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    1317 results match your criteria Lichen Sclerosus et Atrophicus

    1 OF 27

    Penile Melanosis Associated with Lichen Sclerosus et Atrophicus: First Description in the Medical Literature.
    Open Access Maced J Med Sci 2017 Aug 10;5(5):692-693. Epub 2017 Aug 10.
    Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, Generel Skobelev 79, 1606 Sofia, Bulgaria.
    We present a 74-year-old male patient with 3-years history of visible discoloration of the glans penis, without subjective complaints. Histopathological examination after incision biopsy revealed a moderate increase in the number of melanocytes in the basal layer with irregular distribution, without melanocytic nests, melanophages in the superficial dermis, and subepidermal sclerosus. No cytologic atypia of melanocytes was detectable. Read More

    [Plastic surgery reconstruction of the adult buried penis : Option or obligation?]
    Urologe A 2017 Oct;56(10):1266-1273
    Klinik für Plastische und Ästhetische Chirurgie - Handchirurgie - Wiederherstellungschirurgie, St. Antonius-Hospital Eschweiler, Aachen, Deutschland.
    The adult buried penis afflicts the patient with shame and is also potentially associated with considerable urogenital complications. Due to obesity, chronic urogenital lymphedema or subsequent inflammatory urogenital conditions, such as a lichen sclerosus et atrophicus, the clinical appearance of the adult buried penis is extremely variable. Epidemiological data are non-existent. Read More

    Vulvar Lichen Sclerosus et Atrophicus.
    J Midlife Health 2017 Apr-Jun;8(2):55-62
    Department of Dermatology and Venereology, Pramukshwami Medical College, Karamsad, Gujarat, India.
    Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-white plaques or patches with glistening surface commonly affecting the vulva and anus. Common symptoms are irritation, soreness, dyspareunia, dysuria, and urinary or fecal incontinence. Anogenital lichen sclerosus (LS) is characterized by porcelain-white atrophic plaques, which may become confluent extending around the vulval and perianal skin in a figure of eight configuration. Read More

    Lichen sclerosus et atrophicus: atypical case simulating lichen planus.
    Dermatol Online J 2017 06 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, Hospital Santa Casa de Curitiba, Curitiba, Paraná, Brazil.
    Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatosis, characterized by shiny, atrophic, hypochromic papules with a predilection for the genital and perineal skin. Extragenital involvement may occur, but is rare in the isolated form. LSA more commonly affects prepubertal and postmenopausal women. Read More

    Presentations, Signs of Activity, and Differential Diagnosis of Vitiligo.
    Dermatol Clin 2017 Apr;35(2):135-144
    Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9069, USA. Electronic address:
    Vitiligo has a variety of presentations, including focal, acrofacial, segmental, and generalized forms. Thorough knowledge of these presentations is important to make the correct diagnosis. Signs of activity are important to recognize so that treatment is optimized. Read More

    Quality of Life, Burden of Disease, Co-morbidities, and Systemic Effects in Vitiligo Patients.
    Dermatol Clin 2017 Apr;35(2):117-128
    Department of Dermatology, EpiDermE, Henri Mondor Hospital, Université Paris-Est Créteil Val-de-Marne, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France.
    Vitiligo is a complex, systemic disease associated with many autoimmune and autoinflammatory conditions. Additionally, the cutaneous changes of vitiligo have significant effects on quality of life and self-esteem. Further efforts are needed to increase our understanding of vitiligo comorbidities as well as to increase awareness of the psychological effects of vitiligo. Read More

    Extensive bullous lichen sclerosus et atrophicus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):81-83
    Clinical Center of Serbia, Faculty of Medicine, University of Belgrade - Belgrade, Serbia.
    Lichen sclerosus et atrophicus is a chronic disease of unknown etiology characterized by atrophic and sclerotic plaques in both genital and extragenital regions. Extensive bullous lichen sclerosus et atrophicus (BLSA) is a severe variant of the disease with no widely accepted treatment. We present a 63-year-old woman with extensive extragenital, ivory-colored, atrophic plaques on her trunk and extremities and disseminated hemorrhagic bullae. Read More

    [Extragenital lichen sclerosus et atrophicus: about a case].
    Pan Afr Med J 2016 24;25:190. Epub 2016 Nov 24.
    Service de Dermatologie, CHU Ibn Sina Rabat, Maroc.
    Lichen sclerosus et atrophicus is a chronic inflammatory dermatosis, characterized by a specific external genital mucosal tissue tropism. Isolated cutaneous manifestation is rare. We report a case of lichen sclerosus et atrophicus in a woman with purely cutaneous involvement, in order to highlight the importance of evoking this diagnosis in the absence of obvious genital involvement. Read More

    Intermediate-Term Outcomes and Complications of Long Segment Urethroplasty with Lingual Mucosa Grafts.
    J Urol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital and Shanghai Eastern Urological Reconstruction and Repair Institute, Shanghai, China; Department of Urology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
    Purpose: We evaluated outcomes and donor site complications in male patients with complex urethral strictures who underwent urethroplasty using with long strip oral mucosal grafts. We also analyzed whether a lingual mucosa graft is a good substitute for repairing long segment urethral strictures.

    Materials And Methods: This retrospective study was done in 81 male patients with complex urethral strictures who underwent oral mucosal graft urethroplasty. Read More

    The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic.
    Br J Dermatol 2017 Feb;176(2):307-316
    St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, U.K.
    Lichen sclerosus is one of the dermatoses that specifically affects the anogenital skin. It has peaks of incidence in prepubertal girls and postmenopausal women. The objective of this critical appraisal was to review systematically the evidence for efficacy and safety of different treatments. Read More

    Silk textile with antimicrobial AEM5772/5 (Dermasilk): a pilot study with positive influence on acne vulgaris on the back.
    Int J Dermatol 2017 May 27;56(5):589-591. Epub 2017 Feb 27.
    Center of Aesthetic Medicine, Department of Dermatology, Medical University Graz, Graz, Austria.
    Background: The use of special silk textiles (Dermasilk) has shown positive effects on chronic inflammatory diseases like lichen sclerosus et atrophicus, atopic dermatitis, diabetic ulcerations, and vulvovaginal candidiasis.

    Objective: Wearing T-shirts of this particular fabric could be useful in the management of patients with acne vulgaris on the back and trunk.

    Material And Methods: Dermasilk T-shirts were given to 14 patients with acne vulgaris papulopustulosa on the back. Read More

    Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life.
    Int Urol Nephrol 2017 Apr 4;49(4):573-580. Epub 2017 Feb 4.
    Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Via De Toni 16, 16132, Genoa, Italy.
    Purpose: Lichen sclerosus (LS) is a chronic inflammatory skin condition that frequently involves the anogenital region. Ongoing research is focused on finding more effective treatments for tissue repair and reducing symptoms. The aim of this study is to evaluate the effectiveness of platelet-rich plasma (PRP) local injections in penile LS. Read More

    Lichen sclerosus and risk of cancer.
    Int J Cancer 2017 May 10;140(9):1998-2002. Epub 2017 Feb 10.
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
    Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection. We identified all women with the diagnosis of LS (n = 7,616) listed in the Finnish Hospital Discharge Registry from 1970 to 2012. Read More

    Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans).
    J Pediatr Urol 2017 Apr 9;13(2):208.e1-208.e4. Epub 2016 Dec 9.
    Alder Hey Children's NHS Foundation Trust, Department of Paediatric Surgery, E Prescot Rd, Liverpool, L14 5AB, UK.
    Introduction: Over 27,000 circumcisions were performed in England in 2012-13. The complication rate is generally perceived to be low, although published figures vary widely. Balanitis xerotica obliterans, more correctly termed Lichen Sclerosus et atrophicus (LS), is one of the commonest indications for medical circumcision. Read More

    Lichen sclerosus et atrophicus in a surgical scar treated with fractional laser.
    J Cosmet Laser Ther 2017 Apr 2;19(2):106-108. Epub 2017 Feb 2.
    a Dermatology Department , Clínica Dermitek , Bilbao , Spain.
    Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease of unknown cause that typically affects the genital area (1). It has been reported in post-traumatic areas as a result of Koebner phenomenon. LSA responds poorly to treatment making it a therapeutic challenge (2). Read More

    Effect of Lichen Sclerosis on Success of Urethroplasty.
    Urol Clin North Am 2017 Feb;44(1):77-86
    Division of Urology, Department of Surgery, Duke University Medical Center, DUMC 3146, Durham, NC 27710, USA.
    Lichen sclerosis (LS) is a chronic, relapsing disease with a variable presentation. In men, genitourinary LS may affect the penile foreskin, glans, meatus, and urethra. Treatment is multifaceted, ranging from pharmacotherapy to surgery. Read More

    HPV status and favourable outcome in vulvar squamous cancer.
    Int J Cancer 2017 Mar;140(5):1134-1146
    MRC-University of Glasgow Centre for Virus Research, University of Glasgow.
    It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently, it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. Read More

    Histopathological and clinical traps in lichen sclerosus: a case report.
    Rom J Morphol Embryol 2016 ;57(2 Suppl):817-823
    Department of Ophthalmology, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania;
    Lichen sclerosus et atrophicus and limited systemic scleroderma (acrosclerosis) are inflammatory skin diseases that ultimately evolve into two distinct modes of atrophic scar formation, but which can easily be confused clinically. They are very rarely associated. The literature has reported cases in which lichen sclerosus was associated with various forms of scleroderma, but often with localized morphea. Read More

    [Nomenclature of squamous cell precursor lesions of the lower female genital tract : Current aspects].
    Pathologe 2016 Nov;37(6):526-533
    Institut für Pathologie, Abteilung Mamma-, Gynäko- und Perinatalpathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland.
    The majority of precancerous lesions of the lower female genital tract (intraepithelial neoplasia, IN) are caused by human papillomavirus (HPV) infections resulting in cellular atypia and in turn an altered tissue architecture. Depending on the pathogenesis, a distinction is made between vulvar intraepithelial neoplasia (VIN) classified as classical VIN associated with high-risk HPV infections (u-VIN) and differentiated VIN (d-VIN), which is associated with lichen sclerosus et atrophicus and p53 alterations. In the current World Health Organization (WHO) classification a novel grading system for squamous cell precancerous lesions of the lower female genital tract has been proposed, differentiating low grade squamous intraepithelial lesions (L-SIL) including condyloma and HPV-associated alterations plus VIN 1, vaginal intraepithelial neoplasia (VaIN 1) and cervical intraepithelial neoplasia (CIN 1) from high grade squamous intraepithelial lesions (H-SIL) with VIN 2 and 3, VaIN 2 and 3 as well as CIN 2 and 3. Read More

    Phototherapy for sclerosing skin conditions.
    Clin Dermatol 2016 Sep-Oct;34(5):614-22. Epub 2016 May 20.
    Department of Dermatology, University of Texas at Southwestern Medical Center, Dallas, TX. Electronic address:
    Phototherapy is an effective treatment strategy for a variety of sclerosing skin conditions. There are a number of phototherapeutic modalities used for the treatment of sclerosing skin conditions, including ultraviolet (UV)A1, broadband UVA, psoralen plus UVA, and narrowband UVB phototherapy. As controlled trials with validated outcome measures are lacking for these therapies, existing evidence is largely level II for morphea and is even more minimal for scleroderma and other sclerosing disorders (scleroderma, lichen sclerosus, and chronic graft-versus-host disease, among others). Read More

    Polydeoxyribonucleotide Treatment in Genital Lichen Sclerosus in Males.
    Urol Int 2017 13;98(1):111. Epub 2016 Sep 13.
    Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Unit of Paediatric Surgery, University of Messina, Messina, Italy.
    It has been reported that treatment with polydeoxyribonucleotide (PDRN) in males affected by lichen sclerosus significantly improves the overall conditions of treated patients. It confirms that PDRN has a potent cytoprotective action as in other pathological conditions. We believe that multicentric randomized clinical trials are necessary for testing the benefits of this promising agent. Read More

    Female lichen sclerosus genitalis: discomfort and adaptation.
    Clin Ter 2016 Jul-Aug;167(4):113-20
    Department of Mental and Physical Health and Preventive Medicine Faculty of Medicine and Surgery, Second University of Naples.
    Introduction: Female genitalis lichen sclerosus (FGLS) occurs on skin and mucous membranes and shows inflammatory lesions, chronic atrophic, itching and pain. These physical damages produce a decline in sex and a resulting relational couple discomfort.

    Aim: We describe the discomfort and the relationship between physical and psychological damage. Read More

    Lichen sclerosus associated with localized scleroderma: dermoscopy contribution.
    An Bras Dermatol 2016 Jul-Aug;91(4):534-6
    Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
    Lichen sclerosus is an uncommon inflammatory dermatosis with preferential involvement of the urogenital region. The extragenital involvement is uncommon and is characterized by small rounded macules or papules, pearly white in color. The coexistence of lichen sclerosus and scleroderma plaques in most cases with extragenital location has been reported in the literature. Read More

    New insights into potential risk factors and associations in genital lichen sclerosus: Data from a multicentre Italian study on 729 consecutive cases.
    J Eur Acad Dermatol Venereol 2017 Apr 12;31(4):699-704. Epub 2016 Aug 12.
    Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive, Università degli Studi di Ferrara, Ferrara, Italy.
    Background: Limited data are available on risk factors associated with lichen sclerosus and no data are available on gender differences in genital lichen sclerosus (GLS).

    Objective: This multicentre study aimed at identifying potential risk factors for GLS, through data collection from a large, mixed-sex sample of patients comparing gender-related differences in relation to data from the general population.

    Methods: This was a cross-sectional study on 729 subjects (53. Read More

    Effects of Intravenous Ketamine Infusions in a Neuropathic Pain Patient with Lichen Sclerosus et Atrophicus.
    Case Rep Dermatol 2016 May-Aug;8(2):164-70. Epub 2016 Jun 6.
    Florida Spine Institute, Clearwater, Fla., USA.
    A patient reported to the Florida Spine Institute (Clearwater, Fla., USA) with severe lichen sclerosus of the anogenital region and legs. The patient's pain presentation was neuropathic with hypersensitivity, allodynia, swelling, and weakness. Read More

    Folliculocentric Lichen Sclerosus et Atrophicus in a 10-Year-Old Girl.
    Am J Dermatopathol 2017 Jan;39(1):59-61
    *Departments of Pathology, and †Dermatology, Wake Forest School of Medicine, Winston Salem, NC.
    Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory scarring disease with a predilection for the anogenital area; however, 15%-20% of LSA cases are extragenital. The folliculocentric variant is rarely reported and less well understood. The authors report a rare case of extragenital, folliculocentric LSA in a 10-year-old girl. Read More

    Adjacent Lichen Sclerosis predicts local recurrence and second field tumour in women with vulvar squamous cell carcinoma.
    Gynecol Oncol 2016 09 7;142(3):420-6. Epub 2016 Jul 7.
    Institute of Cancer and Genomic Sciences, College of Dental and Medical School, University of Birmingham, Edgbaston B15 2TT, United Kingdom. Electronic address:
    Objective: In this study, we investigated if the presence of histologically abnormal epithelium adjacent to the primary tumour influenced the frequency, timing, and topography of local vulvar recurrences (LVR) following treatment for squamous cell carcinoma of the vulva (VSCC).

    Methods: The study population comprised a cohort of 201 consecutive cases with incident VSCC. LVR were categorised as local relapses (LR) if they occurred <2cm from the tumour margins, and as second field tumours (SFT) when ≥2cm from these margins. Read More

    Annular Lichenoid Dermatitis (of Youth) Immunohistochemical and Serological Evidence for Another Clinical Presentation of Borrelia Infection in Patients of Western Austria.
    Am J Dermatopathol 2017 Mar;39(3):177-180
    *Private Dermatohistological Laboratory, Nuernberg, Germany; †Institute of Pathology, Medical University Innsbruck, Innsbruck, Austria; ‡Private Pathological Laboratory, Salzburg, Austria; and §Clinical Department of Dermatology & Venereology, Medical University Innsbruck, Innsbruck, Austria.
    Annular lichenoid dermatitis of youth (ALDY) is a more recently described inflammatory disease of the skin of unknown etiology with clinical similarities to morphea. The authors clinically, histopathologically, and immunohistochemically investigated 14 biopsies from 12 patients in western Austria with this disease. There were 6 female and 6 male patients with solitary (n = 7) and multiple lesions (n = 5) affecting the trunk (n = 11), upper arm (n = 2), thigh (n = 1), and calf (n = 1). Read More

    [Dermatological diseases of the external male genitalia : Part 1].
    Urologe A 2016 Jun;55(6):829-42
    Gemeinschaftspraxis für Dermatologie und Urologie, Gießen, Deutschland.
    The urological examination of male patients includes an inspection of the external genitalia whereby a variety of dermatological alterations can be found. Not all dermatological findings are of clinical relevance. Pearly penile papules and heterotopic sebaceous glands are examples of normal physiological variations. Read More

    Lichen sclerosis: clinicopathological study of 60 cases from Lebanon.
    Int J Dermatol 2016 Oct 27;55(10):1076-81. Epub 2016 May 27.
    Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
    Background: Lichen sclerosus (LS) is an uncommon idiopathic chronic inflammatory debilitating disease with predilection for the genital region. Our recent encounter with an LS case exhibiting perineural inflammation microscopically prompted us to assess the features of all patients diagnosed with LS at our institution.

    Materials And Methods: All cases of LS diagnosed between 1990 and 2014 were retrospectively reviewed. Read More

    Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus.
    J Eur Acad Dermatol Venereol 2017 Feb 27;31(2):e81-e83. Epub 2016 May 27.
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

    Hypermethylation-Induced Inactivation of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus.
    JAMA Dermatol 2016 Aug;152(8):928-33
    Section of Pathology, Oncology, and Experimental Biology, Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    Importance: The molecular mechanism leading to the development of vulvar squamous cell carcinoma (VSCC) from vulvar lichen sclerosus (VLS) is unknown.

    Objective: To assess the possible involvement of the IRF6 tumor-suppressor gene in the development of VSCC from VLS.

    Design: In laboratories at the University of Ferrara, Ferrara, Italy, IRF6 gene expression and promoter methylation were investigated in paraffin-embedded VSCC and adjacent vulvar intraepithelial neoplasia (VIN) and VLS specimens, in cancer-free VLS (cfVLS) specimens, and in healthy skin specimens by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) analysis and by sequencing of PCR-amplified bisulfite-treated DNA. Read More

    Diversity of patient profile, urethral stricture, and other disease manifestations in a cohort of adult men with lichen sclerosus.
    Investig Clin Urol 2016 05 10;57(3):202-7. Epub 2016 May 10.
    Department of Urology, University of Michigan, Ann Arbor, MI, USA.
    Purpose: Lichen sclerosus (LS) in men is poorly understood. Though uncommon, it is often severe and leads to repeated surgical interventions and deterioration in quality of life. We highlight variability in disease presentation, diagnosis, and patient factors in male LS patients evaluated at a tertiary care center. Read More

    Gorlin Syndrome, Vulvar Basal Cell Carcinomas, Vismodegib, and Lichen Sclerosus: From the ISSVD Case Consultation Committee.
    J Low Genit Tract Dis 2016 Jul;20(3):e40-1
    1Maternity and Gynaecology, John Hunter Hospital, New Lambton, New South Wales; 2Obstetrician and Gynaecologist, East Melbourne, Victoria; and 3Anatomical Pathology, Pathology North, Hunter New England, New Lambton, New South Wales; and Faculty of Medicine and Health, University of Newcastle, Callaghan, New South Wales, Australia.

    Georgian Med News 2016 Feb(251):58-64
    1Department "Medicinal Information and Non-interventional studies", Bulgarian Drug Agency, Sofia, Bulgaria; 2"Onkoderma"- Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; 3Department of General and Clinical Pathology, Medical Faculty, "Saint Kliment Ohridski University"; 4Dermatology Department, University Hospital of Coimbra, Praceta Mota Pinto, Portugal; 5Department of General and Clinical pathology, Medical University of Plovdiv, Bulgaria; 6Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
    We describe a rare case of a 28 year-old male patient presenting with pruritus and increased sensitivity of the prepuce accompanied by erythematous confluent papules, unilateral nevus flammeus (NF) along almost the whole length of the right lower limb and two dysplastic nevi (DN), one located on the mid back and the other on the medial border of the right fifth toe, the latter coinciding with the NF. A biopsy of the prepuce revealed lichen sclerosus et atrophicus (LSA). Mental health assessment revealed anxiety disorder and predisposition to panic attacks. Read More

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