9,097 results match your criteria Lichen Planus


Vulvar Lichen Planus: A Risk Factor for Vulvar High-Grade Squamous Intraepithelial Lesion Recurrence?

J Low Genit Tract Dis 2018 Jul;22(3):264-265

Department of Obstetrics and Gynecology, University of Torino, Torino, Italy Department of Obstetrics and Gynecology, University of Torino, Torino, Italy; Department of Pathology, and Cytology of Female Cancer, Childhood Cancer and Rare Cancers, AOU Città della Salute e della Scienza, Torino, Italy Department of Obstetrics and Gynecology, University of Torino, Torino, Italy Romagna Cancer Registry,Romagna Cancer Institute, Meldola, Forlì, Italy.

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Female Genital Itch.

Dermatol Clin 2018 Jul 26;36(3):225-243. Epub 2018 Apr 26.

Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:

Vulvar pruritus is a common complaint among young girls and women presenting to primary care physicians, gynecologists, and dermatologists. Female genital itch is especially disruptive because of its interference with sexual function and intimacy. Causes of vulvar itch are vast and may be inflammatory, environmental, neoplastic, or infectious, often with several causes coexisting simultaneously. Read More

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Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa.

Biomaterials 2018 Jun 14;178:134-146. Epub 2018 Jun 14.

School of Clinical Dentistry, The University of Sheffield, S10 2TA, Sheffield, UK.

Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment often necessitates the use of steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion. Here we evaluate the performance of novel mucoadhesive patches for targeted drug delivery. Read More

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June 2018
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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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Increased expression of p16 in both oral and genital lichen planus.

Med Oral Patol Oral Cir Bucal 2018 Jun 20. Epub 2018 Jun 20.

Department of Odontology Umeå University SE - 901 85 Umeå Sweden

Background: Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 and thus down regulate cell cycle progression. Read More

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Lichen planus: a rare cause of a narrowed esophagus.

J Gastrointestin Liver Dis 2018 Jun;27(2):117

Division of Gastroenterology and Hepatology,Mayo Clinic, Rochester, MN, USA.

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Therapeutic Potential of Enoxaparin in Lichen Planus: Exploring Reasons for Inconsistent Reports.

Front Pharmacol 2018 5;9:586. Epub 2018 Jun 5.

Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia.

Lichen planus (LP) is an uncommon mucocutaneous inflammatory condition, that is immunologically mediated, typically pruritic and often recurs. The currently advocated therapies are either not highly effective or associated with severe side effects. Enoxaparin, a widely used anticoagulant, is composed of both anticoagulant and non-anticoagulant fragments. Read More

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Linear bullous lichen planus associated with nivolumab.

Clin Exp Dermatol 2018 Jun 19. Epub 2018 Jun 19.

Dermatology Unit, Department of Medicine (DIMED), University of Padua, Via Gallucci 4, 35128, Padua, Italy.

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Zosteriform Lichen Planus Pigmentosus Altering Segmental Vitiligo.

Skinmed 2018 1;16(2):133-135. Epub 2018 Apr 1.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A 22-year-old student presented with a 3-year history of hyperpigmented, minimally pruritic skin lesions over his trunk. They had begun as small discrete macules over the left side of the trunk, with some coalescing to form patches. He had had right-sided segmental vitiligo (SV) for the previous 7 to 8 years (Figure 1A), and this had started to cross the midline, covering a margin over the left side of the chest and back. Read More

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April 2018
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Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial.

Clin Oral Investig 2018 Jun 16. Epub 2018 Jun 16.

Department of Oral Pathology, Faculty of Dentistry, Ain-Shams University, Cairo, Egypt.

Objectives: Oral lichen plans (OLP) is a potentially malignant inflammatory mucocutaneous disease. CD133 is an investigated surface marker for cancer stem-like cells (CSCs) that may be involved in tumor initiation in head and neck carcinomas. We compared short-term clinical effectiveness of topical pimecrolimus as selective inflammatory cytokine release inhibitor with betamethasone cream for erosive/atrophic OLP and investigated the influence of this therapy on CD133 expression. Read More

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Beltlike lichen planus pigmentosus complicated with focal amyloidosis.

Cutis 2018 May;101(5):E24-E26

Department of Dermatology, First Affiliated Hospital, Nanjing Medical University, China.

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Altered HMGB1 distribution in patients with lichen planus.

Eur J Dermatol 2018 Jun 8. Epub 2018 Jun 8.

China-Japan Union Hospital Of Jilin University, Changchun, China.

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June 2018
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Photodermatoses in skin of color.

J Eur Acad Dermatol Venereol 2018 Jun 10. Epub 2018 Jun 10.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Photodermatoses represent a heterogeneous collection of disorders unified by the characteristic of being provoked through exposure to ultraviolet radiation. Generally, these conditions are classified into the following categories: immunologically mediated photodermatoses, chemical- and drug-induced photosensitivity, photoaggravated dermatoses, and photosensitivity associated with defective DNA repair mechanisms or chromosomal instabilities. The list of photodermatoses is extensive and each individual photodermatosis is understood to a different extent. Read More

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June 2018
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The importance of topical steroids after adhesiolysis in erosive lichen planus and graft versus host disease.

J Obstet Gynaecol 2018 Jun 8:1-4. Epub 2018 Jun 8.

a Department of Gynaecological Oncology , Guy's and St Thomas NHS Trust , London , UK.

The aim of this study was to assess the efficacy of a postoperative steroid regimen in maintaining vulvovaginal architecture and vaginal patency following surgical adhesiolysis in severe erosive lichen planus (ELP) and genital graft versus host disease (GVHD). Sixteen women applied potent topical steroids to the vulva and vagina from 48 hours after surgery. Sexual and urinary function and vulvovaginal anatomy were assessed at 6 weeks, 6, 12 and 24 months. Read More

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Oral lichen planus and HPV lesions.

Pan Afr Med J 2018 24;29:74. Epub 2018 Jan 24.

University of Milan, Department of Radiology, Milano, Italy.

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January 2018

Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus.

Open Access Maced J Med Sci 2018 May 18;6(5):879-884. Epub 2018 May 18.

Oral Medicine and Periodontology Dep., Faculty of Dentistry, Cairo University, Cairo, Egypt.

Aim: The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP).

Methods: Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group). Read More

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May 2018
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New biochip immunofluorescence test for the serological diagnosis of pemphigus vulgaris and foliaceus: A review of the literature.

Int J Womens Dermatol 2018 Jun 3;4(2):102-108. Epub 2018 Feb 3.

Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia.

The immunoassays that are available for the serological diagnosis of the more common subtypes of autoimmune blistering diseases such as pemphigus vulgaris (PV) and pemphigus foliaceus (PF) include enzyme-linked immunosorbent assay (ELISA) testing to specific antigens desmoglein (Dsg)1 and Dsg3, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and immunoblotting. A review of the literature on the biochip assay was conducted. Six studies investigated the validity of a new biochip, mosaic-based, IIF test in patients with pemphigus and demonstrated its relatively high sensitivity and specificity (Dsg3: 97. Read More

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Effectiveness of 904nm Gallium-Arsenide Diode Laser in Treatment of Oral Lichen Planus: Report of 2Cases.

Actas Dermosifiliogr 2018 May 29. Epub 2018 May 29.

Profesor, Departamento de Medicina Oral y Radiología, Facultad JSS Dental, Mysore, Karnataka, India.

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Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association?

Dermatol Ther (Heidelb) 2018 May 31. Epub 2018 May 31.

Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Naples, Italy.

Lichen planus (LP) is a chronic inflammatory disease that affects the skin and oral mucosa. Although its etiology is unknown, its potential for cancerization has been confirmed. We herein report the cases of a brother and sister, both with a 15-year history of nail lichen planus of the fingers and toes, who developed squamous cell carcinomas of the nail bed and matrix. Read More

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Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus.

J Dent (Shiraz) 2018 Jun;19(2):118-123

Dentist, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.

Statement Of The Problem: Oral lichen planus is a common mucocutaneous lesion with a chronic inflammatory process mediated by immune factors while a few cases of the disease become malignant.

Purpose: This study aimed to determine the frequency of p53 marker as a tumor suppressor in patients with erosive and non-erosive oral lichen planus (OLP) by using immunohistochemical methods.

Materials And Method: This descriptive cross-sectional study investigated the p53 expression in 16 erosive OLP, 16 non-erosive OLP samples, and 8 samples of normal oral mucosa through immunohistochemistry. Read More

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Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus.

Biomed Pharmacother 2018 May 28;105:151-158. Epub 2018 May 28.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Haidian, Beijing 100081, PR China. Electronic address:

Mesenchymal stem cells (MSCs) have been used clinically and experimentally to relieve severe immune-related diseases due to their immunomodulatory properties, but these are impaired by inflammation. Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease. In the present study, we found MSCs from OLP with higher expression of interleukin (IL)-6, tumour necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β) and IL-10 compared with control. Read More

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Oral Verruciform Xanthoma within Lichen Planus: A Case Report and Literature Review.

Case Rep Dent 2018 22;2018:1615086. Epub 2018 Apr 22.

Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Background: Verruciform xanthoma is an uncommon benign tumor, which exhibits a wide range of clinical patterns. The occurrence of the lesion in patients with immune-mediated mucocutaneous diseases may suggest a role of localized epithelial cell damage and chronic inflammation in its pathogenesis.

Case Report: A case of verruciform xanthoma on the tongue of a 56-year-old female with oral lichen planus is reported. Read More

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Potentially Malignant Oral Disorders and Cancer Transformation.

Anticancer Res 2018 Jun;38(6):3223-3229

Department of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Cancer in the oral cavity is often preceded by precursor lesions. Nine oral mucosal disorders are known to have an increased risk of malignant transformation. The etiology varies from disorders caused by exogenous factors such as tobacco and autoimmune inflammation to idiopathic or inherited genetic aberrations. Read More

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MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2).

Med Sci Monit 2018 May 29;24:3591-3603. Epub 2018 May 29.

Department of Geriatrics, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China (mainland).

BACKGROUND A wide range of microRNAs (miRNAs) have been shown to play a significant role in disease regulation. The objective of this study was to explore the role of miR-155 and miR-19a in the regulation of oral lichen planus (OLP). MATERIAL AND METHODS Microarray assay, real-time PCR, Western blot assay, computational analysis, luciferase assay, ELISA, and immunohistochemistry analysis were carried out to investigate the role of miR-155 and miR-19a in OLP. Read More

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May 2018
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Expression and clinical significance of periostin in oral lichen planus.

Exp Ther Med 2018 Jun 3;15(6):5141-5147. Epub 2018 Apr 3.

Department of Pathology, First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Oral lichen planus (OLP) is a chronic inflammatory lesion involving the oral mucosa, which has a high likelihood of progressing to cancer. The present study investigated the periostin expression in the mucosa and serum of patients with OLP and its correlation with serum cytokines. A total of 117 patients with OLP and 110 healthy controls were included in the study. Read More

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Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments

Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. Epub 2018 May 26.

Dental Research Center AND Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Email:

Oral lichen planus (OLP) is an immune-related disorder with unknown exact etiology but established prevalence in females. There are six clinical forms of OLP, ranging from asymptomatic white keratotic lesions to painful erosions and ulcerations. The aim of the present report is to overview pathologic and therapeutic aspects. Read More

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May 2018
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Dental Implants and Oral Lichen Planus.

J Prosthodont 2018 May 25. Epub 2018 May 25.

Maxillo-Facial and Dental Unit (Head Prof. AB Gianni), Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milan, Italy.

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Detection of lichen planus pigmentosus with dermoscopy and reflectance confocal microscopy.

Skin Res Technol 2018 May 23. Epub 2018 May 23.

Department of Dermatology, The Third People's Hospital of Hangzhou, Hangzhou, Zhejiang, China.

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An Update on Drug-induced Oral Reactions.

J Pharm Pharm Sci 2018 ;21(1):171-183

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. Electronic searches were performed in Scopus, Google Scholar, Cochrane and PubMed databases, for articles published between January 2008 and August 2017. Read More

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January 2018
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Unusual ocular presentation in a patient with lichen planus.

Authors:
Samir S Shoughy

Can J Ophthalmol 2018 Jun 23;53(3):e122-e124. Epub 2017 Nov 23.

The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia. Electronic address:

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Activation of Herpes Simplex Infection after Tattoo.

Acta Dermatovenerol Croat 2018 Apr;26(1):75-76

Antigona Begolli Gerqari, MD, Dermatovenerology Clinic, University Clinical Center 10000 Pristina , Republic of Kosovo;

Tattooing is a procedure where ink is applied to an area of the skin, mostly intraepidermally (1). This procedure is carried out mainly for aesthetic purposes. Lately, it has been used as a corrective medical procedure following amputation of mammilla. Read More

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April 2018
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Role of In Vivo Reflectance Confocal Microscopy in the Analysis of Melanocytic Lesions.

Acta Dermatovenerol Croat 2018 Apr;26(1):64-67

Elena-Daniela Serban, MD, Department of Medical Oncology, University of Bologna, 40138 Bologna; Italy.

Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. Read More

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April 2018
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Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

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April 2018
3 Reads

Palmoplantar lichen planus-like eruption in a patient with graft-versus-host disease: Is it rare presentation of chronic graft-versus-host disease?

J Dermatol 2018 May 21. Epub 2018 May 21.

Department of Dermatology, Seoul National University Hospital, Seoul, Korea.

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May 2018
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Janus Kinase Inhibitors: A Review of Their Emerging Applications in Dermatology

Skin Therapy Lett 2018 05;23(3):5-9

Division of Dermatology, University of Calgary, Calgary, AB, Canada.

The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and normal cell growth. This class includes the drugs tofacitinib, approved for the treatment of rheumatoid arthritis, and ruxolitinib, approved for the treatment of myelofibrosis and polycythemia rubra vera. The most common adverse events (AEs) reported in patients taking tofacitinib are infections, whereas the most common AEs in patients taking ruxolitinib are anemia and thrombocytopenia. Read More

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May 2018
2 Reads

Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

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Joint recommendations for retinal screening in long-term users of hydroxychloroquine and chloroquine in the United Kingdom (2018).

Br J Dermatol 2018 May 16. Epub 2018 May 16.

Department of Dermatology, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire, SO16 6YD.

Hydroxychloroquine has become established in the management of various forms of cutaneous lupus, photosensitive dermatoses, porphyria cutanea tarda, cutaneous sarcoid, lichen planus and other inflammatory dermatological diseases. Dermatologists who prescribe hydroxychloroquine should be aware of new recommendations for retinal screening in all patients on long-term hydroxychloroquine and chloroquine in the United Kingdom. The recommendations have been published by the Royal College of Ophthalmologists following a systematic review of the current evidence with input from representatives from the British Society for Rheumatology (BSR) and the British Association of Dermatologists (BAD) (Dr. Read More

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Graft versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pathophysiological Understanding of Cicatricial Pattern Hair Loss.

Int J Trichology 2018 Mar-Apr;10(2):80-83

Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.

A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA). Read More

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An open-label non-randomized prospective pilot study of the efficacy of Q-switched Nd-YAG laser in management of facial lichen planus pigmentosus.

J Cosmet Laser Ther 2018 May 16:1-8. Epub 2018 May 16.

c Nital Skin Clinic , Karad , India.

Lichen planus pigmentosus (LPP) is a cosmetically disfiguring condition. Many treatment options are available which are effective in halting the progression of the disease. The treatment of persistent pigmentation is still a challenge. Read More

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Unique causes of esophageal inflammation: a histopathologic perspective.

Ann N Y Acad Sci 2018 May 16. Epub 2018 May 16.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Gastroenterologists frequently perform endoscopic esophageal mucosal biopsies for pathologic diagnosis in patients experiencing symptoms of esophagitis. The more common causes of esophagitis diagnosed on esophageal mucosal biopsy include reflux esophagitis, eosinophilic esophagitis, and infectious esophagitis caused by Candida albicans, herpes simplex virus, and/or cytomegalovirus. However, there are several causes of esophagitis seen less frequently by pathologists that are very important to recognize. Read More

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May 2018
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Comment on "Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids".

Open Dent J 2018 30;12:310-311. Epub 2018 Apr 30.

Dental Research Center, Department of Oral Medicine / School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

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April 2018
2 Reads

Heparinoid suppresses Der p-induced IL-1β production by inhibiting ERK and p38 MAPK pathways in keratinocytes.

Exp Dermatol 2018 May 13. Epub 2018 May 13.

Department of Dermatology, Ehime University Graduate School of Medicine Shitsukawa, Toon City, Ehime, 791-0295, Japan.

Epidermal keratinocytes initiate skin inflammation by activating immune cells. The skin barrier is disrupted in atopic dermatitis (AD) and epidermal keratinocytes can be exposed to environmental stimuli, such as house dust mite (HDM) allergens. We showed previously that HDM allergens activate the NLRP3 inflammasome of keratinocytes, thereby releasing pro-inflammatory cytokines. Read More

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Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus.

J Formos Med Assoc 2018 May 9. Epub 2018 May 9.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) have not yet been reported in recurrent aphthous stomatitis (RAS) patients with concomitant oral lichen planus (OLP/RAS patients). This study mainly assessed the frequencies of serum GPCA, TGA, and TMA (GPCA/TGA/TMA) positivities in 44 OLP/RAS patients.

Methods: The frequencies of serum GPCA/TGA/TMA positivities in 44 OLP/RAS patients, OLP/RAS patients of four different subgroups, 520 RAS patients, and 352 healthy control subjects were calculated and compared. Read More

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Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis.

Clin Exp Dent Res 2017 Dec 7;3(6):220-226. Epub 2017 Nov 7.

Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen Denmark.

The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty-nine patients and 29 healthy age- and gender-matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-6, IL-10, IL-12p40, and IL-12p70 were analyzed and compared between groups. Read More

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December 2017

Rate of malignant transformation of Oral Lichen Planus: a systematic review.

Oral Dis 2018 May 8. Epub 2018 May 8.

School of Dentistry, Catholic University of the Sacred Heart, Rome, Italy.

Objective: The aim of this study is to systematically review the literature to determine: 1) the malignant transformation rate (TR) of Oral Lichen Planus (OLP) and its risk factors; 2) whether or not Oral Lichenoid Lesions (OLL) have a different malignant TR.

Materials And Methods: PubMed, Scopus and Web of Science were used as search engines: only observational, full-length, English language studies were investigated. PRISMA protocol was used to evaluate and present results. Read More

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May 2018
2 Reads

Validity and reliability of the persian version of the chronic oral mucosal diseases questionnaire.

Caspian J Intern Med 2018 ;9(2):127-133

Department of Oral Medicine, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.

Background: Chronic oral mucosal disease uestionnaire (COMDQ) is used to evaluate the quality of life in patients with chronic conditions of the oral mucosa. The aim of the present study was to evaluate the validity and reliability of the Persian version of this questionnaire.

Methods: A total of 135 subjects were selected in two groups; group 1 consisted of 95 patients with chronic oral mucosal conditions, including recurrent aphthous stomatitis, oral lichen planus and pemphigus and mucous membrane pemphigoid and group 2 consisted of 40 patients with other oral diseases. Read More

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January 2018

Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential.

Exp Ther Med 2018 May 20;15(5):4157-4166. Epub 2018 Mar 20.

Post-Graduation Program in Medical Sciences, Department of Pathology, School of Medicine, University of Brasília, Brasília 70910-900, Brazil.

The association of oral lichen planus (OLP) lesions with malignant transformation risk has remained a controversial topic and is of clinical importance. Therefore, the present study evaluated the expression levels of p16, Ki-67, budding uninhibited by benzimidazoles 3 (Bub-3) and sex-determining region Y-related high mobility group box 4 (SOX4), and their roles as precancerous biomarkers in OLP. A retrospective study was performed, in which tissue blocks of OLP, oral dysplasia (OD), cutaneous lichen planus (CLP) and oral fibrous hyperplasia (OFH) were used (n=120). Read More

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Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study.

Cent Eur J Immunol 2018 30;43(1):103-108. Epub 2018 Mar 30.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Interleukin-6 (IL-6) is a cytokine that contributes to the pathogenesis of oral lichen planus (OLP). The aim of this meta-analysis study is the evaluation of IL-6 levels in the serum and saliva of patients with OLP compared with healthy controls. We searched the studies in 5 databases: PubMed/Medline, Scopus, ScienceDirect, Web of Science, and Cochrane Library, from 1983 to Oct 31, 2016. Read More

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Up-regulation of HMGB1 and TLR4 in skin lesions of lichen planus.

Arch Dermatol Res 2018 May 4. Epub 2018 May 4.

Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of São Paulo, LIM-56, Av. Dr. Enéas de Carvalho Aguiar, 470, 3rd floor, São Paulo, 05403-000, Brazil.

Lichen planus (LP) is a chronic, mucocutaneous inflammatory disease of an unknown aetiology. The disease has been associated with certain viruses, and the factors such as DAMPs (damage-associated molecular patterns) and PAMPs (pathogen-associated molecular patterns) may also contribute to the inflammatory response in LP. HMGB1 (high mobility group box 1 protein) is one of the major DAMPs that induces inflammation and could trigger LP disease. Read More

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May 2018
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