155 results match your criteria Lipodystrophy Localized

[A hollow on the thighs].

Rev Med Interne 2021 Jul 14;42(7):515-516. Epub 2021 Jan 14.

Service de dermatologie, hôpital Hédi Chaker, route El Ain, km 0,5, 3029 Sfax, Tunisie.

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Insulin-induced Lipoatrophy in a Patient on Insulin Analogue Therapy: a Case Report.

Folia Med (Plovdiv) 2020 Sep;62(3):597-600

Medical University of Plovdiv, Plovdiv, Bulgaria.

Insulin-induced lipoatrophy is a rare skin complication in patients with diabetes mellitus. It is characterized primarily by localized subcutaneous atrophy of the fatty tissue at the site of frequent insulin injection. We report a clinical case of a 38-year-old woman with lipoatrophy, developed during treatment with insulin analogues. Read More

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September 2020

Whipple disease diagnosed by enteroscopy: first case report in Colombia of an underdiagnosed disease and literature review.

BMC Gastroenterol 2020 Jun 23;20(1):197. Epub 2020 Jun 23.

Gastroenterology and Hepatology Department, Digestive Endoscopy Section, Fundación Santa Fe de Bogotá and Universidad de los Andes Medical School, Bogotá D.C., Colombia.

Background: Whipple's disease is a rare systemic disease caused by a gram-positive bacillus called Tropheryma whipplei. First described in 1907 as an intestinal lipodystrophy with histological finding of vacuoles in the macrophages of the intestinal mucous. Usually the symptoms are localized according to the compromised organ. Read More

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Persistent postvaccinal nodules with localized involutional lipoatrophy in a young child.

Int J Dermatol 2020 Sep 9;59(9):e327-e328. Epub 2020 Jun 9.

Department of Dermatology, Saint-Eloi Hospital, University of Montpellier, Montpellier, France.

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September 2020

A Rare Case of Checkerboard-Like Becker Nevi with a Unique Distribution of Abnormalities.

Case Rep Dermatol Med 2019 14;2019:2387365. Epub 2019 May 14.

Division of Dermatology, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Becker nevus syndrome refers to a rare disorder comprising the typical pigmented lesion and its associated developmental abnormalities. Becker nevus itself is typically localized on the upper trunk, scapular or upper arm unilaterally; however, it can occasionally occur as multiple or bilateral lesions on any parts of the body. In this report, a rare case of multiple Becker nevi arranged in a unique checkerboard-like pattern is presented. Read More

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Linear lipoatrophy following intra-articular triamcinolone acetonide injection mimicking linear scleroderma.

Pediatr Dermatol 2019 Jan 28;36(1):e56-e57. Epub 2018 Nov 28.

Division of Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.

A 12-year-old female with oligoarticular juvenile inflammatory arthritis developed an atrophic linear plaque involving the left medial forearm and proximal arm 7 months after intra-articular triamcinolone injection for arthritis. The plaque spontaneously resolved without treatment over approximately one year. It is important to recognize this rare complication of intra-articular steroid injection in order to avoid potential misdiagnosis as linear scleroderma and subsequent immunosuppressive treatment. Read More

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January 2019

Multiple Symmetric Lipomatosis (Madelung Disease) in a Large Canadian Family With the Mitochondrial c.8344A>G Variant.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618802867. Epub 2018 Sep 29.

Western University, London, Ontario, Canada.

Multiple symmetric lipomatosis (MSL), also known as Madelung disease, is a rare adult-onset disorder characterized by benign lipomatosis usually localized to the nuchal and upper thoracic region. A subset of these patients has germline variants in mitochondrial DNA. Three siblings of Northern European descent with MSL were assessed initially and provided whole blood for DNA analysis. Read More

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September 2018

Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy.

Front Immunol 2018 19;9:2142. Epub 2018 Sep 19.

La Paz University Hospital Research Institute, Madrid, Spain.

Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia. Diagnosis of AGL is based on the observation of generalized fat loss, autoimmunity and lack of family history of lipodystrophy. The pathogenic mechanism of fat destruction remains unknown but evidences suggest an autoimmune origin. Read More

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September 2019

Tropheryma whipplei Infection (Whipple Disease) in the USA.

Dig Dis Sci 2019 01 23;64(1):213-223. Epub 2018 Mar 23.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA.

Background: Whipple disease (WD) is an infection caused by the bacterium Tropheryma whipplei (TW). Few cases have been reported in the USA.

Aims: To report on the demographics, clinical manifestations, diagnostic findings, treatment, and outcomes of TW infection. Read More

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January 2019

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.

Sci Rep 2017 12 14;7(1):17593. Epub 2017 Dec 14.

The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.

Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis. The ARL15 gene encodes a small GTP-binding protein whose function is currently unknown. In this study adipocyte-autonomous roles for ARL15 were investigated using conditional knockdown of Arl15 in murine 3T3-L1 (pre)adipocytes. Read More

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December 2017

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing.

Ageing Res Rev 2018 Mar 5;42:1-13. Epub 2017 Dec 5.

CNR Institute of Molecular Genetics, Unit of Bologna, Via di Barbiano 1/10, I-40136, Bologna, Italy; Rizzoli Orthopedic Institute, Via di Barbiano 1/10, I-40136, Bologna, Italy. Electronic address:

Mandibuloacral dysplasia (MAD) is a rare genetic condition characterized by bone abnormalities including localized osteolysis and generalized osteoporosis, skin pigmentation, lipodystrophic signs and mildly accelerated ageing. The molecular defects associated with MAD are mutations in LMNA or ZMPSTE24 (FACE1) gene, causing type A or type B MAD, respectively. Downstream of LMNA or ZMPSTE24 mutations, the lamin A precursor, prelamin A, is accumulated in cells and affects chromatin dynamics and stress response. Read More

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Localized Lipodystrophy following Single Dose Intramuscular Gentamycin Injection.

Indian Dermatol Online J 2017 Sep-Oct;8(5):373-374

Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India.

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October 2017

Insulin Injection Site Adverse Effect in a Type 1 Diabetes Patient: An Unusual Presentation.

J Clin Diagn Res 2017 Aug 1;11(8):OD10-OD11. Epub 2017 Aug 1.

Diabetes Educator and Medical Social Worker, Diabetes Unit, KEM Hospitals, Pune, Maharashtra, India.

Insulin is an integral part of Type 1 diabetes management. Patient education is of utmost importance to ensure proper injection technique for getting appropriate glycaemic control as well as to avoid injection site adverse effects. Commonest injection site adverse effect is lipodystrophy, attributable to localized manifestation of the pharmacological action of insulin. Read More

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Wiedemann-Rautenstrauch syndrome: A phenotype analysis.

Am J Med Genet A 2017 Jul 26;173(7):1763-1772. Epub 2017 Apr 26.

Department of Pediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Wiedemann-Rautenstrauch syndrome (WRS) is a neonatal progeroid disorder characterized by growth retardation, lipodystrophy, a distinctive face, and dental anomalies. Patients reported to date demonstrate a remarkable variability in phenotype, which hampers diagnostics. We performed a literature search, and analyzed 51 reported patients, using the originally reported patients as "gold standard. Read More

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Lipodystrophy Syndromes.

Endocrinol Metab Clin North Am 2016 12 6;45(4):783-797. Epub 2016 Oct 6.

Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8537, USA. Electronic address:

Lipodystrophies are heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. They are subclassified depending on degree of fat loss and whether the disorder is genetic or acquired. The two most common genetic varieties include congenital generalized lipodystrophy and familial partial lipodystrophy; the two most common acquired varieties include acquired generalized lipodystrophy and acquired partial lipodystrophy. Read More

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December 2016

Localized involutional lipoatrophy at the site of an influenza vaccination: A case report.

J Dermatol 2017 Apr 11;44(4):e66-e67. Epub 2016 Oct 11.

Department of Dermatology, Osaka Medical College, Takatsuki, Japan.

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Effectiveness of carboxytherapy in the treatment of cellulite in healthy women: a pilot study.

Clin Cosmet Investig Dermatol 2016 22;9:183-90. Epub 2016 Aug 22.

Federal University of São Carlos (UFSCAR); University of São Paulo (USP), São Carlos; Indústria Brasileira de Equipamentos Médicos (IBRAMED), Amparo, São Paulo, Brazil.

Background: Carbon dioxide therapy, better known as carboxytherapy, relates to percutaneous infusion of medical carbon dioxide with therapeutic approaches, and its use in the treatment of localized fat has demonstrated good results. Gynoid lipodystrophy, also known as cellulite, affects 80%-90% of women after puberty, especially in the buttocks and thighs. Its etiology is complex and involves multifactorial aspects. Read More

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Lipedema: diagnostic and management challenges.

Int J Womens Health 2016 11;8:389-95. Epub 2016 Aug 11.

Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital, Basel, Switzerland.

Lipedema is an uncommon disorder characterized by localized adiposity of the lower extremities, often occurring in females with a family history of the condition. The adiposity extends from hips to ankles and is typically unresponsive to weight loss. In addition to the aesthetic deformity, women also describe pain in the lower extremities, particularly with pressure, as well as easy bruising. Read More

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A Case Of Bilateral Acquired Localized Lipoatrophy.

Case Rep Dermatol 2016 May-Aug;8(2):185-8. Epub 2016 Jul 11.

Department of Dermatology, Harran University School of Medicine, Şanliurfa, Turkey.

Lipoatrophy is characterized by inflammation and tissue loss in fatty tissue. This disease may be congenital or acquired, primary or secondary. Secondary lipoatrophy develops with infections, collagen tissue diseases, tumors and drug injections. Read More

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Lipoatrophia semicircularis: a case report and review of the literature.

G Ital Dermatol Venereol 2016 Aug;151(4):441-4

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy -

The case of a 45 years old woman with lipoatrophia semicircularis is presented showing a typical semicircular depressions of the anterolateral aspects of the thighs. The lesion regressed after avoiding the pressing of the thighs against the desk edge. A PubMed search disclosed 125 cases of lipoatrophia semicircularis reported in details. Read More

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Localized Lipoatrophy in a Boy After an Intramuscular Injection of Penicillin.

Actas Dermosifiliogr 2016 Sep 2;107(7):620-2. Epub 2016 Mar 2.

Departamento de Dermatología, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, España.

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September 2016

Arabidopsis SEIPIN Proteins Modulate Triacylglycerol Accumulation and Influence Lipid Droplet Proliferation.

Plant Cell 2015 Sep 11;27(9):2616-36. Epub 2015 Sep 11.

Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, Texas 76203

The lipodystrophy protein SEIPIN is important for lipid droplet (LD) biogenesis in human and yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three SEIPIN homologs in Arabidopsis thaliana, designated SEIPIN1, SEIPIN2, and SEIPIN3. Essentially nothing is known about the functions of SEIPIN homologs in plants. Read More

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September 2015

Paradoxical adipose hyperplasia secondary to cryolipolysis: An underreported entity?

Lasers Surg Med 2015 Aug 19;47(6):476-8. Epub 2015 Jun 19.

Department of Dermatology, The University of Texas Health Science Center at Houston, Houston, Texas.

Background And Objective: Cryolipolysis is a non-invasive, safe, and effective treatment for localized fat reduction. Paradoxical adipose hyperplasia (PAH) is a rare adverse effect in which patients develop painless, firm, and well-demarcated tissue masses in the treatment areas approximately 3-6 months following cryolipolysis. The incidence of PAH has been estimated at 0. Read More

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Electrolyte and Haemogram changes post large volume liposuction comparing two different tumescent solutions.

Indian J Plast Surg 2014 Sep-Dec;47(3):386-93

Department of Plastic Surgery, Sir Ganga Ram Hospital, New Delhi, India.

Background: The most common definitions of large volume liposuction refer to total 5 l volume aspiration during a single procedure (fat plus wetting solution). Profound haemodynamic and metabolic alterations can accompany large volume liposuction. Due to paucity of literature on the effect of different tumescent solutions on the electrolyte balance and haematological changes during large volume liposuction, we carried out this study using two different wetting solutions to study the same. Read More

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January 2015

Insulin-induced localized lipoatrophy preceded by shingles (herpes zoster): a case report.

J Med Case Rep 2014 Jun 24;8:223. Epub 2014 Jun 24.

Practice of Endocrinology and Diabetology, PD Dr, Kimmerle, Aachener Strasse 196, 40223 Düsseldorf, Germany.

Introduction: Localized involutional lipoatrophy of subcutaneous adipose tissue may develop due to subcutaneous injection of pharmaceutical preparations. The pathogenesis of this adverse drug reaction is unknown. The progression of localized involutional lipoatrophy ceases and occasionally it resolves after withdrawing the inducing agent. Read More

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Implantation of autologous fat globules in localized scleroderma and idiopathic lipoatrophy--report of five patients.

An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):120-3

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, CampinasSP, Brazil.

A large number of diseases may cause Atrophic skin disorders are caused by a large number of diseases, some of them idiopathic and others inflammatory, in which there is loss of volume of body segments. Localized scleroderma is a rare inflammatory dermatosis, manifested by atrophic skin and subcutaneous tissue alterations. Lipoatrophy may be genetically inherited or acquired as a result of panniculitis, HIV infections or aging. Read More

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Insulin-induced localized lipoatrophy.

Acta Dermatovenerol Alp Pannonica Adriat 2013 Dec;22(4):83-5

Department of Dermatology, University Medical Centre Maribor, Slovenia. Department of Dermatology, Medical Faculty, University of Maribor, Slovenia. Department of Pathology, Medical Faculty, University of Ljubljana, Slovenia. Corresponding author:

Insulin lipoatrophy is a rare immunologic cutaneous complication in diabetes mellitus that presents with localized subcutaneous fat atrophy at the insulin injection site. We report the case of a 62-year-old woman with type 2 diabetes mellitus that developed localized lipoatrophy on the abdomen after 6 years of therapy with the insulin analogues detemir and aspart. Read More

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December 2013

Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.

Tom Nolis

J Hum Genet 2014 Jan 24;59(1):16-23. Epub 2013 Oct 24.

Graduate Entry Medical School, Richmond Hill, Ontario, Canada.

Lipodystrophies are an immense group of genetic or acquired metabolic disorders that are characterized by varying degrees of body fat loss and in some instances localized accumulation of subcutaneous fat. Lipodystrophies are often tightly linked with profound metabolic complications; this strong bond emphasizes and reinforces the significance of adipose tissue as a dynamic endocrine organ. The extent of fat loss determines the severity of associated metabolic complications such as diabetes mellitus, hypertriglyceridemia and hepatic steatosis. Read More

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January 2014

Diphlorethohydroxycarmalol of Ishige okamurae and Caffeine Modified the Expression of Extracellular Fibrillars during Adipogenesis of Mouse Subcutaneous Adipose Derived Stem Cell.

Dev Reprod 2013 Sep;17(3):275-87

Division of Developmental Biology and Physiology, School of Biosicences and Chemistry, Sungshin Women's University, Seoul 142-742, Republic of Korea.

Although, one of the etiologies of localized lipodystrophy of the subcutaneous connective tissue (cellulite) is the histological alternation of adipose tissue, the characteristics of expression of the components of extracellular matrix (ECM) components during adipogenesis are not uncovered. In this study, the effects of caffeine and Ishige okamurae originated diphlorethohydroxycarmalol (DPHC) on the expression of extracellualr fibers was analyzed with quantitative RT-PCR during differentiation induction of mouse subcutaneous adipose derived stem cells (msADSC) into adipocyte. The expression levels of Col1a, Col3a1, and Col61a were decreased by the adipogenci induction in a time-dependent manners. Read More

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September 2013