Search our Database of Scientific Publications and Authors

I’m looking for a

    8671 results match your criteria Lichen Planus

    1 OF 174

    Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child.
    Pediatr Dermatol 2017 May 23. Epub 2017 May 23.
    Division of Dermatology, Department of Pediatrics, School of Medicine, Seattle Children's Hospital, University of Washington, Seattle, Washington.
    We present the case of a 12-year-old-girl who developed lichenoid dermatitis approximately 1 year after starting leflunomide for juvenile idiopathic arthritis. The eruption resolved promptly with discontinuation of the suspected culprit agent, supportive of a lichenoid drug eruption, but she subsequently developed markedly dystrophic nails with lichen planus-like features. A biopsy of her cutaneous findings at the time of initial presentation demonstrated lichenoid dermatitis, and a nail matrix biopsy was deferred given clinical correlation. Read More

    Oral lichenoid lesions of the upper lip.
    J Dermatol Case Rep 2017 Mar 31;11(1):16-19. Epub 2017 Mar 31.
    Dental Clinic, Penteli Children's General Hospital, Athens, Greece.
    Background: Oral lichen planus is a chronic inflammatory disease of unknown etiology. It is characterized by notable heterogeneity in clinical presentation and behavior.

    Main Observations: We describe 3 patients with lichenoid lesions of the upper lip and upper anterior gingiva. Read More

    Bullous lichen planus - a review.
    J Dermatol Case Rep 2017 Mar 31;11(1):1-4. Epub 2017 Mar 31.
    Department of Dermatology, Army General Hospital, Athens, Greece.
    Bullous lichen planus is a rare variant of lichen planus. It is characterized by vesicles or bullae, which usually develop in the context of pre-existing LP lesions. It is often misdiagnosed and should be differentiated from other subepidermal bullous diseases especially lichen planus pemphigoides. Read More

    Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus.
    An Bras Dermatol 2017 Mar-Apr;92(2):168-171
    Dental Research Center, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences - Tehran, Iran.
    Background:: Oral lichen planus is a potentially malignant disorder. One of the malignant transformation markers is cancer stem cells. One of the proposed marker for the detection of cancer stem cells's in head and neck cancer is aldehyde dehydrogenase. Read More

    Diagnosis, Treatment, and Surgical Repair in a Case of Isolated Conjunctival Lichen Planus Causing Cicatricial Entropion.
    Ophthal Plast Reconstr Surg 2017 May 22. Epub 2017 May 22.
    *Division of Ophthalmology, Warren Alpert Medical School at Brown University, Providence, Rhode Island, and †Department of Ophthalmology, State University of New York Upstate Medical University, Syracuse, New York, U.S.A.
    A 50-year-old male presented with bilateral cicatricial entropion with subepithelial fibrosis and fornix foreshortening. Conjunctival biopsy showed lymphocytic infiltrate along the interface of the epithelium and lamina propria with linear, shaggy fibrinogen deposition along the epithelial basement membrane zone, supporting a diagnosis of lichen planus. The patient was treated with commercially available topical cyclosporine for 5 months after which bilateral lower eyelid splitting procedure with recession of the anterior lamella and complete excision of the lower eyelid lashes was performed. Read More

    Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review.
    Lasers Med Sci 2017 May 24. Epub 2017 May 24.
    Department of Oral Medicine and Diagnostic Sciences, Al-Farabi Colleges, Riyadh, Saudi Arabia.
    Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology and indefinite cure. This systematic review assessed the efficacy of low-level laser therapy in the treatment of symptomatic OLP. Electronic databases (PubMed, Scopus, and Web of Science) were searched from date of inception till and including December 2016, using various combinations of the following keywords: oral lichen planus, laser therapy, low-level laser therapy, and phototherapy. Read More

    Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.
    Pan Afr Med J 2017 3;26:125. Epub 2017 Mar 3.
    The Ronald Perelman Department of Dermatology, New York University School of Medicine, USA.
    Introduction: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Read More

    Identifying the association between interleukin-6 and lichen planus: A meta-analysis.
    Biomed Rep 2017 May 7;6(5):571-575. Epub 2017 Apr 7.
    Department of Pediatric Dentistry, Jinan Stomatological Hospital, Jinan, Shandong 250002, P.R. China.
    Numerous studies have examined the association between interleukin-6 and the pathogenesis of lichen planus (LP)/oral LP (OLP) in various populations; however, there is a lack of systematic analysis. The aim of the present study was to assess this association more precisely, thus a meta-analysis was performed. Case-control studies, which were published up to December 2015, were obtained from PubMed, Embase and the China National Knowledge Infrastructure databases. Read More

    Quantification of l-carvone in toothpastes available on the Swedish market.
    Contact Dermatitis 2017 May 19. Epub 2017 May 19.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. Read More

    MicroRNA in skin diseases.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Department of Pathophysiology, Krasnoyarsk State Medical University, P. Zeleznyaka str. 1, 660022, Krasnoyarsk, Russian Federation.
    MicroRNAs are essential regulators of various cellular processes such as cell growth, differentiation, apoptosis, and the immune response, acting as factors for translational repression and/or degradation of target messenger RNA. Currently, microRNAs are considered as promising biomarkers and therapeutic targets for different pathological conditions. Skin may serve as a convenient model for microRNA modulation studies due to the comparatively easy access to targets cells. Read More

    A panel of microRNAs can be used to determine oral squamous cell carcinoma.
    J Oral Pathol Med 2017 May 17. Epub 2017 May 17.
    Melbourne Dental School, The University of Melbourne, Melbourne, VIC, 3053, Australia.
    Background: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances of a panel of microRNA could be an objective OSCC indicator.

    Method: Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. Read More

    Skin diseases and tattoos: a five-year experience.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, University of Naples Federico II, Naples, Italy -
    Background: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Read More

    The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus.
    J Dermatol Sci 2017 May 1. Epub 2017 May 1.
    Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address:
    Background: CARD18 contains a caspase recruitment domain (CARD) via which it binds to caspase-1 and thereby inhibits caspase-1-mediated activation of the pro-inflammatory cytokine interleukin (IL)-1β.

    Objectives: To determine the expression profile and the role of CARD18 during differentiation of keratinocytes and to compare the expression of CARD18 in normal skin and in inflammatory skin diseases.

    Methods: Human keratinocytes were induced to differentiate in monolayer and in 3D skin equivalent cultures. Read More

    Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression.
    Inflammopharmacology 2017 May 13. Epub 2017 May 13.
    Hematology and Blood Banking Department, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. Read More

    Probiotics: A non-conventional therapy for oral lichen planus.
    Arch Oral Biol 2017 Apr 26;81:90-96. Epub 2017 Apr 26.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, PR China. Electronic address:
    Oral lichen planus (OLP) is a common T-cell mediated chronic inflammatory disease. Although the etiology is still unclear, present studies suggest that the composition of the oral microbiota and psychological problems are implicated in the etiology of OLP. The pathogenesis of OLP includes mainly antigen-specific and non-specific mechanisms. Read More

    Tumor-like microenvironment in oral lichen planus: evidence of malignant transformation?
    Expert Rev Clin Immunol 2017 Jun 28;13(6):635-643. Epub 2017 Feb 28.
    a The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology , Wuhan University , Wuhan , P.R. China.
    Introduction: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory autoimmune disease affecting 0.1% to 4% of the world population. The WHO has already recognized it as an oral potentially malignant disorder. Read More

    Lichenoid vulvar disease: A review.
    Int J Womens Dermatol 2017 Mar 27;3(1):58-64. Epub 2017 Mar 27.
    The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, NY.
    Vulvar dermatoses are common, potentially debilitating conditions that can be seen by a variety of medical specialists. Lichenoid vulvar diseases, namely lichen sclerosus (LS), lichen planus (LP), and lichen simplex chronicus (LSC), can all negatively impact patients' quality of life and LS and LP also have an association with squamous cell carcinoma. It is essential that dermatologists are familiar with the unique features of each of these conditions to ensure the appropriate management and follow up. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    Activated Akt/mTOR-autophagy in local T cells of oral lichen planus.
    Int Immunopharmacol 2017 May 5;48:84-90. Epub 2017 May 5.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China. Electronic address:
    Oral lichen planus (OLP) is a chronic inflammatory disease regulated by T cell-mediated immune response. Autophagy and its major inhibitory pathway Akt/mTOR participate in T cell metabolism and homeostasis, which has been implicated in autoimmune diseases. In this study, the potential involvement of autophagy and its regulatory Akt/mTOR pathway were investigated in local T cells of OLP. Read More

    Examination of circulating serum autoantibodies and hematinics is important for treatment of oral lichen planus.
    J Formos Med Assoc 2017 May 4. Epub 2017 May 4.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

    Annular Lichenoid Dermatitis (of Youth): Report of a Case With Lichen Planus-Like Features.
    Am J Dermatopathol 2017 Apr 25. Epub 2017 Apr 25.
    Department of Anatomic Pathology, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
    Annular lichenoid dermatitis of youth (ALDY), a dermatosis with peculiar clinical and pathological features, represents still a debated entity, given its similarity, among others, with mycosis fungoides. A case of ALDY in a 50-year-old male patient is reported. Clinically, the patient presented an oval scleroderma-like plaque on the right flank. Read More

    Nodular Sclerodermatous Chronic Cutaneous Graft-Versus-Host Disease (GvHD): A New Clinicopathological Variant of Cutaneous Sclerodermatous GvHD Resembling Nodular/Keloidal Scleroderma.
    Am J Dermatopathol 2017 Apr 25. Epub 2017 Apr 25.
    *Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain;†Dermatopathology Research Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; and‡School of Pathology, University of Milan, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
    Cutaneous chronic graft-versus-host disease (GvHD) has a broad spectrum of clinicopathological presentations, the most common ones being poikiloderma, lichen planus-like eruptions, lichen sclerosus-like lesions, morphea-like plaques, and deep sclerosis. New forms of chronic cutaneous GvHD with different clinicopathological characteristics have been described, most of them mimicking cutaneous manifestations of autoimmune diseases. We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract. Read More

    Exacerbations of oral lichen planus and elevated levels of aminotransferases.
    Int J Dermatol 2017 May 5. Epub 2017 May 5.
    Maxillo-Facial and Odontostomatology Unit (Head: prof. AB. Giannì) Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
    Background: Liver enzymes appear to be involved in oral lichen planus (OLP), but it is not known whether the elevation develops concomitantly with exacerbations of disease. We compared the levels of serum hepatic aspartate (AST) and alanine (ALT) aminotransferases as markers of OLP exacerbation in patients with chronic hepatitis C from those with chronic liver disorders, seronegative for hepatitis C virus (HCV).

    Methods: We studied 71 patients with OLP, (48 HCV seropositive and 23 HCV seronegative with chronic liver diseases) measuring AST and ALT. Read More

    Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus.
    J Oral Pathol Med 2017 Apr 30. Epub 2017 Apr 30.
    Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: There is a reported relation between hyperhomocysteinemia and lichen planus (LP). An increase in homocysteine (Hcy) and the risk of cardiovascular disease (CVD) in patients with methylenetetrahydrofolate reductase (MTHFR) mutation has been described.

    Objective: To detect MTHFR (C677T) gene polymorphism, and to find its association with CVD risk, Hcy and folic acid levels in patients with LP. Read More

    [Uncommon dermatologic disorders triggered by radiation therapy of breast cancer: A case-series].
    Cancer Radiother 2017 Apr 28. Epub 2017 Apr 28.
    Institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Oncodermatologie, institut Claudius-Regaud, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France. Electronic address:
    Radiotherapy's main skin toxicities are now well-separated, acute (acute radiation dermatitis) or chronic complications (chronic radiation dermatitis, induced cutaneous carcinoma, aesthetic sequelae). Exceptionally, radiotherapy may induce, by isomorphic reaction or Koebner's phenomenon, some specific dermatosis. In this article, we report five new observations of these unusual complications of radiation therapy, occurring in very variable time after breast irradiation and remaining strictly localized in the irradiated field (cutaneous mastocytosis, Sweet syndrome, lichen planus, vitiligo). Read More

    Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.
    Tumour Biol 2017 May;39(5):1010428317699113
    2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
    The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. Read More

    Evaluation Of Photodynamic Therapy In Treatment Of Oral Erosive Lichen Planus In Comparison With Topically Applied Corticosteroids.
    Photodiagnosis Photodyn Ther 2017 Apr 24. Epub 2017 Apr 24.
    Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt.
    Background: The treatment of erosive oral lichen planus represents a therapeutic challenge. Despite numerous existing remedies, some of these treatments display disappointed results. Since it is a chronic disease with no current cure, the best treatment should target mainly the reduction of the duration and severity of symptomatic outbreaks with minimal side effects. Read More

    Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: a case report.
    Clin J Gastroenterol 2017 Jun 26;10(3):270-273. Epub 2017 Apr 26.
    Division of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan.
    Hepatitis C virus (HCV) infection remains the main cause of liver disease and can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV may also develop extrahepatic manifestations in the skin, eyes, joints, kidneys, nervous system, and immune system. In fact, several studies reported that up to 70% of HCV patients experienced extrahepatic manifestations. Read More

    Comparative Analysis of Immunopathological Features of Lichen Planopilaris and Female Patients with Frontal Fibrosing Alopecia.
    Int J Trichology 2016 Oct-Dec;8(4):197-202
    Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Frontal fibrosing alopecia (FFA) is a disorder characterized by progressive cicatricial alopecia (CA). Its classification as a clinical variant of lichen planopilaris (LPP) or as a unique disorder is controversial. The presence of Langerhans cells within the bulge area and the sebaceous epithelium and the presence of lymphocytic infiltrate in this area in CA have led to a series of hypotheses, although limited, about their development. Read More

    Graham-Little-Piccardi Syndrome: A Lens Through beyond What is Known.
    Int J Trichology 2016 Oct-Dec;8(4):173-175
    Postgraduate Institute of Medical Education and Research, Kolkata, West Bengal, India.
    Graham-Little-Piccardi syndrome (GLPS) is a rare form of follicular lichen planus and comprises cicatricial alopecia of the scalp, noncicatricial alopecia of the axillae, and/or pubis and spinous follicular papules involving the trunk and extremities. We herein report a classic case of GLPS in a 49-year-old female. Uniqueness of our case is due to its additional features of frontal fibrosing alopecia (FFA). Read More

    Vulvo-vaginal ano-gingival syndrome: Another variant of mucosal lichen planus.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):86-88
    Department of Dermatology, Government Medical College, Amritsar, Punjab, India.
    Vulvo-vagino-gingival syndrome was described as a distinctive pattern of erosive plurimucosal lichen planus (LP), and it is a clinical triad of vulval, vaginal, and gingival LP. It can lead to sequelae such as vaginal and urethral stenosis which can have severe implications on the quality of life. We report a case of a 40-year-old female who developed urethral, vaginal, as well as anal stenosis as a result of long-term exclusive mucosal LP involving vulvo-vaginal and anal mucosa along with oral LP without any other cutaneous involvement. Read More

    Study of pruritus vulvae in geriatric age group in tertiary hospital.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):15-21
    Department of Dermatology, Venereology, Leprosy, Government Medical College, Amritsar, Punjab, India.
    Background: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. Read More

    Cutaneous Complications Related to Tattoos: 31 Cases from Finland.
    Dermatology 2017 Apr 26. Epub 2017 Apr 26.
    Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Background: Cutaneous complications related to permanent tattoos affect 2-30% of those patients who have tattooed their skin. Little is known about the cases of tattoo complications in Finland.

    Objective: The aim of this study was to conduct a retrospective review of a series of Finnish patients with cutaneous tattoo reactions. Read More

    Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data.
    Oral Oncol 2017 May 5;68:92-102. Epub 2017 Apr 5.
    Faculty of Oral and Dental Medicine, Beni Suef University, Beni Suef, Egypt.
    Objectives: For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into oral squamous cell carcinoma (OSCC).

    Materials And Methods: We searched Medline, Scopus, and Web of Knowledge for relevant observational studies. Read More

    Successful treatment of bullous lichen planus with acitretin monotherapy. Review of treatment options for bullous lichen planus and case report.
    J Dermatol Case Rep 2016 Dec 31;10(4):62-64. Epub 2016 Dec 31.
    2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, "Attikon" General University Hospital, Athens, Greece.
    Background: Bullous lichen planus (BLP) is a rare variant of lichen planus, characterized by the development of vesicular and bullous lesions, of skin, nails, hair and/or mucosa.

    Main Observations: We present a case of 63-year-old woman with BLP, unresponsive to previous therapies with topical corticosteroids, topical calcipotriol, antihistamines and oral cyclosporine (4 mg/kg/day for 4 months). She was already receiving treatment for arterial hypertension, hyperlipidemia, atrial fibrillation and uncontrolled diabetes mellitus. Read More

    Oral lichen planus: a 4-year clinical follow-up study.
    Turk J Med Sci 2017 Apr 18;47(2):514-522. Epub 2017 Apr 18.
    Institute of Odontology, Faculty of Medicine, University of Vilnius, Vilnius, Lithuania.
    Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors.

    Materials And Methods: All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Read More

    Ascorbic acid deficiency in patients with lichen planus.
    J Immunoassay Immunochem 2017 Apr 19:1-8. Epub 2017 Apr 19.
    c Department of Dermatology , Carol Davila University of Medicine and Pharmacy , Bucharest , Romania.
    Objectives: Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study, the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin.

    Material And Method: We analyzed the level of urinary ascorbic acid (reflectometric method) in 77 patients with LP (cutaneous LP (CLP)-49 cases; oral LP (OLP)-28 cases) and 50 control subjects. Read More

    Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus.
    Arch Oral Biol 2017 Apr 7;80:110-116. Epub 2017 Apr 7.
    Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China.
    Objective: Oral lichen planus (OLP) presents with large numbers of T lymphocytes accumulating beneath the epithelium of the oral mucosa; however, its aetiology remains obscure. A potential role for an emerging novel T cell subset, Th9, in OLP has recently been suggested but remains to be clarified. The current aim was to investigate the expression and potential clinical significance of Th9 cells in distinct subtypes of OLP. Read More

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

    Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas.
    Oncoimmunology 2017 10;6(3):e1273310. Epub 2017 Feb 10.
    Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital , Helsinki, Finland.
    Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (CTCL), and evaluated the kynurenine (KYN) pathway in the local TME and in patient sera. Specimens from the total of 90 CTCL patients, including mycosis fungoides (MF, n = 37), lymphomatoid papulosis (LyP, n = 36), primary cutaneous anaplastic large cell lymphoma (pcALCL, n = 4), subcutaneous panniculitis-like T-cell lymphoma (SPTCL n = 13), and 10 patients with inflammatory lichen ruber planus (LRP), were analyzed by immunohistochemistry (IHC), immunofluorescence (IF), quantitative PCR, and/or liquid chromatography-tandem mass spectrometry (LC-MS/MS). Read More

    Treatment of recalcitrant erosive oral lichen planus and desquamative gingivitis with oral apremilast.
    J Dermatol Case Rep 2016 Nov 30;10(3):56-57. Epub 2016 Nov 30.
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center and University of Toronto, Toronto, Canada.
    Background: Erosive oral lichen planus and desquamative gingivitis are uncommon but severe debilitating variants of oral lichen planus. Treatment of these presentations is difficult and challenging.

    Main Observation: A 44-year-old woman was referred to the dermatology clinic with chronic painful lichen planus-related gingivitis and buccal erosions. Read More

    Detection of AMA-M2 in human saliva: Potentials in diagnosis and monitoring of primary biliary cholangitis.
    Sci Rep 2017 Apr 11;7(1):796. Epub 2017 Apr 11.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China.
    Serum anti-mitochondrial antibody type 2 (AMA-M2) is considered as a pivotal biomarker for the diagnosis of primary biliary cholangitis (PBC). However, serological tests have many limitations, including inconvenience, invasiveness, and infection risks. Thus, a less invasive approach to detect AMA-M2 titer is desirable. Read More

    [Oesophageal stricture caused by lichen planus and intramural pseudo-diverticulosis].
    Ugeskr Laeger 2017 Feb;179(6)
    We present the rare case of a proximal oesophageal stricture caused by a combination of oesophageal lichen planus without any other manifestations and intramural pseudo-diverticulosis, resulting in significant dysphagia. The diagnosis was not reached until a second set of biopsies were performed after split-dose treatment with proton pump inhibitors. Although local corticosteroid treatment was unsuccessful and symptomatic relief was only achieved after endoscopic dilatation, this case emphasizes the importance of adequate biopsies in the diagnosis of oesophageal strictures. Read More

    Lichenoid and interface dermatoses.
    Semin Diagn Pathol 2017 May 22;34(3):237-249. Epub 2017 Mar 22.
    Department of Radiation Oncology, The Ohio State University, Columbus, OH, United States.
    The terms 'lichenoid' and 'interface' dermatitis are often used interchangeably to describe an inflammatory pattern characterized histologically by damage to the basal keratinocytes in the epidermis. The mechanism of cell damage of such cells is now best understood as apoptosis, or programmed cell death. This inflammatory pattern of dermatoses, is also accompanied frequently by a band of lymphocytes and histiocytes in the superficial dermis, that often obscures the dermal-epidermal junction, hence the term 'lichenoid'. Read More

    1 OF 174