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    Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.
    Am J Clin Hypn 2018 Jul;61(1):34-44
    a University of South Florida , Tampa , FL, USA.
    Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More
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    Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia.
    Int J Gynecol Pathol 2018 May 10. Epub 2018 May 10.
    Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.C.W., C.P.C., M.R.N.) Stanford University Hospital, Palo Alto, California (E.Y.) Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium (M.H.) Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France (T.G., M.T.).
    High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC). Read More
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    Linear terra firma-forme dermatosis of the midline back.
    Cutis 2018 Mar;101(3):205-206
    Department of Dermatology, McGovern Medical School, University of Texas, Houston, USA.
    Terra firma-forme dermatosis (TFFD) is a benign and likely underdiagnosed disorder with relatively few reports in the literature. A 46-year-old woman presented to our clinic with a 3-year history of linear TFFD extending from the upper sacrum to the midline upper back. It initially was thought to be acanthosis nigricans or lichen simplex chronicus, and a topical steroid cream was applied without success. Read More
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    Lichen simplex chronicus on the scalp: exuberant clinical, dermoscopic, and histopathological findings.
    An Bras Dermatol 2018 Jan-Feb;93(1):108-110
    Thychology Outpatient Division at Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.
    Lichen simplex chronicus is a skin disease that mostly affects female patients, with a peak incidence between ages 35 and 50 years. On the scalp, it appears as a single or multiple oval lesions, showing scaling and hair shaft loss or breakage. An important dermoscopic feature of the disease are the "broom fibers. Read More
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    Glucose Monitoring Dermopathy.
    Skinmed 2018 1;16(1):74-75. Epub 2018 Feb 1.
    Division of Dermatology, Department of Medicine and Department of Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;
    A 75-year-old man had been monitoring his glucose using a blood glucose monitoring system at the same body site for at least 20 years (>7300 needlesticks). The asymptomatic skin lesion had been present for many years. He used the same site because it hurt less than the fingers and bled well. Read More
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    [New aspects in systemic treatment of atopic dermatitis].
    Hautarzt 2018 Mar;69(3):217-224
    Abteilung für Immundermatologie und experimentelle Allergologie, Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
    In severe cases of atopic dermatitis (AD) systemic treatment is indicated. So far, cyclosporine and systemic glucocorticosteroids represented the only systemic treatment options approved for the indications of AD in Germany; however, from clinical practice there is increasing evidence for beneficial therapeutic effects in AD by other immunosuppressive or immunomodulatory substances, such as mycophenolate, methotrexate, alitretinoin and ustekinumab. Beyond this, ongoing research activities focus on a better understanding of genetic and immunological aspects of this chronic inflammatory skin disease. Read More
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    Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications.
    Mod Pathol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.
    The two main precursors of vulvar squamous cell carcinoma, usual and differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, pathogenesis, and natural history. Usual type VIN is often associated with high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor that shows increased expression in several types of human malignancies including breast and bladder carcinomas. Read More
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    Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva.
    BJOG 2017 Aug;124 Suppl 3:87-92
    College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
    Objective: To investigate the short- and long-term efficacy and influential factors of focused ultrasound for the treatment of non-neoplastic epithelial disorders of the vulva (NNEDV).

    Design: A retrospective observational study.

    Setting: A gynaecologic department in a single centre in China. Read More
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    Lichen Simplex Chronicus as an Essential Part of the Dermatologic Masquerade.
    Open Access Maced J Med Sci 2017 Jul 24;5(4):556-557. Epub 2017 Jul 24.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. Read More
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    Skin diseases of the vulva: eczematous diseases and contact urticaria.
    J Obstet Gynaecol 2018 Apr 7;38(3):295-300. Epub 2017 Aug 7.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i. Read More
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    Vulvar Pruritus and Lichen Simplex Chronicus.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):379-388
    Department of Dermatology, Washington University School of Medicine, 5201 Midamerica Plaza, Suite 2300, St Louis, MO 63129, USA. Electronic address:
    Vulvar pruritus and lichen simplex chronicus are common reasons for presentation to women's health practitioners, including gynecologists and dermatologists. Both conditions are multifactorial and are often confounded by other inflammatory, neoplastic, infectious, environmental, neuropathic, hormonal, and behavioral variables. Careful history taking and thorough physical examinations, including wet mount and potentially skin biopsy, are necessary for appropriate diagnosis. Read More
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    Atopic and Contact Dermatitis of the Vulva.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):371-378
    Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:
    Pruritus, or itch, is a common vulvar complaint that is often treated empirically as a yeast infection; however, yeast infections are just one of the many conditions that can cause vulvar itch. Ignoring other conditions can prolong pruritus unnecessarily. Atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis are extremely common noninfectious causes of vulvar itch that are often underdiagnosed by nondermatologists. Read More
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    Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California.
    Despite characteristic features, psoriasis can mimic other dermatologic conditions, such as seborrheic dermatitis, lichen simplex chronicus, and certain nutritional deficiencies such as pellagra. We present a patient with a longstanding history of severe plaque psoriasis who presented with disfiguring scaly plaques involving greater than 80% body surface area. The patient's disease was minimally responsive to multiple therapies. Read More
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    Dissociation and conversion symptoms in dermatology.
    Clin Dermatol 2017 May - Jun;35(3):267-272. Epub 2017 Jan 21.
    Department of Medicine, Faculty of Medicine, University of Toronto, Ontario, Canada.
    Dissociation and conversion (defined as the somatic component of dissociation) can play an important mediating role in the exacerbation of the stress-reactive dermatoses (eg, psoriasis, idiopathic urticaria, atopic dermatitis), dermatoses that are exacerbated by excessive scratching (eg, lichen simplex chronicus, prurigo nodularis) and koebnerization, and the self-induced dermatoses (dermatitis artefacta, acne excoriée, skin picking disorder, trichotillomania, onychotillomania/onychophagia). Dissociative symptoms often coexist with obsessive-compulsive symptoms in the more severe cases of the self-induced dermatoses. Dissociation can play an important role in cutaneous sensory disorder (eg, scalp dysesthesia syndrome, stomatodynia/glossodynia, vulvodynia/scrotodynia, medically unexplained anesthesia). Read More
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    Lichenoid vulvar disease: A review.
    Int J Womens Dermatol 2017 Mar 27;3(1):58-64. Epub 2017 Mar 27.
    The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, NY.
    Vulvar dermatoses are common, potentially debilitating conditions that can be seen by a variety of medical specialists. Lichenoid vulvar diseases, namely lichen sclerosus (LS), lichen planus (LP), and lichen simplex chronicus (LSC), can all negatively impact patients' quality of life and LS and LP also have an association with squamous cell carcinoma. It is essential that dermatologists are familiar with the unique features of each of these conditions to ensure the appropriate management and follow up. Read More
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    [Neurodermatitis : Atopy of the skin].
    Ophthalmologe 2017 Jun;114(6):498-503
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Str. 7, 24105, Kiel, Deutschland.
    Atopic dermatitis is one of the most common skin diseases and is associated with an impaired quality of life due to tormenting itching and stigmatization. The disease almost always manifests in early childhood and exhibits specific features in this phase, with involvement of the extensor sides of the extremities. During the further course of disease, the typical flexor involvement becomes quite clear and a considerable proportion of patients develop the associated atopic respiratory diseases. Read More
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    Protective Effect of Botulinum Toxin Type A Against Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.
    Dermatol Surg 2017 Apr 24. Epub 2017 Apr 24.
    *Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; †Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; ‡Institute of Dermatological Science, Seoul National University, Seoul, Korea; §Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Botulinum neurotoxin (BTX) A possesses various biological activities, including anti-inflammatory and antipruritic actions. Human and animal studies have shown that BTX is effective in treating histamine-induced itch, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar prevention. However, its effect on atopic dermatitis (AD) has not been studied yet. Read More
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    Study of pruritus vulvae in geriatric age group in tertiary hospital.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):15-21
    Department of Dermatology, Venereology, Leprosy, Government Medical College, Amritsar, Punjab, India.
    Background: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. Read More
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    Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow.
    J Cutan Pathol 2017 Apr 4. Epub 2017 Apr 4.
    Sikl's Department of Pathology, Charles University in Prague, Medical Faculty in Pilsen, Pilsen, Czech Republic.
    Background: The so-called acquired elastotic hemangioma (AEH) represents a peculiar vascular lesion affecting the sun-damaged skin of the extensor surface of the forearms or the lateral aspect of the neck of middle-aged or elderly women.

    Methods: This is a clinicopathological and immunohistochemical study of a series of 6 lesions located on the knee or elbow showing epithelial features of lichen simplex chronicus (LSC)/prurigo nodularis (PN) with a marked subepidermal vascular proliferation closely resembling AEH.

    Results: Microscopically, all cases of cutaneous lesions showed epithelial features of LSC/PN, that is compact hyperkeratosis with focal parakeratosis, irregular acanthosis, prominent hypergranulosis. Read More
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    Perianal Dermatitis.
    Dermatitis 2017 Jul/Aug;28(4):270-275
    From the Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain.
    Background: Perianal complaints are often consulted in dermatology clinics, and in many cases, a conclusive diagnosis is not easily made.

    Objective: The aim of this study was to study and identify the epidemiological, clinical, and contact allergy features of patients with perianal dermatitis who attended at a contact dermatitis unit in a tertiary hospital in Spain.

    Methods: Adult patients with long-lasting (>4 weeks) perianal dermatitis were recruited during the past 10 years for investigation and follow-up. Read More
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    Vulvovaginal Issues in Mature Women.
    Mayo Clin Proc 2017 03;92(3):449-454
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    Mature women often present with symptomatic vulvovaginal atrophy and vulvar dermatoses, causing noncoital pain, dyspareunia, and sexual changes. Diagnosis of these conditions can be challenging, and long-term management is required to decrease morbidity and enhance quality of life. Vaginal estrogen therapies remain safe and effective for treating symptomatic vulvovaginal atrophy. Read More
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    Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial.
    J Allergy Clin Immunol 2017 Sep 24;140(3):845-853.e3. Epub 2017 Feb 24.
    Institute of Medical Psychology, Justus-Liebig-University Giessen, Giessen, Germany.
    Background: Atopic dermatitis (AD) is a chronic relapsing skin disease prevalent in 1% to 3% of adults in Western industrialized countries.

    Objective: We sought to investigate the effectiveness of educational training in an outpatient setting on coping with the disease, quality of life, symptoms, and severity in adults with AD.

    Methods: In this German prospective, randomized controlled multicenter study, adult patients with moderate-to-severe AD were educated by referring to a comprehensive 12-hour training manual consented by a multiprofessional study group from different centers (Arbeitsgemeinschaft Neurodermitisschulung für Erwachsene [ARNE]). Read More
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    2016 European guideline for the management of vulval conditions.
    J Eur Acad Dermatol Venereol 2017 Jun 6;31(6):925-941. Epub 2017 Feb 6.
    Department of Sexual Health, Churchill Hospital, Oxford, UK.
    Vulval conditions may present to a variety of clinicians, such as dermatologists, gynaecologists and general practitioners. Women with these conditions are best managed by a multidisciplinary approach, which includes clear referral pathways between disciplines or access to a specialist multidisciplinary vulval service. Informed consent is a prerequisite for all examinations, investigations and treatments. Read More
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    Differences Between Men and Women in Chronic Scratching: A Psychodermatologic Study in Lichen Simplex Chronicus.
    Actas Dermosifiliogr 2017 May 2;108(4):354-360. Epub 2017 Feb 2.
    Faculty of Psychology, University of Murcia, Spain.
    Introduction: Chronic scratching is common to many skin disorders. Being a female and presenting a high level of psychopathology are risk factors for chronic scratching. Yet, it is unclear why. Read More
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    [Establishment of a SD rat model of vulvar lichen simplex chronicus and detection of the expression of protease activated receptor 2].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Jan;37(1):30-35
    State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Key Laboratory of Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine; Chongqing Medical University, Chongqing 40016, China.E-mail:
    Objective: To establish a SD rat model of vulvar lichen simplex chronicus (LSC) and investigate the expression of protease activated receptor 2 (PAR2) in the genital skin.

    Methods: Seventy female SD rats were randomly divided into group A (blank control group, n=10), group B (with application of acetone solution 3 times per week for 10 weeks, n=10), group C (with chronic mechanical irritation 3 times per week for 10 weeks, n=10), and group D (with topical treatment with 0.5= 7,12-Dimethylbenzanthracene [DMBA] in acetone solution and chronic mechanical irritation 3 times per week for 10 weeks, n=40). Read More
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    Psoriasiform dermatitides: A brief review.
    Semin Diagn Pathol 2017 May 14;34(3):220-225. Epub 2016 Dec 14.
    Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Room 3020, University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:
    Psoriasis vulgaris (PV)-the prototypical "psoriasiform" dermatitis-may assume a spectrum of histologic appearances, depending on whether it has been treated or not. Because of that relative lack of morphological uniformity, other skin disorders that feature epidermal acanthosis, with or without associated inflammation, may be confused diagnostically with PV. This brief review considers the clinicopathologic attributes of PV and its imitators, including chronic spongiotic dermatitides, lichen simplex chronicus, prurigo nodularis, pityriasis rubra pilaris, psoriasiform secondary syphilis, and Reiter syndrome. Read More
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    Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis.
    Crit Rev Ther Drug Carrier Syst 2016 ;33(3):213-263
    Department of Pharmacology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.
    Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Read More
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    Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA.
    Mod Pathol 2017 Mar 11;30(3):448-458. Epub 2016 Nov 11.
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
    Human papillomavirus-negative keratinizing vulvar cancers typically harbor TP53 mutations as do their precursors, differentiated vulvar intraepithelial neoplasia. However, atypical verruciform proliferations are also associated with these malignancies and their pathogenesis is poorly understood. This study compared 11 atypical verruciform lesions, including atypical verruciform hyperplasia, vulvar acanthosis with altered differentiation, and verruciform lichen simplex chronicus, with 14 human papillomavirus-negative keratinizing squamous cell carcinomas. Read More
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    Obsessive-compulsive skin disorders: a novel classification based on degree of insight.
    J Dermatolog Treat 2017 Jun 24;28(4):342-346. Epub 2016 Oct 24.
    b Department of Dermatology, Psoriasis and Skin Treatment Center , University of California San Francisco , San Francisco , CA , USA.
    Individuals with obsessive-compulsive features frequently visit dermatologists for complaints of the skin, hair or nails, and often progress towards a chronic relapsing course due to the challenge associated with accurate diagnosis and management of their psychiatric symptoms. The current DSM-5 formally recognizes body dysmorphic disorder, trichotillomania, neurotic excoriation and body focused repetitive behavior disorder as psychodermatological disorders belonging to the category of Obsessive-Compulsive and Related Disorders. However there is evidence that other relevant skin diseases such as delusions of parasitosis, dermatitis artefacta, contamination dermatitis, AIDS phobia, trichotemnomania and even lichen simplex chronicus possess prominent obsessive-compulsive characteristics that do not necessarily fit the full diagnostic criteria of the DSM-5. Read More
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    Tick Bite Alopecia: A Report and Review.
    Am J Dermatopathol 2016 Nov;38(11):e150-e153
    *Department of Pathology, Penn State College of Medicine, The Penn State Hershey Medical Center, Hershey, PA; †Penn State College of Medicine, The Penn State Hershey Medical Center, Hershey, PA; and ‡Department of Dermatology, Penn State College of Medicine, The Penn State Hershey Medical Center, Hershey, PA.
    Tick bites can cause a number of local inflammatory reactions, which are often difficult to differentiate from those induced by other arthropod bites or stings. These include erythematous nodular or pustular lesions, erosive plaques, annular lesions of erythema chronicum migrans, and both scarring and nonscarring inflammatory alopecia. We report a case of nonscarring alopecia in a 21-year-old male who reported a recent history of tick bite to the scalp. Read More
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    Clinical, epidemiological and therapeutic profile of patients with brachioradial pruritus in a reference service in dermatology.
    An Bras Dermatol 2016 Jul-Aug;91(4):549-51
    Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    This is a cross-sectional study, conducted from May to November/2014, in a dermatology reference unit, through review of medical records and interviews. In a sample of 49 patients with brachioradial pruritus, we observed higher prevalence of Caucasian (81.6%) and women (73. Read More
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    Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia.
    Int J Gynecol Pathol 2017 May;36(3):273-280
    Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky (M.B.P., M.A.S.)Department of Pathology, Floyd Memorial Hospital, New Albany, Indiana (M.M.)Department of Cellular Pathology, Barts and the London NHS Trust, London, United Kingdom (N.S.)Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, Canada (C.B.G.).
    Differentiated vulvar intraepithelial neoplasia (dVIN), precursor of vulvar squamous cell carcinoma, is human papilloma virus independent and often found in a background of lichen sclerosus (LS) and lichen simplex chronicus (LSC). Subtle histologic findings make the diagnosis of dVIN difficult, and, although the use of p53 and Ki-67 has been of some value, there is a need for a better immunohistochemical marker. Cytokeratin 17 (CK17), a cytoskeletal intermediate filament protein, has previously been used in the diagnosis of anogenital lesions. Read More
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    Onychotillomania: An underrecognized disorder.
    J Am Acad Dermatol 2016 Dec 26;75(6):1245-1250. Epub 2016 Jul 26.
    Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.
    Onychotillomania is an uncommon and likely underreported condition in which patients repetitively manipulate the different constituents of the nail unit. Onychotillomania is characterized by a range of nonspecific findings, including bizarre morphology of the nail plate and damage to the nail bed and periungual skin. Histopathological changes are also nonspecific, but may be viewed as analogous to lichen simplex chronicus and prurigo nodularis of the skin. Read More
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    Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta-analysis, and recommendation for uniform use of 'atopic dermatitis'.
    Allergy 2016 Oct 3;71(10):1480-5. Epub 2016 Aug 3.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    Background: The lack of standardized nomenclature for atopic dermatitis (AD) creates unnecessary confusion for patients, healthcare providers, and researchers. It also negatively impacts accurate communication of research in the scientific literature. We sought to determine the most commonly used terms for AD. Read More
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    Hypertrophic lichen planus versus prurigo nodularis: a dermoscopic perspective.
    Dermatol Pract Concept 2016 Apr 30;6(2):9-15. Epub 2016 Apr 30.
    Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.
    Background: Hypertrophic lichen planus (HLP) classically involves shin and ankles and is characterized by hyperkeratotic plaques and nodules. Prurigo nodularis (PN) is a chronic neurodermatitis that presents with intensely pruritic nodules. Histopathology of HLP and PN demonstrate epidermal hyperplasia, hypergranulosis, and compact hyperkeratosis. Read More
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    [Risk hidden in the small print? : Some food additives may trigger pseudoallergic reactions].
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016 Jun;59(6):777-82
    Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
    Some food additives may trigger pseudoallergenic reactions. However, the prevalence of such an overreaction is - despite the increasing number of food additives - rather low in the general population. The most common triggers of pseudoallergic reactions to food are naturally occurring ingredients. Read More
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    Comparative Study of Quality of Life and Obsessive-Compulsive Tendencies in Patients With Chronic Hand Eczema and Lichen Simplex Chronicus.
    Dermatitis 2016 May-Jun;27(3):127-30
    From the *Department of Dermatology and Venereology, Andreas Sygros Skin Hospital; †2nd Department of Psychiatry, Attikon University Hospital; and ‡2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, Attikon General University Hospital, Athens, Greece.
    Background: Lichen simplex chronicus (LSC) and chronic hand eczema (CHE) are 2 common dermatological disorders that affect physical, social, and psychological aspects of life. The aim of this study was to compare quality of life and obsessive-compulsive tendencies between patients with LSC and patients with CHE.

    Materials And Methods: Sixty patients with LSC, 60 patients with CHE, and 60 healthy controls were included in the study. Read More
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    [Definition and clinic of the allergic rhinitis].
    Med Monatsschr Pharm 2016 Mar;39(3):97-9
    The allergic rhinitis is the most common immune disorder with a lifetime prevalence of 24% and one of the most common chronic diseases at all--with tendency to rise. It occurs in childhood and influences the patients' social life, school performance and labour productivity. Furthermore the allergic rhinitis is accompanied by a lot of comorbidities, including conjunctivitis, asthma bronchiale, food allergy, neurodermatitis and sinusitis. Read More
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    To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease.
    Am J Pathol 2016 05;186(5):1140-50
    Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:
    Despite similar components, the heterogeneity of skin characteristics across the human body is enormous. It is classically believed that site-specific fibroblasts in the dermis control postnatal skin identity by modulating the behavior of the surface-overlying keratinocytes in the epidermis. To begin testing this hypothesis, we characterized the gene expression differences between volar (ventral; palmoplantar) and nonvolar (dorsal) human skin. Read More
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    Inhibition of IKK-β by epidioxysterols from the flowers of Calotropis gigantea (Niu jiao gua).
    Chin Med 2016 2;11. Epub 2016 Mar 2.
    State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China.
    Background: Calotropis gigantea (Asclepiadaceae) (Niu jiao gua) has been used as a poultice in Chinese medicine for treating inflammatory skin diseases, e.g., neurodermatitis. Read More
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    Level of use and safety of botanical products for itching vulvar dermatoses. Are patch tests useful?
    Contact Dermatitis 2016 May 29;74(5):289-94. Epub 2016 Feb 29.
    Dipartimento di Scienze Mediche - Sezione di Dermatologia e Malattie Infettive, University of Ferrara, 44100, Ferrara, Italy.
    Background: Topical remedies based on botanical ingredients are popular.

    Objectives: To assess: (i) the usage of botanical substances in subjects affected with itching and chronic vulvar complaints; (ii) the incidence of side-effects associated with their use and the frequency of contact allergy; (iii) the diagnostic usefulness of patch testing.

    Methods: Sixty-six patients were provided with a questionnaire to assess the prevalence and type of topical botanical preparations used and the occurrence of adverse reactions. Read More
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    Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients.
    Health Qual Life Outcomes 2016 Feb 3;14:17. Epub 2016 Feb 3.
    Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 157 Xiwu Road, Xincheng District, Xi'an, Shaanxi Province, 710004, People's Republic of China.
    Background: The Dermatology Life Quality Index (DLQI) is the most widely used measure of health-related quality of life (HRQoL) associated with skin disease. Recently, the psychometric properties of the DLQI have caused some controversy because the instrument appears not to meet the requirements of modern test theory. The purpose of this study was to assess whether these psychometric issues also occur in Chinese patients with neurodermatitis. Read More
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    Leprosy in the Bible.
    Clin Dermatol 2016 Jan-Feb;34(1):3-7. Epub 2015 Nov 17.
    Domestic and Specialized Medicine Centre "Dilmed", ul. Bohaterów Monte Cassino 3, 40-231 Katowice, Poland. Electronic address:
    For many years, the biblical term tzaraat has referred to leprosy. In fact, the disease or diseases described under this name have no relationship to leprosy, as it was known in the Middle Ages or today; moreover, the term referred not only to skin disease, but also to the state of the ritual impurity and punishment for the sins. Although the real nature of tzaraat remains unknown, the differential diagnosis might include the following: Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, scarlet fever, lupus erythematosus, lichen sclerosus et atrophicus, folliculitis decalvans, morphea, sarcoidosis, and lichen planopilaris. Read More
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    Skin disease in United Nations peacekeepers in Lebanon.
    J R Army Med Corps 2017 Feb 8;163(1):27-30. Epub 2016 Jan 8.
    Department of Dermatology, Chengdu Military General Hospital, Chengdu, China.
    Objectives: Skin disease is one of the major components of health problems for soldiers either during war or peacetime. Despite increased numbers and scale of military missions, dermatological survey is limited. The aim of this study was to outline the dermatological profile in international peacekeepers in Lebanon and to explore the features of disease pattern. Read More
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    The serine protease inhibitor of Kazal-type 9 (SPINK9) is expressed in lichen simplex chronicus, actinic keratosis and squamous cell carcinoma.
    Arch Dermatol Res 2016 Mar 8;308(2):133-7. Epub 2016 Jan 8.
    Department of Dermatology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany.
    The serine protease inhibitor of Kazal-type (SPINK) 9 was reported to be exclusively expressed in palmoplantar skin. SPINK9 is a specific inhibitor of the serine protease kallikrein-related peptidase 5 (KLK5), which contributes to the desquamation process of the stratum corneum. Herein, we demonstrated that SPINK9 is also expressed in lichen simplex chronicus. Read More
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    Lesions With an Epidermal Hyperplastic Pattern: Morphologic Clues in the Differential Diagnosis.
    Am J Dermatopathol 2016 Jan;38(1):1-16; quiz 17-9
    Consultant Hisopathologist, Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.
    In this report, we review the most common entities that show a epidermal hyperplastic pattern in the biopsy. These entities include inflammatory, reactive, infectious, hamartomatous, and tumoral conditions, each with a very different prognosis. Therefore, an approach based on the classic "patterns and clues" tools used in dermatopathology can bring a lot of information to the dermatopathologist or the general pathologist evaluating these lesions. Read More
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