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    How general dentists could manage a patient with oral lichen planus.
    Med Oral Patol Oral Cir Bucal 2018 Feb 24. Epub 2018 Feb 24.
    VU University Medical Center (VUmc)/ ACTA Department of Oral and Maxillofacial Surgery and Pathology P.O. Box 7057 1007 MB, Amsterdam, The Netherlands
    Background: The literature hardly contains information on how patients suffering from oral lichen planus could be managed by dentists.

    Material And Methods: Based on the limited available literature and particularly on the long-term clinical and histopathological experience of one of the authors, suggestions on how dentists could manage patients with oral lichen planus have been put forward.

    Results: In most cases, the dentist should be able to establish a correct diagnosis. Read More

    Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
    J Formos Med Assoc 2018 Feb 19. Epub 2018 Feb 19.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. Read More

    Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?
    J Low Genit Tract Dis 2018 Feb 22. Epub 2018 Feb 22.
    Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
    Objective: The aim of the study was to assess for the presence of vulvar lichen planus (LP) in association with human papillomavirus (HPV)-independent squamous cell carcinoma (SCC).

    Materials And Methods: We performed a clinicohistopathologic review of consecutive vulvectomies and wide local excisions for HPV-independent vulvar or vaginal SCC from 2007 to 2017. Data collected included site of SCC, adjacent precursor lesions and dermatoses, dermatologic treatment, and outcome. Read More

    Nivolumab reactivation of hypertrophic lichen planus, a case report and review of published literature.
    Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.
    College of Medicine, University of Arizona, Tucson, Arizona.
    We report a case of nivolumab-induced lichen planus (LP) reactivation that was previously in remission following chemotherapy for non-smallcelllung cancer (NSCLC). Chemotherapy-induced immunosuppression allowed for complete resolution of the patient's pre-existing LP, a T-cell mediatedautoimmune process. When the patient was switched to nivolumab immunotherapy owing to progression of NSCLC, PD-1 inhibition led to an overwhelming T-cell response that seemed to have provoked a severe LPreactivation. Read More

    Accuracy of Dermoscopic Criteria for the Diagnosis of Melanoma In Situ.
    JAMA Dermatol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Dermatology, University of Campania, Naples, Italy.
    Importance: The accuracy of melanoma-specific dermoscopic criteria has been tested mainly in studies including invasive tumors. Scarce evidence exists on the usefulness of these criteria for the diagnosis of melanoma in situ (MIS).

    Objective: To investigate the diagnostic accuracy of dermoscopic criteria for the diagnosis of MIS. Read More

    Blastomycosis-like Pyoderma Arising in Lichen Planus.
    J Drugs Dermatol 2018 Feb;17(2):233-235
    Blastomycosis-like pyoderma (BLP) is a rare reactive skin disease that is most commonly caused by bacterial infection. Herein we present a case of BLP arising in lichen planus, a chronic inflammatory disease. We propose Wolf's isotopic response, or the appearance of a new skin disease at the site of an existing and unrelated disease, as the underlying molecular mechanism responsible for this unusual physical presentation. Read More

    Lichen planus: molecular pathway and clinical implications in oral disorders.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):135-138
    Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Naples, Italy.
    Stem cells play a role in many mucosal disorders characterised by abnormal proliferation and differentiation of keratinocytes, such as oral lichen planus (OLP). In OLP there were changes in stem cell markers as component of integrin complexes α6 and β1 integrin increased along with increase of melanoma-associated chondroitin sulphate proteoglycan (MCSP) and decreased of notch1 (N1) and keratin 15 (K15). Stem cell marker expression may be altered by pathological signalling in these lesions. Read More

    Psychiatric disorders in oral lichen planus: a preliminary case control study.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):97-100
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    The aim of this study was to evaluate the prevalence of psychiatric symptoms in patients with oral lichen planus (OLP) compared to a control group. Eleven patients (mean age 65.2 years-old), with diagnosis of OLP and 13 controls (mean age 64. Read More

    Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus.
    Clin Exp Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Davis Medical Center, University of California-Davis, Sacramento, CA, USA.
    Background: Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy.

    Aim: To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa. Read More

    Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):701-710. Epub 2017 Nov 29.
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan.
    Hepatitis C virus (HCV) infection is frequently associated with various extrahepatic manifestations, such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one such extrahepatic manifestation of HCV infection. Recently, direct-acting antivirals (DAA) have proved to be highly effective and safe for the eradication of HCV. Read More

    Increased infiltration of CD11 c/CD123dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 18. Epub 2017 Dec 18.
    Department of Oral Mucosal Diseases, Ninth People's Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China; National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:
    Objective: Investigation of dendritic cell (DC) subsets and expression patterns of Toll-like receptors (TLRs) was conducted to understand the pathogenesis in oral lichen planus (OLP).

    Study Design: Blood, OLP lesion, and control samples were collected. Four DC subsets (CD11cCD123myeloid DC1 [mDC1], CD141mDC2, CD11cCD123plasmacytoid DC [pDC], and CD1aCD207Langerhans cells [LC]) were investigated via flow cytometry (FCM) and immunohistochemical staining. Read More

    Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.
    J Formos Med Assoc 2018 Feb 7. Epub 2018 Feb 7.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Efficacy of photodynamic therapy and low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus.
    Photodiagnosis Photodyn Ther 2018 Feb 4. Epub 2018 Feb 4.
    Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Electronic address:
    Background: The efficacy of photodynamic therapy (PDT) and low level laser therapy (LLLT) in the treatment of oral lichen planus (OLP) is debatable. The aim of this study was to compare the effects of PDT and LLLT with topical corticosteroid application in the treatment of erosive-atrophic OLP.

    Materials And Methods: Forty-five adult patients with erosive-atrophic biopsy-proven OLP on the tongue or buccal mucosa (size ≤3 cm) were randomly divided into three groups. Read More

    The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus.
    J Oral Pathol Med 2018 Feb 7. Epub 2018 Feb 7.
    Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China.
    Background: The present study was to investigate association and potentially destructive role of Th9/IL-9 and their synergistic interaction with Th17 cells in elevating MMP9 production in local lesions of oral lichen planus (OLP) patients.

    Methods: Oral mucosal tissues were obtained from OLP patients and healthy controls (HC) and then divided into an epithelial part (EP) or a lamina propria part (LP). Both EP and LP subsets were assessed for IL-9 and MMP9 mRNA levels by real-time quantitative PCR (qPCR). Read More

    Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus.
    Dermatol Ther 2018 Feb 6. Epub 2018 Feb 6.
    Microbiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    The aim of this study was to evaluate the safety and efficacy of Bacillus Calmette-Guerin, polysaccharide nucleic acid (BCG-PSN) therapy in the treatment of oral and cutaneous LP. Twenty-four LP patients were included in this study and classified randomly into; Oral LP group (OLP), 11 patients and Cutaneous LP group (CLP), 13 patients. All patients received intradermal injections of BCG-PSN, twice weekly for three weeks. Read More

    Oral potentially malignant disorders: risk of progression to malignancy.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    UWA Dental School, The University of Western Australia, Nedlands, Australia.
    Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Read More

    Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):456-457
    Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.
    Context: The malignant transformation potential of oral lichen planus (OLP) and related lesions is a subject of great controversy.

    Aim: The aim of this study was to compare the expression of proteins related to apoptosis and tumour suppressor gene processes in OLP, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD).

    Materials And Methods: The immunohistochemical study was carried out to investigate the expressions of survivin and p53 in a total of 30 lesional biopsy specimens - 10 cases each of OLP, OLR and OLD. Read More

    Estimation of silver nucleolar organizer regions in oral lichen planus, oral lichenoid reactions and oral lichenoid dysplasia.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):454
    Department of Oral Pathology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
    Aims And Objective: (1) To study the clinical and histological features of oral lichen planus, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD). (2) To estimate and compare the silver nucleolar organizer regions in OLR and OLD.

    Materials And Methods: A total of 40 biopsies were studied; sections were divided as study group, which consists of OLP, OLR and OLD each of 10 cases and 10 biopsies of normal oral mucosa as control group. Read More

    Evaluation of oxidative stress markers in oral lichen planus.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):387-393
    Department of Oral Pathology, Azeezia College of Dental Sciences and Research, Kollam, Kerala, India.
    Background: Lichen planus (LP) is a chronic, inflammatory disease that affects the skin, mucous membrane, scalp and nails that frequently involves the oral mucosa. Oxidative stress reflects an imbalance between the production of reactive oxygen species and the biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. It has been suggested that oxidative stress may play a role in the pathogenesis of LP. Read More

    Salivary proteomics in lichen planus: A relationship with pathogenesis?
    Oral Dis 2018 Jan 30. Epub 2018 Jan 30.
    Department of Stomatology School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
    Objectives: Oral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocytes pathways induce apoptosis with an increase of Th1 and Th17 subtypes cells, triggered by the release of cytokines; This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease.

    Material And Methods: Proteins differentially expressed by oral lichen planus and healthy controls were screened using mass spectrometry; the proteins found in oral lichen planus were subjected to bioinformatics analysis, including gene ontology and string networks analysis. Read More

    [Lichenoid drug reactions].
    Hautarzt 2018 Feb;69(2):116-120
    Klinik für Dermatologie & Allergologie, RWTH Aachen University, Aachen, Deutschland.
    Lichenoid drug reactions are rare compared to typical morbilliform drug exanthema or urticaria. They are associated with specific drugs or drug families like gold, antimalarial drugs, β‑blockers and angiotensin-converting-enzyme inhibitors. Recent observations included associations with novel drugs such as biologics (e. Read More

    Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients.
    Arch Dermatol Res 2018 Jan 24. Epub 2018 Jan 24.
    Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
    Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cells against basal epithelial cells. MicroRNAs (MiRNAs) are short non-coding RNA that plays critical role in gene expression at post-transcriptional levels. Much evidence showed that miRNAs play an important role in regulating immune response and cancer development. Read More

    Clinical profile of 300 men with facial hypermelanosis.
    J Dermatol Case Rep 2017 Dec 1;11(2):20-24. Epub 2017 Dec 1.
    Department of Dermatology, Venereology & Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda)-176001 (Himachal Pradesh), India.
    Background: Facial hypermelanosis is a significant cause of cosmetic disfigurement, social embarrassment and psychological morbidity affecting quality of life.

    Objective: To study clinicoepidemlogic patterns of facial hypermelanoses among men.

    Material And Methods: Medical records of all adult males presenting with facial hypermelanoses were analyzed for this retrospective cross sectional study for demographic details, duration, cosmetic usage, sun exposure, drug intake, infections, systemic or cutaneous diseases, and family history of hypermelanotic dermatosis. Read More

    Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus.
    Clin Exp Otorhinolaryngol 2018 Jan 26. Epub 2018 Jan 26.
    Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University Medical Center, Seoul, Korea.
    Objectives: To examine the factors which affect the improvement or the recurrence of disease after intralesional steroid injection in patients with oral lichen planus (OLP).

    Methods: Sixty-two patients diagnosed as OLP were treated with intralesion corticosteroid injection. To evaluate the objective severity of OLP, total severity score of OLP was assessed. Read More

    Pityriasis Rosea: Diagnosis and Treatment.
    Am Fam Physician 2018 Jan;97(1):38-44
    Emory University School of Medicine, Atlanta, GA, USA.
    Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

    Piccardi-Lassueur-Graham-Little syndrome associated with frontal fibrosing alopecia.
    An Bras Dermatol 2017 Nov-Dec;92(6):867-869
    Department of Dermatology, Hospital Universitari Sagrat Cor - Barcelona, Spain.
    Piccardi-Lassueur-Graham-Little syndrome is a rare entity characterized by progressive scarring alopecia of the scalp and keratotic papules on hairless skin, associated with non-scarring alopecia in the axilla and pubic area or lichen planus lesions. We describe the case of a 70-year-old woman who presented a Piccardi-Lasseur-Graham-Little syndrome, along with frontal fibrosing alopecia. Read More

    Psychopathological profile and quality of life of patients with oral lichen planus.
    J Appl Oral Sci 2018 Jan 18;26:e20170146. Epub 2018 Jan 18.
    Wroclaw Medical University, Department of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw, Poland.
    Oral lichen planus (OLP) is a chronic, multifocal, sometimes painful, inflammatory disease of the oral mucosa. OLP can predispose development of psycho-emotional disorders. Until now, the relationship between the severity of lichen planus and the psychological profile of patients (psychological well-being, perceived stress and pain coping strategies) has never been studied. Read More

    Lichen planus and lichenoid drug eruption after vaccination.
    Cutis 2017 Dec;100(6):E6-E20
    Harvard School of Public Health, Boston, Massachusetts, USA; and National Skin Centre, Singapore.
    Lichen planus (LP) and lichenoid drug eruptions (LDEs) uncommonly occur after vaccination, especially for hepatitis B and influenza. The key initiating event that leads to the development of postimmunization LP or LDE is not well understood. There have been prior reports of an association between several vaccines and LP. Read More

    Lichen planus pemphigoides treated with ustekinumab.
    Cutis 2017 Dec;100(6):415-418
    Advanced Desert Dermatology/Midwestern University, Glendale, Arizona, USA.
    A 71-year-old woman presented with pink to violaceous, flat-topped, polygonal papules on the volar wrists, extensor elbows, and bilateral lower legs of 3 years' duration. She also had erythematous, violaceous, infiltrated plaques with microvesiculation on the bilateral thighs of several months' duration. She reported pruritus, burning, and discomfort. Read More

    Squamous cell carcinoma from oral lichen planus: a case report of a lesion with 28 years of evolution.
    J Korean Assoc Oral Maxillofac Surg 2017 Dec 27;43(Suppl 1):S14-S18. Epub 2017 Dec 27.
    Department of Dentistry, Sagrado Coração University, Bauru, Brazil.
    Lichen planus (LP) is a relatively common mucocutaneous disease with autoimmune etiology. Considering its malignancy potential, it is important to define the correct diagnosis, treatment, and clinical follow-up for patients with LP so that the disease is not diagnosed late, thus hindering the chances of curing the disease. This study aims to describe a clinical case of oral squamous cell carcinoma, potentially originated from LP. Read More

    Melanoma in situ mimicking a Lichen planus-like keratosis.
    Acta Biomed 2018 Jan 16;88(4):496-498. Epub 2018 Jan 16.
    General and Specialist Surgery Department, Plastic Surgery Division, University of Siena, Italy.
    The incidence of melanoma has steadily increased over the past three decades. Melanoma in situ (MIS),  defined as melanoma that is limited to the epidermis, contributes to a disproportionately high percentage of this rising incidence. Amelanotic melanoma presents as an erythematous macule or plaque and may initially be misdiagnosed as an inflammatory disorder. Read More

    Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review.
    J Oral Pathol Med 2018 Jan 19. Epub 2018 Jan 19.
    Department of Oral Medicine and Diagnostic Sciences, AlFarabi Colleges, Riyadh, Saudi Arabia.
    Background: The aim of this study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus (OLP).

    Materials And Methods: PubMed/MEDLINE, Scopus, and ISI Web of knowledge were searched until July 2017, using the following keywords: OLP, erosive lichen planus, lichen planus, and PDT.

    Results: Five clinical studies were included. Read More

    Possible role of plasmacytoid dendritic cells in pityriasis lichenoides.
    Clin Exp Dermatol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
    Background: Plasmacytoid dendritic cells (pDCs) and their product, type I interferons (IFNs), have been implicated in the pathogenesis of several skin disorders characterized by an interface dermatitis (ID) pattern, such as lichen planus (LP). A type I IFN signature has previously been documented in pityriasis lichenoides (PL). Although pDCs are known to be the main source and most potent producers of local type I IFNs, their role in PL has not been investigated. Read More

    Association between hepatitis C infection in Thai patients with oral lichen planus: A case-control study.
    J Investig Clin Dent 2018 Jan 18. Epub 2018 Jan 18.
    Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
    Aim: The aim of the present study was to investigate the prevalence of hepatitis C virus (HCV) infection and evaluate liver enzyme levels in patients from upper northern Thailand with oral lichen planus (OLP).

    Methods: A case-control study of 101 patients with OLP and 101 patients without OLP was conducted. Peripheral blood was taken from each patient and screened for anti-HCV antibody using immunochromatography. Read More

    Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
    Background: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. Read More

    LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus.
    Sci Rep 2018 Jan 15;8(1):763. Epub 2018 Jan 15.
    Department of Stomatology, Shanxi Medical University, Taiyuan, Shanxi, China.
    The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. Read More

    [Lichen ruber planus : Better understanding, better treatment!]
    Hautarzt 2018 Feb;69(2):100-108
    Klinik für Dermatologie, Venerologie und Allergologie, Campus Homburg, Gebäude 6.7, Universität des Saarlandes, Homburg, Deutschland.
    Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. Read More

    Dysplasia Should Not Be Ignored in Lichenoid Mucositis.
    J Dent Res 2018 Jan 1:22034517748639. Epub 2018 Jan 1.
    1 Faculty of Dentistry, the University of British Columbia, Vancouver, BC, Canada.
    Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. Read More

    Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
    Environ Toxicol 2018 Jan 12. Epub 2018 Jan 12.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Read More

    Lichen planus following tetanus-diphtheria-acellular pertussis vaccination: A case report and review of the literature.
    SAGE Open Med Case Rep 2018 4;6:2050313X17750335. Epub 2018 Jan 4.
    Department of Dermatology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
    Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4. Read More

    Nail changes in alopecia areata: an update and review.
    Int J Dermatol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
    Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer-reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms "nail changes alopecia areata," "alopecia areata nails," and specific searches on "trachyonychia alopecia areata" and "pitting alopecia areata. Read More

    Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
    J Dermatolog Treat 2018 Jan 31:1-7. Epub 2018 Jan 31.
    a Department of Neurosciences, Reproductive and Odontostomatological Sciences , University Federico II of Naples , Naples , Italy.
    Objectives: We sought to determine the efficacy of psychotropic drug in the management of BMS-like oral symptoms in patients with reticular oral lichen planus (R-OLP) refractory to conventional therapies, and its impact on anxious and depressive symptoms.

    Materials And Methods: We enrolled 28 cases of symptomatic R-OLP. The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2). Read More

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