Search our Database of Scientific Publications and Authors

I’m looking for a

    6091 results match your criteria Liposarcoma

    1 OF 122

    Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status.
    Hum Pathol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
    Extraskeletal osteosarcoma (ESOS) is an uncommon malignant neoplasm. Most ESOSs are high grade, although some low-grade cases have been reported. A few cases of ESOS with MDM2 amplification have also been reported, suggesting some similarity to skeletal low-grade osteosarcoma such as parosteal osteosarcoma, where MDM2 is often amplified. Read More

    Primary liposarcoma of the diaphragm: a rare intra-abdominal mass.
    Radiol Case Rep 2017 Mar 3;12(1):136-140. Epub 2016 Dec 3.
    Department of Surgery, Columbia University, NewYork-Presbytarian/Lawrence Hospital Center, Bronxville, NY, USA.
    Primary malignant tumors of the diaphragm are rare, and primary liposarcoma of the diaphragm is extremely rare. The role of imaging is description of the anatomic relationships of the tumor as well as a suggestion of histologic diagnosis based on the presence of fatty and/or nonfatty components. Read More

    Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial.
    Eur J Cancer 2017 Feb 16;75:33-40. Epub 2017 Feb 16.
    Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.
    Background: Recent phase II and III clinical trials demonstrated anti-tumour activity of eribulin, a tubulin-interacting cytotoxic agent, in patients with metastatic soft tissue sarcoma (STS). In this exploratory study, we aimed to identify putative microRNA biomarkers that associate with eribulin sensitivity or resistance in STS.

    Materials And Methods: Archival tumour tissue from primary tumours or metastatic lesions was collected prior to eribulin treatment, from 65 consenting patients involved in the EORTC trial 62052. Read More

    Outcome of peripheral venous reconstructions during tumor resection.
    J Vasc Surg Venous Lymphat Disord 2017 Mar;5(2):185-193
    Division of Vascular Surgery, Mayo Clinic, Rochester, Minn. Electronic address:
    Objective: Peripheral venous reconstruction surgery may be necessary for appropriate oncologic resection; however, the operative approach and surgical outcomes are not well described. We report our experience with these complex reconstructions to identify best practice.

    Methods: We retrospectively reviewed all adult patients who underwent peripheral vein reconstruction for tumor resection at Mayo Clinic, Rochester (2000-2015). Read More

    Liposarcoma of the Spermatic Cord: An Infrequent Pathology.
    Case Rep Oncol 2017 Jan-Apr;10(1):136-142. Epub 2017 Jan 27.
    Pathology Department, CHU UCL, Namur, Belgium.
    Objective: To describe a rare pathology, the liposarcoma of the spermatic cord (LSC), and discuss its diagnosis and treatment.

    Materials And Methods: We report a case of well-differentiated LSC in a 61-year-old man. The main complaint was painless enlargement in the right inguinoscrotal area that appeared 6 months prior to presentation. Read More

    An Innovative Solution to Complex Inguinal Defect: Deepithelialized SIEA Flap With Mini Abdominoplasty.
    Eplasty 2017 25;17:e2. Epub 2017 Jan 25.
    Introduction: We describe a novel technique of contralateral pedicled deepithelialized superficial inferior epigastric artery flaps, followed by abdominal advancement coverage, as an alternative treatment of radiated complicated inguinal or lower abdominal defects, avoiding the donor-site defect typically seen with other methods of coverage. Methods: Two male patients with histories of liposarcoma after excision and radiation to one side of lower abdomen/inguinal area presented with complicated wounds that were reconstructed with this technique. Results: Successful obliteration of dead space and wound closure were achieved with the combination of a superficial inferior epigastric artery flap with an abdominal advancement flap. Read More

    Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology.
    Int J Surg Pathol 2017 Feb 1:1066896917693093. Epub 2017 Feb 1.
    1 Ghent University Hospital, Ghent University, Ghent, Belgium.
    A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. Read More

    PRG4 expression in myxoid liposarcoma maintains tumor cell growth through suppression of an antitumor cytokine IL-24.
    Biochem Biophys Res Commun 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pathology, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama 641-8509, Japan.
    PRG4 is one of the downstream molecules of the myxoid liposarcoma (MLS)-specific fusion oncoproteins TLS-CHOP and EWS-CHOP. Exogenous PRG4 expression increases the tumorigenicity of cells injected in nude mice. The molecular functions of PRG4 in tumorigenesis and/or tumor progression of MLS cells, however, still remain unclear. Read More

    Dedifferentiated Liposarcoma of the Esophagus: A Case Report and Selected Review of the Literature.
    Rare Tumors 2016 Nov 20;8(4):6791. Epub 2016 Dec 20.
    Departments of Oncology Radiation, Clinic Mayo , Jacksonville, FL, USA.
    Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent dedifferentiated liposarcomas. We present a case of a 75-year-old gentleman presenting with dysphagia found to have a 5 cm pedunculated mass in the cervical esophagus, originating at the cricopharyngeus. This was found to have involvement limited to the superficial mucosa by endoscopic ultrasound, and the lesion was subsequently resected endoscopically. Read More

    Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix.
    Int J Gynecol Pathol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO.
    Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare, highly lethal malignancy predominantly affecting young adult females. We report a patient with widely metastatic SCCOHT and concurrent uterine cervical pleomorphic liposarcoma. Clinical targeted next-generation sequencing was performed on both neoplasms and demonstrated hemizygous stop-gain TP53 mutations (p. Read More

    Cysteine Modifications in the Pathogenesis of ALS.
    Front Mol Neurosci 2017 23;10. Epub 2017 Jan 23.
    Fondazione Santa Lucia IRCCSRome, Italy; Department of Biology, University of Rome Tor VergataRome, Italy.
    Several proteins are found misfolded and aggregated in sporadic and genetic forms of amyotrophic lateral sclerosis (ALS). These include superoxide dismutase (SOD1), transactive response DNA-binding protein (TDP-43), fused in sarcoma/translocated in liposarcoma protein (FUS/TLS), p62, vasolin-containing protein (VCP), Ubiquilin-2 and dipeptide repeats produced by unconventional RAN-translation of the GGGGCC expansion in C9ORF72. Up to date, functional studies have not yet revealed a common mechanism for the formation of such diverse protein inclusions. Read More

    Eribulin in non-small cell lung cancer: challenges and potential strategies.
    Expert Opin Investig Drugs 2017 Feb 6. Epub 2017 Feb 6.
    b Department of Medical Oncology, Montefiore Medical Center , Albert Einstein College of Medicine , 1695 Eastchester Road, Bronx , NY 10461 , USA.
    Introduction: Eribulin is a non-taxane, macrocyclic, synthetic, ketone analog of Halichondrin B with a microtubule inhibitory action specific towards plus ends. It is approved by United States Food and Drug Administration (USFDA) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen. It is also approved as a third line therapy for patients with metastatic breast cancer who have received a prior treatment with anthracycline and taxane in either adjuvant or metastatic setting. Read More

    Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking.
    Mol Cell Neurosci 2017 Feb 1;80:32-43. Epub 2017 Feb 1.
    Section on Neurobiology, Laboratory of Molecular Biology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address:
    In previous studies, we identified a putative 38-nucleotide stem-loop structure (zipcode) in the 3' untranslated region of the cytochrome c oxidase subunit IV (COXIV) mRNA that was necessary and sufficient for the axonal localization of the message in primary superior cervical ganglion (SCG) neurons. However, little is known about the proteins that interact with the COXIV-zipcode and regulate the axonal trafficking and local translation of the COXIV message. To identify proteins involved in the axonal transport of the COXIV mRNA, we used the biotinylated 38-nucleotide COXIV RNA zipcode as bait in the affinity purification of COXIV zipcode binding proteins. Read More

    Pleomorphic myxoid liposarcoma in an adolescent with Li-Fraumeni syndrome.
    Pediatr Surg Int 2017 Feb 3. Epub 2017 Feb 3.
    Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA.
    We present the case of a 15-year-old female with a right perineal mass that was found to be pleomorphic myxoid liposarcoma, a recently recognized, rare subtype of liposarcoma. The patient had a strong family history of malignancy and genetic screening revealed a pathogenic TP53 mutation consistent with Li-Fraumeni syndrome. Read More

    Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
    PLoS One 2017 3;12(2):e0158406. Epub 2017 Feb 3.
    Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
    Purpose: The outcome of sarcoma has been suggested in retrospective and non-exhaustive studies to be better through management by a multidisciplinary team of experts and adherence to clinical practice guidelines (CPGs). The aim of this prospective and exhaustive population based study was to confirm the impact of adherence to CPGs on survival in patients with localized sarcoma.

    Experimental Design: Between 2005 and 2007, all evaluable adult patients with a newly diagnosis of localized sarcoma located in Rhone Alpes region (n = 634), including 472 cases of soft-tissue sarcoma (STS), were enrolled. Read More

    Do Mesenchymal Stem Cells Derived From Atypical Lipomatous Tumors Have Greater Differentiation Potency Than Cells From Normal Adipose Tissues?
    Clin Orthop Relat Res 2017 Feb 2. Epub 2017 Feb 2.
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13-1, Takara-machi, Kanazawa-shi, Ishikawa-ken, 920-8640, Japan.
    Background: The p53 protein in mesenchymal stem cells (MSCs) regulates differentiation to osteogenic or adipogenic lineage. Because p53 function is depressed in most malignancies, if MSCs in malignancy also have p53 hypofunction, differentiation therapy to osteogenic or adipogenic lineage may be an effective treatment. We therefore wished to begin to explore this idea by evaluating atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) cells, because murine double minute 2 (MDM2) gene amplification, which leads to p53 hypofunction, is found in almost all ALT/WDLs. Read More

    Incidence and Adverse Prognostic Implications of Histopathologic Organ Invasion in Primary Retroperitoneal Sarcoma.
    J Am Coll Surg 2017 Jan 29. Epub 2017 Jan 29.
    Department of Surgery, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA; Center for Sarcoma and Bone Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:
    Background: The incidence of histopathologic organ invasion (HOI) in retroperitoneal sarcoma (RPS) is not well described. We reviewed our experience to investigate the rate and prognostic implications of HOI.

    Study Design: Patients with primary RPS who underwent surgery at our institution were reviewed. Read More

    Lipomatous tumours in adrenal gland: WHO updates and clinical implications.
    Endocr Relat Cancer 2017 Jan 31. Epub 2017 Jan 31.
    A Lam, Pathology, Griffith University School of Medicine, Gold Coast, 4222, Australia
    Adrenal lipomatous tumour is a group of adrenal tumours with a significant component of adipose tissue. According to the current World Health Organization (WHO) classification of tumours of endocrine organs, adrenal myelolipoma is the only entity amongst the group of tumours being described. In the literature, other more recently documented adrenal lipomatous tumours included 24 lipomas, 32 teratomas and 16 angiomyolipomas. Read More

    The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities.
    Br J Cancer 2017 Jan 31. Epub 2017 Jan 31.
    Sarcoma Unit, Royal Marsden Hospital, London SW3 6JJ, UK.
    Background: EWSR1 rearrangements were first identified in Ewing sarcoma, but the spectrum of EWSR1-rearranged neoplasms now includes many soft tissue tumour subtypes including desmoplastic small round cell tumour (DSRCT), myxoid liposarcoma (MLPS), extraskeletal myxoid chondrosarcoma (EMC), angiomatoid fibrous histiocytoma (AFH), clear cell sarcoma (CCS) and myoepithelial neoplasms. We analysed the spectrum of EWSR1-rearranged soft tissue neoplasms at our tertiary sarcoma centre, by assessing ancillary molecular diagnostic modalities identifying EWSR1-rearranged tumours and reviewing the results in light of our current knowledge of these and other Ewing sarcoma-like neoplasms.

    Methods: We retrospectively analysed all specimens tested for EWSR1 rearrangements by fluorescence in situ hybridisation (FISH) and/or reverse transcription-PCR (RT-PCR) over a 7-year period. Read More

    Pharmacological therapies for Liposarcoma.
    Expert Rev Clin Pharmacol 2017 Jan 30. Epub 2017 Jan 30.
    c Department of Surgery , Fondazione IRCCS Istituto Nazionale dei Tumori , via Venezian, 1 - 20133, Milan , Italy.
    Introduction: Liposarcoma (LS) is one of the most common adult soft tissue sarcomas (STS). For metastatic disease, systemic treatment options were historically represented by standard cytotoxic chemotherapy. More recently, innovative therapies have been introduced and they are currently part of the therapeutic armamentarium, positively impacting disease control and patients' quality of life. Read More

    [A Case of Retroperitoneal Liposarcoma].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2441-2443
    Dept. of Surgery, Misawa City Hospital.
    A 52-year-old man visited a local hospital complaining of abdominal distension. Enhanced computed tomography scan revealed a giant retroperitoneal tumor surrounding the left internal iliac artery and left kidney. We performed en bloc tumor resection with left internal iliac artery resection. Read More

    [A Case of Primary Liposarcoma Arising from the Duodenum].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2359-2361
    Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center.
    We report a case of duodenal liposarcoma. A 62-year-old man presented with an abdominal tumor. Abdominal CT scan and MRI showed a tumor in the wall of the duodenum. Read More

    TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells.
    Biomed Pharmacother 2017 Jan 25;88:562-568. Epub 2017 Jan 25.
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. Electronic address:
    Background: Understanding the function of autophagy may allow us to develop a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in the treatment of cancers. Here, we studied the contribution of basal autophagy in human liposarcoma.

    Methods: The levels of basal autophagy were analyzed by measuring autophagy-related protein expression and autophagosome formation. Read More

    Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma.
    Methods Cell Biol 2017 3;138:525-561. Epub 2017 Jan 3.
    Massachusetts General Hospital, Boston, MA, United States; Massachusetts General Hospital, Charlestown, MA, United States; Harvard Stem Cell Institute, Boston, MA, United States.
    Sarcoma is a type of cancer affecting connective, supportive, or soft tissue of mesenchymal origin. Despite rare incidence in adults (<1%), over 15% of pediatric cancers are sarcoma. Sadly, both adults and children with relapsed or metastatic disease have devastatingly high rates of mortality. Read More

    A novel long noncoding RNA PILRLS promote proliferation through TCL1A by activing MDM2 in Retroperitoneal liposarcoma.
    Oncotarget 2017 Jan 25. Epub 2017 Jan 25.
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
    It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in retroperitoneal liposarcoma have never been reported. In our study, we found a novel lncRNA PILRLS (Proliferation Interacting LncRNA in Retroperitoneal Liposarcoma), which as an oncogene significantly overexpressed in retroperitoneal liposarcoma. Read More

    Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue sarcoma.
    Radiat Oncol 2017 Jan 26;12(1):29. Epub 2017 Jan 26.
    Department of General- and Visceral Surgery, Universitätsklinik Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
    Background: To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis.

    Methods: In 53 patients who underwent surgery for retroperitoneal soft tissue sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence.

    Results: Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Read More

    Incidental Presacral Myelolipoma Resembling the Liposarcoma: A Case Report and Literature Review.
    Case Rep Urol 2016 28;2016:6510930. Epub 2016 Dec 28.
    Department of Urology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
    Presacral myelolipomas are rare, benign, asymptomatic tumors composed of mature adipose tissue and hematopoietic elements, but fewer than 50 cases have been reported in the literature. They are usually discovered incidentally during imaging studies and are often misdiagnosed as liposarcoma, which have a malignant nature, because the imaging findings of myelolipoma can be similar to those of liposarcoma. It is challenging to distinguish presacral myelolipomas from other presacral fat-containing tumors without performing a histological examination. Read More

    Unusual Signal Patterns of Break-apart FISH Probes Used in the Diagnosis of Soft Tissue Sarcomas.
    Pathol Oncol Res 2017 Jan 20. Epub 2017 Jan 20.
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary.
    Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Read More

    Huge mediastinal liposarcoma resected by clamshell thoracotomy: a case report.
    Surg Case Rep 2017 Dec 20;3(1):16. Epub 2017 Jan 20.
    Department of Thoracic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
    Background: Liposarcoma is the single most common soft tissue sarcoma. Because mediastinal liposarcomas often grow rapidly and frequently recur locally despite adjuvant chemotherapy and radiotherapy, they require complete excision. Therefore, the feasibility of achieving complete surgical excision must be carefully considered. Read More

    Recent advances in the management of liposarcoma.
    F1000Res 2016 22;5:2907. Epub 2016 Dec 22.
    Hoag Family Cancer Institute, Hoag Hospital, Newport Beach, CA, USA; Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, San Pablo, Los Angeles, California, USA; USC Norris Cancer Center, Los Angeles, California, USA.
    Liposarcoma is the most common soft tissue sarcoma. With its various subtypes, the natural history of this disease can vary significantly from a locally recurrent tumor to a highly malignant one carrying a poor prognosis. Progress in the understanding of the specific molecular abnormalities in liposarcoma provides greater opportunity for new treatment modalities. Read More

    Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma.
    Oncotarget 2017 Jan 14. Epub 2017 Jan 14.
    Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
    Well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are closely related tumors commonly characterized by MDM2/CDK4 gene amplification, and lack clinically effective treatment options when inoperable. To identify novel therapeutic targets, we performed targeted genomic sequencing analysis of 19 WDLPS and 37 DDLPS tumor samples using a panel of 104 cancer-related genes (NCC oncopanel v3) developed specifically for genomic testing to select suitable molecular targeted therapies. The results of this analysis indicated that these sarcomas had very few gene mutations and a high frequency of amplifications of not only MDM2 and CDK4 but also other genes. Read More

    Giant retroperitoneal dedifferentiated liposarcoma.
    Ann Ital Chir 2017 Jan 16;6. Epub 2017 Jan 16.
    Introduction: Liposarcoma is the most frequent type of retroperitoneal sarcomas. Dedifferentiated liposarcoma is the least common subtype and is an extremely rare tumor.

    Case Report: We present the case of a 53-year-old male who was referred with a giant retroperitoneal mass. Read More

    Current Concepts in Non-Gastrointestinal Stromal Tumor Soft Tissue Sarcomas: A Primer for Radiologists.
    Korean J Radiol 2017 Jan-Feb;18(1):94-106. Epub 2017 Jan 5.
    Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
    Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist. Read More

    Paraneoplastic Cerebellar Degeneration Associated with Pelvic Liposarcoma: A Rare Case Report.
    Urol Int 2017 Jan 17. Epub 2017 Jan 17.
    Paraneoplastic cerebellar degeneration (PCD) is one of the most common paraneoplastic neurological syndromes characterized by the rapid development of severe cerebellar ataxia. In this report, a 23-year-old female with noticeable dizziness and gait instability was described. The enhanced CT scanning suggested the presence of a pelvic tumor. Read More

    Invasive Cardiac Lipoma: a case report and review of literature.
    BMC Cardiovasc Disord 2017 Jan 14;17(1):28. Epub 2017 Jan 14.
    Department of Internal Medicine, MedStar Health, 9000 Franklin square drive, Baltimore, MD, 21237, USA.
    Background: Cardiac lipomas are rare benign tumors of the heart. They are usually asymptomatic and are thus most often diagnosed on autopsies. Symptoms, when present, depend upon the location within the heart. Read More

    Can Multistate Modeling of Local Recurrence, Distant Metastasis, and Death Improve the Prediction of Outcome in Patients With Soft Tissue Sarcomas?
    Clin Orthop Relat Res 2017 Jan 12. Epub 2017 Jan 12.
    Clinical Division of Medical Oncology, Department of Medicine, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
    Background: Exploration of the complex relationship between prognostic indicators such as tumor grade and size and clinical outcomes such as local recurrence and distant metastasis in patients with cancer is crucial to guide treatment decisions. However, in patients with soft tissue sarcoma, there are many gaps in our understanding of this relationship. Multistate analysis may help us in gaining a comprehensive understanding of risk factor-outcome relationships in soft tissue sarcoma, because this methodology can integrate multiple risk factors and clinical endpoints into a single statistical model. Read More

    [Isolated limb perfusion for liposarcoma : Histopathological response and subgroup analysis after TNF melphalan-based ILP].
    Chirurg 2017 Jan 12. Epub 2017 Jan 12.
    Sektion Sarkomchirurgie, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Westdeutsches Tumorzentrum (WTZ), Hufelandstr. 55, 45147, Essen, Deutschland.
    Background: Tumor necrosis factor alpha (TNF) and melphalan-based isolated limb perfusion (TM-ILP) is one of the most effective treatment modalities for unresectable soft tissue sarcoma (STS) of the extremities. Liposarcomas (LS) are a large and heterogeneous subgroup of STS with different biological behavior and prognoses. The aim of this study was to evaluate LS and the different subentities with respect to their responsiveness towards TM-ILP. Read More

    Giant gastric lipossarcoma: case report and review of the literature.
    Einstein (Sao Paulo) 2016 Oct-Dec;14(4):557-560
    Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
    Liposarcoma is one of the most common soft tissue sarcomas in adults, occurring in 15 to 20% of all patients with sarcoma. Primary liposarcoma of the stomach is rare. We report a case of patient with giant gastric liposarcoma who underwent surgery after a gastrointestinal bleeding. Read More

    Effect of intraoperative radiotherapy in the treatment of retroperitoneal sarcoma.
    Int J Clin Oncol 2017 Jan 10. Epub 2017 Jan 10.
    Department of Surgery, Boston University School of Medicine, Boston, MA, 02118, USA.
    Background: Current National Comprehensive Cancer Network guidelines for the treatment of retroperitoneal sarcomas (RPS) endorse surgical resection, but the role of radiotherapy (RT) is less clear. We investigate the utilization and benefits of intraoperative RT (IORT) in the treatment of RPS.

    Methods: We queried the Surveillance, Epidemiology and End Results (SEER) database (1988-2013) for the utilization of IORT and perioperative external beam RT (EBRT) in patients who underwent surgical resection of RPS. Read More

    Primary retroperitoneal soft tissue sarcoma: Imaging appearances, pitfalls and diagnostic algorithm.
    Eur J Surg Oncol 2016 Dec 9. Epub 2016 Dec 9.
    Department of Surgery, Institut Curie, Paris, France.
    Although retroperitoneal sarcomas are rare tumours, they can be encountered by a wide variety of clinicians as they can be incidental findings on imaging or present with non specific symptoms and signs. Surgical resection can offer hope of cure and patient outcomes are improved when patients are managed in high-volume specialist centers. Failure to recognize retroperitoneal sarcomas on imaging can lead to inappropriate management in inexperienced centers. Read More

    Spinal cord damage after resection of destructive spinal lipoma resembling liposarcoma: case report.
    Spinal Cord Ser Cases 2016 7;2:16011. Epub 2016 Jul 7.
    Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU) , Munich, Germany.
    A 39-year-old inpatient at a tumor orthopedic department with a history of a chondrosarcoma in the scapula presented with a destructive tumorous lesion in the staging computed tomography (CT). After ambiguous results in CT-guided biopsy and an open biopsy, a surgical removal of a tumorous lesion was performed. The histological findings showed a lipoma of the spine. Read More

    Curcumin and Viscum album Extract Decrease Proliferation and Cell Viability of Soft-Tissue Sarcoma Cells: An In Vitro Analysis of Eight Cell Lines Using Real-Time Monitoring and Colorimetric Assays.
    Nutr Cancer 2017 Feb-Mar;69(2):340-351. Epub 2017 Jan 3.
    a Department of Plastic Surgery , Burn Center, Hand Center, Sarcoma Reference Center, BG-University Hospital Bergmannsheil Bochum , Bochum , Germany.
    Background: The cytostatic effects of the polyphenol curcumin and Viscum album extract (VAE) were assessed in soft-tissue sarcoma (STS) cells.

    Methods: Eight human STS cell lines were used: fibrosarcoma (HT1080), liposarcoma (SW872, T778, MLS-402), synovial sarcoma (SW982, SYO1, 1273), and malignant fibrous histiocytoma (U2197). Primary human fibroblasts served as control cells. Read More

    Resection of giant mediastinal liposarcoma via '⊣ shape' incision.
    J Surg Case Rep 2017 Jan 2;2017(1). Epub 2017 Jan 2.
    Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
    Primary mediastinal liposarcomas are extremely rare conditions often resected through standard median sternotomy or lateral thoracotomy. However, the management of a very huge mediastinal tumor involving hemithorax through these two common surgical approaches is always challenging. Herein, we report a case of applying median sternotomy with a sternum transection plus a right fourth intercostal thoracotomy ('⊣ shape' incision) to resect a giant primary anterior mediastinal liposarcoma extending into the whole right thorax. Read More

    Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis.
    Oncotarget 2017 Jan;8(4):6896-6913
    Department of Biochemistry and Molecular Biology, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, Greece.
    Liposarcoma (LPS) is a malignancy with extreme heterogeneity and thus optimization towards personalizing patient prognosis and treatment is essential. Here, we evaluated miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in LPS, as novel FFPE tissue biomarkers.A total of 83 FFPE tissue specimens from primary LPS and lipomas (LPM) were analyzed. Read More

    Esophageal liposarcoma: Well-differentiated rhabdomyomatous type.
    World J Gastrointest Oncol 2016 Dec;8(12):835-839
    Hisham M Valiuddin, Lake Erie College of Osteopathic Medicine Bradenton, Bradenton, FL 34211, United States.
    Rhabdomyomatous well-differentiated esophageal liposarcomas are extremely rare. As of August 2016, only one other such case has been reported in the English-language medical literature. Liposarcomas in general are one of the most common soft tissue neoplasms in adults, but the incidence of primary esophageal liposarcomas is exceptionally low. Read More

    Myxoid liposarcoma of the hand - A rare entity.
    J Clin Orthop Trauma 2016 Oct-Dec;7(Suppl 1):65-68. Epub 2016 Jul 25.
    Department of Orthopedic Surgery, Trauma Center, Ben Arous, Tunisia.
    Hand liposarcomas are not well recognized in common practice, which leads to erroneous diagnostics and delayed proper treatment. We reported a case of a myxoid liposarcoma classified as stage IIb, and developed in the palmar side of the left hand in a 38-year-old man. There was an initial tumor reduction by a sclerosing agent injection that proved to be a failure. Read More

    Retroperitoneal liposarcoma excreting insulin-like growth factor 2 that induced severe hypoglycemia.
    Int J Urol 2017 Feb 24;24(2):162-165. Epub 2016 Dec 24.
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan.
    Insulin-like growth factor 2 is overexpressed in various cancers, and is associated with a poor prognosis. Also, it is known that insulin-like growth factor 2 is an etiology of non-islet cell tumor hypoglycemia. In this report, we describe a case of unexpected hypoglycemia caused by a dedifferentiated liposarcoma producing insulin-like growth factor 2. Read More

    Spermatic cord dedifferentiated liposarcoma presenting as a recurrent inguinal hernia.
    Can J Urol 2016 Dec;23(6):8581-8584
    Division of Urology, West Virginia University, Morgantown, West Virginia, USA.
    Paratesticular sarcomas are a rare entity and provide a unique clinical challenge due to their slow growing, often painless natural course. Adding to this challenge is the complex anatomy of the scrotum that allows these masses to mimic other conditions, including inguinal hernia, cysts, or fluid collections. We report such a case and our approach to an 83-year-old male with dedifferentiated liposarcoma of the spermatic cord with a history of inguinal hernia. Read More

    1 OF 122