaling alterations in myxoid liposarcoma and the potential of PI3K‑directed therapeutic concepts. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0763DOI Listing
February 2019

Genotyping of circulating cell-free DNA enables non-invasive tumor detection in myxoid liposarcomas.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Plastic and Hand Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years after diagnosis. In this study we investigated circulating free DNA (cfDNA) and tumor-specific genetic alterations therein (circulating tumor DNA, ctDNA) as diagnostic biomarkers. Read More

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http://dx.doi.org/10.1002/ijc.32216DOI Listing
February 2019

A giant retroperitoneal liposarcoma with renal involvement: A case report and literature review.

Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Unidad de Endoscopia y Departamento de Gastroenterología, Hospital CIMA Sanitas, Barcelona, España.

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http://dx.doi.org/10.1016/j.gastrohep.2019.01.003DOI Listing
February 2019

Radiation and Its Impact on Local Recurrence in Extremity and Trunk Well-Differentiated Liposarcomas.

Am Surg 2019 Jan;85(1):52-58

Patients with well-differentiated liposarcomas (WDLPS) of the extremity and trunk are treated primarily with surgical resection, with radiation used for a number of anecdotal reasons, including large size and positive margins. In this study, we evaluate the appropriate role for radiation in these tumors. A retrospective chart review of patients with extremity and trunk soft tissue liposarcomas referred to a free-standing cancer center from January 1995 to December 2011 was performed. Read More

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January 2019

[Li-Fraumeni syndrome].

Orv Hetil 2019 Feb;160(6):228-234

Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6720.

Li-Fraumeni syndrome is a rare genetic disorder predisposing the individual to multiple different cancer types, caused by a germline mutation of the TP53 or CHEK2 genes inherited in an autosomal dominant manner. We hereby describe the case of a family with Li-Fraumeni syndrome. An asymptomatic 40-year-old female was diagnosed with primary lung leiomyosarcoma (T3N0), adenocarcinoma (T1aN0), and inflammatory myofibroblastic tumor, which were surgically removed without further treatment. Read More

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http://dx.doi.org/10.1556/650.2019.31290DOI Listing
February 2019
1 Read

Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG.

Clin Cancer Res 2019 Feb 5. Epub 2019 Feb 5.

Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori.

Background: The role of surgery for first relapse locally recurrent retroperitoneal sarcoma (RPS-LR1) is uncertain. We report outcomes of the largest RPS-LR1 series and propose a new prognostic nomogram.

Methods: Consecutive RPS-LR1 patients without distant metastases who underwent resection at 22 centers (2002-2011) were included. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2700DOI Listing
February 2019
1 Read

Two-stage surgery for intraperitoneal and retroperitoneal multicentric liposarcoma causing hydronephrosis: a case report.

Surg Case Rep 2019 Feb 4;5(1):18. Epub 2019 Feb 4.

Department of Gastroenterological Surgery I, Hokkaido University Hospital, 060-8648, Nishi 5 chome, Kita 14 jyo, Kita-ku, Sapporo-shi, Japan.

Background: Liposarcoma is a soft tissue sarcoma of adipocyte origin. Liposarcoma represents 20-30% of adult soft tissue tumors, which was most frequently seen in the retroperitoneal space in 45% and abdominal space in only 5% of cases, but the multicentric case is unknown. Herein, we describe a rare case of multicentric, large, intra-abdominal and retroperitoneal liposarcoma, one of which had caused infection and pressing the right ureter causing hydronephrosis, which was resected by two-stage surgery. Read More

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http://dx.doi.org/10.1186/s40792-019-0576-yDOI Listing
February 2019
1 Read

Risperidone effects on heterochromatin: the role of kinase signaling.

Clin Exp Immunol 2019 Feb 3. Epub 2019 Feb 3.

The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA.

Epigenetic effects of anti-psychotic medications are poorly understood. We have appropriated a model whereby heterochromatin is established through 24- or 48-h lipopolysaccharide (LPS) treatment, and tested the epigenetic effects of risperidone along the adenylyl cyclase/protein kinase A (AC/PKA) pathway in human liposarcoma cells that express the LPS-sensitive Toll-like receptor (TLR)-4. Human SW872 cells were cultured with LPS and mRNA expression levels and epigenetic modifications of dimethylated lysine 9 of histone 2 (H3K9me2), geterochromatin protein 1γ (HP1γ) and phospho-H3S10 at promoters of interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL1β were measured. Read More

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http://doi.wiley.com/10.1111/cei.13250
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http://dx.doi.org/10.1111/cei.13250DOI Listing
February 2019
1 Read

Developing a clinical scoring system to differentiate deep-seated atypical lipomatous tumor from lipoma of soft tissue.

Asian J Surg 2019 Jan 30. Epub 2019 Jan 30.

Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan. Electronic address:

Background: Atypical lipomatous tumor (ALT) is a low-grade malignancy that frequently occurs at a subfascial anatomical location. While marginal excision is adequate for lipomas, excision with a surgical margin is suggested for ALTs. However, ALTs and lipomas are difficult to differentiate preoperatively, even with the help of imaging studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10159584183076
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http://dx.doi.org/10.1016/j.asjsur.2018.12.012DOI Listing
January 2019
3 Reads

Pleomorphic Sarcomas: The State of the Art.

Surg Pathol Clin 2019 Mar 17;12(1):63-105. Epub 2018 Dec 17.

Department of Pathology, Hospital de Braga, Sete Fontes-Sao Victor, 4710-243 Braga, Portugal; University of Bordeaux, Talence, France. Electronic address:

This article focuses on pleomorphic sarcomas, which are malignant mesenchymal tumors with complex genetic background at the root of their morphologic pleomorphism. They are poorly differentiated tumors that may retain different lines of differentiation, sometimes correlating with clinicopathological or prognostic features. Accurate diagnosis in this group of tumors relies on adequate sampling due to their heterogeneity and assessment with both microscopy and large panels of immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.path.2018.10.004DOI Listing

Update on Lipomatous Tumors with Emphasis on Emerging Entities, Unusual Anatomic Sites, and Variant Histologic Patterns.

Surg Pathol Clin 2019 Mar;12(1):21-33

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO, USA. Electronic address:

This article reviews the histologic patterns of spindle cell/pleomorphic lipoma, well-differentiated liposarcoma, and dedifferentiated liposarcoma in the context of both usual and atypical anatomic presentation. The utility of molecular and immunohistochemical diagnostic modalities to distinguish these entities is described. In addition, more recently described and controversial entities, including atypical spindle cell lipomatous tumor and anisometric cell lipoma, are discussed. Read More

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http://dx.doi.org/10.1016/j.path.2018.11.001DOI Listing
March 2019
1 Read

Mesenchymal Tumors with EWSR1 Gene Rearrangements.

Surg Pathol Clin 2019 Mar;12(1):165-190

Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital NHS Foundation Trust, Robert Aitken Institute for Clinical Research, University of Birmingham, Birmingham B15 2TT, UK.

Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner with other genes to generate recurrent fusion genes. This leads to a spectrum of clinically and pathologically diverse mesenchymal and nonmesenchymal neoplasms, variably manifesting as small round cell, spindle cell, clear cell or adipocytic tumors, or tumors with distinctive myxoid stroma. This review summarizes the growing list of mesenchymal neoplasms that are associated with EWSR1 gene rearrangements. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18759181183007
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http://dx.doi.org/10.1016/j.path.2018.10.007DOI Listing
March 2019
5 Reads

[A giant well-differentiated liposarcoma of the pharyngeal: a case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):52-53

Department of Otorhinolaryngology and Head and Neck Surgery, Henan Province People's Hospital, Zhengzhou 450003, Henan, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.012DOI Listing
January 2019

Retroperitoneal Liposarcoma: A Concern in Inguinal Hernia Repair.

JSLS 2019 Jan-Mar;23(1)

Department of Surgery, Paracelsus Medical University, Salzburg, Austria.

Background And Objectives: The goal of the study was to evaluate retroperitoneal sarcomas with continuous growth into the scrotum through the inguinal canal with regard to diagnostic approach, surgical treatment, and outcome. The analysis is based on a comprehensively documented case and a complete systematic review of published literature. Potential pitfalls are highlighted. Read More

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345196/
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http://dx.doi.org/10.4293/JSLS.2018.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345196PMC
February 2019
3 Reads

Persistent sciatic artery resembles a soft-tissue sarcoma in presentation.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

General Surgery, Dubai Hospital, Dubai, United Arab Emirates.

Persistent sciatic artery (PSA) is a rare vascular anomaly with estimated incidence of 0.03%-0.06%. Read More

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http://dx.doi.org/10.1136/bcr-2018-227250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352791PMC
January 2019

[Pancreaticoduodenectomy for Recurrent Retroperitoneal Liposarcoma].

Gan To Kagaku Ryoho 2018 Dec;45(13):1845-1847

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.

A 56-year-old woman was referred to our hospital with complaints of appetite loss and abdominal distension. Enhanced abdominal computed tomography revealed a giant retroperitoneal tumor. We performed en bloc tumor resection. Read More

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December 2018

[A Case of Giant Retroperitoneal Liposarcoma Resected after Trabectedin Chemotherapy].

Gan To Kagaku Ryoho 2018 Dec;45(13):2132-2134

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

The basic treatment for retroperitoneal liposarcoma is surgical therapy. Since the administration of trabectedin for soft tissue sarcoma has been approved, another option for soft tissue sarcoma treatment has been added. We report a case of radical resection after trabectedin therapy for initially unresectable retroperitoneal liposarcoma. Read More

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December 2018
1 Read

[A Surgically Resected Case of Retroperitoneal Liposarcoma with Metastasis].

Gan To Kagaku Ryoho 2018 Dec;45(13):2108-2110

Dept. of Surgery, Shiga University of Medical Science.

An 80s man presenting with general malaise and anorexia was referred for treatment of abdominal tumor. Abdominal contrast-enhanced CT revealed a tumor in the left renal cavity. The inside of the tumor coexisted with a fat component and a solid component having a contrast effect. Read More

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December 2018

Malignant Interventricular Liposarcoma.

Hellenic J Cardiol 2019 Jan 22. Epub 2019 Jan 22.

Thessaloniki Heart Institute, St Luke's Hospital, Thessaloniki, Greece.

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http://dx.doi.org/10.1016/j.hjc.2019.01.011DOI Listing
January 2019

Diagnostic accuracy of percutaneous biopsy in retroperitoneal sarcoma.

Br J Surg 2019 Jan 24. Epub 2019 Jan 24.

Department of Radiology, Istituto Nazionale Tumori, Milan, Italy.

Background: Percutaneous biopsy is recommended before surgery for suspected retroperitoneal sarcoma (RPS) to confirm the histological diagnosis and guide surgical strategy. The present study aimed to establish the diagnostic accuracy of percutaneous core biopsy with respect to histological diagnosis and tumour grade.

Methods: Data on patients with suspected RPS who underwent percutaneous biopsy followed by surgical resection between 2005 and 2016 at one of two tertiary European sarcoma units were reviewed. Read More

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http://dx.doi.org/10.1002/bjs.11064DOI Listing
January 2019
2 Reads

Paratesticular sarcomas: a case series and literature review.

Ther Adv Urol 2019 Jan-Dec;11:1756287218818029. Epub 2019 Jan 8.

Department of Urology, University Hospital Waterford, Waterford, Ireland.

Paratesticular soft tissue tumours are remarkably rare entities, with malignant subtypes accounting for approximately 30%. Due to the paucity of cases, a consensus on the best treatment has not yet been reached, presenting a diagnostic and therapeutic challenge for clinicians. Although rare, three such cases presented to the care of our institution serving a population of approximately 400,000 in the space of 13 months. Read More

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http://dx.doi.org/10.1177/1756287218818029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329018PMC
January 2019
1 Read

STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience.

Appl Immunohistochem Mol Morphol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

STAT6 stain has proved to be a good surrogate marker for the genetic alteration (NAB2-STAT6 gene fusion) in solitary fibrous tumor (SFT). This study aims to validate the use of STAT6 rabbit monoclonal antibody in differentiating SFT from its histologic mimics. Forty-five cases of SFT and 110 cases from 9 other spindle cell tumors were collected for STAT6 immunostaining. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000745DOI Listing
January 2019
2 Reads

[RETROPERITONEAL LIPOSARCOMA WITH MULTIPLE RECURRENCE OF LUNG METASTASES TREATED BY MULTIMODAL THERAPY CENTERING ON THE OPERATION: A CASE REPORT].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):25-29

Department of Urology, Kanagawa Cancer Center.

A 34-year-old man presented with scrotal pain and slight fever. The scrotal pain was improved by the treatment of antibiotics, but the slight fever remained and an abdominal protuberance appeared. Computed tomography showed a 22 cm abdominal tumor with lipid density. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.25DOI Listing
February 2019
1 Read

Multidisciplinary surgical planning for en bloc resection of malignant primary cervical spine tumors involving 3D-printed models and neoadjuvant therapies: report of 2 cases.

J Neurosurg Spine 2019 Jan 18:1-8. Epub 2019 Jan 18.

1Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland; and.

Effective en bloc resection of primary spinal tumors necessitates careful consideration of adjacent anatomical structures in order to achieve negative margins and reduce surgical morbidity. This can be particularly challenging in the cervical spine, where vital neurovascular and connective tissues are present in the region. Early multidisciplinary surgical planning that includes clinicians and engineers can both optimize surgical planning and enable a more feasible resection with oncological margins. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18607DOI Listing
January 2019
2 Reads

Neoadjuvant isolated limb perfusion in newly diagnosed untreated patients with locally advanced soft tissue sarcomas of the extremities: the Gustave Roussy experience.

Clin Transl Oncol 2019 Jan 17. Epub 2019 Jan 17.

Department of Surgical Oncology, Roussy Cancer Campus Gustave, Villejuif, France.

Background: Limb-sparing surgery in locally advanced soft tissue sarcomas (LA STS) is challenging. The aim of this study is to evaluate upfront isolated limb perfusion (ILP) in untreated patients with LA STS.

Methods: All consecutive patients with LA STS of the limbs deemed borderline or unresectable and treated with upfront ILP as induction treatment between 2003 and 2016 were included. Read More

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http://dx.doi.org/10.1007/s12094-019-02034-wDOI Listing
January 2019
1 Read

Adult renal sarcoma: A rare case of recurrence 13 years after initial resection.

Clin Case Rep 2019 Jan 11;7(1):47-50. Epub 2018 Nov 11.

Department of Urology University of Miami Miller School of Medicine Miami Florida.

Renal sarcoma is a rare and aggressive malignancy without proper guidelines for treatment. Due to the aggressiveness of this disease and the potential for recurrence, we believe that extensive surgical resection with healthy margins may be the best option to treat this condition during both initial resection and resection of the recurrent lesion. Clinical follow-up is also important to monitor for tumor recurrence. Read More

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http://doi.wiley.com/10.1002/ccr3.1911
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http://dx.doi.org/10.1002/ccr3.1911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333076PMC
January 2019
4 Reads

Pleural dedifferentiated liposarcoma: A case report.

Mol Clin Oncol 2019 Jan 5;10(1):132-136. Epub 2018 Nov 5.

Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan.

The present case report describes a rare case of pleural liposarcoma. A 45-year-old Japanese man was hospitalized for increasing left chest pain. Imaging revealed a 10-cm pleural tumor and a 1. Read More

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http://dx.doi.org/10.3892/mco.2018.1757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313927PMC
January 2019
1 Read

AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK.

Int J Mol Sci 2019 Jan 16;20(2). Epub 2019 Jan 16.

Department of Molecular Medicine, College of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea.

Overexpression of Pim kinases has an oncogenic/pro-survival role in many hematological and solid cancers. AZD1208 is a pan-Pim kinase inhibitor that has anti-cancer and anti-adipogenic actions. Here, we investigated the effects of AZD1208 on the growth of 93T449 cells, a differentiated human liposarcoma cell line. Read More

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http://dx.doi.org/10.3390/ijms20020363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359068PMC
January 2019

JAK-STAT signalling controls cancer stem cell properties including chemotherapy resistance in myxoid liposarcoma.

Int J Cancer 2019 Jan 16. Epub 2019 Jan 16.

Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Myxoid liposarcoma (MLS) shows extensive intratumoural heterogeneity with distinct subpopulations of tumour cells. Despite improved survival of MLS patients, existing therapies have shortcomings as they fail to target all tumour cells. The nature of chemotherapy-resistant cells in MLS remains unknown. Read More

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http://doi.wiley.com/10.1002/ijc.32123
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http://dx.doi.org/10.1002/ijc.32123DOI Listing
January 2019
6 Reads

Recurrent oesophageal intraluminal liposarcoma in a woman.

Eur J Cardiothorac Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Radiology, The First Hospital of Jilin University, Changchun, China.

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezy460DOI Listing
January 2019
9 Reads

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors.

Front Oncol 2018 12;8:608. Epub 2018 Dec 12.

Policlinico San Martino-IST, Genova, Italy.

Cyclin-dependent kinases (CDK) 4/6 inhibitors, namely abemaciclib, palbociclib, and ribociclib, interfere with cell cycle progression, induce cell senescence and might promote cancer cell disruption by a cytotoxic T cells-mediated effect. Phase III randomized clinical trials have proven that CDK4/6 inhibitors (CDK4/6i) in combination with several endocrine agents improve treatment efficacy over endocrine agents alone for hormone receptor positive (HR+) HER2 negative (HER2-) metastatic breast cancer (MBC). Based on such results, these combinations have been approved for clinical use. Read More

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http://dx.doi.org/10.3389/fonc.2018.00608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315195PMC
December 2018
2 Reads

Sports activity after soft tissue sarcoma of the lower extremity.

Disabil Rehabil 2019 Jan 8:1-6. Epub 2019 Jan 8.

a Department of Orthopaedic Surgery , Medical University of Vienna, Vienna General Hospital , Vienna , Austria.

Introduction: The aim of this case series was to assess sports activity levels in long-term survivors of soft-tissue sarcomas after multimodal treatment including limb salvaging surgical resection and radio-chemotherapy.

Methods: Thirty-two patients (17 f/15 m) with a mean age of 29 (range 10-44) years at the time of diagnosis and a mean follow-up time of 9 (range 3-21) years following sarcoma were included. Ten patients had been diagnosed with liposarcoma, seven with synovial sarcoma, four with fibrosarcoma, three with undifferentiated pleomorphic sarcomas and the remaining eight patients with different soft-tissue sarcoma entities. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2018.1
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http://dx.doi.org/10.1080/09638288.2018.1520929DOI Listing
January 2019
6 Reads

Scrotal abscess mimicking as intrascrotal liposarcoma.

Urol Case Rep 2019 Mar 23;23:62-64. Epub 2018 Dec 23.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S22144420183039
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http://dx.doi.org/10.1016/j.eucr.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312828PMC
March 2019
4 Reads

68Ga-Prostate-Specific Membrane Antigen PET/CT: Incidental Finding of a Liposarcoma.

Clin Nucl Med 2019 Feb;44(2):e90-e92

From the Institute of Nuclear Medicine, University College of London Hospital, London, United Kingdom.

This case highlights that liposarcoma shows Ga-prostate-specific membrane antigen avidity and should be included in the differential diagnosis of patients with avid muscle lesions to avoid an incorrect diagnosis of metastasis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002389DOI Listing
February 2019
5 Reads

Optimal maximum duration for delaying salvage operation when recurrence of retroperitoneal liposarcoma is suspected: a single-center study.

Int J Clin Oncol 2019 Jan 2. Epub 2019 Jan 2.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, South Korea.

Background: This study was designed to identify the optimal maximum duration for delaying salvage operation when recurrence of retroperitoneal liposarcoma (LPS) is suspected.

Methods: Patients who underwent salvage operation at Samsung Medical Center for recurrent retroperitoneal LPS from January 2000 to December 2015 were reviewed. The time interval between recurrence and operation for recurrence was divided by 1, 2 or 3 months. Read More

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http://link.springer.com/10.1007/s10147-018-01383-w
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http://dx.doi.org/10.1007/s10147-018-01383-wDOI Listing
January 2019
1 Read

Histology driven systemic therapy of liposarcoma-ready for prime time?

Transl Gastroenterol Hepatol 2018 23;3:96. Epub 2018 Nov 23.

Department of Medicine, Hematology and Medical Oncology, Indiana University School of Medicine, Indianapolis, Indiana.

Liposarcomas are a subtype of soft tissue sarcomas arising from adipocytes. These mesenchymal tumors have been sub classified into well differentiated liposarcoma (WDLPS), dedifferentiated liposarcoma (DDLPS), myxoid liposarcoma (MLPS) and pleomorphic liposarcoma (PLPS). This article reviews what has been reported regarding the responsiveness of these sarcoma subtypes to traditional and newly developed systemic therapies. Read More

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http://tgh.amegroups.com/article/view/4712/html
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http://dx.doi.org/10.21037/tgh.2018.11.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286913PMC
November 2018
9 Reads

Integrating therapies for surgical adult soft tissue sarcoma patients.

Transl Gastroenterol Hepatol 2018 2;3:88. Epub 2018 Nov 2.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Sarcomas are an uncommon group of over 50 different individual histological malignancies arising from mesenchymal (non-epithelial or connective) tissues. Overall, they constitute 1% of human malignancies with an annual incidence rate of fewer than 5 patients per million. Sarcoma may arise from any mesenchymal cell lineages including fat, muscle, or other connective tissues. Read More

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http://tgh.amegroups.com/article/view/4678/5445
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http://dx.doi.org/10.21037/tgh.2018.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286915PMC
November 2018
7 Reads

Radiotherapy for retroperitoneal liposarcoma: A report from the Transatlantic Retroperitoneal Sarcoma Working Group.

Cancer 2019 Jan 2. Epub 2019 Jan 2.

Department of Surgery, IRCCS Foundation National Cancer Institute, Milan, Italy.

Background: The current study investigated the role of radiotherapy (RT) in patients with primary nonmetastatic retroperitoneal liposarcomas.

Methods: A total of 607 patients with localized retroperitoneal well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) underwent surgical resection with or without RT at 8 high-volume sarcoma centers (234 patients with WDLPS, 242 patients with grade 1 to 2 DDLPS, and 131 patients with grade 3 DDLPS; grading was performed according to the National Federation of Centers for the Fight Against Cancer [Federation Nationale des Centres de Lutte Contre le Cancer; FNCLCC]). RT was administered in 19. Read More

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http://doi.wiley.com/10.1002/cncr.31927
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http://dx.doi.org/10.1002/cncr.31927DOI Listing
January 2019
14 Reads

Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics.

Authors:
Jason L Hornick

Mod Pathol 2019 Jan 2. Epub 2019 Jan 2.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Diagnosing soft tissue tumors is challenging, even on ample incisional biopsies or resection specimens. There are more than 100 distinct types of soft tissue neoplasms, including more than 80 benign and intermediate mesenchymal tumors and around 40 soft tissue sarcomas. Accurate diagnosis relies first upon recognition of characteristic histologic and cytologic features, including architecture, stromal characteristics, vascular patterns, and dominant cytology; these features may not be represented or apparent in limited core needle biopsy or fine needle aspiration specimens. Read More

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http://dx.doi.org/10.1038/s41379-018-0139-yDOI Listing
January 2019

Giant thymolipoma of mediastinum and neck - initially misdiagnosed as liposarcoma by core needle biopsy.

J Family Med Prim Care 2018 Sep-Oct;7(5):1079-1082

Vascular Surgery and Dialysis Research Center, Razi Clinical Research and Development Center, Guilan University Medical Science, Rasht, Iran.

Thymolipomas are rare benign tumors, constituting one of the differential diagnoses of an anterior mediastinal mass. These tumors may have an indolent, asymptomatic course, often achieving massive dimensions before presentation. When it is symptomatic, respiratory symptoms predominate. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_228_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259522PMC
January 2019
2 Reads

Clear cell papillary renal cell carcinoma: A case report and review of the literature.

World J Nephrol 2018 Dec;7(8):155-160

Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang 410-769, South Korea.

Clear cell papillary renal cell carcinoma (ccpRCC) was recently established as a distinct type of epithelial neoplasm by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. Here, we report a case of partial nephrectomy for a ccpRCC detected during the routine follow-up of a previously treated liposarcoma in a 70-year-old male patient. The patient was referred to the urology department for a right-sided renal mass (size: 2 cm) detected during routine annual imaging follow-up for a malignant right inguinal fibrous histocytoma and liposarcoma that had been diagnosed 6 and 4 years earlier, respectively, and treated with surgery and adjuvant radiation therapy. Read More

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http://dx.doi.org/10.5527/wjn.v7.i8.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305527PMC
December 2018
1 Read

An Unusual Case of Cecal Mesenteric Dedifferentiated Liposarcoma Involving the Ileocolic Artery Resected by Right Hemicolectomy.

Anticancer Res 2019 Jan;39(1):487-490

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Background: Colonic mesenteric dedifferentiated liposarcoma is a rare entity.

Case Report: A 65-year-old male developed a 6 cm diameter right-side intra-abdominal mesenteric mass. A biopsy of the mass was performed and the pathology diagnosis was a spindle cell neoplasm most consistent with low-grade sarcoma. Read More

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http://dx.doi.org/10.21873/anticanres.13138DOI Listing
January 2019
4 Reads

An esophageal tumor unlike others: The fibrovascular polyp.

J Visc Surg 2018 Dec 20. Epub 2018 Dec 20.

Visceral, oncological and endocrine surgery department, université Paris Diderot, hôpital Saint-Louis, AP-HP, Paris, France. Electronic address:

A fibrovascular polyp is a rare benign pseudotumor of the esophagus or the hypopharynx. It comes to light through dysphagia and can lead to death by asphyxiation. CT scan and MRI suggest this diagnosis by highlighting a lobed endoluminal tumor primarily composed of adipose tissue and pedicled on a vessel. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18787886183017
Publisher Site
http://dx.doi.org/10.1016/j.jviscsurg.2018.11.009DOI Listing
December 2018
8 Reads

Proliferative Funiculitis-Like Dedifferentiated Liposarcoma With Mesothelial Glandular Structures: A Diagnostic Pitfall.

Int J Surg Pathol 2018 Dec 24:1066896918820443. Epub 2018 Dec 24.

1 Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia.

Dedifferentiated liposarcoma shows a wide morphological spectrum. We present a case of dedifferentiated liposarcoma of the spermatic cord in a 66-year-old male that was initially misinterpreted as pseudosarcomatous proliferative funiculitis with mesothelial proliferation. Read More

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http://journals.sagepub.com/doi/10.1177/1066896918820443
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http://dx.doi.org/10.1177/1066896918820443DOI Listing
December 2018
9 Reads

The multikinase inhibitor EC-70124 synergistically increased the antitumor activity of doxorubicin in sarcomas.

Int J Cancer 2018 Dec 21. Epub 2018 Dec 21.

Hospital Universitario Central de Asturias - Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.

Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the need for new therapies aimed to overcome this resistance. Multikinase inhibitors provide an efficient way to target several pro-tumorigenic pathways using a single agent and may constitute a valuable strategy in the treatment of sarcomas, which frequently show an aberrant activation of pro-tumoral kinases. Read More

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http://doi.wiley.com/10.1002/ijc.32081
Publisher Site
http://dx.doi.org/10.1002/ijc.32081DOI Listing
December 2018
11 Reads