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MMW Fortschr Med 2022 Jun;164(11):28-29

Umweltmedizin, Universitätsklinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

J Low Genit Tract Dis 2022 May 8. Epub 2022 May 8.

Private Practice, Epping, Australia.

Objective: The aim of the study was to evaluate clinicopathologic features of cases demonstrating an acanthotic tissue reaction not clearly consistent with psoriasis, lichen simplex chronicus, mycosis, or condyloma.

Materials And Methods: This is a retrospective pathologic case series of biopsies reported as "benign acanthotic lesion" and "acanthotic tissue reaction" that lacked a clear diagnosis on expert review. Cases with nuclear atypia were excluded. Read More

J Menopausal Med 2022 Apr;28(1):42-45

Department of Obstetrics and Gynecology, School of Medicine, Texas Tech University Health Sciences Center (TTUHSC) at the Permian Basin, Odessa, TX, USA.

Lichen simplex chronicus commonly presents as a distressing vaginal lesion caused by severe, cyclical itch-scratch behavior. Lichen simplex chronicus is diagnosed by obtaining a detailed medical history, performing a physical exam, and recording of self-reported symptoms. Lichen simplex chronicus can be treated by corticosteroids, immunomodulators, antiepileptics, antihistamines, antidepressants, and phototherapy. Read More

Cureus 2022 Apr 5;14(4):e23850. Epub 2022 Apr 5.

Dermatology, University of California Davis Medical Center, Sacramento, USA.

Cannabidiol is a member of the cannabinoids, consisting of a diverse class of compounds derived from . There are three types of cannabinoids based on origin: endocannabinoids (endogenous), phytocannabinoids (plant-derived), and synthetic cannabinoids (synthesized). The endocannabinoid system plays a key role in skin homeostasis, such as proliferation, differentiation, and inflammatory signaling. Read More

Int J Gynecol Pathol 2022 May 12;41(3):298-306. Epub 2021 Nov 12.

Accurate diagnosis of differentiated vulvar intraepithelial neoplasia (dVIN) is challenging, in part due to the sometimes subtle nature of its atypia. Many dVIN lesions demonstrate aberrant p53 staining; however, staining patterns overlap between dVIN and benign/reactive entities. We evaluate a p53/CK17 dual stain in an initial cohort of dVIN (n=30), benign vulvar skin (n=5), lichen sclerosus (LS, n=10), lichen simplex chronicus (LSC, n=10), and pseudoepitheliomatous hyperplasia (PEH, n=10). Read More

Mod Pathol 2022 Apr 18. Epub 2022 Apr 18.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Vulvar squamous cell carcinomas and their precursors are currently classified by the World Health Organization based on their association with high-risk human papillomavirus (HPV). HPV independent lesions often harbor driver alterations in TP53, usually seen in the setting of chronic vulvar inflammation. However, a group of pre-invasive vulvar squamous lesions is independent from both HPV and mutant TP53. Read More

Actas Dermosifiliogr 2022 Mar 1;113(3):T244-T253. Epub 2021 Nov 1.

School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, China; Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing, China; Institute of Child Development and Education, Southeast University, Nanjing, China. Electronic address:

Background: Prurigo nodularis (PN) as an extremely pruritic and hyperplastic chronic dermatosis induces psychologically and physiologically stressful responses. PN-induced responses in the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-gonadal axes and endocannabinoid system are abnormal. Extant studies on the PN's pathogenesis mostly focused on the PN's psychological responses. Read More

Actas Dermosifiliogr 2022 Mar 8;113(3):244-253. Epub 2022 Feb 8.

School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, China; Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing, China; Institute of Child Development and Education, Southeast University, Nanjing, China. Electronic address:

Background: Prurigo nodularis (PN) as an extremely pruritic and hyperplastic chronic dermatosis induces psychologically and physiologically stressful responses. PN-induced responses in the hypothalamic-pituitary-adrenal (HPA), hypothalamic-pituitary-gonadal (HPG) axes and endocannabinoid system (ECS) are abnormal. Extant studies on the PN's pathogenesis mostly focused on the PN's psychological responses. Read More

Pediatr Dermatol 2022 Mar 17;39(2):226-230. Epub 2022 Feb 17.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.

Background/objectives: The psychosocial impact of pediatric skin conditions can be difficult to assess accurately. There is currently no way to formally screen and provide stepped care specifically for psychosocial dysfunction or mental illness during dermatology clinics. The Psychosocial Screening Tool for Pediatric Dermatology (PDPS) was designed to identify patients in need of psychosocial support and to promote multidisciplinary care. Read More

J Eur Acad Dermatol Venereol 2022 06 17;36(6):e486-e488. Epub 2022 Feb 17.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Dermatitis 2022 Jan 5. Epub 2022 Jan 5.

From the Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Foot eczema in children is a commonly encountered condition but is associated with diverse etiology, thereby posing a diagnostic challenge. These include atopic eczema, juvenile plantar dermatoses, irritant contact dermatitis, and allergic contact dermatitis. Because of the diverse etiology, it is often difficult to distinguish between the conditions clinically, thereby warranting patch testing for the correct diagnosis. Read More

Exp Dermatol 2022 05 13;31(5):781-788. Epub 2022 Jan 13.

Departments of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

The pathogenesis of inflammatory skin diseases is associated with the abnormal activity of keratinocytes and immune cells infiltrate. Vitamin D deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D influences inflammatory skin diseases still requires clarification. Read More

Acta Dermatovenerol Croat 2021 Dec;29(3):169-170

Diego Abbenante, MD, Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Bologna, Via Massarenti 1, 40100, Bologna, Italy;

Dear Editor, A 45-year-old man presented with a large, dark, keratotic, warty, and friable plaque on the distal posterior aspect of the left leg (Figure 1, a). The patient reported that the lesion was not present at birth but had appeared approximately at the age of three as an erythematous patch that progressively grew over the time. During adolescence, the surface of the lesion became rough and warty and was easily traumatized due to its location, resulting in recurrent bleeding episodes over a period of years. Read More

Indian Dermatol Online J 2021 Nov-Dec;12(6):892-895. Epub 2021 Nov 22.

Department of Dermato-Venereo-Leprology, Government Medical College and Hospital, Nagpur, Maharashtra, India.

Chronic acral hyperkeratotic dermatosis includes several conditions such as lichen simplex chronicus (LSC), hypertrophic lichen planus (HLP), psoriasis vulgaris (Ps), acral acanthosis nigricans, acquired zinc deficiency, and necrolytic acral erythema (NAE). LSC, Ps, and HLP respond to conventional treatments such as topical corticosteroids, immuno-modulators such as tacrolimus, and oral methotrexate. Zinc-responsive acral hyperkeratosis is a novel entity that resembles the above mentioned diagnoses clinically but fails to respond to the above treatment options. Read More

Am J Ophthalmol Case Rep 2021 Dec 25;24:101237. Epub 2021 Nov 25.

Department of Ophthalmology and Visual Science, State University of New York Upstate Medical University, 750 E Adams Street, NY, 13210, USA.

Purpose: To report a case of lichen simplex chronicus (LSC) of the eyelid and to perform a literature review on this topic.

Observations: A 59-year-old African American man presents with chronic and recalcitrant recurrent chalazion of both upper eyelids despite aggressive medical management. An incision and drainage procedure was performed along with biopsy of the eyelid, which was found to be consistent with LSC. Read More

J Refract Surg 2021 Dec 1;37(12):816-823. Epub 2021 Dec 1.

Purpose: To assess the occurrence of risk factors for progression of keratoconus and failure rate after corneal cross-linking (CXL) in patients with progressive keratoconus.

Methods: This retrospective study observed 230 eyes of 173 patients with a minimum follow-up of 36 months after CXL. A total of 185 eyes underwent CXL once (80%) (control) and 45 (20%) underwent this treatment more than once (Re-CXL-group). Read More

Ann Pathol 2022 Jan 10;42(1):49-57. Epub 2021 Dec 10.

Service de pathologie, hôpital Cochin, Paris 14e, cabinet de dermatopathologie Mathurin-Moreau, Paris 19(e), France. Electronic address:

Lichen sclerosus, lichen planus, psoriasis and plasma cell vulvitis are the most common diagnosis amongst inflammatory vulval diseases, the most frequently suspected by the clinicians and the most frequently diagnosed by the pathologist. We expose their clinical and pathological aspects and detail the most recurrent diagnosis difficulties. Read More

Dermatol Ther 2022 03 30;35(3):e15259. Epub 2021 Dec 30.

Department of Dermatology, Icahn School of Medicine, Mount Sinai Medical Center and Health System, New York, New York, USA.

Atopic dermatitis (AD) is frequently misdiagnosed and undertreated, resulting in increased morbidity. In 2019, the Atopic Dermatitis Quality of Care Initiative was launched globally to investigate barriers to AD care and note good practice interventions to improve care. The initiative included a literature review to define the challenges in AD and a survey of 32 AD centers to define good practice interventions. Read More

J Geriatr Oncol 2022 04 22;13(3):282-286. Epub 2021 Nov 22.

Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address:

Vulvar dermatoses are often debilitating chronic skin conditions associated with pain and pruritus. In oncologic patients, cancer treatments can precipitate and exacerbate vulvar dermatoses. Cytotoxic chemotherapy, hormonal therapies, and local pelvic radiation therapy can lead to vulvar symptoms, and cancer treatment-induced vulvar conditions include graft-versus-host-disease and radiation dermatitis. Read More

BMC Public Health 2021 11 20;21(1):2134. Epub 2021 Nov 20.

Department for Occupational and Environmental medicine, Bavarian Health and Food Safety Authority, Pfarrstraße 3, Munich, Germany.

Background: Concerns about smoking displacement from public places to private amenities aroused following smoking ban implementation in Bavaria in 2008. We analysed children's exposure to second-hand smoke (SHS) before and after the ban, its effect on children's health and prevalence of active smoking in adults.

Methods: Six cross-sectional surveys (n = 32,443) on pre-school children in Bavaria were analysed, two surveys before the smoking ban in years 2004 and 2005 (S1 and S2) and four after the ban in 2008, 2012, 2014 and 2016 (S4, S6, S7 and S8). Read More

Arch Clin Cases 2019 27;6(3):59-68. Epub 2021 Oct 27.

Department of Morphofunctional Sciences I - Histology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter's syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. They create a diagnostic challenge, both clinical and histopathological, because of their complexity and frequent overlapping of the microscopical features. The characteristic histopathological features of psoriasiform reaction comprise extensive hyperkeratosis, with horizontally confluent but vertically intermittent parakeratosis, which alternate with orthokeratosis, thin granular layer, with relative frequent mitoses, uniform elongated and fused rete ridges, edematous superficial papillary dermis, with dilated capillaries, perivascular lymphocytic infiltrate, Munro's microabscesses, and spongiform pustules of Kogoj. Read More

An Bras Dermatol 2021 Nov-Dec;96(6):700-705. Epub 2021 Oct 4.

Department of Biochemistry, Şişli Etfal Training and Research Hospital, Health Sciences University, Istanbul, Turkey.

Background: Lichen simplex chronicus is a dermatological condition due to excessive scratching, with few studies on psychoneuroimmunology.

Objective: We aimed to estimate the levels of stress, depression, and anxiety, and to measure serum levels of neurotrophins in patients with lichen simplex chronicus, and to correlate these parameters with the severity of the disease and pruritus.

Methods: Thirty-six patients with lichen simplex chronicus and 36 age- and sex-matched healthy controls were included. Read More

Clin Cosmet Investig Dermatol 2021 15;14:1247-1251. Epub 2021 Sep 15.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xian, People's Republic of China.

Purpose: Keratin 17 (K17) is an embryonic keratin and overexpression is seen in psoriasis, which is a hyperproliferation skin disease. Nonetheless, whether it is also highly expressed in other proliferative skin diseases remains unclear. The aim of this study is to explore the expression of K17 in cutaneous lichen planus (CLP), lichen simplex chronicus (LSC), and prurigo nodularis (PN). Read More

J Invest Dermatol 2022 03 15;142(3 Pt A):731-735.e3. Epub 2021 Sep 15.

Millennium Nucleus for the Study of Pain (MiNuSPain), Chile; Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

Dermatology 2022 26;238(2):368-376. Epub 2021 Aug 26.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Quick and accurate diagnosis of primary cutaneous amyloidosis (PCA) may be difficult because its symptoms are often subtle and nonspecific.

Objective: We sought to review the literature on the roles of various staining methods in the diagnosis of amyloidosis and demonstrate added benefits of using rapid 4,6-diamidino-2-phenylindole (DAPI) staining in the diagnosis of PCA.

Methods: Three groups of cases, namely, PCA, neurodermatitis, and prurigo nodularis, were retrieved from a computerized pathology database for study, and their paraffin-embedded tissue blocks were cut following standard procedures. Read More

Indian J Dermatol Venereol Leprol 2021 Aug 1:1-5. Epub 2021 Aug 1.

Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India.

Background: There are very few population-based studies on the prevalence of eczema among older persons Aims: To estimate the prevalence and types of eczema in those aged 65 years or more in the community and to evaluate the effectiveness of community-based interventions for case finding.

Methods: In the first stage of this cross-sectional survey, trained health workers of a non-governmental organization surveyed the eligible population and identified persons likely to have eczema. In the second stage, dermatologists examined such persons to ascertain the diagnosis. Read More

Allergol Select 2021 23;5:244-250. Epub 2021 Aug 23.

Department of Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg.

It is obvious that social, biogenic, and anthropogenic environmental factors, as well as nutrition contribute to the development and course of atopic eczema. Social deprivation and stress have a negative impact on atopic eczema symptoms, and social change in recent decades has led to a "westernized" lifestyle associated with high prevalence of atopic eczema in industrialized countries. Urbanization leads to an increase in air pollution and a decrease in biodiversity, which negatively affects atopic eczema. Read More

Dermatology 2022 26;238(3):454-463. Epub 2021 Aug 26.

Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Lichen simplex chronicus (LSC) is characterized by localized lichenification and intense itching. It has been reported that the added use of liquid nitrogen cryotherapy (LNC) for LSC has significant efficacy and notable safety. Therefore, we conducted a meta-analysis based on existing randomized controlled trials (RCTs). Read More

Indian Dermatol Online J 2021 Jul-Aug;12(4):590-592. Epub 2021 Jul 14.

Nirvan Skin Clinic, Makarpura Road, Vadodara, Gujarat, India.

Lichen simplex chronicus (LSC) of the vulva is an acquired, persistent, severely itchy dermatosis usually located in easily reachable areas of the body like the extremities, nape of the neck, and genitalia. It also has a strong association with atopy and is said to be initiated and perpetuated by the itch-scratch-itch cycle. Two cases of rugose labia as the sole presentation of LSC of vulva are being presented. Read More

J Cutan Pathol 2022 Feb 25;49(2):123-132. Epub 2021 Aug 25.

University of California San Francisco, San Francisco, California, USA.

Background: Elevated epidermal interleukin (IL)-36 expression distinguishes psoriasis from eczematous dermatitis, but other psoriasiform dermatitides (PDs) have not been thoroughly investigated for IL-36 expression. In this study, we assess the IL-36 staining pattern (IL36-SP) in psoriasis variants and other PDs including lichen simplex chronicus (LSC), prurigo nodularis (PN), lichen planus (LP), tinea, pityriasis rubra pilaris (PRP), mycosis fungoides (MF), pemphigus foliaceus (PF), acute generalized exanthematous pustulosis (AGEP), impetigo (IMP), and syphilis (SY).

Methods: IL-36 immunostaining was performed on 307 cases of psoriasis and various PDs. Read More