10,995 results match your criteria Lichen Planus


Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: A long-term study of 34 patients.

J Oral Pathol Med 2022 May 20. Epub 2022 May 20.

Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela.

Background: Proliferative verrucous leukoplakia (PVL) is considered an uncommon oral potentially malignant disorder with a high malignant transformation (MT) rate. The objective of this paper was to define its cancer incidence and related risk factors.

Methods: A retrospective audit of 34 patients diagnosed with PVL from a university-based unit, during the period from 1995 to 2019 was performed. Read More

View Article and Full-Text PDF

The efficacy of injectable platelet-rich fibrin in the treatment of symptomatic oral lichen planus.

Oral Dis 2022 May 20. Epub 2022 May 20.

Oral Diagnostic and Surgical Sciences, UWA Dental School, The University of Western Australia, Perth, WA, Australia.

Objectives: The use of autologous platelet concentrates has shown growing evidence as a promising therapy. We conducted a split-mouth study to evaluate the effectiveness of injectable platelet-rich fibrin (PRF) compared to triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).

Materials And Methods: This split-mouth randomized trial included twelve patients with symptomatic, bilateral OLP lesions. Read More

View Article and Full-Text PDF

A Delphi consensus on the nomenclature and diagnosis of lichen planus pigmentosus and related entities.

Indian J Dermatol Venereol Leprol 2022 Apr 4:1-6. Epub 2022 Apr 4.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Although well known in clinical practice, research in lichen planus pigmentosus and related dermal pigmentary diseases is restricted due to lack of consensus on nomenclature and disease definition.

Aims And Objectives: Delphi exercise to define and categorise acquired dermal pigmentary diseases.

Methods: Core areas were identified including disease definition, etiopathogenesis, risk factors, clinical features, diagnostic methods, treatment modalities and outcome measures. Read More

View Article and Full-Text PDF

A Retrospective Study of 23 Cases: Are Lichenoid Lesions of the Labial Mucosa Induced?

Cureus 2022 May 15;14(5):e25012. Epub 2022 May 15.

Département de Pathologie de la Muqueuse Buccale, Service de Chirurgie Maxillo-Faciale et Stomatologie, Pitié-Salpêtrière Hospital, Paris, FRA.

Background Lichen planus (LP) is a pathology that affects the skin and the mucosa. The lips are rarely involved but represent a diagnostic challenge in those cases. Oral lichenoid lesions (OLL) are defined as lesions that resemble oral lichen planus (OLP) but do not fully meet the clinical and/or histologic criteria for OLP. Read More

View Article and Full-Text PDF

Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine).

BMC Oral Health 2022 May 18;22(1):184. Epub 2022 May 18.

Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy.

Background: Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP.

Methods: 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. Read More

View Article and Full-Text PDF

Oral Lichen Planus: Associations Between Histomorphometric Characteristics and White and Red Lesions.

Head Neck Pathol 2022 May 17. Epub 2022 May 17.

Postgraduate Program in Interactive Processes of Organs and Systems of the Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil.

Histomorphometry seems to provide more rigid quantitative elements for histological analysis and to bring less subjectivity to the diagnosis of oral lichen planus lesions (OLP). This study aimed to verify the association between white and red lesions and histomorphometric characteristics of OLP lesions. This retrospective cross-sectional study assessed 48 hematoxylin- and eosin-stained histological sections from incisional biopsies obtained from OLP cases. Read More

View Article and Full-Text PDF

The genomic and proteomic landscape in oral lichen planus versus oral squamous cell carcinoma: a scoping review.

Int J Dermatol 2022 May 16. Epub 2022 May 16.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: Oral lichen planus (OLP), a World Health Organization (WHO)-classified oral potentially malignant condition, confers a 1% risk of transformation to oral squamous cell carcinoma (OSCC). There does not appear to be a consensus understanding of the underlying molecular events. This scoping review aimed to identify critical molecular pathways and highlight gaps in existing knowledge on malignant transformation in OLP. Read More

View Article and Full-Text PDF

The fluorescent immunocytochemical diagnostics of precancerous diseases and cancer of the oral mucosa.

Klin Lab Diagn 2022 Apr;67(4):219-226

Federal budgetary institution of science "Nizhny Novgorod research Institute of epidemiology and microbiology named after academician I.N. Blokhina Rospotrebnadzor".

Purpose of the study improving the diagnosis of precancerous diseases and cancer of the oral mucosa using fluorescent immunocytochemical studies by direct immunofluorescence. A clinical laboratory examination of 111 patients was carried out: 46 patients with squamous cell carcinoma of the oral mucosa, 35 people with precancerous lesions (17 leukoplakia, 18 - oral lichen planus) and 30 healthy people. All patients underwent a traditional cytological examination and an additional immunocytochemical examination by direct immunofluorescence, the expression levels of tumor markers P53, P16 and Ki67 were determined. Read More

View Article and Full-Text PDF

Differential Retrospective Analysis in Oral Cancerous, Pre-cancerous, and Benign Tissue Biopsies.

Cureus 2022 May 13;14(5):e24956. Epub 2022 May 13.

Department of Oral and Maxillofacial Surgery, National and Kapodistrian University of Athens, Dental School, Athens, GRC.

Background/Aim Oral epithelia demonstrate a broad spectrum of pre-cancerous, cancerous, and benign lesions. The aim of this study was to record and analyze the prevalence of various oral and intraosseous lesions, highlighting malignancies that are hard to clinically identify as such too. Materials and methods A series of 536 oral lesions were collected covering a period of 8. Read More

View Article and Full-Text PDF

Concurrent autoimmune orofacial lesions: A rare occurrence!

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):98-100. Epub 2022 Mar 31.

Department of General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Autoimmune disorders occur either as a solitary lesion or in pairs, but it is unusual to find two autoimmune disease lesions in the oral cavity in a single patient, who has been previously treated for psoriasis. We present the case of a 30-year-old male who presented with complaints of severe burning in the oral cavity. Examination revealed the presence of co-occurrence of vitiligo with oral lichen planus with a history of psoriasis and was managed conservatively with good response to treatment. Read More

View Article and Full-Text PDF

Evaluation of salivary oxidative stress in oral lichen planus using malonaldehyde.

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):26-30. Epub 2022 Mar 31.

Department of Oral Pathology and Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Oral lichen planus is a chronic, mucocutaneous, inflammatory disease, with an unknown etiology. Reactive oxygen species and oxidative damage to the tissues might be the cause. Malonaldehyde (MDA), a low molecular weight end product of lipid peroxidation reaction is a suitable biomarker of endogenous DNA damage. Read More

View Article and Full-Text PDF

Potential role of interleukin-17 in the pathogenesis of oral lichen planus: A systematic review with meta-analysis.

J Eur Acad Dermatol Venereol 2022 May 15. Epub 2022 May 15.

Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease of unknown etiology, which may evolve into squamous cell carcinoma. Recent advances on OLP pathogenesis suggest the presence of Th17 cells and the up-regulation of interleukin-17 (IL-17) expression are crucial events. Our aim was to test the hypothesis in the literature about an important role of IL-17 in OLP by systematically investigating the overexpression of IL-17 in the lesional tissue and blood from OLP patients and healthy controls. Read More

View Article and Full-Text PDF

Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.

Cells 2022 Apr 27;11(9). Epub 2022 Apr 27.

Department of Oral Biology and Diagnostic Sciences, The Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.

Adrenal glands are the major source of glucocorticoids, but recent studies indicate tissue-specific production of cortisol, including that in the oral mucosa. Both endogenous and exogenous glucocorticoids regulate the production of several proteins, including the glucocorticoid-induced leucine zipper (GILZ) and Annexin A1, which play important roles in the regulation of immune and inflammatory responses. Common inflammation-associated oral conditions include lichen planus and candidiasis, but the status of GILZ and Annexin A1 in these human conditions remains to be established. Read More

View Article and Full-Text PDF

Comparative efficacy of topical coconut cream and clobetasol propionate ointment for the management of oral lichen planus: A double-blinded randomized control trial.

Indian J Pharmacol 2022 Mar-Apr;54(2):84-89

Department of Oral Medicine and Radiology, KAHER's KLE Vishwanath Katti Institute of Dental Sciences, JNMC Campus, Belagavi, Karnataka, India.

Context: Oral lichen planus (OLP) is a quite common chronic inflammatory mucocutaneous disorder affecting the oral cavity and skin. The current treatment relies on systemic or topical corticosteroids but is known to cause side effects thereby demanding a search for an alternative.

Aim: This study aims to assess and to compare the efficacy of topical Coconut (Cocos nucifera) 50% cream and Clobetasol propionate 0. Read More

View Article and Full-Text PDF

Shoreline Nails: A New Nail Sign of SARS-CoV-2 Infection.

J Drugs Dermatol 2022 May;21(5):521-522

With the onset of the SARS-CoV-2 pandemic, a number of nail unit changes have been associated with SARS-CoV-2 infection. We report a new unique nail finding within one month of infection and RT-PCR test positivity characterized by an abrupt proximal superficial nail plate change characteristic of shoreline nails. The possibility that this nail change may represent a Koebner phenomenon in patients prone to lichen planus is raised. Read More

View Article and Full-Text PDF

The expression of salivary microRNAs in oral lichen planus: Searching for a prognostic biomarker.

Pathol Res Pract 2022 Apr 26;234:153923. Epub 2022 Apr 26.

Stem Cell Technology Research Center, Tehran, Iran. Electronic address:

Oral lichen planus (OLP) is a premalignant disease with unknown etiology. It has been demonstrated that inflammation and immune activation play a central role in the pathogenesis of OLP. Various cellular and molecular mechanisms are involved in the pathogenesis of OLP. Read More

View Article and Full-Text PDF

Oral lichen planus: comparative efficacy and treatment costs-a systematic review.

BMC Oral Health 2022 05 6;22(1):161. Epub 2022 May 6.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital/ Dana Farber Cancer Institute, Boston, USA.

Objective: To compare the reported efficacy and costs of available interventions used for the management of oral lichen planus (OLP).

Materials And Methods: A systematic literature search was performed from database inception until March 2021 in MEDLINE via PubMed and the Cochrane library following PRISMA guidelines. Only randomized controlled trials (RCT) comparing an active intervention with placebo or different active interventions for OLP management were considered. Read More

View Article and Full-Text PDF

The clinical evolution of lichen planus pemphigoides.

Proc (Bayl Univ Med Cent) 2022 4;35(3):352-353. Epub 2022 Feb 4.

Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, Texas.

Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by lichenoid and bullous lesions. LPP is generally thought to be idiopathic, possibly related to medication or malignancy, or potentially the result of long-standing lichenoid inflammation damaging the basement membrane zone leading to epitope spreading. The histological appearance of lichenoid and bullous lesions in LPP resembles findings of lichen planus and bullous pemphigoid, respectively. Read More

View Article and Full-Text PDF
February 2022

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer.

Front Pharmacol 2022 20;13:825266. Epub 2022 Apr 20.

Computational Biology and Bioinformatics Lab, Institute of Life Sciences, Bhubaneswar, India.

Among oral diseases, oral cancer is a critical health issue due to its life-threatening potential. Globocan, in its 2020 report, estimated ∼0.37 million new cases of oral cancer, with the majority of them coming from the Asian continent. Read More

View Article and Full-Text PDF

Identifying predictors of systemic immunosuppressive treatment of vulvovaginal lichen planus: A retrospective cohort study of 122 women.

Australas J Dermatol 2022 May 2. Epub 2022 May 2.

Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Background: Between 20% and 40% of women with vulvovaginal lichen planus (VLP) fail to respond to first-line ultra-potent topical corticosteroid treatment and require systemic immunosuppression to control disease. No data exist regarding risk factors for patients with severe VLP requiring systemic immunosuppression. We aimed to identify clinical features that predict women with VLP who are at risk of severe, recalcitrant disease requiring eventual escalation to systemic treatment. Read More

View Article and Full-Text PDF

Lichenoid eruption in a child receiving growth hormone for dwarfism.

Dermatol Online J 2022 Jan 15;28(1). Epub 2022 Jan 15.

Department of Dermatology, King Fahd Specialist Hospital, Buraydah, Qassim, Saudi Arabia.

A wide variety of medications have been associated with lichenoid drug eruption. They present similarly or even identically to idiopathic lichen planus, both clinically and histologically. Lichenoid eruption has been associated with recombinant human growth hormone intake in two previous patients. Read More

View Article and Full-Text PDF
January 2022

Successful Treatment of Nail Lichen Planus with a Lacquer Containing Urea, Keratinase, and a Retinoid Molecule: Report of 10 Cases.

Case Rep Dermatol 2022 Jan-Apr;14(1):43-48. Epub 2022 Mar 21.

Outpatient Podiatry Medicine Clinic, Alcamo, Italy.

Lichen planus is chronic inflammatory mucocutaneous disease. Involvement of nails (nail lichen planus: NLP) could be the only manifestation or it could be associated with the other typical skin and mucous localizations. Typical NLP alterations are linear nail bed dyschromia, longitudinal ridging, splitting, onycholysis, and subungual hyperkeratosis. Read More

View Article and Full-Text PDF

Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus the STING Pathway.

Front Immunol 2022 14;13:838109. Epub 2022 Apr 14.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Background: Damaged and dead cells release cell-free DNA (cfDNA) that activates cyclic GMP-AMP (cGAMP) synthase (cGAS), which leads to the activation of stimulator of interferon genes (STING) the second messenger cGAMP. STING promotes the production of inflammatory cytokines and type I interferons to induce an inflammatory response. Oral lichen planus (OLP), a chronic autoimmune disease involving oral mucosa characterized by the apoptosis of keratinocytes mediated by T-lymphocytes, is related to the activation of multiple inflammatory signaling pathways. Read More

View Article and Full-Text PDF

[Translated article] Frontal Fibrosing Alopecia and Lichen Planus Pigmentosus: Variants of the Same Disea×se?

Actas Dermosifiliogr 2022 Apr 26. Epub 2022 Apr 26.

Departamento de Dermatología. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

View Article and Full-Text PDF

Esophageal lichen planus successfully treated with the JAK1/3 inhibitor tofacitinib.

J Dtsch Dermatol Ges 2022 Apr 28. Epub 2022 Apr 28.

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany.

View Article and Full-Text PDF

The clinical impact of direct-acting antiviral treatment on patients affected by hepatitis C virus-related oral lichen planus: a cohort study.

Clin Oral Investig 2022 Apr 27. Epub 2022 Apr 27.

Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Miraglia, Naples, Italy.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease. Literature supports an association between OLP and Hepatitis C virus (HCV) infection. The current treatment for HCV infection with direct-acting antivirals (DAAs) is highly effective and safe. Read More

View Article and Full-Text PDF

RNAi-based modulation of IFN-γ signaling in skin.

Mol Ther 2022 Apr 27. Epub 2022 Apr 27.

RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address:

Aberrant activation of interferon (IFN)-γ signaling plays a key role in several autoimmune skin diseases, including lupus erythematosus, alopecia areata, vitiligo, and lichen planus. Here, we identify fully chemically modified small interfering RNAs (siRNAs) that silence the ligand binding chain of the IFN-γ receptor (IFNGR1), for the modulation of IFN-γ signaling. Conjugating these siRNAs to docosanoic acid (DCA) enables productive delivery to all major skin cell types local to the injection site, with a single dose of injection supporting effective IFNGR1 protein reduction for at least 1 month in mice. Read More

View Article and Full-Text PDF

Differential diagnosis between pemphigoid and erosive lichen planus.

J Appl Oral Sci 2022 04 20;30:e20210657.res. Epub 2022 Apr 20.

Canakkal Onsekiz Mart University, Faculty of Dentistry, Department of Periodontology, Canakkale, Turkey.

View Article and Full-Text PDF