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    VEGFR-3 Expression in Oral Lichen Planus
    Asian Pac J Cancer Prev 2017 02 1;18(2):381-384. Epub 2017 Feb 1.
    Oral and Maxillofacial Pathology Department, Dental Faculty, Babol University of Medical Sciences, Babol, Iran.
    Background and objective: Given the postulated the role of inflammation and possible contribution of lymphangiogenesis in oral lichen planus, this study aimed to assess any associated presence of VEGFR-3. Material and Methods: This cross-sectional study was performed on 52 formalin fixed and paraffin embedded blocks of oral lichen planus (pathological diagnosis based on Modified WHO criteria), comprising 25 of erosive and 27 of reticular type, along with 60 samples of normal mucosa (with minimal inflammation from clinical and histopathological aspects) obtained at crown lengthening surgery. Four micron sections were cut from paraffin blocks and stained with H and E for confirmation of diagnosis and by immunohistochemistry with primary antibodies against VEGFR-3. Read More

    Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus.
    J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
    Unilateral lichen planus (LP) is a rare clinical variant of LP. The etiology of unilateral LP has not been clarified, although various causes have been reported because of the characteristic distribution. We focused on the contribution of metal allergy and sweating in the development of unilateral LP in this case. Read More

    Lichen planus secondary to rabies vaccination.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
    Lichen planus (LP) is a papulosquamous disease withdistinctive clinical manifestations. The etiology of LPremains unknown. Recently, numerous cases of LPdeveloping after hepatitis B, influenza, and combinedDTaP-IPV-MMR vaccine have been described. Read More

    Lichen planus of the eyelids: a case report and review of the literature.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Department of Dermatology, Baylor College of Medicine, Houston, Texas.
    Lichen planus (LP) of the eyelid is an under-reportedmanifestation of a common inflammatory condition.To the best of our knowledge fewer than 20 cases ofeyelid LP have been described in the English literature.We report a case of a 29-year-old woman whopresented with 3-month history of bilateral eyelidpruritic violaceous papules and similar lesions on herchest and lower extremity. Read More

    A case of chilblain lupus erythematosus with lupus erythematosus/lichen planus overlap syndrome.
    J Eur Acad Dermatol Venereol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Chilblain lupus erythematosus (CHLE) is an acral erythema with cutaneous lesion of lupus erythematosus (LE) that is exacerbated during the winter (1). LE/lichen planus (LP) overlap syndrome is a rare cutaneous disorder characterized by mixed histological features of LE and LP at the same lesion (2). Although both CHLE and LE/LP overlap syndrome are immune mediated diseases (3), there is no indication that the same lymphocyte subset induces two distinct cutaneous lesions. Read More

    Immunopathogenic Oral Diseases: 
An Overview Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017 Mar 20. Epub 2017 Mar 20.
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Subgingival Microbiota in Caucasian Patients With Desquamative Gingivitis: A Cross-Sectional Study.
    J Periodontol 2017 Mar 17:1-14. Epub 2017 Mar 17.
    Department of Surgical Sciences, CIR - Dental School, University of Turin, Turin, Italy.
    Background: The presence of epithelial desquamation, erythema, and erosions on the gingival tissue is usually described in literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatological disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study was to investigate the prevalence of 11 periodonto-pathogenic microorganisms in DG cases and to compare it with microbiologic status of individuals affected by plaque-induced gingivitis (GI). Read More

    Coexistence of nail lichen planus and lichen planus pigmentosus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):20-22
    Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
    We describe a fifty-six-year old, Afro-descendent female patient showing dystrophy of her twenty nails and hyperchromic, asymptomatic macule on her face. Histopathological examination of the macule showed vacuolization of the basal layer, melanophages in the superficial dermis and lymphoplasmocytic inflammatory infiltrate. Nail biopsy revealed orthokeratotic hyperkeratosis and lichenoid inflammatory infiltrate. Read More

    Association between polymorphisms in interleukins and oral lichen planus: A meta-analysis.
    Medicine (Baltimore) 2017 Mar;96(11):e6314
    Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
    Background: More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene polymorphisms with the OLP risk. Read More

    Multiple erosive lichen planus preceded by solitary lichen planus after combination therapy with nivolumab and radiation.
    J Eur Acad Dermatol Venereol 2017 Mar 11. Epub 2017 Mar 11.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Erosive lichen planus (ELP) is a rare type of LP, which is a T cell-mediated chronic inflammatory disease that develops in the skin and mucosa (1). ELP differs from common solitary LP in that it is accompanied by pain and erosive changes in the lesions (1). Nivolumab is a monoclonal antibody to the immune check point molecule programmed death 1 (PD-1). Read More

    Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue.
    J Oral Pathol Med 2017 Mar 10. Epub 2017 Mar 10.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, 2-1-1 Nishitokuta Yahaba Shiwa-gun, Iwate, 028-3694, Japan.
    Background: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Read More

    A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.
    Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1070. Epub 2016 Dec 23.
    Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
    Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Read More

    Free palatal mucosal graft for treatment of erosive oral lichen planus.
    J Formos Med Assoc 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:

    Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus.
    PLoS One 2017 9;12(3):e0173017. Epub 2017 Mar 9.
    Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
    Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammation. Read More

    Gene expression of miRNA-138 and cyclin D1 in oral lichen planus.
    Clin Oral Investig 2017 Mar 8. Epub 2017 Mar 8.
    Department of Medical Biochemistry& Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt.
    Objectives: This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis.

    Methods: Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression. Read More

    Polydactylous Transverse Erythronychia: Report of a Patient with Multiple Horizontal Red Bands Affecting the Fingernails.
    Dermatol Ther (Heidelb) 2017 Mar 4. Epub 2017 Mar 4.
    Department of Dermatology, University of California San Diego, San Diego, CA, USA.
    Introduction: Redness of the nail plate-erythronychia-is a common condition involving one or multiple digits. It may affect the entire nail or present as longitudinal red bands that extend from the proximal nail fold to the distal tip of the nail plate. Rarely, red bands may traverse the nail bed horizontally. Read More

    Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing.
    Oncol Rep 2017 Apr 2;37(4):2355-2365. Epub 2017 Mar 2.
    Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
    Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the differently expressed genes (DEGs) in OLP vs. Read More

    Vulvovaginal Issues in Mature Women.
    Mayo Clin Proc 2017 Mar;92(3):449-454
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    Mature women often present with symptomatic vulvovaginal atrophy and vulvar dermatoses, causing noncoital pain, dyspareunia, and sexual changes. Diagnosis of these conditions can be challenging, and long-term management is required to decrease morbidity and enhance quality of life. Vaginal estrogen therapies remain safe and effective for treating symptomatic vulvovaginal atrophy. Read More

    [Frontal fibrosing alopecia: A prospective study of 20 cases].
    Ann Dermatol Venereol 2017 Feb 28. Epub 2017 Feb 28.
    Centre d'anatomopathologie Hassane, Rabat, Maroc.
    Background: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment.

    Patients And Methods: This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco. Read More

    Cutaneous side-effects of biologics in immune-mediated disorders: A histopathological perspective.
    J Dermatol 2017 Mar;44(3):243-250
    Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.
    Advances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side-effects, including cutaneous, have emerged. Many times a clear-cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. Read More

    Oral lichen planus in childhood: a case series.
    Int J Dermatol 2017 Mar 3. Epub 2017 Mar 3.
    Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.
    Background: Although the exact incidence of pediatric oral lichen planus (OLP) is unknown, the oral mucosa seems to be less commonly involved, and the clinical presentation is often atypical. The aim of the study is to present a case series of OLP in childhood.

    Methods: From our database, we retrospectively selected and analyzed the clinical data of OLP patients under the age of 18 where the diagnosis had been confirmed by histopathological analysis. Read More

    Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease.
    PLoS One 2017 2;12(3):e0172821. Epub 2017 Mar 2.
    University College London, UCL Eastman Dental Institute, London, United Kingdom.
    The IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 play a key role in many inflammatory conditions, particularly those mediated by T cells. Therefore, the production of these chemokines in peripheral tissues could be instrumental in the pathophysiology of tissue-specific immunological diseases such as oral lichen planus (OLP). In the present study, we assessed the production of keratinocyte-derived CXCL9/10/11 under basal and inflammatory conditions and investigated whether these chemokines were involved in the pathogenesis of OLP. Read More

    Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era.
    J Eur Acad Dermatol Venereol 2017 Mar 2. Epub 2017 Mar 2.
    Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY.
    New all-oral direct acting antivirals (DAA) have changed the hepatitis C virus (HCV) treatment landscape. Given that dermatologists frequently encounter HCV-infected patients, knowledge of the current treatment options and their utility in treating HCV-associated dermatologic disorders is important. In addition to highlighting the new treatment options, we review four classically HCV-associated dermatologic disorders - mixed cryoglobulinemia (MC), lichen planus (LP), porphyria cutanea tarda (PCT), and necrolytic acral erythema (NAE) - and examine the role for all-oral direct acting antiviral (DAA) regimens in their treatment. Read More

    Identification of potential therapeutic target genes, key miRNAs and mechanisms in oral lichen planus by bioinformatics analysis.
    Arch Oral Biol 2017 Feb 12;78:122-128. Epub 2017 Feb 12.
    Department of Reconstruction Surgery, Dalian Hospital of Stomatology, No. 935 Changjiang Rd, Shahekou District, Dalian, Liaoning, 116021, China. Electronic address:
    The study aimed to identify the potential target genes and key miRNAs as well as to explore the underlying mechanisms in the pathogenesis of oral lichen planus (OLP) by bioinformatics analysis. The microarray data of GSE38617 were downloaded from Gene Expression Omnibus (GEO) database. A total of 7 OLP and 7 normal samples were used to identify the differentially expressed genes (DEGs) and miRNAs. Read More

    Frontal Fibrosing Alopecia Coexisting with Lupus Erythematosus: Poor Response to Hydroxychloroquine.
    Skin Appendage Disord 2017 Jan 12;2(3-4):162-165. Epub 2016 Nov 12.
    Dermatology Clinic, Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil.
    Lupus erythematosus, especially the discoid form, and lichen planopilaris may be associated and can occur in different topographies (coexistence) or in the same lesion (lupus eythematosus/lichen planus overlap syndrome). Frontal fibrosing alopecia is considered a variant form of lichen planopilaris and is characterized by frontotemporal hairline and eyebrow involvement. Of the association with lupus erythematosus we have only a few descriptions. Read More

    Experimental Study on 1,25(OH)2 D3 Amelioration of Oral Lichen Planus through Regulating NF-κB Signaling Pathway.
    Oral Dis 2017 Feb 23. Epub 2017 Feb 23.
    Department of Stomatology of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
    Objective: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it.

    Methods: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR. Read More

    Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus.
    Clin Chim Acta 2017 Feb 16;468:46-50. Epub 2017 Feb 16.
    School of Stomatology, Harbin Medical University, Harbin 151000, PR China.
    Background: Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    A Case of Lichen Planus Pigmentosus with Facial Dyspigmentation Responsive to Combination Therapy with Chemical Peels and Topical Retinoids.
    J Clin Aesthet Dermatol 2016 Nov 1;9(11):44-50. Epub 2016 Nov 1.
    Residency Program Director, New York College of Osteopathic Medicine of New York Institute of Technology, Department of Dermatology, St. Barnabas Hospital, Bronx, New York.
    Lichen planus pigmentosus is a photodistributed dyschromia of unknown etiology described clinically as hyperpigmented gray-blue or brown-black macules or patches in a photodistributed pattern. Although there has been some debate, lichen planus pigmentosus is considered by many to be a separate diagnostic entity from ashy dermatosis or erythema dyschromicum perstans, which shares similar characteristics. Various treatment strategies have been applied to help resolve or improve the appearance of lichen planus pigmentosus lesions; however, an optimal treatment method is yet to be elucidated. Read More

    Lichen planus hypertrophicus of the vulva - a rare entity.
    Int J STD AIDS 2017 Jan 1:956462417695052. Epub 2017 Jan 1.
    Department of Dermatology, St John's Medical College, Bangalore, India.
    Vulvovaginal lichen planus is a type of chronic inflammatory dermatosis of the vulva, usually seen as a part of widespread lichen planus. The common clinical types of vulval lichen planus include papulosquamous, erosive and pigmented types. Hypertrophic lichen planus of the vulva is a rare entity. Read More

    [Analysis of type C behavior in patients with oral lichen planus].
    Beijing Da Xue Xue Bao 2017 Feb;49(1):120-124
    Department of Oral Medicine,Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To assess type C behavior in patients with oral lichen planus (OLP) in order to provide basis for clinical prevention, treatment and psychological intervention of OLP.

    Methods: Type C behavior scale was used on 85 OLP patients and 85 control patients, who were in accordance with the inclusion criteria, in order to investigate their type C behavior. The scale included 9 items: anxiety, depression, anger, anger toward inside (anger-in), anger toward outside (anger-out), reasoning, domination, optimism, and social support. Read More

    Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus.
    Oral Dis 2017 Feb 15. Epub 2017 Feb 15.
    School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
    Objective: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control.

    Subjects And Methods: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. Read More

    Investigating the level of salivary endothelin-1 in premalignant and malignant lesions.
    Spec Care Dentist 2017 Feb 15. Epub 2017 Feb 15.
    Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
    Purpose: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions.

    Materials And Methods: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. Read More

    Salivary oxidative status in patients with oral lichen planus.
    J Physiol Pharmacol 2016 Dec;67(6):885-894
    Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.
    Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. Read More

    Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.
    Arch Oral Biol 2017 Feb 6;78:13-19. Epub 2017 Feb 6.
    Research Group of Chronic Inflammatory Oral Diseases and Systemic Diseases Associated with Oral Health, Khon Kaen University, Khon Kaen, Thailand; Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand. Electronic address:
    Objective: The existence of extra-pineal melatonin has been observed in various tissues. No prior studies of melatonin in human oral mucosal tissue under the condition of chronic inflammation have been reported. The aim of this study was to investigate the presence of melatonin in oral mucosal tissue of patients with oral lichen planus (OLP) which was considered as a chronic inflammatory immune-mediated disease causing oral mucosal damage and ulcerations. Read More

    Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?
    J Oral Pathol Med 2017 Feb 10. Epub 2017 Feb 10.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunofluorescent microscopy are essential for definitive diagnosis. Read More

    Most Frequent Oral Lesions in Patients with Type 2 Diabetes Mellitus.
    J Contemp Dent Pract 2017 Feb 1;18(2):107-111. Epub 2017 Feb 1.
    Department of Dentistry, Federal University of Sergipe Lagarto, Sergipe, Brazil.
    Aim: Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease.

    Materials And Methods: This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF. Read More

    Topical tacrolimus, triamcinolone acetonide and placebo in oral lichen planus: A pilot randomized controlled trial.
    Oral Dis 2017 Feb 6. Epub 2017 Feb 6.
    Institute of Dentistry, University of Oulu, Finland.
    Objective: To carry out a double-blind RCT to compare the effectiveness of topical tacrolimus (TAC), triamcinolone acetonide (TRI) and placebo (PLA) in symptomatic OLP.

    Subjects And Methods: A clinical score (CS, range 0-130) was developed to measure the clinical signs and symptoms of OLP. Twenty-seven OLP patients with a CS of ≥ 20 were randomly allocated to receive 0. Read More

    Squamous Cell Carcinoma Versus Hypertrophic Lichen Planus; a Difficult Differential Diagnosis of Great Significance in Approach to Treatment.
    Dermatol Surg 2017 Feb;43(2):297-299
    Department of Dermatology, University of Texas Health Sciences Center Houston, Houston, TexasRabkin Dermatopathology Laboratory, P.C., Tarentum, PennsylvaniaDermatology Associates, Pasadena, TexasDepartment of Dermatology, University of Texas Health Sciences Center Houston, Houston, Texas.

    Comparison of B-Cell Activating Factor Expression in Neutrophils in Patients with Potentially Malignant Disorders and Patients with Cancer in the Same Site.
    Clin Lab 2016 Aug;62(8):1507-1514
    Background: B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC), suggesting a tumor-promoting activity of those cells. Taking into consideration that numerous OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs), involving e. Read More

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