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    Experimental Study on 1,25(OH)2 D3 Amelioration of Oral Lichen Planus through Regulating NF-κB Signaling Pathway.
    Oral Dis 2017 Feb 23. Epub 2017 Feb 23.
    Department of Stomatology of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
    Objective: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it.

    Methods: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR. Read More

    Lichen Planus Like Lesions Caused by Thiacetazone.
    Indian J Dermatol Venereol Leprol 1979 Nov-Dec;45(6):455-458
    Thiacetazone has been used as a standard antituberculous drug in several countries. Side effect& which include various VM of skin eruptions have been observed in about 10% of patients taking thiacetazone. We are reporting two' cases of lichen planus-like lesions presumably due to thiacetazone. Read More

    Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus.
    Clin Chim Acta 2017 Feb 16;468:46-50. Epub 2017 Feb 16.
    School of Stomatology, Harbin Medical University, Harbin 151000, PR China.
    Background: Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment. Read More

    Paraneoplastic pemphigus associated with Castleman disease: Progression from mucous to mucocutaneous lesions with epitope-spreading phenomena.
    Br J Dermatol 2017 Feb 18. Epub 2017 Feb 18.
    Departments of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
    Paraneoplastic pemphigus (PNP) is a frequently fatal autoimmune blistering disease of the skin and mucous membranes.(1) PNP is commonly associated with malignant neoplasms or haematological disorders like Castleman disease (CD). The eruptions may resemble those seen in various other conditions such as lichen planus (LP), graft-versus-host disease, erythema multiforme (EM), bullous pemphigoid and pemphigus vulgaris (PV). Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    A Case of Lichen Planus Pigmentosus with Facial Dyspigmentation Responsive to Combination Therapy with Chemical Peels and Topical Retinoids.
    J Clin Aesthet Dermatol 2016 Nov 1;9(11):44-50. Epub 2016 Nov 1.
    Residency Program Director, New York College of Osteopathic Medicine of New York Institute of Technology, Department of Dermatology, St. Barnabas Hospital, Bronx, New York.
    Lichen planus pigmentosus is a photodistributed dyschromia of unknown etiology described clinically as hyperpigmented gray-blue or brown-black macules or patches in a photodistributed pattern. Although there has been some debate, lichen planus pigmentosus is considered by many to be a separate diagnostic entity from ashy dermatosis or erythema dyschromicum perstans, which shares similar characteristics. Various treatment strategies have been applied to help resolve or improve the appearance of lichen planus pigmentosus lesions; however, an optimal treatment method is yet to be elucidated. Read More

    Lichen planus hypertrophicus of the vulva - a rare entity.
    Int J STD AIDS 2017 Jan 1:956462417695052. Epub 2017 Jan 1.
    Department of Dermatology, St John's Medical College, Bangalore, India.
    Vulvovaginal lichen planus is a type of chronic inflammatory dermatosis of the vulva, usually seen as a part of widespread lichen planus. The common clinical types of vulval lichen planus include papulosquamous, erosive and pigmented types. Hypertrophic lichen planus of the vulva is a rare entity. Read More

    [Analysis of type C behavior in patients with oral lichen planus].
    Beijing Da Xue Xue Bao 2017 Feb;49(1):120-124
    Department of Oral Medicine,Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To assess type C behavior in patients with oral lichen planus (OLP) in order to provide basis for clinical prevention, treatment and psychological intervention of OLP.

    Methods: Type C behavior scale was used on 85 OLP patients and 85 control patients, who were in accordance with the inclusion criteria, in order to investigate their type C behavior. The scale included 9 items: anxiety, depression, anger, anger toward inside (anger-in), anger toward outside (anger-out), reasoning, domination, optimism, and social support. Read More

    Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus.
    Oral Dis 2017 Feb 15. Epub 2017 Feb 15.
    School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
    Objective: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control.

    Subjects And Methods: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. Read More

    Investigating the level of salivary endothelin-1 in premalignant and malignant lesions.
    Spec Care Dentist 2017 Feb 15. Epub 2017 Feb 15.
    Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
    Purpose: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions.

    Materials And Methods: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. Read More

    Salivary oxidative status in patients with oral lichen planus.
    J Physiol Pharmacol 2016 Dec;67(6):885-894
    Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.
    Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. Read More

    Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.
    Arch Oral Biol 2017 Feb 6;78:13-19. Epub 2017 Feb 6.
    Research Group of Chronic Inflammatory Oral Diseases and Systemic Diseases Associated with Oral Health, Khon Kaen University, Khon Kaen, Thailand; Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand. Electronic address:
    Objective: The existence of extra-pineal melatonin has been observed in various tissues. No prior studies of melatonin in human oral mucosal tissue under the condition of chronic inflammation have been reported. The aim of this study was to investigate the presence of melatonin in oral mucosal tissue of patients with oral lichen planus (OLP) which was considered as a chronic inflammatory immune-mediated disease causing oral mucosal damage and ulcerations. Read More

    Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?
    J Oral Pathol Med 2017 Feb 10. Epub 2017 Feb 10.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. Read More

    Most Frequent Oral Lesions in Patients with Type 2 Diabetes Mellitus.
    J Contemp Dent Pract 2017 Feb 1;18(2):107-111. Epub 2017 Feb 1.
    Department of Dentistry, Federal University of Sergipe Lagarto, Sergipe, Brazil.
    Aim: Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease.

    Materials And Methods: This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF. Read More

    Topical tacrolimus, triamcinolone acetonide and placebo in oral lichen planus: A pilot randomized controlled trial.
    Oral Dis 2017 Feb 6. Epub 2017 Feb 6.
    Institute of Dentistry, University of Oulu, Finland.
    Objective: To carry out a double-blind RCT to compare the effectiveness of topical tacrolimus (TAC), triamcinolone acetonide (TRI) and placebo (PLA) in symptomatic OLP.

    Subjects And Methods: A clinical score (CS, range 0-130) was developed to measure the clinical signs and symptoms of OLP. Twenty-seven OLP patients with a CS of ≥ 20 were randomly allocated to receive 0. Read More

    Squamous Cell Carcinoma Versus Hypertrophic Lichen Planus; a Difficult Differential Diagnosis of Great Significance in Approach to Treatment.
    Dermatol Surg 2017 Feb;43(2):297-299
    Department of Dermatology, University of Texas Health Sciences Center Houston, Houston, TexasRabkin Dermatopathology Laboratory, P.C., Tarentum, PennsylvaniaDermatology Associates, Pasadena, TexasDepartment of Dermatology, University of Texas Health Sciences Center Houston, Houston, Texas.

    Comparison of B-Cell Activating Factor Expression in Neutrophils in Patients with Potentially Malignant Disorders and Patients with Cancer in the Same Site.
    Clin Lab 2016 Aug;62(8):1507-1514
    Background: B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC), suggesting a tumor-promoting activity of those cells. Taking into consideration that numerous OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs), involving e. Read More

    Frequency of FOXP3+ Regulatory T-cells in the Blood of Chronic Hepatitis C Patients with Immune Mediated Skin Manifestations; Relationship to Hepatic Condition and Viral Load.
    Clin Lab 2016 Dec;62(12):2339-2348
    Background: Chronic hepatitis C (CHC) infection causes a wide range of immune mediated hepatic and extrahepatic manifestations. Cutaneous manifestations constitute a major portion of the latter group. Host immune response to the virus - particularly regulatory T lymphocytes - is important in determining the outcome of the infection and the possibility of extrahepatic manifestations. Read More

    2016 European guideline for the management of vulval conditions.
    J Eur Acad Dermatol Venereol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Sexual Health, Churchill Hospital, Oxford, UK.
    Vulval conditions may present to a variety of clinicians, such as dermatologists, gynaecologists and general practitioners. Women with these conditions are best managed by a multidisciplinary approach, which includes clear referral pathways between disciplines or access to a specialist multidisciplinary vulval service. Informed consent is a prerequisite for all examinations, investigations and treatments. Read More

    Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL?
    Med Oral Patol Oral Cir Bucal 2017 Feb 4. Epub 2017 Feb 4.
    Faculdade de Odontologia de Piracicaba - UNICAMP, Departamento de Diagnóstico Oral - Semiologia, Av. Limeira, 901 CEP 13.414-903, Piracicaba - São Paulo - Brasil,
    In their recent publication, Garcia-Pola et al. (2016) suggested the development of proliferative verrucous leukoplakia (PVL) in oral lichen planus (OLP). It was described as a preliminary study, where this association supposedly occurred (1). Read More

    The use of topical corticosteroides in the treatment of oral lichen planus in Spain: A national survey.
    Med Oral Patol Oral Cir Bucal 2017 Feb 4. Epub 2017 Feb 4.
    Eduardo Anitua Foundation, C/ Jose Maria Cagigal 19, 01007 Vitoria, Spain
    Background: Explore the treatment of oral lichen planus with topical corticosteroids by the healthcare professionals in Spain.

    Material And Methods: A questionnaire targeted health professionals who treat OLP, in particular maxillofacial surgeons, dermatologist and dentist. The dissemination of the questionnaires was conducted through professional associations and dental and medical societies. Read More

    Eradication of damaged keratinocytes in cutaneous lichen planus forms demonstrated by evaluation of epidermal and follicular expression of CK15, indices of apoptosis and regulatory protein S100.
    Pol J Pathol 2016 ;67(3):258-269
    Department of Physics, Riga Stradins University, Riga, Latvia.
    The study of cytoskeleton arrangement and its contribution to survival of cell-to-cell contacts appears to be essential for understanding of numerous cellular and tissue processes. Applying CK15, S100 labeling and TUNEL reaction to cutaneous lichen planus subtypes, we found CK15 expression in the outer and inner root sheath of hair follicles, the basal epidermal layer, and eccrine glands. Its follicular expression was decreased in nearby inflammatory infiltrates. Read More

    Autoimmune Disease Manifestations in the Oral Cavity.
    Surg Pathol Clin 2017 Mar 28;10(1):57-88. Epub 2016 Dec 28.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA.
    Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns. Read More

    Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy.
    Bioinformation 2016 15;12(3):131-134. Epub 2016 Jun 15.
    Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.; Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore, Lahore, Pakistan.
    Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN) therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. Read More

    Corneal Involvement by Lichen Planus Pigmentosus.
    Ocul Immunol Inflamm 2017 Feb 1:1-3. Epub 2017 Feb 1.
    b Shahid Beheshti Hospital, Kashan University of Medical Sciences , Kashan , Iran.
    Importance: Lichen planus pigmentosus (LPP) is an exclusive form of lichen planus (LP) characterized by pigmentary incontinence in histopathologic slides.

    Observations: We report a known case of LPP with ocular manifestations including pigmented eyelid margins and conjunctival and corneal pigmented lesions. Histopathologic and confocal scanning findings of these lesions were compatible with the diagnosis of underlying systemic disease. Read More

    Swiss Dent J 2017 ;127(1):27-37
    Poliklinik für Zahnärztliche Prothetik und Werkstoffkunde, Universitätsklinikum Leipzig, Leipzig, Germany.
    Allergen-triggered lichenoid oral mucosa lesions may occur both in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Clinically, OLP and OLL are difficult to distinguish from each other. An OLP should be checked by histological examination. Read More

    Unusual Interface Dermatoses Distributed Along Blaschko's Lines in Adult Patients.
    Am J Dermatopathol 2017 Feb;39(2):144-149
    *Department of Pathology, Clinical Hospital, Santiago de Compostela, Spain; †Department of Pathology and Forensic Sciences, University of Santiago de Compostela, Santiago de Compostela, Spain; ‡Department of Dermatology, Clinical Hospital, Santiago de Compostela, Spain; and §Department of Dermatology, Hospital da Barbanza, Ribeira, Spain.
    Linear dermatoses are unusual entities whose distribution reflects cutaneous mosaicism, even when they occur in adult life. Adult blaschkitis (AB) and lichen striatus (LS) always follow this peculiar distribution. Although usually referred to as distinct entities, the clinical and histopathological presentation of lichen striatus in adults may be similar to those of adult blaschkitis. Read More

    Lichen Planus With Predominate Plasma Cell Infiltrate: Two Case Reports.
    Am J Dermatopathol 2017 Feb;39(2):140-143
    *Department of Dermatology, Lehigh Valley Health Network, Allentown, PA; †School of Osteopathic Medicine, Western University Health Sciences, Pomona, CA; and ‡Advanced Dermatology Associates, LTD, Allentown, PA.
    Lichen planus (LP) is a mucocutaneous inflammatory dermatitis of idiopathic origin that can involve the skin, mucous membranes, hair, and nails. LP has an associated set of characteristic histopathologic findings which include hyperkeratosis, vacuolization of the basal layer, Civatte bodies, wedge-shaped hypergranulosis, band-like lymphocytic infiltrate at the dermal epidermal junction, eosinophilic colloid bodies in the papillary dermis, and pigment incontinence. The infiltrate is usually composed of lymphocytes with few histiocytes, mast cells, and macrophages. Read More

    Next step: functional studies on hypertension, lichen planus and TRPA1 connections.
    Oral Dis 2017 Jan 28. Epub 2017 Jan 28.
    Department of Pharmacology and Pharmacotherapy, University of Pecs Medical School, Pecs, Hungary.
    We would like to thank for the invaluable insights of Shan and colleagues (Shan et al, 2017). They put forward a most logical hypothesis for a link between Koebner phenomenon and the mechanoreceptor Transient Receptor Potential Ankyrin 1 (TRPA1). As suggested, TRPA1 expression in non-lesion mucosal areas of oral lichen planus (OLP) patients should also be investigated. Read More

    Primary Biliary Cholangitis Associated with Skin Disorders: A Case Report and Review of the Literature.
    Arch Immunol Ther Exp (Warsz) 2017 Jan 25. Epub 2017 Jan 25.
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona, Bellinzona, Switzerland.
    Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease. It is often associated with extrahepatic autoimmune diseases. Skin disorders are sporadically reported in association with PBC. Read More

    Increased circulating CXCR5(+) CD4(+) T follicular helper-like cells in oral lichen planus.
    J Oral Pathol Med 2017 Jan 25. Epub 2017 Jan 25.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
    Background: CD4(+) T helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T helper cells, has been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated. Read More

    A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series.
    Photodiagnosis Photodyn Ther 2017 Jan 21. Epub 2017 Jan 21.
    Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland; Dental Practice, ul. Waszyngtona 1/34, 15-269 Białystok, Poland.
    Background: Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of EOLP. Read More

    Update on Frontal Fibrosing Alopecia.
    Actas Dermosifiliogr 2017 Jan 20. Epub 2017 Jan 20.
    Servicio de Dermatología, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, España.
    Frontal fibrosing alopecia (FFA) is an increasingly common acquired primary scarring alopecia, first described by Kossard in 1994. Clinically it is characterized by frontotemporal hairline recession, frequently accompanied by eyebrow loss. FFA was initially thought to have a hormonal origin as it was first described in postmenopausal women and premenopausal women with a history of hysterectomy or early menopause. Read More

    Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis.
    Vet Pathol 2017 Jan 1:300985816688754. Epub 2017 Jan 1.
    3 Department of Pathology, Microbiology and Immunology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA.
    Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Read More

    [Frontal fibrosing alopecia: case series and literature review].
    Rev Med Inst Mex Seguro Soc 2017 Jan-Feb;55(1):118-122
    Departamento de Dermatología, Hospital General Dr Manuel Gea González, Ciudad de México, México.
    Frontal fibrosing alopecia is a disease characterized by a symmetric and progressive loss of hair in the fronto-temporal and fronto-parietal lines that generally affects postmenopausal women. It is considered a variant of lichen planus pilaris for its clinical and histopathological features; although, its etiopathology is still unknown. In this report, we analyzed 4 cases of this disease and we discussed its clinical and histopathological characteristics, as well as their course after initiating treatment. Read More

    Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products.
    Clin Oral Investig 2017 Jan 13. Epub 2017 Jan 13.
    Section for Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Medical and Health Sciences, University of Copenhagen, 20 Noerre Allé, 2200, Copenhagen N, DK, Denmark.
    Objective: Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact allergies to dental materials and oral hygiene products in these patients.

    Methods: Forty-nine patients (7 men, 42 women) aged 31 to 77 years (61 ± 10. Read More

    Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
    Medicine (Baltimore) 2017 Jan;96(2):e5075
    aDepartment of Dental Surgery bDepartment of Endocrinology, Brest University Hospital, Brest cDepartment of Dermatology, Quimper Hospital, Quimper dDepartment of Oral Surgery, Brest University Hospital, Brest, France.
    Background: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Read More

    Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study.
    Acta Inform Med 2016 Dec;24(6):390-393
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.

    Methods: In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Read More

    Bilateral retinal vasculitis in a patient with lichen planus.
    Arq Bras Oftalmol 2016 Nov-Dec;79(6):402-403
    Department of Ophthalmology, İnönü University Turgut Özal Medical Center, Malatya, Turkey.
    Lichen planus (LP) is an autoimmune, inflammatory disease of unknown etiology that commonly affects the skin and mucous membranes. Retinal vasculitis is a group of vision-threatening disorders, in which autoimmunity is thought to play a role in pathogenesis. We present the case of a patient who was diagnosed with retinal vasculitis and who was followed up for mucosal LP. Read More

    Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients.
    Braz Oral Res 2017 Jan 5;31:e10. Epub 2017 Jan 5.
    Isfahan University of Medical Sciences, Department of Oral and Maxillofacial Medicine, Isfahan, Iran.
    This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. Read More

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