581 results match your criteria Linear IgA Dermatosis


Bullous dermatosis suspected in an 8-month-old child in Guinea-Bissau.

Oxf Med Case Reports 2019 Apr 15;2019(4):omz004. Epub 2019 Apr 15.

Buenos Aires, Argentina.

An 8-month-old child was admitted to a paediatric intensive care unit in Guinea-Bissau with severe blistering dermatosis. He was treated with broad spectrum antibiotics and dressings, without improvement. After 2 weeks, linear IgA bullous dermatosis was suspected. Read More

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http://dx.doi.org/10.1093/omcr/omz004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464016PMC

Cephalosporin-induced linear IgA dermatosis in a child: case report and literature review.

Dermatol Ther 2019 Apr 12:e12927. Epub 2019 Apr 12.

Department of Dermatology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Linear IgA dermatosis (LAD) is a rare, subepidermal blistering disease with mucocutaneous involvement. It may be idiopathic or drug induced. We describe a 4-year-old girl who presented with a vesiculobullous eruption after she had been treated with cefixime for urinary tract infection. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12927
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http://dx.doi.org/10.1111/dth.12927DOI Listing
April 2019
1 Read

Direct Immunofluorescence Studies in Lichen Planus.

Turk Patoloji Derg 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Bharati Vidyapeeth (deemed to be university) Medical College and Hospital, SANGLI, INDIA.

Objective: Lichen planus is a common, usually intensely pruritic, symmetrical, papulosquamous dermatosis. Direct immunofluorescence studies in patients with lichen planus shows deposition of multiple immunoglobulins and fibrin at the dermoepidermal junction and in the colloid bodies.

Material And Method: Histopathological features were analysed in 100 cases of lichen planus which were sent for routine histology. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01455DOI Listing

Erythrodermic linear IgA/IgG bullous dermatosis.

Eur J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Abeno-ku, Osaka 545-8585, Japan.

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http://dx.doi.org/10.1684/ejd.2019.3503DOI Listing

A Case of Recalcitrant Linear IgA Bullous Dermatosis: Successfully Treated with Rituximab.

Dermatol Ther 2019 Apr 9:e12911. Epub 2019 Apr 9.

Department of Dermatology, Faculty of Medicine, Selcuk University, Konya, Turkey.

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http://dx.doi.org/10.1111/dth.12911DOI Listing

[Linear IgA bullous dermatosis].

Hautarzt 2019 Apr;70(4):254-259

Klinik für Dermatologie, Venerologie und Dermatoonkologie, Fakultät für Medizin, Semmelweis Universität, Budapest, Ungarn.

Linear IgA bullous dermatosis is a rare autoimmune blistering disease that occurs in both children and adults. Strings of pearls, crowns of jewels, rosettes and urticarial plaques can occur on the whole integument with emphasis on the face (particularly perioral area) and genitalia. Pruritus is common and may be severe. Read More

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http://dx.doi.org/10.1007/s00105-019-4377-9DOI Listing

Linear IgA bullous dermatosis protracted by vancomycin-loaded bone cement.

JAAD Case Rep 2019 Mar 22;5(3):234-236. Epub 2019 Feb 22.

Department of Dermatology, MetroHealth Medical System, Case Western University, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389549PMC

Drug-induced Linear IgA Bullous Dermatosis: a Case Report and Review of the Literature.

Acta Derm Venereol 2019 Feb 27. Epub 2019 Feb 27.

Department of Dermatology and Allergology, Technical University Munich, DE-80802 Munich, Germany.

Linear IgA bullous dermatosis (LABD) is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. Although most reported cases are idiopathic, there is a subset of patients with drug-induced LABD. Various drugs have been associated with the drug-induced form of the disease. Read More

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http://dx.doi.org/10.2340/00015555-3154DOI Listing
February 2019
1 Read

Linear IgA bullous dermatosis treated with rituximab.

JAAD Case Rep 2019 Feb 12;5(2):124-126. Epub 2019 Jan 12.

Dermatology Department, Institute for Research and Innovation in Biomedicine, Rouen University Hospital, University of Normandy, Rouen, France.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330365PMC
February 2019
2 Reads

Systemic Lupus Erythematosus with Linear IgA Bullous Dermatosis and Renal Vascular Lesions: An Extremely Rare Association.

Indian J Nephrol 2018 Nov-Dec;28(6):465-467

Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India.

We report a rare case of systemic lupus erythematosus presenting initially with cutaneous manifestations of linear IgA bullous dermatosis. Later the patient developed renal abnormalities due to thrombotic microangiopathy and lupus nephritis with inflammatory necrotizing vasculitis. Paucity of immune deposits was observed on Immunofluorescence. Read More

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http://dx.doi.org/10.4103/ijn.IJN_200_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309391PMC
January 2019
1 Read

Drug-induced linear immunoglobulin A bullous dermatosis: A French retrospective pharmacovigilance study of 69 cases.

Br J Clin Pharmacol 2019 Mar 4;85(3):570-579. Epub 2019 Jan 4.

EA 7379 EpiDermE, Université Paris Est Créteil Val de Marne UPEC, Créteil, France.

Aims: Linear immunoglobin A (IgA) bullous dermatosis is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs and highlighted suspected drugs.

Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Read More

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http://dx.doi.org/10.1111/bcp.13827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379232PMC
March 2019
8 Reads

Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.

Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001313DOI Listing
November 2018
3 Reads

["Decoratively figured blisters" on the whole integument in initially diagnosed ulcerative colitis].

Hautarzt 2019 Mar;70(3):210-214

Klinik- und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsmedizin Greifswald, Greifswald, Deutschland.

The rare case of a 61-year-old patient suffering from linear IgA dermatosis is presented. The patient was previously hospitalized with chronic inflammatory bowel disease. The correct diagnosis of the disease was based on clinical and histological findings. Read More

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http://dx.doi.org/10.1007/s00105-018-4314-3DOI Listing
March 2019
11 Reads

[Pediatric linear IgA/IgG dermatosis].

Hautarzt 2018 Oct;69(Suppl 1):28-30

Klinik für Dermatologie der Semmelweis Universität, Budapest, Ungarn.

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http://dx.doi.org/10.1007/s00105-018-4192-8DOI Listing
October 2018
2 Reads

Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

Naval Medical Center, San Diego, California.

Linear IgA bullous dermatosis is a rare bullous disease in children and adults that can be associated with autoimmune conditions, malignancies, infections, or medication exposure. The definitive diagnosis relies on the biopsy. A 58-year-old man presented to our clinic with a pruritic vesicular and bullous eruption. Read More

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July 2018
5 Reads

Linear IgA bullous dermatosis presenting as chronic prurigo: unveiling of the diagnosis by serrated pattern analysis.

Int J Dermatol 2018 11 19;57(11):e147-e149. Epub 2018 Sep 19.

Department of Dermatology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, India.

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http://dx.doi.org/10.1111/ijd.14253DOI Listing
November 2018
3 Reads

Non-infectious diffuse vesiculobullous rash in a pancreas and renal transplant recipient.

Transpl Infect Dis 2018 Dec 21;20(6):e12990. Epub 2018 Sep 21.

Department of Medicine, Division of Infectious Diseases & Global Medicine, College of Medicine, University of Florida, Gainesville, Florida.

Solid organ transplant patients are well established to be at risk of herpes simplex virus and varicella zoster virus infection and reactivation. We present a case of a 41-year-old woman with a history of pancreas and renal transplant who presented with what appeared to be disseminated herpes simplex virus or varicella zoster virus induced rash, but who was ultimately diagnosed and treated as linear IgA bullous dermatosis. This case alerts physicians to other non-infectious dermatoses as a cause of vesiculobullous rash in solid organ transplant patients. Read More

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http://dx.doi.org/10.1111/tid.12990DOI Listing
December 2018
6 Reads

Chronic Bullous Dermatosis of Childhood and the String of Pearls Sign.

J Pediatr 2018 11 29;202:325-325.e1. Epub 2018 Aug 29.

Pediatric Dermatology Bristol Royal Hospital for Children Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.jpeds.2018.07.070DOI Listing
November 2018
6 Reads

Diffuse vesiculobullous eruption with systemic findings.

Dermatol Online J 2018 May 15;24(5). Epub 2018 May 15.

Naval Health Clinic Quantico, Quantico, Virginia.

Drug induced linear IgA bullous dermatosis (LABD) is a rare blistering disease that has been shown to be associated with the use of various medications. Although rarely seen together, some of the medications associated with LABD can lead to the syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which presents with fever, cutaneous eruption, and multi-organ involvement. We present a patient who developed fever and a generalized vesiculobullous eruption after recently starting amlodipine and meloxicam. Read More

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May 2018
27 Reads

Bullous disorders associated with anti-PD-1 and anti-PD-L1 therapy: A retrospective analysis evaluating the clinical and histopathologic features, frequency, and impact on cancer therapy.

J Am Acad Dermatol 2018 Dec 17;79(6):1081-1088. Epub 2018 Jul 17.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Background: Bullous disorders associated with anti-programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) therapy are increasingly reported and may pose distinct therapeutic challenges. Their frequency and impact on cancer therapy are not well established.

Objective: To evaluate the clinical and histopathologic findings, frequency, and impact on cancer therapy of bullous eruptions due to anti-PD-1/PD-L1 therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183227
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http://dx.doi.org/10.1016/j.jaad.2018.07.008DOI Listing
December 2018
5 Reads

The Value of Type IV Collagen Immunohistochemical Staining in the Differential Diagnosis of Autoimmune Subepidermal Bullous Diseases.

Acta Dermatovenerol Croat 2018 Jun;26(2):133-138

Hai-Jin Park, MD, Inje Univ. Ilsan Paik Hospital, 170 Juwha-Ro, Ilsanseo-gu, Goyang, Gyeonggi-do, Korea;

Autoimmune subepidermal bullous diseases (AISBDs) exhibit various clinical presentations, histological appearances, prognoses, and responses to treatment. Many diagnostic techniques, such as direct immunofluorescence (IF), indirect salt-split skin IF, and enzyme-linked immunosorbent assays, are used in the differential diagnoses of AISBDs. However, these techniques require fresh frozen tissue, expensive laboratory equipment, and sophisticated laboratory techniques. Read More

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June 2018
7 Reads

Adult linear IgA bullous dermatosis: report of three cases.

An Bras Dermatol 2018 Jun;93(3):435-437

Department of Dermatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001096PMC
June 2018
22 Reads

Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

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April 2018
23 Reads

Drug-induced linear IgA bullous dermatosis in a patient with a vancomycin-impregnated cement spacer.

Cutis 2018 Apr;101(4):293-296

Division of Dermatology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin. Read More

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April 2018
5 Reads

Previously misdiagnosed linear IgA dermatosis resolved with dapsone.

BMJ Case Rep 2018 Apr 25;2018. Epub 2018 Apr 25.

Harvard University, Cambridge, Massachusetts, USA.

This is the case of a 25-year-old African American woman with a 3-week history of itching with burning, blistering lesions on her torso and extremities. Medical history was unremarkable. Medical treatments included three visits to urgent care, where she was treated with antivirals, oral and topical steroids, antibiotics and antifungals unsuccessfully. Read More

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http://dx.doi.org/10.1136/bcr-2017-220623DOI Listing
April 2018
5 Reads

Linear IgA bullous dermatosis induced by diclofenac sodium.

Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):496-497

Department of Dermatology and S.T.D., Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_100_17DOI Listing
November 2018
4 Reads
1.325 Impact Factor

Annular paraneoplastic bullous pemphigoid mimicking linear IgA bullous dermatosis in a 40-year-old patient.

J Dtsch Dermatol Ges 2018 Apr 26;16(4):482-484. Epub 2018 Mar 26.

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan.

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http://dx.doi.org/10.1111/ddg.13482DOI Listing
April 2018
2 Reads

Blistering diseases in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):231-238. Epub 2017 Oct 3.

Department of Dermatovenereology, University Hospital Center Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address:

Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.014DOI Listing
September 2018
13 Reads

Effectiveness and Safety of Rituximab in Recalcitrant Pemphigoid Diseases.

Front Immunol 2018 19;9:248. Epub 2018 Feb 19.

Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Introduction: Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited.

Objective: To assess the effectiveness and safety of RTX in pemphigoid diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827539PMC
March 2019
8 Reads

Uncomplicated Neonatal Linear IgA Bullous Dermatosis: A Case Report.

J Cutan Med Surg 2018 Jul/Aug;22(4):431-434. Epub 2018 Mar 5.

3 Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada.

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http://journals.sagepub.com/doi/ 10.1177/1203475418760458
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http://dx.doi.org/10.1177/1203475418760458DOI Listing
December 2018
15 Reads

Trimethoprim-sulfamethoxazole-induced linear IgA bullous disease presenting as toxic epidermal necrolysis.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, Hôpital Nord, University of Amiens, Amiens, France.

Background: Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disorder characterized by linear IgA deposits along the dermoepidermal junction. Usually idiopathic, LABD can be drug-induced.

Objective: To report the atypical characteristics of a case of trimethoprim-sulfamethoxazole-induced LABD presenting as toxic epidermal necrolysis (TEN). Read More

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August 2017
2 Reads

A toxic epidermal necrolysis-like presentation of linear IgA bullous dermatosis treated with dapsone.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, Baylor College of Medicine, Houston, Texas.

Linear IgA bullous dermatosis is a rare autoimmune vesiculobullous disease characterized by linear deposition of IgA along the basement membrane zone. It is classically idiopathic, but may also arise secondary to drug exposure. A heterogeneous spectrum of clinical features has been described, including a rare, morbid variant mimicking toxic epidermal necrolysis. Read More

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August 2017
12 Reads

Infantile bullous pemphigoid with "string of pearls sign".

Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.

Department of Dermatology, Centro Hospitalar do Porto, Portugal.

Bullous pemphigoid (BP) is an immune mediated bullous disease that is manifested by urticarial plaques with superimposed subepidermal blisters and significant pruritus. It is generally found in the elderly, but is rare in the pediatric population. A 5-month-old girl previously diagnosed with hand-foot-mouth disease was examined in our dermatology department owing to vesicles and bullae, initially located to the hands and feet, which progressed with new lesions. Read More

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July 2017
16 Reads

Child With Diffuse Bullous Rash.

Ann Emerg Med 2018 Mar;71(3):293-336

Department of Emergency Medicine, Division of Pediatric Emergency Medicine, University of Florida, Gainesville, FL.

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http://dx.doi.org/10.1016/j.annemergmed.2017.08.069DOI Listing

Flame figures in linear IgA bullous dermatosis: a novel histopathologic finding.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School, Boston, Massachusetts.

Background: Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease usually with a neutrophil rich inflammatory infiltrate, and characterized by linear IgA deposition at the basement membrane zone (BMZ), and neutrophil predominant dermal inflammation. We report a case of LABD with numerous eosinophils and flame figure formation, a unique histopathologic finding not previously reported. A 69-year-old woman presented with a rapidly progressive, intensely pruritic rash over forearms, breasts, axillae, hips, and thighs. Read More

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November 2017
1 Read

Sublamina densa-type linear IgA bullous dermatosis with IgA autoantibodies specific for type VII collagen: a case report and clinicopathological review of 32 cases.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Department of Dermatology, Division of Medical Sciences, University of Fukui, Fukui, Japan.

Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disorder characterized by linear deposits of IgA at the basement membrane zone(BMZ) and/or by circulating IgA anti-BMZ antibodies. Comparing with other immuno-bullous diseases, LABD represents a heterogeneous disease entitywith diversity of pathogenic IgA autoantibodies to different hemidesmosomal antigens and an association with malignancies and occasional drug use. We herein present an 82-year-old Japanese man with LABD, whose indirect immunofluorescence using 1M NaCl-split skin showed positive staining for IgA at the dermal side alone. Read More

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November 2017
7 Reads

Vancomycin Mediates IgA Autoreactivity in Drug-Induced Linear IgA Bullous Dermatosis.

J Invest Dermatol 2018 07 2;138(7):1473-1480. Epub 2018 Feb 2.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Vancomycin (VCM) is known to induce linear IgA bullous dermatosis (LAD). However, in contrast to conventional LAD, in which circulating IgA autoantibodies against basement membrane proteins are commonly detected, patient sera from VCM-induced LAD yields negative results in indirect immunofluorescence microscopy, and the targeted autoantigen remains undetermined. By using sera from a typical patient with VCM-induced LAD, we identified that co-incubation of sera with VCM resulted in linear IgA deposition at the basement membrane zone by indirect immunofluorescence. Read More

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http://dx.doi.org/10.1016/j.jid.2017.12.035DOI Listing
July 2018
6 Reads

Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross-sectional study.

Oral Dis 2018 Jul 16;24(5):802-808. Epub 2018 Apr 16.

Department of Oral and Maxillofacial Surgery, Oral Medicine, and Periodontics, School of Dentistry, The University of Jordan, Amman, Jordan.

Objectives: To describe the natural history and factors influencing diagnostic delays among patients with autoimmune blistering diseases of the mouth.

Materials And Methods: In this cross-sectional study, 27 newly diagnosed patients were interviewed, and professional and patient delays were calculated. Disease extent and severity scores were determined using Saraswat scoring system. Read More

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http://dx.doi.org/10.1111/odi.12839DOI Listing
July 2018
3 Reads

Skin and coeliac disease, a lot to think about: a case series.

BMJ Case Rep 2018 Jan 4;2018. Epub 2018 Jan 4.

Pediatric Department, Hospital of Divino Espírito Santo of Ponta Delgada, Ponta Delgada - São Miguel, Azores, Portugal.

Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. Read More

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http://dx.doi.org/10.1136/bcr-2017-222797DOI Listing
January 2018
9 Reads

[Humoral immune diseases: Cutaneous vasculitis and auto-immune bullous dermatoses].

Authors:
Janine Wechsler

Ann Pathol 2018 Feb 27;38(1):31-42. Epub 2017 Dec 27.

Département de pathologie, service d'anatomie et de cytologie pathologiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

Humoral immunity is the cause of multiple diseases related to antibodies (IgA, IgG, IgM) produced by the patient. Two groups of diseases are identified. The first group is related to circulating antigen-antibody complexes. Read More

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http://dx.doi.org/10.1016/j.annpat.2017.11.003DOI Listing
February 2018
7 Reads

Linear IgA dermatosis: An atypical manifestation of a rare disease.

Pediatr Neonatol 2018 06 7;59(3):324-325. Epub 2017 Dec 7.

Dermatology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal.

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http://dx.doi.org/10.1016/j.pedneo.2017.11.022DOI Listing
June 2018
5 Reads

The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.

An Bras Dermatol 2017 ;92(5 Suppl 1):145-147

Dermatology Outpatient Clinic at Hospital do Açúcar de Alagoas do Centro Universitário Tiradentes, Maceió, Alagoas (AL), Brazil.

Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20174510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726706PMC
March 2018
10 Reads

Spectrum of Autoimmune Bullous Diseases in Northern Greece. A 4-year Retrospective Study and Review of the Literature.

Acta Dermatovenerol Croat 2017 Oct;25(3):195-201

Foteini Lamprou, MD, MSc, PhD candidate, 2nd University Department of Dermatology Papageorgiou General Hospital Aristotle University of Thessaloniki, Ring Road, Municipality of Pavlos Melas, Area of N. Efkarpia, 56403 Thessaloniki, Greece;

Bullous Diseases Unit at the 2nd Department of Dermatology and Venereology, Aristotle University of Thessaloniki was founded with the aim to provide the optimal diagnostic approach and treatment of patients with autoimmune bullous diseases (AΙBD). We processed all AIBD files of patients diagnosed from 2011 to 2014 in order to record all epidemiological data and therapeutic manipulations during monitoring. 57 patients were diagnosed with intraepidermal and 62 with subepidermal bullous diseases. Read More

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October 2017
16 Reads

Production of Neoepitopes by Dynamic Structural Changes on BP180/Type XVII Collagen.

J Invest Dermatol 2017 12;137(12):2462-2464

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Linear IgA bullous dermatosis is characterized by IgA autoantibodies reactive with LAD-1 and LABD97, truncated forms of BP180 (type XVII collagen), but not with full-length BP180. Toyonaga et al. determined that cleavage within both the C-terminal region and NC16A domain plays a role in exposure of neoepitopes on the 15th collagenous domain of BP180. Read More

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http://dx.doi.org/10.1016/j.jid.2017.09.001DOI Listing
December 2017
2 Reads

Subepidermal autoimmune bullous diseases: overview, epidemiology, and associations.

Authors:
Khalaf Kridin

Immunol Res 2018 02;66(1):6-17

Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel.

Subepidermal autoimmune bullous diseases of the skin and mucosae comprise a large group of chronic diseases, including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, linear IgA bullous dermatosis, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. These diseases are characterized by an antibody response toward structural components of the basement membrane zone, resulting in subepidermal blistering. The epidemiological features of these diseases vary substantially in different regions of the world. Read More

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http://dx.doi.org/10.1007/s12026-017-8975-2DOI Listing
February 2018
42 Reads

Linear IgA bullous dermatosis: A rare manifestation of vancomycin hypersensitivity.

Ann Allergy Asthma Immunol 2018 Jan 8;120(1):101-102. Epub 2017 Nov 8.

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.anai.2017.10.007DOI Listing
January 2018
8 Reads

Blistering rash in a young male child.

S Afr Med J 2017 Jun 30;107(7):578-580. Epub 2017 Jun 30.

Paediatrics Department, Leratong Hospital, Johannesburg, South Africa.

A 3-year-old child was brought to the casualty department at Leratong Hospital, Johannesburg, South Africa, with severe bullous eruptions on the distal portions of both the upper and lower limbs. He had visited three different general practitioners prior to presentation and had been given several drugs and ointments, including three different classes of antibiotics. During his admission, the diagnosis of linear IgA bullous dermatitis was made. Read More

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http://dx.doi.org/10.7196/SAMJ.2017.v107i7.12407DOI Listing
June 2017
10 Reads

Linear IgA bullous dermatosis associated with amyotrophic lateral sclerosis.

Authors:
S Y Yang S C Hu

Clin Exp Dermatol 2018 Jan 12;43(1):70-71. Epub 2017 Oct 12.

Department of Dermatology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung, 807, Taiwan.

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http://dx.doi.org/10.1111/ced.13274DOI Listing
January 2018
6 Reads

[Generalized Bullous Eruption During Treatment with Vancomycin].

Acta Med Port 2017 08 31;30(7-8):586. Epub 2017 Aug 31.

Serviço de Dermatologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.

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http://dx.doi.org/10.20344/amp.8786DOI Listing
August 2017
7 Reads