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    Immunohistochemical Biomarkers of Mesenchymal Neoplasms in Endocrine Organs: Diagnostic Pitfalls and Recent Discoveries.
    Endocr Pathol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
    Mesenchymal neoplasms rarely present in or adjacent to endocrine organs. In this context, the recognition of these rare tumor types can be challenging, with significant potential for misdiagnosis as sarcomatoid carcinomas (i.e. Read More

    Surgery for Abdominal Well-Differentiated Liposarcoma.
    Curr Treat Options Oncol 2018 Jan 16;19(1). Epub 2018 Jan 16.
    Division of Surgical Oncology, Department of Surgery, The Ohio State University, N924 Doan Hall, 410 West 10th Avenue, Columbus, OH, 43210, USA.
    Opinion Statement: Retroperitoneal sarcomas are rare tumors of which liposarcoma is the most common histology. Surgical resection remains the mainstay of therapy, particularly for the well-differentiated subtype. They can grow to massive size before causing symptoms or detection. Read More

    Current principles of surgery for retroperitoneal sarcomas.
    J Surg Oncol 2018 Jan 8. Epub 2018 Jan 8.
    Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
    Surgery for primary retroperitoneal sarcomas (RPS) often requires a technically challenging, en bloc multivisceral resection to optimize outcomes. Surgery may also be appropriate for patients with localized recurrent RPS. Anatomic considerations and tumor biology driven by histologic subtype may guide the extent of resection in patients with RPS. Read More

    Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status.
    Am J Surg Pathol 2018 Jan 5. Epub 2018 Jan 5.
    Departments of Pathology and Clinical Laboratories.
    Malignant peripheral nerve sheath tumor (MPNST) and dedifferentiated liposarcoma (DDLPS) are 2 major types of pleomorphic spindle cell sarcoma. The differentiation of MPNST and DDLPS by histomorphology alone can be problematic. Although MDM2 amplification and PRC2 alteration leading to H3K27me3 deficiency are genetic hallmarks of DDLPS and MPNST, respectively, a small number of MDM2-amplified MPNSTs and H3K27me3-deficient DDLPSs have been reported in the literature. Read More

    Dedifferentiated liposarcoma composed predominantly of rhabdoid/epithelioid cells: a frequently misdiagnosed highly aggressive variant.
    Hum Pathol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Prague.
    Dedifferentiated liposarcoma is one of the most common sarcoma types in adults with a predilection for the retroperitoneum. We have recently encountered 6 cases of DDL composed predominantly of rounded, rhabdoid or epithelioid cells mimicking rhabdoid melanoma, epithelioid rhabdomyosarcoma or undifferentiated carcinoma. Patients were 5 males and one female aged 64 to 81 years (median, 68). Read More

    The potential of the CMB305 vaccine regimen to target NY-ESO-1 and improve outcomes for synovial sarcoma and myxoid/round cell liposarcoma patients.
    Expert Rev Vaccines 2017 Dec 27:1-8. Epub 2017 Dec 27.
    a Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
    Introduction: Synovial Sarcoma (SS) and Myxoid Round Cell Liposarcoma (MRCL) are devastating sarcoma subtypes with few treatment options and poor outcomes in the advanced setting. However, both these diseases may be ideal for novel immunotherapies targeting the cancer-testis antigen, NY-ESO-1. Areas covered: In this review, we discuss the novel NY-ESO-1 targeted vaccine regimen, CMB305. Read More

    Histopathological diagnoses in soft tissue tumours: an experience from a tertiary centre in Malaysia.
    Malays J Pathol 2017 Dec;39(3):209-216
    Universiti Kebangsaan Malaysia Medical Centre, Pathology Department, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.
    Soft tissue tumours are a group of remarkably diverse neoplasms that frequently pose significant diagnostic challenges to general pathologists. This study aimed to compare the agreement of histopathological diagnoses between general pathologists from various referral institutes and the referred soft tissue pathologist in a tertiary centre. The common discrepancies and their causes are also presented here. Read More

    The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer.
    Genetics 2017 Dec 26. Epub 2017 Dec 26.
    University of Bari.
    Genome amplification in the form of rings or giant rod-shaped marker chromosomes is a common genetic alteration in soft tissue tumours. The mitotic stability of these structures is often rescued by perfectly functioning analphoid neocentromeres, which therefore significantly contribute to cancer progression. Here, we disentangled the genomic architecture of many neocentromeres stabilizing marker chromosomes in well-differentiated liposarcoma and lung sarcomatoid carcinoma samples. Read More

    Early detection of metastases using whole-body MRI for initial staging and routine follow-up of myxoid liposarcoma.
    Skeletal Radiol 2017 Dec 23. Epub 2017 Dec 23.
    Department of Diagnostic Radiology, McGill University Health Center, Montreal, Quebec, Canada.
    Objective: To define the role of whole-body MRI (WBMRI) for initial staging and routine follow-up of myxoid liposarcoma (MLS).

    Materials And Methods: A retrospective review of all the patients with MLS who underwent WBMRI for initial staging and routine follow-up at our institution between October 1, 2006, and September 30, 2016 was performed. Patient demographics, clinical presentation, imaging findings, tumor histology, and occurrence and location of metastatic disease were recorded. Read More

    The impact of lipomatous tumors on type 2 diabetes: are adipose-derived tumors metabolically active?
    J Surg Res 2018 Feb 1;222:48-54. Epub 2017 Nov 1.
    Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: The metabolic and immunologic properties of adipose tissue are linked to the pathogenesis of type 2 diabetes mellitus. Lipomatous tumors, such as liposarcomas, are rare but can reach significant size. We hypothesized that some lipomatous tumors are metabolically active and can alter systemic glucose homeostasis. Read More

    Multiply recurrent retroperitoneal liposarcoma.
    J Surg Oncol 2017 Dec 19. Epub 2017 Dec 19.
    Arnot Health, Department of General and Oncologic Surgery, Elmira, NY.
    Retroperitoneal liposarcomas (RPLPS) are rare tumors that represent at least 50% of all retroperitoneal sarcomas. Surgical resection remains the standard of care. Unfortunately, many RPLPS patients will develop a local recurrence and subsequently die in the absence of distant metastasis. Read More

    Systemic Therapy in Metastatic or Unresectable Well-Differentiated/Dedifferentiated Liposarcoma.
    Front Oncol 2017 30;7:292. Epub 2017 Nov 30.
    Royal Marsden Hospital/Institute of Cancer Research, London, United Kingdom.
    Liposarcoma is one of the most common subtypes of soft-tissue sarcoma and consists of three main subtypes, of which well-differentiated liposarcoma and dedifferentiated liposarcoma account for 40-45%. The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting. Recently, eribulin and trabectedin have been approved by the US Food and Drug Administration for recurrent liposarcomas and progress in molecular characterization of these tumors has opened up new and potential novel treatment targets. Read More

    [Anterior Mediastinal Myxoid Liposarcoma Detected by Chest Computed Tomogram in the Patient with Pneumothorax].
    Kyobu Geka 2017 Dec;70(13):1083-1086
    Department of Thoracic Surgery, Sapporo Central Hospital, Sapporo, Japan.
    A 57-year-old woman visited our hospital with left chest pain. Chest computed tomography (CT) scanning showed left pneumothorax with apical bullae and a nodular shadow in the left anterior mediastinum accidentally. However, a week later, we could not detect a mediastinal shadow on chest CT image after healing of left pneumothorax. Read More

    Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications.
    Cancer Treat Rev 2017 Dec 6;63:61-70. Epub 2017 Dec 6.
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young. Dr. South, Los Angeles, CA 90095-6902, USA. Electronic address:
    Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in different tumors are due to the advancement of next-generation sequencing (NGS) technologies such as whole genome sequencing. Recently, many novel chromosomal translocations and gene fusions have been identified in different types of sarcoma through NGS approaches. Read More

    Current management of lipoblastoma.
    Eur J Pediatr 2018 Feb 14;177(2):237-241. Epub 2017 Dec 14.
    Department of Pediatric and Adolescent Surgery, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Kaplan St 14, 4920235, Petah Tikva, Israel.
    Lipoblastoma is a rare and benign tumor arising from embryonal fat cells. It is generally diagnosed in children younger than 3 years of age and can occur in the extremities or on the trunk. We present our series of 10 children with lipoblastoma treated at Schneider Children's Medical Center of Israel between 2011 and 2016. Read More

    [Borderline and malignant mesenchymal tumors of the abdomen].
    Radiologe 2017 Dec 14. Epub 2017 Dec 14.
    Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
    Background: Soft tissue sarcomas are most common mesenchymal malignancies in the abdomen. Their radiologic features are often unspecific and establishing a differential diagnosis to other pathologies can be difficult.

    Objectives: This review presents a selection of the most common mesenchymal abdominal tumors and their imaging characteristics, as well as the associated differential diagnoses. Read More

    Multidisciplinary management of a giant cervico-mediastinal liposarcoma: A case report and literature review.
    Ear Nose Throat J 2017 Dec;96(12):E10-E13
    Department of Otorhinolaryngology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
    Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. Read More

    Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center.
    J Surg Oncol 2017 Dec 11. Epub 2017 Dec 11.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: We investigated whether concomitant organ removal as part of the primary resection of RP WDLPS confers an outcome advantage in patients treated at a major sarcoma center.

    Methods: The departmental sarcoma database was reviewed to identify patients with RP WDLPS who underwent initial surgical resection for primary disease at MD Anderson Cancer Center during the study period 1995-2011. We retrospectively reviewed medical records and examined associations between clinicopathologic variables and overall survival (OS) as well as disease-free survival (DFS). Read More

    Imaging of liposarcomas for clinicians: Characteristic features and differential considerations.
    J Surg Oncol 2017 Dec 11. Epub 2017 Dec 11.
    Department of Diagnostic Radiology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.
    Liposarcoma (LPS) is a malignancy of fat and one of the most common soft tissue sarcomas. There are three major subtypes of LPS: Well-differentiated / dedifferentiated, myxoid, and pleomorphic. We review the imaging features of LPS in the abdomen and extremities, describe features that help differentiate the subtypes, and provides alternative considerations for fat-containing lesions (many benign) that can mimic LPS. Read More

    Asymptomatic giant retroperitoneal mass detected at a medical checkup.
    Clin Case Rep 2017 Dec 16;5(12):2148-2150. Epub 2017 Oct 16.
    Department of GastroenterologyJuntendo University school of MedicineTokyoJapan.
    The differential diagnosis of retroperitoneal mass includes liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma, neurofibroma, stromal tumor, teratoma, and lymphoma. Leiomyosarcoma is rare with poorer prognosis than other soft tissue sarcomas. Soft tissue sarcoma of retroperitoneal origin often remains asymptomatic until tumor enlargement, leading to diagnosis at advanced stages. Read More

    Clinical and Molecular Spectrum of Liposarcoma.
    J Clin Oncol 2018 Jan 8;36(2):151-159. Epub 2017 Dec 8.
    Alex Thomas John Lee, Khin Thway, and Robin Lewis Jones, The Royal Marsden NHS Foundation Trust; Alex Thomas John Lee, Paul H. Huang, and Robin Lewis Jones, The Institute of Cancer Research, London, UK.
    Liposarcomas are rare malignant tumors of adipocytic differentiation. The classification of liposarcomas into four principal subtypes reflects the distinct clinical behavior, treatment sensitivity, and underlying biology encompassed by these diseases. Increasingly, clinical management decisions and the development of investigational therapeutics are informed by an improved understanding of subtype-specific molecular pathology. Read More

    Intensity modulated radiation therapy and surgery for Management of Retroperitoneal Sarcomas: a single-institution experience.
    Radiat Oncol 2017 Dec 8;12(1):198. Epub 2017 Dec 8.
    Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
    Background: Peri-operative radiation of retroperitoneal sarcomas (RPS) is an important component of multidisciplinary treatment. All retrospective series thus far included patients treated with older radiation therapy (RT) techniques including 2D and 3DRT. Intensity modulated radiation therapy (IMRT) allows for selective dose escalation while sparing adjacent organs. Read More

    Gastric liposarcoma resected by laparoscopic total gastrectomy to achieve a wide surgical margin.
    BMJ Case Rep 2017 Dec 5;2017. Epub 2017 Dec 5.
    General surgery, Uwajima city hospital, Uwajima, Ehime prefecture, Japan.
    Gastric liposarcoma is an extremely rare tumour that usually affects the extremities and retroperitoneum. Preoperative diagnosis is difficult, and operative procedures are not well standardised. A 61-year-old woman presented with melaena, epigastric discomfort and palpitations. Read More

    Atypical lipomatous tumor of the hand with transformation to dedifferentiated liposarcoma: a case report.
    Skeletal Radiol 2017 Dec 5. Epub 2017 Dec 5.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Atypical lipomatous tumor/well-differentiated liposarcoma is the most common sarcoma of soft tissue in adults. We describe the clinical, radiologic, and pathologic features of an atypical lipomatous tumor arising within the soft tissue of the left hand of a 68-year-old female that underwent transformation to dedifferentiated liposarcoma and eventually metastasized. At initial presentation, imaging demonstrated an extensively calcified fatty soft tissue mass with displacement of the digits. Read More

    Defining the incidence and clinical significance of lymph node metastasis in soft tissue sarcoma.
    Eur J Surg Oncol 2018 Jan 27;44(1):170-177. Epub 2017 Nov 27.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
    Introduction: The incidence and clinical significance of lymph node metastasis (LNM, N1) in soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS (ETSTS). We sought to define the subgroup of patients with LNM at sarcoma diagnosis across all disease sites and histologies. Read More

    12 years of fighting liposarcoma: a case report.
    Wiad Lek 2017 ;70(5):995-997
    Department Of Surgery And Oncology, Sumy State University, Sumy, Ukraine.
    The proportion of liposarcoma in the structure of cancer incidence is from 10 to 35% of all mesenchymal tumors. This clinical observation describes an 12-year struggle with myxoid liposarcoma of the left upper arm, during which 17 surgeries were performed due to local recurrences, 17 radiation therapy courses and 5 chemotherapy courses were conducted. Clinical observation shows the whole complexity of myxoid liposarcoma treatment. Read More

    Paratesticular Liposarcoma Masquerading as an Inguinal Hernia.
    Urology 2017 Dec 1. Epub 2017 Dec 1.
    Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, Tampa, FL.
    A man with left scrotal swelling felt to represent inguinal hernia underwent computed tomography scan for reported bleeding after prostate biopsy. Computed tomography scan revealed a 15-cm extratesticular left scrotal mass containing both fat and soft tissue components, raising concern for dedifferentiated liposarcoma. At surgery and pathology, the mass was separate from the left testis, epididymis, and spermatic cord. Read More

    Preclinical evaluation of the Aurora kinase inhibitors AMG 900, AZD1152-HQPA, and MK-5108 on SW-872 and 93T449 human liposarcoma cells.
    In Vitro Cell Dev Biol Anim 2018 Jan 1;54(1):71-84. Epub 2017 Dec 1.
    Department of Biomedical Sciences, College of Health Sciences, Midwestern University, 555 31st Street, Downers Grove, IL, 60515, USA.
    Liposarcoma is a malignant soft tissue tumor that originates from adipose tissue and is one of the most frequently diagnosed soft tissue sarcomas in humans. There is great interest in identifying novel chemotherapeutic options for treating liposarcoma based upon molecular alterations in the cancer cells. The Aurora kinases have been identified as promising chemotherapeutic targets based on their altered expression in many human cancers and cellular roles in mitosis and cytokinesis. Read More

    FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway.
    Neoplasia 2018 Jan 28;20(1):44-56. Epub 2017 Nov 28.
    Hospital Universitario Central de Asturias-Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain; CIBER de Cáncer (CIBERONC), Madrid, Spain. Electronic address:
    Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one of the most activated kinases. Here we used a cell-of-origin model of MRCLS and an MRCLS cell line to thoroughly characterize the mechanisms of cell invasion induced by FUS-CHOP using in vitro (3D spheroid invasion assays) and in vivo (chicken chorioallantoic membrane model) approaches. Read More

    A Case of the Resected Lymphohistiocytoid Mesothelioma: BAP1 Is a Key of Accurate Diagnosis.
    Anticancer Res 2017 12;37(12):6937-6941
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Background: Malignant mesothelioma (MM) is a well-known malignant tumor that occurs in the pleura and is histopathologically classified into three subtypes. Lymphohistiocytoid mesothelioma (LHM) is considered a variant of epithelioid MM, and few cases have been reported. First case of LHM was reported by Henderson et al. Read More

    A retroperitoneal dedifferentiated liposarcoma mimicking an ovarian tumor.
    Obstet Gynecol Sci 2017 Nov 19;60(6):598-601. Epub 2017 Oct 19.
    Department of Pathology, Presbyterian Medical Center, Jeonju, Korea.
    A 74-year-old postmenopausal woman visited our gynecology clinic complaining of a palpable abdominal mass. Physical and radiological evaluation indicated that the mass exhibited features of a left ovarian neoplasm showing heterogeneous enhancement. Surgical resection was performed to confirm this suspicion. Read More

    Liposarcoma in the spermatic cord presenting as an inguinal swelling.
    Transl Androl Urol 2017 Oct;6(5):978-980
    Deptartment of Urology, Zealand's Hospital University Roskilde, Roskilde, Denmark.
    Liposarcoma in the spermatic cord is a rare condition with an incidence of 1 per 2.5 million. The condition can present as paratesticular pain and a quick diagnosis is important in order to ensure proper treatment and to improve the prognosis. Read More

    Surgical resection of a massive primary mediastinal liposarcoma with cervical extension.
    Ann R Coll Surg Engl 2017 Nov 28:e1-e3. Epub 2017 Nov 28.
    Department of Thoracic Surgery, Papworth Hospital NHS Foundation Trust, Papworth Everard , Cambridge , UK.
    A 73-year-old man was referred for surgical excision of a massive mediastinal and cervical liposarcoma following neoadjuvant chemotherapy. Surgery was performed via a cervical incision, sternotomy and right posterolateral thoracotomy. The tumour arose from the oesophagus, which underwent extensive dissection and was oversewn with pleura after tumour resection. Read More

    Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement.
    Oncol Lett 2017 Dec 25;14(6):6789-6794. Epub 2017 Sep 25.
    Department of Orthopaedic Surgery, University of Toyama, Toyama, Toyama 930-0194, Japan.
    Myxoid liposarcoma (MLPS) is the second most common histologic subtype of liposarcoma. However, cartilaginous differentiation within MLPS is an extremely rare phenomenon, with only 7 cases of MLPS with cartilaginous differentiation reported to date. The majority of MLPS cases show the t(12;16)(q13;p11) translocation, resulting in the fused in sarcoma-DNA damage-inducible transcript 3 (FUS-DDIT3) fusion gene. Read More

    A case of heavily pretreated metastatic cardiac angiosarcoma treated successfully using eribulin.
    Anticancer Drugs 2018 Jan;29(1):97-101
    Departments of Breast and Medical Oncology.
    Eribulin mesylate (eribulin) is a nontaxane microtubule inhibitor approved in Japan for treating soft tissue sarcoma irrespective of histological subtypes. Thus, our department routinely uses eribulin to treat any histological subtype of sarcoma for patients who have experienced disease progression during standard therapy. However, evidence on the efficacy of eribulin in treating sarcomas that are neither liposarcoma nor leiomyosarcoma is limited. Read More

    High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases.
    Cancer Genet 2017 Dec 22;218-219:69-80. Epub 2017 Sep 22.
    Department of Pathology, University of Washington School of Medicine, Seattle, WA. Electronic address:
    Dedifferentiated liposarcoma (DDLS) is characterized at the molecular level by amplification of genes within 12q13-15 including MDM2 and CDK4. However, other than FNCLCC grade, prognostic markers are limited. We aim to identify molecular prognostic markers for DDLS to help risk stratify patients. Read More

    Liposarcoma of the spermatic cord in a Toy Poodle.
    J Vet Med Sci 2017 Dec 14;79(12):2026-2029. Epub 2017 Nov 14.
    College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
    Liposarcoma of the spermatic cord is extremely rare in dogs and humans. This report describes the clinical signs, typical diagnostic imaging including ultrasound and computed tomography, and treatment of a liposarcoma of the spermatic cord of a Toy Poodle confirmed by histological examination after a surgical procedure. This case highlights the importance of preoperative diagnostic imaging and histopathological examination in dogs with an inguinal or scrotal mass. Read More

    Liposarcoma of the Spermatic Cord –A Rare Pathological Entity.
    Coll Antropol 2017 Mar;41(1):89-93
    Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Read More

    Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets.
    J Hematol Oncol 2017 Nov 13;10(1):173. Epub 2017 Nov 13.
    Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
    Background: Liposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease. The Achilles heel of cancer often is their kinases that are excellent therapeutic targets. However, very limited knowledge exists of therapeutic critical kinase targets in liposarcoma that could be potentially used in disease management. Read More

    Adipocyte Size Variability in Benign and Malignant Lipomatous Tumors and Morphologic Mimics: a Quantitative Definition Using Digital Pathology.
    Hum Pathol 2017 Nov 8. Epub 2017 Nov 8.
    Department of Pathology, University of San Francisco (UCSF), San Francisco, CA 94143.
    Among well-differentiated lipomatous lesions, variability in adipocyte size has been proposed as a morphologic feature of malignancy. Specifically, normal adipose tissue and benign lipomas tend to contain adipocytes of uniform size, whereas atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) are described as containing adipocytes with a conspicuous variation in cell size. However, this proposed variance has never been objectively, quantitatively correlated with diagnosis. Read More

    A giant mediastinal liposarcoma weighing 3500g resected with clam shell approach, a case report with review of literature.
    Int J Surg Case Rep 2017 7;41:292-295. Epub 2017 Nov 7.
    Department of General Thoracic Surgery, National Hospital Organization, Kanagawa National Hospital, 666-1 Ochiai Hadano, Kanagawa 257-8585, Japan.
    Introduction: Liposarcoma is rare in the mediastinum and is less than 1% of all mediastinal tumors. In the present report, we demonstrated our case and summarized the principal treatment of the mediastinal liposarcoma with literature review.

    Presentation Of Case: A 50-year-old man presented at our hospital with complain of dyspnea. Read More

    Historical perspectives and future directions in the surgical management of retroperitoneal sarcoma.
    J Surg Oncol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
    Retroperitoneal sarcomas (RPS) have fascinated and intrigued physicians both past and present. Operative mortality rates were historically very high and complete resection was not possible for the majority of patients until only the last 2 decades. More recently, changes to the surgical approach and clinical decision-making in RPS have improved patient outcomes. Read More

    Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
    • Authors:
    • ,
    Cell 2017 Nov;171(4):950-965.e28
    Cancer Genome Atlas Program Office, National Cancer Institute at NIH, 31 Center Drive, Bldg. 31, Suite 3A20, Bethesda, MD 20892, USA.
    Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Read More

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