32,635 results match your criteria Life sciences[Journal]


Effects of aerobic exercise on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β-AR mice adipose tissue.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Physical Education, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.

Aim: Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β-AR mice adipose tissue.

Main Methods: Four- to five-month-old male wild type (WT) and β-AR mice were divided into groups: WT control (WTc) and trained (WTt); and β-AR control (β-ARc) and trained (β-ARt). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.031DOI Listing
February 2019

Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress induced by intracerebroventricular streptozotocin in male rats.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Sector-125, Noida 201313, India. Electronic address:

Aims: Aegle marmelos (L.) Correa (A. marmelos) has been used in Ayurvedic medicine as a brain tonic however its neuroprotective effect against streptozotocin (STZ) induced cognitive impairment and oxidative stress has not been reported yet in vivo. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.032DOI Listing
February 2019

Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan. Electronic address:

Neutrophil extracellular traps (NETs) are net-like chromatin fibers that can trap and kill microorganisms. Although several anti-inflammatory effects of intravenous anesthetics have been reported, it has not been investigated whether intravenous anesthetics influence NET formation.

Aims: To compare the effects of four intravenous anesthetics (propofol, thiamylal sodium, midazolam, and ketamine) on phorbol myristate acetate (PMA)-induced NET formation and analyze the associated signaling pathways. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.030DOI Listing
February 2019

Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology and Psychopharmacology Research Unit, Marmara University School of Pharmacy, Istanbul, Turkey.

Aims: The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated.

Material And Methods: The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.018DOI Listing
February 2019

Luteolin-induced coronary arterial relaxation involves activation of the myocyte voltage-gated K channels and inward rectifier K channels.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China. Electronic address:

Aims: Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K currents via voltage-gated potassium (Kv) channels and inward rectifier potassium (Kir) channels in freshly isolated rat coronary arterial smooth muscle cells (RCASMCs).

Main Methods: The vascular tone of the endothelium-denuded RCAs was recorded by a wire myograph. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.028DOI Listing
February 2019

Edaravone reduces Aβ-induced oxidative damage in SH-SY5Y cells by activating the Nrf2/ARE signaling pathway.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China. Electronic address:

Aims: Edaravone potentially alleviates cognitive deficits in a mouse model of Alzheimer's disease (AD). However, the mechanism of edaravone in suppressing AD progression remains unclear. We aim to investigate the mechanism of edaravone in suppressing oxidative stress-mediated AD progression in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193011
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http://dx.doi.org/10.1016/j.lfs.2019.02.025DOI Listing
February 2019
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Calcium Dobesilate and Micro-vascular diseases.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.023DOI Listing
February 2019

Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India. Electronic address:

Aims: Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy against DN, present study targeted both, NPS and RAS simultaneously using a neprilysin inhibitor (NEPi) in combination with either angiotensin receptor blocker (ARB) or angiotensin-converting enzyme 2 (ACE2) activator.

Methods: We induced diabetes in male Wistar rats by a single dose of streptozotocin (55 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.027DOI Listing
February 2019

The beneficial roles of exercise training via autophagy in neurological diseases and possible mechanisms.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China; Hebei Provincial Orthopedic Biomechanics key laboratory,The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. Electronic address:

Autophagy is a conservative catabolism process, participating in delivering the cytosol and cytosolic components to the lysosome. Abnormal autophagy is related to human pathologies, for instance diabetes, neurodegeneration, cardiovascular, macular degeneration, pulmonary, and cancer. Enormous evidences indicate that autophagy may mediate the cellular pathological condition in the process of neurological diseases. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.026DOI Listing
February 2019
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Association between duration of endogenous estrogen exposure and cardiovascular outcomes: A population - based cohort study.

Life Sci 2019 Feb 11. Epub 2019 Feb 11.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aims: Duration of endogenous estrogen exposure is apparently associated with risk of cardiovascular disease, the longer durations being more cardiovascular disease protective in women. We aimed to investigate the association of cumulative duration of endogenous estrogen exposure over women's reproductive lifespans with cardiovascular disease outcomes.

Main Methods: For the purpose of the present study, of 10,192 female participants, after excluding those using HRT (n = 84), 3656 women, aged ≥30 years, who met eligibility criteria were selected and divided into three groups based on tertiles (T1, T2, T3) of exposure durations to endogenous estrogen. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.020DOI Listing
February 2019

Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a.

Life Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450000, China. Electronic address:

Aims: The therapeutic strategies for diabetic retinopathy (DR) are disappointing. Ginsenoside Rg1 (Rg1) extracted from Panax ginseng can induce glucose uptake and lower oxidative stress. We aimed to explore the effect of Rg1 on DR using human retinal pigment epithelium cells (ARPE-19). Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.021DOI Listing
February 2019

Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte.

Life Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China. Electronic address:

The neurotoxicity of anesthetics on developing brain has been a focused issue for years. However, controversy exists between human and animal studies and surgery may be a potential reason for this. The discovery of glymphatic system, a pathway eliminating soluble substance from central nervous system (CNS), together with recent evidence that surgery-induced Aβ increase contributes to cognition dysfunction made us rethink about the influence of anesthetics on cognitive function. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.024DOI Listing
February 2019

Non-inflammatory emphysema induced by NO chronic exposure and intervention with demethylation 5-Azacytidine.

Life Sci 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, PR China; Division of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona, Tucson, AZ 85721-0202, USA; Department of Laboratory Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, PR China. Electronic address:

Aims: A rat model of emphysema was established that mimics the features of the human emphysema subtype and explores the effects of demethylation on lung function and blood tests.

Materials And Methods: Rats were randomly assigned to NO, NO + 5-Azacytidine, and normal air groups based on a emphysema rat model induced by chronic NO exposure. This study estimates the characteristics of emphysema by conducting an analysis for IL-6 and TNF-α levels in bronchoalveolar lavage fluids (BALF) and plasma. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.022DOI Listing
February 2019

Retraction notice to: "DUSP1 alleviates cerebral ischaemia reperfusion injury via inactivating JNKMff pathways and repressing mitochondrial fission" [Life Sci. 210 (2018) 251-262].

Life Sci 2019 Feb;219:365

Department of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201399, China.

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http://dx.doi.org/10.1016/j.lfs.2019.02.002DOI Listing
February 2019
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Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy.

Life Sci 2019 Feb 8. Epub 2019 Feb 8.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address:

Aims: Hyperglycemia-mediated oxidative damage has been described as a major mechanism leading to pathologic changes associated with diabetic cardiomyopathy (DCM). Fisetin is a bioactive flavonol molecule found in many plants and possesses various biological activities. The present study investigated the protective effect of fisetin on diabetes-induced cardiac injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.017DOI Listing
February 2019

Early postoperative outcomes of pterygium surgery: Sutures versus autogenous serum in-situ fixation of limbal conjunctival autograft.

Life Sci 2019 Feb 8. Epub 2019 Feb 8.

Department of Ophthalmology, J.J.M. Medical College, Davangere 577004, Karnataka, India.

Limbal Conjunctival Autograft Transplantation (LCAT) is considered to be the most effective treatment option for pterygium with the least recurrence rate and rapid restoration of normal epithelial morphology. Of the many available methods for securing Limbal Conjunctival Autograft (LCAG), sutures and autogenous serum in-situ are cost-effective and offers better outcomes.

Aim: To compare the outcome of surgeries between the two groups: Group I - LCAG secured with autogenous serum in-situ versus Group II - LCAG secured with sutures. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.019DOI Listing
February 2019

Translocator protein 18 kDa ligand alleviates neointimal hyperplasia in the diabetic rat artery injury model via activating PKG.

Life Sci 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, PR China; Chongqing Institute of Cardiology, Chongqing Key Laboratory of Hypertension Research, Chongqing, PR China. Electronic address:

Aims: The proliferation of VSMCs is the pathologic basis for intimal hyperplasia after angioplasty in diabetic patients. Translocator protein (TSPO), located in the outer mitochondrial membrane, has been found to regulate redox intermediate components in cell dysfunction. We hypothesized that TSPO may regulate VSMC proliferation and migration, and be involved in the intimal hyperplasia after angioplasty in diabetes. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.015DOI Listing
February 2019
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Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats.

Life Sci 2019 Feb 7. Epub 2019 Feb 7.

Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Aims: Oxidative stress induced by diabetes mellitus (DM) is considered as one of the main causes of infertility in diabetic patients. The aim of the present study was to assess the effect of Tempol - as a synthetic antioxidant- on the testis oxidative stress and sperm parameters in type 2 diabetic (T2D) rats.

Main Methods: Twenty male Wistar rats were divided into 4 groups. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.016DOI Listing
February 2019
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HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation.

Life Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Paediatrics, First Subsidiary Hospital, University of Science and Technology of He'nan, 471000, China.

Excessive inflammation is fundamental in the pathophysiology of Mycoplasma pneumoniae (MP)-induced respiratory infection in children. Histone deacetylase 5 (HDAC5) is involved in the regulation of inflammation, however, whether it associates with immunity against MP infection is not determined. We report here that HDAC5 expression is decreased in peripheral blood mononuclear cells (PBMCs) from Mycoplasma pneumoniae pneumonia (MPP) children as well as in MP-infected peritoneal and THP-1 macrophages. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.004DOI Listing
February 2019

Systemic microcirculation dysfunction after low thoracic spinal cord injury in mice.

Life Sci 2019 Feb 6. Epub 2019 Feb 6.

Institute of Microcirculation, Key Laboratory of Microcirculation, Ministry of Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

Background: Spinal cord injury (SCI) disturbs the autonomic nervous system and induces dysfunction or failure of multiple organs. The systemic microcirculation disturbance that contributes to the complications associated with SCI remains to be clarified.

Methods: We used male mice (29-32 g) and modified weight-drop injury at T10 to evaluate the systemic microcirculation dysfunction during the first 2 weeks after SCI. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.010DOI Listing
February 2019

Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells.

Life Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China. Electronic address:

Aims: To investigate whether mucin 1 (MUC1) downregulation reduced the sensitivity of tumor necrosis factor-alpha (TNF-α)-induced bronchial epithelial cells to glucocorticoid-mediated necroptosis and explore the underlying mechanisms.

Main Methods: The human lung bronchial epithelial cell line (16HBE) was transfected with small interfering RNA (siRNA) against MUC1 and then stimulated by TNF-α, where some cells were pretreated with dexamethasone. Flow cytometry was performed to analyze necroptosis in 16HBE cells, and western blot analysis was used to detect protein expression levels of MUC1, glucocorticoid receptor (GR)α, GRβ, NF-κB p65, phospho-p65 (p-p65), and histone deacetylase-2 (HDAC2). Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.013DOI Listing
February 2019

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis.

Life Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

Plasmin-mediated fibrinolysis at the surface of vascular endothelial cells (SVEC) plays a key role in maintaining vascular hemostasis, in which the cAMP pathway participates. After externalization to the SVEC, annexin A2 (ANXA2) serves as a platform for conversion of plasminogen to plasmin. Here we describe a regulatory role of the exchange protein directly activated by cAMP (EPAC) in ANXA2 externalization and vascular fibrinolysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193009
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http://dx.doi.org/10.1016/j.lfs.2019.02.014DOI Listing
February 2019
3 Reads

Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries.

Life Sci 2019 Feb 5. Epub 2019 Feb 5.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Peripheral nerve injury (PNI) is a common life-changing disability of peripheral nervous system with significant socioeconomic consequences. Conventional therapeutic approaches for PNI have several drawbacks such as need to autologous nerve scarifying, surplus surgery, and difficult accessibility to donor nerve; therefore, other therapeutic strategies such as mesenchymal stem cells (MSCs) therapy are getting more interesting. MSCs have been proved to be safe and efficient in numerous degenerative diseases of central and peripheral nervous systems. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.052DOI Listing
February 2019
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Intra-bladder wall transplantation of bone marrow mesenchymal stem cells improved urinary bladder dysfunction following spinal cord injury.

Life Sci 2019 Feb 5. Epub 2019 Feb 5.

Faculty of Biomedical Engineering, Sahand University of Technology, Dept. of Biomechanics, Sahand, Iran.

Background: In the most of previous experiments, intrathecal administration of stem cells (SCs) was seen in the management of neurogenic bladder (NGB) following contusion or complete transaction in the rodent model of spinal cord injury (SCI). Here, we aimed to investigate whether intra bladder wall autologous bone marrow mesenchymal SC (BM-MSCs) transplantation, as a minimally invasive method, could improve bladder dysfunctions after a chronic phase of hemi- and complete-transection SCI in a female rat model.

Material And Methods: A total of forty-two female Wistar rats were randomly divided into 6 groups (each in 7) and subjected to complete and incomplete spinal cord transection by a laminectomy at the T9 vertebral level. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.011DOI Listing
February 2019
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Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells.

Life Sci 2019 Feb 5. Epub 2019 Feb 5.

School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. Electronic address:

Aim: Alzheimer's disease (AD), a neurodegenerative disease, is characterized by memory loss and synaptic damage. Up to now, there are limited drugs to cure or delay the state of this illness. Recently, the Fyn tyrosine kinase is implicated in AD pathology triggered by synaptic damage. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.012DOI Listing
February 2019
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Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction.

Life Sci 2019 Feb 4. Epub 2019 Feb 4.

Department of Anesthesiology, University of California, the Veterans Affairs San Diego Healthcare System, La Jolla, San Diego, CA, United States of America. Electronic address:

Aims: To determine the metabolic adaptations to compensated heart failure using a reproducible model of myocardial infarction and an unbiased metabolic screen. To address the limitations in sample availability and model variability observed in preclinical and clinical metabolic investigations of heart failure.

Main Methods: Metabolomic analysis was performed on serum and myocardial tissue from rabbits after myocardial infarction (MI) was induced by cryo-injury of the left ventricular free wall. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.040DOI Listing
February 2019
1 Read

Erythromycin relaxes BALB/c mouse airway smooth muscle.

Life Sci 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. Electronic address:

Aims: Bitter taste receptor (TAS2R) agonists have bronchodilatory potentials. Erythromycin is a ligand of TAS2R10, but its relaxant profile is unknown. This study was performed to understand the relaxant effects of erythromycin and its potential mechanism. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.009DOI Listing
February 2019

Losartan treatment attenuates the development of neuropathic thermal hyperalgesia induced by peripheral nerve injury in rats.

Life Sci 2019 Mar 4;220:147-155. Epub 2019 Feb 4.

Department of Functional Morphology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

Aims: Neuroinflammatory changes in the central nervous system are widely involved in the initiation and maintenance of neuropathic pain after peripheral nerve injury. The present study investigated how losartan treatment may affect the development of neuropathic pain and neuroinflammation.

Main Methods: The effect of losartan treatment on the development of peripheral neuropathy was studied in L5 spinal nerve ligation (SNL) model in rats with systemic (100 mg/kg) or intrathecal (10 μl/ 20 μM solution) application of losartan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193008
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http://dx.doi.org/10.1016/j.lfs.2019.02.008DOI Listing
March 2019
8 Reads

Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGE/PI3K/Akt pathway and downstream inflammatory cascades.

Life Sci 2019 Feb 3. Epub 2019 Feb 3.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, Egypt.

Aims: The herbicide paraquat causes fatal lung toxicity by induction of xanthine oxidase, free radicals and inflammation. Febuxostat, a xanthine oxidase inhibitor and anti-gout has recently shown anti-inflammatory activity. Accordingly, this study was carried out to investigate whether febuxostat may attenuate paraquat-induced lung toxicity and to explore the possible underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.007DOI Listing
February 2019
1 Read

Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress.

Life Sci 2019 Feb 2. Epub 2019 Feb 2.

Kidney Research Centre, University of Ottawa, Canada; Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK. Electronic address:

Vascular inflammatory responses play an important role in several cardiovascular diseases. Of the many pro-inflammatory vasoactive factors implicated in this process, is aldosterone, an important mediator of vascular oxidative stress. Statins, such as atorvastatin, are cholesterol-lowering drugs that have pleiotropic actions, including anti-oxidant properties independently of their cholesterol-lowering effect. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.043DOI Listing
February 2019

Exosomal miRNAs from highly metastatic cells can induce metastasis in non-metastatic cells.

Life Sci 2019 Mar 2;220:162-168. Epub 2019 Feb 2.

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Aims: Breast cancer is a high prevalence cancer among women worldwide. 15-20% of breast cancer cases are triple-negative with a poor prognosis. miRNA aberrant expression is one of the reasons of cancer development and metastasis. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.057DOI Listing
March 2019
1 Read

Spatiotemporal chromatin dynamics - A tell tale of circadian epigenetic gene regulation.

Life Sci 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.

Over the course of evolution, nature has forced organisms under selection pressure to hardwire an internal time keeping device that defines 24 h of daily cycle of physiological and behavioral rhythms, known as circadian rhythms. At the cellular level, the cycle is governed by significant fractions of transcriptomes, which are under the control of transcriptional and translational feedback loop of clock genes. Intriguingly, this feedback loop is regulated at multiple stratums such as at the transcriptional and translational levels, which direct a cell towards producing a robust rhythm by sustaining the repeated stoichiometry of protein products. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193008
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http://dx.doi.org/10.1016/j.lfs.2019.02.006DOI Listing
February 2019
9 Reads

Toxic effects of magnetic nanoparticles on normal cells and organs.

Life Sci 2019 Mar 1;220:156-161. Epub 2019 Feb 1.

Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China. Electronic address:

Magnetic nanoparticles (MNPs) are promising candidates for drug delivery and treatment of various disorders. Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention. Formulations involving individual or combinatorial nanoparticle suspensions might be used for targeted delivery and treatment. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.056DOI Listing

KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT.

Life Sci 2019 Mar 2;220:169-176. Epub 2019 Feb 2.

Applied Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address:

Aims: Insensitivity of cancer cells to therapeutic drugs is the most daunting challenge in cancer treatment. The mechanism of developing chemo-resistance is only partly understood to date. In continuation of some earlier reports, we hypothesize that KLF4, a key transcription factors that also has a crucial role in maintaining the stemness in cancer cells, may offer a basis for chemo-resistance. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.005DOI Listing
March 2019
2.702 Impact Factor

Leukemia-derived exosomes induced IL-8 production in bone marrow stromal cells to protect the leukemia cells against chemotherapy.

Life Sci 2019 Feb 2. Epub 2019 Feb 2.

Department of Hematology, The Affiliated Hospital of Gulin Medical University, Guilin, China. Electronic address:

Aims: The interplay between bone marrow stromal cells (BMSCs) and acute myeloid leukemia (AML) cells plays a critical role in AML drug resistance by secreting growth factors, cytokines, and extracellular vesicles. As kind of extracellular vesicles, exosomes consist of proteins and RNAs and regulate communication among cells.

Main Methods: The BMSCs, HS5 cells, and AML cells were co-cultivated with transwell membranes, and treated with different doses of AML chemotherapy drug, etoposide. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.003DOI Listing
February 2019
2 Reads

CircRNAs and lung cancer: Biomarkers and master regulators.

Life Sci 2019 Mar 31;220:177-185. Epub 2019 Jan 31.

Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

CircRNAs are a class of competitive, endogenous, non-coding RNAs with closed-loop structures. High-throughput sequencing indicates that circRNAs are ubiquitously expressed in many eukaryotes. Biological functions of circRNAs include interaction with proteins and regulation of gene transcription, translation, and miRNA sponge activity. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.055DOI Listing

Surface functionalized folate targeted oleuropein nano-liposomes for prostate tumor targeting: Invitro and invivo activity.

Life Sci 2019 Mar 31;220:136-146. Epub 2019 Jan 31.

Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia. Electronic address:

Aims: This study aims to develop and evaluate oleuropein loaded surface functionalized folate-targeted - PEG liposomes for the effective management of prostate cancer in an animal model.

Materials And Methods: Film hydration-cum-extrusion technique was used to produce liposomes. Particle size, entrapment efficiency, drug loading, electron microscopy, and drug release study were performed for the characterization. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.053DOI Listing
March 2019
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2.702 Impact Factor

MiR-199a-3p mediates the adipogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating KDM6A/WNT signaling.

Life Sci 2019 Mar 30;220:84-91. Epub 2019 Jan 30.

Department of Stomatology, Jin Ling Hospital (Nanjing General Hospital of Nanjing Military Command), Medical School of Nanjing University, Nanjing, Jiangsu 210002, People's Republic of China. Electronic address:

A number of evidences suggest that microRNAs are involved in the adipogenic commitment of mesenchymal stem cells (MSCs). Recent studies have investigated that miR-199a-3p played a pivotal role in adipocyte differentiation. However, the detailed mechanism in this complex biological process remains largely unknown. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.051DOI Listing

Brain cholesterol metabolite 24-hydroxycholesterol modulates inotropic responses to β-adrenoceptor stimulation: The role of NO and phosphodiesterase.

Life Sci 2019 Mar 30;220:117-126. Epub 2019 Jan 30.

Institute of Neuroscience, Kazan State Medical University, Butlerova st. 49, Kazan 420012, Russia; Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, Federal Research Center "Kazan Scientific Center of RAS", P. O. Box 30, Lobachevsky Str., 2/31, Kazan 420111, Russia. Electronic address:

Aims: 24-Hydroxycholesterol (24HC) is the main brain cholesterol metabolite, which level in the circulation is significantly changed under physiological and pathological conditions. Here, we have studied the effect of 24HC on the inotropic responses to β-adrenoceptor (AR) stimulation.

Main Methods: Electrical stimulation-evoked contractions were recorded in isolated atria from mice. Read More

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Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells.

Life Sci 2019 Jan 29. Epub 2019 Jan 29.

Department of Thoracic Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China; The Third Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710068, China; Department of Cardiothoracic Surgery, The Northwest Women and Children Hospital, Xi'an 710061, China. Electronic address:

Aims: Honokiol is a hydroxylated biphenyl natural product and displays potent antitumor activity against several cancers including prostate cancer, melanoma, leukemia, and colorectal cancer. The present study was to investigate the in vitro activity of honokiol against A549 and 95-D human lung cancer cells.

Main Methods: A549 and 95-D cells were used with honokiol treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193005
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http://dx.doi.org/10.1016/j.lfs.2019.01.046DOI Listing
January 2019
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Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation.

Life Sci 2019 Jan 29. Epub 2019 Jan 29.

Central Laboratory of the First Affiliated Hospital, Jinan University, Guangzhou 510630, China. Electronic address:

Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platform, a chemical compound Linifanib was identified as a potent inducer of UCP1 expression in primary inguinal adipocytes in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.047DOI Listing
January 2019
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2.702 Impact Factor

The role of the BMP4/Smad1 signaling pathway in mesangial cell proliferation: A possible mechanism of diabetic nephropathy.

Life Sci 2019 Mar 29;220:106-116. Epub 2019 Jan 29.

Department of Nephrology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address:

Aims: This study explored the role of the BMP4/Smad1 signaling pathway in mesangial matrix expansion during the process of diabetic nephropathy.

Main Methods: Diabetic rats were induced by high-fat feeding followed by an intraperitoneal injection of streptozotocin. Glomerular lesions were examined. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.049DOI Listing
March 2019
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Binge ethanol and MDMA combination exacerbates HSP27 and Trx-1 (biomarkers of toxic cardiac effects) expression in right ventricle.

Life Sci 2019 Mar 29;220:50-57. Epub 2019 Jan 29.

Department of Pharmacology, Faculty of Medicine, University of Murcia, Spain; Instituto Murciano de Investigación Biosanitaria, Murcia, Spain.

Aims: Oxidative stress caused by exposure to drugs of abuse such as ethanol or 3, 4 methylenedioxymethamphetamine (MDMA) may derive from direct or indirect effects in many organs including the heart. The aim of the present work was to evaluate cardiac sympathetic activity and the expression and activation of two antioxidant proteins: heat shock protein27 (HSP27) and thioredoxin-1 (Trx-1) after voluntary binge ethanol consumption, alone and in combination with MDMA.

Material And Methods: Adolescent mice received MDMA, ethanol or both. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.050DOI Listing
March 2019
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Immunophenotypic profile of leukocytes in hyperandrogenemic female rat an animal model of polycystic ovary syndrome.

Life Sci 2019 Mar 29;220:44-49. Epub 2019 Jan 29.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, United States of America; Women's Health Research Center, University of Mississippi Medical Center, United States of America. Electronic address:

The immune etiology of polycystic ovary syndrome (PCOS) is an intriguing area. However, whether there is alteration in the leukocyte populations in different tissues remain ambiguous.

Aim: To characterize the leukocyte populations of hyperandrogenemic female (HAF) rat tissues. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.048DOI Listing
March 2019
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Hyperoxia improves carbohydrate metabolism by browning of white adipocytes in obese type 2 diabetic rats.

Life Sci 2019 Mar 28;220:58-68. Epub 2019 Jan 28.

Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Aims: Type 2 diabetes and obesity are associated with chronic hypoxia, which contributes to adipose tissue dysfunction and development of insulin resistance and metabolic disorders. We assessed long-term effects of hyperoxia on browning of adipocytes and carbohydrate metabolism in a murine model of type 2 diabetes.

Main Methods: Male Wistar rats (190-210 g) were divided into 4 groups: Control, O-treated control, untreated diabetes, and O-treated diabetes. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.045DOI Listing
March 2019
2.702 Impact Factor

Bi-directional regulation of TGF-β/Smad pathway by arsenic: A systemic review and meta-analysis of in vivo and in vitro studies.

Life Sci 2019 Mar 28;220:92-105. Epub 2019 Jan 28.

Department of Public Health, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, China. Electronic address:

Background: Arsenic exposure can cause fibrosis of organs including the liver, heart and lung. It was reported that TGF-β/Smad pathway played a crucial role in the process of fibrosis. However, the mechanism of arsenic-induced fibrosis through TGF-β/Smad signaling pathway has remained controversial. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.042DOI Listing
March 2019
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Novel hepacivirus in Asian house shrew, China.

Sci China Life Sci 2019 Jan 28. Epub 2019 Jan 28.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

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http://dx.doi.org/10.1007/s11427-018-9435-7DOI Listing
January 2019
1.688 Impact Factor

Chitosan/LiCl composite scaffolds promote skin regeneration in full-thickness loss.

Sci China Life Sci 2019 Jan 28. Epub 2019 Jan 28.

Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing, 100853, China.

Small molecules loaded into biological materials present a promising strategy for stimulating endogenous repair mechanisms for in situ skin regeneration. Lithium can modulate various biologic processes, promoting proliferation, angiogenesis, and decreasing inflammation. However, its role in skin repair is rarely reported. Read More

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http://dx.doi.org/10.1007/s11427-018-9389-6DOI Listing
January 2019
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Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1.

Life Sci 2019 Jan 27. Epub 2019 Jan 27.

Division of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address:

Aims: The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.

Main Methods: Diabetes was induced in rats through a single intraperitoneal injection of streptozotocin. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.044DOI Listing
January 2019
2 Reads