2,683 results match your criteria Lipodystrophy HIV


Antiretroviral Therapy-associated Adverse Drug Reactions and their Effects on Virologic Failure- A Retrospective Cohort Study in Nigeria.

Curr HIV Res 2019 Feb 14. Epub 2019 Feb 14.

Pharmacy Department, Jos University Teaching Hospital, Jos. Nigeria.

Background: Adverse drug reactions (ADRs) associated with antiretroviral therapy (ART) can rapidly reverse the gains of ART resulting in poor health outcomes. We need an improved understanding of specific ART-related ADRs that influence virologic outcomes.

Objective: To investigate the frequency of clinical ADRs and assess their effect on virologic failure in patients on ART. Read More

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http://dx.doi.org/10.2174/1389450120666190214144609DOI Listing
February 2019

Efficacy and Safety of Tenofovir Disoproxil Fumarate Versus Low-Dose Stavudine Over 96 Weeks: A Multicountry Randomized, Noninferiority Trial.

J Acquir Immune Defic Syndr 2019 Feb;80(2):224-233

Chennai Antiviral Research and Treatment Clinical Research Site, YRGCARE Medical Centre, Voluntary Health Services, Chennai, India.

Background: Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities of tenofovir disoproxil fumarate (TDF).

Setting: HIV-1-infected treatment-naive adults in India, South Africa, and Uganda. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001908DOI Listing
February 2019
1 Read

Lipodystrophies, dyslipidaemias and atherosclerotic cardiovascular disease.

Pathology 2019 Feb 27;51(2):202-212. Epub 2018 Dec 27.

Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Lipodystrophies are rare, heterogeneous, genetic or acquired, disorders characterised by varying degrees of body fat loss and associated metabolic complications, including insulin resistance, dyslipidaemias, hepatic steatosis and predisposition to atherosclerotic cardiovascular disease (ASCVD). The four main types of lipodystrophy, excluding antiretroviral therapy-induced lipodystrophy in HIV-infected patients, are congenital generalised lipodystrophy (CGL), familial partial lipodystrophy (FPLD), acquired generalised lipodystrophy (AGL) and acquired partial lipodystrophy (APL). This paper reviews the literature related to the prevalence of dyslipidaemias and ASCVD in patients with lipodystrophies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183052
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http://dx.doi.org/10.1016/j.pathol.2018.11.004DOI Listing
February 2019
5 Reads

Prediction of Cardiovascular Disease Risk Using Framingham and Data on Adverse Effect of Antiretroviral Drugs Risk Equation in Relation to Lipodystrophy in HIV Patients on Highly Active Antiretroviral Therapy.

J Glob Infect Dis 2018 Oct-Dec;10(4):182-187

Department of Medicine, AIIMS, Jodhpur, Rajasthan, India.

Background: In the era of high active antiretroviral therapy (HAART), with increasing survival of HIV patients, cardiovascular risk has emerged as a leading health issue.

Aims: This study aims to predict the 10-year cardiovascular disease risk in HIV patients using the Framingham risk score and its modification for HIV-infected patients on HAART, that is, the data on adverse effect of antiretroviral drugs (DAD) prediction equation.

Setting And Design: This is a case control study. Read More

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http://dx.doi.org/10.4103/jgid.jgid_89_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276318PMC
December 2018

Diagnostic accuracy of noninvasive markers of steatosis, NASH and liver fibrosis in HIV-monoinfected individuals at-risk of non-alcoholic fatty liver disease (NAFLD): results from the ECHAM study.

J Acquir Immune Defic Syndr 2018 Dec 12. Epub 2018 Dec 12.

INSERM, Sorbonne Université, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Paris, France.

Background: HIV-monoinfected individuals are at high risk of non-alcoholic fatty liver disease (NAFLD). Non-invasive tests of steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis have been poorly assessed in this population. Using liver biopsy (LB) as a reference, we assessed the accuracy of noninvasive methods for their respective diagnosis: MRI proton-density-fat-fraction (MRI-PDFF), Fibroscan®/CAP and biochemical tests. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001936DOI Listing
December 2018
2 Reads
4.556 Impact Factor

Fat Mass Ratio in Brazilian HIV-infected Patients Under Antiretroviral Therapy and Its Relationship With Anthropometric Measurents.

J Clin Densitom 2018 Aug 22. Epub 2018 Aug 22.

Post Graduation Program in Medical Sciences, UFF, Brazil.

Introduction: Human immunodeficiency virus-related lipodystrophy is characterized by a variety of phenotypes and metabolic changes; however, consensus has not yet been reached on its diagnostic criteria. Different cutoff values for fat mass ratio have been proposed for this specific population as an objective diagnostic criterion for lipodystrophy. This study aimed to establish sex-specific reference values for fat mass ratio and to correlate them with anthropometric measurements for the diagnosis of human immunodeficiency virus-related lipodystrophy. Read More

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http://dx.doi.org/10.1016/j.jocd.2018.07.013DOI Listing

The Impact of Weight Gain During HIV Treatment on Risk of Pre-diabetes, Diabetes Mellitus, Cardiovascular Disease, and Mortality.

Front Endocrinol (Lausanne) 2018 27;9:705. Epub 2018 Nov 27.

Department of Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia.

Since the introduction of combined antiretroviral therapy (cART) and more effective treatments for AIDS, there has been a dramatic shift from the weight loss and wasting that characterised HIV/AIDS (and still does in countries where cART is not readily available or is initiated late) to healthy weight, or even overweight and obesity at rates mirroring those seen in the general population. These trends are attributable to several factors, including the "" weight gain with reversal of the catabolic effects of HIV-infection following cART-initiation, strategies for earlier cART-initiation in the course of HIV-infection which have prevented many people living with HIV-infection from developing wasting, in addition to exposure to the modern obesogenic environment. Older cART regimens were associated with increased risk of body fat partitioning disorders (lipodystrophy) and cardiometabolic complications including atherothrombotic cardiovascular disease (CVD) and diabetes mellitus. Read More

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http://dx.doi.org/10.3389/fendo.2018.00705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277792PMC
November 2018

Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes.

Protein Sci 2019 Mar 22;28(3):587-597. Epub 2018 Dec 22.

Center for Advanced Biotechnology and Medicine, and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, 08854.

Stavudine (d4T, 2',3'-didehydro-2',3'-dideoxythymidine) was one of the first chain-terminating nucleoside analogs used to treat HIV infection. We present the first structure of the active, triphosphate form of d4T (d4TTP) bound to a catalytic complex of HIV-1 RT/dsDNA template-primer. We also present a new strategy for disulfide (S-S) chemical cross-linking between N of a modified adenine at the second overhang base to I63C in the fingers subdomain of RT. Read More

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http://dx.doi.org/10.1002/pro.3559DOI Listing
March 2019
1 Read

Changes in Waist Circumference in HIV-Infected Individuals Initiating a Raltegravir or Protease Inhibitor Regimen: Effects of Sex and Race.

Open Forum Infect Dis 2018 Nov 16;5(11):ofy201. Epub 2018 Nov 16.

University of California, Los Angeles, Los Angeles, California.

Background: This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size.

Methods: We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 antiretroviral regimens: raltegravir (RAL) or the protease inhibitors (PIs) atazanavir/ritonavir (ATV/r) or darunavir/ritonavir (DRV/r), each in combination with tenofovir disoproxil fumarate/emtricitabine. Associations of treatment and baseline/demographic characteristics with 96-week WC change were assessed using repeated-measures models. Read More

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http://dx.doi.org/10.1093/ofid/ofy201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239079PMC
November 2018
13 Reads

Efficacy and safety of tenofovir disoproxil fumarate versus low-dose stavudine over 96 weeks: a multi-country randomised, non-inferiority trial.

J Acquir Immune Defic Syndr 2018 Nov 12. Epub 2018 Nov 12.

Chief Medical Officer, YRG Centre for AIDS Research & Education, Voluntary Health Services, Tidal Park Road, Taramani, Chennai 600113, India. Address: YRGCARE Medical Centre, VHS, Chennai, INDIA.

Background: Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities of tenofovir disoproxil fumarate (TDF).

Setting: HIV-1-infected treatment-naive adults in India, South Africa and Uganda METHODS: A phase-4, 96-week, randomized, double-blind, non-inferiority trial compared d4T 20mg BD and TDF, taken in combination with lamivudine (3TC) and efavirenz (EFV). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001908DOI Listing
November 2018
16 Reads

Association of raltegravir use with long-term health outcomes in HIV-infected patients: an observational post-licensure safety study in a large integrated healthcare system.

HIV Clin Trials 2018 10 27;19(5):177-187. Epub 2018 Oct 27.

c Division of Research , Kaiser Permanente Northern California , Oakland , CA , USA.

Background: Raltegravir became the first integrase inhibitor to gain FDA approval; but with limited evidence documenting long-term risks in real world care, especially for major health outcomes of interest.

Objective: Assess raltegravir safety in clinical practice within an integrated health system.

Methods: We conducted a cohort study of HIV-infected adults within Kaiser Permanente California from 2005 to 2013. Read More

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https://www.tandfonline.com/doi/full/10.1080/15284336.2018.1
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http://dx.doi.org/10.1080/15284336.2018.1523826DOI Listing
October 2018
16 Reads

Long-Term Correction of Iatrogenic Lipoatrophy With Volumizing Hyaluronic Acid Filler.

Dermatol Surg 2018 11;44 Suppl 1:S60-S62

Directory of Dermatology, Aesthetx, Campbell, California Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Department of Dermatology, University of California, Los Angeles, California.

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http://dx.doi.org/10.1097/DSS.0000000000001417DOI Listing
November 2018
1 Read

18F-FDG Uptake in Subcutaneous Fat Preceding Clinical Diagnosis of Human Immunodeficiency Virus-Associated Lipodystrophy.

Clin Nucl Med 2018 Dec;43(12):e475-e476

From the Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

A 62-year-old man with human immunodeficiency virus (HIV) on long-standing highly active antiretroviral therapy presented for F-FDG PET/CT evaluation of a pulmonary nodule. The examination showed unusual radiotracer distribution accumulating in the subcutaneous and visceral fat with low cerebral and skeletal muscle uptake. Imaging features were consistent with HIV-associated lipodystrophy, an unsuspected diagnosis that was later confirmed on physical examination. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002298DOI Listing
December 2018
8 Reads

Diabetes and HIV.

Curr Diab Rep 2018 Oct 8;18(11):125. Epub 2018 Oct 8.

National Obesity Center and Endocrine and Metabolic Diseases Unit, Yaoundé Central Hospital, Yaoundé, Cameroon.

Purpose Of Review: This review seeks to address the epidemiology and pathophysiological basis of the interaction between HIV infection and diabetes and the implication for treatment. Its importance stems from the current context of the growing burden of both conditions and the possible mechanisms of interactions that may exist but not yet sufficiently examined.

Recent Findings: HIV infection is associated with increased risk of insulin resistance, and ART is associated with metabolic derangement and the occurrence of type 2 diabetes. Read More

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http://link.springer.com/10.1007/s11892-018-1076-3
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http://dx.doi.org/10.1007/s11892-018-1076-3DOI Listing
October 2018
13 Reads

Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications.

Front Pharmacol 2018 4;9:1004. Epub 2018 Sep 4.

School of Chinese Medicine, China Medical University, Taichung, Taiwan.

Antiretroviral (ART) drugs has previously been associated with lipodystrophic syndrome, metabolic consequences, and neuropsychiatric complications. ART drugs include three main classes of protease inhibitors (PIs), nucleoside analog reverse transcriptase inhibitors (NRTIs), and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our previous work demonstrated that a high risk of hyperlipidemia was observed in HIV-1-infected patients who received ART drugs in Taiwan. Read More

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http://dx.doi.org/10.3389/fphar.2018.01004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131569PMC
September 2018
18 Reads

Lipodystrophy Increases the Risk of CKD Development in HIV-Positive Patients in Switzerland: The LIPOKID Study.

Kidney Int Rep 2018 Sep 8;3(5):1089-1099. Epub 2018 May 8.

Division of Infectious Diseases, HIV Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Introduction: Antiretroviral therapy has improved the life expectancy of patients living with HIV. However, lipodystrophy syndrome (LD) remains prevalent, affecting mostly patients treated with first-generation antiretroviral drugs. This syndrome is characterized by changes in body fat distribution with or without associated metabolic changes. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127405PMC
September 2018
3 Reads

Low prevalence of lipodystrophy in HIV-infected Senegalese children on long-term antiretroviral treatment: the ANRS 12279 MAGGSEN Pediatric Cohort Study.

BMC Infect Dis 2018 Aug 6;18(1):374. Epub 2018 Aug 6.

Centre Hospitalier National d'Enfants Albert Royer, Dakar, Sénégal.

Background: The long-term benefits of antiretroviral treatment (ART) are associated with metabolic complications, especially lipodystrophy, which has been well described among HIV-infected adults and children on ART in developed settings. Specifically, stavudine, and to a lesser extent zidovudine and protease inhibitors (PI), have been consistently implicated in the development of lipodystrophy. In 2006, following advice from the WHO, Senegal began phasing out stavudine from first-line ART. Read More

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http://dx.doi.org/10.1186/s12879-018-3282-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090843PMC
August 2018
5 Reads

The impact of a therapeutic exercise intervention on depression and body self-image in HIV-positive women in sub-Saharan Africa.

HIV AIDS (Auckl) 2018 16;10:133-144. Epub 2018 Jul 16.

Department of Human Movement Science, Faculty of Health Sciences, University of Fort Hare, Alice, South Africa.

Introduction: Attitudes, responses, and reactions of HIV-positive women in three sub-Saharan African regions toward a therapeutic exercise intervention, aimed to determine the presence of depression and low body self-image, were captured. This provided insight into body satisfaction and desire to exercise (Stage 1, n=60), body self-image and depression (Stage 2, n=60), and overall concerns around the often adverse side effects of antiretroviral treatment (ART). A program of therapeutic (specialty) exercise was developed for the experimental design (Stage 2), to quantify the psychological side effects of these variables. Read More

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https://www.dovepress.com/the-impact-of-a-therapeutic-exerci
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http://dx.doi.org/10.2147/HIV.S167005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053174PMC
July 2018
7 Reads

Reply: Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus-Associated Lipodystrophy: A Clinical Trial.

Plast Reconstr Surg 2018 10;142(4):584e

Department of Plastic Surgery, University Hospital Gregorio Marañón, Madrid, Spain.

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http://dx.doi.org/10.1097/PRS.0000000000004742DOI Listing
October 2018
2 Reads

Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus-Associated Lipodystrophy: A Clinical Trial.

Plast Reconstr Surg 2018 10;142(4):583e-584e

Aristotle University of Thessaloniki, Thessaloniki, Greece.

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http://dx.doi.org/10.1097/PRS.0000000000004741DOI Listing
October 2018
1 Read

Diabetes mellitus in HIV-infected patients: fasting glucose, A1c, or oral glucose tolerance test - which method to choose for the diagnosis?

BMC Infect Dis 2018 Jul 6;18(1):309. Epub 2018 Jul 6.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar São João, and Faculty of Medicine, i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.

Background: Antiretroviral therapy dramatically reduced HIV-related morbidity and mortality, prolonging the lifespan of HIV-infected patients. Greater duration of infection and exposure to antiretroviral therapy makes these patients susceptible to traditional cardio-metabolic risk factors and pathologies. The optimal diagnostic protocol for Diabetes Mellitus in these patients is still controversial. Read More

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http://dx.doi.org/10.1186/s12879-018-3221-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035413PMC
July 2018
8 Reads

High Irisin levels in nondiabetic HIV-infected males are associated with insulin resistance, nonalcoholic fatty liver disease, and subclinical atherosclerosis.

Clin Endocrinol (Oxf) 2018 Oct 16;89(4):414-423. Epub 2018 Jul 16.

Department of Clinical Medicine, University Miguel Hernandez, Alicante, Spain.

Objective: HIV infection is associated with an increased risk of cardiovascular disease. Irisin is a miokyne secreted by skeletal muscle, which may influence insulin homeostasis, nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Our objective was to evaluate the relationships between serum irisin, insulin homeostasis, NAFLD and subclinical atherosclerosis in HIV-infected males. Read More

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http://dx.doi.org/10.1111/cen.13800DOI Listing
October 2018
8 Reads

Lipodystrophy diagnosis in people living with HIV/AIDS: prediction and validation of sex-specific anthropometric models.

BMC Public Health 2018 Jun 27;18(1):806. Epub 2018 Jun 27.

Interunit Nursing Doctoral Program, College of Nursing of the University of Sao Paulo, Avenida dos Bandeirantes, Campus Universitario, 3900, Ribeirao Preto, SP, 14040-902, Brazil.

Background: Body composition alterations, or lipodystrophy, can lead to serious health problems in people living with HIV/AIDS (PLWHA). The objectives of this study are to predict and validate sex-specific anthropometric predictive models for the diagnosis of lipodystrophy in PLWHA.

Methods: A cross-sectional design was employed to recruit 106 PLWHA (men = 65 and women = 41) in Brazil during 2013-2014. Read More

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http://dx.doi.org/10.1186/s12889-018-5707-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020387PMC
June 2018
18 Reads

Anthropometric definitions for antiretroviral-associated lipodystrophy derived from a longitudinal South African cohort with serial dual-energy X-ray absorptiometry measurements.

Int J STD AIDS 2018 Oct 26;29(12):1194-1203. Epub 2018 Jun 26.

1 Department of Medicine, Division of Diabetic Medicine and Endocrinology, University of Cape Town, Cape Town, South Africa.

The development of lipodystrophy is associated with the long-term use of antiretroviral therapy (ART). We assessed agreement between patient-reported lipodystrophy and body composition measures using dual-energy X-ray absorptiometry (DXA) and developed objective measures to define lipoatrophy and lipohypertrophy in black South Africans. One hundred and eighty-seven ART-naïve HIV-infected adults were enrolled in a 24-month longitudinal study. Read More

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http://journals.sagepub.com/doi/10.1177/0956462418778649
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http://dx.doi.org/10.1177/0956462418778649DOI Listing
October 2018
12 Reads

Effect of combined training on body composition and metabolic variables in people living with HIV: A randomized clinical trial.

Cytokine 2018 Nov 11;111:505-510. Epub 2018 Jun 11.

Department of Physiological Sciences, State University of Maringá, Maringá, Brazil. Electronic address:

Purpose: The aim of this study was to conduct a randomized clinical trial to assess the effects of 16 weeks of combined training on body composition, lipid profile, adiponectin, C-reactive protein (CRP), and leptin levels in people living with HIV/AIDS (PLWHA).

Methods: Fifty-eight HIV-infected individuals were randomized into a training group (T) or a control group (C). Combined training consisted of aerobic and resistance exercises performed at the same training session, applied at a frequency of three times a week for a total of 16 weeks. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.05.028DOI Listing
November 2018
1 Read

Osteonecrosis of the femoral head in people living with HIV: anatomopathological description and p24 antigen test.

HIV AIDS (Auckl) 2018 25;10:83-90. Epub 2018 May 25.

Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, Sao Paulo, Brazil.

Objective: To examine the presence of HIV in bone tissue of people living with HIV (PLWHIV) with osteonecrosis of femoral head and describe clinical and anatomopathological findings.

Design: This is a case series which included 44 PLWHIV with osteonecrosis of femoral head who underwent total hip arthroplasty.

Methods: Clinical data were obtained through analysis of the patients' medical records. Read More

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http://dx.doi.org/10.2147/HIV.S162305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975606PMC
May 2018
32 Reads

Histological and Molecular Adipose Tissue Changes Are Related to Metabolic Syndrome Rather Than Lipodystrophy in Human Immunodeficiency Virus-Infected Patients: A Cross-Sectional Study.

J Infect Dis 2018 Aug;218(7):1090-1098

Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.

Background: In human immunodeficiency virus (HIV)-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy.

Methods: This is a cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. Read More

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http://dx.doi.org/10.1093/infdis/jiy284DOI Listing
August 2018
6 Reads

Deciphering natural control of HIV-1: A valuable strategy to achieve antiretroviral therapy termination.

Cytokine Growth Factor Rev 2018 04 5;40:90-98. Epub 2018 Apr 5.

Institut National de la Recherche Scientifique (INRS)-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, H7V 1B7, QC, Canada. Electronic address:

Antiretroviral therapy (ART) has dramatically reduced HIV-1-associated morbidity and mortality, and has transformed HIV-1 infection into a manageable chronic condition by suppressing viral replication. However, despite recent patient care improvements, ART still fails to cure HIV-1 infection due to the inability to counteract immune defects and metabolic disturbances that are associated with residual inflammation alongside viral persistence. Life-long drug administration also results in multiple side-effects in patients including lipodystrophy and insulin resistance. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2018.03.010DOI Listing
April 2018
5 Reads

Renal complications of lipodystrophy: A closer look at the natural history of kidney disease.

Clin Endocrinol (Oxf) 2018 Jul 17;89(1):65-75. Epub 2018 May 17.

Division of Endocrinology and Metabolism, Brehm Center for Diabetes Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Objectives: Lipodystrophy syndromes are a group of heterogeneous disorders characterized by adipose tissue loss. Proteinuria is a remarkable finding in previous reports.

Study Design: In this multicentre study, prospective follow-up data were collected from 103 subjects with non-HIV-associated lipodystrophy registered in the Turkish Lipodystrophy Study Group database to study renal complications in treatment naïve patients with lipodystrophy. Read More

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http://dx.doi.org/10.1111/cen.13732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999575PMC
July 2018
12 Reads
3.460 Impact Factor

Lipoatrophy/lipohypertrophy outcomes after antiretroviral therapy switch in children in the UK/Ireland.

PLoS One 2018 4;13(4):e0194132. Epub 2018 Apr 4.

Medical Research Council Clinical Trials Unit at University College, London, United Kingdom.

Background: Following widespread use of stavudine, a thymidine analogue, in antiretroviral therapy (ART) over the past three decades, up to a third of children developed lipoatrophy (LA) and/or lipohypertrophy (LH). Following phasing-out of stavudine, incidence of newly-diagnosed LA and LH declined dramatically. However, the natural history of existing cases should be explored, particularly with prolonged protease inhibitor exposure. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194132PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884482PMC
July 2018
2 Reads

Dermatological conditions associated with HIV medication in a cohort of Greek patients initiating antiretroviral therapy: 1988-2013.

J Virus Erad 2018 Jan 1;4(1):26-29. Epub 2018 Jan 1.

Dermatology Department, AIDS Unit, Andreas Syggros Hospital, Athens, Greece.

 Treatment of HIV infection has evolved from a single antiretroviral agent to combination therapy, which has dramatically improved both the quality of life and life expectancy of affected patients. The aim of this study was to review HIV treatment-associated dermatological conditions observed in adult patients receiving antiretroviral therapy (ART) in a single tertiary care referral centre over time.  We reviewed the files of HIV-positive patients seen at the Dermatology Department, AIDS Clinic of the Andreas Syggros Hospital, Athens, Greece who had initiated ART from 1988 to 2013, for evidence of dermatological conditions commonly associated with HIV-related medication. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851181PMC
January 2018
5 Reads

Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice.

Exp Ther Med 2018 Feb 17;15(2):1314-1320. Epub 2017 Nov 17.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Highly active antiretroviral therapy (HAART) has successfully reduced the mortality rate of patients with human immune deficiency virus (HIV) and HIV protease inhibitors (HIV PIs) are key components of HAART. Complications of HAART, particularly those associated with HIV PIs including lipodystrophy and metabolic disturbance, have emerged as an important public health issue. No specific treatment is available to prevent and/or treat HIV PI-associated lipodystrophy and metabolic syndrome. Read More

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http://dx.doi.org/10.3892/etm.2017.5526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774418PMC
February 2018
2 Reads

Metabolic Effects of Preexposure Prophylaxis With Coformulated Tenofovir Disoproxil Fumarate and Emtricitabine.

Clin Infect Dis 2018 Jul;67(3):411-419

Gladstone Institute of Virology, California.

Background: Antiretroviral drugs have been associated with changes in lipids, fat mass and dat distribution. Tenofovir disoproxil fumarate (TDF) has been shown to have a more favorable metabolic profile than other drugs in its class. However, the metabolic effects of TDF in preexposure prophylaxis (PrEP) are unknown. Read More

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http://dx.doi.org/10.1093/cid/ciy083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051460PMC
July 2018
10 Reads

Incidence and Risk Factors for Prediabetes and Diabetes Mellitus Among HIV-infected Adults on Antiretroviral Therapy: A Systematic Review and Meta-analysis.

Epidemiology 2018 05;29(3):431-441

Objective: To summarize evidence on the rates and drivers of progression from normoglycemia to prediabetes and/or diabetes mellitus (hereafter "diabetes") in antiretroviral treatment (ART)-exposed HIV-infected people.

Methods: We searched EMBASE, PubMed, Web of Science, and Global Index Medicus to identify articles published from 1 January 2000 to 30 April 2017. A random-effects model produced a summary estimate of the incidence across studies and heterogeneity was assessed using Cochrane's Q statistic. Read More

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http://dx.doi.org/10.1097/EDE.0000000000000815DOI Listing
May 2018
7 Reads
3 Citations
6.200 Impact Factor

Substituting Abacavir for Stavudine in Children Who Are Virally Suppressed Without Lipodystrophy: Randomized Clinical Trial in Johannesburg, South Africa.

J Pediatric Infect Dis Soc 2018 Aug;7(3):e70-e77

Gertrude H. Sergievsky Center, Columbia University.

Objectives: Abacavir has replaced stavudine in antiretroviral therapy (ART) regimens because it has largely been phased out as a result of toxicity concerns; this loss has reduced further the already-limited drug options for children. Few data regarding virologic and metabolic outcomes among children who undergo substitution of stavudine exist. We evaluated the effects of preemptive substitution of abacavir for stavudine in children initially without lipodystrophy and virally suppressed on a stavudine-containing regimen. Read More

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http://dx.doi.org/10.1093/jpids/pix110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097575PMC
August 2018
9 Reads

Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism-Role of HIV lipodystrophy.

PLoS One 2018 17;13(1):e0186755. Epub 2018 Jan 17.

Department of Physiology, Medical University of Bialystok, Bialystok, Poland.

Introduction: Interleukin (IL)-18 is involved in regulation of lipid and glucose metabolism. Mice lacking whole-body IL-18 signalling are prone to develop weight gain and insulin resistance, a phenotype which is associated with impaired fat oxidation and ectopic skeletal muscle lipid deposition. IL-18 mRNA is expressed in human skeletal muscle but a role for IL-18 in muscle has not been identified. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186755PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771554PMC
January 2018
14 Reads

Visceral adipose tissue and carotid intima-media thickness in HIV-infected patients undergoing cART: a prospective cohort study.

BMC Infect Dis 2018 01 11;18(1):32. Epub 2018 Jan 11.

Endocrinology Department, Hospital de São João and University of Porto Medical School, Porto, Portugal.

Background: Combined antiretroviral therapy (cART) in HIV-infected patients has been associated with lipodystrophy, metabolic abnormalities, and an increased risk of cardiovascular disease. Ultrasound measures of carotid artery intima-media thickness (cIMT) have been used as a valid measure of subclinical atherosclerosis and as a tool to predict the risk of cardiovascular events. Our aim was to evaluate the progression of cIMT in HIV-infected patients subjected to cART, with and without lipodystrophy, over a one-year period. Read More

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http://dx.doi.org/10.1186/s12879-017-2884-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765644PMC
January 2018
38 Reads

Endocrinological aspects of HIV infection.

J Endocrinol Invest 2018 Aug 8;41(8):881-899. Epub 2018 Jan 8.

Division of Infectious Diseases, UConn Health, Farmington, CT, 06030, USA.

Purpose: Patients with human immunodeficiency virus (HIV) are living longer with effective antiretroviral therapies and are enjoying near normal life span. Therefore, they are encountering endocrine issues faced by the general population along with those specific to HIV infection. The purpose of this article is to review the common endocrine aspects of HIV infection, and the early detection and management strategies for these complications. Read More

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http://dx.doi.org/10.1007/s40618-017-0812-xDOI Listing
August 2018
2 Reads

[Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach].

Acta Med Port 2017 Oct 31;30(10):742-749. Epub 2017 Oct 31.

Laboratório de Fisiologia. Instituto de Imagem Biomédica e Ciências da Vida (IBILI). Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.

Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. Read More

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http://dx.doi.org/10.20344/amp.8726DOI Listing
October 2017
7 Reads

Motives for change of first-line antiretroviral therapy regimens in an unselected cohort of HIV/AIDS patients at a major referral centre in South-west Cameroon.

BMC Res Notes 2017 Nov 28;10(1):623. Epub 2017 Nov 28.

Foumbot District Hospital, Foumbot, Cameroon.

Objective: The rapid scale-up of antiretroviral therapy (ART) coverage in sub-Saharan Africa has encountered the challenge of maintaining international clinical standards of ART utilization and change of ART regimens. In Cameroon, scarce reports have documented the motives for change of ART. This study had as objective to investigate the reasons for switch in ART through a secondary analysis and descriptive synthesis of data from a cross-sectional study at the Limbe Regional Hospital. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-017-2948-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704546PMC
November 2017
13 Reads

Body fat redistribution and changes in lipid and glucose metabolism in people living with HIV/AIDS.

Rev Bras Epidemiol 2017 Jul-Sep;20(3):526-536

Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - Ribeirão Preto (SP), Brasil.

Introduction: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART).

Objective: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART.

Methods: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC). Read More

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http://dx.doi.org/10.1590/1980-5497201700030014DOI Listing
August 2018
10 Reads

Reduced bone mineral density in human immunodeficiency virus-infected individuals: a meta-analysis of its prevalence and risk factors.

Osteoporos Int 2018 03 20;29(3):595-613. Epub 2017 Nov 20.

Department of Medicine (Infectious Disease), University of Malaya, Kuala Lumpur, Malaysia.

A meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary. Read More

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http://dx.doi.org/10.1007/s00198-017-4305-8DOI Listing
March 2018
4 Reads

Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam.

AIDS Res Treat 2017 11;2017:3896539. Epub 2017 Oct 11.

Department of Behavioral Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

Background: HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania.

Methods: Analysis included 466 HIV-infected patients. Read More

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https://www.hindawi.com/journals/art/2017/3896539/
Publisher Site
http://dx.doi.org/10.1155/2017/3896539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660755PMC
October 2017
10 Reads

Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus-Associated Lipodystrophy: A Clinical Trial.

Plast Reconstr Surg 2018 03;141(3):613-623

Madrid, Spain From the Department of Plastic Surgery, University Hospital Gregorio Marañón.

Background: The objective of this study was to evaluate and compare the safety and effectiveness of four different dermal fillers in the treatment of facial lipoatrophy secondary to human immunodeficiency virus.

Methods: The authors conducted a clinical trial including 147 patients suffering from human immunodeficiency virus-induced lipoatrophy treated with Sculptra (poly-L-lactic acid), Radiesse (calcium hydroxylapatite), Aquamid (polyacrylamide), or autologous fat. Objective and subjective changes were evaluated during a 24-month follow-up. Read More

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http://Insights.ovid.com/crossref?an=00006534-201803000-0001
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http://dx.doi.org/10.1097/PRS.0000000000004173DOI Listing
March 2018
19 Reads

Commentary on Polyalkylimide.

Dermatol Surg 2018 04;44(4):568

South Beach Dermatology, Miami Beach, Florida.

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http://dx.doi.org/10.1097/DSS.0000000000001334DOI Listing
April 2018
6 Reads

Iatrogenic Cushing Syndrome in a 47-Year-Old HIV-Positive Woman on Ritonavir and Inhaled Budesonide.

J Int Assoc Provid AIDS Care 2017 Nov/Dec;16(6):531-534. Epub 2017 Nov 6.

1 Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA.

Iatrogenic Cushing syndrome (CS) is a well-known complication of treating patients with systemic steroids. More rarely, it has been described in HIV-positive patients on ritonavir (RTV) while using the inhaled corticosteroid fluticasone, which is metabolized through the cytochrome P450 3A4 (CYP3A4) enzyme system. In the presence of RTV, a known CYP3A4 enzyme inhibitor, the interaction can result in impaired metabolism and systemic accumulation of inhaled fluticasone resulting in iatrogenic CS. Read More

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http://dx.doi.org/10.1177/2325957417736612DOI Listing
September 2018
9 Reads

Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges.

Diabetes Metab Syndr Obes 2017 13;10:375-383. Epub 2017 Sep 13.

Complete HEOR Solutions (CHEORS), North Wales, PA, USA.

Background: Lipodystrophy (LD; non-human immunodeficiency virus [HIV]-associated) syndromes are a rare body of disorders for which true prevalence is unknown. Prevalence estimates of rare diseases are important to increase awareness and financial resources. Current qualitative and quantitative estimates of LD prevalence range from ~0. Read More

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http://dx.doi.org/10.2147/DMSO.S130810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604558PMC
September 2017
18 Reads

A Comparison of Adverse Drug Reaction Profiles in Patients on Antiretroviral and Antitubercular Treatment in Zimbabwe.

Clin Drug Investig 2018 Jan;38(1):9-17

Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P O Box A178, Avondale, Harare, Zimbabwe.

Introduction: Few studies describe the adverse drug event profiles in patients simultaneously receiving antiretroviral and anti-tubercular medicines in resource-limited countries.

Objectives: To describe and compare the adverse drug reaction profiles in patients on highly active antiretroviral therapy only (HAART), HAART and isoniazid preventive therapy (HHART), and HAART and antitubercular treatment (ATTHAART).

Methods: We analysed individual case safety reports (ICSRs) for patients on antiretroviral therapy and antitubercular treatment submitted to the national pharmacovigilance centre during the targeted spontaneous reporting (TSR) programme from 1 September 2012 through 31 August 2016. Read More

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http://dx.doi.org/10.1007/s40261-017-0579-zDOI Listing
January 2018
116 Reads