10,377 results match your criteria Lichen Planus

Narrow Band Imaging features of oral lichenoid conditions: a multicentre retrospective study.

Oral Dis 2021 May 13. Epub 2021 May 13.

Australian Centre for Oral Oncology Research & Education, Perth, WA, Australia.

Objective: Narrow Band Imaging (NBI) which highlights epithelial Intrapapillary Capillary Loops (IPCLs) classified into five patterns (0 to IV) with increasing correlation to malignancy, has demonstrated effectiveness for detection of Oral Squamous Cell Carcinoma (OSCC). Lack of standardized procedures limits its use for routine inspection of oral lichenoid lesions including Oral Lichen Planus (OLP), Oral Lichenoid Lesion (OLL) and Oral Lichenoid Reaction (OLR). The aim of this study was to analyze IPCL patterns of such lesions, assessing correlations with histopathological outcomes. Read More

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Laryngeal lichen planus mimicking vocal fold dysplasia.

Auris Nasus Larynx 2021 May 5. Epub 2021 May 5.

Otolaryngology Unit, Head and Neck Surgery, ASST del Garda, Manerbio Hospital, Brescia, Italy.

Lichen planus (LP) is an immune-mediated chronic inflammatory disease affecting the skin and mucosal membranes, either alone or in combination. LP rarely occurs in the larynx, where it presents as leukoplakia. Additionally, due to its responsiveness to corticosteroid drugs, differential diagnosis from other causes of laryngeal leukoplakia is needed (e. Read More

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Georgian Med News 2021 Mar(312):71-74

Tbilisi State Medical University, department of dermatology and venerology, Georgia.

The clinical picture and course of lichen planus (LP) on the mucous membrane of the oral cavity have significant differences from its manifestations on the skin. In particular, greater resistance to treatment, which is due to the structural features of the mucous membrane, as well as the specificity of biological and physicochemical processes in the oral cavity. There are 6 clinical forms of LP of the red border of the lips and oral mucosa - typical, hyperkeratotic, exudative-hyperemic, erosive - ulcerative, bullous and atypical. Read More

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Nail Lichen Planus.

Mayo Clin Proc 2021 05;96(5):1363-1364

Department of Dermatology, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address:

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Isolated Perianal Erosive Lichen Planus: A Diagnostic Challenge.

Cutis 2021 Mar;107(3):E40-E42

Drs. Santiago, Nevarez, Falto-Aizpurua, and Colon-Fontanez are from the Department of Dermatology, University of Puerto Rico, Medical Sciences Campus, San Juan. Dr. Candelario is from Hato Rey Pathology Associates, Inc, San Juan.

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New markers of oxidative stress in lichen planus and the influence of hepatitis C virus infection - a pilot study.

Rom J Intern Med 2021 May 5. Epub 2021 May 5.

"Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021Bucharest, Romania.

Introduction: Lichen planus (LP) is a mucocutaneous T-cell mediated disorder of unknown etiology. There is growing evidence that oxidative stress is an important player in the pathogenesis of LP. Therefore, we have investigated oxidative stress markers in LP and the influence of hepatitis C virus (HCV) infection, a frequently associated condition, on oxidative stress in LP patients. Read More

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Psychosocial burden of lichen planus pigmentosus is similar to vitiligo, but greater than melasma: A cross-sectional study from a tertiary-care center in north India.

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):341-347

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Lichen planus pigmentosus can have a negative impact on the quality of life; however, this has not been studied in detail.

Objectives: To study the quality of life in patients with lichen planus pigmentosus and compare it with patients with vitiligo and melasma.

Methods: This was a cross-sectional study conducted in a tertiary-care center in north India from January 2018 to May 2019. Read More

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October 2019

Correlation of Mast Cell and Angiogenesis in Oral Lichen Planus, Dysplasia (Leukoplakia), and Oral Squamous Cell Carcinoma.

Rambam Maimonides Med J 2021 Apr 29;12(2). Epub 2021 Apr 29.

Oral and Maxillofacial Surgery, Asan Memorial Dental College and Hospital, Keerapakkam Village, Asan Nagar, Chengalpattu, India.

Objective: The aim of this study was to compare and correlate mast cell density (MCD) and microvessel density (MVD) between normal oral mucosa, oral lichen planus, various grades of dysplasia, and oral squamous cell carcinoma (OSCC).

Materials And Methods: The study comprised a total of 75 samples, of which 65 were archival tissue blocks of histopathologically confirmed cases, which included 10 cases of oral lichen planus, 25 cases of dysplasia (mild [n=10], moderate [n=10], and severe [n=5]), and 30 cases of OSCC (well differentiated [n=10], moderately differentiated [n=10], and poorly differentiated [n=10]), and 10 samples of normal oral mucosa. All the sections were immunohistochemically stained with anti-CD34 and counterstained with toluidine blue stain. Read More

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Lichen Planus Pigmentosus Associated with Topical Olive Oil Application.

Skinmed 2021 1;19(2):142-144. Epub 2021 Apr 1.

Department of Gastroenterology, Hotel-Dieu de France University Hospital, Beirut, Lebanon.

A 45-year-old brown-skinned woman presented with a 5-year history of asymptomatic grayish brown lesions on the face, arms, and legs. She had no medical history of previous diseases or contact dermatitis. She revealed that she had used olive oil all over her body for the last 8 years every other day. Read More

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The importance of dermoscopy in subclinical lichen planus in skin of color.

Int J Womens Dermatol 2021 Mar 9;7(2):205-206. Epub 2021 Jan 9.

Chroma Dermatology, Pigment and Skin of Colour Centre, Melbourne, Victoria, Australia.

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A Deep Learning Based Framework for Diagnosing Multiple Skin Diseases in a Clinical Environment.

Front Med (Lausanne) 2021 16;8:626369. Epub 2021 Apr 16.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on the classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. This study was aimed to construct a novel framework based on deep learning trained by a dataset that represented the real clinical environment in a tertiary class hospital in China, for better adaptation of the AI application in clinical practice among Asian patients. Read More

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Gastroenterology 2021 Apr 27. Epub 2021 Apr 27.

Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá. Madrid, Spain.

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Inter-Observer and Intra-Observer Variations in the Assessment of Epithelial Dysplasia in Oral Lichenoid Diseases.

Dermatopathology (Basel) 2021 Apr 1;8(2):84-88. Epub 2021 Apr 1.

Department of Dermatology, Inselspital Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland.

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) can both present with histological dysplasia. Despite the presence of WHO-defined criteria for the evaluation of epithelial dysplasia, its assessment is frequently subjective (inter-observer variability). The lack of reproducibility in the evaluation of dysplasia is even more complex in the presence of a lichenoid inflammation. Read More

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Clinical and dermatoscopic features of lichen planus balanoposthitis.

Clin Exp Dermatol 2021 Apr 29. Epub 2021 Apr 29.

Department of Internal Diseases, Riga Stradins University, Riga, Latvia.

Lichen planus (LP) is an inflammatory mucocutaneous disease characterized by pruritic, polygonal, violaceous, flat-topped papules. Wickham striae (WS) are a dermatoscopic and clinical hallmark of LP. Additional dermatoscopic findings include dotted and linear vessels, white and yellow dots, and pigmented structures. Read More

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Lichen Planus and Alopecia Areata Co-Localization.

Sabha Mushtaq

Indian J Dermatol 2021 Jan-Feb;66(1):101-103

Department of Dermatology, Venereology and Leprology, Government Medical College, Jammu, Jammu and Kashmir, India. E-mail:

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The Role of Patch Testing with Indian Cosmetic Series in Patients with Facial Pigmented Contact Dermatitis in India.

Indian J Dermatol 2021 Jan-Feb;66(1):81-86

Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.

Background: Pigmented contact dermatitis (PCD) is a non-eczematoid variant of contact dermatitis, mainly characterised by hyperpigmentation. It occurs due to contact with a low amount of allergen over a long duration of time. PCD is frequently seen in Indians but is often misdiagnosed or underdiagnosed because of the asymptomatic nature of the entity. Read More

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Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review.

Ethiop J Health Sci 2020 Jul;30(4):615-622

Dentist, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Oral lichen planus (OLP) is known to be a chronic inflammatory disease associated with various other systemic disorders. Studies have shown that vitamin D deficiency can be involved in the pathogenesis of lichen planus. The aim of this study was to investigate the role of vitamin D and vitamin D receptor in OLP. Read More

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Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.

Cancer Biomark 2021 Apr 12. Epub 2021 Apr 12.

Background: Oral squamous cell carcinoma (OSCC) usually originates from oral potentially malignant disorders (OPMD), such as oral leukoplakia (OLK) and oral lichen planus (OLP). Identifying biomarkers for the early diagnosis and evaluation of malignant transformation in OPMD could improve the survival rate of OSCC patients.

Objective: The present study aimed to screen for potential salivary biomarkers for evaluating the malignant transformation of OPMD. Read More

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Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition.

BMC Microbiol 2021 Apr 20;21(1):122. Epub 2021 Apr 20.

Key Laboratory for Experimental Teratology of Ministry of Education and Department of Microbiology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.

Background: Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Read More

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Tacrolimus inhibits oral carcinogenesis through cell cycle control.

Biomed Pharmacother 2021 Apr 16;139:111545. Epub 2021 Apr 16.

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, PR, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, PR, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR, China. Electronic address:

Tacrolimus (TAC, FK506) is a major calcineurin inhibitor and has been commonly used in treatments of patients with organ transplants and immune diseases. Moreover, tacrolimus is recommended by the treatment guidelines for oral potentially malignant disorders (OPMDs) such as oral lichen planus (OLP). However, whether tacrolimus increases the risk of cancer remains controversial. Read More

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Evaluation of corneal densitometry changes in patients with lichen planus.

Int J Clin Pract 2021 Apr 19:e14234. Epub 2021 Apr 19.

Department of Ophthalmology, University of Health Scıences Gazi Yaşargil Education Research Hospital, Diyarbakır, Turkey.

Purpose: To investigate the corneal topography and densitometry changes in patients with lichen planus (LP).

Methods: Anterior segment parameters and corneal densitometry of patients with LP and age- and gender-matched individuals with healthy eyes were evaluated using Scheimpflug corneal topography. A 12 mm corneal area was divided into 4 annular zones and 3 regions-in-depth anterior, central and posterior-for densitometry evaluation. Read More

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From Simple Mouth Cavities to Complex Oral Mucosal Disorders-Curcuminoids as a Promising Therapeutic Approach.

ACS Pharmacol Transl Sci 2021 Apr 17;4(2):647-665. Epub 2021 Mar 17.

Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India.

Oral diseases are among the most common encountered health issues worldwide, which are usually associated with anomalies of the oral cavity, jaws, and salivary glands. Despite the availability of numerous treatment modalities for oral disorders, a limited clinical response has been observed because of the inefficacy of the drugs and countless adverse side effects. Therefore, the development of safe, efficacious, and wide-spectrum therapeutics is imperative in the battle against oral diseases. Read More

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Patch test of dental materials in Oral Lichen Planus with considering the role of saliva.

Sci Rep 2021 Apr 15;11(1):8264. Epub 2021 Apr 15.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Lichen planus is the most common skin disease that affects the oral mucosa. Oral Lichen Planus is a T-cell-mediated autoimmune disorder. In the current study, for the first time, an oral cavity condition in skin patch tests with adding saliva is simulated. Read More

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Lichen planus eruption following annual influenza vaccination.

JAAD Case Rep 2021 Apr 10;10:116-118. Epub 2021 Mar 10.

Skin and Cancer Associates, Plantation, Florida.

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FoxP3CD4, IFN-γCD4, and IFN-γCD8 cell levels in erosive and non-erosive types of oral lichen planus patients.

J Dent Sci 2021 Mar 27;16(2):751-756. Epub 2021 Jan 27.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background/purpose: Oral lichen planus (OLP) is a localized autoimmune oral mucosal disease. This study evaluated whether different types of OLP patients including erosive OLP (EOLP), major EOLP, minor EOLP, and non-erosive OLP (NEOLP) patients had significantly higher percentages of FoxP3CD4 or IFN-γCD4 cells in total CD4 cells, and of IFN-γCD8 cells in total CD8 cells than healthy control subjects and whether the patient's age had significant influences on these cell percentages in OLP patients.

Materials And Methods: Flow cytometry was used to count the FoxP3CD4, IFN-γCD4, or IFN-γCD8 cell levels in 183 OLP patients (67 major EOLP, 81 minor EOLP, and 35 NEOLP patients) and 20 healthy control subjects. Read More

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Efficacy of Herbal Interventions in Oral Lichen Planus: A Systematic Review.

Contemp Clin Dent 2020 Oct-Dec;11(4):311-319. Epub 2020 Dec 20.

Department of Periodontology, Sharad Pawar Dental College, DMIMS DU, Sawangi (Meghe), Wardha, Maharashtra, India.

Introduction: Oral lichen planus (OLP) is a chronic autoimmune condition requiring prompt treatment to alleviate the signs and symptoms. There is weak evidence emphasizing the efficacy of any one therapy. Steroids, of all the therapies, have proved to be effective and hence considered as the standard care for OLP. Read More

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December 2020

The effect of plaque control in the treatment of Oral Lichen Planus with gingival manifestations: a Systematic Review.

Community Dent Health 2021 Apr 9. Epub 2021 Apr 9.

Centre for Host Microbiome Interactions, Kings College, London.

Background: Oral lichen planus (OLP) is a chronic autoimmune disease that frequently affects the oral mucosa. Patients with OLP tend to present with plaque accumulation which may further exacerbate the lichenoid lesion, thus plaque control may improve the quality of life of patients. The aim of this review was to test the effect of plaque control on OLP with gingival manifestations. Read More

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