1,842 results match your criteria Lip Reduction

Quercetin Reduces the Development of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Cleft Palate in Mice by Suppressing CYP1A1 via the Aryl Hydrocarbon Receptor.

Nutrients 2022 Jun 13;14(12). Epub 2022 Jun 13.

Department of Orthodontics, Tokyo Dental College, 2-9-18, Kandamisaki-Cho, Chiyoda-Ku, Tokyo 101-0061, Japan.

Quercetin is a flavonoid with a wide range of pharmacological activities, including anticancer, antioxidant, and anti-inflammatory effects. Since it is a nutrient that can be consumed with a regular diet, quercetin has recently garnered interest. Quercetin acts as a phytochemical ligand for the aryl hydrocarbon receptor (AhR). Read More

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Lip Lift Techniques in Smile Design.

Dent Clin North Am 2022 Jul 31;66(3):443-457. Epub 2022 May 31.

Private Practice.

The lips are the main aesthetic component of the facial lower third and simultaneously a substantial element for an ideally perceived smile. One of the most accepted and common procedures that is widely used to enhance the shape and contours of the upper lip is the lip lift. With a careful treatment plan and a professional surgery, a lip lift can reliably be used for the reduction of the philtrum height, enlargement of the upper vermilion, improvement of the dental show, restoration of facial aesthetic proportions, and creation of an enchanting smile. Read More

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A Prospective Randomized Study to Assess the Quality of Life in Post-Operative Recovery Phase in Patients Undergoing Surgery for Isolated Vertically Undisplaced Mandibular Parasymphysis Fracture Using Twin Mix Solution.

J Maxillofac Oral Surg 2022 Jun 31;21(2):413-419. Epub 2020 Oct 31.

Department of Conservative Dentistry and Endodontics, People's College of Dental Sciences and Research Center, People's University, Bhanpur, Bhopal, Madhya Pradesh 462037 India.

Purpose: Trauma is a major cause for facial fractures commonly encountered by maxillofacial surgeons. Mandible is commonly involved in facial trauma resulting in an isolated fracture or associated with other facial bones due to its prominent location in the facial skeleton. This study was undertaken to investigate the quality of life (QoL) post-operatively in patients diagnosed with undisplaced parasymphysis fracture who underwent open reduction and internal fixation (ORIF) under local anesthesia (LA) using the twin mix (TM) solution. Read More

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Comparative study of the effect of BlueM active oxygen gel and coe-pack dressing on postoperative surgical depigmentation healing.

Saudi Dent J 2022 May 21;34(4):328-334. Epub 2022 Apr 21.

Department of Periodontology, Faculty of Dentistry, Damascus University, Mazzeh, Damascus, Syria.

Introduction: Black colored gingiva is an esthetic concern, especially when accompanied by a high lip line or gummy smile.Surgical depigmentation with a scalpel is still considered the golden standard in gingival pigmentation management although it causes an area of open wound, which needs a special management with dressing.This study aimed to comparatively evaluate the effectiveness of reactive oxygen gel species (BlueM gel) and the traditional Coe-Pack dressing on gingival healing and pain after surgical depigmentation. Read More

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Skeletal, Dental and Soft Tissue Cephalometric Changes after Orthodontic Treatment of Dental Class II Malocclusion with Maxillary First Molar or First Premolar Extractions.

J Clin Med 2022 Jun 2;11(11). Epub 2022 Jun 2.

Department of Biomedical, Surgical and Dental Sciences, Section of Orthodontics, University of Milan, 20122 Milan, Italy.

The aim of the present retrospective study was evaluating skeletal, dental and soft tissue changes of two groups of Class II patients orthodontically treated with extractions of upper first premolars (U4 group) and upper first molars (U6 group). In total, 21 patient records (9M and 12F; mean age 12.5 ± 1. Read More

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Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review.

JAMA Cardiol 2022 Jun 1. Epub 2022 Jun 1.

Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, United Kingdom.

Importance: Dose-reduced regimens of direct oral anticoagulants (DOACs) may be used for 2 main purposes: dose-adjusted treatment intended as full-intensity anticoagulation (eg, for stroke prevention in atrial fibrillation [AF] in patients requiring dose reduction) or low-intensity treatment (eg, extended-duration treatment of venous thromboembolism [VTE]). We reviewed randomized clinical trials (RCTs) to understand the scenarios in which dose-adjusted or low-intensity DOACs were tested and reviewed the labeled indications by regulatory authorities, using data from large registries to assess whether the use of dose-reduced DOACs in routine practice aligned with the findings of RCTs.

Observations: Among 4191 screened publications, 35 RCTs that used dose-adjusted DOACs were identified for dabigatran, apixaban, rivaroxaban, and edoxaban. Read More

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Reviewing ACGME Plastic Surgery Fellowship Case Logs: Is Surgical Experience Increasing?

J Surg Res 2022 May 17;278:70-78. Epub 2022 May 17.

Department of Surgery, University of Texas Medical Branch, Galveston, Texas. Electronic address:

Introduction: Over the last decade, there has been a 32% decrease in independent plastic surgery fellowships. The growing prevalence of 6-year integrated plastic surgery residencies, duty hour restrictions, and new subspecialty training fellowships for general surgeons have changed the training experience of plastic surgery fellows.

Methods: A retrospective review of the Accreditation Council for Graduate Medical Education (ACGME) case logs for graduating fellows of independent plastic surgery fellowships in the United States was conducted from 2011 to 2019. Read More

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Impact of Integrated Care Management on Clinical Outcomes in Atrial Fibrillation Patients: A Report From the FANTASIIA Registry.

Front Cardiovasc Med 2022 2;9:856222. Epub 2022 May 2.

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, CIBERCV, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.

Background: An integrated and holistic approach is increasingly advocated in patients with atrial fibrillation (AF), based on the "Atrial fibrillation Better Care (ABC) pathway: A, Avoid stroke with anticoagulation; B, better symptom management; C, cardiovascular and comorbidity risk management." The aim of this study was to examine the prevalence of adherence to each component of the ABC pathway and to analyze its impact on long-term prognosis in the "real-world" cohort of AF patients from the FANTASIIA registry.

Methods: This prospective study included consecutive AF outpatients anticoagulated with direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) from June 2013 to October 2014. Read More

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Myomodulation using hyaluronic acid fillers as an efficient and innovative treatment for gummy smile: A case report.

J Oral Biol Craniofac Res 2022 May-Jun;12(3):376-380. Epub 2022 May 4.

Dental Research Division, School of Dentistry, Ibirapuera University, São Paulo, Brazil.

Myomodulation (MyoMo) using hyaluronic acid (HA) fillers can be considered as a novel aesthetic treatment for gummy smile (GS). However, literature is still lacking information about this procedure. For this reason, the aim of the present case report was to describe a technique for MyoMo with HA as an efficient alternative for the management of GS. Read More

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Thionitrite (SNO ) and Perthionitrite (SSNO ) are Simple Synthons for Nitrosylated Iron Sulfur Clusters.

Angew Chem Int Ed Engl 2022 May 17:e202204570. Epub 2022 May 17.

Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and Institute of Molecular Biology, University of Oregon, Eugene, OR 97403-1253, USA.

S/N crosstalk species derived from the interconnected reactivity of H S and NO facilitate the transport of reactive sulfur and nitrogen species in signaling, transport, and regulatory processes. We report here that simple Fe ions, such as those that are bioavailable in the labile iron pool (LIP), react with thionitrite (SNO ) and perthionitrite (SSNO ) to yield the dinitrosyl iron complex [Fe(NO) (S )] . In the reaction of FeCl with SNO we were able to isolate the unstable intermediate hydrosulfido mononitrosyl iron complex [FeCl (NO)(SH)] , which was characterized by X-ray crystallography. Read More

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Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair.

Front Immunol 2022 27;13:871200. Epub 2022 Apr 27.

Center for Clinical and Translational Research, Forsyth Institute, Cambridge, MA, United States.

Objective: Residual scarring after cleft lip repair surgery remains a challenge for both surgeons and patients and novel therapeutics are critically needed. The objective of this preclinical experimental study was to evaluate the impact of the methyl-ester of pro-resolving lipid mediator lipoxin A (LXA-ME) on scarring in a novel rabbit model of cleft lip repair.

Methods: A defect of the lip was surgically created and repaired in eight six-week old New Zealand white rabbits to simulate human cleft lip scars. Read More

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Evaluation of parameters related with upper lip aesthetics and dynamic smile following Le Fort I osteotomy.

J Stomatol Oral Maxillofac Surg 2022 May 11. Epub 2022 May 11.

Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Istanbul Medipol University, Istanbul, Turkey.

Objective: The present study aimed to investigate how upper lip aesthetic and dynamic smile parameters are changed following a Le Fort I osteotomy.

Methods: Twenty-seven patients who underwent Le Fort I osteotomy with or without mandibular osteotomy were included in this retrospective study. Upper lip aesthetic parameters which were Cupid's bow angle, lip angle, lip length, lip width, philtrum width and lip corners were evaluated on pre and postoperative rest photos using Image J software. Read More

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Relationship between Serum 25-Hydroxyvitamin D Level and Risk of Recurrent Stroke.

Nutrients 2022 May 2;14(9). Epub 2022 May 2.

Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool L69 3BX, UK.

Evidence for the association between vitamin D and risk of recurrent stroke remains sparse and limited. We aimed to assess the relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history, and to identify the optimal 25(OH)D level in relation to lowest recurrent stroke risk. Data from the nationwide prospective United Kingdom Biobank were used for analyses. Read More

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LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.

Autophagy 2022 May 19:1-14. Epub 2022 May 19.

Inovação em Saúde, Universidade do PortoInstituto de Investigação e , Porto, Portugal.

Within the thymus, thymic epithelial cells (TECs) provide dedicated thymic stroma microenvironments for T cell development. Because TEC functionality is sensitive to aging and cytoablative therapies, unraveling the molecular elements that coordinate their thymopoietic role has fundamental and clinical implications. Particularly, the selection of CD4 T cells depends on interactions between TCRs expressed on T cell precursors and self-peptides:MHC II complexes presented by cortical TECs (cTECs). Read More

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Marsupialization of Dentigerous Cysts Followed by Enucleation and Extraction of Deeply Impacted Third Molars: A Report of Two Cases.

Cureus 2022 Apr 2;14(4):e23772. Epub 2022 Apr 2.

Oral and Maxillofacial Surgery and Diagnostic Sciences, Riyadh Elm University, Riyadh, SAU.

A dentigerous cyst (DC) is a developmental odontogenic cyst that involves the crown or a portion of the crown of an unerupted or impacted tooth. Mandibular third molars are the most commonly implicated teeth in this type of cyst. DC can be asymptomatic and detected by an ordinary radiographic examination. Read More

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Case Report: Psychoacoustic Analysis of a Clarinet Performance With a Custom-Made Soft Lip Shield Worn to Prevent Mucosal Erosion of Lower Lip.

Front Psychol 2022 21;13:852866. Epub 2022 Apr 21.

Department of Maxillofacial Prosthetics, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: Wind instrument players sometimes suffer from erosion of the mucous membrane of the lip. This is caused by the action and pressure of the mouthpiece of the wind instrument against teeth. To address this problem, a lip shield is fitted over the dental arch to prevent direct contact between the lips and teeth. Read More

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Primary care in early cleft lip and palate rehabilitation: A dental perspective.

J Family Med Prim Care 2022 Mar 10;11(3):1212-1215. Epub 2022 Mar 10.

Department of Prosthodontics and Crown & Bridge, Goa Dental College and Hospital, Bambolim, Goa, India.

Oro-facial clefts are among the most commonly occurring congenital defects. Surgical interventions are commonly carried out to treat these deformities. Some inadequacies however, like scarring of the nasolabial complex and multiple interventions to achieve desired results still persist. Read More

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A Standardized Technique for Gummy Smile Treatment Using Repeated Botulinum Toxins: A 1-year Follow-up Study.

Noury Adel

Plast Reconstr Surg Glob Open 2022 Apr 25;10(4):e4281. Epub 2022 Apr 25.

Oral and Maxillofacial Surgery Specialist, Cairo, Egypt.

The present study was performed to evaluate the effect of repeated botulinum toxin injections and their long-term effects, using a customized injection point and dosage technique in the treatment of excessive gingival display. Twenty women who had gummy smile due to hypermobility of the upper lip or gingival display, ranging from 4 to 6 mm' were included in the study. All patients were injected with Botox injections at different injection points according to the type of smile. Read More

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Investigating the displacement of radio-active sources during gold-198 grain brachytherapy for hospitalized oral cancer patients.

J Contemp Brachytherapy 2022 Apr 23;14(2):115-122. Epub 2022 Mar 23.

Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

Purpose: This study aimed to investigate status of displacement of gold-198 (Au) grains in patients with oral cancers as well as factors and countermeasures for the displacement of Au grains.

Material And Methods: The present study included 34 patients with oral cancers, who were exclusively treated with Au grain brachytherapy between 2013 and 2019. Timing and duration of the Au grain displacement from the oral cavity and reduction in radiation dose were estimated. Read More

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Impact of early ablation of atrial fibrillation on long-term outcomes: results from phase II/III of the GLORIA-AF registry.

Clin Res Cardiol 2022 Apr 29. Epub 2022 Apr 29.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.

Background: First-line ablation for atrial fibrillation (AF) reduces the risk of recurrent atrial arrhythmias compared to medical therapy. However, the prognostic benefit of early AF ablation remains undetermined. Herein, we aimed to evaluate the effects of early AF ablation compared to medical therapy. Read More

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Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis.

Int Immunopharmacol 2022 Aug 25;109:108770. Epub 2022 Apr 25.

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Key Site of National Clinical Research Center for Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.. Electronic address:

Background And Purpose: Ferroptosis is closely associated with respiratory diseases; however, the relationship between ferroptosis and neutrophilic asthma remains unknown. This study investigated whether Liproxstatin-1 (Lip-1) affects the progression of neutrophilic asthma by inhibiting ferroptosis and inflammatory response, while dissecting the underlying molecular mechanisms.

Methods: The bronchial epithelial cells (16HBE and BEAS-2B) were administered with lipopolysaccharide (LPS) and interleukin-13 (IL-13) to generate a cell injury model. Read More

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Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles.

Pharmaceutics 2022 Apr 6;14(4). Epub 2022 Apr 6.

Division of Biophysics, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8010 Graz, Austria.

This study aimed to design a hybrid oral liposomal delivery system for selenium nanoparticles (Lip-SeNPs) to improve the bioavailability of selenium. Thiolated chitosan, a multifunctional polymer with mucoadhesive properties, was used for surface functionalization of Lip-SeNPs. Selenium nanoparticle (SeNP)-loaded liposomes were manufactured by a single step microfluidics-assisted chemical reduction and assembling process. Read More

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Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice.

Cell Death Discov 2022 Apr 21;8(1):217. Epub 2022 Apr 21.

Department of Otolaryngology-Head & Neck Surgery, Case Western Reserve University, Cleveland, OH, USA.

Otitis media (OM) is a common disease that can cause hearing loss in children. Currently, the main clinical treatment for OM is antibiotics, but the overuse of antibiotics might lead to bacterial resistance, which is a worldwide public health challenge. Studying the pathogenesis of OM will help us develop new effective treatments. Read More

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Atypical case of arteriovenous malformation invading into a pedicled medial arm flap.

BMJ Case Rep 2022 Apr 20;15(4). Epub 2022 Apr 20.

Plastic, Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India

A 54-year-old woman who had previously undergone total excision of an arteriovenous malformation (AVM) of lower lip and chin along with pedicled medial arm flap reconstruction, presented with recurrence of swelling in the same region. The patient reported progressive difficulty in feeding, talking and constant aching pain besides aesthetic concerns. On evaluation, recurrence of AVM with invasion into the flap substance was identified. Read More

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Estimating excess visual loss from neovascular age-related macular degeneration in the UK during the COVID-19 pandemic: a retrospective clinical audit and simulation model.

BMJ Open 2022 04 15;12(4):e057269. Epub 2022 Apr 15.

Moorfields Eye Hospital, Moorfields Eye Hospital NHS Foundation Trust, London, UK

Objectives: To report the reduction in new neovascular age-related macular degeneration (nAMD) referrals during the COVID-19 pandemic and estimate the impact of delayed treatment on visual outcomes at 1 year.

Design: Retrospective clinical audit and simulation model.

Setting: Multiple UK National Health Service (NHS) ophthalmology centres. Read More

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Factors associated with a reduced food intake after third molar extraction among adults: a cross-sectional study.

BMC Oral Health 2022 04 11;22(1):120. Epub 2022 Apr 11.

Department of Oral and Maxillofacial Surgery, Nagoya Ekisaikai Hospital, Nagoya, 454-8502, Japan.

Background: Functional impairment after third molar extraction may decrease the food intake. Elucidation of associated factors will contribute to a more appropriate postoperative nutritional management, and was the aim of the present study.

Methods: Adults aged < 60 years who were admitted for an extraction of one or more mandibular third molars were included. Read More

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Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis.

Birth Defects Res 2022 06 31;114(10):467-477. Epub 2022 Mar 31.

Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA.

Background: We conducted a meta-analysis of observational epidemiological studies to evaluate the association between periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts (NSOFCs).

Methods: We carried out a systematic literature search of Embase, PubMed, Web of Science, Google Scholar, and OpenGrey from inception to June 30, 2021. Two reviewers independently evaluated the studies that met the inclusion criteria and filled out an abstraction form for each study. Read More

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Density of Health Workforce Correlates to Disease Outcomes: Evidence From Global Data in Otolaryngology.

OTO Open 2022 Jan-Mar;6(1):2473974X221089840. Epub 2022 Mar 24.

Brighton and Sussex Medical School, Brighton, UK.

Objective: To better understand the impact of the otolaryngology-specific workforce on the burden of related diseases.

Study Design: Retrospective analysis of existing workforce density data as compared with the incidence, mortality, and morbidity data for 4 otolaryngologic diseases.

Setting: An overall 138 countries with known otolaryngology-head and neck surgery workforce and epidemiologic data. Read More

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Effective bioremediation of pulp and paper mill wastewater using Bacillus cereus as a possible kraft lignin-degrading bacterium.

Bioresour Technol 2022 May 26;352:127076. Epub 2022 Mar 26.

Environmental Microbiology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India. Electronic address:

The effective degradation of KL from paper mill effluent is an important for environmental safety. This research is primarily concerned with the identification of KL-degrading Bacillus cereus from activated sludge and their possible use for the degradation of Kraft lignin (KL). This strain was involved in the production of lignin peroxidase-LiP (3. Read More

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Clinical efficacy of lip repositioning technique and its modifications for the treatment of gummy smile: systematic review and meta-analysis.

Clin Oral Investig 2022 Jun 28;26(6):4243-4261. Epub 2022 Mar 28.

Department of Periodontology, School of Dentistry, Universidad Cientifica del Sur, Panamericana Sur Km 19, Villa, Lima, Peru.

Objective: To systematically review the literature regarding the clinical efficacy of reducing excessive gingival display (EGD) using the surgical lip repositioning technique (LRT) and its modifications. The question to address was: "What is the clinical efficacy of the surgical LRT and its modifications in patients with EGD?"

Material And Methods: Four databases (MEDLINE-PubMed, Scopus, EMBASE, and CENTRAL) were searched up to December 2021 (PROSPERO-CRD42020205987). Randomized, non-randomized controlled and prospective case series with a minimum of 6-month follow-up were eligible for inclusion. Read More

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