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    532 results match your criteria Linear IgA Dermatosis

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    Subepidermal autoimmune bullous diseases: overview, epidemiology, and associations.
    Immunol Res 2017 Nov 21. Epub 2017 Nov 21.
    Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel.
    Subepidermal autoimmune bullous diseases of the skin and mucosae comprise a large group of chronic diseases, including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, linear IgA bullous dermatosis, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. These diseases are characterized by an antibody response toward structural components of the basement membrane zone, resulting in subepidermal blistering. The epidemiological features of these diseases vary substantially in different regions of the world. Read More

    C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies.
    J Invest Dermatol 2017 Dec 24;137(12):2552-2559. Epub 2017 Aug 24.
    Department of Dermatology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan. Electronic address:
    Transmembrane collagen XVII (COL17) is a hemidesmosomal component of basal keratinocytes that can be targeted by autoantibodies in autoimmune blistering disorders, including linear IgA dermatosis (LAD). COL17 can be physiologically cleaved within the juxtamembranous extracellular NC16A domain, and LAD autoantibodies preferentially react with the processed ectodomains, indicating that the processing induces neoepitopes. However, the details of how neoepitopes develop have not been elucidated. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Linear IgA bullous dermatosis mimicking oral lichen planus.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):360-361
    Texas A&M Health Science Center College of Medicine (Shah, Parekh) and Department of Dermatology, Scott & White Memorial Hospital (Shah, Mohr, Parekh), Temple, Texas.
    Linear IgA bullous dermatosis (LABD) is an autoimmune disease characterized by blisters on the skin and mucous membranes. Polycyclic, grouped bullae on cutaneous skin are the most characteristic clinical feature of LABD. Lesions are often indistinguishable from bullous pemphigoid or may resemble dermatitis herpetiformis. Read More

    Linear immunoglobulin A/G bullous dermatosis associated with ulcerative colitis.
    J Dermatol 2017 Nov 17;44(11):1295-1298. Epub 2017 Jun 17.
    Department of Dermatology, Nihon University Hospital, Tokyo, Japan.
    Linear immunoglobulin (Ig)A/G bullous dermatosis (LAGBD) is an autoimmune bullous disease characterized by formation of subepidermal blisters and linear deposition of IgA and IgG antibodies along the basement membrane zone (BMZ). The association between linear IgA bullous dermatosis and ulcerative colitis (UC) is well recognized, but reports of UC-associated LAGBD are lacking. We have reported a 24-year-old man suffering from LAGBD associated with UC, which occurred before exacerbations of skin rash. Read More

    [A particular type of cicatricial Pemphigoid with unique IgA deposit].
    Pan Afr Med J 2017 13;26:136. Epub 2017 Mar 13.
    Université de Sousse, Tunisie.
    Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Read More

    Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.
    J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

    Linear immunoglobulin A dermatosis: A case report.
    Medwave 2017 Apr 4;17(3):e6901. Epub 2017 Apr 4.
    Facultad de Medicina, Universidad de Chile, Santiago, Chile.
    We present the case of a sixty five year old woman with two months history of pruritus and hyperpigmented annular lesions on the trunk, buttocks and upper extremities. In addition, she presents vesicles with healthy skin on the basis, in the flexor aspect of wrists. No evidence of mucosal involvement. Read More

    Human orf complicated by epidermolysis bullosa acquisita.
    Br J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Dermatology Department, Saint-Louis Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France.
    Orf is a DNA parapoxvirus transmitted to humans by contact with infected goats and sheep. Many complications have been reported after orf infection, including erythema multiforme. A few cases of autoimmune bullous dermatosis complicating orf disease have been reported to date. Read More

    Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):35-38
    Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
    Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. Read More

    Linear IgA and IgG bullous dermatosis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):32-34
    Hospital Federal de Bonsucesso (HFB) -Rio de Janeiro (RJ), Brazil.
    Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. Read More

    Linear immunoglobulin A dermatosis mimicking toxic epidermal necrolysis: a case report of etanercept treatment.
    Br J Dermatol 2017 Feb 21. Epub 2017 Feb 21.
    Departments of Dermatology, Hospital Universitario 12 de Octubre, I + 12 Research Institute, Universidad Complutense, Madrid, Spain.
    A 65-year-old pluripathological woman attended our hospital with a cutaneous eruption of sudden appearance after vancomycin treatment. She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions with mucosal lesions and positive Nikolsky sign. Under the initial clinical suspicion of toxic epidermal necrolysis (TEN), and considering the recent literature of successful use of etanercept in these cases, she was treated with a single dose of this antitumour necrosis factor (anti-TNF) agent. Read More

    A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis.
    Case Rep Dermatol Med 2017 10;2017:7318305. Epub 2017 Jan 10.
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
    Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. Read More

    Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap.
    Clin Exp Dermatol 2017 Apr 13;42(3):299-302. Epub 2017 Jan 13.
    Department of Dermatology, Alfred Hospital, Melbourne, VIC, Australia.
    Linear IgA bullous dermatosis (LABD) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation of this disease is heterogeneous. LABD clinically presenting as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is an infrequent, yet well-described phenomenon. Read More

    Bullous Dermatosis in an End-Stage Renal Disease Patient: A Case Report and Literature Review.
    Case Rep Nephrol 2016 24;2016:6713807. Epub 2016 Nov 24.
    Division of Nephrology and Hypertension, Department of Internal Medicine, Wayne State University Detroit Medical Center, Detroit, MI, USA.
    Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic possibilities, and subsequent rise of a puzzling diagnostic challenge. We describe an ESRD patient who presented with blistering, nonhealing ulcerative lesions with a diagnostic skin biopsy revealing a mixed pattern of linear IgA bullous dermatosis and dermatitis herpetiformis. Read More

    Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case series of 72 adults.
    Br J Dermatol 2017 Jul 15;177(1):212-222. Epub 2017 May 15.
    Referral Center for Autoimmune Blistering Diseases, Île-de-France, France.
    Background: Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune bullous disease (AIBD), for which the long-term evolution is poorly described.

    Objectives: To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD.

    Methods: This retrospective study, conducted in our AIBD referral centre, included adults, diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence. Read More

    A clinical and serological study of linear IgA bullous dermatosis without linear immunoglobulin deposition other than IgA at the basement membrane zone using direct immunofluorescence.
    Br J Dermatol 2017 Jul 22;177(1):152-157. Epub 2017 Mar 22.
    Department of Dermatology, Kurume University School of Medicine, Kurume 830-0011, Japan.
    Background: Linear IgA bullous dermatosis (LABD) is a heterogeneous disease. Different diagnostic criteria have been used in different reports.

    Objectives: To reappraise the characteristic features of LABD with only IgA deposition at the basement membrane zone (BMZ) with direct immunofluorescence (DIF). Read More

    Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans.
    J Dermatol 2017 Apr 3;44(4):461-464. Epub 2016 Dec 3.
    Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Bronchiolitis obliterans is a small-airway obstructive lung disease for which immunologically mediated pathogenesis is supposed. Frequent association of bronchiolitis obliterans with paraneoplastic pemphigus is well known, but its association with other autoimmune bullous diseases has not been reported except for a case of anti-laminin-332-type mucous membrane pemphigoid in a patient with chronic graft-versus-host disease. We report a case of non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans in a patient without transplantation. Read More

    Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment.
    Am J Clin Dermatol 2017 Feb;18(1):105-126
    Department of Dermatology, University of Illinois College of Medicine, UIC-Derm, MC624, 808 S. Wood Street, R380, Chicago, IL, 60612, USA.
    Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Read More

    [Topical corticosteroids as a therapeutic alternative in linear immunoglobulin A bullous dermatosis in childhood: case report].
    Arch Argent Pediatr 2016 Dec;114(6):e440-e443
    Servicio de Dermatología, Hospital García Orcoyen, Estella, España.
    Linear immunoglobulin A dermatosis of childhood is a rare autoimmune disorder. Its etiology remains unknown, although it has been linked to drugs, infections, immunological diseases and lymphoproliferative processes. We report the case of a 6 year old girl who consulted for perioral bullous lesions without other symptoms. Read More

    Development of bullous pemphigoid in a patient with psoriasis and metabolic syndrome.
    Cutis 2016 Sep;98(3):E19-E23
    Department of Dermatology and Immunodermatology, Medical University of Warsaw, Poland.
    Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that most commonly affects adults older than 60 years, whereas psoriasis vulgaris (PV) is a chronic immune-mediated disease that affects both children and adults. Bullous pemphigoid and PV may coexist with each other as well as with various other internal disorders, which may lead to early death. We report the case of a 35-year-old man with a 15-year history of PV and obesity who developed tense blisters with annular arrangement and normal-appearing perilesional skin localized mainly on the trunk, arms, and legs resembling linear IgA bullous dermatosis. Read More

    Vancomycin-induced linear IgA bullous dermatosis: associations.
    Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
    Coimbra University Hospital, Coimbra.
    Unlabelled: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases. Read More

    Specificity of granular IgM deposition in folliculosebaceous units and sweat gland apparatus in direct immunofluorescence (DIF) of lupus erythematosus.
    J Am Acad Dermatol 2016 Aug 28;75(2):404-9. Epub 2016 May 28.
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:
    Background: Diagnosis of lupus erythematosus (LE) in direct immunofluorescence testing is based on the finding of positive immunofluorescence at the dermoepidermal junction (DEJ).

    Objectives: We sought to evaluate the sensitivity of IgM deposition at the DEJ and adnexal structures in the diagnosis of lupus erythematosus.

    Methods: We conducted a retrospective study of 100 previously diagnosed cases of lupus erythematosus and 158 cases of other immune-mediated dermatosis. Read More

    Immune-mediated reactions to vancomycin: A systematic case review and analysis.
    Ann Allergy Asthma Immunol 2016 Jun 4;116(6):544-53. Epub 2016 May 4.
    Harvard Medical School, Boston, Massachusetts; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts; Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts.
    Background: Vancomycin is a broad-spectrum antibiotic whose use may be limited by adverse drug reactions (ADRs). Although vancomycin toxic effects are known, there are limited data on vancomycin hypersensitivity reactions (HSRs).

    Objective: To understand the most commonly reported vancomycin HSRs through systematic case review. Read More

    Pemphigus vulgaris-associated interstitial lung disease.
    Dermatol Ther 2016 Jul 11;29(4):228-32. Epub 2016 Mar 11.
    Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.
    Autoimmune bullous diseases (AIBDs)-associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV-associated ILD has rarely been reported in English literature. Read More

    A subepidermal blistering disorder.
    S Afr Med J 2016 Feb 22;106(3):263. Epub 2016 Feb 22.
    Department of Internal Medicine, Addington Hospital, Durban, South Africa.
    A young woman presented with generalised tense blisters. There had been no previous drug exposure and she had no clinical signs of autoimmune disease or evidence of sepsis. Given the abrupt onset and clinical scenario, a skin punch biopsy was performed and a tentative diagnosis of linear IgA bullous dermatosis (LABD) was made. Read More

    Bullous diseases: Kids are not just little people.
    Clin Dermatol 2015 Nov-Dec;33(6):644-56. Epub 2015 Sep 14.
    Departments of Dermatology & Pediatrics, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, 12th Floor, New York, NY, 10032, USA. Electronic address:
    Bullous diseases may be rare; however, this does not preclude the clinician from being familiar with their manifestations and treatment. After ruling out infection, genetically inherited blistering diseases are more likely to be the cause of blistering or erosions in the neonatal period, whereas immunobullous diseases are more common in adults. Published literature on immunobullous disorders reflects information gleaned from case reports and open-label case series; prospective studies and evidence-based treatments are limited. Read More

    Linear IgA Bullous Dermatosis: A Rare Clinicopathologic Entity with an Unusual Presentation.
    J Clin Aesthet Dermatol 2015 Oct;8(10):43-6
    University of Nevada School of Medicine, Reno and Las Vegas, Nevada; Associated Pathologists, Chartered, Las Vegas, Nevada.
    Linear immunoglobulin A bullous dermatosis is a rare autoimmune mucocutaneous disorder caused by immunoglobulin A autoantibodies produced against several different antigens in the basement membrane zone. Clinically, it is characterized by tense vesicles or bullae, which on histopathological exam demonstrate subepidermal blister with a predominantly neutrophilic infiltrate. A smooth, linear pattern of immunoglobulin A deposition in the basement membrane zone on direct immunofluorescence is considered the gold standard for establishing a diagnosis. Read More

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