1,393 results match your criteria Lichen Sclerosus et Atrophicus


Lichen sclerosus et atrophicus and allergic contact dermatitis: A significant association.

J Cosmet Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Dermatology Unit, NESMOS Department, S. Andrea Hospital, University of Rome "Sapienza", Rome, Italy.

Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory skin disease of unknown etiology. It mainly affects the anogenital area, while the extragenital involvement is uncommon. It manifests as pale, ivory-colored lesions and partially atrophic skin. Read More

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http://dx.doi.org/10.1111/jocd.12915DOI Listing
March 2019
1 Read

Insights into the Pathophysiology of Urethral Stricture Disease Due to Lichen Sclerosus: Comparison of Pathological Markers in Lichen Sclerosus Induced Strictures vs Nonlichen Sclerosus Induced Strictures.

J Urol 2019 Feb 8:101097JU0000000000000155. Epub 2019 Feb 8.

Department of Urology, Lahey Hospital and Medical Center , Burlington , Massachusetts.

Purpose: We evaluated the pathophysiology of lichen sclerosus and nonlichen sclerosus urethral stricture disease by comparing protein expression related to inflammation, cell cycle disruption, oxidative stress, hormone receptor status and infection.

Materials And Methods: Tissue samples were collected from the urethral strictures of 81 patients undergoing urethroplasty. Clinical and demographic data were obtained by chart review. Read More

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http://dx.doi.org/10.1097/JU.0000000000000155DOI Listing
February 2019
1 Read

Evaluation of the effectiveness of treatment of vulvar lichen sclerosus et atrophicus. Analysis of own material and review of the literature.

Neuro Endocrinol Lett 2018 Dec;39(5):417-421

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Pl. Starynkiewicza 1-3, 02-015 Warsaw, Poland.

Material And Methods: The study group included eleven female patients aged 18-77 years with a diagnosis of lichen sclerosus. Basic therapy consisted in the application of clobetasol in the first month and then once a day for the following two months. Then, clobetasol was recommended once a week until full resolution of the symptoms. Read More

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December 2018
11 Reads

Medullary sponge kidney and Caroli's disease in a patient with stricture urethra: look for the hidden in presence of the apparent.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Caroli's disease is a rare congenital disorder with incidence rate of approximately 1 in 1 000 000 population. Renal anomalies which may be associated with Caroli's disease include medullary sponge kidney (MSK), cortical cysts, adult recessive polycystic kidney disease and rarely autosomal dominant polycystic kidney disease. Exact incidence of MSK in patients of Caroli's disease is not known. Read More

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http://dx.doi.org/10.1136/bcr-2018-226746DOI Listing
December 2018
5 Reads

Surgical management of genitourinary lichen sclerosus et atrophicus in boys in England: A 10-year review of practices and outcomes.

J Pediatr Urol 2019 Feb 29;15(1):45.e1-45.e5. Epub 2018 Mar 29.

Alder Hey Children's Hospital, Liverpool, UK. Electronic address:

Introduction: Circumcision has long been the mainstay of management for genitourinary lichen sclerosus et atrophicus (LS); however, there has been growing interest in surgical techniques that preserve the foreskin.

Objective: The aim of this study was to assess population-based surgical management of LS in England and determine surgical outcomes.

Study Design: Cases of LS treated in English NHS trusts (2002-2011) were extracted from the Hospital Episode Statistics (HES) Database. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.02.027DOI Listing
February 2019
2 Reads

Lichen sclerosus et atrophicus diagnosed in a child accompanied with local periodontal attachment loss and maxillary deficiency: A rare case report.

J Dermatol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

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http://doi.wiley.com/10.1111/1346-8138.14699
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http://dx.doi.org/10.1111/1346-8138.14699DOI Listing
November 2018
12 Reads

[Scleroatrophic extragenital lichen and inflammatory vitiligo in children: a rare association].

Pan Afr Med J 2018 29;30:75. Epub 2018 May 29.

Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN SINA, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.

Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions evolving over 6 months. Read More

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http://www.panafrican-med-journal.com/content/article/30/75/
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http://dx.doi.org/10.11604/pamj.2018.30.75.13954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191275PMC
October 2018
10 Reads

Extragenital lichen sclerosus et atrophicus within a skin graft scar.

JAAD Case Rep 2018 Oct 10;4(9):938-940. Epub 2018 Oct 10.

Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183025
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http://dx.doi.org/10.1016/j.jdcr.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180244PMC
October 2018
4 Reads

Lichen planus and lichenoid dermatoses: Clinical overview and molecular basis.

J Am Acad Dermatol 2018 Nov;79(5):789-804

St. John's Institute of Dermatology, King's College London, Guy's Hospital, London, United Kingdom.

Deriving from the Greek word λειχήν for "tree moss" and the Latin word planus for "planar," lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically develops in middle-aged adults. Despite the significant clinical burden associated with the disorder, little well-conducted molecular research has been undertaken, possibly because of heterogeneity impeding consistent and confident phenotyping. The multiple variants of lichenoid disease bear overlapping clinical and pathologic features despite manifesting as distinct clinical disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183018
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http://dx.doi.org/10.1016/j.jaad.2018.02.010DOI Listing
November 2018
6 Reads

Scleredema of Buschke associated with lichen sclerosus: Three cases.

Indian J Dermatol Venereol Leprol 2018 Oct 4. Epub 2018 Oct 4.

"Mario Aresu" Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.

Scleredema adultorum of Buschke is a rare fibromucinous, scleroderma-like connective tissue disease most commonly found in a post-infectious setting or linked to hematological disorders or diabetes. Lichen sclerosus et atrophicus is an autoimmune condition only in 2.5% of cases localized exclusively at an extragenital site, occurring in up to 34% of patients in association with other autoimmune diseases such as vitiligo, thyroid disorders, alopecia areata, lichen planus, morphea, pernicious anemia and systemic lupus erythematosus. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_288_17DOI Listing
October 2018
6 Reads

Underestimation of genital lichen sclerosus incidence in boys with phimosis: results from a systematic review.

Pediatr Surg Int 2018 Nov 27;34(11):1245-1250. Epub 2018 Sep 27.

Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital of Chongqing Medical University, No.1617, Riyue avenue, Qinyang District, Chengdu, China.

Purpose: Previous histological studies have shown a variable incidence of genital lichen sclerosus (LS). However, the results of these studies were inconsistent. To overcome the limitation of individual studies, we performed this systematic review to explore the true incidence of LS. Read More

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http://link.springer.com/10.1007/s00383-018-4357-7
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http://dx.doi.org/10.1007/s00383-018-4357-7DOI Listing
November 2018
4 Reads

Mucinous Metaplasia of the Vulva in Zoon Vulvitis and Lichen Sclerosus et Atrophicus. Description of 3 Additional Cases of a Rarely Reported Histopathologic Finding.

Am J Dermatopathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.

Mucinous metaplasia of the vulva (MMV) is a histopathologic finding that has been reported previously in only 3 patients and needs to be distinguished from vulvar extramammary Paget disease. We report 3 additional instances of MMV associated to Zoon vulvitis and vulvar lichen sclerosus et atrophicus. Histochemical and immunohistochemical studies were performed on biopsies from erythematous and erosive vulvar lesions of 3 women aged 64, 80 and 84 years, with features of Zoon vulvitis (2 cases) and lichen sclerosus et atrophicus (1 case). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001277DOI Listing
September 2018
3 Reads

A case of Bullous Pemphigoid Associated with Lichen Sclerosus et Atrophicus.

Indian J Dermatol 2018 Sep-Oct;63(5):427-428

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_127_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124239PMC
September 2018
3 Reads

Dermatoscopy and Reflectance Confocal Microscopy Correlations in Nonmelanocytic Disorders.

Dermatol Clin 2018 Oct 16;36(4):487-501. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via Santa Sofia 78, Catania 95123, Italy.

Dermatoscopy and in vivo reflectance confocal microscopy are noninvasive techniques that provide a horizontal approach, with an en face view of the skin structures. Both techniques assist in the clinical diagnosis of a variety of inflammatory and infectious cutaneous disorders. In many cases, they have shown concordance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183108
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http://dx.doi.org/10.1016/j.det.2018.05.015DOI Listing
October 2018
16 Reads

Dermoscopy of Common Inflammatory Disorders.

Dermatol Clin 2018 Oct 31;36(4):359-368. Epub 2018 Jul 31.

1st Department of Dermatology - Venereology, State Clinic of Dermatology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, 124 Delfon Street, Thessaloniki 54643, Greece. Electronic address:

In addition to its "traditional" application for the early diagnosis of melanoma and nonmelanoma skin cancers, dermoscopy gains appreciation in fields beyond dermato-oncology. Nowadays, dermoscopy has been established as a reliable adjunctive tool to the everyday clinical practice of general dermatology. Morphology and distribution of vascular structures, background colors, follicular abnormalities, and the presence of scales are important features that should be evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.003DOI Listing
October 2018
15 Reads

Childhood Phimosis Secondary to Lichen Sclerosus: Is There a Spatial Pattern of Histopathological Changes?

Am J Dermatopathol 2018 Nov;40(11):824-828

Pediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

Introduction: The accurate histopathological diagnosis of the phimotic prepuce is indispensable because early diagnosis, treatment, and close follow-up are crucial in genital dermatosis such as lichen sclerosus (LS). This study analyzes the histopathological spectrum of childhood phimosis with special emphasis on LS. We also highlight a peculiar pattern of histopathological evolution in LS, prepuce. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001248DOI Listing
November 2018
1 Read

Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation.

Acta Dermatovenerol Alp Pannonica Adriat 2018 Jun;27(2):111-113

Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh, India.

Morphea and lichen sclerosus et atrophicus (LSA) are two diseases that show considerable clinical and histopathological similarity and have been known to coexist in the same patient. Whether the two conditions are different entities or part of the same spectrum has been a topic of debate. This article describes a very rare and interesting case of concomitant morphea and LSA in a 50-year-old female in the same plaque following intramuscular drug injection in the deltoid region of the right arm. Read More

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June 2018
2 Reads

A case of radiation-induced bullous morphea/lichen sclerosus overlap in a breast cancer patient.

Rep Pract Oncol Radiother 2018 Jan-Feb;23(1):47-49. Epub 2017 Dec 26.

Department of Dermatology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Radiation induced morphea (RIM) is an increasingly common complication of radiation treatment for malignancy as early detection has made more patients eligible for non-surgical treatment options. In many cases, the radiation oncologist is the first person to learn of the initial skin changes, often months before a dermatologist sees them. In this paper we present a breast cancer patient who developed a rare bullous variant of RIM, which delayed her diagnosis and subsequent treatment. Read More

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http://dx.doi.org/10.1016/j.rpor.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986578PMC
December 2017
1 Read

Skin and mucous membranes' manifestations of dermatological diseases within the genital area in females.

Postepy Dermatol Alergol 2018 Apr 24;35(2):199-203. Epub 2018 Apr 24.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: (LSA) and an inversed type of psoriasis belong to a group of benign dermatoses usually located within the region of female external genitalia. The most common subjective symptoms reported by patients are itching, pain and changes in the color and structure of the skin.

Aim: This paper presents 3 cases of patients suffering from selected dermatoses located within the external female genitalia treated at the Department of Dermatology, Poznan University of Medical Sciences. Read More

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http://dx.doi.org/10.5114/ada.2018.75243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949551PMC
April 2018
18 Reads

Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath.

Urology 2018 Jul 2;117:e7-e8. Epub 2018 May 2.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Genital lichen sclerosus et atrophicus (LSA) is an uncommon genital dermatosis. Its resemblance to vitiligo, especially during the earlier stages, leads to delay in its diagnosis. Apart from the common complications such as meatal stenosis, balanoposthitis, phimosis, and painful erections, squamous cell carcinoma is a rare but ominous complication of genital LSA. Read More

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http://dx.doi.org/10.1016/j.urology.2018.04.027DOI Listing
July 2018
12 Reads

Hydroxychloroquine retinal toxicity in two patients with dermatological conditions.

Australas J Dermatol 2018 Nov 2;59(4):e266-e268. Epub 2018 May 2.

Melbourne Health, Melbourne, Victoria, Australia.

Two patients with dermatological conditions developed retinal toxicity after treatment with hydroxychloroquine that exceeded dosing recommendations. There is no treatment for hydroxychloroquine retinal toxicity and associated visual loss, so appropriate monitoring is imperative. All members of a patient's multidisciplinary team should be aware of the ocular risks of hydroxychloroquine, the importance of dosing within recommended guidelines and appropriate monitoring in reducing the risk of visual loss. Read More

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http://doi.wiley.com/10.1111/ajd.12827
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http://dx.doi.org/10.1111/ajd.12827DOI Listing
November 2018
2 Reads

Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: Review from a dermatologic perspective.

Photodiagnosis Photodyn Ther 2018 Sep 15;23:119-131. Epub 2018 Apr 15.

University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy.

Photodynamic Therapy is a procedure based on the interaction between a Photosensitizer, a light source with a specific wavelength and oxygen. The aim of this review is to provide a brief and updated analysis of scientific reports on the use of PDT with topical PS in the management of oncological, infectious, and inflammatory disorders involving mucosal and semimucosal areas, with a specific focus on diseases of dermatologic interest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000173046
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http://dx.doi.org/10.1016/j.pdpdt.2018.04.005DOI Listing
September 2018
10 Reads

Lichen sclerosus of the oral mucosa: clinical and histopathological findings. Review of the literature and a case report.

Acta Odontol Scand 2018 Jul 16;76(5):364-373. Epub 2018 Apr 16.

c Head and Neck Center, Oral and Maxillofacial Diseases , Helsinki University Hospital , Helsinki , Finland.

Objectives: Lichen sclerosus (LS) is a rare, chronic mucocutaneous disease that most frequently affects the female genital area. Oral manifestations are seldom detected; only 36 well-documented and histopathologically verified oral LS cases have been published.

Materials And Methods: Here we describe one patient affected by oral (LS) and review of the literature 1957-2017. Read More

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http://dx.doi.org/10.1080/00016357.2018.1463452DOI Listing
July 2018
10 Reads

Genital diseases in the mature woman.

Clin Dermatol 2018 Mar - Apr;36(2):208-221. Epub 2017 Oct 3.

Department of Dermatology, Alpert Medical School of Brown University, Providence, RI; Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil. Electronic address:

Vulvovaginal conditions are common in mature women. This reflects age-related changes in immunity and skin barrier function of vulvovaginal tissues. Vaginal atrophy is commonly complicated by dryness and inflammation, which makes postmenopausal atrophic vaginitis a virtually ubiquitous condition. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.012DOI Listing
September 2018
9 Reads

Genital diseases in the mature man.

Clin Dermatol 2018 Mar - Apr;36(2):197-207. Epub 2017 Oct 4.

Department of Dermatology, University College Hospital, London, UK.

Elderly men are at higher risk of developing genital dermatologic problems, including inflammatory and neoplastic conditions due to age-related physiologic changes, immunosenescence, comorbidities, and iatrogenesis. Clinical manifestations of genital dermatoses in men are varied and may include itching, pain, redness, dermatitis, lumps, and ulcers. Even when asymptomatic, the psychologic impact may be significant. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.011DOI Listing
September 2018
7 Reads

Blue diode laser: a new strategy for the management of lichen sclerosus et atrophicus.

G Ital Dermatol Venereol 2018 Apr;153(2):289-291

Department of Dermatology and Venereology, University of Trieste, Trieste, Italy.

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http://dx.doi.org/10.23736/S0392-0488.17.05506-7DOI Listing
April 2018
11 Reads
0.490 Impact Factor

Double Opposing Zplasty with VY Advancement of the perineum: Long-term results of a new technique as an alternative to Fenton's operation for narrowing and splitting of the skin at the posterior vaginal fourchette.

Eur J Obstet Gynecol Reprod Biol 2018 Apr 9;223:46-49. Epub 2018 Feb 9.

Depts. of Obstetrics and Gynaecology and Plastic Surgery, Derriford Hospital, Plymouth, UK. Electronic address:

Objective: To assess the long-term results of our experience with this technique which we have developed as an alternative to Fenton's procedure.

Study Design: A retrospective questionnaire study of all patients undergoing the procedure in our department from Jan. 2006 to Dec. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.02.003DOI Listing
April 2018
12 Reads

Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?

J Low Genit Tract Dis 2018 Apr;22(2):159-165

Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.

Objective: The aim of the study was to assess for the presence of vulvar lichen planus (LP) in association with human papillomavirus (HPV)-independent squamous cell carcinoma (SCC).

Materials And Methods: We performed a clinicohistopathologic review of consecutive vulvectomies and wide local excisions for HPV-independent vulvar or vaginal SCC from 2007 to 2017. Data collected included site of SCC, adjacent precursor lesions and dermatoses, dermatologic treatment, and outcome. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895143PMC
April 2018
5 Reads

Human papillomavirus infection and lichen sclerosus: coincidence or link?

Int J Dermatol 2018 05 19;57(5):617-618. Epub 2018 Feb 19.

Dermatology Clinic, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1111/ijd.13933DOI Listing
May 2018
5 Reads

Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis.

Skin Res Technol 2018 Aug 18;24(3):499-503. Epub 2018 Feb 18.

Dermatology Clinic, University of Catania, Catania, Italy.

Background: The term balanitis includes a variety of inflammatory skin diseases involving the glans penis whose clinical diagnosis may be challenging. A biopsy is often required to obtain a definitive diagnosis, although it is barely accepted by patients. Reflectance confocal microscopy (RCM), that provides a real-time, en face imaging of the epidermis and upper dermis, is currently utilized for the diagnosis of some neoplastic and inflammatory skin diseases. Read More

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http://dx.doi.org/10.1111/srt.12460DOI Listing
August 2018
5 Reads

Linear orofacial lichen sclerosus.

Indian J Dermatol Venereol Leprol 2018;84(2):197-199

Department of Dermatological, Dermatology Hospital, Southern Medical University, Guangdong Povincial Dermatology Hospital, Guangzhou, China.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_856_16DOI Listing
November 2018
2 Reads

Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review.

J Pediatr Surg 2018 Nov 3;53(11):2225-2227. Epub 2018 Jan 3.

Department of Surgery, Alder Hey Children's Hospital, Liverpool, UK; University of Liverpool, Liverpool, United Kingdom. Electronic address:

Purpose: To determine whether treatment of lichen sclerosus et atrophicus (LS), with topical steroids reduces the rate of circumcision.

Methods: Two independent reviewers performed a literature search of studies reporting treatment of LS with topical steroids using EMBASE and MEDLINE database(s).

Inclusion Criteria: boys aged 0-18 years, clinical diagnosis of LS, treatment with topical steroids. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.12.021DOI Listing
November 2018
13 Reads

MiR-155-5p promotes fibroblast cell proliferation and inhibits FOXO signaling pathway in vulvar lichen sclerosis by targeting FOXO3 and CDKN1B.

Gene 2018 May 12;653:43-50. Epub 2018 Jan 12.

Department of Gynecology and Obstetrics, The First Affiliated Hospital of China Medical University, Liaoning 110001, China. Electronic address:

Vulvar lichen sclerosis (VLS) is a chronic inflammatory skin disorder. Evidence is accumulating that microRNAs (miRNAs) exert crucial roles in initiation and development of a wide range of human diseases. MiR-155-5p has been frequently reported to be implicated in the tumorigenesis and progression of multiple types of cancers, however, its biological role in VLS remains unclear. Read More

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http://dx.doi.org/10.1016/j.gene.2018.01.049DOI Listing
May 2018
5 Reads

Skin mapping for the classification of generalized morphea.

J Am Acad Dermatol 2018 02;78(2):351-357

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Background: Generalized morphea lacks cohesive clinical features, limiting its clinical and investigative utility.

Objective: We sought to use computerized lesion mapping to objectively subtype morphea.

Methods: We conducted a 2-part cross-sectional study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622163073
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http://dx.doi.org/10.1016/j.jaad.2016.08.052DOI Listing
February 2018
11 Reads

Vitiligoid variant of lichen sclerosus in young girls with darker skin types.

Pediatr Dermatol 2018 Mar 4;35(2):198-201. Epub 2018 Jan 4.

Section of Dermatology, University of Chicago, Chicago, IL, USA.

Background/objectives: Vitiligo and lichen sclerosus are autoimmune disorders characterized by white discoloration, and both frequently affect the anogenital region. Vitiligoid lichen sclerosus refers to a superficial variant of lichen sclerosus in which the lesion appears clinically to be vitiligo based on the predominant presentation of depigmentation and minimal inflammation and sclerosis but histologically is consistent with lichen sclerosus. A limited number of reports have described vitiligoid lichen sclerosus, and from these reports, it appears to primarily affect darker-skinned people. Read More

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http://dx.doi.org/10.1111/pde.13399DOI Listing
March 2018
3 Reads

Oral lichen sclerosus: a systematic review of reported cases and two new cases.

Int J Dermatol 2018 May 4;57(5):521-528. Epub 2018 Jan 4.

Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.

Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque-like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. Read More

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http://dx.doi.org/10.1111/ijd.13870DOI Listing
May 2018
2 Reads

Penile Lichen Sclerosus Treated with 1927 nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach.

Photomed Laser Surg 2018 Jun 3;36(6):333-336. Epub 2018 Jan 3.

3 Department of Health Sciences, University of Catanzaro , Catanzaro, Italy .

Objective: We treated two patients with recalcitrant lichen sclerosus (LS) of the penis with a combination of 1927 nm thulium fiber laser and methyl-aminolevulinate (MAL) photodynamic therapy (PDT).

Background Data: Therapy of LS is based on topical potent steroids, emollients, and topical calcineurin inhibitors. Circumcision is effective, but not always accepted. Read More

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http://dx.doi.org/10.1089/pho.2017.4386DOI Listing
June 2018
9 Reads

Diagnostic criteria, severity classification and guidelines of lichen sclerosus et atrophicus.

J Dermatol 2018 Aug 19;45(8):891-897. Epub 2017 Dec 19.

Department of Molecular Pathology of Skin, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

We established diagnostic criteria and severity classification of lichen sclerosus et atrophicus, because there is no established diagnostic criteria or widely accepted severity classification of the disease. Also, there is no clinical guideline for lichen sclerosus et atrophicus in Japan, so we proposed its clinical guideline. The clinical guidelines were formulated by clinical questions and recommendations on the basis of evidence-based medicine according to the New Minds Clinical Practice Guideline Creation Manual (version 1. Read More

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http://dx.doi.org/10.1111/1346-8138.14171DOI Listing
August 2018
29 Reads

5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases.

Photodiagnosis Photodyn Ther 2018 Mar 16;21:234-238. Epub 2017 Dec 16.

Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address:

Background: Vulvar lichen sclerosus et atrophicus (VLSA) is a chronic inflammatory skin disease of unknown etiology that mainly affects postmenopausal and perimenopausal women. The primary clinical symptoms of VLSA are itching, burning pain, and dyspareunia that can results in decreased quality of life. Existing therapies including topical corticosteroid ointment, topical calcineurin inhibitors, estrogens, are not very effective for treatment of VLSA. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922423PMC
March 2018
14 Reads

Dermoscopy of Morphea and Cutaneous Lichen Sclerosus: Clinicopathological Correlation Study and Comparative Analysis.

Dermatology 2017 14;233(6):462-470. Epub 2017 Dec 14.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Background: Dermoscopy of morphea and cutaneous lichen sclerosus (CLS) has been described by various studies, with none of them considering variability according to clinical phases and investigating dermoscopic-histological correlations.

Objective: To evaluate dermoscopic features in general and according to clinical stage, identify possible distinctive dermoscopic clues, and assess dermoscopy accuracy in detecting subclinical alterations in morphea and CLS.

Methods: A representative dermoscopic image of target lesions was evaluated for the presence of specific features, correlating them with clinical subtype (inflammatory, inflammatory-sclerotic, sclerotic, or sclerotic-atrophic). Read More

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http://dx.doi.org/10.1159/000484947DOI Listing
October 2018
21 Reads

Vulvar lichen planus pemphigoides.

Authors:
J Loyal S Rashtak

Int J Womens Dermatol 2017 Dec 20;3(4):225-227. Epub 2017 Aug 20.

Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH.

Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. Read More

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http://dx.doi.org/10.1016/j.ijwd.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715214PMC
December 2017
21 Reads

Extramammary Paget's Disease Associated With Genital Wart and Lichen Sclerosus.

Acta Med Iran 2017 Sep;55(9):591-593

Department of Pathology, NYU Winthrop Hospital, Mineola, NY, USA.

Extramammary Paget's disease is an uncommon intraepithelial adenocarcinoma in genital and perianal regions. Genital wart is the most common sexually transmitted disease caused by human papilloma viruses and vulval lichen sclerosus is chronic pruritic dermatitis in genital area which could be able to change to invasive squamous cell carcinoma. We report a patient who had simultaneous lichen sclerosus, genital wart and extramammary Paget's disease of the vulva. Read More

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September 2017
8 Reads

Squamous Cell Carcinoma of the Bulbar Urethra Accompanied by Lichen Sclerosus: A Case Report.

Am J Mens Health 2018 03 28;12(2):493-497. Epub 2017 Nov 28.

1 Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Squamous cell carcinoma (SCC) of the bulbar urethra accompanied by lichen sclerosus (LS) is rarely reported. This study reports the case of a 56-year-old man with urethral squamous cell carcinoma (USCC) accompanied by a long history of genital LS. The man presented with a painful perineal mass and had a long-term history of urethral strictures and urethral dilatation. Read More

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http://dx.doi.org/10.1177/1557988317743386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818129PMC
March 2018
8 Reads

Staged Urethroplasty for Penile Urethral Strictures From Lichen Sclerosus and Failed Hypospadias Repair.

Urology 2018 Feb 26;112:222-224. Epub 2017 Oct 26.

Thomas Jefferson University School of Medicine, Philadelphia, PA.

Objective: To present our technique for staged urethroplasty with buccal mucosa graft.

Methods: The patient presented is a 42-year-old man with a history of congenital hypospadias repaired as a child. He developed a penile urethral stricture at age 30 and was managed with self-intermittent dilation. Read More

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http://dx.doi.org/10.1016/j.urology.2017.10.020DOI Listing
February 2018
3 Reads

Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination.

Actas Dermosifiliogr 2018 Jan - Feb;109(1):86-88. Epub 2017 Oct 10.

Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, España.

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http://dx.doi.org/10.1016/j.ad.2017.05.016DOI Listing
September 2018
1 Read

A survey on the use of topical steroids in patients treated for lichen sclerosus-associated vulval squamous cell carcinoma.

J Obstet Gynaecol 2018 Feb 10;38(2):265-269. Epub 2017 Oct 10.

c Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , United Kingdom.

Evidence suggests that lichen sclerosus (LS) is the primary aetiological factor for local vulval recurrence (LVR) in vulval squamous cell carcinoma (VSCC). The long-term application of topical corticosteroids is believed to prevent LVR. Patients treated for LS-associated VSCC at a gynaecological cancer centre were invited to complete a questionnaire to evaluate whether they are receiving corticosteroids. Read More

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http://dx.doi.org/10.1080/01443615.2017.1352572DOI Listing
February 2018
32 Reads

Folliculocentric hyperkeratotic lichen sclerosus in a 7-year-old child successfully treated with narrowband ultraviolet B phototherapy.

Clin Exp Dermatol 2018 Jan 20;43(1):91-93. Epub 2017 Sep 20.

Department of Dermatology, Istanbul Medeniyet University Medical Faculty, Goztepe Research and Training Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1111/ced.13216DOI Listing
January 2018

Penile Melanosis Associated with Lichen Sclerosus et Atrophicus: First Description in the Medical Literature.

Open Access Maced J Med Sci 2017 Aug 10;5(5):692-693. Epub 2017 Aug 10.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, Generel Skobelev 79, 1606 Sofia, Bulgaria.

We present a 74-year-old male patient with 3-years history of visible discoloration of the glans penis, without subjective complaints. Histopathological examination after incision biopsy revealed a moderate increase in the number of melanocytes in the basal layer with irregular distribution, without melanocytic nests, melanophages in the superficial dermis, and subepidermal sclerosus. No cytologic atypia of melanocytes was detectable. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2017.152
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http://dx.doi.org/10.3889/oamjms.2017.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591605PMC
August 2017
16 Reads