Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status.
- Kyoko Yamashita,
- Kenichi Kohashi,
- Yuichi Yamada,
- Yoshihiro Nishida,
- Hiroshi Urakawa,
- Yoshinao Oda,
- Shinya Toyokuni
Hum Pathol 2017 Feb 21. Epub 2017 Feb 21.
Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Extraskeletal osteosarcoma (ESOS) is an uncommon malignant neoplasm. Most ESOSs are high grade, although some low-grade cases have been reported. A few cases of ESOS with MDM2 amplification have also been reported, suggesting some similarity to skeletal low-grade osteosarcoma such as parosteal osteosarcoma, where MDM2 is often amplified. Read More