Search Our Scientific Publications & Authors

Cureus 2020 Jun 12;12(6):e8572. Epub 2020 Jun 12.

Pathology and Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, USA.

Lichen spinulosus (LS) is an uncommon skin condition mostly in children and adolescents but uncommon in adults. It presents as a group of hypopigmented or skin-colored follicular papules and keratotic spines with a sandpaper-like appearance. There is a lymphohistiocytic infiltrate in the dermis centered around hair follicles. Read More

Dermatol Ther (Heidelb) 2020 Aug 12;10(4):887-892. Epub 2020 Jun 12.

Department of Dermatology, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.

Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare variant of lichen planopilaris, characterized by a triad of clinical signs including follicular spinous papules on the body area, scarring alopecia of the scalp and non-scarring alopecia of the groin and/or axilla. To date, fewer than 50 cases have been described in the literature. We first report a case of GLPLS investigated with non-invasive techniques such as dermoscopy and in vivo reflectance confocal microscopy (RCM) and successfully treated with narrowband-UVB (NB-UVB) phototherapy. Read More

Dermatol Pract Concept 2018 Oct 31;8(4):299-302. Epub 2018 Oct 31.

Department of Skin & VD, Patna Medical College and Hospital, Patna, Bihar, India.

Background: Diagnosing and differentiating pityriasis rubra pilaris (PRP) from other disorders can be a challenging task. Although histopathology remains the gold standard, it may not be feasible at times, especially in children. Being noninvasive, dermoscopy can be of great diagnostic importance in such a scenario. Read More

J Dtsch Dermatol Ges 2017 Mar;15(3):289-301

Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkei.

Hintergrund Und Ziel: Als seltene Form der Mycosis fungoides (MF), ist die follikulotrope MF (FMF) durch ein breites Spektrum klinischer Symptome gekennzeichnet. Dazu gehören, neben den vorherrschenden follikulären Läsionen, auch viele atypische Manifestationen. Das Ziel der vorliegenden Studie war eine klinische Bewertung von FMF-Patienten, unter besonderer Berücksichtigung von vernachlässigten dermatologischen Merkmalen. Read More

J Dtsch Dermatol Ges 2017 Mar 27;15(3):289-299. Epub 2017 Feb 27.

Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Background And Objective: A rare variant of mycosis fungoides (MF), folliculotropic MF (FMF) is characterized by a broad clinical spectrum that primarily includes follicle-based lesions but also many atypical clinical manifestations. The objective of the present study was to conduct a clinical analysis of patients with FMF, with a particular focus on highlighting underrecognized dermatological features.

Patients And Methods: Overall, 27 FMF patients enrolled in our department';s MF registry, which includes 572 patients, were retrospectively reevaluated with regard to demographics, clinical features, treatment modalities, follow-up, and outcomes. Read More

Eur J Dermatol 2015 Sep-Oct;25(5):490-1

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.

Ann Dermatol Venereol 2014 Jun-Jul;141(6-7):482-4. Epub 2014 Jun 2.

Service de dermatologie, centre hospitalier régional d'Orléans, 1, rue Porte-Madeleine, 45032 Orléans, France.

Arch Dermatol 2012 Jul;148(7):865-6

Clin Exp Dermatol 2011 Jul 21;36(5):557-8. Epub 2011 Mar 21.

J Am Acad Dermatol 2012 Jul 3;67(1):e49-55. Epub 2010 Nov 3.

Department of Dermatology, Royal Perth Hospital, Perth, Australia.

Background: Multiple minute digitate hyperkeratosis (MMDH) is a rare disorder of keratinization with many different names.

Objective: We present a case of MMDH and review the literature. We propose and discuss the classification the digitate keratoses, which include MMDH, lichen spinulosus, phrynoderma, spiny keratoderma, arsenical keratosis, multiple filiform verrucae, postirradiation digitate keratosis, trichodysplasia spinulosa, and hyperkeratotic spicules. Read More

Pediatr Dermatol 2010 Sep-Oct;27(5):546-7. Epub 2010 Aug 27.

Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busanjin-gu, Busan, Korea.

Lichen spinulosus (LS) is a rare idiopathic cutaneous eruption characterized by follicular keratotic spiny papules that are grouped in large patches. Here, we report two cases of LS in the submental area, an uncommon site, which were treated effectively and safely with topical tacalcitol cream. Read More

Dermatology 2009 17;219(4):350-2. Epub 2009 Sep 17.

Department of Dermatology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama City, Osaka 589-8511, Japan.

Pityriasis rubra pilaris (PRP) is a papulosquamous disorder comprising 6 clinical types. Some factors - including abnormal vitamin A metabolism, internal malignancies, autoimmune diseases, infection and trauma - are thought to be involved in the etiology. Recently, human immunodeficiency virus (HIV)-associated PRP has been reported to have distinct clinical features, such as nodulocystic acne and lichen spinulosus alongside PRP. Read More

Acta Derm Venereol 2009 ;89(3):311-2

Eur J Dermatol 2007 Nov-Dec;17(6):544-5. Epub 2007 Oct 19.

Maltepe University School of Medicine, Department of Dermatology, Istanbul, Turkey.

Arch Dermatol 2007 Jan;143(1):122-3

Clin Exp Dermatol 2005 Jul;30(4):452-3

J Am Acad Dermatol 2004 Oct;51(4):606-24

New York University School of Medicine, Medical College of Wisconsin, Milwaukee, USA.

Lichenoid eruptions are quite common in children and can result from many different origins. In most instances the precise mechanism of disease is not known, although it is usually believed to be immunologic in nature. Certain disorders are common in children, whereas others more often affect the adult population. Read More

Postgrad Med J 2002 Feb;78(916):114-5

Department of Internal Medicine B, Bnai Zion Medical Center, and Technion Faculty of Medicine, Israel.

Omeprazole is a potent proton pump inhibitor and usually is well tolerated. Adverse effects of this drug have been reported in up to 5% of patients, most of which are trivial and disappear rapidly on discontinuation of the drug. Skin adverse reactions attributed to omeprazole are uncommon and include rashes, urticaria, angio-oedema, acute disseminated epidermal necrolysis, lichen spinulosus, and contact dermatitis. Read More

Arch Dermatol 2000 Sep;136(9):1165-70

Raymond Bliss Army Hospital, Fort Huachuca, Ariz., USA.

Br J Dermatol 1999 May;140(5):931-4

Departments of Dermatology, Río Hortega University Hospital, Valladolid, Spain.

HIV-associated pityriasis rubra pilaris (PRP) or PRP type VI designates a new distinctive entity reported in HIV patients. It is characterized by cutaneous lesions of PRP and variable association with lesions of acne conglobata, hidradenitis suppurativa and lichen spinulosus. We report a patient with HIV-associated PRP which was treated by triple antiretroviral therapy (zidovudine, lamivudin and saquinavir) with complete response. Read More

Br J Dermatol 1995 Dec;133(6):990-3

Servicio de Dermatología Unisversidad Alcalá de Henares, Hospital Ramón y Cajal, Madrid, Spain.

Recently, the occurrence of pityriasis rubra pilaris (PRP) has been reported in patients with HIV infection. It presents different clinical features, and has a poorer prognosis, than the classical adult type of PRP. We report the occurrence of severe PRP in an HIV-infected patient, and review the previously reported cases of this association. Read More

Int J Dermatol 1995 Sep;34(9):670-1

J Am Acad Dermatol 1992 Jun;26(6):1013-4

Department of Dermatology, University of North Carolina, Chapel Hill 27514.

J Am Acad Dermatol 1991 Jul;25(1 Pt 1):116-8

Department of Dermatology, Mayo Clinic, Rochester, MN 55905.

J Am Acad Dermatol 1990 Feb;22(2 Pt 1):261-4

Dermatology Division, School of Medicine, University of California, Los Angeles.

Lichen spinulosus is a rare, idiopathic dermatosis characterized by follicular keratotic papules that are grouped into large patches. In this report the clinical and histologic data of 35 patients with lichen spinulosus are presented. The patients consisted of 14 males and 21 females, and their average age was 17. Read More

Cutis 1989 Jun;43(6):557-60

Texas Tech University Health Sciences Center, Department of Dermatology, Lubbock 79430.

Lichen spinulosus is a benign follicular eruption seen primarily in younger persons and is frequently classified among the follicular keratoses. Grouped patches of spinous papules are seen involving the elbows, knees, and buttocks. An atopic background is frequently present in these patients. Read More

Med J Aust 1989 Apr;150(7):410

Med Cutan Ibero Lat Am 1988 ;16(3):183-6

Servicio de Dermatología, Facultad de Medicina, Hospital Clínico, Valencia.

Lectins are used to study four cases of keratosis pilaris, four of lichen spinulosus, 11 of porokeratosis, 8 of striated lichen and one case of pityriasis rubra pilaris, with the aim of providing data to improve knowledge of the histogenesis of these processes. Read More

Cutis 1984 Feb;33(2):197-200

A typical case of lichen spinulosus in a 15-year-old boy is described. Keratotic papules and plaques occurred on the knees, elbows, and lower legs. A biopsy showed follicular hyperkeratosis consistent with lichen spinulosus. Read More

Cutis 1976 Feb;17(2):294-99

Two cases of lichen spinulosus and the response to therapy with Keralyt under occlusion are presented. It is evident that Keralyt under occlusion for two consecutive weeks will clear these lesions. However, twice weekly application of Keralyt must be used in order to keep these areas free of lesions. Read More