16,902 results match your criteria Lichen Simplex Chronicus


Evaluation of the Serum Levels of Galectin-3 in Patients with Oral Lichen Planus Disease.

Oral Dis 2018 Dec 6. Epub 2018 Dec 6.

Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Galectin-3, a member of beta-galactoside-binding proteins, can be found in cytoplasm and nucleus as well as extracellularly in various tissues and involved in many physiological and pathological processes. We aimed to measure the serum levels of galectin-3 in oral lichen planus (OLP) disease and compare the result with that observed in healthy ones.

Materials And Methods: In this cross-sectional study, the serum levels of galectin-3 were measured in 56 healthy individuals and 53 pathologically proven OLP patients including those with atrophic/erosive (33 cases) or reticular (20 cases) lesions, using enzyme-linked immunosorbent assay (ELISA). Read More

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December 2018
1 Read

Association of Vulvar Melanoma with Lichen Sclerosus.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Turku University Hospital, PO Box 52, FIN-20521 Turku, Finland.

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December 2018
1 Read

Lichen-associated bacterium, a novel bioresource of polyhydroxyalkanoate (PHA) production and simultaneous degradation of naphthalene and anthracene.

J Microbiol Biotechnol 2018 Nov 16. Epub 2018 Nov 16.

Korean Lichen Research Institute, Sunchon National University, Suncheon, Republic of Korea.

Lichens are generally known as self-sufficient symbiotic life-form between fungus and algae/cyanobacteria, also provide shelter for a wide range of beneficial bacteria. Besides, bacterial derived biodegradable polyhydroxyalkanoate (PHA) is currently grabbing the attention of many researchers as a promising alternative of non-degradable plastics. This study was conducted to develop a new method of PHA production using unexplored lichen-associated bacteria, which can simultaneously degrade two ubiquitous industrial toxins, anthracene and naphthalene. Read More

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November 2018
1 Read

Image Gallery: Dermoscopy of lichen amyloidosis.

Br J Dermatol 2018 Dec;179(6):e231

Dermatology Unit, University of Campania, Nuovo Policlinico (Edificio 9C), Via Pansini 5, 80131, Naples, Italy.

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December 2018

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: a randomized controlled trial.

Int J Dent Hyg 2018 Dec 2. Epub 2018 Dec 2.

Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.

Objectives: The aim of this randomized, parallel-design, clinical trial was to investigate the effectiveness of an intensive plaque control program with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients.

Methods: A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group. Both groups were enrolled in an intensive control program comprising supragingival scaling and polishing, and brush-specific instructions for a period of 8 weeks. Read More

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December 2018
1 Read

Pigmented skin lesions displaying regression features: dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Methods: Observational retrospective study. Read More

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December 2018
3 Reads

Brown Shadow in Lichen Nitidus: A Dermoscopic Marker!

Indian Dermatol Online J 2018 Nov-Dec;9(6):479-480

DNB, Consultant, Rita Skin Foundation, Kolkata, West Bengal, India.

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December 2018

Contrasting Symbiotic Patterns in Two Closely Related Lineages of Trimembered Lichens of the Genus .

Front Microbiol 2018 16;9:2770. Epub 2018 Nov 16.

Department of Biology, Duke University, Durham, NC, United States.

Species circumscription is key to the characterization of patterns of specificity in symbiotic systems at a macroevolutionary scale. Here, a worldwide phylogenetic framework was used to assess the biodiversity and symbiotic patterns of association among partners in trimembered lichens from the genus , section . We sequenced six loci of the main fungal partner and performed species discovery and validation analyses to establish putative species boundaries. Read More

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November 2018

Analysis of Immunologic Function Changes in Lichen Planus After Clinical Treatment.

Med Sci Monit 2018 Dec 2;24:8716-8721. Epub 2018 Dec 2.

Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, China (mainland).

BACKGROUND Lichen planus (LP) is a common chronic superficial skin lesion that causes chronic or sub-acute inflammatory disorders. LP can affect the oral cavity, skin, mucous membrane, and other body parts, and features include repeat attacks and long duration, leading to lower quality of life. This study aimed to analyze the changes of immunologic function before and after treatment of LP. Read More

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December 2018
1 Read

[Lichen striatus].

An Pediatr (Barc) 2018 Nov 28. Epub 2018 Nov 28.

Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital Clínico San Cecilio, Granada, España.

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November 2018

Notch dysregulation and HS: let's talk about Numb.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

We read with great interest the article by J. W. Frew regarding Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Diseases. Read More

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December 2018
2 Reads

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies.

Medicina (Kaunas) 2018 Dec 3;54(6). Epub 2018 Dec 3.

Oral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. Read More

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December 2018

Anogenital Verrucous Carcinoma-A case report.

Int J Surg Case Rep 2018 Nov 27;54:7-9. Epub 2018 Nov 27.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Introduction: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence.

Presentation Of Case: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. Read More

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November 2018
2 Reads

Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development.

Arch Dermatol Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, Kyorin University School of Medicine, 6-20-2, Shinkawa Mitaka, Tokyo, 181-8611, Japan.

No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), which allows accurate quantification of individual sweat glands/ducts actively delivering sweat in a well-defined location, to evaluate sweating disturbance in LP lesions. Read More

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December 2018
1 Read

Hydrolytic Capabilities as a Key to Environmental Success: Chitinolytic and Cellulolytic From Acidic Sub-arctic Soils and Boreal Peatlands.

Front Microbiol 2018 19;9:2775. Epub 2018 Nov 19.

Winogradsky Institute of Microbiology, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.

Members of the are among the most efficient colonizers of acidic terrestrial habitats but the key traits underlying their environmental fitness remain to be understood. We analyzed indigenous assemblages of in a lichen-covered acidic (pH 4.1) soil of forested tundra dominated by uncultivated members of subdivision 1. Read More

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November 2018

Proapoptotic and Antimigratory Effects of and on Colon Cancer Cell Lines.

Food Technol Biotechnol 2018 Sep;56(3):421-430

Department for Biology and Ecology, Faculty of Science, Radoja Domanovića 12, RS-34000 Kragujevac, Serbia.

The aim of this study is to investigate cytotoxic, proapoptotic, antimigratory and pro-antioxidant effects of methanol, acetone and ethyl acetate extracts of lichens and on colorectal cancer (HCT-116 and SW-480) cell lines. We compared the cytotoxic effects on colorectal cancer cells with the effects obtained from normal human fibroblast (MRC-5) cell line. Tetrazolium (MTT) test evaluated the cytotoxic effects, Transwell assay evaluated cell migration, acridine orange/ethidium bromide (AO/EB) fluorescent method followed the apoptosis, while prooxidant/antioxidant effects were determined spectrophotometrically through concentration of redox parameters. Read More

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September 2018
1 Read

Evaluation of Serum Desmoglein 1 and Desmoglein 3 in Oral Erosive Lichen Planus before and after Topical Application of Tacrolimus.

J Contemp Dent Pract 2018 Oct 1;19(10):1204-1213. Epub 2018 Oct 1.

Department of Oral Surgery, Maxillofacial and Diagnostic Science, College of Dentistry, Qassim University, KSA.

Aim: The current study will attempt to throw light on the role of desmoglein 1 and desmoglein 3 in the pathogenesis of erosive lichen planus and their response to topical application of tacrolimus.

Materials And Methods: Twenty patients with erosive oral lichen planus received tacrolimus ointment three times daily for eight weeks. Assessments using the clinical score and a visual analog scale were recorded at each visit. Read More

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October 2018
1 Read

Oral lichen-planus-associated fibroblasts acquire myofibroblast characteristics and secrete pro-inflammatory cytokines in response to Porphyromonas gingivalis lipopolysaccharide stimulation.

BMC Oral Health 2018 Nov 29;18(1):197. Epub 2018 Nov 29.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.

Background: Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease in which comprehensive inflammation-related cytokines are involved. These cytokines are commonly produced by immune cells and specific nonimmune cells including keratinocytes, endothelial cells and fibroblasts. This raises the question of whether fibroblasts in OLP lesions contribute to the inflammatory process upon inflammatory simulation. Read More

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November 2018
1 Read

Labial adhesions in postmenopausal women: presentation and management.

Int Urogynecol J 2018 Nov 28. Epub 2018 Nov 28.

Department of Urogynaecology, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore, 229899, Singapore.

Labial adhesion is defined as complete or partial fusion of the labia minora in the midline through flimsy or dense adhesions. It may be congenital or acquired. Acquired cases are mainly seen in oestrogen deficiency states in prepubertal girls and postmenopausal women. Read More

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November 2018

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, University of California, Irvine.

Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4. Read More

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November 2018
3 Reads

Surgical management of genitourinary lichen sclerosus et atrophicus in boys in England: A 10-year review of practices and outcomes.

J Pediatr Urol 2018 Mar 29. Epub 2018 Mar 29.

Alder Hey Children's Hospital, Liverpool, UK. Electronic address:

Introduction: Circumcision has long been the mainstay of management for genitourinary lichen sclerosus et atrophicus (LS); however, there has been growing interest in surgical techniques that preserve the foreskin.

Objective: The aim of this study was to assess population-based surgical management of LS in England and determine surgical outcomes.

Study Design: Cases of LS treated in English NHS trusts (2002-2011) were extracted from the Hospital Episode Statistics (HES) Database. Read More

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Vitamin D in Nature: A Product of Synthesis and/or Degradation of Cell Membrane Components.

Authors:
H Göring

Biochemistry (Mosc) 2018 Nov;83(11):1350-1357

Göring Consulting, Berlin, 12555, Germany.

The review discusses the data on vitamin D accumulation in animals, plants, and other organisms. 7-Dehydrocholesterol (7-DHC) and ergosterol are considered to be the only true precursors of vitamin D, although even vitamin D (ergocalciferol) is not fully comparable to vitamin D (cholecalciferol) in regard to their functions. These precursors are converted by UV radiation into the corresponding D vitamins. Read More

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November 2018

Soil moisture dynamics under two rainfall frequency treatments drive early spring CO gas exchange of lichen-dominated biocrusts in central Spain.

PeerJ 2018 16;6:e5904. Epub 2018 Nov 16.

Freie Universität Berlin, Department of Biodiversity/Theoretical Ecology, Institute of Biology, Berlin, Germany.

Background: Biocrusts, communities dominated by mosses, lichens, cyanobacteria, and other microorganisms, largely affect the carbon cycle of drylands. As poikilohydric organisms, their activity time is often limited to short hydration events. The photosynthetic and respiratory response of biocrusts to hydration events is not only determined by the overall amount of available water, but also by the frequency and size of individual rainfall pulses. Read More

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November 2018
2 Reads

Differentiation of pityriasis rubra pilaris from plaque psoriasis by dermoscopy.

Dermatol Pract Concept 2018 Oct 31;8(4):299-302. Epub 2018 Oct 31.

Department of Skin & VD, Patna Medical College and Hospital, Patna, Bihar, India.

Background: Diagnosing and differentiating pityriasis rubra pilaris (PRP) from other disorders can be a challenging task. Although histopathology remains the gold standard, it may not be feasible at times, especially in children. Being noninvasive, dermoscopy can be of great diagnostic importance in such a scenario. Read More

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October 2018
1 Read

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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October 2018
2 Reads

Nitrogen-Fixing Bacteria Associated with Cyanolichens and Chlorolichens.

Molecules 2018 Nov 25;23(12). Epub 2018 Nov 25.

Laboratory of Microbial Ecology, Department of Ecological Sciences, Faculty of Sciences, Universidad de Chile, Santiago 7800003, Chile.

Lichens have been extensively studied and described; however, recent evidence suggests that members of the bacterial community associated with them could contribute new functions to the symbiotic interaction. In this work, we compare the nitrogen-fixing guild associated with bipartite terricolous lichens with different types of photobiont: cyanolichens and chlorolichens. Since cyanobacteria contribute nitrogen to the symbiosis, we propose that chlorolichens have more diverse bacteria with the ability to fix nitrogen compared to cyanolichens. Read More

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November 2018
1 Read

Antimicrobial Activity of Divaricatic Acid Isolated from the Lichen against Methicillin-Resistant .

Molecules 2018 Nov 23;23(12). Epub 2018 Nov 23.

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.

One hundred and seventy seven acetone extracts of lichen and 258 ethyl acetate extracts of cultured lichen-forming fungi (LFF) were screened for antimicrobial activity against and using a disk diffusion method. Divaricatic acid was isolated from and identified by LC-MS, ¹H-, C- and DEPT-NMR. Purified divaricatic acid was effective against Gram + bacteria, such as , , , and , with the minimum inhibitory concentration (MIC) values ranging from 7. Read More

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November 2018
2 Reads

Development of a colorimetric PNGase activity assay.

Carbohydr Res 2018 Nov 16;472:58-64. Epub 2018 Nov 16.

Glycomics and Glycan Bioengineering Research Center (GGBRC), College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing, 210095, China. Electronic address:

PNGases are crucial targets and valuable tools in analyzing asparagine-linked carbohydrate moieties (N-glycans) of glycoproteins. Activity tests of PNGases have been little improved since their discovery four decades ago, and still rely on observing deglycosylation patterns of glycoproteins or glycopeptides using SDS-PAGE or HPLC analysis. These techniques cannot be easily adapted for automated sampling and high-throughput procedures. Read More

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November 2018
2 Reads

Planctomycetes in boreal and subarctic wetlands: diversity patterns and potential ecological functions.

FEMS Microbiol Ecol 2019 Feb;95(2)

Winogradsky Institute of Microbiology, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Leninsky prospect 33-2, Russia.

Members of the phylum Planctomycetes are common inhabitants of boreal Sphagnum peat bogs and lichen-dominated tundra wetlands. These bacteria colonize both oxic and anoxic peat layers and reach the population size of 107 cells per gram of wet peat. The 16S rRNA gene sequences from planctomycetes comprise 5%-22% of total 16S rRNA gene reads retrieved from peat samples. Read More

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February 2019

sp. nov. (Trebouxiophyceae, Chlorophyta), a lichen epiphytic alga from Fildes Peninsula, Antarctica.

PhytoKeys 2018 2(110):39-50. Epub 2018 Nov 2.

School of Life Science and Technology, Harbin Institute of Technology, 2 Yikuang Street, Nangang Distinct, Harbin, 150080, China Harbin Institute of Technology Harbin China.

A single-celled green alga Shunan Cao & Qiming Zhou, , isolated from a specimen of Antarctic lichen (Vahl) Gray, is described and illustrated based on a comprehensive investigation of morphology, ultrastructure, ecology and phylogeny. The cells of are ovoid to long ellipsoidal and measured 3-5 µm × 6-12 µm. The new species has distinct ITS rDNA and SSU rDNA sequences and differs from the phylogenetic closely related species , and in cell size, distribution and habitat. Read More

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November 2018

Frontal fibrosing alopecia: a case series of 65 patients seen in a single Italian center.

J Eur Acad Dermatol Venereol 2018 Nov 25. Epub 2018 Nov 25.

Dermatology, Department of Specialized, Diagnostic and Experimental Medicine, University of Bologna, Italy.

Background: Frontal fibrosing alopecia (FFA) is increasing in prevalence worldwide and several series from different countries have been published, in order to detect possible causes of the disease outbreak.

Objective: To analyze the epidemiological, clinical and trichoscopic features of FFA seen in an Italian Dermatology Unit.

Methods: Clinical, trichoscopy, histopathology and medical details of all patients were compared with literature and general population data. Read More

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November 2018
3 Reads

Future research priorities for lichen sclerosus - results of a James Lind Alliance Priority Setting Partnership.

Br J Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Centre of Evidence Based Dermatology, University of Nottingham, UK.

Lichen sclerosus (LS) is a chronic, inflammatory genital skin condition affecting men, women and children. Long-term complications include loss of normal anatomy from scarring, and malignant transformation. Uncertainties exist about the cause, diagnosis and management of LS. Read More

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November 2018
6 Reads

IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus.

Arch Oral Biol 2018 Nov 17;98:115-121. Epub 2018 Nov 17.

Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China. Electronic address:

Objective: The aim of the present study was to investigate the correlation between IL-25 expression and disease severity, and the potential immunoregulatory role of IL-25 expression in oral lichen planus (OLP).

Materials And Methods: The oral mucosal tissue samples obtained from OLP patients and healthy controls (HCs) were analyzed for IL-25 expression by real-time quantitative PCR (qPCR) and immunohistochemistry. Recombinant IL-25 was used to stimulate OLP patient-derived CD4 + T cells, and then IL-4 secretion and mRNA expression were evaluated by ELISA and qPCR, respectively. Read More

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November 2018
5 Reads

Lichen sclerosus et atrophicus diagnosed in a child accompanied with local periodontal attachment loss and maxillary deficiency: A rare case report.

J Dermatol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

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November 2018
1 Read

The Expression of CXCL10/CXCR3 and Effect of the Axis on the Function of T Lymphocyte Involved in Oral Lichen Planus.

Inflammation 2018 Nov 22. Epub 2018 Nov 22.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.

The etiology of oral lichen planus (OLP) is still not clear. The purpose of this study was to explore the role of CXC chemokine receptor 3(CXCR3) and its ligand CXC motif chemokine 10(CXCL10) in the pathogenesis of OLP. We examined the expression of CXCR3 and CXCL10 in OLP patients and healthy controls by quantitative real-time PCR, Western blotting, ELISAs, and immunohistochemistry, respectively. Read More

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November 2018
1 Read

Facial and Extrafacial Lesions in an Ethnically Diverse Series of 91 Patients with Frontal Fibrosing Alopecia Followed at a Single Center.

Dermatology 2018 Nov 22:1-8. Epub 2018 Nov 22.

Background: Various facial and extrafacial lesions have been reported in frontal fibrosing alopecia (FFA). Facial papules have been associated with worse prognosis.

Objectives: We sought to detect the prevalence of facial and extrafacial lesions and to analyze their relation to demographic and clinical variables in a large and ethnically diverse series of patients with FFA. Read More

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November 2018
1 Read

CHRONIC ULCERATIVE STOMATITIS: a comprehensive review and proposal for diagnostic criteria.

Oral Dis 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Medical University of Warsaw, Poland.

Chronic ulcerative stomatitis (CUS) is an immune-mediated disorder characterized by oral erosions and ulcers usually refractory to conventional treatments. The disease often involves middle-aged and older women with painful lesions sometimes resembling those of erosive oral lichen planus (OLP). The most affected sites are the buccal mucosa, the gingiva and the tongue, but the skin is involved in 22. Read More

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November 2018
6 Reads

Soft Tissue Disorders of the Mouth.

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

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February 2019
6 Reads

Transcriptome analysis of hopanoid deficient mutant of Rhodopseuodomonas palustris TIE-1.

Microbiol Res 2019 Jan 29;218:108-117. Epub 2018 Oct 29.

Department of Plant Sciences, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad, 500 046, India. Electronic address:

All three domains of life have an ordered plasma membrane which is pivotal in the selective fitness of primitive life. Like cholesterol in eukaryotes, hopanoids are important in bacteria to modulate membrane order. Hopanoids are pentacyclic triterpenoid lipids biosynthesised in many eubacteria, few ferns and lichens. Read More

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January 2019
2 Reads

[Chemical and pharmacological progress on usnic acid and its derivatives].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(19):3811-3821

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.

Usnic acid and its derivatives, a group of organic molecules with great importance, are characteristic to lichens, possessing pharmacological activities such as anti-virus, anti-bacteria, anti-humor, anti-inflammatory, analgesic, and anaesthetic effects. Many of them have been widely used as medicine, but also bring side effects such as dermatitis and liver damages. In the past decades, great efforts by isolation, organic synthesis, and structure modification methods were put on discovery of UA derivatives with higher biological activities or less side effects. Read More

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October 2018

Orthologous peramine and pyrrolopyrazine-producing biosynthetic gene clusters in Metarhizium rileyi, Metarhizium majus and Cladonia grayi.

Environ Microbiol 2018 Nov 19. Epub 2018 Nov 19.

Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand.

Peramine is a non-ribosomal peptide-derived pyrrolopyrazine (PPZ)-containing molecule with anti-insect properties. Peramine is known to be produced by fungi from genus Epichloë, which form mutualistic endophytic associations with cool-season grass hosts. Peramine biosynthesis has been proposed to require only the two-module non-ribosomal peptide synthetase (NRPS) peramine synthetase (PerA), which is encoded by the 8. Read More

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November 2018
4 Reads

Anti-Inflammatory Activity of Lobaric Acid via Suppressing NF-κB/MAPK Pathways or NLRP3 Inflammasome Activation.

Planta Med 2018 Nov 16. Epub 2018 Nov 16.

School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Lobaric acid (LA) is a constituent of the lichen . LA has multiple biological activities, including antibacterial and antioxidant ones. The purpose of this study was to investigate the effect of LA and its mechanism on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. Read More

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November 2018
3 Reads

Short-term Impacts of Tillage and Fertilizer Treatments on Soil and Root Borne Nematodes and Maize Yield in a Fine Textured .

J Nematol 2018 ;50(3):329-342

Department of Research and Specialist Services, P.O. Box CY550, Causeway, Harare, Zimbabwe.

Conservation agriculture (CA) based on the principles of minimum soil disturbance, crop residue retention, and crop rotation has been the focus of intensive research in recent years. A study was carried out to determine the effects of tillage and fertilizer on the population densities of plant-parasitic nematodes in maize. Three tillage regimes, (i) basin planting, (ii) rip line seeding, and (iii) conventional tillage, were combined with four fertilizer regimes: (i) no-fertilizer, (ii) low fertilizer rate, (iii) medium fertilizer rate, and (iv) high fertilizer rate. Read More

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January 2018
7 Reads

Treatment of Cutaneous Lichen Planus (Part 2): A Review of Systemic Therapies.

J Dermatolog Treat 2018 Nov 17:1-40. Epub 2018 Nov 17.

b Department of Dermatology , University of KwaZulu-Natal & Nelson Mandela School of Medicine , Durban , South Africa.

Background: Although numerous medications are available for the treatment of cutaneous lichen planus (CLP), recurrence is common and there is a lack of evidence of efficacy of many treatment options. Part 1 reviewed consolidated evidence from topical therapies and phototherapy. In Part 2, all systemic treatments are assessed. Read More

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November 2018
3 Reads

Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study.

Australas J Dermatol 2018 Nov 18. Epub 2018 Nov 18.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.

Background/objectives: Lichen planus-like keratoses (LPLK) are benign skin lesions that can mimic malignancy; the clinical and dermoscopic features distinguishing lichen planus-like keratoses from skin tumors have not been extensively studied. The objective of this study was to identify dermoscopic features that may prevent unnecessary biopsies of lichen planus-like keratoses.

Methods: Retrospective, observational study of biopsied skin lesions. Read More

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November 2018
4 Reads

Selecting lichen functional traits as ecological indicators of the effects of urban environment.

Sci Total Environ 2018 Nov 10;654:705-713. Epub 2018 Nov 10.

Graduate Program in Ecology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, CEP 90650-001 Porto Alegre, Rio Grande do Sul, Brazil.

Air pollution and the urban heat island effect are known to directly affect ecosystems in urban areas. Lichens, which are widely known as good ecological indicators of air quality and of climatic conditions, can be a valuable tool to monitor environmental changes in urban environments. The objective of this work was to select lichen functional traits and functional groups that can be used as ecological indicators of the effects of urbanization, with emphasis in the Southern subtropics, where this had never been done. Read More

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November 2018

A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: A case series.

Photodiagnosis Photodyn Ther 2018 Nov 14. Epub 2018 Nov 14.

Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269, Białystok, Poland; Dental Practice, ul. Waszyngtona 1/34, 15-269, Białystok, Poland.

Background: The aim of the study was to clinically evaluate the efficacy of photodynamic therapy in treatment of reticular oral lichen planus (OLP).

Methods: Fifty patients aged 26-84, with 124 OLP lesions in total, underwent photodynamic therapy (PDT) mediated with topically applied 5% 5-aminolevulinic acid. ALA was activated by a custom-made diode lamp with a high-power LED emitting light at 630 nm and 300 mW delivered through an optical fiber probe. Read More

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November 2018
6 Reads

Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

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November 2018
3 Reads