9,465 results match your criteria Lichen Planus


A successful combination therapy of tacrolimus, hydroxychloroquine and picosecond laser for lichen planus pigmentosus.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/ajd.13060DOI Listing
April 2019
2 Reads

Esophageal Stenosis in a Patient with Lichen Planus.

Case Rep Gastroenterol 2019 Jan-Apr;13(1):134-139. Epub 2019 Mar 7.

J&J MEDICI" Polyclinic for Internal Medicine, Split, Croatia.

Lichen planus is a chronic, idiopathic disorder which usually affects skin and mucosal surfaces. While oral mucosa is frequently involved, esophageal localization is uncommon, and it usually manifests with dysphagia. It has also been associated with squamous cell carcinoma. Read More

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http://dx.doi.org/10.1159/000498907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465741PMC

Expression and biological functions of the CCL5-CCR5 axis in oral lichen planus.

Exp Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder with T cell-mediated immunological pathogenesis. C-C motif chemokine ligand 5 (CCL5) and its receptor C-C motif chemokine receptor 5 (CCR5) play important roles in the activation and recruitment of T cells. This study sought to explore the expression and biological functions of the CCL5-CCR5 axis in OLP. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13946
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http://dx.doi.org/10.1111/exd.13946DOI Listing
April 2019
1 Read

Novel Oral Lichen Planus Symptom Severity Measure for assessing patients' daily symptom experience.

Oral Dis 2019 Apr 21. Epub 2019 Apr 21.

AFYX Therapeutics, formerly known as Dermtreat, 2300, Copenhagen S, Denmark.

Objective: A novel Oral Lichen Planus Symptom Severity Measure was developed as a clinical outcome assessment of the daily symptom experience of patients with oral lichen planus.

Methods: A literature review and expert input were followed by open-ended concept elicitation interviews with 17 adults with oral lichen planus in the US and Ireland. Item content was generated and the interviews continued until input saturation was reached. Read More

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http://dx.doi.org/10.1111/odi.13109DOI Listing

Clinical epidemiology and treatment of lichen planus: a retrospective review of two tertiary care centers.

J Am Acad Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, NY; NYU School of Medicine, 550 First Avenue, New York, NY 10016.

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http://dx.doi.org/10.1016/j.jaad.2019.04.027DOI Listing

Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin.

Int J Womens Dermatol 2019 Jun 16;5(2):100-104. Epub 2018 Nov 16.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lichen planus (LP) is a chronic inflammatory disease of the skin. Currently, noninvasive techniques are used to evaluate biophysical properties of the skin in vivo.

Objective: In this study, we aimed to evaluate skin biophysical properties in patients with LP and make a comparison between involved and uninvolved skin to provide a better understanding of the pathogenesis of LP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183004
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http://dx.doi.org/10.1016/j.ijwd.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451735PMC
June 2019
1 Read

Psychological disorders and quality of life in oral lichen planus patients and a control group.

Oral Dis 2019 Apr 16. Epub 2019 Apr 16.

Oral Medicine, Oral Surgery and Implantology Unit. Faculty of Medicine and Dentistry., Santiago de Compostela, Spain.

Objectives: oral lichen planus (OLP) is a common disease whose aetiopathogenesis is linked to psychological disorders. This study aims to determine the influence of anxiety and depression in OLP patients, define the perception of quality of life in these patients and check for potential differences between atrophic/ ulcerative and reticular lesions.

Material And Methods: a group of 48 OLP patients and a control group of 40 patients were selected. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13106
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http://dx.doi.org/10.1111/odi.13106DOI Listing
April 2019
1 Read

Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety.

Clin Oral Investig 2019 Apr 15. Epub 2019 Apr 15.

Department of Stomatology, Public Oral Health and Forensic Dentistry, Division of Oral Diagnosis, School of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.

Objectives: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are chronic inflammatory diseases whose symptoms can impair patient's quality of life (QoL). Psychological factors seem to play an important role in these diseases. This study aimed to determine the impact of oral health and anxiety levels on the QoL of patients with OLP and OLL. Read More

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http://link.springer.com/10.1007/s00784-019-02892-2
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http://dx.doi.org/10.1007/s00784-019-02892-2DOI Listing
April 2019
2 Reads

Generalized Licen Planus Treated With Narrowband UV-B Phototherapy: Results From 10 Patients and a Review of the Literature.

Actas Dermosifiliogr 2019 Apr 13. Epub 2019 Apr 13.

Servicio de Dermatología, Hospital Universitario Sanitas La Zarzuela, Universidad Francisco de Vitoria, Madrid, España.

Generalized lichen planus can be difficult to treat. One alternative for patients who do not respond to common topical and systemic treatments, such as corticosteroids and oral antihistamines, is phototherapy. Narrowband UV-B phototherapy offers several advantages and is currently the main treatment modality. Read More

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http://dx.doi.org/10.1016/j.ad.2018.01.015DOI Listing

Zinc Therapy in Treatment of Symptomatic Oral Lichen Planus.

Indian Dermatol Online J 2019 Mar-Apr;10(2):174-177

Department of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.

Lichen planus is a chronic inflammatory disease, which involves skin, mucous membrane, and nails. Prevalence of oral lichen planus varies between 0.5% and 2. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_230_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434769PMC
April 2019
1 Read

Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders.

Indian Dermatol Online J 2019 Mar-Apr;10(2):115-124

Department of Dermatology, Aesthetic Surgery and Intervention Dermatology, AURA Skin Institute, Chandigarh, India.

Background: Diet has an important role to play in the well-being of human body.

Aims: The study intends to establish the "hypothesis of conscious, selective, and self-destruction i.e. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_123_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747PMC
April 2019
5 Reads

Coexistence of Linear and Inversus Variants of Lichen Planus Pigmentosus: A Rare Occurrence.

Indian J Dermatol 2019 Mar-Apr;64(2):152-154

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Lichen planus pigmentosus (LPP) is a rare disorder affecting primarily the people with ethnic skin. It results in hyperpigmentation of sun-exposed sites along with the involvement of flexures. In accordance with clinical patterns, different variants such as diffuse, blotchy, reticulate, and perifollicular have been described. Read More

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http://dx.doi.org/10.4103/ijd.IJD_599_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440191PMC

Dermoscopy of lichen planus: Vascular and Wickham striae variations in the skin of colour.

Australas J Dermatol 2019 Apr 14. Epub 2019 Apr 14.

Department of Dermatology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1111/ajd.13052DOI Listing

Direct Immunofluorescence Studies in Lichen Planus.

Turk Patoloji Derg 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Bharati Vidyapeeth (deemed to be university) Medical College and Hospital, SANGLI, INDIA.

Objective: Lichen planus is a common, usually intensely pruritic, symmetrical, papulosquamous dermatosis. Direct immunofluorescence studies in patients with lichen planus shows deposition of multiple immunoglobulins and fibrin at the dermoepidermal junction and in the colloid bodies.

Material And Method: Histopathological features were analysed in 100 cases of lichen planus which were sent for routine histology. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01455DOI Listing

Postherpetic hypohidrosis-related isotopic response associated with lichen planus and lichen amyloidosis.

Eur J Dermatol 2019 Apr 12. Epub 2019 Apr 12.

Department of dermatology, Kawasaki Medical School, Kurashiki.

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http://dx.doi.org/10.1684/ejd.2019.3516DOI Listing

Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland.

Human β-defensin 2 (hBD-2) is a potent antimicrobial peptide that participates in defense against invading bacteria. We recently showed that bacterial components and histamine, through histamine H4 receptor (H4R), are involved in the pathogenesis of the potentially malignant lesion, oral lichen planus (OLP). However, the underlying mechanisms remain unknown. Read More

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http://dx.doi.org/10.3390/ijms20071780DOI Listing
April 2019
1 Read

Down-regulation of miRNA-27b-3p suppresses keratinocytes apoptosis in oral lichen planus.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Oral lichen planus (OLP) is considered a precancerous lesion with no known cure. Recent studies reported that abnormal regulation of apoptosis was involved in the pathogenesis of OLP. Next generation sequencing was used to screen the candidate microRNAs and genes in biopsies from patients with OLP and healthy mucosa. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14324
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http://dx.doi.org/10.1111/jcmm.14324DOI Listing
April 2019
2 Reads

Proposition of a comprehensive score to assess the disease severity and activity of cutaneous lichen planus.

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/ijd.14459DOI Listing
April 2019
1.227 Impact Factor

Editorial expression of concern: The measurement of serum TNF-α levels in patients with lichen planus

Authors:

Acta Dermatovenerol Alp Pannonica Adriat 2019 03;28(1):51

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http://dx.doi.org/10.15570/actaapa.2019.13DOI Listing

Insight into verruciform xanthoma with oral submucous fibrosis: Case report and review of literature.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):43-48

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Dilsukhnagar, Hyderabad, Telangana, India.

Verruciform xanthoma (VX) is a rare benign mucocutaneous verrucopapillary lesion, which mainly involves masticatory mucosa and gingiva. Clinically, it presents as a solitary, sessile or pedunculated, white- or yellow-white-colored growth with a pebbled surface, hence often misdiagnosed as papilloma. The hallmark of histological diagnosis is the presence of foam cells or xanthoma cells confined to the connective tissue papillae. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_210_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421923PMC
February 2019
5 Reads

Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus.

PLoS One 2019 9;14(4):e0215055. Epub 2019 Apr 9.

Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany.

Head and neck squamous cell carcinoma (HNSCC) affects about 700.000 individuals per year worldwide with oral squamous cell carcinoma (OSCC) as a major subcategory. Despite a comprehensive treatment concept including surgery, radiation, and chemotherapy the 5-year survival rate is still only about 50 percent. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215055PLOS

Exaggerated epidermal pigmentation in acquired dermal macular hyperpigmentation: An important finding.

Clin Exp Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

We congratulate the authors Nakazato and Anan for an interesting report demonstrating Fontana Masson stained epidermal melanin granules in a patient having lichen planus pigmentosus inversus. As authors of 2 large series on acquired dermal macular hyperpigmentation (ADMH), in both of which we reported the presence of epidermal melanization extending to epidermal layers beyond the basal layer, we suggest that this finding has important pathogenetic and therapeutic implications. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/ced.13978DOI Listing

Assessing the correlation between trichoscopic features in lichen planopilaris and lichen planopilaris activity index.

Australas J Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background/objectives: Videodermoscopy is a valuable tool for the diagnosis of cicatricial alopecias such as lichen planopilaris. Lichen planopilaris activity index is used for evaluating lichen planopilaris severity. Our aim was to examine the utility of videodermoscopy in the assessment of lichen planopilaris severity. Read More

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http://dx.doi.org/10.1111/ajd.13022DOI Listing
April 2019
2 Reads

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

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http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

Effects of oral healthcare motivation in patients with gingival oral lichen planus: A randomized controlled trial.

Oral Dis 2019 Apr 4. Epub 2019 Apr 4.

Dipartimento di Medicina e Chirurgia, Centro Universitario di Odontoiatria, Università di Parma, Parma, Italy.

Objectives: The role of dental plaque in gingival lesions caused by oral lichen planus has not been fully defined. The aim of this clinical trial was to evaluate the effects of oral healthcare motivation on clinical variables in patients with gingival oral lichen planus.

Material And Methods: Oral lichen planus patients with symptomatic gingival lesions were randomized in control and intervention groups. Read More

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http://dx.doi.org/10.1111/odi.13104DOI Listing
April 2019
1 Read

Hypopigmented Macules as Manifestation of Lichen Planus and Lichen Planopilaris.

Am J Dermatopathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Lichen planus (LP) is an idiopathic inflammatory disease of the skin, hair, nails, and mucous membranes. Classic cutaneous LP is characterized by violaceous flat-topped papules that typically favor the extremities. LP on the scalp, otherwise known as lichen planopilaris, classically presents with scarring alopecia, perifollicular erythema and follicular prominence. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9816
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http://dx.doi.org/10.1097/DAD.0000000000001389DOI Listing
March 2019
7 Reads

Mucosal Lichen Planus Mimicking Mucosal Lesions in Stevens-Johnson Syndrome after Nivolumab Therapy.

Acta Derm Venereol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Nara Medical University, Nara 634-8522, Japan.

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http://dx.doi.org/10.2340/00015555-3185DOI Listing
April 2019
3 Reads

Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition.

Photochem Photobiol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, Dermatology Unit, University of Modena & Reggio Emilia, Modena, Italy.

In vivo reflectance confocal microscopy (RCM) is a noninvasive high-resolution skin imaging tool that has become an important adjunct to clinical exam, dermoscopy and histopathology assessment, in the diagnosis and management of pigmented macules of the face. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging and RCM improves the diagnostic accuracy in the differential diagnosis of LM with other macules of the face such as solar lentigo (SL), pigmented actinic keratosis (PAK), seborrheic keratosis (SK) and lichen planus-like keratosis (LPLK). Here we review the state-of-the-art of RCM morphologic descriptors, standardized terminology, and diagnostic algorithms for the RCM assessment of pigmented macules of the face including melanocytic, and nonmelanocytic lesions. Read More

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http://dx.doi.org/10.1039/c8pp00525gDOI Listing
April 2019
2 Reads

Changing epidemiology of HCV infection in patients with oral lichen planus in north-west Italy.

Oral Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1111/odi.13099DOI Listing

The effects of sustained virological response to direct-acting anti-viral therapy on the risk of extrahepatic manifestations of hepatitis C infection.

Aliment Pharmacol Ther 2019 Apr 1. Epub 2019 Apr 1.

Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E DeBakey VA Medical Center, Houston, Texas.

Background: Direct-acting anti-viral (DAA) therapy may have a beneficial role in extrahepatic manifestations of hepatitis C virus (HCV) infection. However, the available data are limited.

Aim: To examine the effects of DAA treatment on the risk of several extrahepatic manifestations of HCV. Read More

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http://dx.doi.org/10.1111/apt.15240DOI Listing
April 2019
3 Reads

Relationship of infiltrating intraepithelial T lymphocytes in the diagnosis of oral lichen planus versus oral epithelial dysplasia: a pilot study.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 13. Epub 2019 Feb 13.

Kaneda Family Distinguished Associate Professor, Oral and Maxillofacial Pathology, Department of Diagnostic Sciences, University of North Carolina at Chapel Hill, School of Dentistry, 101 Manning Drive, Chapel Hill, NC, USA.

Objective: The aim of this study was to identify the type and distribution of CD4+ and CD8+ T lymphocytes in oral mucosal specimens to potentially distinguish between underlying alterations or patterns in oral epithelial dysplasia and oral lichen planus.

Study Design: This pilot study included 10 archived tissue samples that were received at the University of North Carolina Oral and Maxillofacial Pathology Laboratory and were diagnosed as oral lichen planus and moderate to severe epithelial dysplasia. Dual staining with CD4 and CD8 antibodies was carried out on each case. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.02.004DOI Listing
February 2019
1 Read

Treatment effectiveness of levamisole plus prednisolone on oral lichen planus patients with emphasis on levamisole-induced agranulocytosis or pancytopenia.

J Formos Med Assoc 2019 Mar 25. Epub 2019 Mar 25.

Oral Pathology and Family Dentistry Section, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background/purpose: Physicians' and dentists' knowledge of levamisole-induced agranulocytosis or pancytopenia remains incomplete. This study aimed to evaluate the treatment effectiveness of levamisole plus prednisolone on oral lichen planus (OLP) patients with emphasis on levamisole-induced hematological changes.

Methods: Ninety patients with erosive OLP were given 120 mg/day new levamisole (Levazol) and 15 mg/day prednisolone for three consecutive days each week. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.007DOI Listing
March 2019
3 Reads

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.

Eur J Cancer Prev 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine, University of Tennessee Health Science Centre, Memphis, Tennessee, USA.

Around 300 000 patients are estimated to have oral cancer worldwide annually, and the incidence is higher in South Asian countries. In 2005, at the Congress of WHO, the term potentially malignant disorder (PMD)/lesion was suggested as a replacement for premalignant oral lesions and conditions. PMDs are those lesions of the oral mucosa that are at an increased risk of malignant transformation compared with the healthy mucosa. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000510DOI Listing

Lichen with triple involvement: cutaneous, mucous and phanerian.

Pan Afr Med J 2018;31:12. Epub 2018 Sep 4.

Dermatology Department, Avicenna Hospital, Ibn Sina University Hospital, Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2018.31.12.16510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430939PMC

Differential diagnosis of leukoplakia versus lichen planus of the oral mucosa based on digital texture analysis in intraoral photography.

Adv Clin Exp Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Maxillofacial Surgery, Faculty of Military Medicine, Medical University of Lodz, Poland.

Background: A noninvasive, accurate and quick diagnosis is very important to general practitioners and specialists who care for the health of patients' oral cavity mucosa. The main enemies are precancerous lesions: leukoplakia and lichen planus (LP).

Objectives: The aim of this study was to attempt to formulate a differential diagnosis for leukoplakia vs LP in the oral mucosa based on digital texture analysis in intraoral macrophotography. Read More

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http://dx.doi.org/10.17219/acem/104524DOI Listing

Brimonidine-induced unilateral ocular lichen planus: a case report.

Arq Bras Oftalmol 2019 Mar 25. Epub 2019 Mar 25.

Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.

This report was written to describe a case of unilateral brimonidine-induced conjunctival lichen planus. Because the ophthalmic examination indicated chronic conjunctivitis or drug-induced pseudopemphigoid, the patient underwent thorough ophthalmic and systemic examinations, as well as conjunctival biopsy and direct immunofluorescence studies. A 71-year-old woman with unilateral left eye findings of chronic conjunctivitis was referred to our Ophthalmology Department. Read More

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http://dx.doi.org/10.5935/0004-2749.20190047DOI Listing

Implications on pathogenesis and risk of oral lichen planus neoplastic transformation: an ex-vivo retrospective immunohistochemical study.

Histol Histopathol 2019 Mar 25:18104. Epub 2019 Mar 25.

Pathology Unit, Ospedale "Sant'Andrea", DiMeT, UPO, Vercelli, Italy.

Aims: to evaluate OPN, MCM7, Ki-67, p53, Bcl-2 and 53BP1 presence, together with the abnormal adaptive CD4 and CD8 T-cell response markers expression in a series of oral lichen planus (OLP) affected patients and assess their combined contribution for a more objective disease classification.

Methods And Results: In this ex-vivo retrospective analysis, biopsy specimens from 28 adults with a clinical diagnosis of OLP at different progression degree (16 reticular, 2 plaque-like, 1 erosive and 9 mixed type) were collected. Sections were immunohistochemically investigated for the proinflammatory cytokine osteopontin (OPN), alpha-beta CD4 and CD8 positive T cells, DNA replication licensing factor (MCM7), proliferating cell marker (Ki-67), apoptotic and tumor antigen (p53), apoptosis modulator (Bcl-2) and cellular response regulator to double-strand breaks tumor suppressor p53-binding protein 1 expression. Read More

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http://dx.doi.org/10.14670/HH-18-104DOI Listing
March 2019
1 Read

Rate of actual metal allergy prior to dental treatment in subjects complaining of possible metal allergy.

Asian Pac J Allergy Immunol 2019 Mar 24. Epub 2019 Mar 24.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Dental treatment for patients with self-reported metal allergy or concern about the possibility of having such an allergy is often difficult; such patients often undergo dermatological consultations for metal patch test (PT).

Objective: This study compared PT results for metal allergens and the clinical relevance of this among patients visiting Fukuoka Dental College Hospital.

Methods: We performed PT with metal allergens on patients with oral mucosa- or skin-related symptoms, or those concerned about adverse events associated with upcoming dental treatment. Read More

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http://dx.doi.org/10.12932/AP-241018-0425DOI Listing

Topical calcineurin inhibitors in the treatment of oral lichen planus: a systematic review and meta-analysis.

Br J Dermatol 2019 Mar 22. Epub 2019 Mar 22.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.

Background: TCS (topical corticosteroids) is the first-line drug in the treatment of oral lichen planus (OLP). However, the value of topical calcineurin inhibitors (TCI) including tacrolimus, pimecrolimus and cyclosporine for OLP is still controversial.

Objectives: The article was carried out to compare the efficacy and safety of TCI with TCS for OLP. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17898
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http://dx.doi.org/10.1111/bjd.17898DOI Listing
March 2019
13 Reads

Time trend in the prevalence of oral lichen planus based on Taiwanese National Health Insurance Research Database 1996-2013.

J Dent Sci 2018 Sep 13;13(3):274-280. Epub 2018 Jul 13.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Background/purpose: Oral lichen planus (OLP) is a common chronic inflammatory disease characterized by a T cell-mediated immune response against epithelial cells. The epidemiological survey of OLP in Taiwanese population was scarce. In this study, we investigated the time trend of prevalence stratified by gender, age, urbanization, and income of OLP based on National Health Insurance Research Database (NHIRD). Read More

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http://dx.doi.org/10.1016/j.jds.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388843PMC
September 2018
1 Read

Frontal fibrosing alopecia demographics: a survey of 29 patients.

Cutis 2018 Feb;102(2):E16-E22

Division of Dermatology, Washington University, USA.

Frontal fibrosing alopecia (FFA) is a form of scarring alopecia whose diagnosis is increasing globally. Although its etiology is unknown, FFA is thought to be a clinical subset of lichen planopilaris (LPP) that primarily affects postmenopausal women. Patients diagnosed with FFA between January 2006 and December 2013 at clinics of the Washington University Division of Dermatology (St. Read More

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February 2018
11 Reads

Clinical and epidemiological profile of patients attended in a vulvar clinic of the dermatology outpatient unit of a tertiary hospital during a 4-year period.

Int J Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil.

Background: Vulvar complaints are among the most frequent causes for a woman to visit a healthcare provider. The diseases of this area of the body may be a challenge to diagnose. In this study, we assess epidemiologic and clinical data of patients in an outpatient vulvar clinic in the dermatology department of a tertiary hospital. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14442
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http://dx.doi.org/10.1111/ijd.14442DOI Listing
March 2019
4 Reads

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature.

Curr Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. India.

Oral cancer (OC) is a serious and a growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in expected number of new cases in US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Read More

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http://www.eurekaselect.com/170833/article
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http://dx.doi.org/10.2174/1389450120666190319125734DOI Listing
March 2019
7 Reads

Oral Epithelial Dysplasia and Premalignancy.

Authors:
Sook-Bin Woo

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Harvard School of Dental Medicine, Boston, MA, USA.

Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years. Importantly, traumatic/frictional keratoses are often mistaken clinically for leukoplakia and it is important for the pathologist to recognize and report them as such. The features of OED have been well-described and other architectural features will be discussed here, in particular verrucous and papillary architecture, bulky epithelial proliferation and epithelial atrophy. Read More

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http://dx.doi.org/10.1007/s12105-019-01020-6DOI Listing
March 2019
2 Reads

Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, , Green Tea and Coffee Properties.

Biomolecules 2019 03 17;9(3). Epub 2019 Mar 17.

Food Safety Research Center (Salt), Semnan University of Medical Sciences, Semnan 35198-99951, Iran.

Oral mucosal lesions have many etiologies, including viral or bacterial infections, local trauma or irritation, systemic disorders, and even excessive alcohol and tobacco consumption. Folk knowledge on medicinal plants and phytochemicals in the treatment of oral mucosal lesions has gained special attention among the scientific community. Thus, this review aims to provide a brief overview on the traditional knowledge of plants in the treatment of oral mucosal lesions. Read More

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http://dx.doi.org/10.3390/biom9030106DOI Listing

Contact sensitization to hair colours in acquired dermal macular hyperpigmentation: results from a patch and photo-patch test study of 108 patients.

J Eur Acad Dermatol Venereol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis.

Objective: To establish contact sensitization to hair colours as an aetiological factor for ADMH.

Methods: Detailed clinical examination, skin biopsies, and patch and photo-patch testing with Indian standard series and patient's own cosmetic products were performed. Read More

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http://dx.doi.org/10.1111/jdv.15576DOI Listing
March 2019
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2.826 Impact Factor

Acquired Macular Pigmentation of Unknown Etiology.

J Clin Aesthet Dermatol 2019 Jan 1;12(1):38-46. Epub 2019 Jan 1.

Dr. Udompanich and Dr. Vachiramon are with the Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University in Bangkok, Thailand.

is a new umbrella term that encompasses a group of diseases that, while having similar clinical and histological features, their true entities are controversial, and a global consensus regarding these conditions is still lacking. The conditions comprised by the term are ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, and idiopathic eruptive macular pigmentation. In this review, we compare the clinical and histological features of these conditions that comprise aquired macular pimgentation of unknown etiology, as well as review their responses to treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405250PMC
January 2019
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Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review.

Cureus 2018 Dec 31;10(12):e3802. Epub 2018 Dec 31.

Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, IND.

Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in India and most other developing countries. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Hence, these patients warrant regular screening by oral health care professionals and proper monitoring for any dysplastic changes. Read More

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http://dx.doi.org/10.7759/cureus.3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402749PMC
December 2018
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Aggressive erosive lichen planus associated with hepatitis C responding to sofosbuvir/ledipasvir treatment.

Indian J Dermatol Venereol Leprol 2019 May-Jun;85(3):326-329

Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_225_18DOI Listing
March 2019
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