9,928 results match your criteria Lichen Planus


PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus - A pilot study.

Indian J Dent Res 2020 Mar-Apr;31(2):277-281

Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M S Ramaiah University of Applied Sciences, M S R Nagar, Bangalore, Karnataka, India.

Context: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion molecules (VAMs). Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_653_18DOI Listing

Microbial Community Analysis of Saliva and Biopsies in Patients With Oral Lichen Planus.

Front Microbiol 2020 5;11:629. Epub 2020 May 5.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

The specific etiology and pathogenesis of oral lichen planus (OLP) remain elusive, and microbial dysbiosis may play an important role in OLP. We evaluated the saliva and tissue bacterial community of patients with OLP and identified the colonization of bacteria in OLP tissues. The saliva ( = 60) and tissue ( = 24) samples from OLP patients and the healthy controls were characterized by 16S rDNA gene sequencing and the bacterial signals in OLP tissues were detected by fluorescence hybridization (FISH) targeting the bacterial 16S rDNA gene. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219021PMC

Is oral lichen planus a risk factor for peri-implant diseases? A systematic review and meta-analysis.

BMC Oral Health 2020 May 20;20(1):150. Epub 2020 May 20.

Department of Periodontology and Oral Medicine, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, NO.195 Dongfeng West Road, Guangzhou, 510140, China.

Background: To evaluate whether oral lichen planus (OLP) is a risk factor for peri-implant diseases (PIDs) with a systematic review and meta-analysis.

Methods: Five electronic databases including Medline, Embase, Web of Science, the Cochrane Library and Scopus were searched. The included studies are observational human studies written in English. Read More

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http://dx.doi.org/10.1186/s12903-020-01134-2DOI Listing

Non-bullous Lichen Planus Pemphigoides: A Case Report.

Acta Derm Venereol 2020 May 19. Epub 2020 May 19.

Department of Dermatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9700 RB Groningen, The Netherlands. E-mail:

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http://dx.doi.org/10.2340/00015555-3523DOI Listing

Oral bacterial diversity is inversely correlated with mucosal inflammation.

Oral Dis 2020 May 17. Epub 2020 May 17.

Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, 53100, Italy.

Objective: We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP).

Methods: Patients with RAS (n=15), LP (n=18) and healthy controls (n=13) were recruited using criteria to reduce the effect of factors that influence the microbiota structure independently of oral mucosal disease. Clinical severity was quantified using validated scoring methods. Read More

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http://dx.doi.org/10.1111/odi.13420DOI Listing

Frontal Fibrosing Alopecia: A Retrospective Study of 75 Patients.

Actas Dermosifiliogr 2020 May 14. Epub 2020 May 14.

Servicio de Dermatología, Hospital Universitario Infanta Sofía, Madrid, Spain.

Background And Objective: Frontal fibrosing alopecia is an increasingly common form of scarring alopecia. The aim of this study was to describe the demographic and clinical characteristics of patients with FFA seen at the trichology unit of a medium-sized regional hospital and to report on treatments used.

Material And Methods: We reviewed the medical records of all patients with FFA seen at the trichology unit of Hospital Universitario Infanta Sofía in Madrid, Spain between May 2016 and May 2018. Read More

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http://dx.doi.org/10.1016/j.ad.2020.03.003DOI Listing

Dermoscopy in differential diagnosis of inflammatory dermatoses and mycosis fungoides.

Int J Dermatol 2020 May 13. Epub 2020 May 13.

Department of Dermatology, Firat University Hospital, Elazig, Turkey.

Background: The use of dermoscopy for the evaluation of various inflammatory dermatoses has witnessed a gradual increase in recent years. The present study describes and highlights the importance of dermoscopic findings in the differential diagnosis of plaque psoriasis (PP), lichen planus (LP), mycosis fungoides (MF), pityriasis rosea (PR), and nummular dermatitis (ND) that mostly involve the trunk.

Methods: The study included 150 cases (PP:50, LP:30, MF:20, PR:30, ND:20). Read More

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http://dx.doi.org/10.1111/ijd.14925DOI Listing

Comparison of therapeutic efficacy of topical treatment with phenytoin and fluocinolone on cutaneous lichen planus: A randomized, double-blind trial.

Dermatol Ther 2020 May 13:e13578. Epub 2020 May 13.

Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1111/dth.13578DOI Listing

Nothing to Sneeze at: Histamine and Histamine Receptors in Oral Carcinogenesis.

Oral Dis 2020 May 12. Epub 2020 May 12.

Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, 00014, Helsinki, Finland.

Oral squamous cell carcinoma (OSCC), the most common oral malignancy, shows an increasing rate of incidence worldwide. In spite of the recent advances in cancer research, OSCC therapy continues to have unfavourable outcomes, and thus patient's prognosis remains relatively poor. Current research has been devoted to identifying novel therapeutic targets also in the tumour microenvironment (TME). Read More

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http://dx.doi.org/10.1111/odi.13411DOI Listing

Induction of High Endothelial Venule-like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study.

J Histochem Cytochem 2020 May;68(5):343-350

Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui.

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease involving the oral mucosa and skin. Both oral LP (OLP) and cutaneous LP (CLP) are histopathologically characterized by dense subepithelial lymphocyte infiltrates; however, the mechanisms underlying lymphocyte recruitment to sites of LP lesions are not fully understood. Here, we assessed the induction of peripheral lymph node addressin (PNAd)-expressing high endothelial venule (HEV)-like vessels in 19 OLP and 17 CLP cases. Read More

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http://dx.doi.org/10.1369/0022155420923272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226624PMC

Recommendations for Treatment of Nail Lichen Planus During the COVID-19 Pandemic.

Dermatol Ther 2020 May 10:e13551. Epub 2020 May 10.

Department of Dermatology, Weill Cornell Medicine, NY, NY.

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http://dx.doi.org/10.1111/dth.13551DOI Listing

Clinicopathological and prognostic characterization of oral lichenoid disease and its main subtypes: A series of 384 cases.

Med Oral Patol Oral Cir Bucal 2020 May 10. Epub 2020 May 10.

Department of Stomatology II University of the Basque Country (UPV/EHU) Barrio Sarriena sn. 48940. Leioa, Spain

Background: To clinicopathologically characterize the diagnosis of oral lichenoid disease (OLD) and its main subtypes: oral lichen planus (OLP) and oral lichenoid lesion (OLL), in order to correctly asses their prognosis.

Material And Methods: Ambispective cohort study of 384 patients with diagnosis of OLD, based on pre-established clinical and histopathological criteria. We have analysed 272 (70. Read More

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http://dx.doi.org/10.4317/medoral.23576DOI Listing

A case of delayed allergic reaction caused by local injection of triamcinolone acetonide.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):216-220

Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology & Hunan Key Laboratory of Oral Health Research, Central South University, Changsha 410008, China

Glucocorticoid is a commonly used anti-inflammatory and anti-allergic drug in clinic. Allergic reactions caused by glucocorticoids are rare in clinic. Glucocorticoid allergy is a type of allergic reaction caused by glucocorticoid as an allergen, and its clinical manifestations of hypersensitivity are not specific. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180584DOI Listing
February 2020

Linear crusted papules in an infant.

JAAD Case Rep 2020 May 30;6(5):441-443. Epub 2020 Apr 30.

Apex Dermatology and Skin Surgery Center, Mayfield Heights, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200436PMC

Childhood erythrodermic lichen planus pemphigoides after nonavalent human papillomavirus vaccination.

JAAD Case Rep 2020 May 30;6(5):431-433. Epub 2020 Apr 30.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1016/j.jdcr.2020.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200189PMC

Evaluation and Expression of Survivin in Potentially Malignant Lesions and Squamous Cell Carcinoma: A Comparative Study.

Cureus 2020 Apr 5;12(4):e7551. Epub 2020 Apr 5.

Oral and Maxillofacial Surgery, Thai Moogambigai Dental College and Hospital, Chennai, IND.

Introduction Overexpression of survivin, an anti-apoptotic protein, has been associated with the progression of cancer, resistance to drugs, and a poor prognosis. The expression level of survivin indicates the progression of the disease, early recurrence, and a failure to respond to therapy. Our study was a retrospective analysis performed on archival specimens. Read More

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http://dx.doi.org/10.7759/cureus.7551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202583PMC

Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders.

Kurume Med J 2020 May 1. Epub 2020 May 1.

AL-FALAH School of Medical Sciences and Research Center, AL- Falah University.

Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (TXN2). They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. Read More

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http://dx.doi.org/10.2739/kurumemedj.MS661009DOI Listing

Dyslipidemia in Lichen Planus: A Case-control Study.

Sisli Etfal Hastan Tip Bul 2020 25;54(1):62-66. Epub 2020 Mar 25.

Department of Dermatology, Health Sciences University Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objective: Lichen planus (LP) is a chronic inflammatory disease that affects the skin, mucous membranes, scalp and nails. It has been reported that diabetes mellitus and dyslipidemia prevalence were higher in patients with LP. However, most of these reports were retrospective, database search, which included patients who were on lipid-lowering drugs. Read More

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http://dx.doi.org/10.14744/SEMB.2018.48108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192257PMC

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Ocul Surf 2020 May 3. Epub 2020 May 3.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.04.005DOI Listing

Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action.

J Ethnopharmacol 2020 May 1;258:112913. Epub 2020 May 1.

Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Characteristic Chinese Drug Resources in Southwest China, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Chengdu 611137, China. Electronic address:

Ethnopharmacological Relevance: Paeoniae Radix Alba (PRA, called baishao in China), the root of Paeonia lactiflora Pall., has shown a rich medicinal value for more than 2000 years. PRA is used in local medicine and traditional medicine for autoimmune diseases associated with inflammation. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112913DOI Listing
May 2020
2.998 Impact Factor

Meaningful improvement thresholds in measures of pain and quality of life in oral lichen planus.

Oral Dis 2020 May 4. Epub 2020 May 4.

UCL Eastman Dental Institute, London, United Kingdom.

Objectives: To evaluate the responsiveness of measures of pain and oral health-related quality of life (OH-QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population.

Methods: Data from baseline and 4-month follow-up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14-item Oral Health Impact Profile (OHIP-14), 15-item and 26-item Chronic Oral Mucosal Disease Questionnaire (COMDQ-15; COMDQ-26) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. Read More

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http://dx.doi.org/10.1111/odi.13379DOI Listing

Nails: The Window to the Nose? Update on Yellow Nail Syndrome.

Dermatol Pract Concept 2020 3;10(2):e2020031. Epub 2020 Apr 3.

Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

Background: Yellow nail syndrome is a rare condition characterized by typical nail alterations and variable presence of lymphedema and respiratory disease. The pathogenesis is still obscure, with most of the literature deriving from case reports and few investigations. The most reported respiratory conditions associated with yellow nail syndrome are pleural effusion and bronchiectasis, whereas association with rhinosinusitis is rarer. Read More

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http://dx.doi.org/10.5826/dpc.1002a31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190560PMC

Intraoperative Onychoscopy and Histopathological correlation of Red Lunula in Nail lichen planus: A case series.

Authors:
I Kaur D Jakhar

Clin Exp Dermatol 2020 May 1. Epub 2020 May 1.

Dermatology, Venereology and Leprosy, Hindu Rao Hospital, New Delhi, India.

The lunula is the white half-moon-shaped area located at the base of fingernails and toenails. It is the only visible part of nail matrix. Red lunula can present as a complete form (whole lunula is red), incomplete form (only proximal lunula is red) or as mottled form. Read More

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http://dx.doi.org/10.1111/ced.14265DOI Listing

The effect of smoking on clinical presentation and expression of TLR-2 and CD34 in Oral lichen Planus patients: clinical and immunohistochemical study.

BMC Oral Health 2020 Apr 29;20(1):129. Epub 2020 Apr 29.

Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Background: Oral lichen planus is a chronic inflammatory disease which is considered as a potential precancerous condition. Numerous studies have confirmed that inflammation is a strong risk factor for cancer development. Smoking is associated with potentially malignant disorders of the oral and oropharyngeal mucosa. Read More

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http://dx.doi.org/10.1186/s12903-020-01118-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191681PMC

Relationship between salivary vitamin D deficiency and oral lichen planus.

Photodermatol Photoimmunol Photomed 2020 Apr 26. Epub 2020 Apr 26.

Oral & Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.

25(OH)D (Vit D) promotes differentiation of epithelial cells also prevent inappropriate apoptosis, and upregulation of inflammatory cytokines in keratinocytes. Vit D has immunosuppressive and immunomodulatory effects, regulates the production of inflammatory cytokines and immunoglobulins from activated lymphocytes T and B and inhibits antigen presentation to lymphocytes T. Consequently, inhibits the development of autoimmune diseases . Read More

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http://dx.doi.org/10.1111/phpp.12567DOI Listing

Guitar Pick as a Nail Prosthesis for Progressive Nail Lichen Planus.

J Am Acad Dermatol 2020 Apr 23. Epub 2020 Apr 23.

Weill Cornell Medicine, Department of Dermatology, NY, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.083DOI Listing

Answer to Photo Quiz White striae and erosions of the oral mucosa, but it is not oral lichen planus.

Neth J Med 2020 Apr;78(3):147

Unit of Oral and Maxillofacial Surgery, Ca Foncello Hospital, Treviso, Italy.

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White striae and erosions of the oral mucosa, but it is not oral lichen planus.

Neth J Med 2020 Apr;78(3):146

Unit of Oral and Maxillofacial Surgery, Ca Foncello Hospital, Treviso, Italy.

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Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22.

Hum Exp Toxicol 2020 Apr 24:960327120918291. Epub 2020 Apr 24.

Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

Background: Quercetin exerts anti-inflammatory effects, but whether it can benefit patients with the chronic inflammatory disease of oral lichen planus (OLP), which is a common chronic mucocutaneous disorder with an immune-mediated pathogenesis, is unclear. The present research examined the impacts of quercetin in a cell-based OLP model in which human oral keratinocytes (HOKs) were treated with lipopolysaccharide (LPS).

Methods: Effects of quercetin on viability, proliferation, and apoptosis of HOKs were assessed using the Cell Counting Kit-8 assay, Western blotting, and flow cytometry, respectively. Read More

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http://dx.doi.org/10.1177/0960327120918291DOI Listing

Anogenital High-Grade Squamous Intraepithelial Lesion Comorbid With Vulvar Lichen Sclerosus and Lichen Planus.

J Low Genit Tract Dis 2020 Apr 21. Epub 2020 Apr 21.

Faculty of Health and Medicine, University of Newcastle, New South Wales, Australia.

Objective: The aim of the study was to describe the clinicopathologic features of vulvovaginal or anal high-grade squamous intraepithelial lesion (HSIL) comorbid with lichen sclerosus and/or lichen planus (LS/LP).

Methods: The local pathology database identified 37 consecutive cases from 2007 to 2019 of vulvar, vaginal, or anal HSIL among women who had a histopathologic diagnosis of vulvar LS/LP. Cases had p16 and p53 immunoperoxidase stains. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000540DOI Listing

Serological and psychological assessment of patients with oral lichen planus using serum cortisol levels and hads questionnaire-a case control study.

J Popul Ther Clin Pharmacol 2020 Apr 6;27(2):e23-e31. Epub 2020 Apr 6.

Department of Oral Medicine and radiology, Panineeya institute of dental sciences, Hyderabad.

Background: Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disorder directed against antigens secreted by the basal cell layer, with an incidence of 0.02-0.22% in Indian population and showing female predilection. Read More

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http://dx.doi.org/10.15586/jptcp.v27i2.667DOI Listing

Prevalence of oral premalignant lesions and conditions among the population of Kanpur City, India: A cross-sectional study.

J Family Med Prim Care 2020 Feb 28;9(2):1080-1085. Epub 2020 Feb 28.

Department of Public Health Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India.

Background: The habit of smoking and chewing tobacco is associated with various types of oral mucosal lesions and conditions, many of which pose a potential threat to cancer growth. The present study aims to evaluate the prevalence of potentially malignant lesions (PML) and oral cancer in North India and to identify the associated risk factors.

Materials And Methods: A cross-sectional study was carried out in the Department of Oral Medicine and Radiology Rama Dental College Hospital and research center Kanpur over a period of 5 years with1,10,625 patients. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_912_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114062PMC
February 2020

A Case of Kikuchi-Fujimoto Disease Associated with Erosive Lichen Planus.

Cureus 2020 Mar 18;12(3):e7312. Epub 2020 Mar 18.

Department of Dermatology, College of Medicine, King Saud University, Riyadh, SAU.

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disorder with unknown etiology. The most frequent clinical manifestations include lymphadenopathy, fever, cutaneous lesions, arthritis, fatigue, and hepatosplenomegaly. Cutaneous manifestations of KFD, occurring in about one-third of patients, are typically non-specific, rarely presenting as symmetrically distributed lesions. Read More

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http://dx.doi.org/10.7759/cureus.7312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164705PMC

Report of two cases of mucous membrane pemphigoid with frontal fibrosing alopecia: A variant of lichen planus pemphigoides or an incidental finding?

Clin Exp Dermatol 2020 Apr 20. Epub 2020 Apr 20.

Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.

Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by the coexistence of both lichen planus and bullous pemphigoid or mucous membrane pemphigoid (MMP) features. Frontal fibrosing alopecia (FFA) is a scarring alopecia, generally considered as a form of lichen planopilaris. Case 1 was a 70-year-old woman with clinical and histological diagnosis of oral lichen planus. Read More

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http://dx.doi.org/10.1111/ced.14248DOI Listing

Lichenoid Keratosis: A Clinical Trap without Secrets for Reflectance Confocal Microscopy.

Case Rep Dermatol 2020 Jan-Apr;12(1):47-51. Epub 2020 Mar 20.

Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.

Lichenoid keratosis, also defined as benign lichenoid keratosis, was reclassified as lichen planus-like keratosis by Shapiro and Ackerman. Clinical and dermoscopic features of lichen planus-like keratosis can vary, often not providing useful and necessary information to perform an accurate diagnosis without performing a biopsy or histological examination. We describe 2 difficult to detect lichen planus-like keratosis cases in which we performed reflectance confocal microscopy. Read More

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http://dx.doi.org/10.1159/000506669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154274PMC

No evidence for association between cutaneous lichen planus and hepatitis B and C virus infection in south Poland - a case-control study.

Int J Dermatol 2020 Jun 19;59(6):698-703. Epub 2020 Apr 19.

Department of Dermatology, University of Rzeszów, Rzeszów, Poland.

Background: The incidence of hepatitis C virus (HCV) infection among patients with lichen planus (LP) varies considerably. Currently, there is more evidence for the association between hepatitic C and oral LP (OLP) than cutaneous LP (CLP). There is also lack of data on the Polish population. Read More

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http://dx.doi.org/10.1111/ijd.14880DOI Listing

Clinicopathological and prognostic characteristics of oral squamous cell carcinomas arising in patients with oral lichen planus: A systematic review and a comprehensive meta-analysis.

Oral Oncol 2020 Apr 16;106:104688. Epub 2020 Apr 16.

School of Dentistry, University of Granada, Granada, Spain. Electronic address:

Objectives: To evaluate current evidence in relation to the prognostic and clinicopathological significance of oral squamous cell carcinomas arising in patients with oral lichen planus (OLP-OSCC).

Material And Methods: We searched PubMed, Embase, Web of Science and Scopus for studies published before May-2019. We evaluated the quality of studies (QUIPS tool). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104688DOI Listing

A probable surge in oral lichen planus cases under the aura of coronavirus in females in India.

Oral Oncol 2020 Apr 15:104714. Epub 2020 Apr 15.

All India Institute of Medical Sciences, Bhubaneswar, India.

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http://dx.doi.org/10.1016/j.oraloncology.2020.104714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158810PMC

Lichenoid folliculitis in facial lichen planus pigmentosus - a clue to frontal fibrosing alopecia?

J Cutan Pathol 2020 Apr 17. Epub 2020 Apr 17.

Department of Dermatology, Boston University School of Medicine, Boston, USA.

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http://dx.doi.org/10.1111/cup.13715DOI Listing

Aquaporin3 (AQP3) expression in oral epithelium in oral lichen planus.

Exp Mol Pathol 2020 Apr 11;115:104441. Epub 2020 Apr 11.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Iran; Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Lichen Planus is an autoimmune disease of skin and mucous membranes, including oral mucosa and genital organs, with the potential to undergo a malignant transformation. Xerostomia and the salivary gland hypofunction are common manifestations and complications in oral lichen planus (OLP), whose exact cause has not been well defined yet. Aquaporins (AQP) are a family of membrane channel cell proteins which play an important role in the intercellular water permeability. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104441DOI Listing

Epigenetic factors involved in the pathophysiology of inflammatory skin diseases.

J Allergy Clin Immunol 2020 Apr;145(4):1049-1060

Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address:

Epigenetics has been discussed as a potential factor influencing the pathophysiology and severity of inflammatory skin diseases. In recent years, emerging evidence suggests that epigenetic mechanisms are involved in the pathophysiology of not only atopic dermatitis (AD) and psoriasis (PSO) but also lupus erythematosus and oral lichen. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of methylation patterns in inflammatory skin disease. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.10.015DOI Listing

Pigmented linear discoid lupus erythematosus following the lines of Blaschko: A retrospective study of a Chinese series.

Indian J Dermatol Venereol Leprol 2020 Apr 7. Epub 2020 Apr 7.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Skin and Immune Diseases, Beijing, China.

Background: Linear cutaneous lupus erythematosus is a rare subtype of lupus erythematosus (LE) that develops linear lesions following the lines of Blaschko. Linear cutaneous lupus erythematosus may present as various subtypes of LE, including linear discoid lupus erythematosus. There are few reports about pigmentedlinear discoid lupus erythematosus in the literature. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_341_19DOI Listing

Perianal Disease and Granulomas: Think Out of the Box….

GE Port J Gastroenterol 2020 Feb 1;27(2):119-123. Epub 2019 Oct 1.

Pediatric Gastroenterology Unit, Centro Hospitalar Universitário do São João, Porto, Portugal.

Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency due to a malfunction of NADPH oxidase. It is characterized by recurrent and severe infections caused by catalase-positive microorganisms and autoinflammatory manifestations. Recently, there has been described an gene variant that causes a deficiency of p40, a subunit of NADPH oxidase. Read More

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http://dx.doi.org/10.1159/000502358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113594PMC
February 2020

Evaluation of PD-L1, PD-L2, PD-1 and cytotoxic immune response in oral lichen planus.

Oral Dis 2020 Apr 7. Epub 2020 Apr 7.

Department of Stomatology (Oral Medicine and Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, Brazil.

Objective: To investigate the expression of programmed death-ligands 1 and 2 (PD-L1, PD-L2), programmed death-1 (PD-1), CD8 and granzyme B (GrB), as well as its correlation with the severity of oral lichen planus (OLP).

Materials And Methods: In a collaborative study, 33 cases of OLP were evaluated according to the latest criteria proposed by the American Academy of Oral and Maxillofacial Pathology (AAOMP/2016) and were submitted to immunohistochemistry. Positivity was measured semiquantitatively (PD-L1, PD-L2) and quantitatively (PD-1, CD8, GrB). Read More

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http://dx.doi.org/10.1111/odi.13344DOI Listing

Atorvastatin-induced Lichenoid Drug Eruption: A Case Report and Review of Statin-associated Cutaneous Adverse Events.

Cureus 2020 Mar 1;12(3):e7155. Epub 2020 Mar 1.

Dermatology, San Diego Family Dermatology, National City, USA.

Statin medications [3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors] are generally used to treat hypercholesterolemia. Lichenoid drug eruptions are a potential cutaneous side effect of medications including antibiotics, antimalarials, and statins. This drug eruption can mimic features of idiopathic lichen planus in clinical presentation and pathology. Read More

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http://dx.doi.org/10.7759/cureus.7155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108677PMC

Expression of nucleotide-binding oligomerization domain 1 and 2 in oral lichen planus.

J Dent Sci 2020 Mar 18;15(1):1-8. Epub 2020 Jan 18.

Department of Oral and Maxillofacial Pathology, College of Dentistry, Wonkwang Bone Regeneration Research Institute, Daejeon Dental Hospital, Wonkwang University, Daejeon, Republic of Korea.

Background/purpose: Oral lichen planus (OLP) is a chronic inflammatory disease of oral mucosa. The present study investigated the expression of nucleotide-binding oligomerization domain (NOD), a pivotal sensor protein of the innate immune system, in OLP.

Materials And Methods: Oral mucosal biopsies were collected from 20 patients with OLP and 6 individuals with normal oral mucosa (NOM). Read More

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http://dx.doi.org/10.1016/j.jds.2019.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109494PMC
March 2020
0.465 Impact Factor

Exploring the EQ-5D Dimension of Pain/Discomfort in Dermatology Outpatients from a Multicentre Study in 13 European Countries.

Acta Derm Venereol 2020 Apr 21;100(8):adv00120. Epub 2020 Apr 21.

Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS FLMM, Via dei Monti di Creta 104, IT-00167 Rome, Italy.

Pain and discomfort are important symptoms in dermatology. The aim of this cross-sectional, multicentre study was to describe the prevalence of pain/discomfort and its associations in patients with several dermatological conditions across 13 European countries. The outcome was the prevalence of pain/discomfort according to a question of the EQ-5D questionnaire. Read More

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http://dx.doi.org/10.2340/00015555-3477DOI Listing

Possible role of vitamin d in pathogenesis of lichenoid dermatoses (a review of literature).

Wiad Lek 2020 ;73(2):365-369

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: The aim of the study was search and analysis of the data of review, experimental and clinical scientific and medical publications on the issues of the possible role of VD inpathogenesis of lichenoid dermatoses.

Patients And Methods: Materials and methods: An analysis of the studying of the scientific and medical literature was shown. Searching was carried out through the PubMed/MEDLINE portal from the databases of the National Center Biotechnology Information, Web of Science Core Collection, U. Read More

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Does autoimmune thyroid disorder act as a predisposing factor in the development of oral lichen planus?

Oral Dis 2020 Apr 4. Epub 2020 Apr 4.

Oral Medicine Division, Department of Stomatology, School of Dentistry, University of São Paulo, Brazil.

Considering previous data from our clinic, as had consistently demonstrated a significant number of OLP patients also reporting thyroid disease (Hashimoto's thyroiditis, in particular), the present study investigated the prevalence of OLP in patients with autoimmune thyroid disease, including Hashimoto's thyroiditis and Graves' disease. Read More

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http://dx.doi.org/10.1111/odi.13339DOI Listing

Dysbiosis of saliva microbiome in patients with oral lichen planus.

BMC Microbiol 2020 Apr 3;20(1):75. Epub 2020 Apr 3.

Department of Periodontology, Shanxi Medical University School and Hospital of Stomatology, No. 63, New South Road, Yingze District, Taiyuan, Shanxi, 030001, People's Republic of China.

Background: Oral microbiota is not only important for maintaining oral health but also plays a role in various oral diseases. However, studies regarding microbiome changes in oral lichen planus (OLP) are very limited. To the best of our knowledge, there has been only two studies investigating salivary microbiome changes in OLP. Read More

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http://dx.doi.org/10.1186/s12866-020-01733-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118920PMC
April 2020
2.729 Impact Factor