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    143 results match your criteria Lipodystrophy Localized

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    Tropheryma whipplei Infection (Whipple Disease) in the USA.
    Dig Dis Sci 2018 Mar 23. Epub 2018 Mar 23.
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA.
    Background: Whipple disease (WD) is an infection caused by the bacterium Tropheryma whipplei (TW). Few cases have been reported in the USA.

    Aims: To report on the demographics, clinical manifestations, diagnostic findings, treatment, and outcomes of TW infection. Read More

    The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
    Sci Rep 2017 Dec 14;7(1):17593. Epub 2017 Dec 14.
    The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.
    Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis. The ARL15 gene encodes a small GTP-binding protein whose function is currently unknown. In this study adipocyte-autonomous roles for ARL15 were investigated using conditional knockdown of Arl15 in murine 3T3-L1 (pre)adipocytes. Read More

    Insulin Injection Site Adverse Effect in a Type 1 Diabetes Patient: An Unusual Presentation.
    J Clin Diagn Res 2017 Aug 1;11(8):OD10-OD11. Epub 2017 Aug 1.
    Diabetes Educator and Medical Social Worker, Diabetes Unit, KEM Hospitals, Pune, Maharashtra, India.
    Insulin is an integral part of Type 1 diabetes management. Patient education is of utmost importance to ensure proper injection technique for getting appropriate glycaemic control as well as to avoid injection site adverse effects. Commonest injection site adverse effect is lipodystrophy, attributable to localized manifestation of the pharmacological action of insulin. Read More

    Wiedemann-Rautenstrauch syndrome: A phenotype analysis.
    Am J Med Genet A 2017 Apr 26. Epub 2017 Apr 26.
    Department of Pediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Wiedemann-Rautenstrauch syndrome (WRS) is a neonatal progeroid disorder characterized by growth retardation, lipodystrophy, a distinctive face, and dental anomalies. Patients reported to date demonstrate a remarkable variability in phenotype, which hampers diagnostics. We performed a literature search, and analyzed 51 reported patients, using the originally reported patients as "gold standard. Read More

    Lipodystrophy Syndromes.
    Endocrinol Metab Clin North Am 2016 Dec 6;45(4):783-797. Epub 2016 Oct 6.
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8537, USA. Electronic address:
    Lipodystrophies are heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. They are subclassified depending on degree of fat loss and whether the disorder is genetic or acquired. The two most common genetic varieties include congenital generalized lipodystrophy and familial partial lipodystrophy; the two most common acquired varieties include acquired generalized lipodystrophy and acquired partial lipodystrophy. Read More

    Effectiveness of carboxytherapy in the treatment of cellulite in healthy women: a pilot study.
    Clin Cosmet Investig Dermatol 2016 22;9:183-90. Epub 2016 Aug 22.
    Federal University of São Carlos (UFSCAR); University of São Paulo (USP), São Carlos; Indústria Brasileira de Equipamentos Médicos (IBRAMED), Amparo, São Paulo, Brazil.
    Background: Carbon dioxide therapy, better known as carboxytherapy, relates to percutaneous infusion of medical carbon dioxide with therapeutic approaches, and its use in the treatment of localized fat has demonstrated good results. Gynoid lipodystrophy, also known as cellulite, affects 80%-90% of women after puberty, especially in the buttocks and thighs. Its etiology is complex and involves multifactorial aspects. Read More

    Lipedema: diagnostic and management challenges.
    Int J Womens Health 2016 11;8:389-95. Epub 2016 Aug 11.
    Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital, Basel, Switzerland.
    Lipedema is an uncommon disorder characterized by localized adiposity of the lower extremities, often occurring in females with a family history of the condition. The adiposity extends from hips to ankles and is typically unresponsive to weight loss. In addition to the aesthetic deformity, women also describe pain in the lower extremities, particularly with pressure, as well as easy bruising. Read More

    A Case Of Bilateral Acquired Localized Lipoatrophy.
    Case Rep Dermatol 2016 May-Aug;8(2):185-8. Epub 2016 Jul 11.
    Department of Dermatology, Harran University School of Medicine, Şanliurfa, Turkey.
    Lipoatrophy is characterized by inflammation and tissue loss in fatty tissue. This disease may be congenital or acquired, primary or secondary. Secondary lipoatrophy develops with infections, collagen tissue diseases, tumors and drug injections. Read More

    Lipoatrophia semicircularis: a case report and review of the literature.
    G Ital Dermatol Venereol 2016 Aug;151(4):441-4
    Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy -
    The case of a 45 years old woman with lipoatrophia semicircularis is presented showing a typical semicircular depressions of the anterolateral aspects of the thighs. The lesion regressed after avoiding the pressing of the thighs against the desk edge. A PubMed search disclosed 125 cases of lipoatrophia semicircularis reported in details. Read More

    Arabidopsis SEIPIN Proteins Modulate Triacylglycerol Accumulation and Influence Lipid Droplet Proliferation.
    Plant Cell 2015 Sep 11;27(9):2616-36. Epub 2015 Sep 11.
    Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, Texas 76203
    The lipodystrophy protein SEIPIN is important for lipid droplet (LD) biogenesis in human and yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three SEIPIN homologs in Arabidopsis thaliana, designated SEIPIN1, SEIPIN2, and SEIPIN3. Essentially nothing is known about the functions of SEIPIN homologs in plants. Read More

    Paradoxical adipose hyperplasia secondary to cryolipolysis: An underreported entity?
    Lasers Surg Med 2015 Aug 19;47(6):476-8. Epub 2015 Jun 19.
    Department of Dermatology, The University of Texas Health Science Center at Houston, Houston, Texas.
    Background And Objective: Cryolipolysis is a non-invasive, safe, and effective treatment for localized fat reduction. Paradoxical adipose hyperplasia (PAH) is a rare adverse effect in which patients develop painless, firm, and well-demarcated tissue masses in the treatment areas approximately 3-6 months following cryolipolysis. The incidence of PAH has been estimated at 0. Read More

    Electrolyte and Haemogram changes post large volume liposuction comparing two different tumescent solutions.
    Indian J Plast Surg 2014 Sep-Dec;47(3):386-93
    Department of Plastic Surgery, Sir Ganga Ram Hospital, New Delhi, India.
    Background: The most common definitions of large volume liposuction refer to total 5 l volume aspiration during a single procedure (fat plus wetting solution). Profound haemodynamic and metabolic alterations can accompany large volume liposuction. Due to paucity of literature on the effect of different tumescent solutions on the electrolyte balance and haematological changes during large volume liposuction, we carried out this study using two different wetting solutions to study the same. Read More

    Insulin-induced localized lipoatrophy preceded by shingles (herpes zoster): a case report.
    J Med Case Rep 2014 Jun 24;8:223. Epub 2014 Jun 24.
    Practice of Endocrinology and Diabetology, PD Dr, Kimmerle, Aachener Strasse 196, 40223 Düsseldorf, Germany.
    Introduction: Localized involutional lipoatrophy of subcutaneous adipose tissue may develop due to subcutaneous injection of pharmaceutical preparations. The pathogenesis of this adverse drug reaction is unknown. The progression of localized involutional lipoatrophy ceases and occasionally it resolves after withdrawing the inducing agent. Read More

    Implantation of autologous fat globules in localized scleroderma and idiopathic lipoatrophy--report of five patients.
    An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):120-3
    Universidade Estadual de Campinas, Faculdade de Ciências Médicas, CampinasSP, Brazil.
    A large number of diseases may cause Atrophic skin disorders are caused by a large number of diseases, some of them idiopathic and others inflammatory, in which there is loss of volume of body segments. Localized scleroderma is a rare inflammatory dermatosis, manifested by atrophic skin and subcutaneous tissue alterations. Lipoatrophy may be genetically inherited or acquired as a result of panniculitis, HIV infections or aging. Read More

    Insulin-induced localized lipoatrophy.
    Acta Dermatovenerol Alp Pannonica Adriat 2013 Dec;22(4):83-5
    Department of Dermatology, University Medical Centre Maribor, Slovenia. Department of Dermatology, Medical Faculty, University of Maribor, Slovenia. Department of Pathology, Medical Faculty, University of Ljubljana, Slovenia. Corresponding author:
    Insulin lipoatrophy is a rare immunologic cutaneous complication in diabetes mellitus that presents with localized subcutaneous fat atrophy at the insulin injection site. We report the case of a 62-year-old woman with type 2 diabetes mellitus that developed localized lipoatrophy on the abdomen after 6 years of therapy with the insulin analogues detemir and aspart. Read More

    Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.
    J Hum Genet 2014 Jan 24;59(1):16-23. Epub 2013 Oct 24.
    Graduate Entry Medical School, Richmond Hill, Ontario, Canada.
    Lipodystrophies are an immense group of genetic or acquired metabolic disorders that are characterized by varying degrees of body fat loss and in some instances localized accumulation of subcutaneous fat. Lipodystrophies are often tightly linked with profound metabolic complications; this strong bond emphasizes and reinforces the significance of adipose tissue as a dynamic endocrine organ. The extent of fat loss determines the severity of associated metabolic complications such as diabetes mellitus, hypertriglyceridemia and hepatic steatosis. Read More

    Diphlorethohydroxycarmalol of Ishige okamurae and Caffeine Modified the Expression of Extracellular Fibrillars during Adipogenesis of Mouse Subcutaneous Adipose Derived Stem Cell.
    Dev Reprod 2013 Sep;17(3):275-87
    Division of Developmental Biology and Physiology, School of Biosicences and Chemistry, Sungshin Women's University, Seoul 142-742, Republic of Korea.
    Although, one of the etiologies of localized lipodystrophy of the subcutaneous connective tissue (cellulite) is the histological alternation of adipose tissue, the characteristics of expression of the components of extracellular matrix (ECM) components during adipogenesis are not uncovered. In this study, the effects of caffeine and Ishige okamurae originated diphlorethohydroxycarmalol (DPHC) on the expression of extracellualr fibers was analyzed with quantitative RT-PCR during differentiation induction of mouse subcutaneous adipose derived stem cells (msADSC) into adipocyte. The expression levels of Col1a, Col3a1, and Col61a were decreased by the adipogenci induction in a time-dependent manners. Read More

    Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction.
    Arterioscler Thromb Vasc Biol 2013 Sep 11;33(9):2162-71. Epub 2013 Jul 11.
    UPMC Univ Paris 06, UMR_S938, Paris, France.
    Objective: Some mutations in LMNA, encoding A-type lamins, are responsible for Dunnigan-type-familial partial lipodystrophy (FPLD2), with altered fat distribution and metabolism. The high prevalence of early and severe cardiovascular outcomes in these patients suggests that, in addition to metabolic risk factors, FPLD2-associated LMNA mutations could have a direct role on the vascular wall cells.

    Approach And Results: We analyzed the cardiovascular phenotype of 19 FPLD2 patients aged >30 years with LMNA p. Read More

    Cardiac steatosis and left ventricular hypertrophy in patients with generalized lipodystrophy as determined by magnetic resonance spectroscopy and imaging.
    Am J Cardiol 2013 Oct 22;112(7):1019-24. Epub 2013 Jun 22.
    The Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
    Generalized lipodystrophy is a rare disorder characterized by marked loss of adipose tissue with reduced triglyceride storage capacity, leading to a severe form of metabolic syndrome including hypertriglyceridemia, insulin resistance, type 2 diabetes mellitus, and hepatic steatosis. Recent echocardiographic studies suggest that concentric left ventricular (LV) hypertrophy is another characteristic feature of this syndrome, but the mechanism remains unknown. It has recently been hypothesized that the LV hypertrophy could be an extreme clinical example of "lipotoxic cardiomyopathy": excessive myocyte accumulation of triglyceride leading to adverse hypertrophic signaling. Read More

    A Patient with Congenital Generalized Lipodystrophy Due To a Novel Mutation in BSCL2: Indications for Secondary Mitochondrial Dysfunction.
    JIMD Rep 2012 4;4:47-54. Epub 2011 Nov 4.
    Department of Metabolic Diseases, UMC Utrecht, Room KE.03.139.2, Lundlaan 6, 3584 EA, Utrecht, The Netherlands.
    Background: Congenital generalized lipodystrophy (CGL) results from mutations in AGPAT2, encoding 1-acyl-glycerol-3-phosphate-acyltransferase 2 (CGL1; MIM 608594), BSCL2, encoding seipin (CGL2; MIM 269700), CAV1, encoding caveolin1 (CGL3; MIM 612526) or PTRF, encoding polymerase I and transcript release factor (CGL4; MIM 613327). This study aims to investigate the genotype/phenotype relationship and search for a possible pathogenic mechanism in a patient with CGL.

    Design: Case report. Read More

    Focal congenital lipoatrophy and vascular malformation: a mild form of inverse Klippel-Trenaunay syndrome?
    Eur J Med Genet 2012 Dec 31;55(12):705-7. Epub 2012 Aug 31.
    Department of Pediatrics, Federico II University of Naples, Via Pansini, 5, 80131 Naples, Italy.
    A 2 year-and seven month-old male boy with vascular malformation and localized soft tissue hypotrophy is reported. Such presentation could represent the mildest end of the spectrum of 'inverse' Klippel-Trenaunay syndrome, a recently proposed disorder presenting with tissue hypotrophy as opposed to partial or complete limb overgrowth of classic Klippel-Trenaunay syndrome. Read More

    Lipodystrophia centrifugalis abdominalis infantilis: statistical analysis of 168 cases.
    Pediatr Dermatol 2012 Jul-Aug;29(4):437-41. Epub 2011 Dec 30.
    Department of Dermatology, Jujo Rehabilitation Hospital, Kyoto, Japan.
    Lipodystrophia centrifugalis abdominalis infantilis is a localized lipodystrophic disease affecting young children. A total of 168 cases were collected from dermatology literature. Where possible, details of the data were also obtained from the authors. Read More

    Clinical review#: Lipodystrophies: genetic and acquired body fat disorders.
    J Clin Endocrinol Metab 2011 Nov 24;96(11):3313-25. Epub 2011 Aug 24.
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8537, USA.
    Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by selective loss of body fat and predisposition to insulin resistance. The extent of fat loss determines the severity of associated metabolic complications such as diabetes mellitus, hypertriglyceridemia, and hepatic steatosis.

    Evidence Acquisition And Synthesis: Both original and review articles were found via PubMed search reporting on clinical features and management of various types of lipodystrophies and were integrated with the author's knowledge of the field. Read More

    [Lipin 1 in lipid metabolism].
    Yakugaku Zasshi 2011 ;131(8):1189-94
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
    The gene encoding lipin 1 was identified with a positional cloning approach that localized the causative mutation in fatty liver dystrophic (fld) mice, a mouse model of lipodystrophy. The fld mouse lacks normal adipose tissue in the body, and displays metabolic dysregulation such as obesity, insulin resistance, and hypertriglyceridemia. Lipin 1 is abundantly expressed in key metabolic tissues, including adipose tissue, skeletal muscle, and liver. Read More

    Disorders of fat partitioning in treated HIV-infection.
    Best Pract Res Clin Endocrinol Metab 2011 Jun;25(3):415-27
    Infectious Diseases Unit, Hospital Clínic-Institut d'Investigaciones Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
    HIV-associated lipodystrophy is clinically characterized by body fat changes including subcutaneous fat loss (lipoatrophy) with or without truncal fat accumulation (lipohypertrophy). Thymidine nucleoside reverse transcriptase inhibitors, stavudine and to a lesser extent zidovudine, are major contributors for lipoatrophy. Drug factors are not clear for lipohypertrophy. Read More

    Polyacrylamide gel for facial wasting rehabilitation: how many milliliters per session?
    Aesthetic Plast Surg 2012 Feb 3;36(1):174-9. Epub 2011 Jun 3.
    Centro Polispecialistico Santa Apollonia, Via Martiri del Dissenso, 47, 81055, S. Maria C. V., CE, Italy.
    Background: Facial lipoatrophy is most distressing for HIV patients in pharmacologic treatment. Nonabsorbable fillers are widely used to restore facial features in these patients. We evaluated the safety and aesthetic outcomes of two samples of HIV+ patients affected by facial wasting who received different filling protocols of the nonabsorbable filler Aquamid® to restore facial wasting. Read More

    Pan-insulin allergy and severe lipoatrophy complicating Type 2 diabetes.
    Diabet Med 2011 Apr;28(4):500-3
    Department of Diabetes and Endocrinology, The Hillingdon Hospital, Uxbridge, UK.
    Background:   Insulin allergy is a rare complication of insulin use. Localized lipoatrophy is also known to occur following subcutaneous injections of insulin.

    Case Report:   A 53-year-old non-obese female patient with Type 2 diabetes displayed local allergic-type symptoms to all available insulin preparations. Read More

    Severe localized lipoatrophy related to therapy with insulin analogs in type 1a diabetes mellitus.
    Diabetes Res Clin Pract 2011 Mar 13;91(3):e61-3. Epub 2010 Dec 13.
    Servicio de Endocrinoloxía e Nutrición, Complexo Hospitalario Universitario de Santiago de Compostela, Spain.
    Insulin analog-related lipoatrophy is a rare complication of this type of treatment. We report a case of severe localized lipoatrophy in different locations in a patient with type 1a diabetes mellitus associated with other autoimmune disease. Read More

    A quantitative comparison of psychological and emotional health measures in 360 plastic surgery candidates: is there a difference between aesthetic and reconstructive patients?
    Ann Plast Surg 2010 Sep;65(3):349-53
    Department of Plastic and Reconstructive Surgery, Royal Free Hospital, London, United Kingdom.
    This study examines the utility of the aesthetic and reconstructive categorization for making treatment decisions in patients seeking facial surgery. A total of 360 patients with aesthetic or combined functional aesthetic deficits were included. Validated psychological scales were used as outcome measures. Read More

    The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.
    Mamm Genome 2009 Aug 8;20(8):462-75. Epub 2009 Aug 8.
    Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA 52242, USA.
    Podosome-type adhesions are actin-based membrane protrusions involved in cell-matrix adhesion and extracellular matrix degradation. Despite growing knowledge of many proteins associated with podosome-type adhesions, much remains unknown concerning the function of podosomal proteins at the level of the whole animal. In this study, the spontaneous mouse mutant nee was used to identify a component of podosome-type adhesions that is essential for normal postnatal growth and development. Read More

    Myositis associated with localized lipodystrophy: an unrecognized condition?
    Eur J Med Res 2009 May;14(5):228-30
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
    Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association with localized lipodystrophy. Immunohistochemical stainings revealed a regular pattern of dystrophin, dysferlin, sarcoglycans, and theletonin. Read More

    Lipodystrophy syndromes.
    Dermatol Clin 2008 Oct;26(4):569-78, ix
    Department of Dermatology, La Paz University Hospital, Universidad Autónoma, Paseo Castellana 261, 28046 Madrid, Spain.
    Lipodystrophy syndromes comprise a group of rare, heterogeneous disorders characterized by progressive loss of fat tissue, mainly from subcutaneous compartment and occasionally affecting visceral fat. Lipoatrophy may be partial, localized, or generalized. The latter cases are usually accompanied by metabolic-related disorders, including insulin resistance, diabetes mellitus, hyperlipemia, progressive hepatic disease and anabolic state. Read More

    Lipomembranous fat necrosis of the subcutaneous tissue.
    Dermatol Clin 2008 Oct;26(4):509-17, viii
    Department of Dermatology, Hospital del Mar. IMAS, Passeig Marítim 25-29, 08003, Barcelona, Spain.
    Lipomembranous fat necrosis (LMFN) is a special subtype of fat necrosis characterized by the development of pseudocystic cavities lined with hyaline-crenulated membranes. This regressive degeneration or localized destruction of adipose tissue has been reported as a focal phenomenon or, rarely, as an extensive one in several pathologic conditions of the subcutaneous tissue. LMFN is frequently observed in patients who have chronic sclerotic infiltrated plaques or tender subcutaneous nodules on the lower extremities, often diagnosed as lipodermatosclerosis. Read More

    [Lipoatrophy associated with rapid-acting insulin analogues in young patients with type 1 diabetes mellitus].
    Pediatr Endocrinol Diabetes Metab 2008 ;14(2):117-8
    Department of Diabeology, Newborn Pathology and Birth Defects, Medical University of Warsaw, Poland.
    Lipoatrophy as a cutaneous complication of insulin therapy has been practically forgotten since the introduction of recombinant human insulin. Here we present two cases of marked lipoatrophy associated with rapid-acting insulin analogues (aspart and lispro) administered with continuous subcutaneous insulin infusion or multiple daily injections in a toddler and a young woman with type 1 diabetes mellitus. The exact mechanisms related to the development of localized lipoatrophy in the insulin injection area are unknown. Read More

    Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response.
    Obesity (Silver Spring) 2008 Oct 17;16(10):2379-87. Epub 2008 Jul 17.
    Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
    To understand the molecular mechanisms underlying the development of dyslipidemia and lipodystrophy that occurs after administration of aspartic acid protease inhibitors, we examined transcriptional profiles using cDNA microarrays in 3T3-L1 adipocytes exposed to 10 micromol/l ritonavir for 2-21 days. The expression levels of approximately 12,000 transcripts were assessed using the MgU74Av2 mouse microarray chip. Ritonavir altered gene expression of inflammatory cytokines, stress response genes localized to endoplasmic reticulum, oxidative stress genes, apoptosis-related genes, and expression of genes involved in cell adhesion and extracellular matrix remodeling. Read More

    Localized abdominal idiopathic lipodystrophy.
    Dermatol Online J 2008 Jul 15;14(7):15. Epub 2008 Jul 15.
    Localized loss of subcutaneous tissue can occur after panniculitis, injections of corticosteroids and other drugs, or associated with infectious, autoimmune or neurologic diseases. The "idiopathic lipoatrophies" are a group of poorly characterized diseases, with focal disappearance of subcutaneous fat, and usually the thighs, abdomen or the ankles are affected. Three subtypes have been described based on clinical presentation: lipoatrophia semicircularis, annular lipoatrophy of the ankles and centrifugal lipodystrophy. Read More

    [Pressure-induced lipoatrophia semicircularis].
    Actas Dermosifiliogr 2008 Jun;99(5):396-8
    Servicio de Dermatología. Hospital Clínico Universitario. Salamanca. España.
    Lipoatrophia semicircularis of the thighs is an uncommon form of localized lipodystrophy characterized by horizontal semicircular depressions distributed to form a band. The asymptomatic, often bilateral, and symmetric lesions are localized on the anterolateral aspect of the thighs. The pathogenesis of these lesions is unknown, although most cases are associated with repetitive trauma. Read More

    Lobular panniculitis at the site of glatiramer acetate injections for the treatment of relapsing-remitting multiple sclerosis. A report of two cases.
    J Cutan Pathol 2008 Apr;35(4):407-10
    Department of Pathology, The University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada.
    Lipoatrophy and localized panniculitis have been described as rare complications of daily subcutaneous glatiramer acetate injections for the treatment of relapsing-remitting multiple sclerosis (MS). We describe the biopsies from two MS patients in a single neurologist's practice who developed clinical lesions of lipoatrophy at the sites of subcutaneous glatiramer acetate injections. These biopsies showed a lobular panniculitis with lipoatrophy that more closely resembled lupus panniculitis than previous reports of localized panniculitis at glatiramer acetate injection sites. Read More

    Localized involutional lipoatrophy with epidermal and dermal changes.
    J Am Acad Dermatol 2008 Mar;58(3):490-3
    Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
    Localized involutional lipoatrophy (LIL) was first described in 1986 as a distinctive idiopathic form of localized lipoatrophy characterized by loss of adipose tissue without antecedent inflammation. Clinically, LIL usually presents as a solitary, asymptomatic, well-demarcated, atrophic depression and often involves areas of antecedent intramuscular or intra-articular injections. Histologically, changes in the subcutaneous fat in LIL resemble fetal adipose tissue. Read More

    The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology.
    Proc Natl Acad Sci U S A 2007 Dec 18;104(52):20890-5. Epub 2007 Dec 18.
    Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA.
    Lipodystrophy is a disorder characterized by a loss of adipose tissue often accompanied by severe hypertriglyceridemia, insulin resistance, diabetes, and fatty liver. It can be inherited or acquired. The most severe inherited form is Berardinelli-Seip Congenital Lipodystrophy Type 2, associated with mutations in the BSCL2 gene. Read More

    Phosphatidylcholine and sodium deoxycholate in the treatment of localized fat: a double-blind, randomized study.
    Dermatol Surg 2008 Jan 5;34(1):60-6; discussion 66. Epub 2007 Dec 5.
    Centro Chirurgico Florence, Florence, Italy.
    Background: Recent articles have introduced the novel concept of chemical lipolysis through local injections. Phosphatidylcholine is the active drug in the commercial preparation used for this purpose, but some studies have suggested that sodium deoxycholate, an excipient of the preparation, could be the real active substance.

    Aim: We decided to investigate whether phosphatidylcholine and sodium deoxycholate have any clinical efficacy in chemical lipolysis and their respective roles. Read More

    A standardized, comprehensive magnetic resonance imaging protocol for rapid and precise quantification of HIV-1-associated lipodystrophy.
    HIV Med 2007 Oct;8(7):413-9
    HIV Medical Treatment and Research Unit, JW Goethe University, Frankfurt, Germany.
    Objectives: Although multiple methods have been proposed, there is no current gold standard for assessing HIV-1-associated lipodystrophy.

    Methods: HIV-1-infected participants were randomly enrolled and surveyed about changes in the abdomen, thigh, cheek and neck areas. Magnetic resonance imaging (MRI) sequences of these sites were obtained. Read More

    [Seipin/BSCL2-related motor neuron disease: Seipinopathy is a novel conformational disease associated with endoplasmic reticulum stress].
    Rinsho Shinkeigaku 2007 Jun;47(6):329-35
    Department of Neurology, School of Medicine, Keio University.
    In 2004, heterozygous mutations (N88S, S90L) in the Seipin/BSCL2 gene were identified in two autosomal dominant motor neuron diseases, distal hereditary motor neuropathy type V (OMIM #182960) and Silver syndrome (OMIM #270685). The Seipin/BSCL2 gene was originally identified as a candidate gene for congenital generalized lipodystrophy type 2 (CGL2) (OMIM #269700). Individuals with homozygous null mutations in seipin have severe lipoatrophy, insulin resistance, hypertriglyceridemia, and mental retardation without any abnormality of the motor neurons. Read More

    Inherited lipodystrophies and the metabolic syndrome.
    Clin Endocrinol (Oxf) 2007 Oct 11;67(4):479-84. Epub 2007 Jun 11.
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
    Lipodystrophies represent a heterogeneous group of diseases characterized by an abnormal subcutaneous fat distribution, the extent of which can vary from localized, to partial, to generalized lipoatrophy. Whereas partial and generalized lipodystrophies are each associated with metabolic abnormalities, the localized form is not. These metabolic changes include insulin resistance with type 2 diabetes, acanthosis nigricans, dyslipidaemia predominantly consisting of hypertriglyceridaemia (associated with the onset of pancreatitis) and depressed HDL cholesterol, liver steatosis and hypertension. Read More

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