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Urology 2020 Jun 23. Epub 2020 Jun 23.

Department of Urology, University of North Carolina-Chapel Hill.

Objective: To demonstrate a technique for performing panniculectomy and skin graft for a patient with adult buried penis, highlighting a number of technical modifications that allow for the procedure to be performed as an outpatient.

Methods: Pannus is mobilized with a modified trapezoid incision, leaving superior attachments intact for skin graft harvest. Diseased penile skin is removed, defect is measured, and an appropriately sized split thickness skin graft is harvested from the pannus in 2 inch sections at a depth of 18/1,000. Read More

Paediatr Child Health 2020 Jun 20;25(4):241-245. Epub 2019 Mar 20.

Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alberta.

Within the paediatric population, changing patterns of circumcisions have confounded the epidemiology and presentation of lichen sclerosus (LS). We sought to evaluate the incidence, demographics, and clinical features of patients presenting to a single Albertan paediatric urologist with LS. This retrospective descriptive analysis evaluated all paediatric patients referred for phimosis to a single paediatric urologist in Edmonton, Alberta. Read More

J Cutan Pathol 2020 Jun 13. Epub 2020 Jun 13.

Department of Dermatology, Inha University, School of Medicine, Incheon, Republic of Korea.

Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatosis of the anogenital area, and approximately 15-20% of patients with LSA have extragenital lesions. Here, we report the case of an 18-year-old Korean man presenting with multiple asymptomatic punctated hypopigmented atrophic macules on the dorsum of both feet. Dermoscopic examination revealed hypopigmented atrophic macules with several central keratotic plugs. Read More

Obstet Gynecol Int 2020 21;2020:7480754. Epub 2020 Apr 21.

Department of Gynecologic Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, Alberta, Canada.

. Vulvar lichen sclerosus (VLS) is a chronic inflammatory disorder, which affects women of all ages. With numerous controversies as regards to the nomenclature, diagnosis and its association with neoplastic conditions, we decided to conduct a scoping review on this subject. Read More

Gac Med Mex 2019 ;155(5):483-491

Instituto Nacional de Pediatría, Dermatology Department, Mexico City, Mexico.

Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. Classification of the disease is not simple due to its multiple presentations; however, it is useful in order to define the treatment, which should be individualized and started early to avoid cosmetic and functional complications. Read More

BJOG 2020 06 9;127(7):814-819. Epub 2020 Mar 9.

Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.

Objective: To assess the incidence of lichen sclerosus (LS) in women and the all-cause and cause-specific mortality of women with LS.

Design: Population-based descriptive study.

Setting: Finland. Read More

Urologe A 2020 Mar;59(3):271-277

Medbase/santemed Gesundheitszentren AG, Frauenfeld, Schweiz.

Lichen sclerosus (LS) is a chronic inflammatory disease of the skin. It mainly affects the anogenital area. More knowledge of the disease is needed to avoid delay in diagnosis as early treatment may cure the disease in some and reduce or prevent scarring. Read More

Dermatol Online J 2019 Dec 15;25(12). Epub 2019 Dec 15.

Department of Dermatology, University of Texas Medical Branch, Galveston, TX.

Lichen sclerosus (LS) is a chronic dermatologic condition characterized by atrophic porcelain-appearing plaques that can cause intense discomfort and eventually lead to destruction of local architecture. Lichen sclerosus most commonly arises in the anogenital area, but up to 20% of cases can present on extragenital skin. Rarely, LS can also present with hemorrhage and bullae; the mechanism by which this occurs is unknown. Read More

Dermatol Ther 2020 Mar 10;33(2):e13239. Epub 2020 Feb 10.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

Urology 2020 Mar 7;137:e1-e2. Epub 2020 Jan 7.

Gynecology, Yale University School of Medicine, New Haven, CT.

Lichen sclerosus (LS) is a chronic inflammatory dermatosis commonly visualized in the anogenital region with porcelain-white atrophic patches that extend to the perianal region in a figure-of-eight configuration. While LS is known to increase lower urinary tract symptoms and incontinence in postmenopausal women, the age distribution is bimodal and literature on the LS impact in prepubertal girls remains limited. There is an association with autoimmune conditions and the pathogenesis is thought to be autoimmune with an underlying genetic predisposition. Read More

J Urol 2020 04 7;203(4):777-778. Epub 2020 Jan 7.

University of Washington School of Medicine, Seattle, Washington.

Eur J Dermatol 2019 12;29(6):661-662

Department of Dermatology, Chonbuk National University Medical School,, Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

Clin Dermatol 2019 Sep - Oct;37(5):561-579. Epub 2019 Jul 17.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

White diseases are a heterogenous group characterized by hypopigmentation or depigmentation. Skin and eye color are determined by the number and size of melanosomes present. Melanin is produced by melanosomes in the melanocytes present within the epidermis of the skin, uvea, and retinal pigmented epithelium (RPE). Read More

World J Urol 2019 Dec 5. Epub 2019 Dec 5.

Department of Urology Monterrey, Hospital San Jose TecSalud, Nuevo Leon, Mexico.

Introduction: Lichen sclerosus (LS) is a common cause of urethral stricture disease. The purpose of this article is to review the literature over the past 5 years, to describe current treatment of lichen sclerosus as it relates to urethral stricture in men.

Materials And Methods: Literature reviews were performed using PUBMED, with search terms "lichen scleros*" and "urethral stenosis", as well as "lichen scleros*" and "urethral stricture". Read More

World J Urol 2019 Nov 30. Epub 2019 Nov 30.

Department of Urology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Objectives: To describe the operative technique and report outcomes from the largest series of patients who underwent single-stage dorsal inlay buccal mucosal graft urethroplasty (BMGU) for isolated meatal stenoses and fossa navicularis strictures.

Patients And Methods: First, we evaluated patients who underwent single-stage BMGU for distal urethral strictures (meatus and fossa navicularis) between 2009 and 2016 at our department. Clinical and surgical characteristics were prospectively collected in an institutional database. Read More

Gac Med Mex 2019 ;155(5):522-531

Instituto Nacional de Pediatría, Servicio de Dermatología, Ciudad de México, México.

Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. Classification of the disease is not simple due to its multiple presentations; however, it is useful in order to define the treatment, which should be individualized and started early to avoid cosmetic and functional complications. Read More

Pediatr Dermatol 2020 Jan 4;37(1):64-68. Epub 2019 Nov 4.

Departments of Pediatrics and Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background/objectives: It remains uncertain as to whether genital vitiligo of childhood is segmental or a forme fruste of non-segmental disease. This type of vitiligo is sometimes termed figure-of-eight disease due to female predominance and perineal and perianal hypopigmentation or depigmentation around two orifices, the anal and vaginal introitus. The objective of this series was to categorize the features of genital-limited vitiligo of childhood including comorbidities, family history, and long-term course. Read More

Urology 2020 Jan 23;135:124-132. Epub 2019 Oct 23.

University of Washington School of Medicine, Department of Urology, Seattle, WA.

Context: Phimosis is considered virtually universal in newborn males and likely to resolve within a few years. Persistent phimosis can result in pain, sexual dysfunctions, increased risk of penile inflammatory conditions and penile cancer. There are two forms - primary phimosis and secondary phimosis - the latter often representing a consequence of lichen sclerosis, diabetes and obesity. Read More

Ann Dermatol Venereol 2019 Dec 15;146(12):812-816. Epub 2019 Oct 15.

Service de dermatologie, centre des MST, hôpital Saint-Louis, 42, rue Bichat, 75010 Paris, France.

Introduction: Malakoplakia is a granulomatosis of infectious origin in reaction to a chronic bacterial infection (most commonly urinary Escherichiacoli) related to an acquired phagocytosis impairment.

Patients And Methods: We report a case of penile malakoplakia in a 69-year-old man with lichen sclerosis and stenosis of the urinary meatus leading to recurrent urinary tract infections. The clinical aspect was suggestive of squamous cell carcinoma of the glans developing on lichen sclerosus, but histological examination revealed penile malakoplakia. Read More

J Urol 2020 04 17;203(4):773-778. Epub 2019 Oct 17.

Lahey Hospital and Medical Center, Burlington, Massachusetts.

Purpose: Urethroplasty of lichen sclerosus strictures has a significantly higher failure rate than strictures due to other causes. We sought to determine predictors of urethroplasty failure in men with lichen sclerosus urethral stricture disease by evaluating protein expression profiles.

Materials And Methods: Urethral tissue was excised from patients with lichen sclerosus who were undergoing urethroplasty of urethral stricture disease at a single institution. Read More

Urology 2020 Jan 9;135:11-19. Epub 2019 Oct 9.

Department of Urology, University of California, San Francisco, San Francisco, CA; Department of Biostatistics and Epidemiology, University of California, San Francisco, San Francisco, CA. Electronic address:

Objective: To elucidate current understanding on the pathophysiological mechanism of genital lichen sclerosus (LS), urologic manifestations, and treatment options.

Materials And Methods: The Medline/PubMed and Embase databases were systematically reviewed for publications pertaining to LS. After applying inclusion and exclusion criteria, references were assessed for relevance to the pathophysiology, presentation, and treatment of LS by title and abstract review by 2 independent reviewers, yielding 186 articles for assessment. Read More

Indian J Dermatol 2019 Sep-Oct;64(5):360-365

Department of Dermatology and Venereology, Pramukhswami Medical College, Karamsad, Gujarat, India.

Context: There is still a dearth of knowledge regarding the types of dermatoses occurring in postmenopausal women. The common disorders occurring in postmenopausal women and the probable effects of hormonal fluctuations on the skin have to be considered while treating postmenopausal women.

Aims: To study clinical patterns of dermatosis in menopausal women. Read More

Acta Dermatovenerol Croat 2019 Sep;27(3):195-197

Ivana Škrinjar, MD, Department of Oral Medicine, University Hospital Center Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia;

Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of genital and extragenital skin (1). Simultaneous involvement of the oral mucosa is extremely rare, but it may be the only affected area (2). A 55-year-old woman was referred to the Department of Oral Medicine, School of Dental Medicine University of Zagreb due to whitish lesions on the right ventrolateral part of the tongue and buccal mucosa with desquamative gingivitis (Figure 1, a-c). Read More

Pediatr Dermatol 2019 Sep;36(5):711-712

Department of Dermatology, University of Rochester Medical Center, Rochester, New York.

Clin Exp Dermatol 2020 Apr 11;45(3):350-352. Epub 2019 Oct 11.

Department of Dermatology, Maggiore Hospital, University of Trieste, Trieste, Italy.

Pediatr Dermatol 2019 Nov 29;36(6):978-979. Epub 2019 Aug 29.

Oral Oncology Center, School of Dentistry, São Paulo State University (UNESP), Araçatuba, Brazil.

Lichen sclerosus is an uncommon chronic inflammatory disease, which rarely affects the oral mucosa. Here, we describe the occurrence of oral lichen sclerosus with gingival destruction in a 12-year-old female patient. After diagnostic confirmation by histopathology, intralesional injection of corticosteroid was performed, producing satisfactory remission of the lesion. Read More

J Pediatr Surg 2020 Apr 13;55(4):721-725. Epub 2019 Aug 13.

Department of Surgery, Alder Hey Children's Hospital NHS Foundation Trust, East Prescott Road, Liverpool, L14 5AB, UK. Electronic address:

Background: Lichen sclerosus (LS), (balanitis xerotica obliterans), causes pathological phimosis. Many boys present with obstructive symptoms, the cause is usually obvious on examination so ultrasound scans (USS) of the urinary tract are not routinely indicated. We review a series of abnormal USS in boys with LS. Read More

Int J Biol Sci 2019 2;15(7):1429-1439. Epub 2019 Jun 2.

Department of Medicine (Division of Genomic Medicine), and Department of Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC.

Lichen sclerosus (LS) is an inflammatory dermatosis with a predilection for anogenital skin. Developing lesions lead to vulvar pain and sexual dysfunction, with a significant loss of structural anatomical architecture, sclerosis, and increased risk of malignancy. Onset may occur at any age in both sexes, but typically affects more females than males, presenting in a bimodal fashion among pre-pubertal children and middle-aged adults. Read More

Acta Derm Venereol 2019 Oct;99(11):953-959

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100730, China.

Wolf's isotopic response refers to the occurrence of a new skin disease at the exact site of an unrelated skin disease that had previously healed. Various cutaneous lesions have been described after herpes zoster. This study included 24 patients with Wolf's isotopic response after herpes zoster infection, which presented as manifestations ranging from inflammatory disease to carcinoma. Read More

J Fam Pract 2019 06;68(5):E8-E10

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, USA.

Clin Exp Dermatol 2020 Jan 5;45(1):127-128. Epub 2019 Jul 5.

Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.

Indian J Sex Transm Dis AIDS 2019 Jan-Jun;40(1):6-12

Department of Skin-VD, Medical College Baroda, SSG Hospital, Vadodara, Gujarat, India.

Lichen sclerosus et atrophicus is an acquired chronic inflammatory dermatosis commonly affecting the vulvar and perianal regions. It is associated with an increased risk of vulvar cancer even though it is not a premalignant condition itself. The true precursor of cancer associated with lichen sclerosus (LS) is vulvar intraepithelial neoplasia (VIN), differentiated type. Read More

Surg Pathol Clin 2019 Jun 5;12(2):249-261. Epub 2019 Apr 5.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, MCN C-3306A, 1161 21st Avenue South, Nashville, TN 37232-2582, USA. Electronic address:

The pathogenesis of vulvar squamous neoplasia has 2 pathways: human papillomavirus (HPV)-dependent and HPV-independent. The HPV-dependent pathway in the vulva follows the same progression as HPV-dependent lesions elsewhere in the gynecologic tract-HPV infection results in high-grade squamous intraepithelial lesion with subsequent progression to basaloid squamous cell carcinoma. The HPV-independent pathway is more complex, with a variety of precursor lesions and molecular alterations. Read More

J Urol 2019 10 6;202(4):748-756. Epub 2019 Sep 6.

Department of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

Purpose: Histopathology can provide insights into disease mechanisms but to date it has been poorly described for urethral stricture. The purpose of this study was to comprehensively describe histopathological findings of stricture specimens obtained at the time of anterior urethroplasty.

Materials And Methods: All pathological specimens of men who underwent anterior urethroplasty of urethral stricture disease from 2010 to 2017 at a single institution were rereviewed by a single blinded pathologist directed to rule out lichen sclerosus and then describe inflammatory cell type and severity when present. Read More

Photodermatol Photoimmunol Photomed 2019 Sep 20;35(5):378-380. Epub 2019 May 20.

Private Practice, Clínica de Vanguardia, Monterrey, México.

Lichen sclerosus (LS) is an uncommon, chronic, lymphocyte-mediated, inflammatory dermatosis characterized by ivory-white patches with scar-like atrophy. Extragenital bullous lichen sclerosus may rarely affect palms and soles, causing severe pain and substantially impairing quality of life. We present the first case of acral bullous lichen sclerosus intolerant to UVA-1 phototherapy successfully treated with low doses of narrowband ultraviolet B phototherapy. Read More

Mov Disord Clin Pract 2019 Apr 4;6(4):316-319. Epub 2019 Apr 4.

Department of Dermatology and Venereology All India Institute of Medical Sciences New Delhi India.

Background: Hemi masticatory spasm (HMS) is a rare movement disorder affecting muscles of mastication attributed to dysfunction of motor branch of trigeminal nerve and is characterized by painful spasm of masticatory muscles. Microvascular compression leading to focal demyelination of motor branch of trigeminal nerve is the most speculated on mechanism of HMS. Treatment options range from medical to surgical approaches, but botulinm toxin (BTX) has now become the preferred treatment. Read More

Dermatol Online J 2019 Apr 15;25(4). Epub 2019 Apr 15.

Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Lagoa Nova - Natal, Rio Grande do Norte.

Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area; oral mucosal lesions are extremely rare. A 52-year-old woman presented for evaluation of an 8-year history of a persistent whitish plaque in the buccal mucosa. Intraoral examination revealed multiple elevated whitish plaques diffusely distributed in the buccal mucosa associated with an area of tissue atrophy. Read More

Acta Dermatovenerol Croat 2019 Mar;27(1):44-46

Sevkiye Copur, MD, Department of Dermatology & Venereology, Istanbul University, Istanbul Medical Faculty , Millet Street (Caddesi), 34093 Capa , Istanbul, Turkey;

Lichen sclerosus (LS), also known as lichen sclerosus et atrophicus, is a chronic inflammatory mucocutaneous disease affecting the genital and/or extragenital areas. Although LS usually occurs alone, its coexistence in morphea patients has been reported in 5.7% and 38. Read More

Urol Int 2019 16;103(4):459-465. Epub 2019 Apr 16.

Department of Human Pathology of Adult and Childhood "Gaetano Barresi", Pediatric Surgery Unit- University of Messina, Messina, Italy,

Background: Lichen sclerosus (LS) is a disease of the skin of unclear etiology that can occur in the foreskin. Topical therapy with corticosteroids is recommended, but they can have side effects.

Objectives: We aimed to compare the effects of ozonides with vitamin E acetate (OZOILE) versus topical corticosteroid in children undergoing circumcision. Read More

Am J Dermatopathol 2019 Jun;41(6):e64-e65

Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL.

Lichen sclerosus (LS) is a chronic inflammatory dermatosis that classically presents as sclerotic, atrophic plaques in the genital region. We present a case of acrochordon with histological features of LS, clinically mimicking intradermal nevus, in a 53-year-old man with no prior history of LS. Our case highlights an unusual morphologic variant of acrochordon and illustrates the role of chronic pressure and occlusion in the development of secondary features of LS. Read More

Cutis 2019 02;103(2):68;79;80

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.

Int J Dermatol 2019 Nov 20;58(11):1311-1316. Epub 2019 Mar 20.

Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil.

Background: Vulvar complaints are among the most frequent causes for a woman to visit a healthcare provider. The diseases of this area of the body may be a challenge to diagnose. In this study, we assess epidemiologic and clinical data of patients in an outpatient vulvar clinic in the dermatology department of a tertiary hospital. Read More

J Urol 2019 06;201(6):1163

Kulkarni Reconstructive Urology Center , Pune , Maharashtra India.

J Urol 2019 06;201(6):1162-1163

Departments of Urology, and Epidemiology and Biostatistics, University of California-San Francisco , San Francisco , California.

J Cosmet Dermatol 2019 Dec 12;18(6):1935-1937. Epub 2019 Mar 12.

Dermatology Unit, NESMOS Department, S. Andrea Hospital, University of Rome "Sapienza", Rome, Italy.

Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory skin disease of unknown etiology. It mainly affects the anogenital area, while the extragenital involvement is uncommon. It manifests as pale, ivory-colored lesions and partially atrophic skin. Read More

J Urol 2019 05;201(5):851

J Urol 2019 06;201(6):1158-1163

Department of Urology, Lahey Hospital and Medical Center , Burlington , Massachusetts.

Purpose: We evaluated the pathophysiology of lichen sclerosus and nonlichen sclerosus urethral stricture disease by comparing protein expression related to inflammation, cell cycle disruption, oxidative stress, hormone receptor status and infection.

Materials And Methods: Tissue samples were collected from the urethral strictures of 81 patients undergoing urethroplasty. Clinical and demographic data were obtained by chart review. Read More

World J Urol 2019 Apr 27;37(4):661-666. Epub 2019 Feb 27.

Department of Surgery, Division of Urology, Sao Paulo Federal University (UNIFESP), São Paulo, Brazil.

Purpose: Evaluate the main etiologies and clinical characteristics of male urethral stricture disease (USD) in Brazil.

Methods: This multicentric study was performed using retrospective data collected from six Brazilian referral centers of urethral reconstruction. The database comprised data from 899 patients with USD who had undergone surgical treatment from 2008 to 2018. Read More

J Urol 2019 03;201(3):431