9,297 results match your criteria Lichen Planus


Topical hyaluronic acid in the management of oral lichen planus: A comparative study.

J Investig Clin Dent 2018 Dec 17:e12385. Epub 2018 Dec 17.

Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Jouf University, Sakaka, Saudi Arabia.

Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disorder seen in clinical dental practice. Despite the progress in research and advances in knowledge, the successful management of OLP is still difficult to achieve. The aim of the present study was to compare the therapeutic effects of triamcinolone (TA) preparation (0. Read More

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http://dx.doi.org/10.1111/jicd.12385DOI Listing
December 2018

Lichen planus: altered AIM2 and NLRP1 expression in skin lesions and defective activation in peripheral blood mononuclear cells.

Clin Exp Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Investigation in Medicine, LIM-56, Department of Dermatology, Tropical Medicine Institute of São Paulo, University of São Paulo Medical School, São Paulo, Brazil.

Background: Lichen planus (LP) is an inflammatory skin disease with unknown aetiology. Activation by pathogen-associated molecular patterns or environmental stimuli may activate some components of inflammasomes that contribute to the inflammatory process in LP lesions.

Aim: To characterize the inflammasomes in skin lesions and peripheral blood mononuclear cells (PBMCs) of patients with LP under Toll-like receptor (TLR) activation. Read More

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http://dx.doi.org/10.1111/ced.13859DOI Listing
December 2018
3 Reads

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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http://www.njms.in/text.asp?2018/9/2/184/245349
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http://dx.doi.org/10.4103/njms.NJMS_49_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251297PMC
December 2018
1 Read

Use of ex-press® implant in glaucoma surgery - retrospective study.

Authors:
V Fialová M Váša

Cesk Slov Oftalmol 2018 ;74(1):9-14

Purpose: The objective of the study is to evaluate of primary open-angle glaucoma (POAG) with the use of EX-PRESS drainage implant. Evaluated was the decrease of intraocular pressure (IOP), visus stabilization, perimeter Humphrey - related finding (T 30-2), Heidelberg Retina Tomograph (HRT) and possibility of reducing the local drug therapy.

Patients And Methods: Retrospective data analysis was performed in 40 eyes with POAG in 28 subjects (14 female- and 14 male patients) average-aged 69. Read More

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January 2018

Three cases of incident lichen planus after direct-acting antiviral treatment for hepatitis C.

JAAD Case Rep 2018 Nov 14;4(10):1068-1071. Epub 2018 Nov 14.

Department of Dermatology University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1016/j.jdcr.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250894PMC
November 2018

Reflectance confocal microscopy terminology glossary for non-melanocytic skin lesions: A systematic review.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

Background: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for non-melanocytic lesions (NMLs).

Objective: To review published RCM terms for NMLs and identify likely-synonymous terms.

Methods: Systematic review of original research articles adhering to PRISMA guidelines was conducted until August 19, 2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.007DOI Listing
December 2018
1 Read

The influence of interferon on healthy and diseased skin.

Cytokine 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.022DOI Listing
December 2018
1 Read

Evaluation of the Serum Levels of Galectin-3 in Patients with Oral Lichen Planus Disease.

Oral Dis 2018 Dec 6. Epub 2018 Dec 6.

Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Galectin-3, a member of beta-galactoside-binding proteins, can be found in cytoplasm and nucleus as well as extracellularly in various tissues and involved in many physiological and pathological processes. We aimed to measure the serum levels of galectin-3 in oral lichen planus (OLP) disease and compare the result with that observed in healthy ones.

Materials And Methods: In this cross-sectional study, the serum levels of galectin-3 were measured in 56 healthy individuals and 53 pathologically proven OLP patients including those with atrophic/erosive (33 cases) or reticular (20 cases) lesions, using enzyme-linked immunosorbent assay (ELISA). Read More

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http://doi.wiley.com/10.1111/odi.13012
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http://dx.doi.org/10.1111/odi.13012DOI Listing
December 2018
5 Reads

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: a randomized controlled trial.

Int J Dent Hyg 2018 Dec 2. Epub 2018 Dec 2.

Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.

Objectives: The aim of this randomized, parallel-design, clinical trial was to investigate the effectiveness of an intensive plaque control program with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients.

Methods: A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group. Both groups were enrolled in an intensive control program comprising supragingival scaling and polishing, and brush-specific instructions for a period of 8 weeks. Read More

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http://doi.wiley.com/10.1111/idh.12377
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http://dx.doi.org/10.1111/idh.12377DOI Listing
December 2018
3 Reads

Pigmented skin lesions displaying regression features: dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Methods: Observational retrospective study. Read More

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http://doi.wiley.com/10.1111/exd.13853
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http://dx.doi.org/10.1111/exd.13853DOI Listing
December 2018
4 Reads

Analysis of Immunologic Function Changes in Lichen Planus After Clinical Treatment.

Med Sci Monit 2018 Dec 2;24:8716-8721. Epub 2018 Dec 2.

Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, China (mainland).

BACKGROUND Lichen planus (LP) is a common chronic superficial skin lesion that causes chronic or sub-acute inflammatory disorders. LP can affect the oral cavity, skin, mucous membrane, and other body parts, and features include repeat attacks and long duration, leading to lower quality of life. This study aimed to analyze the changes of immunologic function before and after treatment of LP. Read More

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https://www.medscimonit.com/abstract/index/idArt/910931
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http://dx.doi.org/10.12659/MSM.910931DOI Listing
December 2018
2 Reads

Notch dysregulation and HS: let's talk about Numb.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

We read with great interest the article by J. W. Frew regarding Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Diseases. Read More

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http://dx.doi.org/10.1111/bjd.17509DOI Listing
December 2018
3 Reads

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies.

Medicina (Kaunas) 2018 Dec 3;54(6). Epub 2018 Dec 3.

Oral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. Read More

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http://dx.doi.org/10.3390/medicina54060099DOI Listing
December 2018
1 Read

Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development.

Arch Dermatol Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, Kyorin University School of Medicine, 6-20-2, Shinkawa Mitaka, Tokyo, 181-8611, Japan.

No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), which allows accurate quantification of individual sweat glands/ducts actively delivering sweat in a well-defined location, to evaluate sweating disturbance in LP lesions. Read More

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http://dx.doi.org/10.1007/s00403-018-1882-0DOI Listing
December 2018
2 Reads

Evaluation of Serum Desmoglein 1 and Desmoglein 3 in Oral Erosive Lichen Planus before and after Topical Application of Tacrolimus.

J Contemp Dent Pract 2018 Oct 1;19(10):1204-1213. Epub 2018 Oct 1.

Department of Oral Surgery, Maxillofacial and Diagnostic Science, College of Dentistry, Qassim University, KSA.

Aim: The current study will attempt to throw light on the role of desmoglein 1 and desmoglein 3 in the pathogenesis of erosive lichen planus and their response to topical application of tacrolimus.

Materials And Methods: Twenty patients with erosive oral lichen planus received tacrolimus ointment three times daily for eight weeks. Assessments using the clinical score and a visual analog scale were recorded at each visit. Read More

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October 2018
2 Reads

Oral lichen-planus-associated fibroblasts acquire myofibroblast characteristics and secrete pro-inflammatory cytokines in response to Porphyromonas gingivalis lipopolysaccharide stimulation.

BMC Oral Health 2018 Nov 29;18(1):197. Epub 2018 Nov 29.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.

Background: Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease in which comprehensive inflammation-related cytokines are involved. These cytokines are commonly produced by immune cells and specific nonimmune cells including keratinocytes, endothelial cells and fibroblasts. This raises the question of whether fibroblasts in OLP lesions contribute to the inflammatory process upon inflammatory simulation. Read More

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http://dx.doi.org/10.1186/s12903-018-0656-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267065PMC
November 2018
2 Reads

Labial adhesions in postmenopausal women: presentation and management.

Int Urogynecol J 2018 Nov 28. Epub 2018 Nov 28.

Department of Urogynaecology, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore, 229899, Singapore.

Labial adhesion is defined as complete or partial fusion of the labia minora in the midline through flimsy or dense adhesions. It may be congenital or acquired. Acquired cases are mainly seen in oestrogen deficiency states in prepubertal girls and postmenopausal women. Read More

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http://dx.doi.org/10.1007/s00192-018-3821-1DOI Listing
November 2018
1 Read

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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http://dx.doi.org/10.5826/dpc.0804a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246064PMC
October 2018
2 Reads

IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus.

Arch Oral Biol 2018 Nov 17;98:115-121. Epub 2018 Nov 17.

Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China. Electronic address:

Objective: The aim of the present study was to investigate the correlation between IL-25 expression and disease severity, and the potential immunoregulatory role of IL-25 expression in oral lichen planus (OLP).

Materials And Methods: The oral mucosal tissue samples obtained from OLP patients and healthy controls (HCs) were analyzed for IL-25 expression by real-time quantitative PCR (qPCR) and immunohistochemistry. Recombinant IL-25 was used to stimulate OLP patient-derived CD4 + T cells, and then IL-4 secretion and mRNA expression were evaluated by ELISA and qPCR, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183036
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http://dx.doi.org/10.1016/j.archoralbio.2018.11.015DOI Listing
November 2018
5 Reads

The Expression of CXCL10/CXCR3 and Effect of the Axis on the Function of T Lymphocyte Involved in Oral Lichen Planus.

Inflammation 2018 Nov 22. Epub 2018 Nov 22.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.

The etiology of oral lichen planus (OLP) is still not clear. The purpose of this study was to explore the role of CXC chemokine receptor 3(CXCR3) and its ligand CXC motif chemokine 10(CXCL10) in the pathogenesis of OLP. We examined the expression of CXCR3 and CXCL10 in OLP patients and healthy controls by quantitative real-time PCR, Western blotting, ELISAs, and immunohistochemistry, respectively. Read More

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http://dx.doi.org/10.1007/s10753-018-0934-0DOI Listing
November 2018
1 Read

Facial and Extrafacial Lesions in an Ethnically Diverse Series of 91 Patients with Frontal Fibrosing Alopecia Followed at a Single Center.

Dermatology 2018 Nov 22:1-8. Epub 2018 Nov 22.

Background: Various facial and extrafacial lesions have been reported in frontal fibrosing alopecia (FFA). Facial papules have been associated with worse prognosis.

Objectives: We sought to detect the prevalence of facial and extrafacial lesions and to analyze their relation to demographic and clinical variables in a large and ethnically diverse series of patients with FFA. Read More

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http://dx.doi.org/10.1159/000494603DOI Listing
November 2018
1 Read

CHRONIC ULCERATIVE STOMATITIS: a comprehensive review and proposal for diagnostic criteria.

Oral Dis 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Medical University of Warsaw, Poland.

Chronic ulcerative stomatitis (CUS) is an immune-mediated disorder characterized by oral erosions and ulcers usually refractory to conventional treatments. The disease often involves middle-aged and older women with painful lesions sometimes resembling those of erosive oral lichen planus (OLP). The most affected sites are the buccal mucosa, the gingiva and the tongue, but the skin is involved in 22. Read More

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http://doi.wiley.com/10.1111/odi.13001
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http://dx.doi.org/10.1111/odi.13001DOI Listing
November 2018
7 Reads

Soft Tissue Disorders of the Mouth.

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

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http://dx.doi.org/10.1016/j.emc.2018.09.006DOI Listing
February 2019
8 Reads

Treatment of Cutaneous Lichen Planus (Part 2): A Review of Systemic Therapies.

J Dermatolog Treat 2018 Nov 17:1-40. Epub 2018 Nov 17.

b Department of Dermatology , University of KwaZulu-Natal & Nelson Mandela School of Medicine , Durban , South Africa.

Background: Although numerous medications are available for the treatment of cutaneous lichen planus (CLP), recurrence is common and there is a lack of evidence of efficacy of many treatment options. Part 1 reviewed consolidated evidence from topical therapies and phototherapy. In Part 2, all systemic treatments are assessed. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1544411DOI Listing
November 2018
4 Reads

Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study.

Australas J Dermatol 2018 Nov 18. Epub 2018 Nov 18.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.

Background/objectives: Lichen planus-like keratoses (LPLK) are benign skin lesions that can mimic malignancy; the clinical and dermoscopic features distinguishing lichen planus-like keratoses from skin tumors have not been extensively studied. The objective of this study was to identify dermoscopic features that may prevent unnecessary biopsies of lichen planus-like keratoses.

Methods: Retrospective, observational study of biopsied skin lesions. Read More

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http://dx.doi.org/10.1111/ajd.12955DOI Listing
November 2018
4 Reads

A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: A case series.

Photodiagnosis Photodyn Ther 2018 Nov 14. Epub 2018 Nov 14.

Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269, Białystok, Poland; Dental Practice, ul. Waszyngtona 1/34, 15-269, Białystok, Poland.

Background: The aim of the study was to clinically evaluate the efficacy of photodynamic therapy in treatment of reticular oral lichen planus (OLP).

Methods: Fifty patients aged 26-84, with 124 OLP lesions in total, underwent photodynamic therapy (PDT) mediated with topically applied 5% 5-aminolevulinic acid. ALA was activated by a custom-made diode lamp with a high-power LED emitting light at 630 nm and 300 mW delivered through an optical fiber probe. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183021
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http://dx.doi.org/10.1016/j.pdpdt.2018.11.009DOI Listing
November 2018
6 Reads

Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183288
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http://dx.doi.org/10.1016/j.jaad.2018.09.060DOI Listing
November 2018
4 Reads

Circulating exosomes regulate T-cell-mediated inflammatory response in oral lichen planus.

J Oral Pathol Med 2018 Nov 17. Epub 2018 Nov 17.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Background: Exosomes are newly recognized natural nanocarrier and intercellular messenger that emerge as important mediators of signal transmission. Exosomes have been reported to modulate the inflammatory response of a number of diseases. This study investigated the effects of circulating exosomes from oral lichen planus (OLP) on T cells. Read More

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http://doi.wiley.com/10.1111/jop.12804
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http://dx.doi.org/10.1111/jop.12804DOI Listing
November 2018
3 Reads

Differential Diagnosis of Cheilitis - How to Classify Cheilitis?

Acta Clin Croat 2018 Jun;57(2):342-351

Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g. Read More

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https://hrcak.srce.hr/index.php?show=clanak&id_clanak_je
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http://dx.doi.org/10.20471/acc.2018.57.02.16DOI Listing
June 2018
7 Reads

Hypertrophic lichen planus mistaken for squamous cell carcinoma.

Med J Aust 2018 Nov;209(10):462

Mater Hospital Brisbane, Brisbane, QLD.

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November 2018

Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia Mimicking Discoid Lupus Erythematosus.

Arthritis Rheumatol 2018 Nov 14. Epub 2018 Nov 14.

Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania, USA.

A 77-year old Caucasian woman presented with a 10-year history of discoid, scaly, pigmented, telangiectatic and atrophic patches on the upper cheeks (Figure 1), and gradually progressive alopecia of the frontal scalp (Figure 2). A biopsy of the cheek demonstrated interface dermatitis, epidermal hyperkeratosis and atrophy, dyskeratotic keratinocytes, and a superficial perivascular lymphohistiocytic infiltrate with pigment incontinence. She had a low-titer ANA (1:80, nucleolar), negative SS-A and SS-B, and unremarkable blood counts/chemistry. Read More

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http://dx.doi.org/10.1002/art.40779DOI Listing
November 2018
1 Read

Herbal medicine in oral lichen planus.

Phytother Res 2018 Nov 12. Epub 2018 Nov 12.

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Oral lichen planus (OLP) is a common chronic inflammatory and T cell-mediated autoimmune disease in which the oral mucosa, tongue, and gingiva are involved. Different treatments have been suggested to reduce the symptoms of this disease. Currently, a common treatment for OLP is the use of corticosteroids as the gold standard, although they have considerable side effects. Read More

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http://doi.wiley.com/10.1002/ptr.6236
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http://dx.doi.org/10.1002/ptr.6236DOI Listing
November 2018
7 Reads

Deregulated phospholipase D2/mammalian target of rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with disease severity.

Arch Oral Biol 2018 Nov 3;98:26-31. Epub 2018 Nov 3.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, PR China. Electronic address:

Objective: Oral lichen planus (OLP) is a common T lymphocyte-mediated autoimmune disease of unknown etiology. The mammalian target of rapamycin (mTOR) can regulate proliferation, apoptosis, and autophagy of T lymphocytes, therefore impacting the T lymphocyte-mediated immunity. The present study was aimed to investigate the possible association between Akt/mTOR/4E-BP1 (eIF4E-binding protein 1) signaling, phospholipase D (PLD) and hypoxia-inducible factor 1 alpha (Hif-1α) in peripheral T lymphocytes of OLP and the correlation of their expression with the disease severity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183021
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http://dx.doi.org/10.1016/j.archoralbio.2018.11.003DOI Listing
November 2018
3 Reads

Psoriasis in a cohort of patients with common variable immunodeficiency.

Br J Dermatol 2018 Nov 10. Epub 2018 Nov 10.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Italy.

Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency in adults. CVID is characterized by reduced serum levels of IgG, IgA, and/or IgM, recurrent bacterial infections, autoimmune and inflammatory diseases and malignancies. According to literature, autoimmune diseases occur in 20-30% of CVID patients. Read More

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http://doi.wiley.com/10.1111/bjd.17408
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http://dx.doi.org/10.1111/bjd.17408DOI Listing
November 2018
8 Reads

Multidermatomal zosteriform lichen planus pigmentosus-a unique presentation.

Int J Dermatol 2018 Nov 9. Epub 2018 Nov 9.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/ijd.14292DOI Listing
November 2018
1 Read

Lichen planopilaris: Retrospective study on the characteristics and treatment of 291 patients.

J Dermatolog Treat 2018 Nov 9:1-28. Epub 2018 Nov 9.

a Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences , Tehran , Iran .

Lichen planopilaris (LPP) is an immune-mediated cicatricial alopecia. The main clinical presentations of LPP include classic form, frontal fibrosing alopecia (FFA), and Graham-Little-Piccardi-Lassueur syndrome (GLPLS). We reviewed medical records of all 291 patients diagnosied with LPP from 2006 to 2017 in Department of Dermatology, Tehran University of Medical Sciences. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1542480DOI Listing
November 2018
3 Reads

Masked pemphigus among pediatric patients with Castleman's disease.

Int J Rheum Dis 2018 Nov 8. Epub 2018 Nov 8.

Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan.

Aim: Paraneoplastic pemphigus (PNP) is a mucocutaneous autoimmune disorder accompanied with a neoplasm. Castleman's disease (CD), although rare, is the most common cause of PNP in children. It can be life-threatening when pulmonary involvement occurs. Read More

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http://dx.doi.org/10.1111/1756-185X.13407DOI Listing
November 2018
6 Reads

Hydroxychloroquine sulphate therapy of erosive oral lichen planus.

Australas J Dermatol 2018 Nov 8. Epub 2018 Nov 8.

Department of Dermatology, Rambam Medical Center, Haifa, Israel.

Background/objectives: Erosive oral lichen planus (LP) may be painful and debilitating. Symptomatic oral LP has been treated with a wide spectrum of topical and systemic therapies, but few have been evaluated in large series. Hydroxychloroquine is suggested to be effective in oral LP. Read More

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http://doi.wiley.com/10.1111/ajd.12948
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http://dx.doi.org/10.1111/ajd.12948DOI Listing
November 2018
3 Reads

Hyperpigmented Upper Eyelid: A Clue to the Diagnosis of Facial Lichen Planus Pigmentosus in a Patient with Frontal Fibrosing Alopecia.

Skin Appendage Disord 2018 Oct 4;4(4):335-338. Epub 2018 Apr 4.

Universidade Federal Fluminense, Niterói, Brazil.

Facial lichen planus pigmentosus (LPPig), a rare variant of classic lichen planus, was first described in patients with frontal fibrosing alopecia (FFA) by Dlova [Br J Dermatol 2013; 168: 439-442] in 2013. The diagnosis of facial LPPig is sometimes not easy, since clinical signs and histopathological features may frequently be confused with melasma or postinflammatory hyperpigmentation. We describe a case of a postmenopausal black woman diagnosed with FFA who presented with an identical brown-grayish pigmentation of the face and upper eyelids and typical dermoscopy analysis on both regions. Read More

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https://www.karger.com/Article/FullText/487338
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http://dx.doi.org/10.1159/000487338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219244PMC
October 2018
6 Reads

Oral prednisone: A unique and effective treatment for actinic lichen planus.

JAAD Case Rep 2018 Nov 29;4(10):976-978. Epub 2018 Oct 29.

Department of Dermatology, Naval Medical Center San Diego, San Diego, California.

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http://dx.doi.org/10.1016/j.jdcr.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214885PMC
November 2018
1 Read

Estrogen reinforces barrier formation and protects against tumor necrosis factor alpha-induced barrier dysfunction in oral epithelial cells.

J Periodontal Implant Sci 2018 Oct 24;48(5):284-294. Epub 2018 Oct 24.

Department of Oral Microbiology and Immunology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

Purpose: Epithelial barrier dysfunction is involved in the pathophysiology of periodontitis and oral lichen planus. Estrogens have been shown to enhance the physical barrier function of intestinal and esophageal epithelia, and we aimed to investigate the effect of estradiol (E2) on the regulation of physical barrier and tight junction (TJ) proteins in human oral epithelial cell monolayers.

Methods: HOK-16B cell monolayers cultured on transwells were treated with E2, an estrogen receptor (ER) antagonist (ICI 182,780), tumor necrosis factor alpha (TNFα), or dexamethasone (Dexa), and the transepithelial electrical resistance (TER) was then measured. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5051/jpis.2018.4
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http://dx.doi.org/10.5051/jpis.2018.48.5.284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207799PMC
October 2018
3 Reads

Frontal Fibrosing Alopecia in Women: The Mayo Clinic Experience With 148 Patients, 1992-2016.

Mayo Clin Proc 2018 Nov;93(11):1581-1588

Surgical Dermatology Group, Birmingham, AL. Electronic address:

Objective: To characterize the clinicopathologic findings, comorbidities, and treatment outcomes of women with frontal fibrosing alopecia.

Patients And Methods: Retrospective review of women with frontal fibrosing alopecia at Mayo Clinic from January 1, 1992, to February 22, 2016. The terms "scarring alopecia," "lichen," "planopilaris," "fibrosing," and "alopecia" were used for the search of female patients aged 1 to 100 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183052
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http://dx.doi.org/10.1016/j.mayocp.2018.05.036DOI Listing
November 2018
16 Reads

Reticular Oral Lichen Planus.

Head Neck Pathol 2018 Nov 2. Epub 2018 Nov 2.

Department of Anatomic Pathology, Naval Medical Center San Diego, San Diego, CA, USA.

Reticular oral lichen planus is a common clinical finding, often found incidentally on routine oral examination. Patients rarely complain of symptoms and the condition does not require treatment, as a result, biopsies and ancillary laboratory evaluation are seldom performed. We present a case of reticular oral lichen planus with a classic clinical presentation and characteristic histologic findings. Read More

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http://link.springer.com/10.1007/s12105-018-0983-6
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http://dx.doi.org/10.1007/s12105-018-0983-6DOI Listing
November 2018
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Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review.

J Dermatolog Treat 2018 Nov 2:1-7. Epub 2018 Nov 2.

a Department of Stomatology , First Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou , China.

Objective: Oral lichen planus (OLP) is a relatively common immunological mucocutaneous disease that causes pain and poor quality of life. Curcumin has been reported to be a safe and effective treatment for OLP. The objective of this review is to evaluate the existing evidence for the safety of curcumin in treating OLP as well as its efficacy compared with that of corticosteroids. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1543849DOI Listing
November 2018
3 Reads

New Functions of Classical Compounds against Orofacial Inflammatory Lesions.

Medicines (Basel) 2018 Nov 1;5(4). Epub 2018 Nov 1.

Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of this is a disease known as stomatitis; although stomatitis itself is not a life-threatening disease, it severely impairs the individual's quality of life, and thus a standard therapeutic strategy for it has already been established. The topical application of a bioactive agent is quite easy, and a strong anti-inflammatory agent can be used without significant adverse effects. Read More

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http://dx.doi.org/10.3390/medicines5040118DOI Listing
November 2018
4 Reads

Oral lichen planus and its relationship with systemic diseases. A review of evidence.

J Clin Exp Dent 2018 Sep 1;10(9):e938-e944. Epub 2018 Sep 1.

MD, DDS, PhD. Doctor, Specialist in Stomatology. Professor of Oral Pathology, Faculty of Medicine and Health Sciences (School of Dentistry), University of Barcelona - Head of the Medical Surgical Area and Medical Director of Dentistry Hospital Barcelona University / Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, Spain.

Background: Oral lichen planus (OLP) is one of the most common dermatological diseases which are present in the oral cavity. It is a chronic autoimmune, mucocutaneous disease that affects the oral mucosa as well as the skin, genital mucosa and other sites.

Objective: Review the relevant information to OLP and its relationship with systemic diseases. Read More

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http://www.medicinaoral.com/medoralfree01/aop/55145.pdf
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http://dx.doi.org/10.4317/jced.55145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203921PMC
September 2018
4 Reads

Lichen Planopilaris Caused by Wig Attachment: A Case of Koebner Phenomenon in Frontal Fibrosing Alopecia.

Int J Trichology 2018 Jul-Aug;10(4):172-174

Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.

Frontal fibrosing alopecia (FFA) represents a distinctive condition with a marginal scarring alopecia along the frontal and temporal hairline. Since its original description, the condition has been recognized to represent a more generalized than localized process, with extension beyond the frontotemporal hairline to include the parieto-occipital hairline and involve peculiar facial papules as evidence of facial vellus hair involvement and loss of peripheral body hair. Finally, the association of FFA with oral lichen planus, nail involvement, and concomitant lichen planopilaris (LPP) points to a close relationship to lichen planus. Read More

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http://www.ijtrichology.com/text.asp?2018/10/4/172/242923
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http://dx.doi.org/10.4103/ijt.ijt_48_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192232PMC
November 2018
3 Reads

Different expression patterns of carbonic anhydrase IX in oral lichen planus and leukoplakia.

Acta Odontol Latinoam 2018 Aug;31(2):77-81

Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Anatomía Patológica, Argentina.

Tumor hypoxia is an important indicator of cancer prognosis. Among the different genes that are upregulated by hypoxia is carbonic anhydrase IX, which combines carbon dioxide and water to form bicarbonate and hydrogen. Although expression of this enzyme is very low in normal tissues, carbonic anhydrase IX is overexpressed in several types of cancer. Read More

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August 2018
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