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    8793 results match your criteria Lichen Planus

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    Validation of immunoexpression of tenascin-C in oral precancerous and cancerous tissues using ImageJ analysis with novel immunohistochemistry profiler plugin: An immunohistochemical quantitative analysis.
    J Oral Maxillofac Pathol 2017 May-Aug;21(2):211-217
    Department of Oral Pathology and Microbiology, KLE University, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
    Background: Immunohistochemistry (IHC) is a molecular technique that has grown tremendously over the years. However, the assessment is only qualitative which is subjective and causes errors. Due to this limitation, several excellent markers have not gained importance and reached clinical trials. Read More

    Linear Lichen Planus: Continuum From Skin to Mucosa.
    J Cutan Med Surg 2017 Sep 1:1203475417733463. Epub 2017 Sep 1.
    1 Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India.
    Lichen planus (LP) is a chronic inflammatory disorder that most commonly affects middle-aged individuals. LP involves the skin and/or mucous membranes, including oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. Linear LP, a rare distinct variant of LP, is characterised by pruritic eruption of lichenoid and violaceous papules in a linear distribution. Read More

    Drug-induced oral lichenoid reactions: a real clinical entity? A systematic review.
    Eur J Clin Pharmacol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Libraries, New Orleans School of Dentistry, Louisiana State University Health Sciences Center, 1100 Florida Ave, New Orleans, LA, 70119, USA.
    Purpose: Drug-induced oral lichenoid reactions (DIOLRs) have been extensively reported in the literature, but the validity of the causality relationship between any drug and the oral lichenoid lesions (OLLs) still remains questionable. We sought to determine whether this causality relationship really exists, whether a resolution of the oral lesions upon withdrawal occurs, and what the most common alleged offending medications are.

    Methods: Nine electronic databases from January 1966 to December 2016 were systematically searched to identify all relevant studies selected with specific inclusion criteria (a clinical and histopathological diagnosis of DIOLRs, and clearly statement on the systemic offending medication). Read More

    Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus.
    J Oral Sci 2017 ;59(3):373-382
    Eastman Dental Institute, University College London.
    Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing body of evidence regarding the involvement of epithelial-derived cytokines, immune receptors, and costimulatory molecules in the pathobiological processes that promote and sustain OLP. Read More

    Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.
    J Periodontal Res 2017 Sep 12. Epub 2017 Sep 12.
    Department of Periodontology and Synoptic Dentistry, Charité - Medical University Berlin, Berlin, Germany.
    Background And Objectives: In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approach. However, their efficacy is limited. Read More

    Concepts and controversies in the treatment of cutaneous lichen planus: a review.
    G Ital Dermatol Venereol 2017 Sep 12. Epub 2017 Sep 12.
    Duke University Medical Center, Department of Dermatology and Durham VA Medical Center, Durham, NC, USA -
    Cutaneous lichen planus (CLP) is a chronic autoimmune disease classically associated with severely pruritic, polygonal, violaceous, flat-topped papules and plaques. Subtypes such as hypertrophic and bullous lichen planus and lichen planus pigmentosus have been described. Treatment can be challenging, and prospective controlled studies are lacking. Read More

    Human papillomavirus infection in oral potentially malignant disorders and cancer.
    Arch Oral Biol 2017 Aug 26;83:334-339. Epub 2017 Aug 26.
    Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People's Republic of China. Electronic address:
    Human papillomavirus (HPV) infects keratinocytes in the mucosa or skin, and persistent infection with HPV may lead to premalignant lesions and invasive cancer, especially cervical cancer. It has also been hypothesized that HPV infection is an etiological factor of oral squamous cell carcinoma and oral precancerous disorders such as lichen planus, leukoplakia, and erythroplakia. A high percentage of HPV in oral lesions supports the possible viral contribution, but an association of HPV infection with these lesions remains to be established. Read More

    Secondary syphilis: The great imitator can't be forgotten.
    Rev Assoc Med Bras (1992) 2017 Jun;63(6):481-483
    MD, General Practitioner, Porto Alegre, RS, Brazil.
    Syphilis is an infection caused by Treponema pallidum, mainly transmitted by sexual contact. Since 2001, primary and secondary syphilis rates started to rise, with an epidemic resurgence. The authors describe an exuberant case of secondary syphilis, presenting with annular and lichen planus-like lesions, as well as one mucocutaneous lesion. Read More

    The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?
    Mol Oral Microbiol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute Seoul National University, Korea.
    Oral lichen planus (OLP) is a variant of LP, a common chronic mucocutaneous inflammatory disease. While cutaneous lesions of LP are self-limiting, OLP lesions are non-remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeutics for this disease. Read More

    Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland.
    Int J Cancer 2017 Aug 31. Epub 2017 Aug 31.
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
    The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. Read More

    Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva.
    BJOG 2017 Aug;124 Suppl 3:87-92
    College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
    Objective: To investigate the short- and long-term efficacy and influential factors of focused ultrasound for the treatment of non-neoplastic epithelial disorders of the vulva (NNEDV).

    Design: A retrospective observational study.

    Setting: A gynaecologic department in a single centre in China. Read More

    Treatment of oral lichen planus using 308-nm excimer laser.
    Dermatol Ther 2017 Aug 23. Epub 2017 Aug 23.
    Department of Dermatology, 404 Hospital of People's Liberation Army, Weihai, Shandong Provence 262200, China.
    Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereby cannot be used in the treatment of OLP. Read More

    What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis.
    Int J Dermatol 2017 Oct 22;56(10):1022-1025. Epub 2017 Aug 22.
    Department of Dermatology, the 1st Affiliated Hospital of Dalian Medical University, Dalian, China.
    Background: Clinical and dermoscopic features of Bowen's disease (BD) show great diversity. Some lesions of BD are often difficult to be differentiated from seborrheic keratosis, actinic keratosis, lichen planus-like keratosis, etc. It is necessary to fully describe the dermoscopic features of the disease, considering differential diagnosis. Read More

    Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 23;124(3):e183-e189. Epub 2017 Jun 23.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:
    Objective: Tumor necrosis factor-α (TNF-α) has a role in the progression of the oral lichen planus (OLP). The aim of this meta-analysis study was to evaluate the salivary and serum TNF-α levels in patients with OLP.

    Study Design: We searched in the databases of PubMed/Medline, Science direct, Scopus, Web of Science, and Cochrane Library for studies reported from 1983 to 2016. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Scoring systems for Oral Lichen Planus used by differently experienced raters.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e562-e571. Epub 2017 Sep 1.
    Division of oral medicine and pathology, Dental Science Department, Ospedale Maggiore, 34100, Trieste, Italy,
    Background: Scoring systems have been widely used to evaluate the severity and activity of oral lichen planus (OLP). The aim of the present study was to compare two existing (one modified) scoring systems in the evaluation of OLP severity and correlation with pain. Three differently experienced raters were involved. Read More

    The role of microRNAs in oral lichenoid disorders. Systematic review.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e548-e553. Epub 2017 Sep 1.
    Oral Medicine, Oral and Maxillofacial Pathology. Department of Stomatology II, University of the Basque Country/ EHU, Leioa, 48940 Bizkaia, Spain,
    Background: Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD).

    Material And Methods: A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA. Read More

    Paraneoplastic Pemphigus. A Life-Threatening Autoimmune Blistering Disease.
    Actas Dermosifiliogr 2017 Aug 8. Epub 2017 Aug 8.
    Servicio de Dermatología, Hospital General de México, Mexico.
    Paraneoplastic pemphigus (PNP), a subset of pemphigus, is a unique autoimmune blistering condition that can affect multiple organs other than the skin. It is a life-threatening disease associated with an underlying malignancy, most commonly of lymphoproliferative origin. The clinical picture may resemble pemphigus, pemphigoid, erythema multiforme, graft-versus-host disease, or lichen planus. Read More

    Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus.
    Indian J Dermatol 2017 Jul-Aug;62(4):440
    National Skin Centre, Department of Dermatology, Singapore.
    Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. Read More

    Lichenoid esophagitis presenting as fatal upper gastrointestinal bleeding in a 52 year-old woman: a case diagnosed by autopsy.
    BMC Gastroenterol 2017 Aug 8;17(1):95. Epub 2017 Aug 8.
    Department of Anatomical Pathology and Cytology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, Quebec, H1T 2M4, Canada.
    Background: "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. Read More

    Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential.
    Clin Oral Investig 2017 Aug 4. Epub 2017 Aug 4.
    School of Dental Medicine, Department of Oral Medicine, University of Zagreb, Zagreb, Croatia.
    Objectives: The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.

    Materials And Methods: Global protein profiling methods based on liquid chromatography coupled to mass spectrometry (LC-MS) were used, with a special emphasis on evaluation of deregulated extracellular matrix molecules expression, as well as on analyses of IG2F and IGFR2 expression in healthy mucosa, OLP and OSCC tissues by comparative semi-quantitative immunohistochemistry.

    Results: Mass spectrometry-based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and accompanied histologically unaltered tissues, respectively) identified 55 extracellular matrix proteins. Read More

    Erosive Lichen Planus.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):407-420
    Department of Dermatology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard #MC-9190, Dallas, TX 75390-7208, USA. Electronic address:
    Lichen planus is an inflammatory mucocutaneous condition with a myriad of clinical manifestations. There are 3 forms of lichen planus that effect the vulva: papulosquamous, hypertrophic, and erosive. Erosive lichen planus can progress to vulvar scaring, vaginal stenosis, and squamous cell carcinoma; these long-term sequelae cause sexual distress, depression, and decreased quality of life for patients. Read More

    Impact of Oral Potentially Malignant Disorders on Quality of Life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Queensland, Australia.
    Background: Oral Potentially Malignant Disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the Quality of Life (QoL) of affected patients.

    Methods: Oral Leukoplakia (OL), Oral Lichen Planus (OLP) and Oral Submucous Fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    Efficacy of low-level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
    Background: Low-level laser therapy (LLLT) has been proposed as a potential treatment strategy for the treatment of oral lichen planus (OLP). The aim of this systematic review was to assess the efficacy of LLLT, in comparison with corticosteroid therapy, in the treatment of OLP.

    Materials And Methods: This systematic review aimed to address the following focused question: "Does LLLT yield better clinical outcomes than corticosteroid therapy in the treatment of OLP?" Indexed databases were searched up to and including April 2017. Read More

    Skin diseases of the vulva: inflammatory, erosive-ulcerating and apocrine gland diseases, zinc and vitamin deficiency, vulvodynia and vestibulodynia.
    J Obstet Gynaecol 2017 Aug 1:1-12. Epub 2017 Aug 1.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described. Read More

    Semaphorin4D drives CD8(+) T cell lesional trafficking in oral lichen planus via CXCL9/CXCL10 upregulations in oral keratinocytes.
    J Invest Dermatol 2017 Jul 28. Epub 2017 Jul 28.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:
    Chemokine mediated CD8(+) T cell recruitment is an essential but not well-established event for the persistence of oral lichen planus (OLP). Semaphorin 4D (Sema4D)/CD100 is implicated in immune dysfunction, chemokine modulation and cell migration, which are critical aspects for OLP progression, but its implication in OLP pathogenesis has not been determined. In this study, we sought to explicate the effect of Sema4D on human oral keratinocytes and its capacity to drive CD8(+) T cell lesional trafficking via chemokine modulation. Read More

    Treatment of oral lichen planus. Systematic review and therapeutic guide.
    Med Clin (Barc) 2017 Jul 27. Epub 2017 Jul 27.
    Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Facultad de Medicina, Universidad de Oviedo, Oviedo, España.
    In this systematic review, 55 structured articles on the therapeutic efficacy against pain and clinical signs of oral lichen planus (OLP) were analysed. The literature search was developed according to the criteria of the PRISMA system, selecting the tests performed using one of the following methodological designs: drug (active ingredient) vs. drug in different excipient or concentration, drug vs. Read More

    Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
    Asian Pac J Cancer Prev 2017 07 27;18(7):1947-1951. Epub 2017 Jul 27.
    Oral and Dental Disease Research Center, Department of Oral Medicine, Zahedan University of Medical Science, Zahedan, Iran. Email:
    The aim of present study was to evaluate salivary matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3 and MMP-13 levels in patients with oral lichen planus (OLP) and squamous cell carcinomas (SCC) as well as in healthy controls. Thirty cases of OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) clinically and histopathologically (group A), 30 with oral SCCs (group B), and 30 with no history of oral cancer, other lesions or lichen planus (group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. Unstimulated whole saliva was collected and laboratory measurement of salivary concentration of MMP-1, MMP-2, MMP-3 and MMP-13 was conducted by immuno-sorbent enzyme-linked methods. Read More

    Topical tocopherol for the treatment of ROLP: randomozed,double-blind crossover study - A query.
    Oral Dis 2017 Jul 26. Epub 2017 Jul 26.
    Dept. of Oral medicine and radiology, KMCT Dental college, Manassery, Mukkam, Calicut.
    In a recently published study "Topical tocopherol for treatment of reticular oral lichen planus: a randomized, double-blind, crossover study" (Oral Diseases, January 2017), the authors have assessed the efficacy of topical tocopherol acetate in improving the lesions and oral discomfort of patient's suffering from reticular oral lichen planus comparing it with the results achievable by administering placebo. ((1)) In the study, 34 patients with clinically diagnosed and histologically confirmed ROLP were randomly assigned to two groups, which received first one of two treatments (treatment 1 or 2) for a month, then the other (treatment 2 or 1) for another month, with a two-week washout between them. One treatment contained tocopherol acetate, the other only liquid paraffin. Read More

    Delivering resveratrol on the buccal mucosa using mucoadhesive tablets: a potential treatment strategy for inflammatory oral lesions.
    Curr Drug Deliv 2017 Jul 26. Epub 2017 Jul 26.
    Faculty of Dentistry, Federal University of Juiz de Fora, 36036-900, Juiz de Fora, MG. Brazil.
    Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. Read More

    Integrative analysis of mRNA and miRNA expression profiles in oral lichen planus: preliminary results.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Objective: Oral lichen planus (OLP), a chronic inflammatory disease of unknown etiology, is considered a potentially malignant oral disorder. The aim of the present study was to analyze candidate microRNAs (miRNAs) and genes from patients with OLP and healthy controls (HCs).

    Study Design: Biopsy specimens of the oral mucosa were collected from patients with OLP (n = 9) and from HCs (n = 4). Read More

    Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Oral Medicine and Dentistry, Brigham and Women's Hospital, Harvard School of Dental Medicine, Boston, MA, USA. Electronic address:
    Objectives: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC.

    Study Design: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC. Cultured human keratinocyte lines from benign oral mucosa, OED, and OSCC, as well as a murine model in which OSCC was induced with 4-nitroquinoline-1-oxide, were also evaluated. Read More

    Mucocutaneous Diseases: Oral Lichen Planus, Mucous Membrane Pemphigoid and Pemphigus Vulgaris.
    J Calif Dent Assoc 2016 09;44(9):561-70
    Mucocutaneous diseases affect the oral cavity and can present a diagnostic challenge. They can have systemic involvement, necessitating multidisciplinary management. Frequently, patients will see their general dentists initially for evaluation. Read More

    IL-17A polymorphism and elevated IL-17A serum levels are associated with oral lichen planus.
    Oral Dis 2017 Jul 25. Epub 2017 Jul 25.
    Centro de Ensino e Pesquisa de Laser em Odontologia - CEPLO. Programa de Pós-graduação em Odontologia, Universidade Federal de Pernambuco.
    Objective: The aim of this study was to evaluate the association of IL-17A G197A polymorphism and serum levels with oral lichen planus susceptibility and clinical presentation.

    Subjects And Methods: Eighty three individuals diagnosed with oral lichen planus (OLP) and ninety nine healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL-17A (G197A) genotyping. Read More

    Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 30;124(3):248-252. Epub 2017 May 30.
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:
    Objective: Many patients with oral lichen planus (OLP) report triggers of flares, some of which overlap with triggers of other oral diseases, including oral allergy syndrome and oral contact dermatitis. The purpose of this study was to evaluate the prevalence of commonly reported triggers of OLP flares, their overlap with triggers of other oral diseases, and the potential role of trigger avoidance as a management strategy.

    Study Design: Questionnaire-based survey of 51 patients with biopsy-proven lichen planus with oral involvement seen in an academic dermatology specialty clinic and/or oral pathology clinic between June 2014 and June 2015. Read More

    Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases.
    J Am Acad Dermatol 2017 Oct 14;77(4):683-690.e2. Epub 2017 Jul 14.
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
    Background: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men.

    Objective: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients.

    Methods: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. Read More

    The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis.
    J Am Dent Assoc 2017 Jul 13. Epub 2017 Jul 13.
    Background: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants.

    Methods: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. Read More

    Incidence of Oral Lichen Planus in Perimenopausal Women: A Cross-sectional Study in Western Uttar Pradesh Population.
    J Midlife Health 2017 Apr-Jun;8(2):70-74
    Department of Oral Medicine and Radiology, Subharti Dental College, Meerut, Uttar Pradesh, India.
    Background: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Salivary levels of interleukin-8 in oral lichen planus and diabetic patients: A biochemical study.
    Dent Res J (Isfahan) 2017 May-Jun;14(3):209-214
    Dentist, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: This study aimed to assess the salivary levels of interleukin-8 (IL-8) in oral lichen planus (OLP) and diabetes mellitus (DM) patients, and OLP + DM patients in comparison with healthy individuals.

    Materials And Methods: This descriptive cross-sectional study was conducted on 75 patients (30 with OLP, 5 with both OLP and DM, 20 with DM and 20 healthy controls). The salivary levels of IL-8 and fasting blood sugar and 2-h postprandial blood glucose levels were measured in all the subjects. Read More

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