493,649 results match your criteria Linear IgA Dermatosis


Pediatric Nurses' Knowledge of and Self-Efficacy in Breastfeeding Counseling.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Public Health, Department of Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Objective:  Sound breastfeeding (BF) knowledge among health professionals is vital for proper institutional support of BF mothers. This study aims to measure both BF knowledge and self-efficacy (SE) of pediatric nurses in supporting BF and to determine their associated factors.

Study Design:  A cross-sectional study was conducted in Mansoura University Children's Hospital and Mansoura New General Hospital during the period from January to March 2017. Read More

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December 2018
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Anomalous Bodily Maps of Emotions in Schizophrenia.

Schizophr Bull 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, Vanderbilt University, Nashville, TN.

Objective: Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feature of schizophrenia (SZ) is characterized by the presence of bodily self-disturbances and social-emotional deficits, we hypothesized that embodiment of emotion would be disrupted in SZ. Read More

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December 2018
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Disentangling the effects of disturbance, climate and tree age on xylem hydraulic conductivity of Betula pendula.

Ann Bot 2018 Dec 14. Epub 2018 Dec 14.

Department of Physical Geography and Geoecology, Faculty of Science, Charles University, Prague, Czech Republic.

Background And Aims: The increasing frequency of disturbances in temperate forests is responsible for the greater numbers of trees with mechanically damaged cambial zones. Adjustment of wood anatomical structure to balance between safe and efficient water conductivity is one mechanism trees employ to cope with mechanical damage. The relative role of disturbances, tree age and climate in shaping xylem conduits and affecting xylem hydraulic conductivity remains unknown. Read More

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December 2018

Self-faceting of emulsion droplets as a route to solid icosahedra and other polyhedra.

J Colloid Interface Sci 2018 Dec 2;538:541-545. Epub 2018 Dec 2.

Department of Physics, Bar-Ilan University, Ramat-Gan 5290002, Israel; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel. Electronic address:

Hypothesis: Temperature-controlled self-faceting of liquid droplets has been recently discovered in surfactant-stabilized alkane-in-water emulsions. We hypothesize that similar self-faceting may occur in emulsion droplets of UV-polymerizable linear hydrocarbons. We further hypothesize that the faceted droplet shapes can be fixed by UV-initiated polymerization, thus providing a new route towards the production of solid polyhedra. Read More

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December 2018

Biosensing methods for determination of creatinine: A review.

Biosens Bioelectron 2018 Nov 25;126:707-724. Epub 2018 Nov 25.

Department of Zoology, M.D. University, Rohtak 124001, India.

Creatinine is a metabolic product of creatine phosphate in muscles, which provides energy to muscle tissues. Creatinine has been considered as indicator of renal function specifically after dialysis, thyroid malfunction and muscle damage. The normal level of creatinine in the serum and its excretion through urine in apparently healthy individuals is 45-140 μM and 0. Read More

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November 2018

Sedimentary archive of Polycyclic Aromatic Hydrocarbons and perylene sources in the northern part of Taihu Lake, China.

Environ Pollut 2018 Dec 5;246:198-206. Epub 2018 Dec 5.

Institute of Applied Geosciences, Technical University of Darmstadt, Schnittspahnstrasse 9, 64287, Darmstadt, Germany; IWW Water Centre, Moritzstrasse 26, 45476, Mülheim an der Ruhr, Germany. Electronic address:

In the present work, we analyzed the concentration patterns of 20 Polycyclic Aromatic Hydrocarbons (PAHs) in 25 surface sediments and 11 sediment cores from the northern part of Taihu Lake, China. Three of the cores were dated based on Cs activity for the deposition age of the sediment. The spatial distributions of the PAH concentrations show that the inflow rivers into Zhushan Bay and Meiliang Bay were the main pathway for PAHs and sediment input to the northern part of the lake. Read More

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December 2018

4-Fluoramphetamine in the Netherlands: Text-mining and sentiment analysis of internet forums.

Int J Drug Policy 2018 Dec 11;64:34-39. Epub 2018 Dec 11.

Trimbos Institute, The Netherlands Institute of Mental Health and Addiction, Da Costakade 45, 3521VS, Utrecht, the Netherlands.

Background: Users of new psychoactive substances including 4-fluoroamphetamine (4-FA/4-FMP) frequently share their experiences or opinions in online drug forums. We have tested the potential of computerised analysis of drug users' forum posts for monitoring and early detection of trends. Specifically, we tested whether changes in the volume of 4-FA related posts and sentiments expressed in those posts can be observed around the time 4-FA was increasingly reported by Dutch drug monitoring sources (2012-2017). Read More

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December 2018

Identification of B cell epitopes enhanced by protein unfolding and aggregation.

Mol Immunol 2018 Dec 11;105:181-189. Epub 2018 Dec 11.

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, UK. Electronic address:

Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is currently little information regarding how aggregates interact with B-cell receptors or cognate antibodies at the protein sequence level, or whether non-native, aggregate-induced epitopes predominate in these interactions. Using an antibody fragment (single chain antibody variable fragment; scFv) that forms aggregates readily at low temperature, anti-scFv IgG antibody responses were generated by intraperitoneal injection of BALB/c strain mice with monomer or aggregate preparations. Read More

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December 2018
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CircRNAs and cancer: biomarkers and master regulators.

Semin Cancer Biol 2018 Dec 11. Epub 2018 Dec 11.

Molecular Oncology group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:

Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. Read More

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December 2018
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Impact of strain and duration of thermal stress on carcass yield, metabolic hormones, immunological indices and the expression of HSP90 and Myogenin genes in broilers.

Res Vet Sci 2018 Nov 30;122:193-199. Epub 2018 Nov 30.

Department of Animal Wealth Development, Zagazig University, Sharkia, Egypt. Electronic address:

The aim was to elucidate the effects of strain and the duration of thermal stress (36 °C) on the carcass yield, metabolic hormones, immunological parameters and the relative expression of liver heat shock protein 90 (HSP90) and Myogenin genes. Two hundred and seventy day-old chicks (135 of each breed; Ross 308 and Cobb 500) were used in this trial. The birds were divided into 3 equal groups (CON: thermoneutral condition; S and S groups were subjected to 4 and 6 h of daily thermal stress, respectively. Read More

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November 2018

Assessment of riparian vegetation characteristics in Mediterranean headwaters regulated by check dams using multivariate statistical techniques.

Sci Total Environ 2018 Dec 5;657:597-607. Epub 2018 Dec 5.

Department "Agraria", University "Mediterranea" of Reggio Calabria, Località Feo di Vito - I, 89122 Reggio Calabria, Italy.

In mountainous torrents of the Mediterranean environment the riparian vegetation is strongly influenced by the presence of engineering control works, since these structures bring heavy modifications in channel geometry, hydraulic regime and bed sediment size. Previous investigations have shown high linear correlations between physical (section shape, profile slope, specific discharge, surface and subsurface size of the channel bed) and vegetation (development, structure and biodiversity) indicators in headwater channels with check dams of Calabrian (Southern Italy) torrents. Based on these findings, this study applies multivariate statistical techniques (Principal Component Analysis and Partial Least Square Regression) to identify in the same study headwaters new synthetic explanatory variables, representative of the different transects (upstream, downstream or intermediate, compared to the check dam location) and develop predictive models of riparian vegetation characteristics. Read More

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December 2018

A novel catalase mimicking nanocomposite of Mn(II)-poly-L-histidine-carboxylated multi walled carbon nanotubes and the application to hydrogen peroxide sensing.

Anal Biochem 2018 Dec 11. Epub 2018 Dec 11.

The Key Laboratory of Bioactive Materials Ministry of Education, College of Life Science, Nankai University, Weijin Road No.94, Tianjin, 300071, China. Electronic address:

In this work, a novel enzyme-mimicking nanocomposite of Mn(II)-poly-L-histidine (PLH) functionalized carboxylated multi walled carbon nanotubes (CMWCNTs) was designed and synthesized. Based on the catalase-like activity of the nanocomposite, a non-enzymatic hydrogen peroxide (H2O2) biosensor was then established and explored for H2O2 electrochemical detection. The nanocomposite was characterized by Fourier transform infrared spectra, Raman spectroscopy, and transmission electron microscopy. Read More

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December 2018
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Random subspace-based ensemble modeling for near-infrared spectral diagnosis of colorectal cancer.

Anal Biochem 2018 Dec 11. Epub 2018 Dec 11.

Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan, 644000, China. Electronic address:

The feasibility of using near-infrared (NIR) spectroscopy coupled with classifier ensemble for improving the diagnosis of colorectal cancer was explored. A total of 157 NIR spectra from the patients were recorded and partitioned into the training set and the test set. Four algorithms, i. Read More

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December 2018

Impact of hospital hospitality house programs on quality of life and mood of patients and caregivers after hematopoietic stem cell transplant.

Hematol Oncol Stem Cell Ther 2018 Dec 9. Epub 2018 Dec 9.

Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Objective/background: The quality of life (QOL) of hematopoietic stem cell transplant (HSCT) patients and their caregivers decreases during the first 8 days after HSCT.

Methods: This prospective pilot study collected preliminary data on the impact of posttransplant living arrangements (hospital hospitality house [HHH] vs. hotel, apartment, or house ["hotel"]) and other factors on the QOL of HSCT patients and their caregivers. Read More

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December 2018
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The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5862-5867

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG).

Methods: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories. Read More

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December 2018

Nutritional risk index as a predictor of mortality in acutely decompensated heart failure.

PLoS One 2018 14;13(12):e0209088. Epub 2018 Dec 14.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Background: We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF).

Methods: Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41. Read More

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December 2018
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Postural Control Deficits After Repetitive Soccer Heading.

Clin J Sport Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.

Objective: To determine the acute effects of repetitive soccer heading on postural control.

Design: Prospective study; participants were divided into 2 groups: a soccer heading group and a control group.

Setting: Biomechanics laboratory. Read More

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December 2018

Nocturnal ventricular repolarization lability predicts cardiovascular mortality in the Sleep Heart Health Study.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Institut für Biomedizinische Technik, TU Dresden.

Background-The objective of this study was to quantify repolarization lability and its association with sex, sleep stage and cardiovascular mortality. Methods-We analyzed polysomnographic recordings of 2,263 participants enrolled in the Sleep heart health study (SHHS-2). Beat-to-beat QT interval variability (QTV) was quantified for consecutive epochs of 5 minutes according to the dominant sleep stage (AWAKE, NREM2, NREM3, REM). Read More

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December 2018

Relations between spatial skills and math performance in elementary school children: A longitudinal investigation.

Dev Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, Florida State University.

Previous research has demonstrated a link between spatial and math skills. However, little research has examined this relation longitudinally. The present study examines the development of and reciprocal relations between spatial and math skills in elementary school students. Read More

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December 2018

Theoretical Insights on Nonlinear Response Theory of Fluorescence Spectroscopy in Liquids.

J Chem Theory Comput 2018 Dec 14. Epub 2018 Dec 14.

Correlations between the nonequilibrium solvation dynamics upon the photon excitation of the chromophore and system's equilibrium fluctuations are deeply studied. As linear response of the solvent has been linked with Gaussian statistics of the energy fluctuations in literatures, we specifically explore the cases beyond the regime of the linear response theory due to deviation from Gaussian fluctuations. As a continuation of our previous work, an analytical formalism is presented to project the energy shift with various order moments, where the non-Gaussian statistics arise from the overlap of the energy basins on the perturbed potential energy surface. Read More

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December 2018

[The synchronous detection of serological markers of main herpes viral human infections].

Klin Lab Diagn 2018 ;63(1):35-40

The closed corporation "ECOlab", Elektrogorsk, Moscow oblast, Russia.

The new original national set of reagents "Line-Blot human herpesvirus-profle" was developed to detect antibodies (IgG - set 1 and IgM - set 2) to main agents of herpesvirus infections (HSV-1, HSV-2, VZV, EBV, CMV) in the format of linear immunoblotting. The preliminary clinical trials were implemented using 319 samples of blood serum: HIV-infected patients (n=128), pregnant women (n=86) and persons undergoing treatment or diagnostic examination (n=105). In the case of every infection agent analyzes were implemented using enzyme-linked immunosorbent assay and linear immunoblotting with new set and its analogues of German manufacturer. Read More

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January 2018

Sparsity-based photoacoustic image reconstruction with a linear array transducer and direct measurement of the forward model.

J Biomed Opt 2018 Dec;24(3):1-9

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.

Photoacoustic (PA) imaging is an emerging imaging technique for many clinical applications. One of the challenges posed by clinical translation is that imaging systems often rely on a finite-aperture transducer rather than a full tomography system. This results in imaging artifacts arising from an underdetermined reconstruction of the initial pressure distribution (IPD). Read More

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December 2018

Estimated Total Albumin in Fresh Urine Samples Based on Correlation Between the Roche Immunoturbidimetric and an In-House HPLC Method.

Clin Lab 2018 Oct;64(11)

Background: Many studies have reported higher values of urinary albumin measured by high performance liquid chromatography (HPLC) in comparison with immunochemical methods. The aims of our study were the implementation of the HPLC method for albuminuria, testing the hypothesis about coeluting proteins, comparison of albuminuria assessed by HPLC and immunoturbidimetric (IT) methods in diabetic and non-diabetic patient samples. Methods: We compared albuminuria assessed by HPLC with albuminuria assessed by the IT method in fresh urine samples of 636 diabetics and 456 non-diabetics. Read More

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October 2018

Heterogeneity of Treatment Effects of Long-Acting Injectable Antipsychotic Medications.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Department of Psychiatry and Health Behaviors, Augusta University Health, Augusta, Georgia, USA.

Objective: To investigate subgroup responses to long-acting injectable (LAI) medications haloperidol decanoate (HD) and paliperidone palmitate (PP) in a randomized controlled trial that found no difference between the treatments on the primary outcome of efficacy failure.

Methods: A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) enrolled 311 participants from March 2011 to July 2013 meeting DSM-IV-TR criteria for diagnoses of schizophrenia or schizoaffective disorder at risk of relapse due to medication nonadherence or substance abuse. Participants were randomly assigned to double-blinded treatment with HD or PP and followed for up to 2 years. Read More

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November 2018

Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality?

J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.

Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA.

Background: According to prevailing models and classical reports, abrupt responses to antidepressant medication are not true drug responses but rather transient placebo effects. By contrast, recent reports suggest that early sudden improvements have a lasting effect and appear in most patients receiving medication. Clinical guidelines influenced by these contradictory findings are mixed and confusing. Read More

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December 2018

Investigations into the Performance of Travelling Wave-Enabled Conventional and Cyclic Ion Mobility Systems to Characterise Protomers of Fluoroquinolone Antibiotic Residues.

Rapid Commun Mass Spectrom 2018 Dec 14. Epub 2018 Dec 14.

Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, SK9 4AX, UK.

Fluoroquinolones (FLQs) are a class of antimicrobial agents which have been administered to livestock for infection prevention/control and growth promotion. In this work blank porcine muscle extract (fortified with FLQs) has been screened for the FLQ protomer species (resulting from different sites of protonation) using the cumulative specificity of Ultra High Performance Liquid Chromatography coupled with Ion Mobility - Mass Spectrometry (UHPLC-IM-MS) and collision induced dissociation (CID). Collision cross sections (CCSs) and product ion spectra have been generated for the protomeric species with ΔCCS values between protomers ranging between 10-15 Å . Read More

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December 2018

Ambulatory Care Sensitive Admissions in Individuals With Autism Spectrum Disorder, Intellectual Disability, and Population Controls.

Autism Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.

Ambulatory care sensitive (ACS) admissions are those for which effective primary care can prevent the need for emergency department (ED) visits and inpatient hospitalizations, and are an indicator of primary care access. Individuals with autism spectrum disorder (ASD) and/or intellectual disability (ID) may be at higher risk for ACS admissions than individuals in the general population due to difficulty accessing primary care. The objective of this study was to compare the incidence of ACS admissions among four cohorts of individuals aged 2-24 years: ASD without co-occurring ID (ASD-only), ASD with co-occurring ID (ASD + ID), ID without ASD (ID-only), and population controls (PC). Read More

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December 2018

A Mechanically Robust, Stiff, and Tough Hyperbranched Supramolecular Polymer Hydrogel.

Macromol Rapid Commun 2018 Dec 14:e1800819. Epub 2018 Dec 14.

School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China.

In this study, a simple yet versatile method is introduced to prepare a hyperbranched supramolecular polymer hydrogel by utilizing Type II photoinitiated self-condensing vinyl polymerization of N-acryloyl glycinamide, which can serve not only as an inimer providing branching sites, but also as a hydrogen-bonding cross-linker. The hyperbranched poly(N-acryloyl glycinamide) (HB-PNAGA) hydrogels demonstrate excellent mechanical performances with a tensile strength of 0.793-2. Read More

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December 2018
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Helping Her Heal: Randomized Clinical Trial to Enhance Dyadic Outcomes in Couples.

Psychooncology 2018 Dec 13. Epub 2018 Dec 13.

University of Washington, School of Nursing, Seattle, WA.

Objective: To test the short-term efficacy of a brief, fully manualized marital communication and interpersonal support intervention for couples facing recently diagnosed breast cancer.

Methods: A total of 322 women diagnosed within 6 months with Stage 0-III breast cancer and their 322 spouse caregivers were enrolled. Spouses in the experimental group received five, 30 to 60-minute intervention sessions at 2-week intervals by Masters prepared patient educators; controls received the booklet, "What's Happening to the Woman I Love?" Outcomes were assessed at 3, 6 and 9 months using Linear Mixed Models within an intent to treat analysis. Read More

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December 2018

Longitudinal change in the cerebroplacental ratio and the risk of stillbirth.

Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK Cranmer Terrace, London, SW17 0RE.

Objectives: To investigate whether the longitudinal Doppler changes in small-for-gestational age (SGA) fetuses improves the prediction of those at risk of intrauterine fetal death (IUFD).

Methods: A longitudinal study using two cohorts of singleton pregnancies (SGA and appropriate for gestational age [AGA]). The inclusion criteria for the SGA cohort were singleton pregnancies at 20 weeks' gestation or beyond and diagnosed with SGA. Read More

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December 2018

Effects of dietary ramie powder at various levels on growth performance, antioxidative capacity and fatty acid profile of finishing pigs.

J Anim Physiol Anim Nutr (Berl) 2018 Dec 13. Epub 2018 Dec 13.

Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, China.

This study was conducted to evaluate the effects of ramie (Boehmeria nivea, previously known as a fibre crop and also called "China grass") included in diets on growth performance, antioxidative capacity and muscular fatty acid profile of finishing pigs. A total of 180 Xiangcun Black pigs (initial body weight =70.71 ± 1. Read More

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December 2018

DiTe2: Calculating the diffusion tensor for flexible molecules.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Sciences, University of Padua, Padova 35131, Italy.

We report on an extended hydrodynamic modeling of the friction tensorial properties of flexible molecules including all types of natural, Z-Matrix like, internal coordinates. We implement the new methodology by extending and updating the software DiTe [Barone et al. J. Read More

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December 2018

Determination of Olanzapine for Therapeutic Drug Monitoring in Schizophrenia Patients by LC/MS Method.

Biomed Chromatogr 2018 Dec 13:e4468. Epub 2018 Dec 13.

Department of Psychiatry, İzmir Katip Çelebi University, Ataturk Training and Research Hospital, İzmir, Turkey.

Olanzapine is an atypical antipsychotic drug from thienobenzodiazepine family which displays efficacy in patients with schizophrenia and related psychoses. A novel LC/MS method was developed and validated for determination of olanzapine in schizophrenia patients plasma. A liquid-liquid extraction procedure carried out by using 5 mL diethyl ether-diisopropyl ether mixture (1:1, v/v). Read More

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December 2018

Drawing inferences for High-dimensional Linear Models: A Selection-assisted Partial Regression and Smoothing Approach.

Biometrics 2018 Dec 14. Epub 2018 Dec 14.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Drawing inferences for high-dimensional models is challenging as regular asymptotic theories are not applicable. This paper proposes a new framework of simultaneous estimation and inferences for high-dimensional linear models. By smoothing over partial regression estimates based on a given variable selection scheme, we reduce the problem to a low-dimensional least squares estimation. Read More

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December 2018

Geographical adaptation prevails over species-specific determinism in trees' vulnerability to climate change at Mediterranean rear-edge forests.

Glob Chang Biol 2018 Dec 13. Epub 2018 Dec 13.

Ecoclimatology, Department of Ecology and Ecosystem Management, Technische Universität München, Freising, Germany.

Climate change may reduce forest growth and increase forest mortality, which is connected to high carbon costs through reductions in gross primary production and net ecosystem exchange. Yet the spatiotemporal patterns of vulnerability to both short-term extreme events as well as gradual environmental changes are quite uncertain across the species' limits of tolerance to dryness. Such information is fundamental for defining ecologically relevant upper limits of species tolerance to drought and hence, to predict the risk of increased forest mortality and shifts in species composition. Read More

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December 2018

Development of a class prediction model to discriminate pancreatic ductal adenocarcinoma from pancreatic neuroendocrine tumor by MALDI mass spectrometry imaging.

Proteomics Clin Appl 2018 Dec 13:e1800046. Epub 2018 Dec 13.

R. Casadonte, J. Kriegsmann, Proteopath GmbH, Trier, Germany.

Purpose: To define proteomic differences between pancreatic ductal adenocarcinoma (pDAC) and pancreatic neuroendocrine tumor (pNET) by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI).

Experimental Design: 93 pDAC and 126 pNET individual tissues were assembled in tissue microarrays and analyzed by MALDI MSI. The cohort was separated in a training (52 pDAC and 83 pNET) and validation set (41 pDAC and 43 pNET). Read More

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December 2018

Helicenes built from silacyclopentadienes via ring-by-ring knitting of the helical framework.

Angew Chem Int Ed Engl 2018 Dec 13. Epub 2018 Dec 13.

CZECH REPUBLIC.

Despite the apparent diversity of the protocols developed for the synthesis of helicenes, they essentially follow the same strategy: the closure of one, or several, internal rings in a key step. Herein, we report the synthesis of a new family of the heterohelicenes consisting of fused silacyclopentadiene rings formed via a facile and novel process. The treatment of oligo(alkynilydenesilylene) precursors of type H2C=CH-(SiMe2-C≡C)n-R (n = 3 - 7), bearing a vinyl group on the terminal silicon atom, with 9-borabicyclononane leads first to 1,2-hydroboration of the terminal double bond which then continues with a cascade of intramolecular 1,1-carboboration reactions accompanied with the closure of a new silole ring after each step affording the target silahelicenes with, currently, up to seven condensed silole rings and with excellent yields. Read More

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December 2018

Seeing the Unseen: Evaluating Testicular Vascularity in Neonates by Using the Superb Microvascular Imaging Ultrasound Technique.

J Ultrasound Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, Istanbul Medeniyet University, Faculty of Medicine, Istanbul, Turkey.

Objectives: To evaluate testicular vascularity in neonates by using the novel Superb Microvascular Imaging (SMI; Toshiba Medical Systems Corporation, Tokyo, Japan) ultrasound (US) technique and to compare this technique to conventional Doppler US techniques.

Methods: A total of 140 healthy neonates between 2 and 60 days old who were admitted for routine screening were included in the study. However, in 9 cases, the Doppler study could not be completed. Read More

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December 2018

Behavioral and endocrine correlates of dominance in captive female Jackson's hartebeest (Alcelaphus buselaphus).

Zoo Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biology, Georgia Southern University, Statesboro, Georgia.

For species that form dominance hierarchies, such as group-living ungulates, aggressive interactions can pose a challenge to successful captive management. For example, Jackson's hartebeest (Alcelaphus buselaphus), a rare antelope of east Africa, can be difficult to maintain in captivity because aggression within female dominance hierarchies can lead to injury and death. We quantified behavioral and endocrine correlates of dominance in a captive herd of ten female hartebeest with the goal of understanding how to minimize dangerous interactions. Read More

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December 2018

Linear Viscoelastic Properties of Selected Polysaccharide Gums as Function of Concentration, pH, and Temperature.

J Food Sci 2018 Dec 13. Epub 2018 Dec 13.

Dept. of Biomolecular Sciences, School of Pharmacy, Univ. of Urbino, Piazza del Rinascimento, 6, 61029, Urbino (PU), Italy.

Hydrocolloids have been intensively investigated due to their ability to modify the rheology of the system where they are employed. They find application as thickening and gelling agents in many food, cosmetic, and pharmaceutical preparations, due to their biocompatibility and biodegradability. The present study aims to provide an exhaustive and comprehensive viscoelastic characterization of a series of hydrocolloid formulations, as function of concentration, pH, and temperature. Read More

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December 2018

Macrocyclization enhances affinity of chemokine-binding peptoids.

Biopolymers 2018 Dec 13:e23244. Epub 2018 Dec 13.

Clemens-Schöpf-Institute of Organic Chemistry and Biochemistry, TU Darmstadt, Darmstadt, Germany.

Peptoids that bind to protein targets can be selected from one-bead-one-compound libraries. Macrocyclization has been often used to increase conformational rigidity and binding affinity in both peptides and peptoids. Here we describe a combined strategy to label and cyclize hexameric peptoid sequences previously identified in a screen against the inflammatory chemokine interleukin-8/CXCL8 that is involved in a number of inflammatory diseases. Read More

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December 2018

DENTAL SIGNATURES FOR EXUDATIVORY IN LIVING PRIMATES, WITH COMPARISONS TO OTHER GOUGING MAMMALS.

Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.

Dept. of Anthropology, University of Toronto Scarborough, Toronto, CANADA.

Exudativory, the consumption of gums, is an obligate or a facultative dietary niche for some primates and marsupials. Exudativory has been cited as a dietary niche that may have been present in early primates, so finding a dental signature for exudativory is highly desirable. The present study combines exudativorous lorisoids (galagos and lorises) into one sample to compare to closely related, non-exudativorous lorisoids to search for a consistent dental signature of exudativory. Read More

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December 2018

Direct comparison between surface imaging and orthogonal radiographic imaging for SRS localization in phantom.

J Appl Clin Med Phys 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, Cone Health Cancer Center, Greensboro, North Carolina, 27403, USA.

Purpose: Surface imaging (SI) offers a nonionizing, near real time alternative to radiographic imaging for intrafraction radiosurgery localization. In this work, we systematically compared a commercial SI system vs a commercial room mounted x-ray localization system in phantom.

Methods: An anthropomorphic head phantom with fiducial markers was imaged with linear accelerator on-board x-ray imaging, SI, and room mounted x-ray imaging (RM) at ±45° and ±90° couch angles for three different head tilts and six different isocenters (72 total positions). Read More

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December 2018

Health-related quality of life changes following renal transplantation in children.

Pediatr Transplant 2018 Dec 12:e13333. Epub 2018 Dec 12.

Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.

Background: Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL.

Methods: We performed a retrospective study using the PedsQL3. Read More

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December 2018

Integrated internal standards: A sample prep-free method for better precision in microchip CE.

Electrophoresis 2018 Dec 13. Epub 2018 Dec 13.

BIOS-Lab on a Chip Group, MESA+ Institute of Nanotechnology, TechMed Centre and Max Planck Center for Complex Fluid Dynamics, University of Twente, Enschede, Overijssel, The Netherlands.

Point-of-care systems based on microchip capillary electrophoresis require single-use, disposable microchips pre-filled with all necessary solutions so an untrained operator only needs to apply the sample and perform the analysis. While microchip fabrication can be (and has been) standardized, some manufacturing differences between microchips are unavoidable. To improve analyte precision without increasing device costs or introducing additional error sources, we recently proposed the use of integrated internal standards (ISTDs): ions added to the BGE in small concentrations which form system peaks in the electropherogram that can be used as a measurement reference. Read More

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December 2018

Generalized Model of the Linear Theory of Electromigration and its Application to Electrokinetic Chromatography: Theory and Software PeakMaster 6 - Next Generation.

Electrophoresis 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Science, Department of Physical and Macromolecular Chemistry, Charles University in Prague, Prague, Czech Republic.

The linear theory of electromigration, including the first-order nonlinear approximation, is generalized to systems with any equilibria fast enough to be considered instantaneous in comparison with the time-scale of peak movement. For example, this theory is practically applied in the electrokinetic chromatography (EKC) mode of the capillary zone electrophoresis. The model enables the calculation of positions and shapes of analyte and system peaks without restricting the number of selectors, the complexation stoichiometry, or simultaneous acid-base equilibria. Read More

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December 2018

Reduced fear-of-self is associated with improvement in concerns related to repugnant obsessions in obsessive-compulsive disorder.

Br J Clin Psychol 2018 Dec 12. Epub 2018 Dec 12.

Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Quebec, Canada.

Objective: The potential causal and maintaining role of vulnerable self-themes and beliefs about the self in obsessive-compulsive disorder (OCD) have received increasing attention from cognitive-behavioural theorists. This interest was translated into the development of a self-report measurement of the feared self (the fear of who one might be or become), a construct theoretically and empirically pertinent to unwanted thoughts and impulses in OCD (i.e. Read More

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December 2018

A quantitative LC-MS/MS method for determination of a small molecule agonist of EphA2 in mouse plasma and brain tissue.

Biomed Chromatogr 2018 Dec 12:e4461. Epub 2018 Dec 12.

Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Compound 27 [1, 12-bis(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)dodecane-1,12-dione ] is a novel small molecule agonist of EphA2 receptor Tyrosine Kinase. It showed much improved activity for the activation of EphA2 receptor compared to the parental compound Doxazosin. To support further pharmacological and toxicological studies of the compound, a method using liquid chromatography and electrospray ionization tandem mass spectrometry (LC- MS/MS) has been developed for the quantification of this compound. Read More

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December 2018

Raynaud's phenomenon and anti-nuclear antibody are associated with pulmonary function decline in patients with dermatomyositis and polymyositis.

Int J Rheum Dis 2018 Dec 11. Epub 2018 Dec 11.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Objectives: To identify factors associated with deterioration of pulmonary function with disproportional decline in diffusing capacity for carbon monoxide (DLCO) relative to forced vital capacity (FVC) in patients with dermatomyositis (DM) and polymyositis (PM).

Methods: This retrospective cohort study included patients with DM and PM, in whom serial pulmonary function tests were available. Changes in FVC and DLCO over time were estimated using a linear mixed-effects model. Read More

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December 2018

Analysis of condensed tannins in Populus spp. using reversed phase UPLC-PDA-(-)esi-MS following thiolytic depolymerisation.

Phytochem Anal 2018 Dec 11. Epub 2018 Dec 11.

Department of Entomology, University of Wisconsin-Madison, Madison, WI, USA.

Introduction: Condensed tannins (CTs) are proanthocyanidin heteropolymers that are widely distributed among plants. Their biochemical properties are determined by molecular structure (e.g. Read More

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December 2018