32,844 results match your criteria Life sciences[Journal]


Effect of waterpipe tobacco smoke exposure during lactation on learning and memory of offspring rats: Role of oxidative stress.

Life Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Aims: The prevalence of waterpipe tobacco smoking is increasing among breastfeeding women. Herein, the effect of maternal waterpipe tobacco smoke (WTS) exposure during lactation on learning and memory of adult offspring rats was examined.

Main Methods: Lactating rats received either fresh air or mainstream WTS (1 h twice daily) from day 4 to day 21. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.049DOI Listing

Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.

Life Sci 2019 Apr 19. Epub 2019 Apr 19.

College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address:

Aims: To investigate the antitumor effect of 7-O-geranylquercetin (GQ) combining with survivin siRNA (siSuvi) or IL-10 siRNA (siIL-10) to breast cancer.

Main Methods: Xenograft tumor model was established by subcutaneously inoculating human breast cancer MCF-7 cells in BALB/c nude mice. Transfection efficiency of siRNA mediated by cationic liposome CDO14 in MCF-7 cells and tumor bearing mice was measured by flow cytometer and living imaging sysytem, respectively. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.047DOI Listing

ERK activation by zeranol has neuroprotective effect in cerebral ischemia reperfusion.

Life Sci 2019 Apr 18. Epub 2019 Apr 18.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Aims: Incidence of stroke increases in postmenopausal women with dangerous consequences. In this study we used zeranol to protect ovariectomized (OVX) rats against cerebral I/R damage and our target is to identify the mechanism of its protection, in addition to investigating whether this mechanism inhibits inflammation (by preventing glial cell activation) and apoptosis.

Main Methods: First 18 ovariectomized rats were allocated into 3 groups: I/R group, zeranol+ I/R group and U0126, MEK1/2 inhibitor + zeranol+ I/R group. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.035DOI Listing

What is the role of peptide fragments of collagen I and IV in health and disease?

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the extracellular matrix (ECM), then problems arise. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.042DOI Listing
April 2019
2 Reads

NHCl treatment prevents doxorubicin-induced myocardial dysfunction in vivo.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

Aims: Improvements in cancer treatment have significantly extended the lifespan of patients. However, due to the adverse effects of cancer treatment, cancer survivors are at increased risk of cardiovascular complications. Doxorubicin is a widely used spectrum antitumor drug, but the life-threatening side-effect of cardiotoxicity limits its clinical application. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.044DOI Listing

Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Aims And Methods: Acute myocardial infarction (AMI) is a common cardiovascular disease with high mortality. Astragaloside IV (AS-IV) was reported to have cardioprotective effect after AMI. We hypothesize that the cardioprotective role of AS-IV is exerted by enhancing angiogenesis via regulating PTEN/PI3K/Akt signaling pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.040DOI Listing
April 2019
2 Reads

Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Hematology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Department of General Practice, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Aims: Alantolactone (ALT) is active component of natural product Inula helenium with a lot of pharmacological effects, including anti-tumor effect. The present work aimed to explore the antitumor effect of ALT in B cell acute lymphoblastic leukemia (B-ALL).

Main Methods: B-ALL cells were treated with various concentrations of ALT, and then trypan blue assay, Annexin V/PI staining assay, PI staining assay, western blot analysis were employed to measure the effect of ALT on viability, apoptosis and cell cycle in B-ALL cells. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.034DOI Listing
April 2019
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miR-27a promotes endothelial-mesenchymal transition in hypoxia-induced pulmonary arterial hypertension by suppressing BMP signaling.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha, Hunan 410078, China. Electronic address:

Aim: Growing evidence suggests that endothelial-mesenchymal transition (EndMT) play key roles in pulmonary arterial remodeling during pulmonary arterial hypertension (PAH), but the underlying mechanisms have yet to be fully understood. miR-27a has been shown to promote proliferation of pulmonary arterial cells during PAH, but its role in EndMT remains unexplored. This study was designed to investigate the role and underlying mechanism of miR-27a in EndMT during PAH. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.038DOI Listing

Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Aims: Increasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and verified the dynamic change of miR-155 level in acute rejection (AR) using a rat renal transplantation model. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.043DOI Listing

(-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Dentistry, University of Toronto, Canada; Deparment of Physiology, University of Toronto, Canada.

Neuropathic orofacial pain conditions represent a challenge to diagnose and treat. Natural substances are promising therapeutic options for the control of pain.

Aims: This study aimed to examine whether (-)-α-bisabolol (BISA), a natural terpene, can attenuate nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.032DOI Listing
April 2019
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The maintenance of an oral epithelial barrier.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, China. Electronic address:

Oral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed that different factors including microorganism, saliva, proteins and immune components have been considered to play a critical role in the disruption of oral epithelial barrier. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.029DOI Listing
April 2019
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New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

We previously showed that folate liposomes of 5FU made from Dipalmitoylphosphatidylcholine (DPPC) induced cell death in HT-29 and HeLa cells more potently than bulk 5FU. Also, a primary 5FU liposomal formulation with phosphatidyl choline (PC) exhibited higher cytotoxicity in murine colon cancer cells. In the present study, optimization of 5FU PC liposome, mechanism of cell death induction in human cancer cell lines and its safety along with other assays have been employed for targeted PC liposomes of 5FU. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.030DOI Listing

Benidipine, an anti-hypertensive drug, relaxes mouse airway smooth muscle.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Institute For Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address:

Aims: Benidipine is a dihydropyridine (DHP) derived Ca antagonist, can block triple Ca channels (L, N, and T). It has been used as an safety anti-hypertensive drug because of its long-acting relaxant effect on vascular smooth muscle (VSM). However, whether benidipine has similar pharmacological actions in airway smooth muscle (ASM) is unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193029
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http://dx.doi.org/10.1016/j.lfs.2019.04.036DOI Listing
April 2019
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NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, China. Electronic address:

Aims: NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was involved in regulating and activating the IL-23/IL-17 axis in ischaemic stroke. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.031DOI Listing

Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China.

The gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.039DOI Listing
April 2019
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Abnormality of hepatic triglyceride metabolism in Apc mice with colon cancer cachexia.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, No.5333 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. Electronic address:

Aims: Colorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of Apc mice.

Main Methods: We measured the expression of metabolic enzymes that involved fatty acid uptake, de novo lipogenesis (DNL), β-oxidation and investigated hepatic triglyceride production in the liver of wild-type and Apc mice. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.041DOI Listing

Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong 250021, China. Electronic address:

Aims: Small-for-gestational-age (SGA) fetus is an important public health issue because of its high mortality and long-term effects on health. Maternal hyperuricemia is associated with diverse adverse pregnant outcomes and neonatal disturbance. We aimed to evaluate whether maternal hyper-uric acid (HUA) is associated with the risk of SGA fetus and to explore whether it can modify the association between maternal hyper-blood pressure (HBP) and SGA fetus. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.033DOI Listing

Omega-3 fatty acids protects against chronic sleep-deprivation induced memory impairment.

Life Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Aims: The current study aims to evaluate the possible protective effect of omega-3 fatty acids on memory impairment induced by sleep-deprivation in rats.

Materials And Methods: Animals were chronically sleep deprived using the modified multiple platform model (8 h/day for 8 weeks). Omega-3 fatty acids were administered as fish oil via oral gavage at a daily dose of 100 mg omega-3 PUFA/100 g BWT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193028
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http://dx.doi.org/10.1016/j.lfs.2019.04.028DOI Listing
April 2019
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Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury.

Life Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Introduction: Ischemic stroke is one of the leading causes of death worldwide, and extensive efforts have focused on the neuroprotective strategies to minimize complications due to ischemia. This study aimed to examine neuroprotective potential of chrysin, as a natural potent antioxidative and anti-inflammatory agent in an animal model of bilateral common carotid artery occlusion and reperfusion (BCCAO/R).

Methods: Adult male Wistar rats (250-300 g) were randomly divided into 6 groups and submitted to either sham surgery or BCCAO/R after pretreatment with chrysin (10, 30 and 100 mg/kg, once daily, for 21 consecutive days) or saline containing %5 DMSO. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.027DOI Listing

Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function.

Life Sci 2019 Apr 13. Epub 2019 Apr 13.

HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America.

Aims: The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model.

Main Methods: Rats were randomized to normothermia (n = 10) or LTH (initiated at 1 min after coronary artery reperfusion, n = 10) and subjected to 30 min of coronary occlusion followed by 6 weeks of reperfusion. Hypothermia was induced by pumping cold saline over the anterior surface of the LV until the temperature cooled to <32 °C. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.026DOI Listing
April 2019
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Celastrol-type HSP90 modulators allow for potent cardioprotective effects.

Life Sci 2019 Apr 12. Epub 2019 Apr 12.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada; Department of Surgery, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Aims: Cardiac ischemic conditioning has been shown to decrease ischemic injury in experimental models and clinically. Activation of survival pathways leading to heat shock proteins (HSP) modulation is an important contributor to this effect. We have previously shown that celastrol, an HSP90 modulator, achieves cardioprotection through activation of cytoprotective HSP's and heme-oxygenase-1 (HO-1). Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.025DOI Listing
April 2019
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A potential bioactive peptide candidate for biomaterial and tissue engineering applications.

Life Sci 2019 Apr 12. Epub 2019 Apr 12.

School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamilnadu, India. Electronic address:

The surface modification of biomaterials with matrikines for tissue engineering application is one of the recent approaches to improve their biocompatibility. In an earlier study, a peptide containing 21 amino acid isolated from bovine tendon collagen was shown to promote good cell adhesion in HeLa cell, and a smaller region in the peptide was identified using bioinformatics tool to mediate cell-peptide interaction. Hence, the present study was undertaken to validate the cell adhesion property of the smaller region of the peptide and elucidate probable peptide-cell interaction pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.010DOI Listing

Protective effect of diallyl sulfide against lead-mediated oxidative damage, apoptosis and down-regulation of CYP19 gene expression in rat testes.

Life Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Anatomy and Embryology, Faculty of Medicine, Helwan University, Cairo, Egypt.

Aims: The present study aimed to investigate the potential therapeutic effect of diallyl sulfide (DAS), a natural component of garlic (Allium sativum), in the improvement of lead (Pb)-induced testicular toxicity and its underlying mechanisms.

Materials And Methods: Thirty-two male albino rats were randomly divided into control, PbAc (20 mg lead acetate/kg bwt, orally), DAS (200 mg/kg bwt, orally), and PbAc + DAS groups for 49 successive days. The investigation based on the following criteria: Paired testes and epididymides weights, epididymal sperm analysis, level of serum sex hormones (Testosterone and17β-estradiol (E2)), aromatase (CYP19) expression, Malondialdehyde (MDA), Nitric oxide (NO), Superoxide dismutase (SOD) enzyme, reduced glutathione (GSH), testicular histopathology, spermatogenesis score and apoptosis detection (Caspase-3 immunoexpression). Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.020DOI Listing
April 2019
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Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration.

Life Sci 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Aims: The study aim was to test the efficacy of a novel created hybrid nanosystem compared to other nanosystems in treatment of scopolamine induced memory impairment.

Main Methods: The fabrication and characterization of nanoformulations (microemulsion, liposomes, ethosomes, transfersomes and transethosomes) coencapsulating two cognitive enhancers; piracetam and vinpocetine delivered intranasally, in addition to a novel nanocomposite microemulsion/vesicular nanoformulation was described.

Key Findings: Formulations delivered the drugs across sheep nasal mucosa, with cumulative percentage reaching 29. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.014DOI Listing

Knockdown of Delta-like 3 restricts lipopolysaccharide-induced inflammation, migration and invasion of A2058 melanoma cells via blocking Twist1-mediated epithelial-mesenchymal transition.

Life Sci 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, The First People's Hospital of Lanzhou City, Lanzhou 730050, Gansu, China. Electronic address:

Aims: To investigate the effects and mechanisms of DLL3 in inflammation-mediated A2058 melanoma cell invasion and metastasis.

Materials And Methods: Melanoma A2058 cells was stimulated with lipopolysaccharide (LPS), with or without transfection of DLL3 siRNA, or DLL3 overexpression vector, or Twist1 siRNA. Cell migration and invasion were detected by wound healing and transwell invasion assay. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.024DOI Listing
April 2019
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miR-126-3p sensitizes glioblastoma cells to temozolomide by inactivating Wnt/β-catenin signaling via targeting SOX2.

Life Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, PR China. Electronic address:

Aims: The acquired drug resistance has been regarded as a main barrier for the effective treatment of temozolomide (TMZ) in glioblastoma (GBM). MiR-126-3p is commonly down-regulated and exerts tumor-suppressive roles in kinds of human cancers, including GBM. This study was designed to investigate the functions and mechanisms of miR-126-3p in regulating TMZ resistance in GBM. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.023DOI Listing

Parkinson's disease: Mechanisms, translational models and management strategies.

Life Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Zoology, Government College University, Lahore 54000, Pakistan.

Parkinson's disease is a progressive neurodegenerative disorder. The classical motor symptoms include resting tremors, bradykinesia, rigidity and postural instability and are accompanied by the loss of dopaminergic neurons and Lewy pathology. Diminished neurotransmitter level, oxidative stress, mitochondrial dysfunction and perturbed protein homeostasis over time worsen the disease manifestations in elderly people. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.03.057DOI Listing
April 2019
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GRP78: A cell's response to stress.

Life Sci 2019 Apr 9. Epub 2019 Apr 9.

Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt. Electronic address:

Background: Glucose-Regulated Protein 78 (GRP78) is a chaperone heat shock protein that has been intensely studied in the last two decades. GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using cellular degradation mechanisms. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.022DOI Listing
April 2019
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Periostin in chronic liver diseases: Current research and future perspectives.

Life Sci 2019 Apr 9. Epub 2019 Apr 9.

Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, China. Electronic address:

The liver is importantly metabolic and detoxifying organ in the body. When various pathogenic factors affect the liver, the normal physiological and biochemical functions are weakened, resulting in liver diseases. Liver fibrosis is a common pathological process of chronic liver disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193027
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http://dx.doi.org/10.1016/j.lfs.2019.04.021DOI Listing
April 2019
2 Reads
2.702 Impact Factor

Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets.

Sci China Life Sci 2019 Apr 9. Epub 2019 Apr 9.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

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http://dx.doi.org/10.1007/s11427-019-9522-7DOI Listing
April 2019
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Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats.

Life Sci 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Endocrine Physiology and Metabolism, Federal University of Goiás, Brazil; Neuroscience and Cardiovascular Physiology Research Center, Federal University of Goiás, Brazil. Electronic address:

Aims: Obesity is associated with innumerous comorbidities, including cardiovascular diseases, that occur by various mechanisms, including hyperactivation of the renin angiotensin system, oxidative stress and cardiovascular overload. Postnatal early overfeeding (PO) leads to metabolic imprinting that induces weight gain throughout life, and in this paper, we aimed to evaluate cardiovascular parameters and cardiac molecular changes due to obesity induced early in life by PO.

Main Methods: Male Wistar rats (120-days-old), raised in normal (NL) or small litters (SL), were submitted to cardiac assessment by transthoracic echocardiography and blood pressure evaluation. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.018DOI Listing
April 2019
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Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.

Life Sci 2019 Apr 8. Epub 2019 Apr 8.

School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address:

Aims: We previously reported that Hovenia dulcis Thunb. extract, a traditional Chinese medicine rich in dihydromyricetin (DHM), exhibited a significant hepatoprotective effect against acetaminophen (APAP)-induced liver injury. However, whether DHM plays a protective role in APAP hepatotoxicity and what mechanisms are involved remain unclear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.019DOI Listing

miRNA-335-5p relieves chondrocyte inflammation by activating autophagy in osteoarthritis.

Life Sci 2019 Apr 7. Epub 2019 Apr 7.

Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China; Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.

Aims: Osteoarthritis (OA) is a chronic and degenerative joint disease prevalent in the elderly, which is characterized by hypertrophy and reactive hyperplasia of articular cartilage. Autophagy has been reported to inhibit inflammation and reduce chondrocyte apoptosis in OA. As the microRNA (miRNA)-335-5p has been linked to both inflammation and autophagy, this study aimed to investigate its potential role in regulating autophagy during the pathogenesis of OA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193024
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http://dx.doi.org/10.1016/j.lfs.2019.03.071DOI Listing
April 2019
4 Reads

Ovarian failure induced by 4-vinylciclohexene diepoxide worsens the autonomic cardiovascular response to chronic unpredictable stress in rats.

Life Sci 2019 Apr 6. Epub 2019 Apr 6.

Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil; Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina - UFSC, Campus, Florianópolis, SC, Brazil. Electronic address:

Aims: After menopause, women are more responsive to stress and more prone to exhibit hypertension, which elevates the risk of cardiac diseases. This vulnerability is due, in part, to the decline of ovarian steroids plasma levels. The 4-vinylciclohexane diepoxide (VCD) causes a gradual depletion of ovarian follicles causing loss of the normal ovarian function and a hormonal profile comparable to menopause in humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193025
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http://dx.doi.org/10.1016/j.lfs.2019.04.007DOI Listing
April 2019
3 Reads

Comment on: Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.

Life Sci 2019 Apr 6. Epub 2019 Apr 6.

Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum D6, 17165 Solna, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.03.075DOI Listing

Progression of micturition dysfunction associated with the development of heart failure in rats: Model of overactive bladder.

Life Sci 2019 Apr 6. Epub 2019 Apr 6.

Laboratory of Multidisciplinary Research, São Francisco University Medical School, Bragança Paulista, SP, Brazil. Electronic address:

Heart failure (HF) has a strong association with the development of lower urinary tract symptoms, especially overactive bladder (OAB); although this condition remains poorly investigated. In this study, we assess the aortocaval fistula (ACF) model as a novel experimental model of micturition dysfunction, associated with HF, focused on the molecular and functional studies to evaluate the autonomic nervous system and urinary bladder remodeling. Male rats were submitted to ACF for HF induction. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.017DOI Listing

Glucagon like peptide 2 has a positive impact on osteoporosis in ovariectomized rats.

Life Sci 2019 Apr 5. Epub 2019 Apr 5.

Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Center for Evidence Based Medicine and Clinical Epidemiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Aims: In this study, we evaluate the effects of glucagon-like peptide 2 (GLP-2) on bone microarchitecture, bone turnover markers (BTMs) and inflammation markers in ovariectomized (OVX) rats.

Material And Methods: In total, 31 Sprague-Dawley rats were divided into the following three groups: sham (control sham-operated with vehicle, n = 7), OV (OVX with vehicle, n = 12), and GLP-2 (OVX with GLP-2, n = 12). Intervention began at the 12th week after surgery and lasted for 4 weeks. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.013DOI Listing
April 2019
2 Reads

Substance P accelerates wound repair by promoting neovascularization and preventing inflammation in an ischemia mouse model.

Life Sci 2019 Apr 5. Epub 2019 Apr 5.

East-West Medical Research Institute, Kyung Hee Medical Science Research Institute, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 02447, Republic of Korea; Kyung Hee Institute of Regenerative Medicine (KIRM), Kyung Hee Medical Science Research Institute, Kyung Hee University Medical Center, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:

Aims: Arterial insufficiency ulcers are frequent complications of peripheral artery disease and infection or long-term neglect of the ulcer can eventually lead to amputation of the affected body part. An ischemic environment, caused by interrupted blood flow, affects the supply of nutrients and elongates the inflammation period, inducing tissue degeneration. Thus, the modulation of neovascularization and inflammation could be an ideal therapeutic strategy for ischemic wound healing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193026
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http://dx.doi.org/10.1016/j.lfs.2019.04.015DOI Listing
April 2019
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Regulatory role of metallothionein-1/2 on development of sex differences in a high-fat diet-induced obesity.

Life Sci 2019 Apr 4. Epub 2019 Apr 4.

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.

Aims: To evaluate the role of metallothionein (MT) in sex differences of obesity, we examined the effect of MT on regulation of lipid accumulation in female and male wild type (WT) and MT1/MT2-null (MT-KO) mice.

Main Methods: Male and female WT and MT-KO mice fed standard diet (SD) or high-fat diet (HFD) for 35 weeks. Surgical castration in male mice was also performed to examine the effects of androgen on fat accumulation under HFD condition. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.012DOI Listing
April 2019
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Toll-like receptor 4 promotes high glucose-induced catabolic and inflammatory responses in chondrocytes in an NF-κB-dependent manner.

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China. Electronic address:

Diabetes is an independent risk factor for knee osteoarthritis (OA), and hyperglycaemia-induced inflammation is considered to play an important role in their connection. The Toll-like receptor 4 (TLR4) regulates inflammatory responses in several pathological conditions including diabetes and OA. However, its role in diabetes-associated OA is poorly understood. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.011DOI Listing
April 2019
5 Reads

Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Biology, National Changhua University of Education, 1 Jin-De Rd., Changhua 50007, Taiwan. Electronic address:

Aim: Fluoxetine (FXT), a selective serotonin reuptake inhibitor (SSRI), is one of the most common psychiatric medications clinically prescribed; while over-produced serotonin may suppress neurite development. The role of major iridoids like geniposide (GPS) and genipin (GNP) from Gardenia jasminoides Ellis fruit (family Rubiaceae) in ameliorating the anti-neurite outgrowth effect of FXT is poorly understood. In this study, the effects of these iridoids on FXT-suppressed neurite outgrowth in Neuro2a neuroblastoma cells were investigated. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.003DOI Listing
April 2019
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HIV-1 Nef-GCC185 interaction regulates assembly of cellular protein complexes at TGN targeting MHC-I downregulation.

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Toxicology and Experimental Medicine Division, CSIR-Central Drug Research Institute, Sector-10, Janakipuram Extension, Sitapur Road, Lucknow 226031, U.P., India. Electronic address:

Aim: HIV-1 Nef downregulates surface MHC-I to protect the infected cells from CTLs-mediated killing. Although MHC-I downregulation has been extensively studied, the Nef-dependent assembly of the multi-protein complex and subsequent pathways activation has not yet been well explored. The present study is aimed for the identification of Nef-mediated sequential recruitment of cellular proteins that constitute the functional multi-protein complex, required for the downregulation of MHC-I. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.008DOI Listing

Chronic paradoxical sleep deprivation-induced depression-like behavior, energy metabolism and microbial changes in rats.

Life Sci 2019 Apr 4. Epub 2019 Apr 4.

Center for Chinese Medicine Therapy and Systems Biology, Institute for Interdisciplinary Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Aims: Given the lasting impact of chronic paradoxical sleep deprivation (PSD) on behavior and organism metabolic alternations, along with the role of the microbiome in neurobehavioral development and metabolism, we sought to examine the relationship between the microbiota and chronic PSD-induced behavioral and metabolic changes.

Materials And Methods: Psychological status of 7-day PSD (7d-PSD) male rats was tested by behavioral method, serum inflammatory cytokines and hypothalamic-pituitary-adrenal (HPA) axis-related hormones. In addition, GC-MS based urine metabolomics and 16S rRNA gene sequencing approaches were applied to estimate the influences of chronic PSD on host metabolism and gut-microbiota. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.006DOI Listing
April 2019
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2.702 Impact Factor

In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats.

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address:

Aims: The gut microbiota plays a crucial role in the efficacy of metformin in T2DM treatment. We evaluated whether the pharmacodynamics and pharmacokinetics of metformin are mediated by gut microbiota.

Main Methods: We used conventional diabetic and pseudo-germ-free rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.009DOI Listing
April 2019
2.702 Impact Factor

Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways.

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

Aims: In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and nucleus, respectively, in cardiomyocytes, but the isoform-specific autophagy regulation of AMPK during MI/R remains unclear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.002DOI Listing
April 2019
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Developing an efficient multiplex PCR method to detect mcr-like genes.

Sci China Life Sci 2019 Apr 2. Epub 2019 Apr 2.

School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China.

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http://dx.doi.org/10.1007/s11427-019-9512-3DOI Listing

Corrigendum to "Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells" [Life Sci. 221 (2019) 35-46].

Life Sci 2019 May 2;224:274. Epub 2019 Apr 2.

School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.03.070DOI Listing
May 2019
3 Reads

Lycium barbarum polysaccharides promote osteoblasts viability by regulating microRNA-17/PTEN.

Life Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Hand and Foot Surgery, Jining No.1 People's Hospital, Jining 272011, China. Electronic address:

Aims: Lycium barbarum polysaccharides (LBPs) have been reported to promote the proliferation of osteoblasts. Further, the proliferation of osteoblasts has been proved to be associated with microRNA (miR)-17 which targets phosphatase and tensin homolog (PTEN) 3'-untranslated region (UTR) for regulating phosphoinositide 3 kinase/protein kinase B (PI3K/AKT) signaling pathway. Consequently, we aimed to explore a miR-17-relative mechanism by which LBPs mediates proliferation of osteoblasts. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.001DOI Listing

Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis.

Life Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, PR China. Electronic address:

Aims: Hydrogen gas (H) has a diversity of effects such as anti-apoptotic, anti-inflammatory and anti-oxidative properties. However, molecular mechanism underlying the potential effect of H on chronic intermittent hypoxia (CIH) induced renal injury remains obscure.

Materials And Methods: In the present study, adult male Sprague-Dawley rats were randomly allocated into four groups: control (CON) group, CIH group, CIH with H treatment (CIH + H) group, and control with H treatment (CON + H) group. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.005DOI Listing
April 2019
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Response to the Questions on Triazoles Binding SMO.

Life Sci 2019 Apr 2. Epub 2019 Apr 2.

Institute of Dermatology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College(PUMC), 12 Jiangwangmiao Street, Nanjing 210042, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.03.076DOI Listing
April 2019
1 Read