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The Atrial Fibrillation Better Care pathway for managing atrial fibrillation: a review.

Europace 2021 Jun 14. Epub 2021 Jun 14.

Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool Heart & Chest Hospital, 6 West Derby Street, Liverpool L7 8TX, UK.

The 2020 European Society of Cardiology guidelines endorse the Atrial Fibrillation Better Care (ABC) pathway as a structured approach for the management of atrial fibrillation (AF), addressing three principal elements: 'A' - avoid stroke (with oral anticoagulation), 'B' - patient-focused better symptom management, and 'C' - cardiovascular and comorbidity risk factor reduction and management. This review summarizes the definitions used for the ABC criteria in different studies and the impact of adherence/non-adherence on clinical outcomes, from 12 studies on seven different cohorts. All studies consistently showed statistically significant reductions in the risk of stroke, myocardial infarction, and mortality among those with ABC pathway adherent treatment. Read More

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Effect of portable non-invasive ventilation on thoracoabdominal volumes in recovery from intermittent exercise in patients with COPD.

J Appl Physiol (1985) 2021 Jun 10. Epub 2021 Jun 10.

Department of Sport, Exercise and Rehabilitation, grid.42629.3bNorthumbria University, Newcastle Upon-Tyne, United Kingdom.

Background: We previously showed that use of portable non-invasive ventilation (pNIV) during recovery periods within intermittent exercise improved breathlessness and exercise tolerance in COPD patients compared to pursed-lip breathing (PLB). However, in a minority of patients recovery from dynamic hyperinflation (DH) was better with PLB, based on inspiratory capacity. We further explored this using Optoelectronic Plethysmography to assess total and compartmental thoracoabdominal volumes. Read More

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Dental implant placement with inferior alveolar nerve repositioning in severely resorbed mandibles: a retrospective multicenter study of implant success and survival rates, and lower lip sensory disturbances.

Int J Implant Dent 2021 Jun 9;7(1):44. Epub 2021 Jun 9.

S'OS Orthognathic Surgery, Vytenio 22-201, Vilnius, Lithuania.

Background: The purpose of this study was to analyze medium-to-long-term implant success and survival rates, and lower lip sensory disturbance after placement of dental implants with simultaneous inferior alveolar nerve (IAN) repositioning.

Methods: Fifteen patients (3 men, 12 women) treated in two centers were included in this retrospective study. The ages of the participants ranged from 19 to 68. Read More

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Premature Mortality Due to Tobacco-Related Malignancies in Poland.

Int J Gen Med 2021 31;14:2171-2182. Epub 2021 May 31.

Department of Epidemiology and Hygiene, Chair of Social Medicine, Poznan University of Medical Sciences, Poznan, 60-806, Wielkopolska, Poland.

Introduction: Although in Poland at the turn of the 20th and 21st centuries, tobacco consumption per capita was one of the highest in the world as a result of specific political and social conditions, nicotinism was the most common preventable cause of death that reduced life expectancy by 10 years on average. The aim of this study is to determine the level of premature mortality and its trends by age and sex for tobacco-related malignancies in Poland in the years 2008-2017.

Methods: The standardised premature mortality rates as well as mortality rates for five-year age ranges according to the patients' sex were used. Read More

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[Global oral health in the international health policy spotlight-challenges and new opportunities for sustainable improvement].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Jun 8. Epub 2021 Jun 8.

Lehrstuhl für Quality and Safety of Oral Health Care, Department of Dentistry, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Niederlande.

Oral diseases are a significant global health problem across all countries and populations. With about 3.5 billion cases (2017), more people are affected than by any other disease group. Read More

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Comparison of treatment effects from total arch distalization using modified C-palatal plates versus maxillary premolar extraction in Class II patients with severe overjet.

Orthod Craniofac Res 2021 Jun 4. Epub 2021 Jun 4.

Department of Orthodontics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Introduction: This study aimed to compare the skeletodental and soft tissue changes with total arch distalization using a modified C-palatal plate (MCPP) and maxillary first premolar extraction treatment in Class II malocclusion patients with severe overjet.

Setting And Sample Population: The sample consisted of 46 adult patients who had Class II Division 1 malocclusion with severe overjet; 25 of them received non-extraction treatment with MCPPs (age, 22.5 ± 7. Read More

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A systematic analysis of surgical interventions for the airway in the mature unilateral cleft lip nasal deformity: a single case study.

Int J Comput Assist Radiol Surg 2021 Jun 2. Epub 2021 Jun 2.

Duke University Medical Center, Duke University Hospital, Durham, NC, USA.

Purpose: Individuals with unilateral cleft lip nasal deformity (uCLND) often require rhinoplasty in adolescence to correct nasal obstruction. The intent of this study is to identify sites of greatest nasal obstruction and evaluate the effects of isolated and combinations of simulated surgical procedures on these sites using computational fluid dynamics (CFD).

Methods: Computed tomography imaging of an adolescent subject with uCLND was converted to an anatomically accurate three-dimensional nasal airway model. Read More

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Glucose and Triphenylphosphonium Co-Modified Redox-Sensitive Liposomes to Synergistically Treat Glioma with Doxorubicin and Lonidamine.

ACS Appl Mater Interfaces 2021 Jun 1;13(23):26682-26693. Epub 2021 Jun 1.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Glioma is one of the most lethal and complex tumors, and thus, an effective drug delivery system must selectively target the tumor sites and release its cargos in a controlled manner. For the first time, we combined chemotherapeutic agent doxorubicin (DOX) and chemosensitizer lonidamine (LND) to synergistically treat glioma. We also designed and prepared multitargeted redox-sensitive liposomes (Lip-SPG) co-modified with glucose and triphenylphosphonium (TPP) to effectively deliver DOX and LND for anti-glioma therapy. Read More

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The effect of sex on the efficacy and safety of dual antithrombotic therapy with dabigatran versus triple therapy with warfarin after PCI in patients with atrial fibrillation (a RE-DUAL PCI subgroup analysis and comparison to other dual antithrombotic therapy trials).

Clin Cardiol 2021 May 27. Epub 2021 May 27.

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: The RE-DUAL PCI trial demonstrated that in patients with nonvalvular atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), dual therapy with dabigatran and a P2Y inhibitor, either clopidogrel or ticagrelor, reduced the risk of bleeding without an increased risk of thromboembolic events as compared to triple therapy with warfarin in addition to a P2Y inhibitor and aspirin. What remains unclear is whether this effect is consistent between males and females undergoing PCI.

Hypothesis: The reduction in risk of bleeding without increased risk of thromboembolic events with dual therapy with dabigatran and a P2Y inhibitor in comparison to triple therapy with warfarin, a P2Y inhibitor and aspirin is consistent in females and males. Read More

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Comparisons of costs and treatment effects-an RCT on headgear activator treatment of excessive overjet in the mixed and late mixed dentition.

Eur J Orthod 2021 May 27. Epub 2021 May 27.

Department of Orthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.

Objectives: To compare the costs and treatment effects of headgear activator treatment of Class II malocclusion with excessive overjet between treatments started in the mixed (MD) and late mixed dentition (LMD).

Trial Design: Two-arm parallel-group single-centre randomized controlled trial (RCT).

Material And Methods: A total of 56 children presenting Class II malocclusion with excessive overjet were assessed and invited to an RCT designed as intention-to-treat. Read More

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Graphene environmental biodegradation: Wood degrading and saprotrophic fungi oxidize few-layer graphene.

J Hazard Mater 2021 07 1;414:125553. Epub 2021 Mar 1.

Department of Life Sciences, University of Trieste, via L. Giorgieri 10, Trieste I-34127, Italy.

The environmental biodegradability profile of graphene related materials (GRMs) is important to know in order to predict whether these materials will accumulate in soil or will be transformed by primary decomposers. In this study, few-layer graphene (FLG) was exposed to living and devitalized axenic cultures of two white-rot basidiomycetes (Bjerkandera adusta and Phanerochaete chrysosporium) and one soil saprotrophic ascomycete (Morchella esculenta) with or without lignin, for a period of four months. Over this time, the increase of fungal biomass and presence of HO and oxidizing enzymes [laccase/peroxidase and lignin peroxidase (LiP)] in growth media was assessed by gravimetric and spectrophotometric measurements, respectively. Read More

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Adherence to the 'Atrial Fibrillation Better Care' (ABC) Pathway in Patients with Atrial Fibrillation.

Thromb Haemost 2021 May 21. Epub 2021 May 21.

Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy.

Aims: The 'Atrial Fibrillation Better Care' (ABC) pathway has been recently proposed as a holistic approach for the comprehensive management of patients with Atrial Fibrillation (AF). We performed a systematic review of current evidence for the use of the ABC pathway on clinical outcomes.

Methods And Results: We performed a systematic review and meta-analysis according to PRISMA Guidelines. Read More

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Repair of Asymmetric Bilateral Cleft lip: 1 Stage or 2 Stage.

Cleft Palate Craniofac J 2021 May 21:10556656211013978. Epub 2021 May 21.

Department of Oral & Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Oral Diseases Clinical Research Center, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, China.

Objective: To verify the advantages and indications of 1-stage and 2-stage repair for asymmetric bilateral cleft lip (BCL).

Design: Retrospective study.

Setting: From January 2004 to December 2016 in our department. Read More

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A causal role for the pulvinar in coordinating task-independent cortico-cortical interactions.

J Comp Neurol 2021 May 19. Epub 2021 May 19.

Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.

The pulvinar is the largest nucleus in the primate thalamus and has topographically organized connections with multiple cortical areas, thereby forming extensive cortico-pulvino-cortical input-output loops. Neurophysiological studies have suggested a role for these transthalamic pathways in regulating information transmission between cortical areas. However, evidence for a causal role of the pulvinar in regulating cortico-cortical interactions is sparse and it is not known whether pulvinar's influences on cortical networks are task-dependent or, alternatively, reflect more basic large-scale network properties that maintain functional connectivity across networks regardless of active task demands. Read More

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A novel diagnostic technique of measuring labial minor salivary gland secretions using sodium fluorescein dye: Implications for patients with dry eyes.

Semin Ophthalmol 2021 May 16:1-6. Epub 2021 May 16.

Center for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, Telangana, India.

: To evaluate the lower labial minor salivary glands (MSGs) flow rate using fluorescein dye in healthy individuals and patients with Sjögren's syndrome (SS) and Stevens-Johnson syndrome (SJS).: Thirty consecutive patients with SS ( = 15; mean age 35.7 years) and SJS ( = 15; 57. Read More

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E-Cigarette Burns and Explosions: What are the Patterns of Oromaxillofacial Injury?

J Oral Maxillofac Surg 2021 Mar 29. Epub 2021 Mar 29.

William Beaumont Hospital - Royal Oak, Department of Otolaryngology, Royal Oak, MI.

Purpose: With the recent increase in popularity of electronic cigarette use in the United States, its harmful effects are not only limited to smoke inhalation, but also to the possibility of e-cigarette device malfunction. The purpose of this review is to characterize oromaxillofacial trauma secondary to electronic cigarette device explosion.

Methods: For this systematic review, PubMed and Embase were searched in October 2019 using the following search terms: e-cigarette burns, e-cigarette injury, and e-cigarette explosions, which yielded 400 studies. Read More

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The Anti-Cancer Effect of Pitavastatin May Be a Drug-Specific Effect: Subgroup Analysis of the TOHO-LIP Study.

Vasc Health Risk Manag 2021 28;17:169-173. Epub 2021 Apr 28.

Department of Internal Medicine, Mihama Hospital, Chiba, Japan.

The significance of statin treatment for the reduction of cardiovascular (CV) disease has been reported, whereas other reports have also described anti-cancer properties associated with the class effect of statins. However, the differences in anti-cancer effect of various types of statins have rarely been examined. Pitavastatin is a statin with a different chemical structure and pharmacokinetics from other statins, and the mechanism of the specific anti-cancer effect of pitavastatin has been reported in in vivo therapeutic models. Read More

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Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review.

Age Ageing 2021 May;50(3):744-757

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Background: anticoagulation is integral to stroke prevention for atrial fibrillation (AF), but there is evidence of under-treatment in older people in long-term care (LTC).

Objective: to synthesise evidence on the prevalence and outcomes (stroke, mortality or bleeding) of AF in LTC and the factors associated with the prescription of anticoagulation.

Methods: studies were identified from Medline, CINAHL, PsycINFO, Scopus and Web of Science from inception to 31 October 2019. Read More

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The effect of botulinum toxin A in patients with excessive gingival display with and without zinc supplementation: randomized clinical trial.

Clin Oral Investig 2021 May 5. Epub 2021 May 5.

Department of Oral Medicine and Periodontology, Faculty of Dentistry Cairo University, Cairo, Egypt.

Objective: The objective is to determine the effect of oral zinc supplement intake on the clinical efficacy and sustained effect of BTXA injection, in patients with excessive gingival display (EGD).

Materials And Methods: Twenty-five participants with excessive gingival display (EGD) were included in this parallel-group RCT, treated with BTXA with and without Zinc supplementation prior to treatment. Participants were assessed for excessive gingival display reduction and results of stability at 2, 6, 12, 18, and 24 weeks. Read More

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Comparing Effectiveness of Three Different Anti-VEGF Treatment Regimens for Neovascular Age-Related Macular Degeneration: Two Years' Real-World Clinical Outcomes.

Clin Ophthalmol 2021 23;15:1703-1713. Epub 2021 Apr 23.

Birmingham & Midland Eye Centre, Birmingham, UK.

Purpose: To compare and report the 2-year treatment outcomes from 3 different anti-VEGF treatment regimens in treating neovascular aged-related macular degeneration (nAMD): Ranibizumab pro re nata (Ranibizumab-PRN); Ranibizumab treat and extend (Ranibizumab-T&E); Aflibercept fixed first year dosing (7 injections) with treat and extend in subsequent year (Aflibercept-Fixed).

Methods: All treatment-naïve nAMD patients who completed 24 months of monitoring from a single treatment center were included. Patients received the initial loading dose of three injections (4-weekly interval), followed by one of the 3 treatment regimens. Read More

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Paying lip service to publication ethics: scientific publishing practices and the Foundation for a Smoke-Free World.

Tob Control 2021 Apr 28. Epub 2021 Apr 28.

Tobacco Control Research Group, Department for Health, University of Bath, Bath, UK.

Litigation forced the dissolution of three major tobacco industry-funded organisations because of their egregious role in spreading scientific misinformation. Yet in 2017, a new scientific organisation-the Foundation for a Smoke-Free World (FSFW)-was launched, funded entirely by tobacco corporation Philip Morris International (PMI). Experts fear FSFW similarly serves to benefit its funder's scientific and political agenda. Read More

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Orthodontic Pre Grafting Closure of Large Alveolar Bony and Soft Tissue Gaps: A Novel Nonsurgical Protraction of the Lesser Segments in Growing Patients With Cleft Lip and Palate.

Cleft Palate Craniofac J 2021 Apr 13:10556656211007697. Epub 2021 Apr 13.

Department of Maxillo Facial Surgery, Santi Paolo and Carlo Hospital, Milan, Italy.

Background: Closure of wide alveolar clefts with large soft tissue gaps and reconstruction of the dentoalveolar defect are challenging for the surgeon. Some authors successfully used interdental segmental distraction, which requires an additional surgical procedure.

Objective: This study evaluates the effectiveness of tooth borne devices utilized to orthopedically advance the lesser segments, with a complete approximation of the soft tissue of the alveolar stumps, allowing traditional simultaneous soft tissue closure and bone grafting, and avoiding the need for supplementary surgery. Read More

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[Molybdenum cofactor deficiency caused by gene mutation: a case report].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):416-419

Department of Neurology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

A boy attended the hospital at the age of 1 month due to left hand tremor for 1 week. A blood test showed a reduction in serum uric acid and a cranial MRI showed encephalomalacia, atrophy, and cystic changes. The boy had microcephalus, unusual facial features (long face, long forehead, protruded forehead, long philtrum, low nasal bridge, facial swelling, and thick lower lip), hypertonia of lower extremities, and severe global developmental delay. Read More

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The Rhino-Lip-Lifting: A Novel Proposal for Midface Profileplasty Performed as a Single Surgical Procedure.

Facial Plast Surg 2021 Jun 8;37(3):340-347. Epub 2021 Apr 8.

Department of Facial Plastic Surgery, Rigeneralab Center for Regenerative Medicine, Torino, Italy.

As facial aging occurs, aesthetic changes of the nasal tip and the senile upper lip include tip ptosis, increase in skin length, loss of vermillion height and Cupid's bow, and vertical wrinkles.Regardless of the rejuvenation procedure, the lips are not to be considered as a single anatomical entity, instead they should be placed in a strong correlation with the nose. The aim of this study is therefore to demonstrate the effectiveness of the association of primary closed rhinoplasty together with indirect subnasal lip-lifting technique. Read More

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Evaluation of Dual Versus Triple Therapy by Landmark Analysis in the RE-DUAL PCI Trial.

JACC Cardiovasc Interv 2021 Apr;14(7):768-780

Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: The aim of this study was to explore the early versus late benefits and risks of dabigatran dual therapy versus warfarin triple therapy in the RE-DUAL PCI (Randomized Evaluation of Dual Antithrombotic Therapy With Dabigatran Versus Triple Therapy With Warfarin in Patients With Nonvalvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention) trial.

Background: Patients with atrial fibrillation who undergo percutaneous coronary intervention are at increased risk for both bleeding and thrombotic events.

Methods: A total of 2,725 patients with atrial fibrillation underwent percutaneous coronary intervention and were randomized to receive dabigatran 110 mg, or dabigatran 150 mg plus a P2Y inhibitor (and no aspirin), or warfarin plus a P2Y inhibitor plus aspirin. Read More

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Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia.

Cells 2021 Mar 26;10(4). Epub 2021 Mar 26.

Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin synthesis, resulting in excess toxic free heme in erythroid progenitors, early differentiation arrest, and pure red cell aplasia. In this study, DBA induced pluripotent stem cell (iPSC) lines were generated from blood mononuclear cells of DBA patients with inactivating mutations in RPS19 and subjected to hematopoietic differentiation to model disease phenotypes. Read More

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Comparing Ligninolytic Capabilities of Bacterial and Fungal Dye-Decolorizing Peroxidases and Class-II Peroxidase-Catalases.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Centro de Investigaciones Biológicas "Margarita Salas" (CIB), CSIC, Ramiro de Maeztu 9, E-28040 Madrid, Spain.

We aim to clarify the ligninolytic capabilities of dye-decolorizing peroxidases (DyPs) from bacteria and fungi, compared to fungal lignin peroxidase (LiP) and versatile peroxidase (VP). With this purpose, DyPs from sp., , and , VP from , and LiP from were produced, and their kinetic constants and reduction potentials determined. Read More

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A randomized prospective multicenter trial for stroke prevention by prophylactic surgical closure of the left atrial appendage in patients undergoing bioprosthetic aortic valve surgery--LAA-CLOSURE trial protocol.

Am Heart J 2021 Jul 30;237:127-134. Epub 2021 Mar 30.

St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.

Patients undergoing surgical aortic valve replacement (SAVR) are at high risk for atrial fibrillation (AF) and stroke after surgery. There is an unmet clinical need to improve stroke prevention in this patient population. The LAA-CLOSURE trial aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patients undergoing bioprosthetic SAVR. Read More

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Management of excessive gingival display using botulinum toxin type A: a descriptive study.

Toxicon 2021 Jun 29;196:56-62. Epub 2021 Mar 29.

Department of Oral and Maxillofacial Surgery, Federal University of Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2492, Porto Alegre, RS, Brazil.

Botulinum toxin is a protease used by the bacterium Clostridium botulinum that causes chemical denervation of skeletal muscles, producing a temporary weakening of muscle activity. Despite having a transitory effect, the application of botulinum toxin has been identified as an alternative for correcting an excessive gingival display (EGD). However, studies evaluating the maintenance of long-term results of botulinum toxin remain scarce. Read More

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