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Dermatol Pract Concept 2022 May 1;12(2):e2022069. Epub 2022 Apr 1.

Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Abstract: Eccrine squamous syringometaplasia (ESS) has been associated with several conditions including morphea, linear scleroderma, and burns. It is yet to be reported in lichen sclerosus et atrophicus (LSA). We describe a bullous LSA plaque on the forearm of a woman with pre-existing genital LSA and vitiligo. Read More

Front Immunol 2022 3;13:887279. Epub 2022 May 3.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Bullous pemphigoid (BP) represents the most common autoimmune bullous disease and is characterized by IgG autoantibodies targeting collagen XVII (BP180). BP has reportedly been occurred in association with other inflammatory skin diseases. Here, we describe the unusual occurrence of BP in a female patient with a concomitant history of generalized morphea (localized scleroderma, LoS) and cutaneous and genital lichen sclerosus (LiS). Read More

Bull Exp Biol Med 2022 Apr 2;172(6):734-737. Epub 2022 May 2.

Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia.

Lichen sclerosus of the vulva is a common, but poorly studied disease. We assessed the level of transcriptional activity of APAF1, BAX, BCL2, BIRC5, CCND1, DAPK1, MCL1, and MYC genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). Analysis of transcriptional activity was performed by real-time PCR using specific primers and SYBR Green intercalating dye. Read More

Acta Obstet Gynecol Scand 2022 Jun 28;101(6):657-692. Epub 2022 Apr 28.

Department of Obstetrics and Gynecology, Nordsjaellands Hospital, Institute of Clinical Medicine, University of Copenhagen, Hillerød, Denmark.

In recent years, LASER has been introduced as a minimally invasive treatment for a broad range of vaginal and vulvar symptoms and diseases. However, the efficacy and safety of vaginal and vulvar LASER has continuously been questioned. The aim of this study is to create an overview of the current literature and discuss the controversies within the use of LASER for genitourinary syndrome of menopause, vulvovaginal atrophy, urinary incontinence and lichen sclerosus. Read More

J Healthc Eng 2022 31;2022:3495099. Epub 2022 Mar 31.

Department of Ediatric Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou City 075000, Hebei Province, China.

Objective: The objective is to explore the treatment effect of mometasone furoate cream on lichen sclerosus et atrophicus (LSeA) of external genitalia in boys and its correlation with Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88).

Methods: A total of 100 boys treated in our hospital from January 2021 to January 2023 due to clinical manifestations in the external genitalia were selected as the study objects. All boys received redundant circumcision treatment, their protein expression of TLR4 and MyD88 in foreskin tissues was measured by BCA protein assay and western blot, and mometasone furoate cream was applied to those who were pathologically diagnosed with LSeA, so as to compare the levels of serum inflammatory factors and urodynamic indicators in the child patients before and after treatment. Read More

Eur J Obstet Gynecol Reprod Biol 2022 May 10;272:88-95. Epub 2022 Mar 10.

University of Toronto, Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Canada; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.

Background: Lichen sclerosus (LS) is a chronic inflammatory skin disease that mostly affects the anogenital region of women and lowers patients' quality of life. Current standard treatment of LS is topical steroids.

Objective: To evaluate the efficacy of topical progesterone 8% ointment and compare to standard therapy with topical clobetasol propionate 0. Read More

Adv Exp Med Biol 2022 ;1367:155-172

Mismedicine Organization and Research Institute, Beverly Hills, CA, USA.

Morphea and lichen sclerosis et atrophicus (LSA) are two distinct immune-mediated diseases with a dominant presentation of dermal fibrosis and sclerosis. The two diseases have many similar clinical and histological features and tend to co-occur. Both diseases are thought to result from a derailment of the normal response to environmental triggers. Read More

Exp Dermatol 2022 05 16;31(5):689-699. Epub 2022 Mar 16.

Department of Plastic-, Reconstructive- and Hand Surgery, Utrecht University Medical Center, Utrecht University, Utrecht, The Netherlands.

Lichen sclerosus (LS) is a chronic inflammatory dermatosis that mostly affects the genital and anal skin areas. Symptoms may vary from pruritis and pain to sexual dysfunction; however, LS can also be asymptomatic. LS occurs at all ages and in both sexes. Read More

Australas J Dermatol 2022 May 9;63(2):248-250. Epub 2022 Mar 9.

Department of Dermatology, St Vincent's Hospital, Melbourne, Australia.

Vulval Lichen Sclerosus (VLS) is a chronic inflammatory dermatosis that significantly impacts the quality of life. We report 2 cases of severe treatment-resistant VLS treated with subcutaneous adalimumab. One patient showed modest clinical improvement with no significant improvement in quality-of-life measures. Read More

Pediatr Med Chir 2022 Mar 1;44(1). Epub 2022 Mar 1.

Pediatric Surgery, Department of Women and Children; Pediatric Surgery, Department of Medical, Surgical and Neurological Sciences, S. Maria alle Scotte Hospital, University of Siena, Siena.

Lichen Sclerosus (LS) is a chronic inflammatory skin disease with unknown etiology. In pediatric age the main disease "lichenlinked" is the phimosis in male. This is a retrospective study that reports the experience of our clinic and review of the literature. Read More

Int J STD AIDS 2022 Apr 28;33(5):522-524. Epub 2022 Feb 28.

Department of Dermatology, 8964University College London Hospitals NHS Foundation Trust, London, UK.

Male genital lichen sclerosus (MGLSc) is a chronic inflammatory dermatosis that predominantly affects uncircumcised males. Several aetiological factors have been described, with growing evidence supporting chronic urine exposure of susceptible epithelium being crucial to its pathogenesis. We describe a 45-year-old man with a 2-year history of MGLSc at the site of a urethrocutaneous fistula secondary to a penile piercing. Read More

J Obstet Gynaecol Can 2022 Feb;44(2):121-122.e1

Président, Réseau canadien de prévention du VPH; coprésident, VPH Action Globale; et président, International Union against STI-Canada.

J Obstet Gynaecol Can 2022 Feb;44(2):119-120.e1

Chair of the Canadian Network for HPV Prevention, co-president of HPV Global Action, and president of the International Union against STI-Canada.

Folia Med Cracov 2021 Dec;61(4):93-100

First Department of Pediatric Surgery, Aristotle University of Thessaloniki Greece, General Hospital "G.Gennimatas", Thessaloniki, Greece.

Balanitis Xerotica Obliterans is a chronic, progressive, sclerosing inflammation of unclear etiology. It involves the external genitalia of males and more specifically the prepuce and its frenulum, the glans, and the external urethral meatus while it may extend to the peripheral part of the urethra. Recent studies have noted an increasing incidence in the paediatric population. Read More

Clin Exp Dermatol 2022 Jun 18;47(6):1124-1130. Epub 2022 Apr 18.

Department of Dermatology, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.

Background: Male genital lichen sclerosus (MGLSc) can lead to significant sexual dysfunction and urological morbidity, and is also a risk factor for premalignant disease (penile intraepithelial neoplasia and penile cancer), particularly squamous cell carcinoma. Although the precise aetiopathogenesis of MGLSc remains controversial, accumulated evidence indicates that it is related to chronic, intermittent, occluded exposure to urine.

Aim: To perform spatial mapping of MGLSc across the human prepuce and assess how this supports the urinary occlusion hypothesis. Read More

Int Urol Nephrol 2022 Apr 1;54(4):763-772. Epub 2022 Feb 1.

Department of Urology, Medical University of Gdańsk, Mariana Smoluchowskiego 17 street, 80-214, Gdańsk, Poland.

Purpose: To assess the expression of selected cytokines in penile lichen sclerosus (PLS) and associate them with the occurrence of micro-incontinence (MI) in different stages of PLS.

Methods: The skin biopsies from 49 PLS affected, and 13 from nonlesional foreskins (healthy control adult males undergoing circumcision due to phimosis caused by short frenulum) were obtained. All specimens were used for RNA extraction and RT-qPCR. Read More

Dermatol Ther 2022 04 13;35(4):e15338. Epub 2022 Feb 13.

Department of Plastic and Regenerative Surgery, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.

Lichen Sclerosus is a chronic-relapsing inflammatory skin disease usually involving the anogenital region lacking a resolutive therapy. Potent to high-potent topical corticosteroids are considered to be the standard first-line treatment. The objective of this preliminary study is to evaluate the efficacy of injecting Hybrid Cooperative Complexes of Hyaluronic Acid (HCC) in the treatment of Vulvar Lichen Sclerosus (VLS). Read More

Dermatol Pract Concept 2021 Oct 1;11(4):e2021072. Epub 2021 Oct 1.

Dermatology, IRCCS Policlinico di Sant'Orsola, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum Università di Bologna, Italy.

BMJ Case Rep 2022 Jan 6;15(1). Epub 2022 Jan 6.

University College London Hospitals NHS Foundation Trust, London, London, UK.

Lichen sclerosus (LSc) is a chronic inflammatory condition commonly affecting the anogenital area, with extragenital involvement seen in less than 1%-20% of cases. Concomitant extragenital and genital LSc is extremely rare in male patients. The Koebner phenomenon is a recognised feature of LSc; here we present a rare case of extragenital LSc occurring in tattooed skin. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Dec;43(6):849-855

Graduate School,CAMS and PUMC,Beijing 100730,China.

Objective To investigate the clinicopathological characteristics of established genital and extragenital lichen sclerosus(LS)and compare the differences between them. Method The clinicopathological data of 55 patients with established genital and extragenital LS diagnosed by pathological examination in the Department of Dermatology of Beijing Hospital were retrospectively analyzed. Results The 55 patients included 11 males and 44 females. Read More

J Low Genit Tract Dis 2022 Jan;26(1):46-52

Division of Pediatric and Adolescent Gynecology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT.

Objective/purpose: Delay in diagnosis of childhood lichen sclerosus (LS) can be ameliorated with an efficient evaluation tool. We sought to create a useful prognostic tool for rapid and accurate risk stratification for LS in premenarchal girls.

Method: We conducted a retrospective chart review at a single institution of premenarchal girls presenting with vulvovaginal complaints at a specialty pediatric and adolescent gynecology clinic at a major academic center. Read More

PLoS One 2021 15;16(12):e0261505. Epub 2021 Dec 15.

Department of Urology, Lahey Hospital & Medical Center, Burlington, Massachusetts, United States of America.

Purpose: To better understand the pathophysiology of lichen sclerosus (LS) urethral stricture disease (USD), we aimed to investigate expression profiles of microRNAs (miRNAs) in tissue samples from men undergoing urethroplasty.

Methods: Urethral stricture tissue was collected from 2005-2020. Histologic features diagnostic of LS were the basis of pathologic evaluation. Read More

Ann Pathol 2022 Jan 10;42(1):49-57. Epub 2021 Dec 10.

Service de pathologie, hôpital Cochin, Paris 14e, cabinet de dermatopathologie Mathurin-Moreau, Paris 19(e), France. Electronic address:

Lichen sclerosus, lichen planus, psoriasis and plasma cell vulvitis are the most common diagnosis amongst inflammatory vulval diseases, the most frequently suspected by the clinicians and the most frequently diagnosed by the pathologist. We expose their clinical and pathological aspects and detail the most recurrent diagnosis difficulties. Read More

Ann Pathol 2022 Jan 2;42(1):15-19. Epub 2021 Dec 2.

Centre National de Dermatopathologie - La Roquette, 56 rue de la Roquette, 75011 Paris, France.

Penile carcinogenesis can be superposed on vulvar carcinogenesis, with two pathways : with or without a link to HPV. Penile squamous cell carcinomas arise from precursor lesions: penile intraepithelial neoplasia (PeIN) defined by the presence of intraepithelial atypia, which can progress to invasive squamous cell carcinoma. Differentiated PeINs not linked to HPV, affect elderly men with inflammatory lesions, most often lichen sclerosus. Read More

Int J Dermatol 2022 07 3;61(7):e259-e261. Epub 2021 Dec 3.

Dermatological Department, Wuhan No.1 Hospital, Wuhan, Hubei, PR China.

J Geriatr Oncol 2022 04 22;13(3):282-286. Epub 2021 Nov 22.

Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address:

Vulvar dermatoses are often debilitating chronic skin conditions associated with pain and pruritus. In oncologic patients, cancer treatments can precipitate and exacerbate vulvar dermatoses. Cytotoxic chemotherapy, hormonal therapies, and local pelvic radiation therapy can lead to vulvar symptoms, and cancer treatment-induced vulvar conditions include graft-versus-host-disease and radiation dermatitis. Read More

Am J Dermatopathol 2021 Dec;43(12):935-938

Departments of Dermatology and Venereology, and.

Background: "Line sign," "cookie cutter sign," "square biopsy sign," "high eccrine glands sign" have been previously described in morphoea and lichen sclerosus. We found focal areas of thickened collagen bundles with lymphocytes interspersed between them in several biopsies of these conditions.

Materials And Methods: We reviewed slides of sclerosing disorders obtained from the archives of the pathology department in our hospital for the period 2013-2019. Read More

Pediatr Dermatol 2022 Jan 4;39(1):22-30. Epub 2021 Nov 4.

Department of Dermatology, Royal North Shore Hospital, Sydney, NSW, Australia.

Background: Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis of the genital skin, with up to 20% of cases in the pediatric age group. Limited data exist concerning the prognosis of pediatric VLS, particularly the likelihood of permanent architectural change and whether this can be prevented by compliance with topical corticosteroid treatment (TCS).

Objective: To evaluate the extent to which compliance to TCS treatment influences the risk of developing vulvar structural abnormalities, including clitoral phimosis and diminutive or fused labia minora. Read More

Cancer Immunol Immunother 2022 Jun 27;71(6):1545-1548. Epub 2021 Oct 27.

Skin Cancer Unit, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

Lichenoid reactions are one of the most frequently observed toxicities with anticancer agents and, recently, a rapid emergence of immunotherapies in oncology has hastened the need to better characterize their unique toxicity profiles, particularly for less common skin toxicities, including anogenital lichen sclerosus et atrophicus (LSA). This case series describes four patients with advanced cancer (one melanoma, two lung cancers, and one kidney tumor) developing LSA lesions while receiving an immunotherapy. Medical records from 2017 to 2020 were retrospectively reviewed. Read More