1,885 results match your criteria Lichen Simplex Chronicus

[The skin microbiome-useful for diagnosis and therapy?]

Hautarzt 2021 Jun 11. Epub 2021 Jun 11.

Institut für Umweltmedizin, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, München, Deutschland.

Background: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors.

Aim: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. Read More

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Comparison of efficacy and safety of high-intensity focused ultrasound at different powers for patients with vulvar lichen simplex chronicus.

Int J Hyperthermia 2021 ;38(1):781-785

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To compare the efficacy and safety of the treatment of vulvar lichen simplex chronicus (VLSC) using high-intensity focused ultrasound (HIFU) at different powers.

Methods: This retrospective study included 152 patients with VLSC. Among these patients, 70 were treated with HIFU at low power (level 2), and 82 were treated at normal power (level 3). Read More

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January 2021

Non-venereal genital dermatoses and their impact on quality of life-A cross-sectional study.

Indian J Dermatol Venereol Leprol 2021 Apr 12:1-6. Epub 2021 Apr 12.

Department of Dermatology, Venereology and Leprosy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Background: Lesions on the external genitalia could be venereal or non-venereal. Non-venereal genital dermatoses are common and may cause considerable anxiety to patients, particularly if noticed after sexual intercourse. However, this aspect has not been studied much till now. Read More

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Understanding Dermatologic Concerns Among Persons Experiencing Homelessness: A Scoping Review and Discussion for Improved Delivery of Care.

J Cutan Med Surg 2021 Apr 4:12034754211004558. Epub 2021 Apr 4.

Department of Dermatology, Cumming School of Medicine, Calgary, AB, Canada.

There is a paucity of information surrounding dermatologic care for persons experiencing homelessness (PEH). This scoping review aims to map existing literature and provide a summary of the most common cutaneous manifestations among PEH, risk factors for dermatologic disease, describe any reported interventions, as well as identify research gaps for future studies. Search strategies developed for MEDLINE and hand searching yielded 486 articles. Read More

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Lichen simplex chronicus of the scalp: dermoscopy and reflectance confocal microscopy features.

J Eur Acad Dermatol Venereol 2021 Jul 19;35(7):e450-e452. Epub 2021 Mar 19.

Dermatology -IRCCS Policlinico di Sant'Orsola - Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.

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The histopathological results of vestibulectomy specimens in localized provoked vulvodynia in Turkey.

Pan Afr Med J 2020 24;37:267. Epub 2020 Nov 24.

Izmir Metropolitan Municipality Esrefpasa Hospital, Izmir, Turkey.

Introduction: Localized Provoked Vulvodynia (LPV) is a gynecological disease that is difficult to manage. Despite the wide spectrum of pathophysiological mechanisms and treatment modalities, there is limited success in the management of this disease. Surgical treatment is usually performed as the last resort. Read More

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February 2021

Scabies-induced lichen simplex chronicus misdiagnosed as psychogenic pruritus: a case report.

J Med Case Rep 2021 Feb 17;15(1):80. Epub 2021 Feb 17.

Maducare.inc, Chidicon Medical Center, Premier Medical Associates, The Villages, FL, USA.

Introduction: Lichen simplex chronicus has been defined as a localized skin condition characterized by thickening, hyperpigmentation and accentuated skin markings from chronic itching and from repeated scratching. The affected skin area is usually described as demarcated, and often circumscribed. It has even been defined as a "psychogenic pruritic disorder". Read More

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February 2021

Prurigo nodularis comparative treatment outcome in patients attending a tertiary hospital in northern Tanzania.

Dermatol Ther 2021 03 17;34(2):e14855. Epub 2021 Feb 17.

Department of Dermatology, Regional Dermatology Training Center, Kilimanjaro Christian Medical University College (KCMUCo), Moshi, Tanzania.

Prurigo nodularis (PN) is a chronic, benign neurodermatitis of unclear etiology characterized by excoriated, intensely pruritic nodules secondary to an intense itch-scratch cycle. PN treatment is still a challenge, and it is frustrating for both dermatologists and patients. The evidence for the effectiveness of a readily available treatment like cryotherapy is limited. Read More

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Evaluation of Botulinum Toxin Type A Injection in the Treatment of Localized Chronic Pruritus.

J Clin Aesthet Dermatol 2020 Dec 1;13(12):12-17. Epub 2020 Dec 1.

Drs. Gharib, Mostafa, and Elsayed are with the Dermatology Department, Faculty of Medicine, at Zagazig University in Ash Sharqia Governorate, Egypt.

Botulinum toxin is a neurotoxin produced by the bacterium that causes a flaccid muscle paralysis. It is currently used for aesthetic procedures and to treat focal hyperhidrosis. The botulinum toxin has also been used experimentally in many other dermatological conditions with positive results. Read More

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December 2020

Biologics for atopic diseases: Indication, side effect management, and new developments.

Allergol Select 2021 5;5:1-25. Epub 2021 Jan 5.

Department of Dermatology and Allergy, Charité Universitätsmedizin, Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany.

With the advent of biologicals, more and more therapeutics are available that specifically address specific switch points in the pathomechanism of immunologically dominated diseases. Thus, the focus of diagnostics and therapy (precision medicine) is more on the individual disease characteristics of the individual patient. Regarding the different phenotypes of atopic diseases, severe asthma was the first entity for which biologicals were approved, followed by urticaria, and finally atopic dermatitis and chronic rhinosinusitis with nasal polyps. Read More

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January 2021

A rare case of lichen simplex chronicus in an adolescent female successfully managed with Crisaborole.

Dermatol Ther 2021 03 12;34(2):e14752. Epub 2021 Jan 12.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

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Mouse models of atopic dermatitis: a critical reappraisal.

Exp Dermatol 2021 Mar 9;30(3):319-336. Epub 2021 Jan 9.

Dr. Phillip Frost, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for testing new candidate AD therapeutics and for interrogating AD pathobiology in vivo. In this Viewpoint, we delineate why, unfortunately, none of the currently available so-called "AD" mouse models satisfactorily reflect the clinical complexity of human AD, but imitate more "allergic" or "irriant" contact dermatitis conditions. This limits the predictive value of AD models for clinical outcomes of new tested candidate AD therapeutics and the instructiveness of mouse models for human AD pathophysiology research. Read More

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Our experience with prurigo nodularis treated with dupilumab.

J Eur Acad Dermatol Venereol 2021 Apr 9;35(4):e285-e287. Epub 2020 Dec 9.

Section of Dermatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.

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What are the highest yielding search strategy terms for systematic reviews in atopic dermatitis? A systematic review.

Arch Dermatol Res 2020 Nov 22. Epub 2020 Nov 22.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue NW, Suite 2B-425, Washington, DC, 20037, USA.

The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Read More

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November 2020

Down-regulated expression of transient receptor potential ankyrin 1 in lichen simplex chronicus.

Ann Palliat Med 2020 Nov 10;9(6):3757-3765. Epub 2020 Nov 10.

Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Lichen simplex chronicus (LSC) is an acquired chronic dermatosis that is often accompanied by severe paroxysmal pruritus, and its pathogenesis to date is still unclear. Transient receptor potential channel A1 (TRPA1) is a non-selective cation channel. TRPA1 is widely expressed in skin, sensory neurons, and various other tissues, along with various biological functions and activation mechanisms. Read More

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November 2020

Common Benign Chronic Vulvar Disorders.

Am Fam Physician 2020 11;102(9):550-557

Medstar Health, Washington, DC, USA.

Common benign chronic vulvar conditions include genitourinary syndrome of menopause (formerly called vulvovaginal atrophy), lichen sclerosus, lichen planus, lichen simplex chronicus, and vulvodynia. Genitourinary syndrome of menopause results from the hypoestrogenic state that leads to atrophy of normal vulvar and vaginal tissues. It is typically treated with lubricants, moisturizers, and intravaginal estrogen. Read More

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November 2020

Hypertrophic lichen planus of the vulva - A missed diagnosis.

Indian J Sex Transm Dis AIDS 2020 Jan-Jun;41(1):116-118. Epub 2020 Jun 18.

Department of Dermatology, SBKS MI and RC, Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara, Gujarat, India.

Lichen planus (LP) is an inflammatory dermatosis which can affect the skin, nails, and all mucous membranes, including the genitalia. Lichen planus on vulvar keratinized skin can manifest with diverse clinical features, probably due to higher temperature, PH, humidity, and bacterial flora which may modify typical cutaneous features. While lichen planus (LP) may affect the vulva in isolation, it may also be part of generalized outbreak in up to 20% cases. Read More

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Langerhans cell histiocytosis mimicking prurigo nodularis.

J Eur Acad Dermatol Venereol 2021 Apr 3;35(4):e259-e261. Epub 2020 Nov 3.

Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

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Psychiatric comorbidity and temperament-character traits of the patients with lichen simplex chronicus: The relation with the symptom severity of the disease.

Dermatol Ther 2020 11 19;33(6):e14389. Epub 2020 Oct 19.

University of Health Sciences, Erenköy Training and Research Hospital for Psychiatry and Neurological Diseases, Psychiatry, Istanbul, Turkey.

The aim of this study is to evaluate psychiatric comorbidity, temperament and character traits, depression and anxiety levels, and their relation with symptom severity in patients with lichen simplex chronicus (LSC). About 50 patients with LSC were enrolled in the study along with 49 controls. The Structured Clinical Interview for DSM-5 (SCID-5), Temperament and Character Inventory (TCI), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI) were administered to all subjects for psychiatric assessment. Read More

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November 2020

Cupping for neurodermatitis: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2020 Oct;99(40):e22586

Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Neurodermatitis is a common inflammatory and allergic disease, characterized by itching and lichenification plaque. Some studies have reported cupping therapy (CT) for the treatment of neurodermatitis. However, the effectiveness and safety are still uncertain. Read More

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October 2020

Eradication of in a pregnant patient: A case report.

M Luann Racher

Case Rep Womens Health 2020 Oct 30;28:e00254. Epub 2020 Aug 30.

Department of Obstetrics & Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

A 31-year-old woman, gravida 3 para 1, at 10 weeks of gestation presented to a vulvar specialty clinic with a 6-month history of vulvar pruritus that had not responded to the treatment prescribed by her referring gynecologist. Examination was consistent with vaginitis and vulvar lichen simplex chronicus. Fungal cultures ultimately revealed and . Read More

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October 2020

Evaluation of Botulinum Toxin A as an Optional Treatment for Atopic Dermatitis.

Fathia M Khattab

J Clin Aesthet Dermatol 2020 Jul 1;13(7):32-35. Epub 2020 Jul 1.

Dr. Khattab is with the Faculty of Medicine, Zagazig University in Zagazig, Egypt.

Botulinum toxin (BTX) A has different biological activities, including anti-inflammatory and antipruritic behavior. Studies on humans and animals have shown that BTX is efficient in treating itch caused by histamine, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar avoidance. This study sought to assess the impact of BTX-A in patients with atopic dermatitis using scores of SCORAD and to identify parameters linked to greater improvements. Read More

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A case report and differential diagnosis of pruritic pretibial skin lesions.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):157-159

Department of Dermatovenerology, Ljubljana Medical Center, Ljubljana, Slovenia.

Pretibial pruritic papular dermatitis (PPPD) is a clinical entity first described in 2006. The etiology is uncertain; however, gentle chronic rubbing is likely to be the reason for the skin reaction. Pretibial pruritic lesions may reflect many different systemic diseases and dermatoses. Read More

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September 2020

Putative precancerous lesions of vulvar squamous cell carcinoma.

Semin Diagn Pathol 2021 Jan 6;38(1):27-36. Epub 2020 Sep 6.

University of Virginia Health System, Department of Pathology, Charlottesville, VA 22903, United States. Electronic address:

Precursor lesions of vulvar squamous cell carcinoma (VSCC) can be divided into two major biologic and prognostic groups: HPV-associated and HPV-independent VSCC. These two pathways are categorized as usual vulvar intraepithelial neoplasia (uVIN) with progression to basaloid or warty VSCC and differentiated vulvar intraepithelial neoplasia (dVIN) with progression to the more common keratinizing VSCC. While the HPV-dependent pathway to squamous cell carcinoma is well-understood, the development of squamous cell carcinoma from HPV-independent lesions is less clear. Read More

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January 2021

A Simple and Effective Therapeutic Approach to Lichen Simplex Chronicus.

Indian Dermatol Online J 2020 Jul-Aug;11(4):660-661. Epub 2020 Jul 13.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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Itchy plaques on trunk and feet in a patient with dark skin: a case of Dystrophic Calcinosis Cutis superimposed on Lichen Simplex Chronicus.

J Eur Acad Dermatol Venereol 2021 Feb 14;35(2):e159-e160. Epub 2020 Sep 14.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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February 2021

Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva.

Histopathology 2021 Feb 27;78(3):424-433. Epub 2020 Oct 27.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Aims: Differentiated vulvar intraepithelial neoplasia (dVIN), the precursor lesion to human papillomavirus-independent vulvar squamous cell carcinoma (VSCC), can be difficult to distinguish from vulvar inflammatory dermatoses. Our goal was to determine if p53 could be a useful biomarker for dVIN, by characterizing p53 percentage, intensity and patterns of staining in dVIN and its histological mimics.

Methods And Results: We studied p53 immunohistochemical staining patterns in 16 dVIN cases and 46 vulvar non-neoplastic squamous lesions [12 lichen sclerosus (LS); seven lichen simplex chronicus; three lichen planus (LP); six psoriasis; 13 spongiotic dermatitis (SPO); and five candidiasis]. Read More

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February 2021

Lichen Simplex Chronicus on the Scalp: Broom Fibers on Dermoscopy; Gear Wheel Sign and Hamburger Sign on Histopathology.

Indian Dermatol Online J 2020 May-Jun;11(3):401-403. Epub 2020 May 10.

Department of Dermatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.

Lichen simplex chronicus (LSC) is characterized by lichenification of the skin because of primary excessive scratching. Herein, we present two cases of scalp LSC with a patch showing localized hair loss and paroxysmal severely itching on that area. Dermoscopy examined the presence of broom hair fibers while histopathological examination revealed gear wheel sign, hair shafts split in two (the hamburger sign), and decrease in the size of the sebaceous glands. Read More

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Impact of COVID-19 Pandemic on Dermatologists and Dermatology Practice.

Indian Dermatol Online J 2020 May-Jun;11(3):328-332. Epub 2020 May 10.

Department of Dermatology, Venereology and Leprosy, PGIMER, Chandigarh, India.

The COVID-19 pandemic has directly or indirectly affected every human being on this planet. It's impact on the healthcare system has been devastating. The medical fraternity across the world, including India, is facing unprecedented challenges in striving to cope up with this catastrophic outbreak. Read More

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Awareness of psychodermatology in Indian dermatologists: A South Indian perspective.

Dermatol Ther 2020 11 10;33(6):e14024. Epub 2020 Aug 10.

Department of Dermatology, Kozhikkod Medical College, Kozhikkod, Kerala, India.

This study was aimed to survey the awareness, knowledge, practicing patterns, and attitudes of dermatologists toward psychocutaneous disorders in a South Indian State. The questionnaire-based study was performed from August 1 to October 31, 2019. Study participants included 123 dermatologists. Read More

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November 2020