7,697 results match your criteria Lipids [Journal]


Why We Care about Ethics and Ethical Publishing at Lipids.

Authors:
Eric J Murphy

Lipids 2019 Jan;54(1):3-4

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 1301 N. Columbia Rd., Grand Forks, ND 58201, USA.

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http://dx.doi.org/10.1002/lipd.12129DOI Listing
January 2019
1 Read

Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet.

Lipids 2019 Jan 14;54(1):81-97. Epub 2019 Feb 14.

DMEM (Dynamique Musculaire & Métabolisme) INRA, University of Montpellier, 2 Place Viala, 34060, Montpellier, France.

Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and oxidative stress during onset and progression of hepatic steatosis and glucose intolerance. Seventy-five male Wistar rats were divided to control and high-fat high-fructose (HFHFr) groups. Read More

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http://dx.doi.org/10.1002/lipd.12128DOI Listing
January 2019
2 Reads

Docosahexaenoic acid (22:6n-3) Ameliorated the Onset and Severity of Experimental Autoimmune Encephalomyelitis in Mice.

Lipids 2019 Jan 14;54(1):13-23. Epub 2019 Feb 14.

USDA, ARS, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.

Multiple sclerosis (MS) is a neurologic autoimmune disease, which is the leading cause of nontraumatic neurologic disability in young adults in United States and Europe. n-3 polyunsaturated fatty acids (PUFA) are reported to mitigate severity of this disease. Recent studies suggest that phospholipid (PL) form of dietary n-3 PUFA may lead to their higher tissue accretion than triacylglycerol (TAG) form. Read More

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http://dx.doi.org/10.1002/lipd.12130DOI Listing
January 2019
1 Read

n-3 Fatty Acids Abrogate Dyslipidemia-Induced Changes in Bile Acid Uptake, Synthesis, and Transport in Young and Aged Dyslipidemic Rats.

Lipids 2019 Jan 10;54(1):39-51. Epub 2019 Feb 10.

Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, Karnataka, India.

In this study, the effect of n-3 fatty acids (FA) [α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA)] on the intestinal bile acid (BA) uptake, hepatic BA synthesis, and enterohepatic bile acid transporters (BAT) was assessed in young and aged dyslipidemic rats. Dyslipidemia was induced in young and aged rats by feeding a high-fat (HF) diet. Experimental groups received diets containing canola oil (HF + CNO) and fish oil (HF + FO) as a source of ALA and EPA + DHA, respectively. Read More

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http://dx.doi.org/10.1002/lipd.12125DOI Listing
January 2019

Both Dietary Fatty Acids and Those Present in the Cecotrophs Contribute to the Distinctive Chemical Characteristics of New Zealand Rabbit Milk Fat.

Lipids 2018 Nov 10;53(11-12):1085-1096. Epub 2019 Feb 10.

Centro Nacional de Investigación Disciplinaria en Fisiología Animal, INIFAP, Ajuchitlán Colón, Qro 76280, México.

The relationship between the fatty acid (FA) profile of cecotrophs and that of the milk fat was evaluated in nine multiparous New Zealand does during the first 12 days of lactation. Milk samples were obtained manually on days 6, 8, 10, and 12 postpartum and cecotrophs and feces were collected on days 7, 9, and 11 postpartum. The FA profiles of feed, milk, cecotrophs, and feces were determined using gas chromatography. Read More

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http://dx.doi.org/10.1002/lipd.12127DOI Listing
November 2018

Combination of Dietary Ahiflower Oil and Equol Enhances Long-Chain Polyunsaturated Fatty Acid Levels in Rainbow Trout Tissues.

Lipids 2018 Nov 5;53(11-12):1069-1083. Epub 2019 Feb 5.

GMA - Gesellschaft für Marine Aquakultur mbH, Hafentörn 3, 25761, Büsum, Germany.

Equol and Ahiflower oil have been shown to increase either eicosapentaenoic acid (EPA, 20:5n-3) or docosahexaenoic acid (DHA, 22:6n-3) levels in tissues of rainbow trout when applied individually. Thus, we investigated whether the combination of an Ahiflower oil-based diet and equol might increase both, EPA and DHA levels, in rainbow trout. Rainbow trout (87. Read More

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http://dx.doi.org/10.1002/lipd.12117DOI Listing
November 2018
1 Read

Supplementation of All-Trans-Retinoic Acid Below Cytotoxic Levels Promotes Adipogenesis in 3T3-L1 Cells.

Lipids 2019 Jan 5;54(1):99-107. Epub 2019 Feb 5.

Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.

Vitamin A, referred to as retinol, is an essential nutrient that affects the cell growth and differentiation including adipogenesis. Although previous studies using supraphysiological doses (over 1 μM) of all-trans-retinoic acid (atRA) demonstrated antiadipogenic activity, effects of atRA at various levels on differentiation of 3T3-L1 preadipocytes have not been extensively investigated. Our study showed that the amount of cellular triacylglycerol (TAG) and intensities of Oil-Red-O staining were decreased by supplementing atRA (1 and 10 μM) but increased by low concentrations of atRA (0. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lipd.12123
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http://dx.doi.org/10.1002/lipd.12123DOI Listing
January 2019
3 Reads

Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways.

Lipids 2019 Jan 5;54(1):109-115. Epub 2019 Feb 5.

Gubra Aps, Hørsholm Kongevej 11B, 2970 Hørsholm, Denmark.

Simple steatosis is the hallmark of nonalcoholic fatty liver disease, with lipid accumulating as either microvesicular or macrovesicular lipid droplets within hepatocytes. The present study used a combination of laser capture microdissection and RNAseq to characterize murine gene expression in nonsteatotic, microsteatotic, and macrosteatotic compartments collected from the same liver. The data indicate that microvesicular steatosis is intermediate to macrovesicular steatosis, showing a widespread and pronounced metabolic gene regulation of lipid export, gluconeogenesis, and de novo lipogenesis. Read More

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http://dx.doi.org/10.1002/lipd.12121DOI Listing
January 2019
3 Reads

Leucine, Palmitate, or Leucine/Palmitate Cotreatment Enhances Myotube Lipid Content and Oxidative Preference.

Lipids 2018 Nov 31;53(11-12):1043-1057. Epub 2019 Jan 31.

Department of Exercise Science, High Point University, One University Pkwy, High Point, NC 27260, USA.

Branched-chain amino acids (BCAA) such as leucine stimulate favorable metabolic processes involved in lean tissue preservation and skeletal muscle metabolism. However, higher levels of circulating BCAA correlate with severity of metabolic disease (including diabetes/insulin resistance), and may result from dysregulated BCAA catabolism. Past observations have demonstrated potential interaction between BCAA and dietary fat; however, much of this relationship remains underexplored. Read More

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http://dx.doi.org/10.1002/lipd.12126DOI Listing
November 2018

Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells.

Lipids 2018 Nov 1;53(11-12):1021-1030. Epub 2019 Feb 1.

NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Nutrition and Movement Sciences, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.

Increasing apolipoprotein A-I (apoA-I), the predominant protein of high-density lipoprotein (HDL) particles, has favorable effects on atherogenic risk factors. Here, we investigated the effects of peroxisome proliferator-activated receptor α (PPARα) transactivating compounds on apoA-I transcription in HepG2 cells. A transient PPARα agonist transactivation assay was used to screen 2500 natural compounds. Read More

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http://dx.doi.org/10.1002/lipd.12116DOI Listing
November 2018

The Brain Oxylipin Profile Is Resistant to Modulation by Dietary n-6 and n-3 Polyunsaturated Fatty Acids in Male and Female Rats.

Lipids 2019 Jan 29;54(1):67-80. Epub 2019 Jan 29.

Department of Food and Human Nutritional Sciences, 190 Dysart Road, University of Manitoba Winnipeg, Canada R3T 2N2.

Oxylipins are bioactive lipids formed by the monooxygenation of polyunsaturated fatty acids (PUFA). Eicosanoids derived from arachidonic acid (ARA) are the most well-studied class of oxylipins that influence brain functions in normal health and in disease. However, comprehensive profiling of brain oxylipins from other PUFA with differing functions, and the examination of the effects of dietary PUFA and sex differences in oxylipins are warranted. Read More

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http://dx.doi.org/10.1002/lipd.12122DOI Listing
January 2019

Accretion of Dietary Docosahexaenoic Acid in Mouse Tissues Did Not Differ between Its Purified Phospholipid and Triacylglycerol Forms.

Lipids 2019 Jan 29;54(1):25-37. Epub 2019 Jan 29.

Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California Davis, 430 West Health Sciences Drive, Davis, CA 95616, USA.

Recent studies suggest that dietary krill oil leads to higher omega-3 polyunsaturated fatty acids (n-3 PUFA) tissue accretion compared to fish oil because the former is rich in n-3 PUFA esterified as phospholipids (PL), while n-3 PUFA in fish oil are primarily esterified as triacylglycerols (TAG). Tissue accretion of the same dietary concentrations of PL- and TAG-docosahexaenoic acid (22:6n-3) (DHA) has not been compared and was the focus of this study. Mice (n = 12/group) were fed either a control diet or one of six DHA (1%, 2%, or 4%) as PL-DHA or TAG-DHA diets for 4 weeks. Read More

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http://dx.doi.org/10.1002/lipd.12115DOI Listing
January 2019

Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation.

Lipids 2019 Jan 29;54(1):53-65. Epub 2019 Jan 29.

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Severe inflammatory disorders such as sepsis are a major cause of morbidity and mortality worldwide. Mitochondrial dysfunction is regarded as a key feature involved in inflammation pathogenesis. In the present study, we investigated the impact of the omega-3 fatty acid-derived lipid mediator Resolvin E1 (RvE1) on mitochondrial function in experimental pulmonary inflammation. Read More

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http://dx.doi.org/10.1002/lipd.12119DOI Listing
January 2019

The Importance of Ethics in Scientific Research.

Authors:
Regan Lawrence

Lipids 2019 Jan 29;54(1):5-7. Epub 2019 Jan 29.

University of North Dakota, Biomedical Sciences, Grand Forks, ND 58202, USA.

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http://dx.doi.org/10.1002/lipd.12118DOI Listing
January 2019

The Importance of Ethics in Scientific Research.

Lipids 2019 Jan 29;54(1):9-11. Epub 2019 Jan 29.

University of North Dakota, Grand Forks, ND, USA.

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http://dx.doi.org/10.1002/lipd.12120DOI Listing
January 2019

Diacylglycerol in Cationic Nanoparticles Stimulates Oxidative Stress-Mediated Death of Cancer Cells.

Lipids 2018 Nov 24;53(11-12):1059-1067. Epub 2019 Jan 24.

College of Veterinary Medicine, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.

Previous reports have suggested that cargo-free cationic nanoparticles (cNP) consisting of cationic monovalent lipids, such as 1,2-oleoyl-3-trimethylammonium-propane (DOTAP), induce reactive oxygen species (ROS) generation and toxicity in cells. In addition, cNP containing six lysine residues (6K) and cargo (6K-cNP) exerted synergistic effects on ROS production and cell death in cancer cells. In this study, we investigated the effect of diacylglycerol (DAG) derived from egg phosphatidylcholine in nanoparticles (NP) on ROS-mediated cellular toxicity. Read More

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http://dx.doi.org/10.1002/lipd.12124DOI Listing
November 2018
1 Read

Improvement of the Fourier Transform Near Infrared Method to Evaluate Extra Virgin Olive Oils by Analyzing 1,2-Diacylglycerols and 1,3-Diacylglycerols and Adding Unesterified Fatty Acids.

Lipids 2018 Nov 16;53(11-12):1097-1112. Epub 2019 Jan 16.

Guelph Food Research Center, Agriculture and Agri-Food Canada, Guelph, 10 Eringate Walk, Cambridge, Ontario, N1S 4Y6, Canada (Retired).

Extra virgin olive oils (EVOO) command higher prices because they contain health-promoting nutrients and desirable sensory characteristics. Many targeted methods have limited success in determining olive oil authenticity. Therefore, attention has been paid to rapid spectroscopic methods that provide the composition of multiple components. Read More

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http://dx.doi.org/10.1002/lipd.12113DOI Listing
November 2018

The Lentiviral System Construction for Highly Expressed Porcine Stearoyl-CoA Desaturase-1 and Functional Characterization in Stably Transduced Porcine Swine Kidney Cells.

Lipids 2018 Oct;53(10):933-945

Department of Animal Science, Texas A & M University, College Station, 2471 TAMU, TX 77843, USA.

The most highly regulated and abundant fatty acid in animal tissue is oleic acid (18:1n9). Oleic acid is synthesized by the Δ9 desaturase, stearoyl-CoA desaturase-1 (SCD1), which is responsible for the synthesis of the putative cytokine palmitoleic acid (16:1n7) and 18:2 cis-9, trans-11 conjugated linoleic acid. Owing to the importance of SCD1 in lipid metabolism, we generated porcine swine kidney (SK6) transgenic cell lines for sustained overexpression or knockdown of porcine stearoyl-CoA desaturase-1 (pSCD1) in an inducible manner by utilizing a lentiviral expression system. Read More

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http://dx.doi.org/10.1002/lipd.12102DOI Listing
October 2018
1.854 Impact Factor

Endothelial Lipase Is an Alternative Pathway for Fatty Acid Release from Lipoproteins: Evidence from a High Fat Diet Model of Obesity in Rats.

Lipids 2018 Oct;53(10):993-1003

Departamento de Bioquímica Clínica. Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956 (1113), Buenos Aires, Argentina.

Lipoprotein lipase (LPL) and endothelial lipase (EL) are involved in lipoprotein metabolism. In insulin-resistance, their behavior is altered. Peroxisome proliferator-activated receptors (PPAR) and apoproteins (apo)CII and CIII could be partly responsible for these alterations. Read More

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http://doi.wiley.com/10.1002/lipd.12107
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http://dx.doi.org/10.1002/lipd.12107DOI Listing
October 2018
10 Reads

Administration of Fenofibrate Markedly Elevates Fabp3 in Rat Liver and Plasma and Confounds Its Use as a Preclinical Biomarker of Cardiac and Muscle Toxicity.

Lipids 2018 Oct;53(10):947-960

Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA, 19104-4495, USA.

Proteins involved in lipid homeostasis are often regulated through the nuclear peroxisome proliferator-activated receptors (PPAR). PPARα is the target for the fibrate-class of drugs. Fenofibrate has been approved for its lipid-lowering effects in patients with hypercholesterolemia and hypertriglyceridemia. Read More

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http://dx.doi.org/10.1002/lipd.12110DOI Listing
October 2018

A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index.

Lipids 2018 Oct;53(10):1005-1015

School of Medicine and Lipid Research Centre, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia.

Omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) have several health benefits. In particular, low n-3 LCPUFA status is associated with cardiovascular disease (CVD) and led to the development of the omega-3 index that is the proportion of eicosapentaenoic acid and docosahexaenoic acid in the erythrocyte membranes, as a marker of CVD risk. Most methods used to measure the omega-3 index are laborious and time consuming. Read More

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http://dx.doi.org/10.1002/lipd.12108DOI Listing
October 2018

LipidomeDB Data Calculation Environment Has Been Updated to Process Direct-Infusion Multiple Reaction Monitoring Data.

Lipids 2018 Nov 21;53(11-12):1019-1020. Epub 2018 Dec 21.

Kansas Lipidomics Research Center, Division of Biology, Kansas State University, 1717 Claflin Road, Manhattan, KS 66506, USA.

LipidomeDB Data Calculation Environment (DCE), a web application for processing data from direct-infusion tandem mass spectrometer data on lipids, was described by Zhou et al. (, Lipids, 46, 879-884). The original version processed multiple precursor and/or neutral loss scans on multiple samples. Read More

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http://dx.doi.org/10.1002/lipd.12111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375751PMC
November 2018

Exogenous (Pomegranate Juice) or Endogenous (Paraoxonase1) Antioxidants Decrease Triacylglycerol Accumulation in Mouse Cardiovascular Disease-Related Tissues.

Lipids 2018 Nov 17;53(11-12):1031-1041. Epub 2018 Dec 17.

The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 1 Efron St. Haifa, Israel 31096.

The polyphenol-rich pomegranate juice (PJ) and the high-density lipoprotein (HDL)-associated paraoxonase1 (PON1) are known as potent atheroprotective antioxidants, but their effects on other tissues related to cardiovascular disease (CVD) remain unknown. The current study aimed to investigate the effects of treating mice with PJ or recombinant PON1 (rePON1) on the oxidation and lipid status of CVD-related tissues: serum, aorta, heart, liver, kidney, visceral, and subcutaneous adipose tissues (VAT and SAT). Both PJ consumption and rePON1 injection decreased the serum levels of thiobarbituric acid-reactive substances (16% and 19%) and triacylglycerols (TAG, 24% and 27%), while only rePON1 increased the levels of thiol groups (35%) and decreased serum cholesterol (15%). Read More

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http://doi.wiley.com/10.1002/lipd.12112
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http://dx.doi.org/10.1002/lipd.12112DOI Listing
November 2018
5 Reads

Projected Long-Chain n-3 Fatty Acid Intake Post-Replacement of Vegetables Oils with Stearidonic Acid-Modified Varieties: Results from a National Health and Nutrition Examination Survey 2003-2008 Analysis.

Lipids 2018 Oct 7;53(10):961-970. Epub 2018 Dec 7.

Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, 16802, USA.

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake is well below the amount recommended by the 2015-2020 Dietary Guidelines for Americans (0.25 g/day), supporting the need for alternative dietary sources. Stearidonic acid (SDA)-enriched soybeans were bioengineered to endogenously synthesize SDA, which can be readily metabolized to EPA in humans; thus, incorporating the derived SDA-enriched soybean oil into the food supply is a potential strategy to increase EPA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lipd.12105
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http://dx.doi.org/10.1002/lipd.12105DOI Listing
October 2018
20 Reads

Determination of the Phosphatidylcholine/Lysophosphatidylcholine Ratio in Intact Serum by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Prior Enzymatic Albumin Digestion.

Lipids 2018 Oct 28;53(10):971-977. Epub 2018 Nov 28.

Leibniz-Institut für Nutztierbiologie (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany.

Lysophosphatidylcholine (lysoPtdCho) is a well-known biomarker in body fluids for inflammation and oxidative stress and provides a possible clinical screening marker for certain diseases where inflammation is involved. It was shown in our previous article that the measurement of intact serum using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) provides the phosphatidylcholine (PtdCho)/lysoPtdCho ratios faster than the measurements after organic extraction, while the standard deviations of those "intact" measurements are even smaller. Surprisingly, the PtdCho/lysoPtdCho ratio is about two times higher in the intact serum MALDI-TOF MS measurement than in the MALDI-TOF MS analysis of the organic extracts. Read More

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http://dx.doi.org/10.1002/lipd.12106DOI Listing
October 2018
1 Read

Lipopolysaccharide Alters Thermogenic and Inflammatory Genes in White Adipose Tissue in Mice Fed Diets with Distinct 18-Carbon Fatty-Acid Composition.

Lipids 2018 Sep;53(9):885-896

Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN, 47907, USA.

Fatty acids are involved in the regulation of inflammatory responses in obesity. However, despite being the largest dietary fatty-acid class, effects of 18-carbon fatty acids with different degrees of saturation on inflammatory, metabolic, and thermogenic markers have not been well studied. Therefore, the objective of this study was to test if diets with different 18-carbon fatty-acid profiles differentially regulate inflammatory and metabolic genes. Read More

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http://dx.doi.org/10.1002/lipd.12101DOI Listing
September 2018
9 Reads

Unsaturated Fatty Acids Increase the Expression of Hepassocin through a Signal Transducer and Activator of Transcription 3-Dependent Pathway in HepG2 Cells.

Lipids 2018 Sep;53(9):863-869

Department of Family Medicine, National Cheng Kung University Hospital, National Cheng Kung University, No. 138, Sheng-Li, Road, 70403, Tainan, Taiwan.

Hepassocin (HPS) is a hepatokine that regulates hepatocyte proliferation. It is known that HPS plays an important role in the development of nonalcoholic fatty liver diseases (NAFLD). Fatty acids, such as oleic acid (OLA), exhibit the ability to activate the signal transducer and activator of transcription-3 (STAT3), and the binding site of STAT3 is found in the promoter region of HPS. Read More

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http://dx.doi.org/10.1002/lipd.12099DOI Listing
September 2018
19 Reads

Anandamide Induces Platelet Nitric Oxide Synthase through AMP-Activated Protein Kinase.

Lipids 2018 Sep;53(9):851-861

Department of Pharmacy, Biochemistry Lab, University of Genoa, Viale Benedetto XV 3, I-16132, Genoa, Italy.

The objective of this study was to determine whether adenosine 5' monophosphate (AMP)-activated protein kinase (AMPK) is activated by anandamide (AEA) and is involved in endothelial nitric oxide synthase (eNOS) activation. We found that AEA stimulates and activates AMPKα through a Ca -dependent/Calmodulin (CaM)-dependent pathway as the specific inhibitor of the Ca /Calmodulin kinase kinase β (CaMKKβ) STO-609 abolishes the AMPK phosphorylation/activation. The same inhibiting effect is shown in platelets pretreated with LY294002, an inhibitor of phosphatidylinositol 3 kinase (PI3K), or with MK2206, an inhibitor of protein kinase B (AKT), suggesting that AMPK is downstream of the PI3K/AKT pathway. Read More

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http://dx.doi.org/10.1002/lipd.12100DOI Listing
September 2018

Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes.

Lipids 2018 Sep;53(9):909-918

Department of Chemical Engineering, Dongguk University, 3-26, Pil-dong, Chung-gu, Seoul, 100-715, Republic of Korea.

Ceramide NP is known to be the most abundant class of 12 ceramide (CER) families that form a permeability barrier in the human skin barrier. However, not many studies have been reported on the regulation of the biosynthesis of ceramide NP. Recently, it has been reported that phytosphingosine (PHS) treatment in the cultured keratinocytes (KC) notably increased the content of ceramide NP. Read More

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http://dx.doi.org/10.1002/lipd.12097DOI Listing
September 2018
2 Reads

Relation of High-Density Lipoprotein Charge Heterogeneity, Cholesterol Efflux Capacity, and the Expression of High-Density Lipoprotein-Related Genes in Mononuclear Cells to the HDL-Cholesterol Level.

Lipids 2018 Oct 15;53(10):979-991. Epub 2018 Nov 15.

Institute of Molecular Genetics of the Russian Academy of Sciences, 2, Kurchatov Square, 123182, Moscow, Russia.

The heterogeneity and content of human plasma high-density lipoprotein (HDL) related to their atheroprotective properties determined by various molecular and cellular mechanisms still remain to be completely clarified. For 29 atherosclerosis-free male subjects, we studied the relationship of plasma lipid levels and the content of apolipoprotein A-I (apoA-I)-containing HDL with preβ-electrophoretic mobility, the efficiency of BODIPY-cholesterol efflux from RAW 264.7 macrophages to apolipoprotein B (apoB)-deficient plasma, and the expression level of 22 genes related to HDL metabolism in mononuclear cells. Read More

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http://doi.wiley.com/10.1002/lipd.12104
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http://dx.doi.org/10.1002/lipd.12104DOI Listing
October 2018
10 Reads

Cyp2b-Knockdown Mice Poorly Metabolize Corn Oil and Are Age-Dependent Obese.

Lipids 2018 Sep 12;53(9):871-884. Epub 2018 Nov 12.

Biological Sciences, Clemson University, 132 Long Hall St., Clemson, SC 29634, USA.

We previously made a RNAi-based cytochrome P450 2b (Cyp2b)-knockdown (Cyp2b-KD) mouse to determine the in vivo role of the Cyp2b subfamily in xenobiotic detoxification. Further studies reported here indicate a role for Cyp2b in unsaturated fatty-acid (UFA) metabolism and in turn obesity. Mice were treated intraperitoneally (i. Read More

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http://doi.wiley.com/10.1002/lipd.12095
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http://dx.doi.org/10.1002/lipd.12095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249079PMC
September 2018
9 Reads

A Simplified Gas Chromatographic Fatty-Acid Analysis by the Direct Saponification/Methylation Procedure and Its Application on Wild Tuna Larvae.

Lipids 2018 Sep 9;53(9):919-929. Epub 2018 Nov 9.

Pacific Bluefin Tuna Biology Group, Bluefin Tuna Resources Division, National Research Institute of Far Seas Fisheries, 5-7-1, Orido, Shimizu, Shizuoka, 424-8633, Japan.

A method for the direct preparation of fatty-acid methyl esters (FAME) was simplified for fatty-acid analysis of a single fish larva using gas chromatography (GC). The method included the isolation of a larval trunk and drying in a glass vial, followed by saponification of all the contents without prior lipid extraction. Thereafter, the fatty acids released were methylated by trimethylsilyldiazomethane. Read More

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http://doi.wiley.com/10.1002/lipd.12098
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http://dx.doi.org/10.1002/lipd.12098DOI Listing
September 2018
10 Reads

Triacylglycerol-Lowering Effect of Docosahexaenoic Acid Is Not Influenced by Single-Nucleotide Polymorphisms Involved in Lipid Metabolism in Humans.

Lipids 2018 Sep 8;53(9):897-908. Epub 2018 Nov 8.

Department of Foods and Human Nutritional Sciences, University of Manitoba, Dafoe Road, Winnipeg, MB R3T 2N2, Canada.

The triacylglycerol (TAG)-lowering effects of long-chain n-3 fatty acids, and in particular docosahexaenoic acid (DHA), are well documented, although these effects manifest large interindividual variability. The objective of this secondary analysis is to investigate whether common single-nucleotide polymorphisms (SNP) in genes involved in DHA synthesis and TAG metabolism are associated with the responsiveness of blood lipids, lipoprotein, and apolipoprotein concentration to dietary treatment by DHA supplied in high-oleic canola oil (HOCO). In a randomized, crossover-controlled feeding trial, 129 subjects with metabolic syndrome received high-oleic canola oil (HOCO) and high-oleic canola oil supplemented with DHA (HOCO-DHA), each for 4 weeks. Read More

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http://doi.wiley.com/10.1002/lipd.12096
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http://dx.doi.org/10.1002/lipd.12096DOI Listing
September 2018
11 Reads

Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty-Acid Oxidation Products and Reduces Anti-Inflammatory Products in Apolipoprotein E Mice.

Lipids 2018 Aug 22;53(8):785-796. Epub 2018 Oct 22.

School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR.

Oat bran is suggested to attenuate atherosclerotic conditions by regulating dyslipidemia, endothelial function, and oxidative damage. Through the measurement of oxidized polyunsaturated fatty acid (PUFA), oxidative stress, and inflammation status in liver and heart tissues of apolipoprotein E (ApoE ), mice fed with high fat diet (HFD) or HFD with oat bran (HFD + Oat) were investigated. Using liquid chromatography tandem mass spectrometry (LC-MS/MS), PUFA and over 40 types of its oxidized products were assessed. Read More

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http://doi.wiley.com/10.1002/lipd.12090
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http://dx.doi.org/10.1002/lipd.12090DOI Listing
August 2018
13 Reads

Detection of Endogenous Phosphatidylinositol 4,5-bisphosphate in Phytophthora cinnamomi.

Lipids 2018 Aug 17;53(8):835-839. Epub 2018 Oct 17.

School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia.

Plant diseases caused by Phytophthora species are serious threats to agriculture and the natural environment. Genome sequencing has revealed the lack of a gene for canonical phospholipase C (PLC), an enzyme that was hitherto thought to be ubiquitous in eukaryotes. PLC acts in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P ), a membrane-bound phospholipid critical for signal initiation in many cellular processes. Read More

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http://dx.doi.org/10.1002/lipd.12093DOI Listing
August 2018
2 Reads

Conjugated Linoleic Acid Regulates Body Composition and Locomotor Activity in a Sex-Dependent Manner in Drosophila melanogaster.

Lipids 2018 Aug 17;53(8):825-834. Epub 2018 Oct 17.

Department of Food Science, University of Massachusetts, 102 Holdsworth Way, Amherst, MA 01003, USA.

Conjugated linoleic acid (CLA) has been reported to be a bioactive food component. However, there is limited knowledge on the sex-dependent effects of CLA on energy metabolism. In the present study, Drosophila melanogaster was used to investigate the sex-dependent effects of CLA with respect to body fat, muscle, locomotion, and a key metabolic regulator, AMP-activated protein kinase α (AMPKα). Read More

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http://doi.wiley.com/10.1002/lipd.12091
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http://dx.doi.org/10.1002/lipd.12091DOI Listing
August 2018
3 Reads

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity.

Lipids 2018 Aug 17;53(8):767-784. Epub 2018 Oct 17.

Departments of Medicine and Pharmacology, The Pennsylvania State Cancer Institute, The Pennsylvania State College of Medicine, 500 University Drive Hershey, Hershey, PA 17033, USA.

The schweinfurthin family of compounds displays exciting potent and differential cytotoxicity against human cancer cell lines. Currently, the effect of schweinfurthins on tumor development and progression is being explored in animal models of cancer with promising results. The first schweinfurthin family member, vedelianin, was isolated in 1992, followed by other schweinfurthins in 1998. Read More

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http://dx.doi.org/10.1002/lipd.12088DOI Listing

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers.

Lipids 2018 Aug 17;53(8):797-807. Epub 2018 Oct 17.

Université de Lille 2, CNRS, CHU Lille, Institut Pasteur de Lille, UMR 8199 - EGID, Pôle recherche, 1 place de Verdun, Lille, 59045 Cedex, France.

It has been reported that polymorphisms within the gene-encoding enzymes related to alcohol metabolism are associated with levels of serum HDL-cholesterol (HDL-C) in East Asian populations. We evaluated the effects of genetic variants within the aldehyde dehydrogenase-2 (ALDH2) gene and the alcohol dehydrogenase-1B (ADH1B) gene on changes in the lipid profile in an 11-year longitudinal study. We genotyped rs1229984 within ADH1B and rs671 within ALDH2. Read More

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http://doi.wiley.com/10.1002/lipd.12087
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http://dx.doi.org/10.1002/lipd.12087DOI Listing
August 2018
1 Read

Dietary Buglossoides arvensis Oil as a Potential Candidate to Substitute Fish Oil in Rainbow Trout Diets.

Lipids 2018 Aug 17;53(8):809-823. Epub 2018 Oct 17.

GMA-Gesellschaft für Marine Aquakultur mbH, Hafentörn 3, 25761, Büsum, Germany.

The utilization of vegetable oils in salmonid diets substantially decreased the body content of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA), and thus the product quality for human consumption. Therefore, new ingredients for aquaculture feeds are needed that maximize the deposition of health-promoting n-3 LC-PUFA. This study investigated Buglossoides arvensis (Ahiflower) oil, a plant oil rich in alpha-linolenic acid (18:3n-3, ALA) and stearidonic acid (18:4n-3, SDA), as a source of n-3 fatty acids in rainbow trout (Oncorhynchus mykiss) nutrition. Read More

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http://doi.wiley.com/10.1002/lipd.12092
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http://dx.doi.org/10.1002/lipd.12092DOI Listing
August 2018
7 Reads

Diverse Odd-Chain Monoenoic Fatty Acids and Novel Non-Methylene-Interrupted Heptadecadienoic Acids in Ovaries of the Limpet Cellana toreuma.

Authors:
Hideki Kawashima

Lipids 2018 Aug 15;53(8):841-847. Epub 2018 Oct 15.

Bioscience Laboratory, Miyako College, Iwate Prefectural University, Miyako, Iwate, 027-0039, Japan.

Highly diverse dienoic fatty acids (FA), especially non-methylene-interrupted (NMI) FA, have been recognized in triacylglycerols (TAG) and polar lipids of ovaries of the limpet Cellana toreuma. To gain additional insights into the structural diversity of FA in ovaries, this study aimed to clarify previously undescribed minor monoenoic FA isomers and unidentified minor NMI FA by combined argentation thin-layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) of their 3-pyridylcarbinol derivatives. A total 66 monoenoic FA from C14 to C22, including 12 branched-chain FA, were identified. Read More

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http://doi.wiley.com/10.1002/lipd.12089
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http://dx.doi.org/10.1002/lipd.12089DOI Listing
August 2018
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Responses of MAC-T Cells to Inhibited Stearoyl-CoA Desaturase 1 during cis-9, trans-11 Conjugated Linoleic Acid Synthesis.

Lipids 2018 Jun;53(6):647-652

College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street no. 2888, Nanguan District, Changchun, 130118, Jilin Province, People' Republic of China.

Cis-9-conjugated, trans-11-conjugated linoleic acid (CLA) is known for its positive activities on human health. The synthesis of cis-9, trans-11 CLA in mammary glands is generally thought to be catalyzed by stearoyl-CoA desaturase 1 (SCD1), but this has not been rigorously established. In this study, we hypothesized that the inhibition of SCD1 (by CAY10566) would block the synthesis of cis-9, trans-11 CLA in bovine mammary alveolar cells (MAC-T) cells. Read More

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http://doi.wiley.com/10.1002/lipd.12077
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http://dx.doi.org/10.1002/lipd.12077DOI Listing
June 2018
9 Reads

Fucosterol Causes Small Changes in Lipid Storage and Brassicasterol Affects some Markers of Lipid Metabolism in Atlantic Salmon Hepatocytes.

Lipids 2018 Jul 27;53(7):737-747. Epub 2018 Sep 27.

Research group Requirement and Welfare, Institute of Marine Research, Nordnes gaten 50, 5005, Bergen, Norway.

Several feeding trials with Atlantic salmon fed naturally high phytosterol concentrations due to dietary rapeseed oil inclusion have shown changes in lipid metabolism and increased hepatic lipid storage in the fish. An in vitro trial with Atlantic salmon hepatocytes was, therefore, performed to study the possible direct effects of phytosterols on lipid storage and metabolism. The isolated hepatocytes were exposed to seven different sterol treatments and gene expression, as well as lipid accumulation by Oil Red O dyeing, was assessed. Read More

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http://doi.wiley.com/10.1002/lipd.12083
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http://dx.doi.org/10.1002/lipd.12083DOI Listing
July 2018
2 Reads

Conjugated Linoleic Acid Isomers Trans-10, Cis-12 and Cis-9, Trans-11 Prevent Collagen-Induced Arthritis in a Direct Comparison.

Lipids 2018 Jul 27;53(7):689-698. Epub 2018 Sep 27.

Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, 1400 University Ave Madison, WI, 53706, USA.

Mixed-isomer conjugated linoleic acid (CLA) and the individual isomers, trans-10, cis-12 (CLAt10c12) and cis-9, trans-11 (CLAc9t11), decrease severity of collagen-induced arthritis (CA) when consumed after disease onset. Few studies have been conducted exploring the role of CLA in the prevention of autoimmune diseases. These studies suggest that isomer-specific effects may be occurring; however, a direct comparison of CLAt10c12 and CLAc9t11 has yet to be conducted. Read More

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http://doi.wiley.com/10.1002/lipd.12082
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http://dx.doi.org/10.1002/lipd.12082DOI Listing
July 2018
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The Growth-Inhibiting Effects of Beef Fatty Acids on MCF-7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content.

Lipids 2018 Jul 26;53(7):699-708. Epub 2018 Sep 26.

Agriculture and Agri-Food Canada, Lacombe Research and Development Centre, 6000 C&E Trail, Lacombe, Alberta, T4L 1W1, Canada.

Biohydrogenation intermediates (BHI) including conjugated linoleic acid (CLA) isomers are formed during ruminal biohydrogenation of polyunsaturated fatty acids (PUFA) in ruminants. Although many studies have examined the anticarcinogenic effects of CLA, few studies have reported the anticarcinogenic properties of BHI in their natural form found in dairy and beef fats. The present study compared the growth-inhibitory effects of fatty acids from beef perirenal fat (PRF) or subcutaneous fat (SCF) with low or high levels of BHI in MCF-7 human breast cancer cells. Read More

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http://doi.wiley.com/10.1002/lipd.12085
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http://dx.doi.org/10.1002/lipd.12085DOI Listing
July 2018
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Dietary Fatty-Acid Compositions Are more Strongly Reflected in Fatty than Lean Dorsal Fillets of Common Carp (Cyprinus carpio L.).

Lipids 2018 Jul 25;53(7):727-735. Epub 2018 Sep 25.

Aquatic Lipid Research and Ecotoxicology (LIPTOX), WasserCluster Lunz - Biologische Station, Dr. Carl Kupelwieser Promenade 5, A-3293, Lunz am See, Austria.

In this fish-feeding study, we tested similarity patterns between fatty acids (FA) in diets and common carp (Cyprinus carpio) of fish ponds used for semi-intensive aquaculture, containing naturally occurring pond zooplankton and different feeds (marine or terrestrial feeds) until carp reached market size. We evaluated if and how total lipid contents in dorsal fillets can reflect dietary FA compositions in farm-raised common carp and hypothesized that increasing total lipid contents in dorsal fillets significantly increase the similarity between dietary and dorsal fillets' FA compositions. Results of this study showed that carps had higher total lipids when supplied with marine feeds and dietary FA compositions were indeed more strongly reflected in fatty (i. Read More

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http://doi.wiley.com/10.1002/lipd.12080
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http://dx.doi.org/10.1002/lipd.12080DOI Listing
July 2018
1 Read

Folic Acid Supplementation Attenuates Chronic Hepatic Inflammation in High-Fat Diet Fed Mice.

Lipids 2018 Jul 25;53(7):709-716. Epub 2018 Sep 25.

Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, MB, Canada.

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide. Hepatic inflammation is an important pathogenic mediator of NAFLD. There is currently no pharmacological agent approved for the treatment of NAFLD. Read More

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http://dx.doi.org/10.1002/lipd.12084DOI Listing
July 2018
4 Reads

Properties and Biotechnological Applications of Acyl-CoA:diacylglycerol Acyltransferase and Phospholipid:diacylglycerol Acyltransferase from Terrestrial Plants and Microalgae.

Lipids 2018 Jul 25;53(7):663-688. Epub 2018 Sep 25.

Department of Agricultural, Food and Nutritional Science, University of Alberta, 116 Street and 85 Avenue, Edmonton, Alberta, T6G 2P5, Canada.

Triacylglycerol (TAG) is the major storage lipid in most terrestrial plants and microalgae, and has great nutritional and industrial value. Since the demand for vegetable oil is consistently increasing, numerous studies have been focused on improving the TAG content and modifying the fatty-acid compositions of plant seed oils. In addition, there is a strong research interest in establishing plant vegetative tissues and microalgae as platforms for lipid production. Read More

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http://dx.doi.org/10.1002/lipd.12081DOI Listing
July 2018
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Presence of Fatty-Acid Ethyl Esters in Krill Oil Dietary Supplements.

Lipids 2018 Jul 23;53(7):749-754. Epub 2018 Sep 23.

Center for Food Safety and Applied Nutrition (CFSAN), United States Food and Drug Administration (FDA), 5001 Campus Drive, College Park, MD, 20740, USA.

Krill oil dietary supplements are increasingly used for their high concentrations of phospholipids (PL), which offer reportedly greater bioavailability of n-3 polyunsaturated fatty acids (PUFA) than those of triacylglycerols or fatty-acid ethyl esters (FAEE) commonly found in fish oils and fish-oil concentrates. This work evaluated the lipid composition of 22 commercial krill oil (CKO) supplements available in the US market, and found ten products (i.e. Read More

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http://dx.doi.org/10.1002/lipd.12078DOI Listing
July 2018
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Determination of Iodine Value in Hydrogenated Oils: Comparison of Titration and Gas Chromatography with Flame-Ionization Detection Methodologies.

Lipids 2018 Jul 19;53(7):755-763. Epub 2018 Sep 19.

Center for Food Safety and Applied Nutrition (CFSAN), United States Food and Drug Administration, 5001 Campus Drive, College Park, MD, 20740, USA.

The United States Food and Drug Administration (FDA) recently issued its final determination that partially hydrogenated oils (PHO) are no longer generally recognized as safe (GRAS) for any use in human food. Consequently, the discrimination between PHO and fully hydrogenated oils (FHO), which is achieved by the iodine value (IV), has become an important regulatory issue. This study compared American Oil Chemists' Society (AOCS) and International Organization for Standardization (ISO) titration and gas chromatography with flame-ionization detection (GC-FID) methodologies for the determination of IV in seven samples of hydrogenated oil, namely coconut, cottonseed (n = 2), palm kernel, palm stearine, and soybean (n = 2) oils. Read More

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http://dx.doi.org/10.1002/lipd.12079DOI Listing

Sphingolipidomics of Thermotolerant Yeasts.

Lipids 2018 Jun 12;53(6):627-639. Epub 2018 Sep 12.

Lab of Fungal Genetics and Metabolism, Institute of Microbiology of the CAS, v.v.i, Vídeňská 1083, 142 20, Prague, Czech Republic.

Mass spectrometry-based shotgun lipidomics was applied to the analysis of sphingolipids of 11 yeast strains belonging to four genera, that is Cryptococcus, Saccharomyces, Schizosaccharomyces, and Wickerhamomyces. The analysis yielded comprehensive results on both qualitative and quantitative representation of complex sphingolipids of three classes-phosphoinositol ceramide (PtdInsCer), mannosyl inositol phosphoceramide (MInsPCer), and mannosyl diinositol phosphoceramide (M(InsP) Cer). In total, nearly 150 molecular species of complex sphingolipids were identified. Read More

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http://doi.wiley.com/10.1002/lipd.12076
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http://dx.doi.org/10.1002/lipd.12076DOI Listing
June 2018
8 Reads