6,780 results match your criteria Liposarcoma


Sarcoma Stem Cell Heterogeneity.

Adv Exp Med Biol 2019 ;1123:95-118

Central University Hospital of Asturias-Health Research Institute of Asturias, Oviedo, Spain.

Sarcomas represent an extensive group of divergent malignant diseases, with the only common characteristic of being derived from mesenchymal cells. As such, sarcomas are by definition very heterogeneous, and this heterogeneity does not manifest only upon intertumoral comparison on a bulk tumor level but can be extended to intratumoral level. Whereas part of this intratumoral heterogeneity could be understood in terms of clonal genetic evolution, an essential part includes a hierarchical relationship between sarcoma cells, governed by both genetic and epigenetic influences, signals that sarcoma cells are exposed to, and intrinsic developmental programs derived from sarcoma cells of origin. Read More

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http://dx.doi.org/10.1007/978-3-030-11096-3_7DOI Listing
January 2019

Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.

Expert Opin Investig Drugs 2019 Apr 22:1-7. Epub 2019 Apr 22.

b Division of Molecular Pathology , Institute of Cancer Research , London , UK.

Introduction: Liposarcomas (LPS) are a heterogeneous group of adipocytic soft tissue sarcomas with limited treatment options in the advanced/metastatic setting. Pazopanib is a multi-target tyrosine kinase inhibitor (TKI) with anti-angiogenic and antitumorigenic properties. Whilst targeted agents including TKIs have been extensively studied in other solid tumors and the sarcoma subtype gastrointestinal stromal tumor (GIST), we currently lack effective treatments for the liposarcoma subtype. Read More

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https://www.tandfonline.com/doi/full/10.1080/13543784.2019.1
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http://dx.doi.org/10.1080/13543784.2019.1607291DOI Listing
April 2019
1 Read

[Oesophagus polyps: Giant fibrovascular polyp of the oesophagus disappears!]

Ann Pathol 2019 Apr 16. Epub 2019 Apr 16.

Service d'anatomie et cytologie pathologiques, CHRU de Besançon, 25030 Besançon, France. Electronic address:

The giant fibrovascular polyp of the esophagus is a rare, benign and typical entity described in 1957. This lesion is easily identifiable in its macroscopic and microscopic aspects. However, recent studies question the existence of the giant fibrovascular polyp of the esophagus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02426498193004
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http://dx.doi.org/10.1016/j.annpat.2019.02.011DOI Listing
April 2019
2 Reads

Soft-tissue fat tumours: differentiating malignant from benign using proton density fat fraction quantification MRI.

Clin Radiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Solnavägen 1, 171 77, Stockholm, Sweden; Department of Orthopaedic Surgery, Karolinska University Hospital, Solna, Stockholm, Sweden.

Aim: To evaluate if quantifying proton density fat fraction (PDFF) would be useful in separating lipoma, atypical lipomatous tumour (ALT) and liposarcoma in the extremities and trunk. In addition, differentiating ALT versus non-classical lipomas using magnetic resonance imaging (MRI)-based fatty acid composition (FAC) and three-dimensional (3D) texture analysis was tested.

Material And Methods: This prospective study (undertaken between 2014-2017; comprising 20 women, 21 men) was approved by the Regional Ethical Review Board and informed consent was obtained from all participants. Read More

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http://dx.doi.org/10.1016/j.crad.2019.01.011DOI Listing

Laparoscopic approach to an incidentally found pelvic retroperitoneal liposarcoma: Case report and review.

Medicine (Baltimore) 2019 Apr;98(15):e15184

Unit of Surgical Gynecol Oncology.

Rationale: Well-differentiated liposarcomas (WDLPS) are rare retroperitoneal tumors that can reach significant size as they can grow without constrains before becoming symptomatic. Laparotomic open radical tumor resection represents the most common surgical approach.

Patient Concerns: A mass with "fat fluid level" was found in the right pelvis of an asymptomatic woman undergoing routine transvaginal ultrasound: the preoperative diagnosis was right mature ovarian teratoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000015184DOI Listing
April 2019
1 Read

Distribution and evaluation of bone and soft tissue tumors operated in a tertiary care center.

Acta Orthop Traumatol Turc 2019 Apr 11. Epub 2019 Apr 11.

Department of Orthopaedics and Traumatology, Dr Abdurrahan Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Objective: The aim of this study was to retrospectively evaluate the patients who were operated in our orthopedics and traumatology clinic with the suspection of bone and soft tissue tumors.

Methods: A total of 3133 patients (1146 (46.5%) female and 1318 (53. Read More

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http://dx.doi.org/10.1016/j.aott.2019.03.008DOI Listing
April 2019
1 Read

Preoperative diagnosis and surgical treatment for giant retroperitoneal liposarcoma: A case report.

Int J Surg Case Rep 2019 Apr 6;57:179-182. Epub 2019 Apr 6.

Department of Oncological Surgery, A.O.R.N. "A. Cardarelli", Naples, Italy.

Introduction: The purpose of this article is to present the diagnostic and surgical approach for a giant retroperitoneal sarcoma and to highlight the difficulty of a precise preoperative diagnosis and the extention of surgical resection.

Presentation Of Case: A 63-year-old female patient was admitted at our department with light diffuse abdominal pain, fever and gradual increase of abdominal girth. A CT scan showed a giant fatty tumor occupying left hemiabdomen and indirect findings of renal damage, probably sustained by ureter stretching and urine stasis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461574PMC
April 2019
1 Read

Myxoid liposarcoma: it's a hippo's world.

EMBO Mol Med 2019 Apr 12. Epub 2019 Apr 12.

Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.15252/emmm.201910470DOI Listing

Calreticulin as A Novel Potential Metastasis-Associated Protein in Myxoid Liposarcoma, as Revealed by Two-Dimensional Difference Gel Electrophoresis.

Proteomes 2019 Apr 10;7(2). Epub 2019 Apr 10.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Myxoid liposarcoma (MLS) is a mesenchymal malignancy. To identify innovate seeds for clinical applications, we examined the proteomes of primary tumor tissues from 10 patients with MLS with different statuses of postoperative metastasis. The protein expression profiles of tumor tissues were created, and proteins with differential expression associated with postoperative metastasis were identified by two-dimensional difference gel electrophoresis (2D-DIGE) and mass spectrometry. Read More

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http://dx.doi.org/10.3390/proteomes7020013DOI Listing

[Well-differentiated liposarcoma of the retropharyngeal space: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):378-380

Liposarcomas represent a significant proportion of softtissue sarcomas. However, rare cases of primary liposarcoma of the throat have been reported in the literature and they are exceedingly rare in the retropharyngeal space. The present study report a case of a 60 year old patient with retropharyngeal liposarcoma. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.022DOI Listing

Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells.

Sci Rep 2019 Apr 8;9(1):5759. Epub 2019 Apr 8.

Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan.

An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor prognosis in a subset of STS cases. Recently, eribulin, a microtubule dynamics inhibitor, has demonstrated efficacy and is approved in patients with advanced/metastatic liposarcoma and breast cancer. However, mechanisms of eribulin resistance and/or insensitivity remain largely unknown. Read More

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http://dx.doi.org/10.1038/s41598-019-42300-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453888PMC
April 2019
1 Read

Establishment and characterization of histologically and molecularly stable soft tissue sarcoma xenograft models for biological studies and preclinical drug testing.

Mol Cancer Ther 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven.

Soft tissue sarcomas (STS) represent a heterogeneous group of rare, malignant tumors of mesenchymal origin. Reliable in vivo sarcoma research models are scarce. We aimed to establish and characterize histologically and molecularly stable patient-derived xenograft (PDX) models from a broad variety of STS subtypes. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1045DOI Listing
April 2019
4 Reads

[Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):282-287

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinicopathological features, diagnosis and differential diagnosis of dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features. Five cases of DDLPS with IMT-like features were collected from the First Affiliated Hospital of Nanjing Medical University, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine and the First People's Hospital of Qinzhou between 2013 and 2018. EnVision method and fluorescence in situ hybridization (FISH) were used to detect the immunophenotype of the tumor cells and the profile of MDM2 gene amplification respectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.004DOI Listing
April 2019
1 Read

Ischiorectal fossa: benign and malignant neoplasms of this "ignored" radiological anatomical space.

Abdom Radiol (NY) 2019 Apr 6. Epub 2019 Apr 6.

Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Purpose: To review the pertinent anatomy and the imaging features of common and uncommon benign and malignant neoplasms and masses of the ischiorectal fossa.

Results: The ischiorectal or ischioanal fossa is the largest space in the anorectal region. The benign neoplasms that develop in the ischiorectal originate from the different components that forms the fossa including vascular tumors such as aggressive angiomyxoma or hemangioma; neural tumors as plexiform neurofibroma or schwannoma; fat tumors as lipoma; skin/skin appendages tumors as hidradenoma papilliferum; smooth or skeletal muscle tumors as solitary fibrous tumor. Read More

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http://dx.doi.org/10.1007/s00261-019-01930-7DOI Listing
April 2019
2 Reads

Spermatic Cord Liposarcoma.

Authors:
Lori A Erickson

Mayo Clin Proc 2019 Apr;94(4):737-738

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2019.02.005DOI Listing

Dedifferentiated retroperitoneal large liposarcoma and laparoscopic treatment: Is it possible and safe? The first literature case report.

Int J Surg Case Rep 2019 Mar 26;57:113-117. Epub 2019 Mar 26.

Department of Surgical, Oncological and Oral Sciences, Section of General and Urgent Surgery, University of Palermo, Italy. Electronic address:

Introduction: Soft tissue sarcomas are rare neoplasms often characterized by local invasiveness and distant metastasis with poor prognosis for affected patients. Among the most frequent sarcomas we find well-differentiated and dedifferentiated liposarcomas characterized by a better survival compared to the other histological types. When it is possible the only curative treatment for these neoplasms is surgical resection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193014
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http://dx.doi.org/10.1016/j.ijscr.2019.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446056PMC
March 2019
4 Reads

CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma.

Mol Med Rep 2019 May 28;19(5):4205-4212. Epub 2019 Mar 28.

Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China.

CBX3, namely chromobox protein homolog 3, a member of the heterochomatin protein 1 (HP1) family, has been shown to be associated with the tumorigenesis of various types of cancer. The aim of the present study was to assess the biological role and the clinicopathological importance of CBX3 in osteosarcoma. The Oncomine database was utilized to determine the CBX3 expression in sarcoma patients. Read More

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http://dx.doi.org/10.3892/mmr.2019.10104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470990PMC
May 2019
4 Reads

Primary intrathoracic liposarcoma: a clinical analysis of 31 cases.

Cancer Commun (Lond) 2019 Apr 2;39(1):15. Epub 2019 Apr 2.

Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P. R. China.

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http://dx.doi.org/10.1186/s40880-019-0358-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444813PMC
April 2019
1 Read

Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019838296

6 Department of Orthopedic Surgery and Musculoskeletal Oncology, University of Pittsburgh Medical Center and Hillman Cancer Institute, Pittsburgh, PA, USA.

Background And Objectives:: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution.

Methods:: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Read More

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http://dx.doi.org/10.1177/2309499019838296DOI Listing

Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date.

Authors:
Lee D Cranmer

Onco Targets Ther 2019 18;12:2047-2062. Epub 2019 Mar 18.

Division of Medical Oncology, University of Washington, Seattle, WA, USA,

Anthracyclines, and doxorubicin in particular, remain a mainstay of sarcoma therapy. Despite modest activity and significant toxicities, no cytotoxic monotherapy has yet yielded superior overall survival over doxorubicin for therapy of advanced soft tissue sarcomas in a randomized trial. Similarly, combination regimens have also been unable to overcome doxorubicin in terms of overall survival. Read More

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https://www.dovepress.com/spotlight-on-aldoxorubicin-inno-20
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http://dx.doi.org/10.2147/OTT.S145539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430065PMC
March 2019
10 Reads

Atypical Lipomatous Tumors: Does Our Inconsistent Terminology Have Patient Repercussions? Results of a Meta-Analysis.

Am J Clin Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

Objectives: Misnaming low-grade lipomatous tumors poses a clinical and medicolegal challenge, potentially subjecting patients to expensive and unnecessary surgeries. The terms atypical lipomatous tumor (ALT) and "well-differentiated" liposarcoma (WDL) have been used interchangeably in pathology reports, scholarly works and consensus recommendations, creating vagaries between low-virulence extremity tumors and retroperitoneal disease with metastatic potential.

Methods: A systematic review was performed on all studies that reported on the local recurrence rate and metastasis of ALTs and WDLs in living human subjects. Read More

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http://dx.doi.org/10.1097/COC.0000000000000540DOI Listing
March 2019
1 Read

Myxoid liposarcoma associated with adalimumab treatment: A case report.

Mol Clin Oncol 2019 Apr 27;10(4):454-456. Epub 2019 Feb 27.

Department of Radiotherapy, Meixoeiro Hospital, CHUVI, 36200 Vigo, Spain.

Biological agents that suppress inflammation, such as tumour necrosis factor (TNF-α) inhibitors, are being successfully used at an increasing frequency for the treatment of chronic inflammatory diseases, such as psoriasis. However, these drugs are not free of side effects, and although the general rates of malignancy in patients using anti-TNF-α therapies are not high, certain tumours of cutaneous origin, particularly carcinomas, have been reported. We herein present the case of a 47-year-old female patient with moderate-to-severe psoriasis for 20 years under treatment with adalimumab administered at the standard dose of 40 mg, injected subcutaneously each fortnight, with good efficacy. Read More

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http://dx.doi.org/10.3892/mco.2019.1817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425503PMC
April 2019
2 Reads

[Two cases of unilateral chilblains associated with monoparesis].

Ann Dermatol Venereol 2019 Mar 28. Epub 2019 Mar 28.

Médecine, Sorbonne université, 75013 Paris 06, France; Service de dermatologie, UF de dermatologie vasculaire, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.

Background: Chilblains are inflammatory dermal lesions associated with hypersensitivity to cold, and they occur on the extremities bilaterally and symmetrically. Their onset during the course of pro-thermogenic and autoimmune diseases has been widely reported, but the association with predisposing locoregional causes is not well known.

Patients And Methods: Case 1: a 57-year-old man, who smoked 80 packets per year, presenting a deficit of the levator muscles in his right foot following lumbar sciatica with paralysis of L5, consulted for unilateral necrotic lesions of the toes recurring each winter in the paralysed limb only. Read More

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http://dx.doi.org/10.1016/j.annder.2019.01.022DOI Listing
March 2019
5 Reads

Prognostic factors of patients with extremity myxoid liposarcomas after surgery.

J Orthop Surg Res 2019 Mar 28;14(1):90. Epub 2019 Mar 28.

Department of Orthopaedics, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310000, Zhejiang, People's Republic of China.

Background: Extremity myxoid liposarcoma (MLS) is a rare soft tissue sarcoma in adults. We performed this study to define distinctive clinical features of extremity MLS by assessing prognostic factors.

Methods: Between 1973 and 2015, 1756 patients with extremity MLS who underwent surgical resection were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute. Read More

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http://dx.doi.org/10.1186/s13018-019-1120-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438008PMC
March 2019
1 Read

Primary retroperitoneal liposarcoma with extensive ossification: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e14996

Department of Hepatopancreatobiliary Surgery.

Rationale: Primary retroperitoneal liposarcoma, which originates from mesenchymal tissues, can rarely present with extensive ossification.

Patient Concerns: A 41-year-old male patient presented with a chief complaint of discomfort around the waist for 2 months.

Diagnoses: Computerized tomography (CT) and magnetic resonance imaging suggested a lesion of approximately 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000014996DOI Listing

[Comparison of Imaging and Pathologic Findings of Retroperitoneal Dedifferentiated Liposarcoma].

Zhonghua Zhong Liu Za Zhi 2019 Mar;41(3):223-228

Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the imaging appearance of CT and MRI in retroperitoneal dedifferentiated liposarcoma (DDL) based on pathological findings. Twelve patients with retroperitoneal DDL (13 lesions) who were surgically and pathologically confirmed were retrospectively collected in the Cancer Hospital of Chinese Academy of Medical Sciences. The correlation of CT and MRI features with histopathologic findings was analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.03.013DOI Listing

Orbital Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Masquerading as Pleomorphic Lipoma: A Diagnostic Challenge.

Ophthalmic Plast Reconstr Surg 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology, Wills Eye Hospital, Thomas Jefferson University.

Atypical lipomatous tumor/well-differentiated liposarcoma is a common neoplasm of the superficial and deep soft tissues of the extremities, trunk, and retroperitoneum. Atypical lipomatous tumor/well-differentiated liposarcoma is very rare in the orbit, with only 19 previously reported cases. The authors describe a 22-year-old woman who presented with an 8-month history of diplopia and was found to have an orbital mass on MRI. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001378DOI Listing
March 2019
1 Read

The role of 18F-FDG PET/CT in soft tissue sarcoma.

Nucl Med Commun 2019 Mar 22. Epub 2019 Mar 22.

IRCCS Rizzoli Orthopaedic Institute.

Introduction: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9841
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http://dx.doi.org/10.1097/MNM.0000000000001002DOI Listing
March 2019
3 Reads

Dedifferentiated liposarcoma of the musculoskeletal system: expanded MR imaging spectrum from predominant fatty mass to non-fatty mass.

Acta Radiol 2019 Mar 24:284185119833060. Epub 2019 Mar 24.

1 Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background: The morphology of musculoskeletal dedifferentiated liposarcoma was previously reported as well-defined non-lipomatous masses juxtaposed with fatty tumors.

Purpose: To establish a new spectrum of magnetic resonance imaging (MRI) findings for dedifferentiated liposarcoma according to the quantity and distribution of the non-fatty component in the tumor.

Material And Methods: This study consisted of a retrospective review of MRI of 14 patients with a total of 18 histopathologically proven dedifferentiated liposarcoma lesions in the musculoskeletal area. Read More

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http://dx.doi.org/10.1177/0284185119833060DOI Listing
March 2019
11 Reads

Short tau inversion recovery magnetic resonance imaging for staging and screening in myxoid liposarcoma.

J Orthop 2019 May-Jun;16(3):206-210. Epub 2019 Feb 28.

Department of Orthopaedic Surgery, Loma Linda University Medical Center, 11406 Loma Linda Drive, Suite 218, Loma Linda, CA, 92354, USA.

Purpose: Myxoid liposarcoma has a propensity to metastasize to bone. MRI is the preferred modality for detecting bone disease. We evaluated multiple MRI sequences to determine an optimal screening method. Read More

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http://dx.doi.org/10.1016/j.jor.2019.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411606PMC
February 2019

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma.

Nat Commun 2019 03 22;10(1):1353. Epub 2019 Mar 22.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and transcriptional addiction in this disease, we chart super-enhancer structures in both LPS tissues and cell lines. We identify a bromodomain and extraterminal (BET) protein-cooperated FUS-DDIT3 function in myxoid LPS and a BET protein-dependent core transcriptional regulatory circuitry consisting of FOSL2, MYC, and RUNX1 in de-differentiated LPS. Read More

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http://dx.doi.org/10.1038/s41467-019-09257-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430783PMC
March 2019
1 Read
10.742 Impact Factor

Requirement for YAP1 signaling in myxoid liposarcoma.

EMBO Mol Med 2019 Mar 21. Epub 2019 Mar 21.

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany

Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive. Here we show, using an unbiased functional genomic approach, that FUS-DDIT3-expressing mesenchymal stem cells and MLS cell lines are dependent on YAP1, a transcriptional co-activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS Mechanistically, FUS-DDIT3 promotes YAP1 expression, nuclear localization, and transcriptional activity and physically associates with YAP1 in the nucleus of MLS cells. Read More

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http://dx.doi.org/10.15252/emmm.201809889DOI Listing
March 2019
2 Reads

Clinicopathologic evaluation of uterine smooth muscle tumors of uncertain malignant potential (STUMP): A single center experience.

J Gynecol Obstet Hum Reprod 2019 Mar 18. Epub 2019 Mar 18.

Department of Gynecologic Oncology, University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey.

Objective: To investigate the clinical outcomes and histopathological features of uterine smooth muscle tumors of uncertain malignant potential (STUMP).

Methods: The study analysed cases diagnosed with uterine STUMP in a tertiary center, between January 2003 and September 2018. We investigated the clinical, operative and histopatholologic data of the cases. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.03.003DOI Listing
March 2019
1 Read

New research strategies in retroperitoneal sarcoma. The case of TARPSWG, STRASS and RESAR: making progress through collaboration.

Curr Opin Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose Of Review: Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were poorly understood. Recently, collaborations between individual centers have led to an unprecedented collection of retrospective and prospective data and successful recruitment to the first randomized trial as described here.

Recent Findings: A debate about the beneficial role of extended surgery in RPS triggered an initial collaboration between Europe and North America, the TransAtlantic RetroPeritoneal Sarcoma Working Group (TARPSWG). Read More

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http://dx.doi.org/10.1097/CCO.0000000000000535DOI Listing
March 2019
1 Read

Real-World Experiences with Pazopanib in Patients with Advanced Soft Tissue and Bone Sarcoma in Northern California.

Med Sci (Basel) 2019 Mar 18;7(3). Epub 2019 Mar 18.

Internal Medicine Residency Program, Kaiser Permanente, Oakland, CA, USA.

Pazopanib was approved for advanced soft tissue sarcoma as a second- or third-line therapy based on the clinical trial "Pazopanib for metastatic soft-tissue sarcoma" (PALETTE). We hypothesized that the real-world experiences may be significantly different from the clinical trial results. We analyzed the response pattern of patients with advanced soft tissue and bone sarcoma who received pazopanib treatment between 1 January 2011 and 31 October 2018 in Kaiser Permanente Northern California. Read More

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http://dx.doi.org/10.3390/medsci7030048DOI Listing
March 2019
1 Read

Double minute chromosomes harboring MDM2 amplification in a pediatric atypical lipomatous tumor.

Genes Chromosomes Cancer 2019 Mar 19. Epub 2019 Mar 19.

Laboratory of Solid Tumors Genetics, Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284/INSERM U1081, Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Nice, Faculté de Médecine, Nice, France.

Adipocytic tumors are rare in children and are mostly benign. Less than 25 cases of pediatric well-differentiated liposarcoma (WDLPS), atypical lipomatous tumors (ALT), and dedifferentiated liposarcoma (DDLPS) have been reported. Among them, only three cases were genetically analyzed. Read More

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http://dx.doi.org/10.1002/gcc.22754DOI Listing
March 2019
1 Read

Pancreatic liposarcoma: A rare cause of pancreatic mass in adult.

Authors:
D Cao J Wang L Guo

J Gastroenterol Hepatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, The First Hospital of Jilin University, Changchun, China.

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http://dx.doi.org/10.1111/jgh.14621DOI Listing

Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY-ESO-1 and MAGE-A4 in high-grade soft-tissue sarcoma.

Oncol Lett 2019 Apr 14;17(4):3937-3943. Epub 2019 Feb 14.

Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Mie 514-8507, Japan.

The aim of the present study was to explore the expression of the cancer testis antigens New York-esophageal squamous cell carcinoma (NY-ESO)-1 and melanoma-associated antigen (MAGE)-A4 in high-grade soft-tissue sarcoma and to evaluate their association with the standard clinical-pathological features of surgically treated high-grade sarcoma patients. The study included 82 patients, and NY-ESO-1 and MAGE-A4 antigen expression was analyzed immunohistochemically. The results revealed NY-ESO-1- and MAGE-A4-positive staining in 58. Read More

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http://dx.doi.org/10.3892/ol.2019.10044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403520PMC
April 2019
1 Read

Primary parotid liposarcoma.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 12. Epub 2019 Mar 12.

School of Medicine, University of Zagreb, Šalata 3b, Zagreb, Croatia.

Introduction: Primary liposarcoma is very rare in the parotid gland. To date, only 8 cases of primary parotid liposarcoma have been reported. The aim of this study is to report on a case of primary parotid liposarcoma highlighting the complexity of its treatment and analyze treatment outcomes of other reported cases. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.01.013DOI Listing
March 2019
1 Read

Primary colonic liposarcomatosis: report of a case with review of literature.

Autops Case Rep 2019 Jan-Mar;9(1):e2018056. Epub 2019 Jan 14.

All India Institute of Medical Sciences, Department of Pathology and Laboratory Medicine, Bhubaneswar, Orissa, India.

The colon is a rare site of occurrence of liposarcoma, as either the primary site or by secondary involvement from a retroperitoneal liposarcoma. Liposarcomatosis denotes simultaneous occurrence of multiple liposarcomas. There are only 17 cases of primary colonic liposarcoma reported in the English literature-one of which was primary colonic liposarcomatosis. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394358PMC
January 2019
7 Reads

Molecular updates in adipocytic neoplasms.

Semin Diagn Pathol 2019 Mar 28;36(2):85-94. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

Adipocytic neoplasms include a diversity of both benign tumors (lipomas) and malignancies (liposarcomas), and each tumor type is characterized by its own unique molecular alterations driving tumorigenesis. Work over the past 30 years has established the diagnostic utility of several of these characteristic molecular alterations (e.g. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.003DOI Listing
March 2019
2 Reads

Kidney sparing giant retroperitoneal liposarcoma: Case report and literature review.

Int J Surg Case Rep 2019 21;56:70-73. Epub 2019 Feb 21.

Department of Digestive Surgery, Dr Ramelan Navy Hospital Surabaya, Surabaya, Indonesia.

Introduction: Liposarcoma is the most common variant of soft tissue sarcoma. It often originates in retroperitoneum or perirenal fat. Early diagnosis is extremely difficult due to its location in the retroperitoneum that allows for room for growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193006
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http://dx.doi.org/10.1016/j.ijscr.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411585PMC
February 2019
5 Reads

A contemporary review of myxoid adipocytic tumors.

Authors:
David Creytens

Semin Diagn Pathol 2019 Mar 28;36(2):129-141. Epub 2019 Feb 28.

Department of Pathology, Ghent University and Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University and Ghent University Hospital, Ghent, Belgium. Electronic address:

Myxoid adipocytic tumors encompass a broad heterogeneous group of benign and malignant adipocytic tumors, which are typically myxoid (e.g. myxoid liposarcoma, lipoblastoma and lipoblastoma-like tumor of the vulva) or may occasionally appear predominantly myxoid (e. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.008DOI Listing
March 2019
1 Read

Pleomorphic liposarcoma: Updates and current differential diagnosis.

Semin Diagn Pathol 2019 Mar 28;36(2):122-128. Epub 2019 Feb 28.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States. Electronic address:

Pleomorphic liposarcoma is the least common but most aggressive subtype of liposarcoma. Tumors most commonly arise in the deep soft tissues of the extremities in adult patients. Pleomorphic liposarcoma has no specific immunohistochemical or molecular genetic features, and the presence of lipoblasts remains the sole diagnostic criterion. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.007DOI Listing

Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.

Authors:
Khin Thway

Semin Diagn Pathol 2019 Mar 28;36(2):112-121. Epub 2019 Feb 28.

Sarcoma Unit, Royal Marsden Hospital, 203 Fulham Road, London SW3 6JJ, United Kingdom. Electronic address:

Well-differentiated liposarcoma (WDL)/atypical lipomatous tumor and dedifferentiated liposarcoma (DDL) together comprise the largest subgroup of liposarcomas, and constitute a histologic and behavioral spectrum of one disease. WDL and DDL typically occur in middle-aged to older adults, particularly within the retroperitoneum or extremities. WDL closely resembles mature adipose tissue, but typically shows fibrous septation with variable nuclear atypia and enlargement. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.006DOI Listing

Adipocytic tumors in Children: A contemporary review.

Semin Diagn Pathol 2019 Mar 28;36(2):95-104. Epub 2019 Feb 28.

Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, United States. Electronic address:

Adipocytic neoplasms in the pediatric population demonstrate a different histologic spectrum and frequency than in adults. The vast majority of these tumors are benign, with lipoma being the most common entity. The identification of signature cytogenetic and molecular alterations for certain lesions, such as PLAG1 gene rearrangement in lipoblastoma and FUS-DDIT3 fusion in myxoid liposarcoma, has been helpful in approaching these neoplasms and aiding in confirming the diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570193001
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http://dx.doi.org/10.1053/j.semdp.2019.02.004DOI Listing
March 2019
5 Reads
1.796 Impact Factor

Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review.

Respir Med Case Rep 2019 21;26:281-284. Epub 2019 Feb 21.

Division of Pulmonary and Critical Care Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USA.

Background: Liposarcoma (LPS) is the second most common type of soft tissue sarcoma, accounting for approximately 15-20% of all the sarcomas. Primary intrathoracic LPS, however, is quite rare. LPS is a malignant mesenchymal tumor, comprised of lipogenic tissue with varying degrees of atypia. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389794PMC
February 2019
1 Read