656 results match your criteria Linear IgA Dermatosis


Idiopathic linear IgA bullous dermatosis treated with prednisone.

BMJ Case Rep 2021 May 12;14(5). Epub 2021 May 12.

Department of Medicine, Michigan State University College of Human Medicine, Lansing, Michigan, USA.

We present a case of a 43-year-old man with a medical history of paroxysmal atrial fibrillation that presented with acute onset generalised vesiculobullous rash of 1-week duration. The rash was initially noticed on his groin and then spread to his hands, feet and mucosal surfaces. Laboratory tests were unremarkable, including an extensive infection aetiology work-up. Read More

View Article and Full-Text PDF

A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.

Acta Dermatovenerol Croat 2020 Dec;28(4):249-250

Hisayoshi Imanishi, MD, PhD, Division of Dermatology, Daito Central Hospital, 2-1-11 Ono, Daito, Osaka 574-0042, Japan;

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive treatment for, e.g. Read More

View Article and Full-Text PDF
December 2020

Diffuse cutaneous mastocytosis masquerading as linear IgA bullous dermatosis of childhood.

Dermatol Reports 2021 Mar 17;13(1):9021. Epub 2021 Mar 17.

Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Diffuse cutaneous mastocytosis is a rare form of cutaneous mastocytosis that can appear in heterogeneous clinical presentations, including eruption of papules, erythematous plaques, blisters, and erythroderma. We report a 1.5- year-old boy who presented with itchy wheals and blisters spreading on his body. Read More

View Article and Full-Text PDF

Rare case of linear IgA bullous dermatosis showing IgA, IgG and IgM reactivity.

Australas J Dermatol 2021 May 17;62(2):e361-e362. Epub 2021 Mar 17.

National Skin Centre, Singapore, Singapore.

View Article and Full-Text PDF

Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.

J Am Acad Dermatol 2021 Jul 5;85(1):1-14. Epub 2021 Mar 5.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Subepithelial autoimmune blistering dermatoses are a group of rare skin disorders that are characterized by the disruption of the dermal-epidermal junction through the action of autoantibodies. The third article in this continuing medical education series explores the background, epidemiology, clinical features, and diagnostic criteria of each of the major subepithelial autoimmune blistering dermatoses, including bullous pemphigoid, pemphigoid gestationis, lichen planus pemphigoides, mucous membrane pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis. Read More

View Article and Full-Text PDF

Subepithelial autoimmune bullous dermatoses disease activity assessment and therapy.

J Am Acad Dermatol 2021 Jul 5;85(1):18-27. Epub 2021 Mar 5.

Epiphany Dermatology, Dallas, Texas. Electronic address:

Subepidermal (subepithelial) autoimmune blistering dermatoses are a group of rare skin disorders characterized by the disruption of the dermal-epidermal junction through the action of autoantibodies. The fourth article in this continuing medical education series presents the current validated disease activity scoring systems, serologic parameters, treatments, and clinical trials for bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, bullous systemic lupus erythematosus, anti-p200 pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis. Read More

View Article and Full-Text PDF

A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid.

Dermatopathology (Basel) 2021 Feb 23;8(1):33-36. Epub 2021 Feb 23.

Dermatology-IRCCS Policlinico di Sant'Orsola-Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.

Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immunofluorescence (linear deposition of IgG at the dermo-epidermal junction). Read More

View Article and Full-Text PDF
February 2021

Immunologic overlap in a case of linear IgG/IgA bullous dermatosis responsive to rituximab.

JAAD Case Rep 2021 Mar 11;9:57-60. Epub 2021 Jan 11.

Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

View Article and Full-Text PDF

A Case of Linear IgA Bullous Dermatosis Successfully Treated with Omalizumab.

Indian J Dermatol 2020 Nov-Dec;65(6):543-545

Department of Dermatology, Venereology and Leprosy, Gujarat Cancer Society Medical College Hospital and Research Center, Ahmedabad, Gujarat, India. E-mail:

View Article and Full-Text PDF
January 2021

A Case of Linear IgA Bullous Dermatosis Induced by Aspirin Therapy.

Iran J Allergy Asthma Immunol 2020 Oct 18;19(5):550-554. Epub 2020 Oct 18.

Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran.

Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease that may be triggered by some diseases and medications. For the latter one, non-steroidal anti-inflammatory drugs (NSAIDs) have been identified as one of the potential causative agents to develop LABD. Here, a rare case of drug-induced LABD is introduced. Read More

View Article and Full-Text PDF
October 2020

Vancomycin-induced linear IgA bullous dermatosis.

Proc (Bayl Univ Med Cent) 2020 Aug 26;34(1):83-84. Epub 2020 Aug 26.

Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.

Adverse medication side effects are not uncommon in the inpatient setting, where polypharmacy is the norm. Linear IgA bullous dermatosis (LABD) can be a cutaneous side effect of commonly used inpatient medications, such as vancomycin. Symptoms of LABD can be severe, and proper recognition of this drug-induced disease is important to ensuring proper treatment, including the removal of the inciting agent. Read More

View Article and Full-Text PDF

Norfloxacin-Induced Linear IgA Dermatosis.

Skinmed 2020 1;18(6):374-377. Epub 2020 Dec 1.

Department of Pathology, University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi, India.

A 60-year-old cachexic man visited the dermatology outpatient department with fluid-filled lesions on much of his body. He had an intermittent high-grade fever, diarrhea, and vomiting for the past 2 months associated with weight loss and decreased appetite. He admitted to having taken norfloxacin 400 mg twice daily for 3 days for diarrhea, 5 days prior to the onset of the lesions. Read More

View Article and Full-Text PDF
December 2020

Helicobacter pylori and skin disorders: a comprehensive review of the available literature.

Eur Rev Med Pharmacol Sci 2020 12;24(23):12267-12287

Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy.

Helicobacter pylori is a Gram-negative bacterium identified for the first time about 30 years ago and commonly considered as the main pathogenic factor of gastritis and peptic ulcer. Since then, it was found to be associated with several gastrointestinal and extra-gastrointestinal diseases. Helicobacter pylori is also associated with many skin disorders including, but not limited to, chronic urticaria, rosacea, lichen planus, atopic dermatitis, psoriasis, pemphigus vulgaris, vitiligo, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, primary cutaneous marginal zone B-cell lymphomas and cutaneous T-cell pseudolymphoma. Read More

View Article and Full-Text PDF
December 2020

A bullous rash.

Arch Dis Child Educ Pract Ed 2020 Nov 19. Epub 2020 Nov 19.

Pediatric Department, University of Trieste, Trieste, Italy.

A 3-year-old boy presented with a 5-day history of bullous skin lesions localised mainly in the upper and lower limbs and in the genital region (figure 1). Lesions were not pruritic nor painful and showed a central crust. There was no family history of skin disorders or autoimmune diseases. Read More

View Article and Full-Text PDF
November 2020

Vancomycin-Induced Linear IgA Bullous Dermatosis.

N Engl J Med 2020 Oct;383(16):1577

Mayo Clinic, Rochester, MN

View Article and Full-Text PDF
October 2020

Intravenous Immunoglobulins in a Series of 32 Rare and Recalcitrant Immune Dermatoses.

Acta Derm Venereol 2020 Oct 21;100(17):adv00298. Epub 2020 Oct 21.

Division of Allergy and Immunology, Charité - Universitätsmedizin Berlin, DE-10117 Berlin, Germany.

Intravenous immunoglobulins are an effective and well-tolerated treatment option for immune dermatological diseases. However, they are primarily used to treat diseases with a severe course and are mostly used off-label. Therefore, it is important to document case series on the use of intravenous immunoglobulins in rare immune dermatological diseases. Read More

View Article and Full-Text PDF
October 2020

Spectrum of autoimmune bullous diseases among children in Kuwait.

Pediatr Dermatol 2021 Jan 11;38(1):50-57. Epub 2020 Oct 11.

As'ad Al-Hamad Dermatology Center, Salmiya, Kuwait.

Background: Autoimmune bullous diseases (AIBD) are rare among children. The data describing the overall spectrum and prognosis of pediatric AIBD (pAIBD) are scarce, and there are no established treatment guidelines.

Objectives: The present study examined the spectrum, clinical characteristics, and long-term prognosis of pAIBD in a tertiary care pediatric dermatology unit. Read More

View Article and Full-Text PDF
January 2021

Alterations of Total Serum Immunoglobulin Concentrations in Pemphigus and Pemphigoid: Selected IgG2 Deficiency in Bullous Pemphigoid.

Front Med (Lausanne) 2020 2;7:472. Epub 2020 Sep 2.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigus and pemphigoid diseases are organ-specific autoimmune diseases of the skin and/or mucous membranes, which are caused by autoantibodies targeting structural proteins of the skin. In other autoimmune diseases, a high prevalence of primary antibody deficiencies was noted. Conversely, a high prevalence of autoimmune diseases is reported in patients with primary antibody deficiencies. Read More

View Article and Full-Text PDF
September 2020

Comment on "Dermatitis herpetiformis in an African woman", the importance of direct immunofluorescence assay.

Pan Afr Med J 2020 20;36:196. Epub 2020 Jul 20.

U.O. Dermatology I, P.O. Piero Palagi, USL Toscana Centro, University of Florence, Florence, Italy.

View Article and Full-Text PDF

Acquired Reactive Perforating Collagenosis Associated with Linear Immunoglobulin A Bullous Disease.

Acta Derm Venereol 2020 Sep 23;100(16):adv00268. Epub 2020 Sep 23.

Department of Dermatology, Children's Hospital of Chongqing Medical University, 400014 ChongQing, China. E-mail:

View Article and Full-Text PDF
September 2020

Giant conjunctival bulla: A rare manifestation of autoimmune fibrosing conjunctivitis.

J Fr Ophtalmol 2020 Oct 20;43(8):e267-e269. Epub 2020 Aug 20.

Hospital Clinic Barcelona, Universitat de Barcelona, C. de Villarroel, 170, 08036 Barcelona, Espagne.

View Article and Full-Text PDF
October 2020

Linear IgA bullous dermatosis: A rare manifestation of amoxicillin-clavulanic acid treatment.

Dermatol Ther 2020 11 9;33(6):e14187. Epub 2020 Sep 9.

Department of Dermatology, University of Sousse, Farhat Hached Hospital, Sousse, Tunisia.

View Article and Full-Text PDF
November 2020

Successful treatment of a patient with linear IgA bullous dermatosis limited to oral, hypopharyngeal, and laryngeal mucosa with dapsone.

Dermatol Ther 2020 11 3;33(6):e14127. Epub 2020 Sep 3.

School of Medicine, Department of Ear, Nose & Throat, Hacettepe University, Ankara, Turkey.

View Article and Full-Text PDF
November 2020

'String of Pearls' Sign Revealing Linear IgA Bullous Disease.

Am J Med 2021 02 28;134(2):e135-e136. Epub 2020 Jul 28.

Unit of Infectious Diseases, Department of Internal Medicine, Hospital Universitario de Gran Canaria Dr. Negrín, Spain.

View Article and Full-Text PDF
February 2021

Pruritic annular and vesicular eruption on trunk and extremities.

Clin Case Rep 2020 Jul 12;8(7):1301-1303. Epub 2020 Apr 12.

Dermatology Department University Hospital of Heraklion Crete Greece.

We report a case of linear IgA bullous dermatosis, a rare autoimmune blistering disorder that usually presents with the abrupt onset of tense bullae. We also emphasize the importance of direct immunofluorescence for the definitive diagnosis. Read More

View Article and Full-Text PDF

Neonatal Autoimmune Subepidermal IgG/IgA Blistering Disease With Severe Laryngeal and Esophageal Involvement: A Report of a Case and Review of the Literature.

Am J Dermatopathol 2020 Oct;42(10):783-786

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Neonatal autoimmune subepidermal blistering disease is rare. Mucosal involvement is more common in neonatal linear immunoglobulin A (IgA) bullous dermatosis. We describe a neonate with subepidermal cutaneous blistering disease with severe laryngeal and esophageal involvement leading to acute respiratory distress. Read More

View Article and Full-Text PDF
October 2020

Linear IgA Bullous Dermatosis.

N Engl J Med 2020 Jun;382(23):2248

Hospital Universitario 12 de Octubre, Madrid, Spain

View Article and Full-Text PDF

IgA pemphigus and linear IgA bullous dermatosis in a patient with ulcerative colitis.

Australas J Dermatol 2020 Nov 17;61(4):e443-e445. Epub 2020 May 17.

Division of Dermatology, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.

View Article and Full-Text PDF
November 2020

Bullous lesions in a young adolescent postrenal transplant.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):553-555

Division of Pediatric Nephrology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

Kidney transplant recipients frequently suffer from skin infections and malignancies. New dermatosis can appear after transplantation. Although children are maintained on varying degrees of chronic immunosuppression, there is still a possibility of autoimmune blistering skin conditions, which can pose a diagnostic challenge in terms of clinical presentation. Read More

View Article and Full-Text PDF