Search Our Scientific Publications & Authors

J Eur Acad Dermatol Venereol 2020 Jun 29. Epub 2020 Jun 29.

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.

Background: Chronic inflammatory vulvar diseases can have a huge detrimental impact on patient welfare. A few studies have addressed this issue so far, mainly measuring patients' quality of life or sexual dysfunction.

Objective: To assess the burden of suffering in patients with chronic inflammatory vulvar diseases using the Pictorial Representation of Illness and Self-Measure (PRISM), a visual, non-verbal instrument. Read More

Obstet Gynecol 2020 07;136(1):e1-e14

Vulvar skin disorders include a variety of inflammatory conditions of the vulva that also may affect the extragenital area. Pruritus and pain are two of the most common presenting symptoms in vulvar clinics (). Vulvovaginal symptoms often are chronic and can adversely affect sexual function and sense of well-being. Read More

Obstet Gynecol 2020 Jul;136(1):222-225

Vulvar skin disorders include a variety of inflammatory conditions of the vulva that also may affect the extragenital area. Pruritus and pain are two of the most common presenting symptoms in vulvar clinics (). Vulvovaginal symptoms often are chronic and can adversely affect sexual function and sense of well-being. Read More

Lupus 2020 Jun 26:961203320935169. Epub 2020 Jun 26.

Department of Dermatology, University of São Paulo, Brazil.

Trigeminal trophic syndrome occurs secondary to trigeminal nerve injury, leading to anaesthesia and paraesthesia, with consequent vigorous facial skin manipulation and lesion production, simulating other facial diseases such as ulcerative discoid lupus erythematosus, tumours and other artificially produced lesions. Ulceration and destruction of the ala nasi is a typical feature besides scratching end excoriations in the cutaneous segment affected. In this series, we present the features of five patients with trigeminal trophic syndrome, highlighting possible confusion with cutaneous lupus. Read More

Klin Padiatr 2020 Jun 25. Epub 2020 Jun 25.

Ludwig Boltzmann Institut for Health Technology Assessment, Ludwig Boltzmann Gesellschaft, Vienna, Austria.

Increasing chronic diseases in children and adolescents such as obesity, asthma bronchiale, or mental disorders, result in a growing importance of rehabilitation programs and subsequent program evaluations. We conducted a systematic literature search in 5 databases and provided an overview of methods for evaluating inpatient child and adolescent rehabilitation programs. This included an identification of generic and indication-specific outcomes and standardized measuring instruments. Read More

Ultrasound Med Biol 2020 Jun 7. Epub 2020 Jun 7.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biomedical Chongqing Medical University, Chongqing, China. Electronic address:

The purpose of this study was to investigate the therapeutic effects of focused ultrasound on the expression of notch1, c-fos and transforming growth factor-β3 (TGF-β3) in genital skin of SD rats with vulvar lichen simplex chronicus (LSC). Fifty-six female SD rats with LSC were randomly divided into therapy and sham groups. The therapy group was exposed to focused ultrasound. Read More

Allergol Immunopathol (Madr) 2020 Apr 2. Epub 2020 Apr 2.

Division of Clinical Immunology and Allergy, Faculdade de Medicina da Universidade de São Paulo, Brazil.

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsing eczema and pruritus. Until the development of Dupilumab, a new monoclonal antibody targeting IL-4 and IL-13 receptors, the current treatment of severe cases was based on immunosuppressant agents. Our main goal was to build a case series of five patients with severe atopic dermatitis, who were using immunosuppressive drugs with significant adverse effects and only partially controlled AD, and compare their symptoms, SCORAD index, treatment regimens, total and specific IgE, and blood cell count before and after the introduction of Dupilumab. Read More

Cureus 2020 Feb 25;12(2):e7096. Epub 2020 Feb 25.

Plastic Surgery, Hospital La Luz, Madrid, ESP.

Background Lichen sclerosus is an inflammatory dermatosis of unknown etiology which currently has no cure. Most treatment guidelines recommend the use of ultrapotent topical corticosteroids. However, the relapse rate is usually high. Read More

Head Neck Pathol 2020 Mar 16. Epub 2020 Mar 16.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02215, USA.

Benign alveolar ridge keratosis (BARK), the intraoral counterpart of cutaneous lichen simplex chronicus, is a reactive hyperkeratosis caused by trauma or friction that presents as a poorly demarcated white papule or plaque on the keratinized mucosa of the retromolar pad or alveolar ridge mucosa (often edentulous). This is a clinical and histopathologic analysis of BARK including evaluation of p53 expression in selected cases. One hundred and sixty-seven cases of BARK were identified from 2016 to 2017 and 112 (67. Read More

Arch Dermatol Res 2020 Feb 20. Epub 2020 Feb 20.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Suite 2B-425, 2150 Pennsylvania Avenue NW, Washington, DC, 20037, USA.

Prurigo nodularis (PN) and lichen simplex chronicus (LSC) are debilitating chronic pruritic diseases that can lead to and be exacerbated by psychosocial distress. However, little is known about the mental health (MH) comorbidities of PN/LSC. We sought to evaluate the likelihood and cost-burden of MH comorbidities and emergencies associated with PN/LSC. Read More

Indian J Dermatol 2020 Jan-Feb;65(1):47-49

Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

A 50-year-old woman had suffered from chronic pruritic plaque located on right retroauricular area for around 16 years, which was diagnosed as lichen simplex chronicus. Seventeen years ago, patient had multiple scalded areas distributed throughout the body and underwent autologous skin flap transplantation for the right retroauricular wound. After the wound healed, patient started experiencing paresthesia continuously on the skin grafted area and could not resist scratching. Read More

Acta Dermatovenerol Croat 2019 Dec;27(4):273-274

Assoc. Prof. Halil Tekiner, MD, PhD, Department of the History of Pharmacy and Ethics, Erciyes University School of Pharmacy , 38280 Kayseri, Turkey;

The German dermatologist Paul Gerson Unna (1850-1929) is a prominent figure in the history of medicine for pioneering modern dermatopathology and dermotherapy (Figure 1) (1). Aside from writing extensively on anatomy, histopathology, and treatment of skin diseases, he contributed to medicine in many other ways: he originated the idea of using coated pills to enhance local absorption in the intestine, introduced ammonium bituminosulfonate (ichthyol) and resorcinol into medicine, and described several skin conditions including seborrheic dermatitis. Moreover, in 1881 he established a private clinic in Hamburg, Germany, which became a leading expert center in the diagnosis and treatment of skin disorders, hosting postgraduate physicians from all over the world for training (2). Read More

Nan Fang Yi Ke Da Xue Xue Bao 2019 Dec;39(12):1487-1493

State Key Laboratory of Ultrasound Medical Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.

Objective: To explore the changes of collagen fibrosis in the vulva skin of SD rats with lichen simplex chronicus (LSC) after focused ultrasound therapy and explore the mechanism by which focused ultrasound reduces the recurrence of vulvar LSC.

Methods: Fifty female SD rat models of vulvar LSC were established and randomly divided into the treatment group and the control group (=25) for treatment with focused ultrasound and sham treatment, respectively. Before and after the treatment, vulvar skin tissues were sampled to observe the pathological changes with HE staining and assess the density of collagen fibers using Masson staining. Read More

J Dermatolog Treat 2020 Mar 6:1-9. Epub 2020 Mar 6.

Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Lichen simplex chronicus (LSC) is a disorder characterized by thickened areas of skin from repeated rubbing or scratching. The multifactorial nature of LSC makes management difficult and there are currently no evidence-based guidelines for treatment. We conducted a systematic review of the literature to evaluate treatments for LSC and provide an evidence-based summary of the current treatments as well as highlight novel therapies. Read More

Acta Derm Venereol 2020 Jan 30;100(1):adv00042. Epub 2020 Jan 30.

Department of Medicine of Sensory and Motor Organs, Division of Dermatology, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan.

JAMA Dermatol 2019 Nov 27. Epub 2019 Nov 27.

Associates in Dermatology, Fort Myers, Florida.

Importance: Contact dermatitis in the anogenital area is associated with sleep disturbance and dyspareunia and can profoundly affect quality of life. The literature on anogenital contact dermatitis and culprit allergens is limited. The last large-scale study on common, relevant allergens in patients with anogenital dermatitis was published in 2008. Read More

Am J Dermatopathol 2020 Mar;42(3):191-195

Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL.

Mod Pathol 2020 01 1;33(Suppl 1):107-117. Epub 2019 Nov 1.

Department of Pathology Cleveland Clinic 9500 Euclid Ave L25, Cleveland, OH, 44195, USA.

Inflammatory dermatopathology remains a challenging area for surgical pathologists. Yet every surgical pathologist encounters inflammatory dermatoses as part of routine practice. This review will focus on selected diagnoses that are either commonly encountered in the routine practice of surgical pathology or are critically important. Read More

Indian J Dermatol 2019 Sep-Oct;64(5):360-365

Department of Dermatology and Venereology, Pramukhswami Medical College, Karamsad, Gujarat, India.

Context: There is still a dearth of knowledge regarding the types of dermatoses occurring in postmenopausal women. The common disorders occurring in postmenopausal women and the probable effects of hormonal fluctuations on the skin have to be considered while treating postmenopausal women.

Aims: To study clinical patterns of dermatosis in menopausal women. Read More

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Oct;62(10):1253-1262

Abteilung für Epidemiologie und Gesundheitsmonitoring, FG 28 Soziale Determinanten der Gesundheit, Robert Koch-Institut, General-Pape-Str. 62-66, 12101, Berlin, Deutschland.

Background: Even though 36.5% of children and adolescents living in Germany have a migration background (MB), data on the health of this population is scarce. With population-based data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2, 2014-2017), reliable statements can be given. Read More

Int J Mol Sci 2019 Aug 15;20(16). Epub 2019 Aug 15.

Institute of Precision Medicine, Medical and Life Sciences Faculty, Furtwangen University, Jakob-Kienzle-Strasse 17, 78054 Villingen-Schwenningen, Germany.

Active rebuilding, stabilizing, and maintaining the lipid barrier of the skin is an encouraging disease management and care concept for dry skin, atopic dermatitis (eczema, neurodermatitis), and psoriasis. For decades, corticosteroids have been the mainstay of topical therapy for atopic dermatitis; however, innovations within the scope of basic therapy are rare. In (extremely) dry, irritated, or inflammatory skin, as well as in lesions, an altered (sphingo)lipid profile is present. Read More

J Dermatolog Treat 2019 Aug 29:1-4. Epub 2019 Aug 29.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem , NC , USA.

A transcutaneous electrical nerve stimulation (TENS) unit is an inexpensive, accessible therapeutic device with multiple dermatology-related uses. This review aims to describe the dermatological applications of TENS. PubMed was searched for literature related to TENS in dermatology. Read More

Skin Appendage Disord 2019 Jun 8;5(4):242-245. Epub 2019 Mar 8.

Department of Dermatology, Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia, Rio de Janeiro, Brazil.

Lichen simplex chronicus on the scalp, also known as trichoteiromania, can be difficult to manage, as the therapeutic options are limited to topical or intralesional glucocorticoids. We describe a patient with trichoteiromania, presenting three lichenified pruriginous plaques on different regions of the scalp, associated with fracture and loss of hair shafts. Prior treatment with potent topical glucocorticoids was ineffective. Read More

J Allergy Clin Immunol Pract 2020 Jan 25;8(1):102-112. Epub 2019 Jul 25.

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla.

Allergists/immunologists see a variety of skin disorders, some of which have a known immunologic basis whereas others do not. We review the prevalence, etiology, clinical presentation, and effective and low-cost care of common dermatologic conditions seen in outpatient practices. Conditions discussed include pityriasis alba, seborrheic dermatitis, rosacea, acne, tinea infections, intertrigo, lichen planus, tinea versicolor, lichen simplex chronicus, scabies, pityriasis rosea, keratosis pilaris, and seborrheic keratosis. Read More

Am J Dermatopathol 2020 Jan;42(1):29-34

Faculdade de Medicina, Clínica Universitária de Dermatologia de Lisboa, Universidade de Lisboa, Lisboa, Portugal.

Background: Cutaneous benign angioproliferations can be diagnostically challenging and may mimic vascular tumors. Keratinocytes express vascular endothelial growth factors (VEGFs). We studied the angiogenic factor expression pattern in cutaneous lesions with a distinctive pattern of remarkable dermal angiomatosis underlying prurigo-like epidermal changes. Read More

Surg Pathol Clin 2019 Jun 5;12(2):249-261. Epub 2019 Apr 5.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, MCN C-3306A, 1161 21st Avenue South, Nashville, TN 37232-2582, USA. Electronic address:

The pathogenesis of vulvar squamous neoplasia has 2 pathways: human papillomavirus (HPV)-dependent and HPV-independent. The HPV-dependent pathway in the vulva follows the same progression as HPV-dependent lesions elsewhere in the gynecologic tract-HPV infection results in high-grade squamous intraepithelial lesion with subsequent progression to basaloid squamous cell carcinoma. The HPV-independent pathway is more complex, with a variety of precursor lesions and molecular alterations. Read More

Clin Exp Dermatol 2020 Jan 3;45(1):30-35. Epub 2019 Jul 3.

Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC).

Aim: To investigate if abnormal expression of the co-stimulatory molecule B7-H3 in LSC is associated with Langerhans cell (LC) expansion.

Methods: We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7-H3 and interleukin (IL)-6 was significantly different. Read More

Clin Exp Dermatol 2020 Mar 3;45(2):232-234. Epub 2019 May 3.

St John's Institute of Dermatology, London, UK.

Skin Appendage Disord 2019 Apr 16;5(3):193-195. Epub 2018 Nov 16.

Department of Dermatology, Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil.

Turk J Med Sci 2019 Apr 18;49(2):595-603. Epub 2019 Apr 18.

Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders

Materials And Methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Read More

Dermatol Ther 2019 05 29;32(3):e12906. Epub 2019 Apr 29.

Department of Dermatology, Laboratory research Genodermatosis and Cancers, LR12SP03, Habib Thameur Hospital, Tunis, Tunisia.

Arch Pathol Lab Med 2019 06 28;143(6):768-771. Epub 2018 Dec 28.

From the Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York.

Differentiated-type vulvar intraepithelial neoplasia (dVIN) is a non-human papilloma virus (HPV)-related precursor lesion to vulvar squamous carcinoma. The terminology has only become recognized clinically and histopathologically in recent years despite being described more than 50 years ago. As opposed to the HPV-related VIN (uVIN), dVIN has different features of histomorphology, risk of progression, and molecular pathogenesis. Read More

BMC Dermatol 2018 12 4;18(1):11. Epub 2018 Dec 4.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology laboratory, Mahosot Hospital, Vientiane, Laos.

Background: Skin diseases are common and often have an impact on an individual's health-related quality of life. In rural communities where access to healthcare may be limited and individuals rely on farming for food and income, the impact of skin diseases may be greater. The objectives for this study were to perform an assessment of skin disease prevalence in a rural village in Laos and assess the associated impact of any skin disease found using the Dermatology Life Quality Index (DLQI). Read More

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

Dermatol Clin 2018 Oct;36(4):451-461

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Via L. Ariosto 35, Ferrara 44121, Italy.

Diagnosis of genital inflammatory disorders may be difficult for several reasons, such as their similar appearance, possible misdiagnosis with infectious and malignant conditions, and peculiar anatomic conditions that may lead to modification of clinical features. Dermoscopy could be included as a part of the clinical inspection of genital diseases to support diagnosis, as well as to ideally avoid unnecessary invasive investigation. Practical guidance for the use of dermoscopy in the assessment of the main inflammatory genital diseases is provided, namely for lichen sclerosus, lichen planus, psoriasis, lichen simplex chronicus, and plasma cell mucositis. Read More

J Am Acad Dermatol 2018 Dec 17;79(6):e105-e106. Epub 2018 Jul 17.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. Electronic address:

Pediatr Dermatol 2018 Sep 26;35(5):560-565. Epub 2018 Jun 26.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

The most common causes of chronic nocturnal itching in children are atopic dermatitis and psoriasis, with lichen simplex chronicus and prurigo nodularis contributing to lesser degrees. Despite the prevalence of nocturnal itching, its pathophysiology remains poorly understood. The most troubling consequence of itching at night is poor quality of sleep. Read More

Dermatol Clin 2018 Jul 26;36(3):225-243. Epub 2018 Apr 26.

Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:

Vulvar pruritus is a common complaint among young girls and women presenting to primary care physicians, gynecologists, and dermatologists. Female genital itch is especially disruptive because of its interference with sexual function and intimacy. Causes of vulvar itch are vast and may be inflammatory, environmental, neoplastic, or infectious, often with several causes coexisting simultaneously. Read More

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

Int J Gynecol Pathol 2019 Mar;38(2):175-182

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.C.W., C.P.C., M.R.N.) Stanford University Hospital, Palo Alto, California (E.Y.) Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium (M.H.) Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France (T.G., M.T.).

High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC). Read More

Cutis 2018 Mar;101(3):205-206

Department of Dermatology, McGovern Medical School, University of Texas, Houston, USA.

Terra firma-forme dermatosis (TFFD) is a benign and likely underdiagnosed disorder with relatively few reports in the literature. A 46-year-old woman presented to our clinic with a 3-year history of linear TFFD extending from the upper sacrum to the midline upper back. It initially was thought to be acanthosis nigricans or lichen simplex chronicus, and a topical steroid cream was applied without success. Read More

An Bras Dermatol 2018 Jan-Feb;93(1):108-110

Thychology Outpatient Division at Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.

Lichen simplex chronicus is a skin disease that mostly affects female patients, with a peak incidence between ages 35 and 50 years. On the scalp, it appears as a single or multiple oval lesions, showing scaling and hair shaft loss or breakage. An important dermoscopic feature of the disease are the "broom fibers. Read More

Skinmed 2018;16(1):74-75. Epub 2018 Feb 1.

Division of Dermatology, Department of Medicine and Department of Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;

A 75-year-old man had been monitoring his glucose using a blood glucose monitoring system at the same body site for at least 20 years (>7300 needlesticks). The asymptomatic skin lesion had been present for many years. He used the same site because it hurt less than the fingers and bled well. Read More

Hautarzt 2018 Mar;69(3):217-224

Abteilung für Immundermatologie und experimentelle Allergologie, Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

In severe cases of atopic dermatitis (AD) systemic treatment is indicated. So far, cyclosporine and systemic glucocorticosteroids represented the only systemic treatment options approved for the indications of AD in Germany; however, from clinical practice there is increasing evidence for beneficial therapeutic effects in AD by other immunosuppressive or immunomodulatory substances, such as mycophenolate, methotrexate, alitretinoin and ustekinumab. Beyond this, ongoing research activities focus on a better understanding of genetic and immunological aspects of this chronic inflammatory skin disease. Read More

Hautarzt 2018 Mar;69(3):225-231

Institut für Medizinische Psychologie, Justus-Liebig-Universität Gießen, Klinikstr. 29, 35392, Gießen, Deutschland.

Atopic dermatitis (AD) represents a chronic inflammatory skin disease showing a 1-year prevalence of 2-3% during adulthood. In a national randomized, controlled multicenter study initiated by the "Arbeitsgemeinschaft Neurodermitisschulung im Erwachsenenalter" (ARNE, Working Group on Educational Training for Adults with Atopic Dermatitis) a program for structured patient education conducted by a multiprofessional team was developed and evaluated. At 1‑year follow-up, coping behavior with respect to itch (assessed by the "Juckreiz-Kognitions-Fragebogen", p < 0. Read More

Mod Pathol 2018 07 13;31(7):1131-1140. Epub 2018 Feb 13.

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.

The two main precursors of vulvar squamous cell carcinoma, usual and differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, pathogenesis, and natural history. Usual type VIN is often associated with high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor that shows increased expression in several types of human malignancies including breast and bladder carcinomas. Read More