1,819 results match your criteria Lichen Simplex Chronicus


The efficacy and safety of targeted narrowband UVB therapy: a retrospective cohort study

Turk J Med Sci 2019 Apr 18;49(2):595-603. Epub 2019 Apr 18.

Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders

Materials And Methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1810-110DOI Listing
April 2019
1 Read

The use of 308 nm excimer lamp as a novel treatment for vulvar lichen simplex chronicus.

Dermatol Ther 2019 Apr 9:e12906. Epub 2019 Apr 9.

Dermatology department, Habib Thameur Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1111/dth.12906DOI Listing

Differentiated Vulvar Intraepithelial Neoplasia: A Brief Review of Clinicopathologic Features.

Arch Pathol Lab Med 2018 Dec 28. Epub 2018 Dec 28.

From the Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York.

Differentiated-type vulvar intraepithelial neoplasia (dVIN) is a non-human papilloma virus (HPV)-related precursor lesion to vulvar squamous carcinoma. The terminology has only become recognized clinically and histopathologically in recent years despite being described more than 50 years ago. As opposed to the HPV-related VIN (uVIN), dVIN has different features of histomorphology, risk of progression, and molecular pathogenesis. Read More

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http://dx.doi.org/10.5858/arpa.2018-0019-RSDOI Listing
December 2018
2 Reads

Use of antiepileptic mood stabilizers in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.005DOI Listing
March 2019
23 Reads

Dermoscopy of Inflammatory Genital Diseases: Practical Insights.

Dermatol Clin 2018 Oct;36(4):451-461

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Via L. Ariosto 35, Ferrara 44121, Italy.

Diagnosis of genital inflammatory disorders may be difficult for several reasons, such as their similar appearance, possible misdiagnosis with infectious and malignant conditions, and peculiar anatomic conditions that may lead to modification of clinical features. Dermoscopy could be included as a part of the clinical inspection of genital diseases to support diagnosis, as well as to ideally avoid unnecessary invasive investigation. Practical guidance for the use of dermoscopy in the assessment of the main inflammatory genital diseases is provided, namely for lichen sclerosus, lichen planus, psoriasis, lichen simplex chronicus, and plasma cell mucositis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183108
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http://dx.doi.org/10.1016/j.det.2018.05.013DOI Listing
October 2018
25 Reads

Less painful and effective intralesional injection method for lichen simplex chronicus.

J Am Acad Dermatol 2018 Dec 17;79(6):e105-e106. Epub 2018 Jul 17.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.07.009DOI Listing
December 2018
36 Reads

Itching at night: A review on reducing nocturnal pruritus in children.

Pediatr Dermatol 2018 Sep 26;35(5):560-565. Epub 2018 Jun 26.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

The most common causes of chronic nocturnal itching in children are atopic dermatitis and psoriasis, with lichen simplex chronicus and prurigo nodularis contributing to lesser degrees. Despite the prevalence of nocturnal itching, its pathophysiology remains poorly understood. The most troubling consequence of itching at night is poor quality of sleep. Read More

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http://dx.doi.org/10.1111/pde.13562DOI Listing
September 2018
19 Reads

Female Genital Itch.

Dermatol Clin 2018 Jul 26;36(3):225-243. Epub 2018 Apr 26.

Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:

Vulvar pruritus is a common complaint among young girls and women presenting to primary care physicians, gynecologists, and dermatologists. Female genital itch is especially disruptive because of its interference with sexual function and intimacy. Causes of vulvar itch are vast and may be inflammatory, environmental, neoplastic, or infectious, often with several causes coexisting simultaneously. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183001
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http://dx.doi.org/10.1016/j.det.2018.02.006DOI Listing
July 2018
22 Reads

Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

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https://www.tandfonline.com/doi/full/10.1080/00029157.2017.1
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http://dx.doi.org/10.1080/00029157.2017.1419457DOI Listing
July 2018
49 Reads

Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia.

Int J Gynecol Pathol 2019 Mar;38(2):175-182

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.C.W., C.P.C., M.R.N.) Stanford University Hospital, Palo Alto, California (E.Y.) Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium (M.H.) Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France (T.G., M.T.).

High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC). Read More

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http://dx.doi.org/10.1097/PGP.0000000000000509DOI Listing
March 2019
18 Reads

Linear terra firma-forme dermatosis of the midline back.

Cutis 2018 Mar;101(3):205-206

Department of Dermatology, McGovern Medical School, University of Texas, Houston, USA.

Terra firma-forme dermatosis (TFFD) is a benign and likely underdiagnosed disorder with relatively few reports in the literature. A 46-year-old woman presented to our clinic with a 3-year history of linear TFFD extending from the upper sacrum to the midline upper back. It initially was thought to be acanthosis nigricans or lichen simplex chronicus, and a topical steroid cream was applied without success. Read More

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March 2018
7 Reads

Lichen simplex chronicus on the scalp: exuberant clinical, dermoscopic, and histopathological findings.

An Bras Dermatol 2018 Jan-Feb;93(1):108-110

Thychology Outpatient Division at Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.

Lichen simplex chronicus is a skin disease that mostly affects female patients, with a peak incidence between ages 35 and 50 years. On the scalp, it appears as a single or multiple oval lesions, showing scaling and hair shaft loss or breakage. An important dermoscopic feature of the disease are the "broom fibers. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20186493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871373PMC
April 2018
11 Reads

Glucose Monitoring Dermopathy.

Authors:
Warren R Heymann

Skinmed 2018 1;16(1):74-75. Epub 2018 Feb 1.

Division of Dermatology, Department of Medicine and Department of Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;

A 75-year-old man had been monitoring his glucose using a blood glucose monitoring system at the same body site for at least 20 years (>7300 needlesticks). The asymptomatic skin lesion had been present for many years. He used the same site because it hurt less than the fingers and bled well. Read More

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February 2018
14 Reads

[New aspects in systemic treatment of atopic dermatitis].

Hautarzt 2018 Mar;69(3):217-224

Abteilung für Immundermatologie und experimentelle Allergologie, Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

In severe cases of atopic dermatitis (AD) systemic treatment is indicated. So far, cyclosporine and systemic glucocorticosteroids represented the only systemic treatment options approved for the indications of AD in Germany; however, from clinical practice there is increasing evidence for beneficial therapeutic effects in AD by other immunosuppressive or immunomodulatory substances, such as mycophenolate, methotrexate, alitretinoin and ustekinumab. Beyond this, ongoing research activities focus on a better understanding of genetic and immunological aspects of this chronic inflammatory skin disease. Read More

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http://dx.doi.org/10.1007/s00105-018-4131-8DOI Listing
March 2018
13 Reads

Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications.

Mod Pathol 2018 07 13;31(7):1131-1140. Epub 2018 Feb 13.

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.

The two main precursors of vulvar squamous cell carcinoma, usual and differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, pathogenesis, and natural history. Usual type VIN is often associated with high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor that shows increased expression in several types of human malignancies including breast and bladder carcinomas. Read More

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http://dx.doi.org/10.1038/s41379-018-0021-yDOI Listing
July 2018
7 Reads

Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva.

BJOG 2017 Aug;124 Suppl 3:87-92

College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Objective: To investigate the short- and long-term efficacy and influential factors of focused ultrasound for the treatment of non-neoplastic epithelial disorders of the vulva (NNEDV).

Design: A retrospective observational study.

Setting: A gynaecologic department in a single centre in China. Read More

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http://dx.doi.org/10.1111/1471-0528.14747DOI Listing
August 2017
18 Reads

Lichen Simplex Chronicus as an Essential Part of the Dermatologic Masquerade.

Open Access Maced J Med Sci 2017 Jul 24;5(4):556-557. Epub 2017 Jul 24.

Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.

A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. Read More

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http://dx.doi.org/10.3889/oamjms.2017.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535688PMC
July 2017
36 Reads

Skin diseases of the vulva: eczematous diseases and contact urticaria.

J Obstet Gynaecol 2018 Apr 7;38(3):295-300. Epub 2017 Aug 7.

a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.

Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i. Read More

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http://dx.doi.org/10.1080/01443615.2017.1329283DOI Listing
April 2018
10 Reads

Vulvar Pruritus and Lichen Simplex Chronicus.

Authors:
Rebecca Chibnall

Obstet Gynecol Clin North Am 2017 Sep;44(3):379-388

Department of Dermatology, Washington University School of Medicine, 5201 Midamerica Plaza, Suite 2300, St Louis, MO 63129, USA. Electronic address:

Vulvar pruritus and lichen simplex chronicus are common reasons for presentation to women's health practitioners, including gynecologists and dermatologists. Both conditions are multifactorial and are often confounded by other inflammatory, neoplastic, infectious, environmental, neuropathic, hormonal, and behavioral variables. Careful history taking and thorough physical examinations, including wet mount and potentially skin biopsy, are necessary for appropriate diagnosis. Read More

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http://dx.doi.org/10.1016/j.ogc.2017.04.003DOI Listing
September 2017
22 Reads

Atopic and Contact Dermatitis of the Vulva.

Obstet Gynecol Clin North Am 2017 Sep;44(3):371-378

Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:

Pruritus, or itch, is a common vulvar complaint that is often treated empirically as a yeast infection; however, yeast infections are just one of the many conditions that can cause vulvar itch. Ignoring other conditions can prolong pruritus unnecessarily. Atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis are extremely common noninfectious causes of vulvar itch that are often underdiagnosed by nondermatologists. Read More

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http://dx.doi.org/10.1016/j.ogc.2017.05.003DOI Listing
September 2017
16 Reads

Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis.

Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.

Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California.

Despite characteristic features, psoriasis can mimic other dermatologic conditions, such as seborrheic dermatitis, lichen simplex chronicus, and certain nutritional deficiencies such as pellagra. We present a patient with a longstanding history of severe plaque psoriasis who presented with disfiguring scaly plaques involving greater than 80% body surface area. The patient's disease was minimally responsive to multiple therapies. Read More

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May 2017
25 Reads

Dissociation and conversion symptoms in dermatology.

Clin Dermatol 2017 May - Jun;35(3):267-272. Epub 2017 Jan 21.

Department of Medicine, Faculty of Medicine, University of Toronto, Ontario, Canada.

Dissociation and conversion (defined as the somatic component of dissociation) can play an important mediating role in the exacerbation of the stress-reactive dermatoses (eg, psoriasis, idiopathic urticaria, atopic dermatitis), dermatoses that are exacerbated by excessive scratching (eg, lichen simplex chronicus, prurigo nodularis) and koebnerization, and the self-induced dermatoses (dermatitis artefacta, acne excoriée, skin picking disorder, trichotillomania, onychotillomania/onychophagia). Dissociative symptoms often coexist with obsessive-compulsive symptoms in the more severe cases of the self-induced dermatoses. Dissociation can play an important role in cutaneous sensory disorder (eg, scalp dysesthesia syndrome, stomatodynia/glossodynia, vulvodynia/scrotodynia, medically unexplained anesthesia). Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.01.003DOI Listing
November 2017
21 Reads

Lichenoid vulvar disease: A review.

Int J Womens Dermatol 2017 Mar 27;3(1):58-64. Epub 2017 Mar 27.

The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, NY.

Vulvar dermatoses are common, potentially debilitating conditions that can be seen by a variety of medical specialists. Lichenoid vulvar diseases, namely lichen sclerosus (LS), lichen planus (LP), and lichen simplex chronicus (LSC), can all negatively impact patients' quality of life and LS and LP also have an association with squamous cell carcinoma. It is essential that dermatologists are familiar with the unique features of each of these conditions to ensure the appropriate management and follow up. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475173002
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http://dx.doi.org/10.1016/j.ijwd.2017.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419035PMC
March 2017
54 Reads

[Neurodermatitis : Atopy of the skin].

Authors:
R Fölster-Holst

Ophthalmologe 2017 Jun;114(6):498-503

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Str. 7, 24105, Kiel, Deutschland.

Atopic dermatitis is one of the most common skin diseases and is associated with an impaired quality of life due to tormenting itching and stigmatization. The disease almost always manifests in early childhood and exhibits specific features in this phase, with involvement of the extensor sides of the extremities. During the further course of disease, the typical flexor involvement becomes quite clear and a considerable proportion of patients develop the associated atopic respiratory diseases. Read More

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http://dx.doi.org/10.1007/s00347-017-0495-xDOI Listing
June 2017
12 Reads

Protective Effect of Botulinum Toxin Type A Against Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.

Dermatol Surg 2017 Apr 24. Epub 2017 Apr 24.

*Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; †Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; ‡Institute of Dermatological Science, Seoul National University, Seoul, Korea; §Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Botulinum neurotoxin (BTX) A possesses various biological activities, including anti-inflammatory and antipruritic actions. Human and animal studies have shown that BTX is effective in treating histamine-induced itch, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar prevention. However, its effect on atopic dermatitis (AD) has not been studied yet. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001170DOI Listing
April 2017
14 Reads

Study of pruritus vulvae in geriatric age group in tertiary hospital.

Indian J Sex Transm Dis AIDS 2017 Jan-Jun;38(1):15-21

Department of Dermatology, Venereology, Leprosy, Government Medical College, Amritsar, Punjab, India.

Background: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. Read More

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http://dx.doi.org/10.4103/0253-7184.192632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389211PMC
April 2017
20 Reads

Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow.

J Cutan Pathol 2017 Jul 16;44(7):605-611. Epub 2017 May 16.

Sikl's Department of Pathology, Charles University in Prague, Medical Faculty in Pilsen, Pilsen, Czech Republic.

Background: The so-called acquired elastotic hemangioma (AEH) represents a peculiar vascular lesion affecting the sun-damaged skin of the extensor surface of the forearms or the lateral aspect of the neck of middle-aged or elderly women.

Methods: This is a clinicopathological and immunohistochemical study of a series of 6 lesions located on the knee or elbow showing epithelial features of lichen simplex chronicus (LSC)/prurigo nodularis (PN) with a marked subepidermal vascular proliferation closely resembling AEH.

Results: Microscopically, all cases of cutaneous lesions showed epithelial features of LSC/PN, that is compact hyperkeratosis with focal parakeratosis, irregular acanthosis, prominent hypergranulosis. Read More

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http://dx.doi.org/10.1111/cup.12945DOI Listing
July 2017
30 Reads

Perianal Dermatitis.

Dermatitis 2017 Jul/Aug;28(4):270-275

From the Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain.

Background: Perianal complaints are often consulted in dermatology clinics, and in many cases, a conclusive diagnosis is not easily made.

Objective: The aim of this study was to study and identify the epidemiological, clinical, and contact allergy features of patients with perianal dermatitis who attended at a contact dermatitis unit in a tertiary hospital in Spain.

Methods: Adult patients with long-lasting (>4 weeks) perianal dermatitis were recruited during the past 10 years for investigation and follow-up. Read More

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http://dx.doi.org/10.1097/DER.0000000000000274DOI Listing
May 2018
18 Reads

Vulvovaginal Issues in Mature Women.

Mayo Clin Proc 2017 03;92(3):449-454

Department of Dermatology, Mayo Clinic, Rochester, MN.

Mature women often present with symptomatic vulvovaginal atrophy and vulvar dermatoses, causing noncoital pain, dyspareunia, and sexual changes. Diagnosis of these conditions can be challenging, and long-term management is required to decrease morbidity and enhance quality of life. Vaginal estrogen therapies remain safe and effective for treating symptomatic vulvovaginal atrophy. Read More

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http://dx.doi.org/10.1016/j.mayocp.2016.10.031DOI Listing
March 2017
11 Reads

Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial.

J Allergy Clin Immunol 2017 Sep 24;140(3):845-853.e3. Epub 2017 Feb 24.

Institute of Medical Psychology, Justus-Liebig-University Giessen, Giessen, Germany.

Background: Atopic dermatitis (AD) is a chronic relapsing skin disease prevalent in 1% to 3% of adults in Western industrialized countries.

Objective: We sought to investigate the effectiveness of educational training in an outpatient setting on coping with the disease, quality of life, symptoms, and severity in adults with AD.

Methods: In this German prospective, randomized controlled multicenter study, adult patients with moderate-to-severe AD were educated by referring to a comprehensive 12-hour training manual consented by a multiprofessional study group from different centers (Arbeitsgemeinschaft Neurodermitisschulung für Erwachsene [ARNE]). Read More

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http://dx.doi.org/10.1016/j.jaci.2017.01.029DOI Listing
September 2017
29 Reads

2016 European guideline for the management of vulval conditions.

J Eur Acad Dermatol Venereol 2017 Jun 6;31(6):925-941. Epub 2017 Feb 6.

Department of Sexual Health, Churchill Hospital, Oxford, UK.

Vulval conditions may present to a variety of clinicians, such as dermatologists, gynaecologists and general practitioners. Women with these conditions are best managed by a multidisciplinary approach, which includes clear referral pathways between disciplines or access to a specialist multidisciplinary vulval service. Informed consent is a prerequisite for all examinations, investigations and treatments. Read More

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http://dx.doi.org/10.1111/jdv.14096DOI Listing
June 2017
19 Reads

Differences Between Men and Women in Chronic Scratching: A Psychodermatologic Study in Lichen Simplex Chronicus.

Actas Dermosifiliogr 2017 May 2;108(4):354-360. Epub 2017 Feb 2.

Faculty of Psychology, University of Murcia, Spain.

Introduction: Chronic scratching is common to many skin disorders. Being a female and presenting a high level of psychopathology are risk factors for chronic scratching. Yet, it is unclear why. Read More

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http://dx.doi.org/10.1016/j.ad.2016.12.002DOI Listing
May 2017
7 Reads

[Establishment of a SD rat model of vulvar lichen simplex chronicus and detection of the expression of protease activated receptor 2].

Nan Fang Yi Ke Da Xue Xue Bao 2017 Jan;37(1):30-35

State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Key Laboratory of Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine; Chongqing Medical University, Chongqing 40016, China.E-mail:

Objective: To establish a SD rat model of vulvar lichen simplex chronicus (LSC) and investigate the expression of protease activated receptor 2 (PAR2) in the genital skin.

Methods: Seventy female SD rats were randomly divided into group A (blank control group, n=10), group B (with application of acetone solution 3 times per week for 10 weeks, n=10), group C (with chronic mechanical irritation 3 times per week for 10 weeks, n=10), and group D (with topical treatment with 0.5= 7,12-Dimethylbenzanthracene [DMBA] in acetone solution and chronic mechanical irritation 3 times per week for 10 weeks, n=40). Read More

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January 2017
9 Reads

Psoriasiform dermatitides: A brief review.

Authors:
Mark R Wick

Semin Diagn Pathol 2017 May 14;34(3):220-225. Epub 2016 Dec 14.

Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Room 3020, University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:

Psoriasis vulgaris (PV)-the prototypical "psoriasiform" dermatitis-may assume a spectrum of histologic appearances, depending on whether it has been treated or not. Because of that relative lack of morphological uniformity, other skin disorders that feature epidermal acanthosis, with or without associated inflammation, may be confused diagnostically with PV. This brief review considers the clinicopathologic attributes of PV and its imitators, including chronic spongiotic dermatitides, lichen simplex chronicus, prurigo nodularis, pityriasis rubra pilaris, psoriasiform secondary syphilis, and Reiter syndrome. Read More

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http://dx.doi.org/10.1053/j.semdp.2016.12.006DOI Listing
May 2017
14 Reads

Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis.

Crit Rev Ther Drug Carrier Syst 2016 ;33(3):213-263

Department of Pharmacology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.

Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Read More

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http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.2016015219DOI Listing
February 2017
18 Reads
4.260 Impact Factor

Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA.

Mod Pathol 2017 03 11;30(3):448-458. Epub 2016 Nov 11.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Human papillomavirus-negative keratinizing vulvar cancers typically harbor TP53 mutations as do their precursors, differentiated vulvar intraepithelial neoplasia. However, atypical verruciform proliferations are also associated with these malignancies and their pathogenesis is poorly understood. This study compared 11 atypical verruciform lesions, including atypical verruciform hyperplasia, vulvar acanthosis with altered differentiation, and verruciform lichen simplex chronicus, with 14 human papillomavirus-negative keratinizing squamous cell carcinomas. Read More

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http://dx.doi.org/10.1038/modpathol.2016.187DOI Listing
March 2017
38 Reads

Obsessive-compulsive skin disorders: a novel classification based on degree of insight.

J Dermatolog Treat 2017 Jun 24;28(4):342-346. Epub 2016 Oct 24.

b Department of Dermatology, Psoriasis and Skin Treatment Center , University of California San Francisco , San Francisco , CA , USA.

Individuals with obsessive-compulsive features frequently visit dermatologists for complaints of the skin, hair or nails, and often progress towards a chronic relapsing course due to the challenge associated with accurate diagnosis and management of their psychiatric symptoms. The current DSM-5 formally recognizes body dysmorphic disorder, trichotillomania, neurotic excoriation and body focused repetitive behavior disorder as psychodermatological disorders belonging to the category of Obsessive-Compulsive and Related Disorders. However there is evidence that other relevant skin diseases such as delusions of parasitosis, dermatitis artefacta, contamination dermatitis, AIDS phobia, trichotemnomania and even lichen simplex chronicus possess prominent obsessive-compulsive characteristics that do not necessarily fit the full diagnostic criteria of the DSM-5. Read More

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http://dx.doi.org/10.1080/09546634.2016.1240864DOI Listing
June 2017
22 Reads

Tick Bite Alopecia: A Report and Review.

Am J Dermatopathol 2016 Nov;38(11):e150-e153

*Department of Pathology, Penn State College of Medicine, The Penn State Hershey Medical Center, Hershey, PA; †Penn State College of Medicine, The Penn State Hershey Medical Center, Hershey, PA; and ‡Department of Dermatology, Penn State College of Medicine, The Penn State Hershey Medical Center, Hershey, PA.

Tick bites can cause a number of local inflammatory reactions, which are often difficult to differentiate from those induced by other arthropod bites or stings. These include erythematous nodular or pustular lesions, erosive plaques, annular lesions of erythema chronicum migrans, and both scarring and nonscarring inflammatory alopecia. We report a case of nonscarring alopecia in a 21-year-old male who reported a recent history of tick bite to the scalp. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000598DOI Listing
November 2016
13 Reads

Clinical, epidemiological and therapeutic profile of patients with brachioradial pruritus in a reference service in dermatology.

An Bras Dermatol 2016 Jul-Aug;91(4):549-51

Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.

This is a cross-sectional study, conducted from May to November/2014, in a dermatology reference unit, through review of medical records and interviews. In a sample of 49 patients with brachioradial pruritus, we observed higher prevalence of Caucasian (81.6%) and women (73. Read More

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http://dx.doi.org/10.1590/abd1806-4841.201644767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999125PMC
May 2017
12 Reads

Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia.

Int J Gynecol Pathol 2017 May;36(3):273-280

Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky (M.B.P., M.A.S.)Department of Pathology, Floyd Memorial Hospital, New Albany, Indiana (M.M.)Department of Cellular Pathology, Barts and the London NHS Trust, London, United Kingdom (N.S.)Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, Canada (C.B.G.).

Differentiated vulvar intraepithelial neoplasia (dVIN), precursor of vulvar squamous cell carcinoma, is human papilloma virus independent and often found in a background of lichen sclerosus (LS) and lichen simplex chronicus (LSC). Subtle histologic findings make the diagnosis of dVIN difficult, and, although the use of p53 and Ki-67 has been of some value, there is a need for a better immunohistochemical marker. Cytokeratin 17 (CK17), a cytoskeletal intermediate filament protein, has previously been used in the diagnosis of anogenital lesions. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000317DOI Listing
May 2017
10 Reads

Onychotillomania: An underrecognized disorder.

J Am Acad Dermatol 2016 Dec 26;75(6):1245-1250. Epub 2016 Jul 26.

Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.

Onychotillomania is an uncommon and likely underreported condition in which patients repetitively manipulate the different constituents of the nail unit. Onychotillomania is characterized by a range of nonspecific findings, including bizarre morphology of the nail plate and damage to the nail bed and periungual skin. Histopathological changes are also nonspecific, but may be viewed as analogous to lichen simplex chronicus and prurigo nodularis of the skin. Read More

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http://dx.doi.org/10.1016/j.jaad.2016.05.036DOI Listing
December 2016
9 Reads

Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta-analysis, and recommendation for uniform use of 'atopic dermatitis'.

Allergy 2016 10 3;71(10):1480-5. Epub 2016 Aug 3.

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: The lack of standardized nomenclature for atopic dermatitis (AD) creates unnecessary confusion for patients, healthcare providers, and researchers. It also negatively impacts accurate communication of research in the scientific literature. We sought to determine the most commonly used terms for AD. Read More

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http://dx.doi.org/10.1111/all.12982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228598PMC
October 2016
11 Reads

Hypertrophic lichen planus versus prurigo nodularis: a dermoscopic perspective.

Dermatol Pract Concept 2016 Apr 30;6(2):9-15. Epub 2016 Apr 30.

Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

Background: Hypertrophic lichen planus (HLP) classically involves shin and ankles and is characterized by hyperkeratotic plaques and nodules. Prurigo nodularis (PN) is a chronic neurodermatitis that presents with intensely pruritic nodules. Histopathology of HLP and PN demonstrate epidermal hyperplasia, hypergranulosis, and compact hyperkeratosis. Read More

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http://dx.doi.org/10.5826/dpc.0602a03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866621PMC
April 2016
16 Reads

[Risk hidden in the small print? : Some food additives may trigger pseudoallergic reactions].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016 Jun;59(6):777-82

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Some food additives may trigger pseudoallergenic reactions. However, the prevalence of such an overreaction is - despite the increasing number of food additives - rather low in the general population. The most common triggers of pseudoallergic reactions to food are naturally occurring ingredients. Read More

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http://dx.doi.org/10.1007/s00103-016-2347-2DOI Listing
June 2016
14 Reads

Comparative Study of Quality of Life and Obsessive-Compulsive Tendencies in Patients With Chronic Hand Eczema and Lichen Simplex Chronicus.

Dermatitis 2016 May-Jun;27(3):127-30

From the *Department of Dermatology and Venereology, Andreas Sygros Skin Hospital; †2nd Department of Psychiatry, Attikon University Hospital; and ‡2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, Attikon General University Hospital, Athens, Greece.

Background: Lichen simplex chronicus (LSC) and chronic hand eczema (CHE) are 2 common dermatological disorders that affect physical, social, and psychological aspects of life. The aim of this study was to compare quality of life and obsessive-compulsive tendencies between patients with LSC and patients with CHE.

Materials And Methods: Sixty patients with LSC, 60 patients with CHE, and 60 healthy controls were included in the study. Read More

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http://dx.doi.org/10.1097/DER.0000000000000180DOI Listing
February 2018
45 Reads

[Definition and clinic of the allergic rhinitis].

Med Monatsschr Pharm 2016 Mar;39(3):97-9

The allergic rhinitis is the most common immune disorder with a lifetime prevalence of 24% and one of the most common chronic diseases at all--with tendency to rise. It occurs in childhood and influences the patients' social life, school performance and labour productivity. Furthermore the allergic rhinitis is accompanied by a lot of comorbidities, including conjunctivitis, asthma bronchiale, food allergy, neurodermatitis and sinusitis. Read More

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March 2016
8 Reads

To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease.

Am J Pathol 2016 05;186(5):1140-50

Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

Despite similar components, the heterogeneity of skin characteristics across the human body is enormous. It is classically believed that site-specific fibroblasts in the dermis control postnatal skin identity by modulating the behavior of the surface-overlying keratinocytes in the epidermis. To begin testing this hypothesis, we characterized the gene expression differences between volar (ventral; palmoplantar) and nonvolar (dorsal) human skin. Read More

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http://dx.doi.org/10.1016/j.ajpath.2015.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861769PMC
May 2016
30 Reads