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    519 results match your criteria Linear IgA Dermatosis

    1 OF 11

    [A particular type of cicatricial Pemphigoid with unique IgA deposit].
    Pan Afr Med J 2017 13;26:136. Epub 2017 Mar 13.
    Université de Sousse, Tunisie.
    Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Read More

    Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.
    J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

    Linear immunoglobulin A dermatosis: A case report.
    Medwave 2017 Apr 4;17(3):e6901. Epub 2017 Apr 4.
    Facultad de Medicina, Universidad de Chile, Santiago, Chile.
    We present the case of a sixty five year old woman with two months history of pruritus and hyperpigmented annular lesions on the trunk, buttocks and upper extremities. In addition, she presents vesicles with healthy skin on the basis, in the flexor aspect of wrists. No evidence of mucosal involvement. Read More

    Human Orf complicated by Epidermolysis Bullosa Acquisita.
    Br J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Dermatology Department, Saint-Louis Hospital, Paris, France.
    Orf is a DNA parapoxvirus transmitted to humans by contact with infected goats and sheep. Many complications have been reported after Orf infection including erythema multiforme. A few cases of auto-immune bullous dermatosis complicating Orf disease have been reported to date, usually characterized by tense blisters eruptions with or without mucosal involvement, linear deposition of C3, IgG and/or IgA along the basement membrane and negativity of indirect immunofluorescence analysis and ELISA assays (performed in 4 of 11 reported cases) against target antigens of bullous pemphigoid, mucous membrane pemphigoid or epidermolysis bullosa acquisita, except one case of mucosal pemphigoid with antilaminin-332 antibodies. Read More

    Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):35-38
    Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
    Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. Read More

    Linear IgA and IgG bullous dermatosis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):32-34
    Hospital Federal de Bonsucesso (HFB) -Rio de Janeiro (RJ), Brazil.
    Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. Read More

    Linear Immunoglobulin A dermatosis mimicking Toxic Epidermal Necrolysis: a case report of etanercept treatment.
    Br J Dermatol 2017 Feb 21. Epub 2017 Feb 21.
    Departments of Dermatology, Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense.
    A 65-year-old pluripathological woman attended our hospital with a cutaneous eruption of sudden appearance after vancomycin treatment. She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions, with mucosal lesions and positive Nikolsky sign. Under the initial clinical suspicion of Toxic Epidermal Necrolysis (TEN), and considering recent literature of its successful use in these cases, she was treated with a single dose of anti-Tumor Necrosis Factor (anti-TNF) agent etanercept. Read More

    A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis.
    Case Rep Dermatol Med 2017 10;2017:7318305. Epub 2017 Jan 10.
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
    Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. Read More

    Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap.
    Clin Exp Dermatol 2017 Apr 13;42(3):299-302. Epub 2017 Jan 13.
    Department of Dermatology, Alfred Hospital, Melbourne, VIC, Australia.
    Linear IgA bullous dermatosis (LABD) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation of this disease is heterogeneous. LABD clinically presenting as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is an infrequent, yet well-described phenomenon. Read More

    Bullous Dermatosis in an End-Stage Renal Disease Patient: A Case Report and Literature Review.
    Case Rep Nephrol 2016 24;2016:6713807. Epub 2016 Nov 24.
    Division of Nephrology and Hypertension, Department of Internal Medicine, Wayne State University Detroit Medical Center, Detroit, MI, USA.
    Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic possibilities, and subsequent rise of a puzzling diagnostic challenge. We describe an ESRD patient who presented with blistering, nonhealing ulcerative lesions with a diagnostic skin biopsy revealing a mixed pattern of linear IgA bullous dermatosis and dermatitis herpetiformis. Read More

    Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case series of 72 adults.
    Br J Dermatol 2016 Dec 20. Epub 2016 Dec 20.
    Referral Center for Autoimmune Blistering Diseases, Île-de-France, France.
    Background: Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune bullous disease (AIBD), for which the long-term evolution is poorly described.

    Objectives: To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD.

    Methods: This retrospective study, conducted in our AIBD referral centre, included adults, diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence. Read More

    A clinical and serological study of linear IgA bullous dermatosis without linear immunoglobulin deposition other than IgA at the basement membrane zone using direct immunofluorescence.
    Br J Dermatol 2016 Dec 11. Epub 2016 Dec 11.
    Department of Dermatology, Kurume University School of Medicine, Kurume 830-0011, Japan.
    Background: Linear IgA bullous dermatosis (LABD) is a heterogeneous disease. Different diagnostic criteria have been used in different reports.

    Objectives: To reappraise the characteristic features of LABD with only IgA deposition at the basement membrane zone (BMZ) with direct immunofluorescence (DIF). Read More

    Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans.
    J Dermatol 2017 Apr 3;44(4):461-464. Epub 2016 Dec 3.
    Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Bronchiolitis obliterans is a small-airway obstructive lung disease for which immunologically mediated pathogenesis is supposed. Frequent association of bronchiolitis obliterans with paraneoplastic pemphigus is well known, but its association with other autoimmune bullous diseases has not been reported except for a case of anti-laminin-332-type mucous membrane pemphigoid in a patient with chronic graft-versus-host disease. We report a case of non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans in a patient without transplantation. Read More

    Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment.
    Am J Clin Dermatol 2017 Feb;18(1):105-126
    Department of Dermatology, University of Illinois College of Medicine, UIC-Derm, MC624, 808 S. Wood Street, R380, Chicago, IL, 60612, USA.
    Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Read More

    [Topical corticosteroids as a therapeutic alternative in linear immunoglobulin A bullous dermatosis in childhood: case report].
    Arch Argent Pediatr 2016 Dec;114(6):e440-e443
    Servicio de Dermatología, Hospital García Orcoyen, Estella, España.
    Linear immunoglobulin A dermatosis of childhood is a rare autoimmune disorder. Its etiology remains unknown, although it has been linked to drugs, infections, immunological diseases and lymphoproliferative processes. We report the case of a 6 year old girl who consulted for perioral bullous lesions without other symptoms. Read More

    Development of bullous pemphigoid in a patient with psoriasis and metabolic syndrome.
    Cutis 2016 Sep;98(3):E19-E23
    Department of Dermatology and Immunodermatology, Medical University of Warsaw, Poland.
    Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that most commonly affects adults older than 60 years, whereas psoriasis vulgaris (PV) is a chronic immune-mediated disease that affects both children and adults. Bullous pemphigoid and PV may coexist with each other as well as with various other internal disorders, which may lead to early death. We report the case of a 35-year-old man with a 15-year history of PV and obesity who developed tense blisters with annular arrangement and normal-appearing perilesional skin localized mainly on the trunk, arms, and legs resembling linear IgA bullous dermatosis. Read More

    Vancomycin-induced linear IgA bullous dermatosis: associations.
    Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
    Coimbra University Hospital, Coimbra.
    Unlabelled: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases. Read More

    Specificity of granular IgM deposition in folliculosebaceous units and sweat gland apparatus in direct immunofluorescence (DIF) of lupus erythematosus.
    J Am Acad Dermatol 2016 Aug 28;75(2):404-9. Epub 2016 May 28.
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:
    Background: Diagnosis of lupus erythematosus (LE) in direct immunofluorescence testing is based on the finding of positive immunofluorescence at the dermoepidermal junction (DEJ).

    Objectives: We sought to evaluate the sensitivity of IgM deposition at the DEJ and adnexal structures in the diagnosis of lupus erythematosus.

    Methods: We conducted a retrospective study of 100 previously diagnosed cases of lupus erythematosus and 158 cases of other immune-mediated dermatosis. Read More

    Immune-mediated reactions to vancomycin: A systematic case review and analysis.
    Ann Allergy Asthma Immunol 2016 Jun 4;116(6):544-53. Epub 2016 May 4.
    Harvard Medical School, Boston, Massachusetts; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts; Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts.
    Background: Vancomycin is a broad-spectrum antibiotic whose use may be limited by adverse drug reactions (ADRs). Although vancomycin toxic effects are known, there are limited data on vancomycin hypersensitivity reactions (HSRs).

    Objective: To understand the most commonly reported vancomycin HSRs through systematic case review. Read More

    Pemphigus vulgaris-associated interstitial lung disease.
    Dermatol Ther 2016 Jul 11;29(4):228-32. Epub 2016 Mar 11.
    Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.
    Autoimmune bullous diseases (AIBDs)-associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV-associated ILD has rarely been reported in English literature. Read More

    A subepidermal blistering disorder.
    S Afr Med J 2016 Feb 22;106(3):263. Epub 2016 Feb 22.
    Department of Internal Medicine, Addington Hospital, Durban, South Africa.
    A young woman presented with generalised tense blisters. There had been no previous drug exposure and she had no clinical signs of autoimmune disease or evidence of sepsis. Given the abrupt onset and clinical scenario, a skin punch biopsy was performed and a tentative diagnosis of linear IgA bullous dermatosis (LABD) was made. Read More

    Bullous diseases: Kids are not just little people.
    Clin Dermatol 2015 Nov-Dec;33(6):644-56. Epub 2015 Sep 14.
    Departments of Dermatology & Pediatrics, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, 12th Floor, New York, NY, 10032, USA. Electronic address:
    Bullous diseases may be rare; however, this does not preclude the clinician from being familiar with their manifestations and treatment. After ruling out infection, genetically inherited blistering diseases are more likely to be the cause of blistering or erosions in the neonatal period, whereas immunobullous diseases are more common in adults. Published literature on immunobullous disorders reflects information gleaned from case reports and open-label case series; prospective studies and evidence-based treatments are limited. Read More

    Linear IgA Bullous Dermatosis: A Rare Clinicopathologic Entity with an Unusual Presentation.
    J Clin Aesthet Dermatol 2015 Oct;8(10):43-6
    University of Nevada School of Medicine, Reno and Las Vegas, Nevada; Associated Pathologists, Chartered, Las Vegas, Nevada.
    Linear immunoglobulin A bullous dermatosis is a rare autoimmune mucocutaneous disorder caused by immunoglobulin A autoantibodies produced against several different antigens in the basement membrane zone. Clinically, it is characterized by tense vesicles or bullae, which on histopathological exam demonstrate subepidermal blister with a predominantly neutrophilic infiltrate. A smooth, linear pattern of immunoglobulin A deposition in the basement membrane zone on direct immunofluorescence is considered the gold standard for establishing a diagnosis. Read More

    Kaposi varicelliform eruption in patients with autoimmune bullous dermatoses.
    Int J Dermatol 2016 Mar 24;55(3):e136-40. Epub 2015 Oct 24.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Background: Viral superinfection of skin affected by preceding dermatosis has been studied extensively in eczema and reported anecdotally in pemphigus. Little is known about its involvement and complications in patients with other immunobullous diseases.

    Methods: To investigate clinical features and complications of viral superinfection in patients with immunobullous diseases, we performed a retrospective chart review. Read More

    Generalized linear IgA dermatosis with palmar involvement.
    Dermatol Online J 2015 Sep 17;21(9). Epub 2015 Sep 17.
    University of Louisville School of Medicine.
    Linear IgA bullous dermatosis (LABD) is a sub-epidermal blistering disorder characterized by deposition of IgA along the basement membrane zone (BMZ) as detected by immunofluorescence microscopy. The diagnosis is made by clinicopathologic correlation with immunofluorescence confirmation. Differentiation from other bullous dermatoses is important because therapeutic measures differ. Read More

    Retrospective Study on Autoimmune Blistering Disease in Paediatric Patients.
    Pediatr Dermatol 2015 Nov-Dec;32(6):845-52. Epub 2015 Sep 22.
    Division of Dermatology, National University Hospital, Singapore, Singapore.
    Background: Autoimmune blistering diseases (AIBDs) are rare in children and their prevalence in Singapore is unclear. We aimed to investigate the clinical and immunopathologic characteristics of children diagnosed with AIBDs in Singapore.

    Materials And Methods: The clinical and histology databases at the National Skin Centre in Singapore were searched to identify patients younger than 18 years old diagnosed with an AIBD from January 1, 1998, through December 31, 2012. Read More

    Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis.
    Case Rep Dermatol 2015 May-Aug;7(2):183-6. Epub 2015 Jul 25.
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is an autoimmune mucocutaneous disease characterized by subepidermal blistering induced by IgA autoantibodies against several autoantigens in the basal membranous zone of the skin and mucosal tissue. Although diaminodiphenyl sulfone (DDS), also known as dapsone, is generally recognized as the first-line therapy for LABD, DDS can induce several severe side effects. We present a Japanese case of LABD with DDS-induced hemolytic anemia and alopecia. Read More

    Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone.
    J Dermatol 2016 Feb 29;43(2):194-6. Epub 2015 Jul 29.
    Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.
    We report a case involving a 62-year-old woman with in vivo-bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo-bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. Read More

    Linear IgA dermatosis adult variant with oral manifestation: A rare case report.
    J Oral Maxillofac Pathol 2015 Jan-Apr;19(1):83-7
    Department of Oral Pathology and Microbiology, Sree Mookambika Institute of Dental Sciences, Padanilam, Kulasekharam, Tamil Nadu, India.
    Linear immunoglobulin A (IgA) dermatosis (LAD) is a rare autoimmune disorder that presents as a vesiculo-bullous lesion with cutaneous manifestations, but rare oral mucosal involvement. Here we discuss a case of a vesiculobullous lesion with severe oral and ocular mucosal involvement mimicking pemphigoid with histopathological evidence of subepithelial blisters. Direct immunofluorescence (DIF) confirmed the lesion as LAD of adult variant, although with atypical clinical features. Read More

    Linear IgA Bullous Dermatosis Secondary to Infliximab Therapy in a Patient with Ulcerative Colitis.
    Dermatology 2015 16;231(2):112-5. Epub 2015 Jun 16.
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
    Linear IgA bullous disease (LABD) is a rare vesiculobullous autoimmune skin disorder whose etiology and pathogenesis are not completely understood. Its occurrence has been related to malignancies, inflammatory diseases and several drugs. This report describes a 49-year-old Caucasian male with a 14-year history of ulcerative colitis who received infliximab to treat the refractory course of his bowel disease. Read More

    Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy.
    Ann Dermatol 2015 Jun 29;27(3):315-8. Epub 2015 May 29.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g. Read More

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