698 results match your criteria Linear IgA Dermatosis


Atezolizumab-induced linear IgA bullous dermatosis.

Br J Dermatol 2022 Jun 7. Epub 2022 Jun 7.

Department of Dermatology, Royal Marsden Hospital NHS Trust, London, UK.

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Vancomycin-induced linear IgA bullous dermatosis.

Med Clin (Barc) 2022 Jun 1. Epub 2022 Jun 1.

Servicio de Dermatología, Hospital Universitario Miguel Servet, IIS Aragón, Universidad de Zaragoza, Zaragoza, España.

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Ulcerative colitis complicated with linear immunoglobulin A bullous dermatosis.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Japan

Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare disorder involving subepidermal blistering characterised by IgA deposition along the basement membrane. The clinical features of LABD are variable but can include bullae, vesicles and erythematous lesions. Histopathology reveals formation of subepidermal bullae and linearly deposition of IgA in the basement membrane of the epidermis. Read More

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Annular bullous pemphigoid: A case report and review of literature.

SAGE Open Med Case Rep 2022 21;10:2050313X221093128. Epub 2022 Apr 21.

Division of Dermatology, Hôpital du Sacré-Cœur de Montréal, Université de Montréal, Montreal, QC, Canada.

Bullous pemphigoid is an autoimmune blistering disease that primarily affects the geriatric population. It often presents as urticarial erythematous plaques, which evolve into subepidermal blisters accompanied by pruritus. Although rare, clinical variants of bullous pemphigoid have been documented. Read More

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Idiopathic linear IgA bullous dermatosis with mucosal involvement.

J Osteopath Med 2022 Apr 1;122(7):375-376. Epub 2022 Apr 1.

Kansas City University-Graduate Medical Education Consortium/Advanced Dermatology and Cosmetic Surgery, Oviedo, FL, USA.

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Oral immune-mediated disorders with malignant potential/association: An overview.

Dis Mon 2022 Mar 22:101349. Epub 2022 Mar 22.

College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT, United States. Electronic address:

A group of oral disorders or conditions, which may result from, or could be triggered by an abnormality in the normal immune response of an individual are known as oral immune-mediated disorders. Some of these disorders have malignant potential, while others are associated with malignancy. In this overview, we will discuss a few of the oral diseases (such as oral lichen planus, primary Sjogren's syndrome, systemic lupus erythematosus, dermatitis herpetiformis, and linear immunoglobulin A bullous dermatosis, to name a few), which are caused due to irregularity in the immune system and are either associated with malignancy or capable of undergoing malignant transforming, thereby increasing the morbidity and mortality rate. Read More

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Linear IgA Bullous Dermatosis.

J Cutan Med Surg 2022 Mar 23:12034754221088563. Epub 2022 Mar 23.

201358 Sanitary Dermatology Outpatient Clinic, Health Department of Rio Grande do Sul State - SES/RS, Porto Alegre, RS, Brazil.

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Pyoderma gangrenosum occurring 7 years after onset of linear IgA bullous dermatosis in a young woman.

Clin Exp Dermatol 2022 Mar 17. Epub 2022 Mar 17.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

We present a case of coexistence of pyoderma gangrenosum (PG) and linear IgA bullous dermatosis (LABD), with a 7-year interval between them. This is the first case of coexisting PG and LABD, to our knowledge. Read More

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Linear IgA/IgG bullous dermatosis successfully treated with omalizumab: A case report.

Clin Case Rep 2022 Mar 8;10(3):e05368. Epub 2022 Mar 8.

Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark.

Linear IgA/IgG bullous dermatosis (LAGBD) is a rare, autoimmune blistering skin disease. We report a case of LAGBD in a 70-year-old woman. All common treatments were discontinued due to side effects or lack of treatment response. Read More

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Autoimmune mucocutaneous blistering diseases after SARS-Cov-2 vaccination: A Case report of Pemphigus Vulgaris and a literature review.

Pathol Res Pract 2022 Apr 5;232:153834. Epub 2022 Mar 5.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, via Pansini 5, 80131 Naples, Italy.

Background: Cases of severe autoimmune blistering diseases (AIBDs) have recently been reported in association with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.

Aims: To describe a report of oropharyngeal Pemphigus Vulgaris (OPV) triggered by the mRNABNT162b2 vaccine (Comirnaty®/ Pfizer/ BioNTech) and to analyze the clinical and immunological characteristics of the AIBDs cases reported following the SARS-CoV-2 vaccination.

Methods: The clinical and immunological features of our case of OPV were documented. Read More

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Linear IGA bullous dermatosis potentially triggered by vaccination.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:20587384211021218

Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. Read More

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Nutrition and bullous diseases.

Clin Dermatol 2022 Mar-Apr;40(2):156-165. Epub 2021 Nov 19.

Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut, USA. Electronic address:

Although relatively uncommon, autoimmune bullous diseases carry the risk of increased mortality and can significantly impact quality of life. This group of diseases is broad and encompasses subepidermal conditions such as bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis, and linear IgA bullous dermatosis, as well as intraepidermal conditions such as pemphigus and its variants. The pathophysiology of each condition is incompletely understood but broadly involves the formation of autoantibodies targeting skin adhesion proteins, a process that relies on a complex interplay between a dysregulated immune system, genetic predisposition, and environmental factors. Read More

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Linear IgA bullous dermatosis following Oxford AstraZeneca COVID-19 vaccine.

Clin Exp Dermatol 2022 Mar 8;47(3):611-613. Epub 2021 Dec 8.

Department of Dermatology and Venereology, Ibn Rochd University Hospital, Casablanca, Morocco.

A case of linear IgA bullous dermatosis developing 3 days after the second dose of Oxford AstraZeneca COVID-19 vaccine in an adult patient, suggesting a possible causal association. It is worth keeping in mind that COVID-19 vaccination could induce immune-mediated bullous disease in susceptible people. Read More

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Coexistence of psoriasis and linear IgA disease: An uncommon presentation.

Indian J Dermatol Venereol Leprol 2021 Jan-Feb;88(1):101-103

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

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Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay.

JAMA Dermatol 2021 Nov;157(11):1343-1348

Massachusetts General Physician Organization Dermatopathology Associates, Newton, Massachusetts.

Importance: Dermatologists submit direct immunofluorescence (DIF) biopsies on a daily basis, using an assay detecting immunoreactant deposition with a panel that has traditionally comprised immunoglobulin (Ig) G, IgA, IgM, C3, and fibrin, with or without albumin antibodies.

Objectives: To evaluate and compare the frequency of immunoreactants in DIF biopsies submitted over an 8-year period and assess use by dermatologists based on clinical impression.

Design, Setting, And Participants: A quality improvement study was conducted in a community outreach reference laboratory associated with a large academic medical center. Read More

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November 2021

Cefixime-induced linear IgA bullous dermatosis: a rare cause of mucocutaneous bullous eruption in a patient on hemodialysis.

Int J Dermatol 2022 06 29;61(6):763-765. Epub 2021 Sep 29.

Department of Dermatology, Venereology, and Leprosy, RG Kar Medical College and Hospital, Kolkata, West Bengal, India.

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Symblepharon in Linear IgA Bullous Dermatosis.

N Engl J Med 2021 Sep;385(13):1219

Geisinger Eye Institute, Danville, PA

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September 2021

A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.

Acta Dermatovenerol Croat 2021 Jul;29(2):116-117

Satoko Minakawa, MD, PhD, Department of Dermatology Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan;

Dear Editor, Linear immunoglobulin (Ig) A bullous dermatosis (LABD), one subtype of subepidermal autoimmune bullous skin diseases (AIBDs), is characterized by linear deposit of only IgA along the basement membrane zone (BMZ) on direct immunofluorescence (DIF) (1,2). Patients showing linear deposits of both IgA and IgG are diagnosed with linear IgA/IgG bullous dermatosis (LAGBD) (3,4). Dermatitis herpetiformis (DH) is another type of subepidermal AIBD characterized by clinically pruritic erythematous skin lesions with vesicles on the elbows, knees, and buttocks with granular IgA deposits of IgA by DIF (5). Read More

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Anti-laminin 332 antibody detection using biochip immunofluorescence microscopy in a real-life cohort of Italian patients with mucous membrane pemphigoid.

Eur J Dermatol 2021 Aug 26. Epub 2021 Aug 26.

Section of Dermatology, Department of health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Mucous membrane pemphigoid (MMP) with anti-laminin 332 autoantibodies may be associated with malignancies, however, current serological assays have considerable limitations. At present, no commercial test for anti-laminin 332 antibodies is available, restricting the diagnosis to specialized laboratories worldwide. Biochip immunofluorescence microscopy has shown promising results in selected cohorts of laminin 332-MMP patients. Read More

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Case of linear immunoglobulin A bullous dermatosis in a patient with prostate cancer.

J Dermatol 2021 Nov 29;48(11):e560-e561. Epub 2021 Aug 29.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Chuo, Japan.

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November 2021

Updates in the Diagnosis and Management of Linear IgA Disease: A Systematic Review.

Medicina (Kaunas) 2021 Aug 12;57(8). Epub 2021 Aug 12.

Department of Dermatology, Loma Linda University School of Medicine, Loma Linda, CA 92708, USA.

Linear IgA disease (LAD) is a rare autoimmune blistering disease with linear IgA deposits along the basement membrane zone. Direct immunofluorescence remains the gold standard for diagnosis, but other diagnostic measures reported in recent literature have proven useful in the setting of inconclusive preliminary results. Dapsone is a commonly used treatment, but many therapeutic agents have emerged in recent years. Read More

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Mucosal linear IgA disease with esophageal involvement responsive to ustekinumab.

JAAD Case Rep 2021 Sep 10;15:4-6. Epub 2021 Jul 10.

Department of Dermatology, University of Utah, Salt Lake City, Utah.

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September 2021

Blister fluid is a useful diagnostic tool for diagnosis of vancomycin-induced linear IgA bullous dermatosis.

J Dermatol 2021 Nov 8;48(11):e543-e544. Epub 2021 Aug 8.

Faculty of Medicine, Department of Dermatology, Toho University School of Medicine, Tokyo, Japan.

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November 2021

Genetic and acquired blistering disorders of pediatric age group: An experience from Eastern India.

Indian J Pathol Microbiol 2021 Jul-Sep;64(3):509-517

Department of Anatomy, Institute of Postgraduate Medical Education and Research (IPGMER), Kolkata, West Bengal, India.

Introduction: Blistering or vesiculobullous disorders in pediatric population are either immunobullous or mechanobullous. Spectrum was analyzed using demographic details, clinical features, histopathology, direct immunofluorescence (DIF) and Immunofluorescence mapping (IFM).

Methodology: This was a single institution based observational study in children below 18 years. Read More

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November 2021

Tense blisters in a previously healthy young woman.

JAAD Case Rep 2021 Aug 24;14:108-110. Epub 2021 Jun 24.

Department of Dermatology, Medical College of Georgia at Augusta University, Augusta, Georgia.

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Neonatal Linear IgA Bullous Dermatosis Mediated by Breast Milk-Borne Maternal IgA.

JAMA Dermatol 2021 Sep;157(9):1107-1111

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Importance: Neonatal linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare disease that can be fatal when associated with respiratory failure. All previously reported cases of neonatal LABD have been in newborns with healthy asymptomatic mothers, and the pathogenic IgA was of unknown origin.

Objective: To clarify the origin of IgA associated with LABD in neonates born of healthy asymptomatic mothers. Read More

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September 2021