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Hautarzt 2021 Jun 11. Epub 2021 Jun 11.

Institut für Umweltmedizin, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, München, Deutschland.

Background: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors.

Aim: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. Read More

Int J Hyperthermia 2021 ;38(1):781-785

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To compare the efficacy and safety of the treatment of vulvar lichen simplex chronicus (VLSC) using high-intensity focused ultrasound (HIFU) at different powers.

Methods: This retrospective study included 152 patients with VLSC. Among these patients, 70 were treated with HIFU at low power (level 2), and 82 were treated at normal power (level 3). Read More

Indian J Dermatol Venereol Leprol 2021 Apr 12:1-6. Epub 2021 Apr 12.

Department of Dermatology, Venereology and Leprosy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Background: Lesions on the external genitalia could be venereal or non-venereal. Non-venereal genital dermatoses are common and may cause considerable anxiety to patients, particularly if noticed after sexual intercourse. However, this aspect has not been studied much till now. Read More

J Cutan Med Surg 2021 Apr 4:12034754211004558. Epub 2021 Apr 4.

Department of Dermatology, Cumming School of Medicine, Calgary, AB, Canada.

There is a paucity of information surrounding dermatologic care for persons experiencing homelessness (PEH). This scoping review aims to map existing literature and provide a summary of the most common cutaneous manifestations among PEH, risk factors for dermatologic disease, describe any reported interventions, as well as identify research gaps for future studies. Search strategies developed for MEDLINE and hand searching yielded 486 articles. Read More

J Eur Acad Dermatol Venereol 2021 Jul 19;35(7):e450-e452. Epub 2021 Mar 19.

Dermatology -IRCCS Policlinico di Sant'Orsola - Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.

Pan Afr Med J 2020 24;37:267. Epub 2020 Nov 24.

Izmir Metropolitan Municipality Esrefpasa Hospital, Izmir, Turkey.

Introduction: Localized Provoked Vulvodynia (LPV) is a gynecological disease that is difficult to manage. Despite the wide spectrum of pathophysiological mechanisms and treatment modalities, there is limited success in the management of this disease. Surgical treatment is usually performed as the last resort. Read More

J Med Case Rep 2021 Feb 17;15(1):80. Epub 2021 Feb 17.

Maducare.inc, Chidicon Medical Center, Premier Medical Associates, The Villages, FL, USA.

Introduction: Lichen simplex chronicus has been defined as a localized skin condition characterized by thickening, hyperpigmentation and accentuated skin markings from chronic itching and from repeated scratching. The affected skin area is usually described as demarcated, and often circumscribed. It has even been defined as a "psychogenic pruritic disorder". Read More

Dermatol Ther 2021 03 17;34(2):e14855. Epub 2021 Feb 17.

Department of Dermatology, Regional Dermatology Training Center, Kilimanjaro Christian Medical University College (KCMUCo), Moshi, Tanzania.

Prurigo nodularis (PN) is a chronic, benign neurodermatitis of unclear etiology characterized by excoriated, intensely pruritic nodules secondary to an intense itch-scratch cycle. PN treatment is still a challenge, and it is frustrating for both dermatologists and patients. The evidence for the effectiveness of a readily available treatment like cryotherapy is limited. Read More

J Clin Aesthet Dermatol 2020 Dec 1;13(12):12-17. Epub 2020 Dec 1.

Drs. Gharib, Mostafa, and Elsayed are with the Dermatology Department, Faculty of Medicine, at Zagazig University in Ash Sharqia Governorate, Egypt.

Botulinum toxin is a neurotoxin produced by the bacterium that causes a flaccid muscle paralysis. It is currently used for aesthetic procedures and to treat focal hyperhidrosis. The botulinum toxin has also been used experimentally in many other dermatological conditions with positive results. Read More

Allergol Select 2021 5;5:1-25. Epub 2021 Jan 5.

Department of Dermatology and Allergy, Charité Universitätsmedizin, Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany.

With the advent of biologicals, more and more therapeutics are available that specifically address specific switch points in the pathomechanism of immunologically dominated diseases. Thus, the focus of diagnostics and therapy (precision medicine) is more on the individual disease characteristics of the individual patient. Regarding the different phenotypes of atopic diseases, severe asthma was the first entity for which biologicals were approved, followed by urticaria, and finally atopic dermatitis and chronic rhinosinusitis with nasal polyps. Read More

Dermatol Ther 2021 03 12;34(2):e14752. Epub 2021 Jan 12.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Exp Dermatol 2021 Mar 9;30(3):319-336. Epub 2021 Jan 9.

Dr. Phillip Frost, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for testing new candidate AD therapeutics and for interrogating AD pathobiology in vivo. In this Viewpoint, we delineate why, unfortunately, none of the currently available so-called "AD" mouse models satisfactorily reflect the clinical complexity of human AD, but imitate more "allergic" or "irriant" contact dermatitis conditions. This limits the predictive value of AD models for clinical outcomes of new tested candidate AD therapeutics and the instructiveness of mouse models for human AD pathophysiology research. Read More

J Eur Acad Dermatol Venereol 2021 Apr 9;35(4):e285-e287. Epub 2020 Dec 9.

Section of Dermatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.

Arch Dermatol Res 2020 Nov 22. Epub 2020 Nov 22.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue NW, Suite 2B-425, Washington, DC, 20037, USA.

The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Read More

Ann Palliat Med 2020 Nov 10;9(6):3757-3765. Epub 2020 Nov 10.

Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Lichen simplex chronicus (LSC) is an acquired chronic dermatosis that is often accompanied by severe paroxysmal pruritus, and its pathogenesis to date is still unclear. Transient receptor potential channel A1 (TRPA1) is a non-selective cation channel. TRPA1 is widely expressed in skin, sensory neurons, and various other tissues, along with various biological functions and activation mechanisms. Read More

Am Fam Physician 2020 11;102(9):550-557

Medstar Health, Washington, DC, USA.

Common benign chronic vulvar conditions include genitourinary syndrome of menopause (formerly called vulvovaginal atrophy), lichen sclerosus, lichen planus, lichen simplex chronicus, and vulvodynia. Genitourinary syndrome of menopause results from the hypoestrogenic state that leads to atrophy of normal vulvar and vaginal tissues. It is typically treated with lubricants, moisturizers, and intravaginal estrogen. Read More

Indian J Sex Transm Dis AIDS 2020 Jan-Jun;41(1):116-118. Epub 2020 Jun 18.

Department of Dermatology, SBKS MI and RC, Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara, Gujarat, India.

Lichen planus (LP) is an inflammatory dermatosis which can affect the skin, nails, and all mucous membranes, including the genitalia. Lichen planus on vulvar keratinized skin can manifest with diverse clinical features, probably due to higher temperature, PH, humidity, and bacterial flora which may modify typical cutaneous features. While lichen planus (LP) may affect the vulva in isolation, it may also be part of generalized outbreak in up to 20% cases. Read More

J Eur Acad Dermatol Venereol 2021 Apr 3;35(4):e259-e261. Epub 2020 Nov 3.

Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Dermatol Ther 2020 11 19;33(6):e14389. Epub 2020 Oct 19.

University of Health Sciences, Erenköy Training and Research Hospital for Psychiatry and Neurological Diseases, Psychiatry, Istanbul, Turkey.

The aim of this study is to evaluate psychiatric comorbidity, temperament and character traits, depression and anxiety levels, and their relation with symptom severity in patients with lichen simplex chronicus (LSC). About 50 patients with LSC were enrolled in the study along with 49 controls. The Structured Clinical Interview for DSM-5 (SCID-5), Temperament and Character Inventory (TCI), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI) were administered to all subjects for psychiatric assessment. Read More

Medicine (Baltimore) 2020 Oct;99(40):e22586

Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Neurodermatitis is a common inflammatory and allergic disease, characterized by itching and lichenification plaque. Some studies have reported cupping therapy (CT) for the treatment of neurodermatitis. However, the effectiveness and safety are still uncertain. Read More

Case Rep Womens Health 2020 Oct 30;28:e00254. Epub 2020 Aug 30.

Department of Obstetrics & Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

A 31-year-old woman, gravida 3 para 1, at 10 weeks of gestation presented to a vulvar specialty clinic with a 6-month history of vulvar pruritus that had not responded to the treatment prescribed by her referring gynecologist. Examination was consistent with vaginitis and vulvar lichen simplex chronicus. Fungal cultures ultimately revealed and . Read More

J Clin Aesthet Dermatol 2020 Jul 1;13(7):32-35. Epub 2020 Jul 1.

Dr. Khattab is with the Faculty of Medicine, Zagazig University in Zagazig, Egypt.

Botulinum toxin (BTX) A has different biological activities, including anti-inflammatory and antipruritic behavior. Studies on humans and animals have shown that BTX is efficient in treating itch caused by histamine, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar avoidance. This study sought to assess the impact of BTX-A in patients with atopic dermatitis using scores of SCORAD and to identify parameters linked to greater improvements. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):157-159

Department of Dermatovenerology, Ljubljana Medical Center, Ljubljana, Slovenia.

Pretibial pruritic papular dermatitis (PPPD) is a clinical entity first described in 2006. The etiology is uncertain; however, gentle chronic rubbing is likely to be the reason for the skin reaction. Pretibial pruritic lesions may reflect many different systemic diseases and dermatoses. Read More

Semin Diagn Pathol 2021 Jan 6;38(1):27-36. Epub 2020 Sep 6.

University of Virginia Health System, Department of Pathology, Charlottesville, VA 22903, United States. Electronic address:

Precursor lesions of vulvar squamous cell carcinoma (VSCC) can be divided into two major biologic and prognostic groups: HPV-associated and HPV-independent VSCC. These two pathways are categorized as usual vulvar intraepithelial neoplasia (uVIN) with progression to basaloid or warty VSCC and differentiated vulvar intraepithelial neoplasia (dVIN) with progression to the more common keratinizing VSCC. While the HPV-dependent pathway to squamous cell carcinoma is well-understood, the development of squamous cell carcinoma from HPV-independent lesions is less clear. Read More

Indian Dermatol Online J 2020 Jul-Aug;11(4):660-661. Epub 2020 Jul 13.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

J Eur Acad Dermatol Venereol 2021 Feb 14;35(2):e159-e160. Epub 2020 Sep 14.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Histopathology 2021 Feb 27;78(3):424-433. Epub 2020 Oct 27.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Aims: Differentiated vulvar intraepithelial neoplasia (dVIN), the precursor lesion to human papillomavirus-independent vulvar squamous cell carcinoma (VSCC), can be difficult to distinguish from vulvar inflammatory dermatoses. Our goal was to determine if p53 could be a useful biomarker for dVIN, by characterizing p53 percentage, intensity and patterns of staining in dVIN and its histological mimics.

Methods And Results: We studied p53 immunohistochemical staining patterns in 16 dVIN cases and 46 vulvar non-neoplastic squamous lesions [12 lichen sclerosus (LS); seven lichen simplex chronicus; three lichen planus (LP); six psoriasis; 13 spongiotic dermatitis (SPO); and five candidiasis]. Read More

Indian Dermatol Online J 2020 May-Jun;11(3):401-403. Epub 2020 May 10.

Department of Dermatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.

Lichen simplex chronicus (LSC) is characterized by lichenification of the skin because of primary excessive scratching. Herein, we present two cases of scalp LSC with a patch showing localized hair loss and paroxysmal severely itching on that area. Dermoscopy examined the presence of broom hair fibers while histopathological examination revealed gear wheel sign, hair shafts split in two (the hamburger sign), and decrease in the size of the sebaceous glands. Read More

Indian Dermatol Online J 2020 May-Jun;11(3):328-332. Epub 2020 May 10.

Department of Dermatology, Venereology and Leprosy, PGIMER, Chandigarh, India.

The COVID-19 pandemic has directly or indirectly affected every human being on this planet. It's impact on the healthcare system has been devastating. The medical fraternity across the world, including India, is facing unprecedented challenges in striving to cope up with this catastrophic outbreak. Read More

Dermatol Ther 2020 11 10;33(6):e14024. Epub 2020 Aug 10.

Department of Dermatology, Kozhikkod Medical College, Kozhikkod, Kerala, India.

This study was aimed to survey the awareness, knowledge, practicing patterns, and attitudes of dermatologists toward psychocutaneous disorders in a South Indian State. The questionnaire-based study was performed from August 1 to October 31, 2019. Study participants included 123 dermatologists. Read More