2,738 results match your criteria Lipodystrophy HIV


HIV and antiretroviral therapy-related fat alterations.

Nat Rev Dis Primers 2020 Jun 18;6(1):48. Epub 2020 Jun 18.

Sorbonne Université, Faculty of Medicine, Inserm UMR_S938, Saint-Antoine Research Centre, FRM EQU201903007868, ICAN, RHU CARMMA, Paris, France.

Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss (lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a frequent condition among people living with HIV (PLWH) receiving combination antiretroviral therapy. The subsequent identification of thymidine analogue nucleoside reverse transcriptase inhibitors as the cause of lipoatrophy led to the development of newer antiretroviral agents; however, studies have demonstrated continued abnormalities in fat and/or lipid storage in PLWH treated with newer drugs (including integrase inhibitor-based regimens), with fat gain due to restoration to health in antiretroviral therapy-naive PLWH, which is compounded by the rising rates of obesity. The mechanisms of fat alterations in PLWH are complex, multifactorial and not fully understood, although they are known to result in part from the direct effects of HIV proteins and antiretroviral agents on adipocyte health, genetic factors, increased microbial translocation, changes in the adaptive immune milieu after infection, increased tissue inflammation and accelerated fibrosis. Read More

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http://dx.doi.org/10.1038/s41572-020-0181-1DOI Listing

The HIV Outpatient Study-25 Years of HIV Patient Care and Epidemiologic Research.

Open Forum Infect Dis 2020 May 11;7(5):ofaa123. Epub 2020 Apr 11.

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: The clinical epidemiology of treated HIV infection in the United States has dramatically changed in the past 25 years. Few sources of longitudinal data exist for people with HIV (PWH) spanning that period. Cohort data enable investigating new exposure and disease associations and monitoring progress along the HIV care continuum. Read More

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http://dx.doi.org/10.1093/ofid/ofaa123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235508PMC

Association of the polymorphisms of the genes APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) with lipodystrophy in people living with HIV on antiretroviral therapy: a systematic review.

Mol Biol Rep 2020 Jun 22;47(6):4779-4787. Epub 2020 Apr 22.

Faculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil.

The aim of this study was to perform a systematic review to identify data reported in the literature concerning the association of APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) polymorphisms with lipodystrophy in people living with HIV (PLWHIV) on antirretroviral therapy. The research was conducted in six databases and the studies were selected in two steps. First, a search was undertaken in the following electronic databases: PubMed, Science Direct, Medline, World Wide Science, Directory of Open Access Journals, Scielo, Lilacs and Medcarib. Read More

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http://dx.doi.org/10.1007/s11033-020-05441-3DOI Listing

LipoDDx: a mobile application for identification of rare lipodystrophy syndromes.

Orphanet J Rare Dis 2020 Apr 2;15(1):81. Epub 2020 Apr 2.

Thyroid and Metabolic Diseases Unit (U.E.T.eM.), Department of Psychiatry, Radiology, Public Health, Nursing and Medicine (Medicine Area), Center for Research in Molecular Medicine and Chronic Diseases (CIMUS)-IDIS, University of Santiago de Compostela, Avda. de Barcelona 3, 15706, Santiago de Compostela, Spain.

Background: Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Read More

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http://dx.doi.org/10.1186/s13023-020-01364-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118879PMC

Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology.

J Mol Biol 2020 Mar 19. Epub 2020 Mar 19.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

Ste24, an integral membrane protein zinc metalloprotease, is found in every kingdom of eukaryotes. It was discovered approximately 20 years ago by yeast genetic screens identifying it as a factor responsible for processing the yeast mating a-factor pheromone. In animals, Ste24 processes prelamin A, a component of the nuclear lamina; mutations in the human ortholog of Ste24 diminish its activity, giving rise to genetic diseases of accelerated aging (progerias). Read More

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http://dx.doi.org/10.1016/j.jmb.2020.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172729PMC

High levels of viral repression, malnutrition and second-line ART use in adolescents living with HIV: a mixed methods study from Myanmar.

BMC Infect Dis 2020 Mar 20;20(1):241. Epub 2020 Mar 20.

Médecins Sans Frontières, Geneva, Switzerland.

Background: Adolescents living with HIV/AIDS (ALHIV) are a particularly vulnerable but often overlooked group in the HIV response despite additional disease management challenges.

Methods: All ALHIV (10-19 years), on ART for ≥6 months, presenting to care at a Médecins Sans Frontières (MSF) clinic in Myanmar from January-April 2016 were eligible for the quantitative study component (clinical history, medical examination, laboratory investigation). A subset of these respondents were invited to participate in qualitative interviews. Read More

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http://dx.doi.org/10.1186/s12879-020-04968-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085147PMC

[Clinical presentation and treatment of primary lipodystrophies].

Rev Med Chil 2019 Nov;147(11):1449-1457

Departamento de Nutrición, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Lipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. Read More

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http://dx.doi.org/10.4067/S0034-98872019001101449DOI Listing
November 2019
0.373 Impact Factor

Lipodystrophic syndrome of HIV and associated factors: a study in a university hospital.

Cien Saude Colet 2020 Mar 7;25(3):989-998. Epub 2018 Jul 7.

Programa de Residência em Nutrição Clínica, Hospital das Clínicas, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego 1235, Cidade Universitária. 50670-901, Recife, PE, Brasil.

The use of antiretroviral drugs has increased the survival of HIV patients, but may have side effects, such as lipodystrophic syndrome. This article aims to identify the frequency of the lipodystrophic syndrome and its associated factors in patients with HIV using antiretroviral therapy. It involved a cross-sectional study with HIV patients, monitored on an outpatient basis. Read More

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http://dx.doi.org/10.1590/1413-81232020253.11772018DOI Listing

Association between changes in body fat distribution, biochemical profile, time of HIV diagnosis, and antiretroviral treatment in adults living with and without virus infection.

Rev Assoc Med Bras (1992) 2020 27;66(1):67-73. Epub 2020 Feb 27.

. Professor e Doutor no Departamento de Ciências Farmacêuticas da Unifesp - Campus Diadema, Diadema, SP, Brasil, Departamento de Patologia e Análises Clínicas, Programa de Pós-graduação em Ciências da Saúde da FMABC, Santo André, SP, Brasil.

Objectives: Individuals living with HIV seem to be more prone to changes in the redistribution of body fat, characterized as lipodystrophy, which may occur in conjunction with metabolic diseases. In the present study, such impacts were assessed in adults with and without HIV and associated with the time of virus diagnosis and treatment with antiretroviral.

Methods: A cross-sectional study with 123 adults, in which 87 had HIV and 36 without HIV, of both sexes, in outpatient follow-up at the Specialized Care Service (SAE) in Macaé-RJ. Read More

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http://dx.doi.org/10.1590/1806-9282.66.1.67DOI Listing

Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.

Genet Mol Biol 2020 14;43(1):e20190142. Epub 2020 Feb 14.

Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Laboratório de Biologia Molecular, Porto Alegre, RS, Brazil.

HIV-infected individuals on chronic use of highly active antiretroviral therapy (HAART) are more likely to develop adipose tissue and metabolic disorders, such as lipodystrophy (LD) and metabolic syndrome (MetS). The development of these phenotypes is known to be multifactorial. Thus, variants in genes implicated in adipogenesis and lipid metabolism may increase susceptibility to LD and MetS. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2019-0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198015PMC
February 2020

Imaging spectrum of abnormal subcutaneous and visceral fat distribution.

Insights Imaging 2020 Feb 13;11(1):24. Epub 2020 Feb 13.

Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga Itabashi-ku, Tokyo, 173-8606, Japan.

Adipose tissue plays multiple and complex roles not only in mechanical cushioning and energy storage but also as an important secretory organ that regulates energy balance and homeostasis multilaterally. Fat tissue is categorized into subcutaneous fat tissue (SCAT) or visceral fat tissue (VSA) depending on its distribution, with the two having different metabolic functions. Near-total lack of fat in congenital/acquired generalized lipodystrophy, cachexia, or any other severe malnutrition condition induces severe multi-organ dysfunction due to lack of production of leptin and other adipokines. Read More

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http://dx.doi.org/10.1186/s13244-019-0833-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018866PMC
February 2020

Physical activity and exercise to improve cardiovascular health for adults living with HIV.

Prog Cardiovasc Dis 2020 Mar - Apr;63(2):178-183. Epub 2020 Jan 31.

College of Nursing, University of Colorado, Aurora, CO, USA.

Pharmacologic advancements in the treatment of human immunodeficiency virus (HIV) has extended the life expectancy of people living with HIV (PLWH). An unfortunate side effect of HIV treatment, however, is an increased prevalence of dyslipidemia, glycemic dysregulation and abnormal distribution of body fat (lipodystrophy). Consequently, the risk of developing cardiovascular disease (CVD) is significantly increased in PLWH and ultimately a major cause of mortality. Read More

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http://dx.doi.org/10.1016/j.pcad.2020.01.005DOI Listing

Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.

J Manag Care Spec Pharm 2020 Feb;26(2):104-116

ViiV Healthcare, Research Triangle, North Carolina.

Background: As life expectancy of patients infected with human immunodeficiency virus (HIV) approaches that of the general population, the composition of HIV management costs is likely to change.

Objectives: To (a) review treatment and disease management costs in HIV, including costs of adverse events (AEs) related to antiretroviral therapy (ART) and long-term toxicities, and (b) explore the evolving cost drivers.

Methods: A targeted literature review between January 2012 and November 2017 was conducted using PubMed and major conferences. Read More

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http://dx.doi.org/10.18553/jmcp.2020.26.2.104DOI Listing
February 2020

European lipodystrophy registry: background and structure.

Orphanet J Rare Dis 2020 01 15;15(1):17. Epub 2020 Jan 15.

Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, Centre for Rare Endocrine Disorders, Ulm University Medical Centre, Eythstraße 24, 89075, Ulm, Germany.

Background: Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy subform, research in this area is difficult and international co-operation mandatory. Therefore, in 2016, the European Consortium of Lipodystrophies (ECLip) decided to create a registry for patients with lipodystrophy. Read More

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http://dx.doi.org/10.1186/s13023-020-1295-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964101PMC
January 2020

Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals.

PLoS One 2019 17;14(12):e0226573. Epub 2019 Dec 17.

Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Although antiretroviral therapy (ART) has resulted in a marked decrease in AIDS-related morbidity and mortality, the therapeutic benefit is often limited by side effects such as metabolic derangement such as lipodystrophy and hyperlipidemia and cardiovascular diseases. These side effects are pervasive in people living with HIV (PLWH). However, the underlying mechanisms are not completely understood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226573PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917281PMC

Psychosocial Correlates of Body Image and Lipodystrophy in Women Aging With HIV.

J Assoc Nurses AIDS Care 2020 Mar-Apr;31(2):157-166

Greer A. Raggio, PhD, MPH, is a Psychologist, National Center for Weight and Wellness, Washington, DC, USA. Sara E. Looby, PhD, ANP-BC, FAAN, is an Assistant Professor of Medicine, Harvard Medical School, and Assistant Professor in Nutrition, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Gregory K. Robbins, MD, MPH, is an Associate Professor of Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Elyse R. Park, PhD, MPH, is an Associate Professor of Psychiatry, Harvard Medical School, Director of Behavioral Services, Massachusetts General Hospital, Tobacco Treatment and Research Center, and the Director of Behavioral Research, Massachusetts General Hospital, Benson-Henry Institute for Mind Body Medicine, Boston, Massachusetts, USA. Elsa W. Sweek, MS, is a Clinical Research Coordinator, Behavioral Medicine Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. Steven A. Safren, PhD, is a Professor of Psychology, Department of Psychology, University of Miami, Coral Gables, Florida, USA. Christina Psaros, PhD, is an Assistant Professor in Psychology, Harvard Medical School, and Associate Director, Behavioral Medicine Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

Body image disturbance is increasingly relevant as women living with HIV (WLWH) live longer. We explored body image disturbance and changes in fat distribution (lipodystrophy) in 63 WLWH (mean age = 51 years) and evaluated associations among lipodystrophy, body image, and psychosocial variables. Eighty-one percent of participants reported one or more body parts (of six assessed) demonstrating lipodystrophy, and more than one third reported three or more affected body parts. Read More

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http://dx.doi.org/10.1097/JNC.0000000000000139DOI Listing
December 2019

Breast abnormalities in adolescents receiving antiretroviral therapy.

South Afr J HIV Med 2019 6;20(1):1017. Epub 2019 Nov 6.

Right to Care, Johannesburg, South Africa.

Background: Antiretrovirals, particularly efavirenz (EFV), have been shown to cause breast abnormalities in adults. Little is known about the prevalence of these adverse effects among adolescents receiving antiretroviral therapy (ART).

Objectives: The aim of this article was to examine the extent of breast abnormalities in adolescents receiving ART and determine any clinical associations. Read More

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http://dx.doi.org/10.4102/sajhivmed.v20i1.1017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852609PMC
November 2019

Left Ventricular Function, Epicardial Adipose Tissue, and Carotid Intima-Media Thickness in Children and Adolescents With Vertical HIV Infection.

J Acquir Immune Defic Syndr 2019 12;82(5):462-467

Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.

Background: Life expectancy of HIV patients has increased considerably as a result of antiretroviral therapy (ART), and cardiovascular (CV) disease has emerged as an important late concern. People with HIV infection could have an impaired systolic function; however data on diastolic function and markers of CV risk, such as epicardial adipose tissue (EAT) and intima-media thickness (IMT), are lacking. Aim of this study is to evaluate left ventricular function, EAT, and IMT in children and adolescents with vertically acquired HIV infection. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002158DOI Listing
December 2019

Self-reported lipodystrophy, nutritional, lipemic profile and its impact on the body image of HIV-1-infected persons, with and without antiretroviral therapy.

AIDS Care 2019 Nov 11:1-6. Epub 2019 Nov 11.

Department of Pathology and Clinical Analysis, Campus Diadema, Universidade Federal de São Paulo, FMABC, Santo André, Brasil.

A cross-sectional study was conducted with 227 adults, 162 using antiretroviral therapy (ART), both sexes, in Secondary Immunodeficiency Outpatient Clinic of the Department of Dermatology of the Hospital das Clínicas of the Faculty of Medicine of University of São Paulo. The patients were grouped into 92 under ART and self-reported lipodystrophy (G1); 70 under ART and without self-reported lipodystrophy (G2); 65 without ART (G3). We evaluated: (1) self-reported lipodystrophy, self-perception and feeling about body image; (2) Anthropometric and lipemic profile. Read More

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http://dx.doi.org/10.1080/09540121.2019.1687832DOI Listing
November 2019

Biological Features Implies Potential Use of Autologous Adipose-Derived Stem/Progenitor Cells in Wound Repair and Regenerations for the Patients with Lipodystrophy.

Int J Mol Sci 2019 Nov 5;20(21). Epub 2019 Nov 5.

Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

A paradigm shift in plastic and reconstructive surgery is brought about the usage of cell-based therapies for wound healing and regeneration. Considering the imitations in the reconstructive surgeries in restoring tissue loss and deficiency, stem cell-based therapy, in particular, has been expected to pave the way for a new solution to the regenerative approaches. Limitations in the reconstructive surgeries in restoring tissue loss and deficiency have paved the way for new regenerative approaches. Read More

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http://dx.doi.org/10.3390/ijms20215505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862495PMC
November 2019
1 Read

Liver enzyme elevation in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital: a comparative cross-sectional study, Northeast Ethiopia.

BMC Res Notes 2019 Oct 30;12(1):714. Epub 2019 Oct 30.

Department of Biochemistry, College of Medicine and Health Sciences, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia.

Objective: HAART had significantly improved the quality of life of HIV patients. However, it results different adverse effects such as: hepatotoxicity, nephrotoxicity, lipodystrophy, anemia, diarrhea, psychiatric disorder and others. Therefore, this comparative cross sectional study was designed to investigate liver enzyme elevation in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital. Read More

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http://dx.doi.org/10.1186/s13104-019-4748-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822479PMC
October 2019
1 Read

Anthropometric cutoff points to identify lipodystrophy characteristics in people living with HIV/AIDS: an observational study.

Nutr Hosp 2019 Dec;36(6):1315-1323

Department of Clinical Medicine. Facultade de Medicina. Universidade de Sao Paulo.

Introduction: Introduction: currently, there is no consensus regarding accurate and low-cost methods for diagnosing lipodystrophy in people living with HIV/AIDS (PLWHA). The aim of this study was to propose anthropometric cutoff points for the diagnosis of lipodystrophy among PLWHA. Methods: we included 106 PLWHA (men = 65, women = 41) who are under antiretroviral therapy and have been clinically classified into either a "lipodystrophy" or "non-lipodystrophy" group. Read More

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http://dx.doi.org/10.20960/nh.02715DOI Listing
December 2019
1 Read

Association between lipodystrophy and length of exposure to ARTs in adult HIV-1 infected patients in Montreal.

BMC Infect Dis 2019 Sep 18;19(1):820. Epub 2019 Sep 18.

CHUM-CRCHUM, Tour Saint-Antoine - 3e étage, local SO3-288, 850, rue Saint-Denis, Montréal, Québec, H2X 0A9, Canada.

Background: The aim of this study was to establish the prevalence of lipodystrophy and its association to cumulative exposure to antiretroviral drugs.

Method: We conducted a cross sectional study in all HIV- infected patients attending the HIV clinic in the Centre hospitalier universitaire de Montréal (CHUM) with DEXA scan. Lipodystrophy was defined as a trunk/limb fat ratio ≥ 1. Read More

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http://dx.doi.org/10.1186/s12879-019-4446-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751890PMC
September 2019
1 Read

Practices in the Usage and Reconstitution of Poly-L-Lactic Acid

J Drugs Dermatol 2019 Sep;18(9):880-886

BACKGROUND: Poly-L-lactic acid (PLLA) is increasingly used for a range of indications, from HIV lipodystrophy to gluteal augmentation; however, there is no clear consensus on appropriate product preparation and use. OBJECTIVE: To establish current practices for PLLA reconstitution and usage in the USA. METHODS AND MATERIALS: A 19-question survey pertaining to the reconstitution and use of PLLA was distributed to members of the American Board of Cosmetic Surgery and American Board of Facial Cosmetic Surgery and at several cosmetic conferences. Read More

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September 2019
1 Read
1.320 Impact Factor

Effect of the duration of protease inhibitor therapy in HIV-infected individuals on the severity of obstructive sleep apnea.

J Res Med Sci 2019 24;24:65. Epub 2019 Jul 24.

Department of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ, USA.

Background: Protease inhibitors (PIs) are a vital part of the antiretroviral therapy. Long-term use of PIs may cause lipodystrophy, a clinical syndrome characterized by peripheral lipoatrophy and central fat accumulation, which may increase the risk of developing obstructive sleep apnea (OSA) in HIV-infected patients. We hypothesize that a longer duration of PIs' use might be associated with increasing severity of OSA in HIV-infected patients. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_892_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669999PMC
July 2019
2 Reads

White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?

Brain Res 2019 12 20;1724:146397. Epub 2019 Aug 20.

Department of Neurology, The Children's Hospital of Philadelphia, United States. Electronic address:

While the severe cognitive effects of HIV-associated dementia have been reduced by combined antiretroviral therapy (cART), nearly half of HIV-positive (HIV+) patients still suffer from some form of HIV-Associated Neurocognitive Disorders (HAND). While frank neuronal loss has been dramatically reduced in HAND patients, white matter loss, including dramatic thinning of the corpus callosum, and loss of volume and structural integrity of myelin persists despite viral control by cART. It remains unclear whether changes in white matter underlie the clinical manifestation seen in patients or whether they are the result of persistent viral reservoirs, remnant damage from the acute infection, the antiretroviral compounds used to treat HIV, secondary effects due to peripheral toxicities or other associated comorbid conditions. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.146397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779527PMC
December 2019
2 Reads

Subcutaneous Adipocyte Adenosine Triphosphate Levels in HIV Infected Patients.

AIDS Res Hum Retroviruses 2020 01 17;36(1):75-82. Epub 2019 Sep 17.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.

Lipoatrophy, or fat wasting, remains a syndrome plaguing HIV patients receiving antiretroviral (ARV) therapy. Both HIV infection and certain ARV are associated with lowered adipose tissue mitochondrial deoxyribonucleic acid (mtDNA) and mitochondrial ribonucleic acid (mtRNA) levels, but effects on adenosine triphosphate (ATP) production are unclear. We hypothesized that such alterations would accompany lowering of ATP levels in fat of HIV patients and would be worse in those displaying lipoatrophy. Read More

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http://dx.doi.org/10.1089/AID.2019.0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944137PMC
January 2020
1 Read

Role of medicinal plants in HIV/AIDS therapy.

Clin Exp Pharmacol Physiol 2019 12 22;46(12):1063-1073. Epub 2019 Aug 22.

University College of Agriculture, University of Sargodha, Sargodha, Pakistan.

Human immunodeficiency virus (HIV) causes the potentially life-threatening and chronic disease called acquired immune deficiency syndrome (AIDS). The main target of this viral disease is to suppress the immune system and make the body unresponsive to external stimuli. According to global health observatory data since epidemic, more than 78 million people were affected by HIV and 39 million people died globally. Read More

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http://dx.doi.org/10.1111/1440-1681.13151DOI Listing
December 2019
4 Reads

Total thyroidectomy in HIV positive patient with buffalo hump and taurine neck.

Int J Surg Case Rep 2019 19;61:64-66. Epub 2019 Jul 19.

Division of Thoracic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via Largo del Pozzo n. 71- 41124 Modena, Italy. Electronic address:

Background: The authors present a case of multinodular goiter in an HIV-positive patient affected by lipodystrophy with particular accumulation of adipose tissue in the region of the neck and trunk.

Case Presentation: The patient, a 53-year-old man, presented with multinodular struma with partial retrosternal engagement, as well as multiple thyroid nodules increasing in size; some of the nodules had suspicious characteristics on ultrasound. Needle aspiration biopsy was difficult to use to determine the presence of lipodystrophy; however, even in the absence of cytology, surgical treatment was necessary due to the presence of dyspnea during exercise, the dimension of the goiter with retrosternal engagement, and the ovalization of the tracheal lumen. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660579PMC
July 2019
3 Reads

Non-Submental Applications of Injectable Deoxycholic Acid: A Systematic Review

J Drugs Dermatol 2019 Jul;18(7):675-680

Introduction: Injectable deoxycholic acid (DCA; Kybella; Allergan, Irvine, CA) is currently approved only for treatment of persistent submental fat (SMF). Many cosmetic surgeons use DCA off-label to treat fat tissue in other areas of the body. There is no review summarizing the off-label uses of injectable DCA. Read More

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July 2019
5 Reads

CT Fat Density Accurately Reflects Histologic Fat Quality in Adults With HIV On and Off Antiretroviral Therapy.

J Clin Endocrinol Metab 2019 10;104(10):4857-4864

University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.

Context: Microscopic measurement of adipocyte size is the gold standard for determining adipose tissue (AT) quality. AT density on CT may also reflect adipocyte quality (lower density = poorer quality).

Objective: We used abdominal subcutaneous AT (SAT) specimens and CT scans to validate CT SAT density as a marker of SAT quality in adults living with HIV. Read More

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http://dx.doi.org/10.1210/jc.2018-02785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733493PMC
October 2019
1 Read

Comorbidities and Survival in Patients With Lipodystrophy: An International Chart Review Study.

J Clin Endocrinol Metab 2019 11;104(11):5120-5135

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Context: Limited natural history data are available in patients with non-HIV-related lipodystrophy syndromes who never received disease-specific therapies, making interpretation of benefits of therapies in lipodystrophy syndromes challenging.

Objective: We assessed the natural history of non-HIV-related generalized lipodystrophy (GL) and partial lipodystrophy (PL) in patients who have never received leptin or other lipodystrophy-specific therapies.

Design/setting/patients: We conducted an international chart review of 230 patients with confirmed GL or PL at five treatment centers who never received leptin or other lipodystrophy-specific therapies. Read More

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http://dx.doi.org/10.1210/jc.2018-02730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760298PMC
November 2019
7 Reads

Metabolic complications affecting adipose tissue, lipid and glucose metabolism associated with HIV antiretroviral treatment.

Expert Opin Drug Saf 2019 Sep 19;18(9):829-840. Epub 2019 Jul 19.

a Faculty of Medicine, Sorbonne Université, Inserm UMR_S938, ICAN , Paris , France.

: Efficient antiretroviral-treatment (ART) generally allows control of HIV infection. However, persons-living-with-HIV (PLWH), when aging, present a high prevalence of metabolic diseases. : Altered adiposity, dyslipidemias, insulin resistance, diabetes, and their consequences are prevalent in PLWH and could be partly related to ART. Read More

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http://dx.doi.org/10.1080/14740338.2019.1644317DOI Listing
September 2019
6 Reads

Human Immunodeficiency Virus Infection and the Endocrine System.

Endocrinol Metab (Seoul) 2019 06;34(2):95-105

Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel.

In the current era of effective antiretroviral therapies (ARTs), human immunodeficiency virus (HIV) infection became a chronic disorder that requires long term follow-up. Among other medical issues, these patients may develop endocrine problems, specific to HIV infection and its treatment. The purpose of this review is to give an overview of common endocrine complications associated with HIV infection, and to propose diagnostic and therapeutic strategies. Read More

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http://dx.doi.org/10.3803/EnM.2019.34.2.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599897PMC
June 2019
4 Reads

Lower serum adiponectin level is associated with lipodystrophy among HIV-infected men in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) study.

HIV Med 2019 09 31;20(8):534-541. Epub 2019 May 31.

Denver Infectious Disease Consultants, Denver, CO, USA.

Objectives: Adiponectin levels are inversely related to cardiovascular risk and are low in diabetics and obese persons. We examined the association between adiponectin concentration and HIV-associated lipodystrophy, which remains unclear.

Methods: The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) was a prospective cohort study of HIV-infected adults conducted in four US cities. Read More

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http://dx.doi.org/10.1111/hiv.12754DOI Listing
September 2019
6 Reads

Psychopathological and psychiatric evaluation of patients affected by lipodystrophy.

Eat Weight Disord 2019 May 29. Epub 2019 May 29.

Endocrinology Unit, Department of Clinical and Experimental Medicine, Obesity and Lipodystrophy Research Center, University Hospital of Pisa, Pisa, Italy.

Purpose: Lipodystrophy is a collection of rare disorders defined by complete or partial loss of adipose tissue, due to abnormal adipocyte production, function, or distribution; it shares the main metabolic complications with obesity. Aims of the present study were to investigate the psychopathological characteristics of non-HIV lipodystrophic patients in comparison with a group of obese patients, a group of patients affected by oncologic chronic illness, and a control group of healthy subjects.

Methods: All participants were female: 16 non-HIV lipodystrophic women (mean age 42 ± 12 years), 20 women with breast cancer (adenocarcinoma with a positive sentinel lymph node in outpatients awaiting chemotherapy, mean age 44 ± 5 years), 20 obese women (mean age 40 ± 3 years), and 20 healthy women (mean age 40 ± 2 years). Read More

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http://dx.doi.org/10.1007/s40519-019-00716-6DOI Listing
May 2019
22 Reads

Fatty liver disease in persons with HIV infection.

Top Antivir Med 2019 May;27(2):75-82

University of Cincinnati College of Medicine, Cincinnati, OH, USA.

The leading cause of non-HIV-related mortality is liver disease. Fatty liver disease can be characterized as alcoholic or nonalcoholic in nature. Alcohol use is prevalent among individuals with HIV infection and can lead to medication nonadherence, lower CD4+ cell count, inadequate viral suppression, and disease progression. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550355PMC
May 2019
12 Reads

Recent developments in lipodystrophy.

Curr Opin Lipidol 2019 08;30(4):284-290

Metabolic Research Laboratories, Wellcome Trust - MRC Institute of Metabolic Science, University of Cambridge.

Purpose Of Review: Lipodystrophy syndromes have an estimated prevalence of 1.3-4.7 cases per million and as with other rare diseases conducting research can be challenging. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000613DOI Listing
August 2019
9 Reads

miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir.

Front Pharmacol 2019 30;10:461. Epub 2019 Apr 30.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Metabolic complications represent a common and serious problem associated with HIV infection and combined Antiretroviral Therapy (cART). Alterations in body fat distribution are associated with significantly increased risks of (i) metabolic derangements, (ii) cardiovascular pathologies, and (iii) insulin resistance. A case control study showed that in subcutaneous adipose tissue from HIV-infected patients on cART presenting lipodystrophy (LS), the levels of miRNA-218 were upregulated and those of lipin-1, a putative target gene of miRNA-218, were downregulated compared with HIV-negative subjects. Read More

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http://dx.doi.org/10.3389/fphar.2019.00461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524698PMC
April 2019
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Natural Course of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Patients With Human Immunodeficiency Virus With and Without Combination Antiretroviral Therapy-associated Lipodystrophy: A 16-Year Follow-up Study.

Clin Infect Dis 2020 Apr;70(8):1708-1716

Minerva Foundation Institute for Medical Research.

Background: Abnormal glucose metabolism and nonalcoholic fatty liver disease (NAFLD) are common in patients with human immunodeficiency virus (HIV+ patients), but longitudinal data are lacking. We determined the natural course of NAFLD (liver fat [LFAT]) and type 2 diabetes mellitus (T2DM) in HIV+ patients with and without lipodystrophy (LD+ and LD-, respectively) during a 16-year longitudinal study.

Methods: LFAT (by proton magnetic resonance spectroscopy) and clinical characteristics were measured in 41 HIV+ patients at baseline and after 16 years. Read More

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http://dx.doi.org/10.1093/cid/ciz435DOI Listing
April 2020
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Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement.

Metabolism 2019 07 6;96:66-82. Epub 2019 May 6.

Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA.

Lipodystrophy is a group of clinically heterogeneous, inherited or acquired, disorders characterized by complete or partial absence of subcutaneous adipose tissue that may occur simultaneously with the pathological, ectopic, accumulation of fat in other regions of the body, including the liver. Fatty liver adds significantly to hepatic and extra-hepatic morbidity in patients with lipodystrophy. Lipodystrophy is strongly associated with severe insulin resistance and related comorbidities, such as hyperglycemia, hyperlipidemia and nonalcoholic fatty liver disease (NAFLD), but other hepatic diseases may co-exist in some types of lipodystrophy, including autoimmune hepatitis in acquired lipodystrophies, or viral hepatitis in human immunodeficiency virus (HIV)-associated lipodystrophy. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.05.001DOI Listing
July 2019
10 Reads

Nature and prevalence of adverse drug reaction of antiretroviral medications in Halibet National Referral Hospital: a retrospective study.

BMC Pharmacol Toxicol 2019 05 6;20(1):24. Epub 2019 May 6.

Asmara College of Health Sciences, P.O box - 1833, Asmara, Eritrea.

Background: Monitoring the safety of antiretroviral therapy (ART) remains a challenge in resource-constrained countries such as Eritrea due to their serious adverse drug reactions (ADRs). This study was aimed at assessing the prevalence, nature, seriousness and possible risk factors of ART associated ADRs in Halibet National Referral Hospital in Eritrea.

Method: A three month retrospective, longitudinal, descriptive study of patients treated with ART between September 2005 and December 2016 was conducted in Halibet National Referral Hospital. Read More

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http://dx.doi.org/10.1186/s40360-019-0307-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503428PMC
May 2019
4 Reads

MRI Assessment of Treatment Response in HIV-associated NAFLD: A Randomized Trial of a Stearoyl-Coenzyme-A-Desaturase-1 Inhibitor (ARRIVE Trial).

Hepatology 2019 11 18;70(5):1531-1545. Epub 2019 Jun 18.

NAFLD Research Center, University of California San Diego Health, La Jolla, CA.

Aramchol, an oral stearoyl-coenzyme-A-desaturase-1 inhibitor, has been shown to reduce hepatic fat content in patients with primary nonalcoholic fatty liver disease (NAFLD); however, its effect in patients with human immunodeficiency virus (HIV)-associated NAFLD is unknown. The aramchol for HIV-associated NAFLD and lipodystrophy (ARRIVE) trial was a double-blind, randomized, investigator-initiated, placebo-controlled trial to test the efficacy of 12 weeks of treatment with aramchol versus placebo in HIV-associated NAFLD. Fifty patients with HIV-associated NAFLD, defined by magnetic resonance imaging (MRI)-proton density fat fraction (PDFF) ≥5%, were randomized to receive either aramchol 600 mg daily (n = 25) or placebo (n = 25) for 12 weeks. Read More

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http://dx.doi.org/10.1002/hep.30674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164416PMC
November 2019
4 Reads

The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa.

Int J Pediatr 2019 3;2019:7013758. Epub 2019 Mar 3.

Division of Cardiology and Infectious Diseases, Department of Pediatrics, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.

Background: Despite the high prevalence of the HIV/AIDS, few studies focused on the prevalence of lipodystrophy in pediatric HIV patients on antiretroviral therapy (ARV) in sub-Saharan African countries. The aim of this study was to assess the prevalence and to identify the risk factors of metabolic disorders related to ARV therapy in this population.

Methods: A cross-sectional study was completed in Kinshasa, the Democratic Republic of Congo. Read More

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https://www.hindawi.com/journals/ijpedi/2019/7013758/
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http://dx.doi.org/10.1155/2019/7013758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420969PMC
March 2019
29 Reads

Ten-Year and Beyond Follow-up After Treatment With Highly Purified Liquid-Injectable Silicone for HIV-Associated Facial Lipoatrophy: A Report of 164 Patients.

Dermatol Surg 2019 07;45(7):941-948

Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Background: Highly purified liquid-injectable silicone (LIS) has been established as a permanent agent for off-label correction of HIV-associated facial lipoatrophy (HIV-FLA). However, controversy exists about long-term safety.

Objective: To establish the safety and efficacy at 10 years or greater of LIS for HIV-FLA. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001889DOI Listing
July 2019
2 Reads