2,203 results match your criteria Lipids in Health and Disease [Journal]


The atherogenic index (ATH index) as a potential predictive marker of idiopathic sudden sensorineural hearing loss: a case control study.

Lipids Health Dis 2019 Mar 15;18(1):64. Epub 2019 Mar 15.

Faculty of Health Sciences, NTNU, Norwegian University of Science and Technology, NTNU, NO-7491, Trondheim, Norway.

Background: The importance of blood lipids in the pathogenesis of sudden sensorineural hearing loss (SSNHL) is widely discussed in the literature. However, the published results that hyperlipidaemia causes hearing problems are contradictory. The objective of this study was to establish whether increased lipid levels affect the risk of idiopathic SSNHL. Read More

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http://dx.doi.org/10.1186/s12944-019-1016-5DOI Listing

LncRNA MALAT1 modulates ox-LDL induced EndMT through the Wnt/β-catenin signaling pathway.

Lipids Health Dis 2019 Mar 14;18(1):62. Epub 2019 Mar 14.

Hebei Medical University, No. 361, Zhongshan East Road, Changan District, Shijiazhuang, 050017, China.

Background: Endothelial-to-mesenchymal transition (EndMT) plays significant roles in atherosclerosis, but the regulatory mechanisms involving lncRNAs remain to be elucidated. Here we sort to identify the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in ox-LDL-induced EndMT.

Methods: The atherosclerosis model was established by feeding ApoE mice with high-fat diet, and the levels of lncRNA MALAT1 in mouse arterial tissue were detected by RT-qPCR. Read More

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http://dx.doi.org/10.1186/s12944-019-1006-7DOI Listing

Effects of selenium-enriched Bacillus sp. compounds on growth performance, antioxidant status, and lipid parameters breast meat quality of Chinese Huainan partridge chicks in winter cold stress.

Lipids Health Dis 2019 Mar 14;18(1):63. Epub 2019 Mar 14.

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Yuanminyuan West Road, Haidian District, Beijing, 100094, China.

Background: Both selenium (Se) and probiotic Bacillus regulate the metabolism to help defense clod stress and improve the meat quality in breeding chicks. The purpose of this study was to evaluate the effect of supplemental Se and Bacillus in the form of Se-enriched Bacillus (SECB) on the growth performance, lipid parameters, breast Se and antibiotic levels, and breast meat quality of chicken in winter cold stress.

Methods: Five hundred 1-d-old chickens were divided into five groups randomly: Control, inorganic Se, compound Bacillus, SECB, and antibiotic. Read More

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http://dx.doi.org/10.1186/s12944-019-1015-6DOI Listing

TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population.

Lipids Health Dis 2019 Mar 9;18(1):61. Epub 2019 Mar 9.

Medical College of Qingdao University, Qingdao, 266071, China.

Background: Dysregulation of the lipid homeostasis is an independent risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies had demonstrated that TRIB1 gene polymorphisms affect the plasma lipids metabolism, but no related data was available for TRIB1 gene polymorphisms in the lipids metabolism in Chinses Han population. The present study was conducted to investigate the association between TRIB1 gene polymorphisms (rs17321515 and rs2954029) and the risk of NAFLD in Chinese Han population and their effects on serum lipid profiles. Read More

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http://dx.doi.org/10.1186/s12944-019-1001-zDOI Listing

Apolipoprotein E gene polymorphism and renal function are associated with apolipoprotein E concentration in patients with chronic kidney disease.

Lipids Health Dis 2019 Mar 9;18(1):60. Epub 2019 Mar 9.

Clinic & Chair of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk, Poland.

Background: Chronic kidney disease (CKD) associates with complex lipoprotein disturbances resulting in high cardiovascular risk. Apolipoprotein E (APOE) is a polymorphic protein with three common isoforms (E2; E3; E4) that plays a crucial role in lipoprotein metabolism, including hepatic clearance of chylomicrons and very low-density lipoprotein (VLDL) remnants, and reverse cholesterol transport. It demonstrates anti-atherogenic properties but data concerning the link between polymorphism and level of APOE in CKD patients are inconclusive. Read More

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http://dx.doi.org/10.1186/s12944-019-1003-xDOI Listing
March 2019
1 Read

Triglyceride, fatty acid profile and antioxidant characteristics of low melting point fractions of Buffalo Milk fat.

Lipids Health Dis 2019 Mar 9;18(1):59. Epub 2019 Mar 9.

Department of Dairy Technology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.

Background: Among the dietary lipids, milk fat is most complicated as it contains more than one hundred types of fatty acids and several triglycerides. Huge versatility in triglyceride and fatty composition makes it possible to convert milk fat into various fractions on the basis of melting characteristics. Functional properties of milk fat can be increased by converting it into different fractions. Read More

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http://dx.doi.org/10.1186/s12944-019-0995-6DOI Listing

Monoraphidium sp. HDMA-20 is a new potential source of α-linolenic acid and eicosatetraenoic acid.

Lipids Health Dis 2019 Mar 4;18(1):56. Epub 2019 Mar 4.

Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Sciences, Heilongjiang University, Harbin, People's Republic of China.

Background: ω-3 polyunsaturated fatty acids (PUFAs) are synthesized from α-Linolenic acid (ALA, C18:3ω3) and play important roles in anti-inflammatory and antioxidant responses in mammal cells. ALA is an essential fatty acid which cannot be produced within the human body and must be acquired through diet. The purpose of this study was to evaluate the potential of a novel microalgal strain (HDMA-20) as a source of ω-3 PUFAs including ALA and eicosatetraenoic acid (ETA, C20:4ω3). Read More

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http://dx.doi.org/10.1186/s12944-019-0996-5DOI Listing
March 2019
2 Reads

Estimated glomerular filtration rate and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study.

Lipids Health Dis 2019 Mar 4;18(1):57. Epub 2019 Mar 4.

Department of Immunology and Microbiology, Guiyang College of Traditional Chinese Medicine, 84# ShiDong Road, Guiyang, 550001, Guizhou, China.

Background: Evidence regarding the relationship between estimated glomerular filtration rate (eGFR) and arterial stiffness is limited, and the data analysis is not sufficient to clarify the true relationship between the two. We aimed to investigate the relationship between eGFR and brachial-ankle pulse wave velocity (baPWV) in Japanese.

Methods: The present study was a cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12944-019-0997-4DOI Listing

Serum lipid and lipoprotein levels of middle-aged and elderly Chinese men and women in Shandong Province.

Lipids Health Dis 2019 Mar 4;18(1):58. Epub 2019 Mar 4.

Department of Endocrinology, The Second Hospital of Shandong University, 247 Beiyuan Street, Ji'nan, Shandong, 250033, People's Republic of China.

Background: Cardiovascular and cerebrovascular diseases have become leading causes of death in China as the economy develop and lifestyles change. This study aimed to estimate the relationship of the age, gender, and glucose metabolism with the serum lipid and lipoprotein levels of middle-aged and elderly Chinese men and women in Shandong Province.

Methods: We conducted a cross-sectional study in Shandong Province that included 10,028 adults aged ≥40 years. Read More

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http://dx.doi.org/10.1186/s12944-019-1000-0DOI Listing

Signature MicroRNA expression profile is associated with lipid metabolism in African green monkey.

Lipids Health Dis 2019 Feb 28;18(1):55. Epub 2019 Feb 28.

Laboratory Animal Center, the Academy of Military Medical Sciences, Beijing, 100071, People's Republic of China.

Background: Non-human primates (NHPs) are important models of medical research on obesity and cardiovascular diseases. As two of the most commonly used NHPs, cynomolgus macaque (CM) and African green monkey (AGM) own different capacities in lipid metabolism of which the mechanism is unknown. This study investigated the expression profiles of lipid metabolism-related microRNAs (miRNAs) in CM and AGM and their possible roles in controlling lipid metabolism-related gene expression. Read More

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http://dx.doi.org/10.1186/s12944-019-0999-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396449PMC
February 2019

Baricitinib induces LDL-C and HDL-C increases in rheumatoid arthritis: a meta-analysis of randomized controlled trials.

Lipids Health Dis 2019 Feb 18;18(1):54. Epub 2019 Feb 18.

Departement of Evidence-base Medcine and Clinical center, The First People's Hospital of Huaihua of University of South China, Huaihua, 418000, People's Republic of China.

Background: Baricitinib, an oral-administrated selective inhibitor of the JAK1 and JAK2, is recently approved for rheumatoid arthritis (RA) treatment. With the aim to provide some insights on the clinical safety, the current study mainly focused on the effect of baricitinib on low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular risk.

Methods: The net change scores [least squares mean (LSM) and mean change] of LDL-C and HDL-C levels from baseline with the comparison of baricitinib versus placebo were pooled, respectively. Read More

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http://dx.doi.org/10.1186/s12944-019-0994-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380020PMC
February 2019

Double bonds of unsaturated fatty acids differentially regulate mitochondrial cardiolipin remodeling.

Lipids Health Dis 2019 Feb 14;18(1):53. Epub 2019 Feb 14.

Department of Chemistry, Tunghai University, No.1727, Sec4, Taiwan Boulevard, Xitun District, Taichung, 40704, Taiwan, Republic of China.

Background: Supplemented fatty acids can incorporate into cardiolipin (CL) and affect its remodeling. The change in CL species may alter the mitochondrial membrane composition, potentially disturbing the mitochondrial structure and function during inflammation.

Method: To investigate the effect of the unsaturation of fatty acids on CL, we supplemented macrophage-like RAW264. Read More

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http://dx.doi.org/10.1186/s12944-019-0990-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376731PMC
February 2019
1 Read

κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.

Lipids Health Dis 2019 Feb 14;18(1):52. Epub 2019 Feb 14.

Department of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 West Changle Road, Xi'an, 710032, Shaanxi Province, China.

Background: This study was designed to test the hypothesis that κ-opioid receptor (κ-OR) stimulation reduces palmitate-induced HUVECs apoptosis and to investigate its mechanisms.

Methods: HUVECs were subjected to sodium palmitate, apoptosis and cell viability were determined, HUVECs were treated with specific inhibitors to PI3K, Akt, eNOS and siRNAs targeting κ-OR and Akt. Groups were divided as follows: the control group, the sodium palmitate group, the sodium palmitate+U50,488H (a selective κ-OR agonist) group and the sodium palmitate+U50,488H + nor-BNI (a selective κ-OR antagonist) group. Read More

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http://dx.doi.org/10.1186/s12944-019-0989-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376663PMC
February 2019
1 Read
2.219 Impact Factor

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study.

Lipids Health Dis 2019 Feb 12;18(1):50. Epub 2019 Feb 12.

Department of Maternal and Child Health, School of Public Health, and Global Health Institute (SGHI), Sun Yat-sen University, No.74 Zhongshan Road II, Guangzhou, 510080, Guangdong Province, China.

Background: Information on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk.

Method: In total, 1866 children and adolescents aged 7-18 were enrolled in this study, including 912 boys and 954 girls. Read More

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http://dx.doi.org/10.1186/s12944-019-0985-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371579PMC
February 2019
1 Read

Separate and combined associations of physical activity and obesity with lipid-related indices in non-diabetic and diabetic patients.

Lipids Health Dis 2019 Feb 12;18(1):49. Epub 2019 Feb 12.

Institute of Health Management, Chinese PLA General Hospital, No.28, Fuxing Road, Haidian District, Beijing, 100853, People's Republic of China.

Background: This study evaluated the separate and combined associations of physical activity and obesity with blood lipids in Chinese adults with and without diabetes.

Methods: Data of 17,535 participants aged 18 to 78 years old were collected. Physical activity was categorized as inactive (low) or active (moderate or high) according to the International Physical Activity Questionnaire. Read More

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http://dx.doi.org/10.1186/s12944-019-0987-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371482PMC
February 2019

Longitudinal changes of lipid profile in the Lebanese pediatric population.

Lipids Health Dis 2019 Feb 11;18(1):48. Epub 2019 Feb 11.

Endocrinology Department, Faculty of Medicine, Saint Joseph University, Saint-Joseph, Beirut, Lebanon.

Background: Few studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school-age children. Read More

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http://dx.doi.org/10.1186/s12944-019-0991-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371449PMC
February 2019
2 Reads

Total cholesterol to high-density lipoprotein cholesterol ratio is a significant predictor of nonalcoholic fatty liver: Jinchang cohort study.

Lipids Health Dis 2019 Feb 11;18(1):47. Epub 2019 Feb 11.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Basic Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China.

Background: Some studies found out that TC/HDL-C ratio is a predictor of Cardiovascular disease (CVD) and Nonalcoholic fatty liver (NAFLD) is related to CVD. And some researches have already studied that Apolipoprotein B to Apolipoprotein A1 ratio (ApoB/ApoA1) and Triglyceride to High-density lipoprotein cholesterol ratio (TG/HDL-C) were both related with CVD and NAFLD, but few studied the association between TC/HDL-C ratio and NAFLD. So, we suspected the ratio was also related to NAFLD. Read More

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http://dx.doi.org/10.1186/s12944-019-0984-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371543PMC
February 2019
1 Read
2.219 Impact Factor

Combining I148M and E167K variants to improve risk prediction for nonalcoholic fatty liver disease in Qingdao Han population, China.

Lipids Health Dis 2019 Feb 9;18(1):45. Epub 2019 Feb 9.

College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, 266003, China.

Background: PNPLA3 I148M variant and TM6SF2 E167K variant are recognized as the major genetic modifiers of nonalcoholic fatty liver disease (NAFLD). The present study sought to evaluate the potential additive effect of the two variants on the risk of NAFLD in Qingdao Han Population, China.

Methods: We genotyped PNPLA3 I148M variant and TM6SF2 E167K variant in a cohort of 512 unrelated NAFLD patients and 451 healthy controls by sequencing and polymerase chain reaction analysis. Read More

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http://dx.doi.org/10.1186/s12944-019-0992-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368685PMC
February 2019

Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway.

Lipids Health Dis 2019 Feb 9;18(1):46. Epub 2019 Feb 9.

Department of Otolaryngology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People's Republic of China.

Background: Intake of trans fatty acids (TFAs) from partially hydrogenated vegetable oil is associated with a variety of adverse outcomes, but little is known about the health effects of ruminant trans fats. Trans-vaccenic acid (TVA) is a naturally occurring TFA found in the fat of ruminants and in human dairy products. The present study was conducted to investigate the anticancer activity and underlying mechanisms of TVA on human nasopharyngeal carcinoma (NPC) 5-8F and CNE-2 cells. Read More

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http://dx.doi.org/10.1186/s12944-019-0993-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368753PMC
February 2019
1 Read

Lipectomy associated to obesity produces greater fat accumulation in the visceral white adipose tissue of female compared to male rats.

Lipids Health Dis 2019 Feb 9;18(1):44. Epub 2019 Feb 9.

Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Av. Marechal Campos 1468, Vitória, ES, CEP 29042-751, Brazil.

Background: Mobility of fat deposited in adipocytes among different fatty territories can play a crucial role in the pathogenesis of obesity-related diseases. Our goal was to investigate which of the remaining fat pads assume the role of accumulating lipids after surgical removal of parietal WAT (lipectomy; LIPEC) in rats of both sexes displaying MSG-induced obesity.

Methods: The animals entered the study straight after birth, being separated according to gender and randomly divided into CON (control, saline-treated) and MSG (monosodium glutamate-treated) groups. Read More

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http://dx.doi.org/10.1186/s12944-019-0988-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368803PMC
February 2019

Diabetic encephalopathy: beneficial effects of supplementation with fatty acids ω3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model.

Lipids Health Dis 2019 Feb 8;18(1):43. Epub 2019 Feb 8.

Biología Celular, Histología y Embriología. Facultad de Ciencias Médicas, INICSA CONICET-Universidad Nacional de Córdoba, Córdoba, Argentina.

Background: Diabetic encephalopathy is a chronic complications of diabetes mellitus that affects the central nervous system. We evaluated the effect of ω3 and ω6 polyunsaturated fatty acids (PUFAs) supplementation plus the antioxidant agent nordihydroguaiaretic acid (NDGA) on the etiopathology of diabetic encephalopathy in eSS rats, a spontaneous model of type 2 diabetes.

Methods: One hundred twenty spontaneous diabetic eSS male rats and 38 non-diabetic Wistar, used as healthy control, received monthly by intraperitoneal route, ω3 or ω6 PUFA (6. Read More

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http://dx.doi.org/10.1186/s12944-018-0938-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368734PMC
February 2019
1 Read

Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults.

Lipids Health Dis 2019 Feb 4;18(1):42. Epub 2019 Feb 4.

Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases, such as cardiovascular disease (CVD), metabolic syndrome, and breast and colon cancers, and shortens life expectancy. We aimed to determine the effects of moderate (MCT)- versus high-intensity interval training (HIT) on vascular function parameters in physically inactive adults. We hypothesized that individualized HIT prescription would improve the vascular function parameters more than the MCT in a greater proportion of individuals. Read More

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http://dx.doi.org/10.1186/s12944-019-0981-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362599PMC
February 2019
2 Reads

Antioxidant properties of Milk and dairy products: a comprehensive review of the current knowledge.

Lipids Health Dis 2019 Feb 4;18(1):41. Epub 2019 Feb 4.

Department of Meat Science and Technology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.

Milk and dairy products are integral part of human nutrition and they are considered as the carriers of higher biological value proteins, calcium, essential fatty acids, amino acids, fat, water soluble vitamins and several bioactive compounds that are highly significant for several biochemical and physiological functions. In recent years, foods containing natural antioxidants are becoming popular all over the world as antioxidants can neutralize and scavenge the free radicals and their harmful effects, which are continuously produced in the biological body. Uncontrolled free radicals activity can lead to oxidative stresses, which have been implicated in breakdown of vital biochemical compounds such as lipids, protein, DNA which may lead to diabetes, accelerated ageing, carcinogenesis and cardiovascular diseases. Read More

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http://dx.doi.org/10.1186/s12944-019-0969-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362592PMC
February 2019
1 Read
2.219 Impact Factor

Triglycerides to high-density lipoprotein cholesterol ratio as a surrogate for nonalcoholic fatty liver disease: a cross-sectional study.

Lipids Health Dis 2019 Feb 2;18(1):39. Epub 2019 Feb 2.

Department of Endocrinology and Metabolism, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.

Background: Triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) has been recommended as a surrogate marker for insulin resistance. In the present study, we aimed to investigate the relationship between TG/HDL-C and NAFLD in an apparently healthy population.

Methods: A total of 18,061 subjects who participated in a health checkup program were included. Read More

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http://dx.doi.org/10.1186/s12944-019-0986-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359827PMC
February 2019

Assessment of the LDL-C/HDL-C ratio as a predictor of one year clinical outcomes in patients with acute coronary syndromes after percutaneous coronary intervention and drug-eluting stent implantation.

Lipids Health Dis 2019 Feb 2;18(1):40. Epub 2019 Feb 2.

Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, 514031, People's Republic of China.

Background: Despite significant advances in the management of acute coronary syndromes (ACS), there are still plenty of patients undergoing percutaneous coronary intervention (PCI) and stent implantation suffered poor prognosis and high treatment expenditure. Evidence increasingly suggests that the ratio of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio might be a novel marker for the risk of atherosclerotic cardiovascular disease, but the impact of LDL-C/HDL-C ratio on 1-year prognosis of drug-eluting stent (DES) implantation patients after PCI is still not reported. Our aim of the study was to investigate the impact of LDL-C/HDL-C ratio on 1-year prognosis of DES implantation patients after PCI. Read More

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http://dx.doi.org/10.1186/s12944-019-0979-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359834PMC
February 2019
2 Reads

Untargeted Mass Spectrometry Lipidomics identifies correlation between serum sphingomyelins and plasma cholesterol.

Lipids Health Dis 2019 Feb 2;18(1):38. Epub 2019 Feb 2.

University Paris Descartes, 15 rue de l'Ecole de Médecine, 75006, Paris, France.

Background: Lipoproteins are major players in the development and progression of atherosclerotic plaques leading to coronary stenosis and myocardial infarction. Epidemiological, genetic and experimental observations have implicated the association of sphingolipids and intermediates of sphingolipid synthesis in atherosclerosis. We aimed to investigate relationships between quantitative changes in serum sphingolipids, the regulation of the metabolism of lipoproteins (LDL, HDL), and endophenotypes of coronary artery disease (CAD). Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
Publisher Site
http://dx.doi.org/10.1186/s12944-018-0948-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359757PMC
February 2019
13 Reads

Influence of total polar compounds on lipid metabolism, oxidative stress and cytotoxicity in HepG2 cells.

Lipids Health Dis 2019 Feb 1;18(1):37. Epub 2019 Feb 1.

School of Food Science and Technology, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, People's Republic of China.

Background: Recently, the harmful effects of frying oil on health have been gradually realized. However, as main components of frying oils, biochemical effects of total polar compounds (TPC) on a cellular level were underestimated.

Methods: The effects of total polar compounds (TPC) in the frying oil on the lipid metabolism, oxidative stress and cytotoxicity of HepG2 cells were investigated through a series of biochemical methods, such as oil red staining, real-time polymerase chain reaction (RT-PCR), cell apoptosis and cell arrest. Read More

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http://dx.doi.org/10.1186/s12944-019-0980-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359786PMC
February 2019

The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study.

Lipids Health Dis 2019 Jan 31;18(1):34. Epub 2019 Jan 31.

Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Objective: Metabolic syndrome (MS) is a group of risk factors which includes hypertension, hyperglycemia, abnormal cholesterol levels, and obesity. Red blood cell distribution width (RDW) is a parameter that reflects the heterogeneity of erythrocyte volume. But the relationship between MS and RDW is intricate and remains poorly understood. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0978-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357446PMC
January 2019
9 Reads
2.219 Impact Factor

Eicosapentaenoic acid/arachidonic acid ratio and weight loss during hospitalization for glycemic control among overweight Japanese patients with type 2 diabetes: a retrospective observational study.

Lipids Health Dis 2019 Jan 31;18(1):36. Epub 2019 Jan 31.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

Background: The study aimed to examine the relationship between levels of serum eicosapentaenoic acid (EPA), arachidonic acid (AA), as well as EPA/AA ratio and weight loss during hospitalization in participants considered to be overweight, with type 2 diabetes.

Methods: The study participants included 142 patients who were hospitalized for treatment of type 2 diabetes. We divided the participants into two groups depending on the achievenemt in reduction of bodyweight 3% or more during hospitalization and examined the relationship between serum levels of EPA and AA, as well as ratio of EPA/AA on admission and effectiveness of weight loss under strict dietary therapy during hospitalization, using Cox proportional hazard models. Read More

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http://dx.doi.org/10.1186/s12944-019-0983-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357375PMC
January 2019

Oxidative stability and Sensoric acceptability of functional fish meat product supplemented with plantbased polyphenolic optimal extracts.

Lipids Health Dis 2019 Jan 31;18(1):35. Epub 2019 Jan 31.

Department of Food Science, Nutrition & Home Economics, Government College University, Faisalabad, Pakistan.

Background: Fish meat and its products are usually accepted as good source of biological high value food components and especially for polyunsaturated fatty acids. The quality of fish meat products is considered to be decreased by the lipid peroxidation which leads to reduction in nutritional quality, financial loss and severe health problems. Many tactics are present to reserve their quality and safety. Read More

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http://dx.doi.org/10.1186/s12944-019-0982-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357494PMC
January 2019
2 Reads
2.219 Impact Factor

Influence of milling pH and storage on quality characteristics, mineral and fatty acid profile of buffalo Mozzarella cheese.

Lipids Health Dis 2019 Jan 29;18(1):33. Epub 2019 Jan 29.

Department of Dairy Technology, University of Veterinary and Animal Sciences, Lahore, 55300, Pakistan.

Background: Currently, cheese fat is a major component of human diet due to change in eating habits. It contains a number of health destroying as well as health promoting fatty acids. Bovine milk cheese fatty acid composition is regulating by many factors. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0976-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352441PMC
January 2019
5 Reads
2.219 Impact Factor

Blood pressure and low-density lipoprotein cholesterol control status in Chinese hypertensive dyslipidemia patients during lipid-lowering therapy.

Lipids Health Dis 2019 Jan 29;18(1):32. Epub 2019 Jan 29.

Department of Cardiology, Peking University People's Hospital, No. 11 Xizhimen South Street Xicheng District, Beijing, 100044, China.

ᅟ: The present study comprised 17,096 Chinese hypertensive dyslipidemia patients who received lipid-lowering treatment for > 3 months in order to investigate blood pressure (BP) as well as low-density lipoprotein cholesterol (LDL-C) goal attainment rates in Chinese hypertensive dyslipidemia patients on antidyslipidemia drugs. The factors that interfered with BP, or BP and LDL-C goal attainment rates and antihypertensive treatment patterns, were analyzed. In total, 89. Read More

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http://dx.doi.org/10.1186/s12944-019-0974-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352342PMC
January 2019
2 Reads
2.219 Impact Factor

Appropriate Total cholesterol cut-offs for detection of abnormal LDL cholesterol and non-HDL cholesterol among low cardiovascular risk population.

Lipids Health Dis 2019 Jan 26;18(1):28. Epub 2019 Jan 26.

Department of Family Medicine, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Road, Suthep, Muang, Chiang Mai, 50200, Thailand.

Background: Current guidelines suggest screening for dyslipidemia in early adulthood. In Thailand, a screening total cholesterol level is most commonly used potentially due to the costs of the test. However, the appropriate TC cut-off point that correlates with elevated low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (Non-HDL-C) levels for the low cardiovascular risk younger population have not been examined extensively in the literature. Read More

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http://dx.doi.org/10.1186/s12944-019-0975-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347761PMC
January 2019
1 Read

Association of 25-hydroxyvitamin D with HDL-cholesterol and other cardiovascular risk biomarkers in subjects with non-cardiac chest pain.

Lipids Health Dis 2019 Jan 26;18(1):27. Epub 2019 Jan 26.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Background: Chest pain is a serious symptom that is routinely investigated as a sign of coronary artery disease. Non-cardiac chest pain (NCCP) is indistinguishable from ischemic chest pain and both are considered serious and receive similar medical investigations. Although NCCP is not associated with cardiovascular diseases (CVDs), patients with NCCP may become anxious and frightened from developing coronary events. Read More

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http://dx.doi.org/10.1186/s12944-019-0961-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347766PMC
January 2019
3 Reads

Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial.

Lipids Health Dis 2019 Jan 26;18(1):31. Epub 2019 Jan 26.

Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, 305C Medical Science Building, Callaghan, NSW, 2308, Australia.

Background: Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D.

Methods: This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Read More

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http://dx.doi.org/10.1186/s12944-019-0967-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347796PMC
January 2019
3 Reads

Association between serum/plasma levels of adiponectin and obstructive sleep apnea hypopnea syndrome: a meta-analysis.

Lipids Health Dis 2019 Jan 26;18(1):30. Epub 2019 Jan 26.

The Key Laboratory of Upper Airway Dysfunction-Related Cardiovascular Diseases, Beijing Institute of Heart, Lung and Blood Vessel Diseases, No. 2 Anzhen Road, Beijing, 100029, China.

Background: The relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and a variety of disease from obesity, type 2 diabetes mellitus and cardiovascular disease has been investigated previously. Reduced adiponectin levels are also associated with increased risk of these disease. However, whether serum/plasma adiponectin levels in OSAHS patients are lower than their counterparts remain controversial. Read More

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http://dx.doi.org/10.1186/s12944-019-0973-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347767PMC
January 2019
2 Reads

Changes in lipids composition and metabolism in colorectal cancer: a review.

Lipids Health Dis 2019 Jan 26;18(1):29. Epub 2019 Jan 26.

Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.

Altered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites that differ in terms of their fatty acid composition. This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients' sera, tumor tissues and adipose tissue. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0977-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347819PMC
January 2019
8 Reads

Role of cholesterol and sphingolipids in brain development and neurological diseases.

Lipids Health Dis 2019 Jan 25;18(1):26. Epub 2019 Jan 25.

Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, Fujian Province, China.

Brain is a vital organ of the human body which performs very important functions such as analysis, processing, coordination, and execution of electrical signals. For this purpose, it depends on a complex network of nerves which are ensheathed in lipids tailored myelin; an abundant source of lipids in the body. The nervous system is enriched with important classes of lipids; sphingolipids and cholesterol which compose the major portion of the brain particularly in the form of myelin. Read More

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http://dx.doi.org/10.1186/s12944-019-0965-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347843PMC
January 2019
6 Reads
2.219 Impact Factor

Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.

Lipids Health Dis 2019 Jan 24;18(1):25. Epub 2019 Jan 24.

Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.

Background: Genetic variation in the genes ALOX5 (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) in Caucasian and African American populations. All genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly providing a link between MI and inflammation. The aim of the present study was to investigate whether these associations could be confirmed in the study of China MI patients. Read More

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http://dx.doi.org/10.1186/s12944-019-0968-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346589PMC
January 2019
1 Read

Exogenous supplement of N-acetylneuraminic acid improves macrophage reverse cholesterol transport in apolipoprotein E-deficient mice.

Lipids Health Dis 2019 Jan 24;18(1):24. Epub 2019 Jan 24.

Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, 150076, China.

Background: N-acetylneuraminic acid (NANA) is the major form of sialic acid in mammals, and the plasma NANA level is increased in patients with cardiovascular diseases. Exogenous supplement of NANA has been demonstrated to reduce hyperlipidaemia and the formation of atherosclerotic lesions; however, the underlying mechanisms have not yet been clarified. The aim of this study is to investigate whether exogenous supplement of NANA improves reverse cholesterol transprot (RCT) in vivo. Read More

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http://dx.doi.org/10.1186/s12944-019-0971-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346517PMC
January 2019
1 Read

The triglyceride paradox in the mortality of coronary artery disease.

Lipids Health Dis 2019 Jan 22;18(1):21. Epub 2019 Jan 22.

Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu, 610041, People's Republic of China.

Background: The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients.

Methods: A retrospective analysis was conducted from a single registered database. Read More

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http://dx.doi.org/10.1186/s12944-019-0972-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343235PMC
January 2019
2 Reads

Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis.

Lipids Health Dis 2019 Jan 22;18(1):23. Epub 2019 Jan 22.

Department of Health Sciences, Public University of Navarre, CIBERFES (CB16/10/00315), Pamplona, Navarre, Spain.

Background: Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults.

Methods: We searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. Read More

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http://dx.doi.org/10.1186/s12944-019-0962-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343360PMC
January 2019
1 Read

Circulating microRNA-92a level predicts acute coronary syndrome in diabetic patients with coronary heart disease.

Lipids Health Dis 2019 Jan 22;18(1):22. Epub 2019 Jan 22.

Medical Laboratory, Tianjin First Central Hospital, Tianjin, China.

Purpose: This study was designed to explore the value of monitoring miR-92a in T2DM patients with coronary heart disease (CHD).

Materials And Methods: 40 ACS patients with prior history of CHD and diabetes while the onset time of diabetes preceded that of CHD by more than 2 years were enrolled as the DACS group(diabetic ACS group). 40 ACS subjects who had had a definite diagnosis of CHD for more than 2 years with no history of T2DM were recuited as the CACS group(chronic CHD with ACS group). Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0964-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343303PMC
January 2019
7 Reads

Phospholipids in lipoproteins: compositional differences across VLDL, LDL, and HDL in pregnant women.

Lipids Health Dis 2019 Jan 22;18(1):20. Epub 2019 Jan 22.

LMU - Ludwig-Maximilians-Universität Munich, Div. Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, 80337, Munich, Germany.

Objective: The aim of this study was to analyse the differences in the phospholipid composition of very low density (VLDL), low density (LDL) and high density lipoprotein (HDL) monolayers in pregnant lean and obese women.

Methods: LDL, HDL, and VLDL were isolated from plasma samples of 10 lean and 10 obese pregnant women, and their species composition of phosphatidylcholines (PC) and sphingomyelins (SM) was analysed by liquid-chromatography tandem mass-spectrometry. Wilcoxon-Mann-Whitney U test and principal component analysis (PCA) were used to investigate if metabolite profiles differed between the lean/obese group and between lipoprotein species. Read More

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http://dx.doi.org/10.1186/s12944-019-0957-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343318PMC
January 2019

Are blood lipids associated with microvascular complications among type 2 diabetes mellitus patients? A cross-sectional study in Shanghai, China.

Lipids Health Dis 2019 Jan 18;18(1):18. Epub 2019 Jan 18.

Pudong Institute for Health Development, Shanghai, China.

Background: Although there are several studies to investigate the association between blood lipids and microvascular complications, these studies reported conflicting results. The aim of the current study was to explore the association between blood lipid parameters and the risk of microvascular complications, especially the dose-response association between them, among community patients with type 2 diabetes mellitus (T2DM) in Shanghai, China.

Methods: The cross-sectional study was conducted in 6 community health service centers in Shanghai between December 2014 and December 2016. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0970-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339385PMC
January 2019
11 Reads
2.219 Impact Factor

A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma.

Lipids Health Dis 2019 Jan 18;18(1):16. Epub 2019 Jan 18.

Department of Food Technology, University of Applied Science Fulda, Leipziger Str. 123, 36039, Fulda, Germany.

Background: The immune-modulating potential of long-chain polyunsaturated fatty acids (LCPUFAs) based on their conversion into lipid mediators in inflammatory situations has been proven by several studies. Respecting the immune-modulative role of lipid mediators in bronchoconstriction, airway inflammation and resolution of inflammatory processes, LCPUFAs play an important role in asthma. To design a disease-specific and most beneficial LCPUFA supplementation strategy, it is essential to understand how asthma alters LCPUFA profiles. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-018-0947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339374PMC
January 2019
5 Reads

Non-linear association of plasma level of high-density lipoprotein cholesterol with endobronchial biopsy bleeding in patients with lung cancer.

Lipids Health Dis 2019 Jan 18;18(1):17. Epub 2019 Jan 18.

Department of Laboratory Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province, 321000, China.

Background: Despite a large body of studies have demonstrated the multifaceted behavior of high-density lipoproteins (HDLs) in several physiological and pathological processes, the levels of plasma HDL-cholesterol (HDL-C) that may be associated with endobronchial biopsy (EBB)-related bleeding have never been examined.

Methods: We conducted a single-center retrospective cohort study of 628 consecutive patients with primary lung cancer who had undergone EBB at a large tertiary hospital between January 2014 and February 2018. Patients were divided into the bleeding group and the non-bleeding group according to the bronchoscopy report. Read More

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http://dx.doi.org/10.1186/s12944-019-0966-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339312PMC
January 2019

Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue.

Lipids Health Dis 2019 Jan 18;18(1):19. Epub 2019 Jan 18.

Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.

Background: Prenatal dexamethasone treatment has been shown to enhance the susceptibility of offspring to postnatal high-fat (HF) diet-induced programmed obesity. We investigated the metabolic phenotypes, nutrient-sensing signal and circadian-clock genes in adipose tissue that are programmed by prenatal dexamethasone exposure and postnatal HF diet.

Methods: Male offspring of Sprague-Dawley rats were divided into four experimental groups: normal diet, prenatal dexamethasone exposure, postnatal HF diet, and prenatal dexamethasone plus postnatal HF diet. Read More

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http://dx.doi.org/10.1186/s12944-019-0963-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339284PMC
January 2019
3 Reads
2.219 Impact Factor

Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement.

Lipids Health Dis 2019 Jan 17;18(1):15. Epub 2019 Jan 17.

Department of Physical Education, Pardis branch, Islamic Azad University, Pardis, Iran.

Background: Previous studies have shown that physical training and natural diet able to change the expression and concentration of peptides and proteins. Myokines and adipokines play an important role in metabolism and metabolic syndrome. Therefore, the purpose of the present study was to investigate the effect of high-intensity interval training (HIIT) and supplementation of flaxseed oil on plasma irisin, nesfatin-1 and resistin in male rats. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0960-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337839PMC
January 2019
9 Reads