3,774 results match your criteria Leydig Cell Tumors


Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors.

J Gynecol Oncol 2018 Nov 12. Epub 2018 Nov 12.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.

Objective: To investigate the role of adjuvant chemotherapy (CT) in the management of ovarian non-granulosa cell (GC) sex cord-stromal tumors (SCSTs).

Methods: The National Cancer Database was accessed and patients diagnosed between 2004 and 2013 with a malignant non-GC SCST were selected. Overall survival (OS) was evaluated with Kaplan-Meier curves and compared with the log-rank test. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e19DOI Listing
November 2018

Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline.

Chemosphere 2019 Jan 18;222:722-731. Epub 2019 Jan 18.

Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China; Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Risk Assessment Laboratory of Agro-Products Processing Quality and Safety (Nanjing), Ministry of Agriculture, Nanjing, Jiangsu, China. Electronic address:

Veterinary tetracyclines drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria dysfunction and testosterone disruption in Leydig cells in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.101DOI Listing
January 2019
1 Read

Sertoliform Endometrioid Carcinoma of Ovary Presenting as Abdominal Wall Abscess.

J Midlife Health 2018 Oct-Dec;9(4):222-224

Department of Pathology, JIPMER, Puducherry, India.

Sertoliform endometrioid carcinoma (SEC) is a rare epithelial ovarian cancer which may be mistaken for sex cord tumour on microscopy. Immunohistochemistry and extensive sampling of tumour to look for areas of conventional endometrioid carcinoma are important to confirm the diagnosis of SEC. We report a case of SEC of ovary in a postmenopausal lady who presented to us with abdominal wall abscess in epigastric region. Read More

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http://dx.doi.org/10.4103/jmh.JMH_47_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332725PMC
January 2019
1 Read

Inhibition of Luman/CREB3 expression leads to the upregulation of testosterone synthesis in mouse Leydig cells.

J Cell Physiol 2019 Jan 23. Epub 2019 Jan 23.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.

Luman, also known as cAMP-response element-binding protein 3, is an endoplasmic reticulum stress-related protein that has been identified as a novel transcriptional coregulator of a variety of nuclear receptors. Herein, immunohistochemistry results showed that Luman was specifically expressed in mouse Leydig cells in an age-dependent increase manner, from prepuberty to sexual maturation. Luman was not detected in Sertoli cells within the seminiferous tubules at any developmental period. Read More

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http://doi.wiley.com/10.1002/jcp.28171
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http://dx.doi.org/10.1002/jcp.28171DOI Listing
January 2019
5 Reads
3.839 Impact Factor

[Sex cord-stromal tumors of the ovary : Current aspects with a focus on granulosa cell tumors, Sertoli-Leydig cell tumors, and gynandroblastomas].

Authors:
F Kommoss H-A Lehr

Pathologe 2019 Feb;40(1):61-72

Institut für Pathologie, Medizin Campus Bodensee, Röntgenstr. 2, 88048, Friedrichshafen, Deutschland.

Sex cord-stromal tumors of the ovary (SCSTO) comprise a heterogeneous and fascinating group of neoplasms with diverse clinicopathological features, including benign lesions as well as tumors with malignant potential. Clinically, SCSTO may be associated with hyperestrogenic or androgenic function as a result of steroid hormone production by the tumor cells.Histological diagnosis may be challenging due to complex and sometimes overlapping morphological features of the various tumor types. Read More

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http://dx.doi.org/10.1007/s00292-018-0562-3DOI Listing
February 2019
4 Reads

Early Bilateral Gonadoblastoma Associated With 45,X/46,XY Mosaicism: The Spectrum of Undifferentiated Gonadal Tissue and Gonadoblastoma in the First Months of Life.

Pediatr Dev Pathol 2019 Jan 15:1093526618824469. Epub 2019 Jan 15.

2 Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

45,X/46,XY mosaicism is one of a heterogenous group of congenital conditions known as differences (disorders) of sex development (DSD) that results in abnormal development of internal and external genitalia. Patients with DSD, particularly those with segments of the Y chromosome, are at increased risk for germ cell tumors including gonadoblastoma. Gonadoblastoma is a neoplasm comprised of a mixture of germ cells and elements resembling immature granulosa or Sertoli cells with or without Leydig cells or lutein-type cells in an ovarian type stroma. Read More

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http://journals.sagepub.com/doi/10.1177/1093526618824469
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http://dx.doi.org/10.1177/1093526618824469DOI Listing
January 2019
4 Reads
0.857 Impact Factor

Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases.

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

d Department of Internal Medicine (South), Faculty of Medicine , Universidad de Chile , Santiago , Chile.

Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549214DOI Listing
January 2019
2 Reads

Insulin-like factor 3, luteinizing hormone and testosterone in testicular cancer patients: effects of β-hCG and cancer treatment.

Andrology 2019 Jan 4. Epub 2019 Jan 4.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Primary hypogonadism (low testosterone and high luteinizing hormone, LH) is present in approximately 20% of testicular cancer (TC) survivors after orchidectomy with or without chemotherapy.

Objectives: We investigated insulin-like factor 3 (INSL3), a novel marker of Leydig cell function, in TC patients.

Materials And Methods: We analyzed: (I) a cross-sectional cohort of TC patients after orchidectomy with or without chemotherapy (1988-1999) at long-term follow-up (median 36 and 35 years of age at follow-up, respectively) and healthy men of similar age; (II) a longitudinal cohort of chemotherapy-treated TC patients (2000-2008), analyzed before and 1 year after chemotherapy (median 29 years of age at chemotherapy). Read More

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http://dx.doi.org/10.1111/andr.12581DOI Listing
January 2019

Characterization of Testicular Masses in Adults: Performance of Combined Quantitative Shear Wave Elastography and Conventional Ultrasound.

Ultrasound Med Biol 2019 Mar 29;45(3):720-731. Epub 2018 Dec 29.

Institut Langevin, ESPCI Paris, PSL Research University CNRS UMR 7587, INSERM ERL U-979, Paris, France; Department of Adult Radiology, Necker University Hospital, Paris, France; Paris Descartes University, Paris, France.

We prospectively evaluated the performance of combined shear wave elastography (SWE) and conventional ultrasound (US) for the characterization of 89 testicular focal masses. Testes were evaluated with B-mode, color Doppler and SWE measurements, locating a region of interest on the normal and pathologic parenchyma. Thirty-seven malignant tumors (MTs), 12 burned out tumors (BOTs), 28 Leydig cell tumors (LCTs), 2 dermoid cysts and other benign lesions were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03015629183048
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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.10.027DOI Listing
March 2019
1 Read

Steroidogenesis and VEGF Production Doesn't Alter in Leydig Cells within the Homeostatic Range of Testicular Temperature.

J Hum Reprod Sci 2018 Jul-Sep;11(3):291-296

Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, India.

Context: Physiologically defined homeostatic temperature range for human testis falls within 32°C-37°C and any deviation outside that range can result in impaired steroidogenesis. However, whether temperature deviation within the homeostatic range can affect the steroidogenesis, is still a question of the investigation.

Aim: In the present study, we investigated the production of progesterone, testosterone, and vascular endothelial growth factor (VEGF) within the homeostatic temperature range of testis, i. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_63_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262675PMC
December 2018

Ovarian steroid cell tumor, not otherwise specified.

Pathologica 2018 Sep;110(2):121-122

Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Sector-38, Gurgaon, Haryana 122 001, India.

Ovarian steroid cell tumours are rare virilizing tumours. They are three types of tumours of ovary which are characterized by steroid cell proliferation : Leydig cell tumour, steroid cell tumour, Not Otherwise Specified (NOS) and stromal luteoma. Here we present a case of 36 year old female, who presented with history of weight loss since last two and half months. Read More

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September 2018
10 Reads

Leydig cell tumor in an Amur tiger (Panthera tigris altaica).

J Vet Med Sci 2019 Feb 12;81(2):186-189. Epub 2018 Dec 12.

Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.

A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4. Read More

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https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_18
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http://dx.doi.org/10.1292/jvms.18-0573DOI Listing
February 2019
8 Reads

Cystic Anastomosing Hemangioma of the Ovary: A Case Report With Immunohistochemical and Ultrastructural Analysis.

Int J Surg Pathol 2018 Dec 6:1066896918817148. Epub 2018 Dec 6.

1 Istanbul University, Istanbul, Turkey.

In this article, we present a case of anastomosing hemangioma that shows cystic change. The tumor was a unilocular cystic lesion consisting of 2 distinct layers. The inner layer was composed of a proliferation of capillary-sized blood vessels resembling red pulp of the spleen. Read More

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http://dx.doi.org/10.1177/1066896918817148DOI Listing
December 2018
1 Read

Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.

Biomed Pharmacother 2019 Feb 5;110:409-419. Epub 2018 Dec 5.

Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519, Egypt. Electronic address:

Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.146DOI Listing
February 2019
1 Read
2.023 Impact Factor

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.

Authors:
Robert H Young

Arch Pathol Lab Med 2018 Dec;142(12):1459-1484

From the James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Context.—: This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-029
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http://dx.doi.org/10.5858/arpa.2018-0291-RADOI Listing
December 2018
14 Reads

A Contemporary Review of Common Adult Non-germ Cell Tumors of the Testis and Paratestis.

Surg Pathol Clin 2018 Dec 17;11(4):739-758. Epub 2018 Oct 17.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA. Electronic address:

This article provides a comprehensive review of non-germ cell tumors of the testis and paratestis in adults, incorporating the latest 2016 World Health Organization updates. Clinical features, gross pathologic findings, key morphologic details, immunohistochemical profiles, and differential diagnoses are covered, with an emphasis on how to resolve commonly encountered, and sometimes difficult, differential diagnoses. Read More

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http://dx.doi.org/10.1016/j.path.2018.07.002DOI Listing
December 2018
2 Reads

Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma.

Hum Pathol 2018 Nov 11. Epub 2018 Nov 11.

Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands.

Endometrioid endometrial carcinomas (EECs) are correlated with high serum levels of androgens and estrogen. We hypothesized that Leydig cells and ovarian stromal hyperplasia contribute to postmenopausal ovarian androgen production, and are observed more frequently in EEC patients. Ovaries of postmenopausal women with EEC (n=36) or non-endometrioid endometrial carcinoma (NEEC) (n=19) were examined for the presence of hilar Leydig cells, and compared with ovaries resected for benign conditions (n=22). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183041
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http://dx.doi.org/10.1016/j.humpath.2018.10.022DOI Listing
November 2018
12 Reads

Malignant ascites occurs most often in patients with high-grade serous papillary ovarian cancer at initial diagnosis: a retrospective analysis of 191 women treated at Bayreuth Hospital, 2006-2015.

Arch Gynecol Obstet 2019 Feb 10;299(2):515-523. Epub 2018 Nov 10.

Institute of Pathology, Klinikum Bayreuth, Preuschwitzer Strasse 101, 95445, Bayreuth, Germany.

Background: Malignant ascites often develops in patients with ovarian cancer, but there is a lack of more detailed characterization of the different histological subtypes.

Methods: Ascites specimens from patients with ovarian cancer who were treated at Bayreuth Hospital from 2006 to 2015, with follow-up until December 2016, were reevaluated retrospectively.

Results: A total of 191 women (mean age 64 years, range 48-79) were included, of whom 180 (94. Read More

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http://link.springer.com/10.1007/s00404-018-4952-9
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http://dx.doi.org/10.1007/s00404-018-4952-9DOI Listing
February 2019
14 Reads

Radiation effects on male fertility.

Andrology 2019 Jan 9;7(1):2-7. Epub 2018 Nov 9.

Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.

Background: Spermatogenesis is a process of dynamic cell differentiation. Ionizing radiation impairs spermatogenesis, and spermatogonia are more radiosensitive than spermatocytes or spermatids. Consistent with this assumption and due to improvement in tumor curability, nowadays, fertility preservation represents a public health need. Read More

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http://dx.doi.org/10.1111/andr.12562DOI Listing
January 2019

Virilising ovarian tumors: a single center experience.

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

N Shah, Mumbai, 400012, India.

Aims: Literature on virilising ovarian tumors (VOT) is limited to case reports and series reporting single pathological type. We have analyzed the clinical, hormonal, radiological, histological, management and outcome data of VOT.

Materials And Methods: This retrospective study was conducted at a tertiary health care center from Western India. Read More

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http://dx.doi.org/10.1530/EC-18-0360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280592PMC
November 2018
14 Reads

Rare case of occult testosterone-producing ovarian tumor that was diagnosed by selective venous hormone sampling.

Reprod Med Biol 2018 Oct 21;17(4):504-508. Epub 2018 Jun 21.

Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine Sapporo Japan.

Case: A 32 year old woman was referred because of secondary amenorrhea, hirsutism, and voice deepening.

Outcome: The blood testosterone level was markedly high. A transvaginal ultrasound revealed a small region in the left ovary, but whether or not it was a tumor was unclear. Read More

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http://dx.doi.org/10.1002/rmb2.12213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194242PMC
October 2018
2 Reads

Sertoli-Leydig cell tumors of ovary: A case series.

Medicine (Baltimore) 2018 Oct;97(42):e12865

Pathology Department, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.

Introduction: The purpose of this study was to report the clinical features, computed tomography (CT) and magnetic resonance imaging (MRI) findings, clinical management, and prognoses of 7 patients with Sertoli-Leydig cell tumors (SLCT) of ovary, and to review the literature of this rare condition.

Methods: Seven patients with pathologically confirmed ovarian SLCT were included. Their clinical, CT and MRI characteristics (CT images obtained from 6 patients and MR images from 4 patients), clinical management, and prognoses of 7 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000012865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211859PMC
October 2018
6 Reads

Prepubertal testicular tumors in China: a 10-year experience with 67 cases.

Pediatr Surg Int 2018 Dec 15;34(12):1339-1343. Epub 2018 Oct 15.

Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Aim: Prepubertal testicular tumors are rare in children. We aim to present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single medical center of China.

Materials And Methods: A total of 67 children (≤ 14 years) treated for testicular tumor at our institution from 2005 to 2015 were retrospectively reviewed. Read More

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http://link.springer.com/10.1007/s00383-018-4366-6
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http://dx.doi.org/10.1007/s00383-018-4366-6DOI Listing
December 2018
12 Reads

Identification of a Novel Zebrafish Mutant Line that Develops Testicular Germ Cell Tumors.

Zebrafish 2019 Feb 9;16(1):15-28. Epub 2018 Oct 9.

Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey.

Testicular tumors are the most common solid malignant tumors in men 20-35 years of age. Although most of testicular tumors are curable, current treatments still fail in 15%-20% of patients. However, insufficient understanding of the molecular basis and lack of animal models limit development of more effective treatments. Read More

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http://dx.doi.org/10.1089/zeb.2018.1604DOI Listing
February 2019
6 Reads

Ovarian tumors secreting androgens: an infrequent cause of hyperandrogenism.

Minerva Ginecol 2019 Feb 2;71(1):72-77. Epub 2018 Oct 2.

Argentine Society of Gynecological Endocrinology and Reproduction (SAEGRE), Buenos Aires, Argentina.

Background: The sex cord-stromal tumors are relative rare, comprising 5-8% of all ovarian neoplasms.

Methods: The study androgen tumors and a description of three cases: Leydig tumor, steroid cell (NOS) tumor and Sertoli-Leydig tumor.

Results: Twelve patients were menopausal and one patient of reproductive age. Read More

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https://www.minervamedica.it/index2.php?show=R09Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4784.18.04302-2DOI Listing
February 2019
4 Reads

Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells.

Cell Death Dis 2018 Sep 20;9(10):968. Epub 2018 Sep 20.

College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Diabetes mellitus affects a large number of men of reproductive age and it usually leads to serious reproductive disorders. However, the underlying mechanisms and specific therapies still remain largely unknown. We observed Leydig cell loss in the testes of diabetic mice. Read More

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http://dx.doi.org/10.1038/s41419-018-0956-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148071PMC
September 2018
1 Read

Results from a Monocentric Long-Term Analysis of 23 Patients with Ovarian Sertoli-Leydig Cell Tumors.

Oncologist 2018 Sep 10. Epub 2018 Sep 10.

Department of Gynecologic Surgery, Gustave Roussy, Villejuif, France.

Background: Sertoli-Leydig cell tumors (SLCTs) represent less than 0.5% of ovarian tumors. Because of the rarity of this tumor and its peak in frequency at around 25 years of age, this study aimed to describe SLCT management strategies. Read More

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http://dx.doi.org/10.1634/theoncologist.2017-0632DOI Listing
September 2018
10 Reads

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells.

Cancer Sci 2018 Nov 23;109(11):3503-3518. Epub 2018 Oct 23.

Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Fibroblast growth factor 9 (FGF9) promotes cancer progression; however, its role in cell proliferation related to tumorigenesis remains elusive. We investigated how FGF9 affected MA-10 mouse Leydig tumor cell proliferation and found that FGF9 significantly induced cell proliferation by activating ERK1/2 and retinoblastoma (Rb) phosphorylations within 15 minutes. Subsequently, the expressions of E2F1 and the cell cycle regulators: cyclin D1, cyclin E1 and cyclin-dependent kinase 4 (CDK4) in G phase and cyclin A1, CDK2 and CDK1 in S-G /M phases were increased at 12 hours after FGF9 treatment; and cyclin B1 in G /M phases were induced at 24 hours after FGF9 stimulation, whereas the phosphorylations of p53, p21 and p27 were not affected by FGF9. Read More

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http://doi.wiley.com/10.1111/cas.13793
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http://dx.doi.org/10.1111/cas.13793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215879PMC
November 2018
12 Reads

Transcriptome analysis to identify the Ras and Rap1 signal pathway genes involved in the response of TM3 Leydig cells exposed to zearalenone.

Environ Sci Pollut Res Int 2018 Nov 6;25(31):31230-31239. Epub 2018 Sep 6.

Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.

The mechanism of action of zearalenone (ZEA) in inducing germ cell tumors is unclear, and little is known about the change in the transcriptome of germ cells after ZEA exposure. To explore the molecular basis of the ZEA oncogene, we examined the median lethal concentration (50 μmol/L) and pro-apoptotic effect of ZEA on TM3 Leydig cells by MTT and TUNEL assay. Subsequently, we investigated the genetic changes in the transcriptome of TM3 Leydig cells exposed to 50 μmol/L ZEA. Read More

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http://link.springer.com/10.1007/s11356-018-3129-1
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http://dx.doi.org/10.1007/s11356-018-3129-1DOI Listing
November 2018
16 Reads

FEAT enhances INSL3 expression in testicular Leydig cells.

Genes Cells 2018 Nov 2;23(11):952-962. Epub 2018 Oct 2.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

FEAT, the protein encoded by methyltransferase-like 13 (METTL13), is aberrantly upregulated in most human cancers and potently drives tumorigenesis in vivo; however, its role in normal tissues remains elusive. Immunoblotting has displayed weak FEAT expression in normal human tissues, including the testis. Here, we found that FEAT is expressed in fetal and adult Leydig cells in the testis. Read More

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http://dx.doi.org/10.1111/gtc.12644DOI Listing
November 2018
7 Reads
2.810 Impact Factor

Modulation of the transcriptomic profile of the R2C tumor Leydig cell line by the adipose tissue derived hormone leptin.

Reprod Biol 2018 Dec 30;18(4):440-449. Epub 2018 Aug 30.

Biology Department, Université de Moncton, Moncton, New-Brunswick, E1A 3E9 Canada.

Leptin is an important adipose derived hormone being secreted by adipocytes and involved in appetite regulation. Disruption of normal plasma levels of leptin has been associated with the pathogenesis of obesity. It is now well established that obesity is associated to an increased risk of cancer development, including testicular cancers. Read More

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http://dx.doi.org/10.1016/j.repbio.2018.08.003DOI Listing
December 2018
12 Reads
1.524 Impact Factor

Frozen Section Diagnostic Pitfalls of Sertoli-Leydig Cell Tumor with Heterologous Elements.

Case Rep Pathol 2018 25;2018:5151082. Epub 2018 Jul 25.

Brooke Army Medical Center, San Antonio, TX, USA.

A woman in her sixth decade presented with several months of abdominal cramping, decreased appetite, bloating, and increased constipation. Radiologic imaging revealed a 28 cm, multilocular, heterogeneous cystic neoplasm involving the right adnexa. An intraoperative frozen section showed mucinous glandular epithelium, with and without foci of goblet cells, embedded in apparent ovarian stroma. Read More

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http://dx.doi.org/10.1155/2018/5151082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083536PMC
July 2018
13 Reads

Targeted Genomic Profiling of Female Adnexal Tumors of Probable Wolffian Origin (FATWO).

Int J Gynecol Pathol 2018 Aug 21. Epub 2018 Aug 21.

Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (J.M.) Department of Pathology (F.D., L.M.S., E.G., N.L.) Department of Pathology, Division of Women's and Perinatal Pathology (J.M., C.P.C., M.R.N., B.E.H.), Brigham and Women's Hospital Dana-Farber Cancer Institute (E.G., L.M.), Boston, Massachusetts Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK (W.G.M.) Department of Pathology, Stanford University School of Medicine, Stanford, California (B.E.H.).

Female adnexal tumor of probable Wolffian origin (FATWO) is a rare gynecologic neoplasm of low-malignant potential presumed to be derived from mesonephric remnants in the upper female genital tract. Similarly, mesonephric remnants in the lower female genital tract are thought to be the origin for mesonephric carcinoma. Although the molecular alterations in mesonephric carcinoma have been recently reported, the pathogenesis of and molecular alterations in FATWO are not well understood. Read More

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http://Insights.ovid.com/crossref?an=00004347-900000000-9915
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http://dx.doi.org/10.1097/PGP.0000000000000545DOI Listing
August 2018
18 Reads

Two Years of Gynecomastia Caused by Leydig Cell Tumor.

Case Rep Urol 2018 19;2018:7202560. Epub 2018 Jul 19.

Department of Urology and Pediatric Urology, Saarland University, Homburg/Saar, Germany.

Gynecomastia is a common incidental finding in males that can be caused by various benign or malignant diseases. In rare cases, it results from Leydig cell tumors, a rare entity accounting for 3% of all testicular neoplasms. Some of them are hormonally active but seldom cause symptomatic endocrine disturbance. Read More

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https://www.hindawi.com/journals/criu/2018/7202560/
Publisher Site
http://dx.doi.org/10.1155/2018/7202560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077527PMC
July 2018
6 Reads

Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility.

Front Endocrinol (Lausanne) 2018 23;9:401. Epub 2018 Jul 23.

School of Biosciences and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, United Kingdom.

Nonsyndromic cryptorchidism is a common multifactorial, condition with long-term risks of subfertility and testicular cancer. Revealing the causes of cryptorchidism will likely improve prediction and prevention of adverse outcomes. Herein we provide our current perspective of cryptorchidism complexity in a synthesis of cumulative clinical and translational data generated by ourselves and others. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00401
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http://dx.doi.org/10.3389/fendo.2018.00401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065160PMC
July 2018
5 Reads

Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell tumors.

Pathol Res Pract 2018 Sep 21;214(9):1370-1375. Epub 2018 Feb 21.

Department of Pathology, Peking University, People's Hospital, Beijing, 100044, China.

Background: To evaluate the clinicopathological and histopathological characteristics of ovarian Sertoli-Leydig cell tumors (SLCTs) in relation to differential diagnosis, and patient prognosis.

Methods: A review of clinical data, pathological morphology and immunohistochemical analysis of SLCTs were performed in 18 SLCTs patients. The DICER1 gene mutation was assessed in eight cases that were obtained from in-house surgical resections. Read More

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http://dx.doi.org/10.1016/j.prp.2018.02.018DOI Listing
September 2018
2 Reads

Diagnostic Dilemma in Two Cases of Hyperandrogenism.

Case Rep Endocrinol 2018 27;2018:9041018. Epub 2018 Jun 27.

Endocrinology Department, Al-Assad University Hospital, Damascus University, Syria.

Hirsutism is a common endocrine complaint affecting about 10 percent of women. It may be caused by multiple etiologies including adrenal and ovarian disorders. Usually, it is a result of a benign entity such as PCOs and idiopathic hirsutism. Read More

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http://dx.doi.org/10.1155/2018/9041018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040299PMC
June 2018
3 Reads

Ovarian Sertoli-Leydig tumor after bone marrow transplant for sickle cell disease.

Pediatr Blood Cancer 2018 Nov 24;65(11):e27367. Epub 2018 Jul 24.

Pediatric Hematology/Oncology and Bone Marrow Transplant, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.

As bone marrow transplant for sickle cell disease becomes increasingly common, long-term outcomes including secondary malignancies are beginning to be described. Here, we report a case of ovarian Sertoli-Leydig tumor that occurred after allogeneic bone marrow transplant for sickle cell disease. Read More

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http://dx.doi.org/10.1002/pbc.27367DOI Listing
November 2018

Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome.

Gynecol Oncol Rep 2018 Aug 15;25:94-97. Epub 2018 Jun 15.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL, USA.

•Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with mutation•-associated tumors should prompt genetic counseling and testing•Somatic and germline genetic mutation profiles can be used to differentiate second primary from recurrent tumors. Read More

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http://dx.doi.org/10.1016/j.gore.2018.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019406PMC

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review.

J Pathol Transl Med 2018 Sep 17;52(5):344-348. Epub 2018 Jul 17.

Department of Pathology, Yeungnam University School of Medicine, Daegu, Korea.

Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children and adolescents. A 71-year-old woman with right upper quadrant abdominal pain visited our hospital. Read More

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http://dx.doi.org/10.4132/jptm.2018.06.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166011PMC
September 2018
5 Reads

[Pathologic features on gonadal changes of sexual developmental disorders in children].

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):531-535

Department of Pediatric Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.07.010DOI Listing
July 2018
20 Reads

Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?

Int J Biol Sci 2018 13;14(9):1109-1121. Epub 2018 Jun 13.

Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.

We used chronic restraint-induced stress (CRIS) and iron ionizing radiation (IR) to mimic human exposure to psychological stress (PS) and IR in a mouse model, and to investigate the relationship among endoplasmic reticulum stress (ERS), apoptosis and autophagy in testicular toxicity. Male C57BL/6N mice were restrained for 6 h/day for 28 consecutive days, and total body irradiation with 0.1 or 2 Gy iron ion beam was performed on the day 8. Read More

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http://dx.doi.org/10.7150/ijbs.22805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036728PMC
June 2018
7 Reads

Mechanisms of Yangjing Capsule in Leydig Cell Apoptosis and Testosterone Synthesis via Promoting StAR Expression.

Biol Pharm Bull 2018 Sep 6;41(9):1401-1405. Epub 2018 Jul 6.

Medical College of Qinghai University.

The present study aims to investigate the roles of steroidogenic acute regulatory protein (StAR) in Yangjing Capsule (YC) induced anti-apoptotic effects on Leydig cells and the related mechanism. Leydig tumor cells (MLTC-1) were cultured and treated with YC, and immunofluorescence assay was performed to examine the expression of StAR; furthermore, luciferase reporter assay was conducted to evaluate the impact of YC on StAR promoter; next, MLTC-1 cells were treated with StAR small interfering RNA (siRNA), and flow cytometry was carried out to examine the effect of StAR siRNA on the apoptosis of the cells; furthermore, quantitative (q)RT-PCR and Western blot methods was used to determine the expression of StAR and apoptosis related molecules Bcl-2, Bax and Caspase-3 on both mRNA and protein levels in different groups; finally the secretion of testosterone in different groups was examined by radioimmunoassay. We observed that the YC can increase the expression of StAR in a dose-dependent manner, and YC can activate the promoter of StAR; moreover, transfection of StAR siRNA can block YC induced anti-apoptotic effects and increased production of testosterone. Read More

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http://dx.doi.org/10.1248/bpb.b18-00205DOI Listing
September 2018
5 Reads

Management of testicular Leydig cell tumor: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11158

Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University.

Rationale: Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000011158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023788PMC
June 2018
11 Reads

Poorly differentiated, ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcoma and glandular elements: Diagnosis and management of a rare neoplasm.

Gynecol Oncol Rep 2018 Aug 12;25:70-73. Epub 2018 Jun 12.

Department of Gynecologic Oncology, Florida Hospital, Orlando, FL 32804, USA.

Ovarian Sertoli-Leydig cell tumors (SLCT) represent <2% of primary ovarian tumors, which range from benign to malignant; majority of the latter are low-grade. We present the case of a 12-year-old pre-pubertal female with poorly differentiated SLCT and heterologous rhabdomyosarcoma (FIGO stage-IA). She presented with worsening abdominal pain, pelvic mass, and elevated pre-operative serum Alpha-fetoprotein (AFP, 77. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23525789183005
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http://dx.doi.org/10.1016/j.gore.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005800PMC
August 2018
6 Reads

Insights into the role of estrogen-related receptors α, β and γ in tumor Leydig cells.

Tissue Cell 2018 Jun 13;52:78-91. Epub 2018 Apr 13.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387, Krakow, Poland.

In this study, we demonstrate, for the first time, estrogen-related receptor (ERR) regulation of the physiological and biochemical status of testicular tumor Leydig cells. In a mouse tumor Leydig cells, ERRs (α, β, and γ) were silenced via siRNA. Cell morphology and cell physiology (proliferation and observation of monolayer formation) were performed by inverted phase-contrast microscope. Read More

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http://dx.doi.org/10.1016/j.tice.2018.04.003DOI Listing
June 2018
8 Reads

Extensive Bilateral Adrenal Rest Testicular Tumors in a Patient With 3-Hydroxysteroid Dehydrogenase Type 2 Deficiency.

J Endocr Soc 2018 Jun 1;2(6):513-517. Epub 2018 May 1.

Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.

Testicular adrenal rest tumors (TARTs) are presumably derived from ectopic adrenocortical tissue in the testis, affecting up to 49% to 94% of males with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Few reports have described TARTs in rarer forms of CAH such as 3-hydroxysteroid dehydrogenase type 2 deficiency (3HSD2D). A man with 3HSD2D presented with massive bilateral testicular tumors. Read More

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http://dx.doi.org/10.1210/js.2018-00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961024PMC
June 2018
5 Reads

Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis.

Arch Toxicol 2018 Jun 2;92(6):2013-2025. Epub 2018 May 2.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Read More

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http://link.springer.com/10.1007/s00204-018-2207-y
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http://dx.doi.org/10.1007/s00204-018-2207-yDOI Listing
June 2018
9 Reads

Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review.

Oncotarget 2018 Apr 10;9(27):19415-19426. Epub 2018 Apr 10.

University of Catania, Department of Medical, Surgical and Advanced Technologies, "G.F. Ingrassia", Catania, Italy.

Anabolic androgenic steroids (AAS) are some of the most common drugs used among athletes, frequently in combination with resistance training, to improve physical performance or for aesthetic purpose. A great number of scientific reports showed the detrimental effects of anabolic androgenic steroids on different organs and tissues. In this literature review, we analyzed the AAS-mediated carcinogenicity, focusing on Leydig cell tumor. Read More

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http://dx.doi.org/10.18632/oncotarget.24767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922407PMC
April 2018
1 Read

Contribution of lymph node staging method and prognostic factors in malignant ovarian sex cord-stromal tumors: A world wide database analysis.

Eur J Surg Oncol 2018 07 6;44(7):1054-1061. Epub 2018 Apr 6.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200032, China; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease of Fudan University, Shanghai, 200011, China. Electronic address:

Objective: To investigate the clinicopathologic prognostic factors in patients with malignant sex cord-stromal tumors (SCSTs) with lymph node dissection, and at the same time, to evaluate the influence of the log odds of positive lymph nodes (LODDS) on their survival.

Methods: Patients diagnosed with malignant SCSTs who underwent lymph node dissection were extracted from the 1988-2013 Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and cancer-specific survival (CSS) were estimated by Kaplan-Meier curves. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183099
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http://dx.doi.org/10.1016/j.ejso.2018.03.027DOI Listing
July 2018
6 Reads