4,072 results match your criteria Leydig Cell Tumors

Update on Ovarian Sex Cord-Stromal Tumors.

Zehra Ordulu

Surg Pathol Clin 2022 Jun;15(2):235-258

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, 1345 Center Drive, Box 100275, Gainesville, FL 32610, USA. Electronic address:

This article focuses on the recent advances in ovarian sex cord-stromal tumors, predominantly in the setting of their molecular underpinnings. The integration of genetic information with morphologic and immunohistochemical findings in this rare subset of tumors is of clinical significance from refining the diagnostic and prognostic stratifications to genetic counseling. Read More

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Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China.

Front Med (Lausanne) 2022 31;9:816012. Epub 2022 May 31.

Department of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, China.

Objectives: To report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.

Patients And Methods: From 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidemiological parameters, clinical characteristics, tumor markers, therapy, and follow-up data. Read More

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Reinke crystals: Hallmarks of adult Leydig cells in humans.

Andrology 2022 Jun 4. Epub 2022 Jun 4.

Department of Histology and Embryology, University of Zagreb School of Medicine, Zagreb, Croatia.

Background: Reinke crystals are structures pathognomonic for Leydig cells, which have the important function of testosterone production and are vital for male reproductive health. These crystalline inclusions are thought to be of protein origin; however, the molecular composition has not yet been resolved.

Objectives: This review summarizes all available information regarding Reinke crystal's characteristics and aims to produce a comprehensive guide for research on this topic as well as to determine and discuss potential Reinke-protein candidates. Read More

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Clinicopathologic Features and Proposed Grossing Protocol of Orchiectomy Specimens Performed for Gender Affirmation Surgery.

Hum Pathol 2022 Jun 2. Epub 2022 Jun 2.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Gender affirmation surgery performed for gender dysphoria is increasing to instigate changes more closely approximating gender identity. We investigated the clinicopathologic features of gender affirming orchiectomies performed at our institution and devised a grossing protocol for these increasingly encountered specimens. We obtained 45 orchiectomies from 23 patients and reviewed clinicopathologic features. Read More

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From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach.

Gynecol Endocrinol 2022 Jun 1:1-6. Epub 2022 Jun 1.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.

About 5% of all ovarian tumors develop some form of hormonal activity. Only 1% of ovarian tumors will secrete androgens causing clinical hyperandrogenism. Most androgen-secreting neoplasms (ASN) derive from sex cord or stroma cells of the ovary and may affect both premenopausal and postmenopausal women. Read More

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Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway.

Cells 2022 05 19;11(10). Epub 2022 May 19.

Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible molecular mechanism of melatonin regarding cisplatin-induced oxidative stress in testicular tissue and Leydig cells. Read More

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Pure Sertoli cell tumor of the ovary: A case report.

Clin Case Rep 2022 May 23;10(5):e05892. Epub 2022 May 23.

Department of Obstetrics and Gynecology Tribhuvan University Teaching Hospital Maharajgunj Nepal.

Pure Sertoli cell tumors are an uncommon variant of rare ovarian Sertoli-Leydig cell tumors. Due to nonspecific clinical and imaging features, diagnosis is often made after histopathological examination. The prognosis is excellent as most are detected in the early stages and surgical resection is often curative in most cases. Read More

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Barriers to achieving a cure in lymphoma.

Cancer Drug Resist 2021 5;4(4):965-983. Epub 2021 Nov 5.

Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.

Lymphoma is a diverse disease with a variety of different subtypes, each characterized by unique pathophysiology, tumor microenvironment, and underlying signaling pathways leading to oncogenesis. With our increasing understanding of the molecular biology of lymphoma, there have been a number of novel targeted therapies and immunotherapy approaches that have been developed for the treatment of this complex disease. Despite rapid progress in the field, however, many patients still relapse largely due to the development of drug resistance to these therapies. Read More

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November 2021

Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys.

Eur J Med Res 2022 May 12;27(1):67. Epub 2022 May 12.

Service de Radiologie, APHP Hôpitaux Paris Saclay, Hôpital Antoine Béclère, 157 rue de la porte de trivaux, 92140, Clamart, France.

Background: We report the challenging case of a 6-year-old boy with precocious puberty related to histologically proven Leydig cell tumor.

Case Presentation: Multiparametric ultrasound and magnetic resonance imaging (MRI) was performed. Interesting findings were scarcely or never reported in children and differed from adults Leydig cell tumors s such as the hyperechogenic halo surrounding the lesion and the dominant central vascularization using ultrasensitive Doppler. Read More

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Anastomosing Hemangioma of the Ovary With Leydig Cell Hyperplasia: A Clinicopathologic Study of 12 Cases.

Int J Gynecol Pathol 2022 Apr 12. Epub 2022 Apr 12.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Anastomosing hemangioma is a recently described vascular neoplasm, initially identified in the male genitourinary tract. Since its first description, it has been reported at multiple anatomic sites, including rare cases in the female genital tract, most in the ovary. Herein we report the largest series to date of 12 ovarian anastomosing hemangiomas identified at our institution over a 15-yr period. Read More

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Clinical and pathological patterns of non-epithelial malignant ovarian tumours in Western Saudi Arabia.

Niger Postgrad Med J 2022 Apr-Jun;29(2):116-122

Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Objective: To report a single-center experience in non-epithelial malignant ovarian tumours (NEMOT), by presenting different clinical and pathological characteristics, management and outcomes.

Methods: We retrospectively reviewed electronic files of all female patients who underwent surgery for NEMOT at the Gynecology Department of King Abdulaziz University Hospital, Jeddah, Saudi Arabia, from July 2003 to July 2019. We collected baseline demographic, anthropomorphic and clinical data; pathological characteristics; management and follow-up data; and outcomes including residual disease, recurrence and last follow-up status (deceased or alive). Read More

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The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of -mediated K Currents.

Biomedicines 2022 Mar 27;10(4). Epub 2022 Mar 27.

Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.

Isoplumbagin (isoPLB, 5-hydroxy-3-methyl-1,4-naphthoquinone), a naturally occurring quinone, has been observed to exercise anti-inflammatory, antimicrobial, and antineoplastic activities. Notably, whether and how isoPLB, plumbagin (PLB), or other related compounds impact transmembrane ionic currents is not entirely clear. In this study, during GH-cell exposure to isoPLB, the peak and sustained components of an ( related gene)-mediated K current () evoked with long-lasting-step hyperpolarization were concentration-dependently decreased, with a concomitant increase in the decaying time constant of the deactivating current. Read More

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15-Year-Old Patient with an Unusual Alpha-Fetoprotein-Producing Sertoli-Leydig Cell Tumor of Ovary.

Case Rep Obstet Gynecol 2022 12;2022:4759826. Epub 2022 Apr 12.

Department of Pathology, Brugmann University Hospital Center, Université Libre de Bruxelles, Belgium.

Ovarian Sertoli-Leydig cell tumors (SLCTs) are extremely rare ovarian sex-cord stromal tumors. Alpha-fetoprotein (AFP) production by SLCTs is a rare event generally linked to the presence of hepatocytes or intestinal mucinous epithelium as heterologous elements. We report here a case of a 15-year-old female complaining about abdominal pain, constipation, and spaniomenorrhea with high level of serum AFP leading to a clinical suspicion of malignant germ cell tumor. Read More

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Fertility sparing surgery in sex-cord stromal tumors: oncological and reproductive outcomes.

Int J Gynecol Cancer 2022 Apr 18. Epub 2022 Apr 18.

Gynecology Department, I.R.C.C.S. San Raffaele Hospital, Milan, Italy.

Sex cord stromal tumors are rare neoplasms, frequently diagnosed in young women often as early-stage disease. In patients who desire to preserve fertility, when possible, unilateral salpingo-oophorectomy with peritoneal surgical staging is a safe alternative to radical treatment. In this review, we analyze the available literature on the obstetrical outcomes after fertility-sparing surgery in a total of 255 patients with sex cord stromal tumors. Read More

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Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility: A case report.

Int J Surg Case Rep 2022 Apr 9;93:106923. Epub 2022 Mar 9.

Department of Oncology, Aga Khan University, Karachi, Pakistan.

Introduction And Importance: The neoplasms of the testis are sporadic tumors among men. Furthermore, the rarest subset of these is neoplasms belonging to the stromal tumors of the sex cord. Leydig cell tumors are the most common form among the testicular stromal tumors. Read More

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Epidemiological profile and clinico-pathological features of pediatric gynecological cancers at Moi Teaching & Referral Hospital, Kenya.

Gynecol Oncol Rep 2022 Apr 10;40:100956. Epub 2022 Mar 10.

Beaumont Hospitals, MI, USA.

Background: The main pediatric (0-18 years) gynecologic cancers include stromal carcinomas (juvenile granulosa cell tumors and Sertoli-Leydig cell tumors), genital rhabdomyosarcomas and ovarian germ cell. Outcomes depend on time of diagnosis, stage, tumor type and treatment which can have long-term effects on the reproductive career of these patients. This study seeks to analyze the trends in clinical-pathologic presentation, treatment and outcomes in the cases seen at our facility. Read More

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Neuroectodermal elements are part of the morphological spectrum of DICER1-associated neoplasms.

Hum Pathol 2022 05 1;123:46-58. Epub 2022 Mar 1.

Departments of Human Genetics, Medicine and Oncology, McGill University, Montréal, Québec, Canada; Cancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, H3T 1E2.

Many sarcomas with DICER1 pathogenic variants (PVs) exhibit a characteristic morphology, including a subepithelial layer of malignant mesenchymal cells, areas of rhabdomyoblastic differentiation and cartilaginous and/or osseous elements. We report 5 DICER1-associated neoplasms (1 moderately to poorly differentiated Sertoli Leydig cell tumour and 4 sarcomas) containing variable amounts of neuroectodermal elements. The neoplasms predominantly involved or were in close proximity to the female genital tract (ovary, uterine corpus, abdominal and pelvic cavity) and occurred in females aged 14 months to 54 years. Read More

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Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire.

Cureus 2022 Jan 12;14(1):e21165. Epub 2022 Jan 12.

Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research, Kolkata, IND.

Many pathologies can cause gonadotropin-independent precocious puberty (GIPP) in prepubertal boys. Leydig cell tumor is one rare cause of this presentation. Here we present a six-year-old boy with features of isosexual precocious puberty, high testosterone levels, low gonadotropin levels, and bone age advancement. Read More

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January 2022

Highly sensitive bioassay for luteinizing hormone and chorionic gonadotropin allowing their measurement in plasma.

Reprod Fertil 2021 Dec 11;2(4):300-307. Epub 2021 Nov 11.

Institut National de la Recherche Agronomique et environnementale (INRAe), Centre National de la Recherche Scientifique (CNRS), Université de Tours, Joint Laboratory of Reproductive Physiology and Behaviors (PRC), Nouzilly, France.

In previous studies, we had shown the synergistic effect of 10 M forskolin (FSK) on the detection threshold of the cyclic AMP response to luteinizing hormones (LH) and chorionic gonadotropins (CG) from various species in the mouse Leydig tumor cell (mLTC) cell line. Independently, we started to study the effect of 10-10 M oxytocin (OXT) also on the cyclic AMP response to LH and CG preparations on these same cells and found an amplifying effect on the luminescence response caused by gonadotropins. The aim was then to explore the effects of 10-10 M OXT on the gonadotropin-induced cAMP response, in the presence or absence of 10 µM FSK to optimize the assay down to a sensitivity compatible with the detection of the circulating concentrations of these hormones in various species. Read More

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December 2021

Reproductive toxicity investigation of silica nanoparticles in male pubertal mice.

Environ Sci Pollut Res Int 2022 May 22;29(24):36640-36654. Epub 2022 Jan 22.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, People's Republic of China.

Silica nanoparticles (SiNPs), one of the most produced nanoparticles (NPs) in the world, are used in all aspects of life. The increased application of SiNPs, especially in medicine, has raised considerable concern regarding their toxicological impact. Previous studies have shown that SiNPs can pass through the reproductive barrier and cause reproductive organ dysfunction by destroying Sertoli cells, Leydig cells, and germ cells. Read More

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A Matter of Time: Delayed Presentation and Rapid Progression from Gonadotropin-Independent to Gonadotropin-Dependent Precocious Puberty following Successful Treatment for a Leydig Cell Tumor.

Case Rep Pediatr 2022 6;2022:5306138. Epub 2022 Jan 6.

Lady Ridgeway Hospital, Colombo, Sri Lanka.

Leydig cell tumors, most often benign, are a rare cause of isosexual gonadotropin-independent precocious puberty in boys due to secretion of testosterone. Very rarely do these tumors produce estrogen, causing gynecomastia. Testicular sparing surgery is the mainstay of treatment currently although radical orchidectomy was the choice in the past. Read More

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January 2022

Distinct somatic DICER1 hotspot mutations in three metachronous ovarian Sertoli-Leydig cell tumors in a patient with DICER1 syndrome.

Cancer Genet 2022 04 5;262-263:53-56. Epub 2022 Jan 5.

Department of Pathology & Immunology, Baylor College of Medicine, Department of Pathology, Texas Children's Hospital, Houston, TX USA; Texas Children's Cancer Center, Houston, TX USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX USA. Electronic address:

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Medullary bone in male budgerigars () with testicular neoplasms.

Vet Pathol 2022 03 8;59(2):333-339. Epub 2022 Jan 8.

University of Tennessee, Knoxville, TN.

Medullary bone is a calcium-rich, labile bone normally occurring in female birds with each egg-laying cycle. The stimulus for formation of medullary bone is, in part, the cyclic increase in serum estrogens produced by preovulatory ovarian follicles. Increased bone density due to formation of medullary bone, particularly in pneumatic bones, has been termed polyostotic hyperostosis, even if physiologic. Read More

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Anti-steroidogenic effects of cholesterol hydroperoxide trafficking in MA-10 Leydig cells: Role of mitochondrial lipid peroxidation and inhibition thereof by selenoperoxidase GPx4.

Biochem Biophys Res Commun 2022 02 3;591:82-87. Epub 2022 Jan 3.

Department of Biophysics, Jagiellonian University, Krakow, Poland. Electronic address:

Steroid hormone synthesis in steroidogenic cells requires cholesterol (Ch) delivery to/into mitochondria via StAR family trafficking proteins. In previous work, we discovered that 7-OOH, an oxidative stress-induced cholesterol hydroperoxide, can be co-trafficked with Ch, thereby causing mitochondrial redox damage/dysfunction. We now report that exposing MA-10 Leydig cells to Ch/7-OOH-containing liposomes (SUVs) results in (i) a progressive increase in fluorescence probe-detected lipid peroxidation in mitochondrial membranes, (ii) a reciprocal decrease in immunoassay-detected progesterone generation, and ultimately (iii) loss of cell viability with increasing 7-OOH concentration. Read More

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February 2022

Bilateral testicular Leydig cell hyperplasia presented incidentally: A case report.

Int J Surg Case Rep 2022 Jan 27;90:106733. Epub 2021 Dec 27.

Ministry of Health, Jordan.

Introduction: Leydig cell hyperplasia or tumor represents less than 3% of all testicular tumors. It can be defined as an increase in the size and number of Leydig cell within the testicles. These cells are responsible for the production of testosterone in human males. Read More

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January 2022

Testicular Lesions in Infertile Men.

Am J Clin Pathol 2022 Jun;157(6):936-941

Department of Pathology, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.

Objectives: An increasing number of incidental testicular tumors are diagnosed in patients during infertility workup. The aim of this study was to evaluate the accuracy of frozen section examination (FSE) for the management of these tumors.

Methods: We retrospectively studied a series of 46 testicular tumors diagnosed during exploration for infertility from 2000 to 2019 and submitted for FSE. Read More

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Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.

Reprod Biol 2022 Mar 17;22(1):100598. Epub 2021 Dec 17.

Biology Department, Université de Moncton, Moncton, New-Brunswick, E1A 3E9, Canada. Electronic address:

Obesity contributes to a decrease in testosterone production in men. Indeed, adipose tissue produces several hormones, including adiponectin and resistin, and these may influence the activity of signaling pathways responsible for regulating the expression of genes related to steroidogenesis. In this study, we wanted to identify which genes are directly regulated by these hormones using the MA-10 tumor Leydig cell model. Read More

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Effect of androgens on Sertoli cell maturation in human testis from birth to puberty.

Basic Clin Androl 2021 Dec 14;31(1):31. Epub 2021 Dec 14.

Université Claude Bernard Lyon 1, Lyon, France.

Background: Androgens are well known to be necessary for spermatogenesis. The purpose of this study was to determine Sertoli cell responsiveness to androgens according to age from birth to puberty.

Results: Testicular tissue samples were studied in a population of 84 control boys classified into seven groups according to age: group 1 (1-30 days), group 2 (1-3 months), group 3 (3-6 months), group 4 (0. Read More

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December 2021

Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.

Mol Cell Endocrinol 2022 02 4;542:111527. Epub 2021 Dec 4.

Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy.

Type 5 phosphodiesterase (PDE5) blockade by inhibitors (PDE5i) results in intracellular cyclic guanosine monophosphate (cGMP) increase and smooth muscle relaxation and are used for the treatment of men erectile dysfunction. Although they have high specificity for PDE5, these inhibitors are suspected to cross-interact also with cyclic adenosine monophosphate (cAMP)-specific PDEs, inducing the intracellular accumulation of this cyclic nucleotide and related testosterone increase, positively impacting male reproductive parameters. However, the link between the use of PDE5i and the activation of cAMP-mediated steroidogenesis is still unclear. Read More

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February 2022