7,979 results match your criteria Liposarcoma

Prognosis and survival of patients diagnosed with well-differentiated and dedifferentiated retroperitoneal liposarcoma.

Cir Esp (Engl Ed) 2022 Jun 23. Epub 2022 Jun 23.

Departamento de Ciencias Morfológicas y Sociosanitarias, Facultad de Medicina y Enfermería, Universidad de Córdoba, Córdoba, Spain; Servicio de Anatomía Patológica, Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain; Grupo de Investigación en Regeneración Muscular (REGMUS), Universidad de Córdoba, Córdoba, Spain. Electronic address:

Objectives: The main objective is to establish the overall survival and disease-free survival profiles regarding the patients with retroperitoneal liposarcoma, making a comparison based on the well-differentiated and dedifferentiated histological subtypes. The secondary objectives are to descriptively analyze the clinical characteristics of said patients and to identify and analyze other independent variables that might modify these survival profiles significantly.

Methods: An observational and analytical study was performed using a retrospective historical cohort that was followed prospectively. Read More

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Dedifferentiated liposarcoma (DDLPS) in the rectum: A case report.

J Int Med Res 2022 Jun;50(6):3000605221102081

Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Dedifferentiated liposarcoma (DDLPS) is a rare subtype of liposarcoma with a poor prognosis. This current case report describes a rectal DDLPS in a 68-year-old Chinese male that presented with lower abdominal pain and weight loss. Computed tomography and magnetic resonance imaging were undertaken to evaluate the tumour. Read More

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Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER Stress.

Biomolecules 2022 Jun 17;12(6). Epub 2022 Jun 17.

Department of Molecular Medicine, College of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea.

Liposarcoma is a rare and heterogeneous soft tissue malignant tumor and has a significant impact on mortality with a poor prognosis. To date, there is no effective treatment for liposarcoma, whereas surgical resection is only the gold treatment with numerous adverse effects. Here we investigated whether tetrandrine inhibits the growth of SW872 human malignant liposarcoma cells. Read More

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Mediastinal dedifferentiated liposarcoma resection with trachea compression via the masaoka approach.

Asian J Surg 2022 Jun 21. Epub 2022 Jun 21.

Division of Thoracic Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan. Electronic address:

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Giant Retroperitoneal Mass: Case Report in a Primary Hospital and Review of the Literature.

Maedica (Bucur) 2022 Mar;17(1):226-229

Department of General Surgery, S. Salvatore Hospital, Paterno', S. M. Addolorata Hospital, Biancavilla, Italy.

Retroperitoneal liposarcoma (RPLS) is a rare form of cancer that mostly affects adults. Symptoms may be undetected unless the tumor begins to grow. Diagnosis is made when the tumor is large and puts vital organs such as the pancreas, liver, kidneys at risk. Read More

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miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer.

BMC Cancer 2022 Jun 22;22(1):689. Epub 2022 Jun 22.

Ningbo Medical Centre Lihui Li Eastern Hospital, Ningbo University, Jiangnan Road No.1111, Ningbo, 330212, Zhejiang, China.

Background: The mechanism of long non-coding RNA MIR137HG in human gastric cancer (GC) is currently unknown. In the present study, we aimed to explore the function and mechanism of MIR137HG in gastric cancer.

Methods: The expression of lncRNA-MIR137HG in 69 gastric cancer samples and their paired surgical margin (SM) tissue samples were tested by QRT-PCR. Read More

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New molecular entities of soft tissue and bone tumors.

Curr Opin Oncol 2022 Jun 23. Epub 2022 Jun 23.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Purpose Of Review: The advances of molecular techniques have led to the refinement of the classification of mesenchymal tumors, leading to newly introduced entities in the recently published fifth edition of the WHO Classification of Soft Tissue and Bone Tumors, which are discussed in this review.

Recent Findings: For the first time, entities are included of which the name refers to the underlying molecular alteration including round cell sarcoma with EWSR1-non-ETS fusions, CIC-rearranged sarcoma, and sarcoma with BCOR genetic alteration. EWSR1-SMAD3-positive fibroblastic tumor and NTRK-rearranged spindle cell neoplasm are provisionally included as 'emerging' entities based on the underlying molecular alteration, though the entity still needs to be better defined. Read More

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Pelvic soft tissue sarcomas.

Eur J Surg Oncol 2022 Jun 4. Epub 2022 Jun 4.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

Pelvic soft tissue sarcomas (PSTS) are a rare, heterogeneous group of tumors. They have been usually analyzed with retroperitoneal sarcomas (RPS), but actually have key differences. Due to their unique anatomic location, symptomatic presentation of PSTS may be more common than RPS. Read More

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Giant esophageal liposarcoma with squamous cell carcinoma resected via the cervical approach: a case report.

Surg Case Rep 2022 Jun 20;8(1):118. Epub 2022 Jun 20.

Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33 Motomachi, Naka-ku, Hiroshima, 730-8518, Japan.

Background: Liposarcoma is one of the most common soft tissue sarcomas, but is extremely rarely found in the esophagus. There have been no reports of esophageal liposarcoma together with superficial carcinoma of the esophagus. Here, we report a patient who underwent complete resection of esophageal liposarcoma with carcinoma via a cervical approach. Read More

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Recurrent pneumothorax in a patient with liposarcoma as either a complication of lung micrometastasis or a potential adverse event from antibiotic therapy: A case report.

Oncol Lett 2022 Jul 12;24(1):202. Epub 2022 May 12.

Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', I-47014 Meldola, Italy.

Spontaneous pneumothorax (PNX) is an infrequent manifestation of primary lung cancer, soft tissue sarcoma and metastasis. There are no easily accessible data in the literature regarding the correlation between PNX and antibiotics, whereas cases of PNX following chemotherapy have been observed. Only 1-10% of treatment-related adverse events are estimated to be reported to the Food and Drug Administration. Read More

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Development and Validation of a Prognostic Model to Predict the Prognosis of Patients With Retroperitoneal Liposarcoma: A Large International Population-Based Cohort Study.

Front Oncol 2022 2;12:857827. Epub 2022 Jun 2.

State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Background: Retroperitoneal liposarcomas (RPLs), sarcoma of mesenchymal origin, are the most common soft tissue sarcomas (STS) of the retroperitoneum. Given the rarity of RPLs, the prognostic values of clinicopathological features in the patients remain unclear. The nomogram can provide a visual interface to aid in calculating the predicted probability that a patient will achieve a particular clinical endpoint and communication with patients. Read More

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Mid-term outcomes in the treatment of retroperitoneal sarcomas: a 12-year single-institution experience.

Med Glas (Zenica) 2022 Aug 1;19(2). Epub 2022 Aug 1.

Department of General Surgery, University General Hospital of Patras, Greece.

Aim To present the experience from collective data regarding patients with retroperitoneal sarcomas that have been operated in and followed up by the University General Hospital of Patras in Rion, Greece, between 2009 and 2020. Methods A retrospective analysis of adult patients treated at our hospital with a diagnosis of primary retroperitoneal sarcoma who underwent tumour resection. Results Data from 29 patients were analysed. Read More

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Ovarian carcinosarcoma is a distinct form of ovarian cancer with poorer survival compared to tubo-ovarian high-grade serous carcinoma.

Br J Cancer 2022 Jun 17. Epub 2022 Jun 17.

The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK.

Background: Ovarian carcinosarcoma (OCS) is an uncommon, biphasic and highly aggressive ovarian cancer type, which has received relatively little research attention.

Methods: We curated the largest pathologically confirmed OCS cohort to date, performing detailed histopathological characterisation, analysis of features associated with survival and comparison against high-grade serous ovarian carcinoma (HGSOC).

Results: Eighty-two OCS patients were identified; overall survival was poor (median 12. Read More

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Giant liposarcoma of lower extremity: A case report.

Asian J Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Traumatic Orthopedics, The People's Hospital of Suzhou New District, Suzhou, Jiangsu Province, 215129, China. Electronic address:

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Management of Synovial Sarcoma and Myxoid Liposarcoma.

Surg Oncol Clin N Am 2022 Jul;31(3):547-558

Department of Radiotherapy at the Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Radiotherapy at the Leiden University Medical Center, Leiden, the Netherlands.

Synovial sarcoma and myxoid liposarcoma are translocation-related sarcomas, with a high risk of developing distant metastasis, which often affect young patients and which are sensitive to chemo and radiotherapy. Surgery is the mainstay of therapy in localized disease. In these entities, perioperative radiotherapy is frequently administered, and chemotherapy is evaluated in patients with high-risk limb/trunk wall tumors in which an advantage in overall survival has been shown in the latest clinical trials. Read More

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Retroperitoneal and Mesenteric Liposarcomas.

Surg Oncol Clin N Am 2022 Jul;31(3):399-417

Department of Surgical Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, Amsterdam 1066 CX, the Netherlands. Electronic address:

Retroperitoneal liposarcomas are a rare entity and are comprised mostly of the well-differentiated and dedifferentiated subtypes. Eight-year survival ranges from 30% to 80% depending on histologic subtype and grade. Surgery is the cornerstone of treatment and compartment resection is the current standard. Read More

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Immunotherapy in Sarcoma: Where Do Things Stand?

Surg Oncol Clin N Am 2022 Jul;31(3):381-397

Department of Medical Oncology, Centre Leon Berard, 28 rue Laennec, Lyon 69008, France.

Early experiences with modern immunotherapy have been disappointing in trials of unselected sarcoma subtypes. However, remarkable efficacy has been observed with immune checkpoint inhibitors (ICIs) in a subset of patients, with the most promising outcomes to date in alveolar soft part sarcoma, cutaneous angiosarcoma, undifferentiated pleomorphic sarcoma (UPS), and dedifferentiated liposarcoma (dLPS). Adoptive cellular therapies targeting cancer testis antigens have shown promising activity, but only synovial sarcoma (SS) and myxoid/round cell liposarcomas reliably express these targets. Read More

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WHO Pathology: Highlights of the 2020 Sarcoma Update.

Surg Oncol Clin N Am 2022 Jul 31;31(3):321-340. Epub 2022 May 31.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, via Giacomo Venezian, 1, Milan 20133, Italy.

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Superficial CD34-Positive Fibroblastic Tumor: A Clinicopathologic, Immunohistochemical, and Molecular Study of 59 Cases.

Am J Surg Pathol 2022 Jun 20. Epub 2022 Jun 20.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm that shows overlapping features with PRDM10-rearranged soft tissue tumor (PRDM10-STT). This study characterizes the clinicopathologic, immunohistochemical, and molecular features of SCD34FT in a series of 59 cases. Fluorescence in situ hybridization to assess for PRDM10 rearrangement was performed in 12 tumors. Read More

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The Role of Preoperative F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Retroperitoneal Sarcoma.

Front Oncol 2022 30;12:868823. Epub 2022 May 30.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) was used to predict pathologic grades based on the maximum standardized uptake value (SUVmax) in soft tissue sarcoma and bone sarcoma. In retroperitoneal sarcoma (RPS), the effectiveness of PET was not well known. This study was designed to investigate the association of SUVmax with histopathologic grade and evaluate the usefulness of F-FDG PET/CT before operation. Read More

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Recurrent primary orbital well-differentiated liposarcoma /atypical lipomatous tumor: A rare case report with six-year follow-up.

Am J Ophthalmol Case Rep 2022 Sep 7;27:101602. Epub 2022 Jun 7.

Department of Ophthalmology. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, Dallas, USA.

Purpose: We report a case with over 6 years of follow-up for well-differentiated liposarcoma or atypical lipomatous tumor (WDL/ALT).

Observations: Over a 6-year time course, a patient with a recurrent right orbital mass was biopsied/debulked four times. It was not until the fourth biopsy that a diagnosis of WDL/ALT was obtained. Read More

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September 2022

Carbon-ion radiotherapy for urological cancers.

Int J Urol 2022 Jun 12. Epub 2022 Jun 12.

QST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.

Carbon-ions are charged particles with a high linear energy transfer, and therefore, they make a better dose distribution with greater biological effects on the tumors compared with photons and protons. Since prostate cancer, renal cell carcinoma, and retroperitoneal sarcomas such as liposarcoma and leiomyosarcoma are known to be radioresistant tumors, carbon-ion radiotherapy, which provides the advantageous radiobiological properties such as an increasing relative biological effectiveness toward the Bragg peak, a reduced oxygen enhancement ratio, and a reduced dependence on fractionation and cell-cycle stage, has been tested for these urological tumors at the National Institute for Radiological Sciences since 1994. To promote carbon-ion radiotherapy as a standard cancer therapy, the Japan Carbon-ion Radiation Oncology Study Group was established in 2015 to create a registry of all treated patients and conduct multi-institutional prospective studies in cooperation with all the Japanese institutes. Read More

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Increasing body weight of 20kg in 3 months: A case report of huge retroperitoneal liposarcoma.

Asian J Surg 2022 Jun 9. Epub 2022 Jun 9.

Department of Urology, MacKay Memorial Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

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Sarcomas in Teachers Using Three-Dimensional Printers: A Report of Three Patients and Literature Review.

Clin Orthop Surg 2022 Jun 13;14(2):310-317. Epub 2022 May 13.

Department of Orthopaedic Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: While low-cost, small-scale, desktop three-dimensional (3D) printers are gaining popularity in the education sector, some studies have reported harmful emissions of particles and volatile organic compounds during the fused deposition modeling (FDM) process, posing a potential health risk. Sarcomas are rare tumors, constituting a group of diverse rare malignant tumors. While some genetic and environmental factors contribute to the development of sarcomas, most cases are idiopathic and sporadic. Read More

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Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern.

Cancers (Basel) 2022 May 27;14(11). Epub 2022 May 27.

Unit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy.

(1) Background: This retrospective study aimed to analyze the history and treatment outcomes of localized, high-grade MLS of the extremities. (2) Methods: We retrospectively reviewed 82 patients with primary high-grade MLS of the extremities. OS, LRFS, MFS, PRS, and DFS were analyzed. Read More

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Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma.

Cancers (Basel) 2022 May 25;14(11). Epub 2022 May 25.

Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via G.A. Amadeo 42, 20133 Milan, Italy.

Background: Well-differentiated (WD)/dedifferentiated (DD) liposarcoma (LPS) accounts for ~60% of retroperitoneal sarcomas. WDLPS and DDLPS divergently evolve from a common precursor and are both marked by the amplification of the 12q13-q15 region, leading to the abnormal expression of , , and genes. DDLPS is a non-lipogenic disease associated with aggressive clinical behavior. Read More

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Can homogeneous, lipomatous tumors be primarily resected without biopsy? A retrospective analysis of 240 tumors.

World J Surg Oncol 2022 Jun 8;20(1):184. Epub 2022 Jun 8.

Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: According to guidelines, every soft tissue tumor (STT) larger than 3 cm should be biopsied before definitive resection. Advances in magnetic resonance imaging (MRI) improve the possibility to give a provisional diagnosis of the tumor's entity. Can lipomas and atypical lipomatous tumors (ALTs) of the extremities therefore be primarily marginally resected based on interpretation of MR images without a previous biopsy?. Read More

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Esophageal spindle cell lipoma.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):1051-1055

Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain;

Symptomatic ordinary esophageal lipomas are rare tumors. Spindle cell lipomas (SCLs) of this location are even more infrequent. To our knowledge, only a previous esophageal SCL case has been reported. Read More

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Myxoid pleomorphic liposarcoma is distinguished from other liposarcomas by widespread loss of heterozygosity and significantly worse overall survival: a genomic and clinicopathologic study.

Mod Pathol 2022 Jun 7. Epub 2022 Jun 7.

Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Myxoid pleomorphic liposarcoma (MPLPS) is a recently described and extremely rare subtype of liposarcoma with a predilection for the mediastinum. However, the genomic features of MPLPS remain poorly understood. We performed comprehensive genomic profiling of MPLPS in comparison with pleomorphic liposarcoma (PLPS) and myxoid/round cell liposarcoma (MRLPS). Read More

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