3,983 results match your criteria Leydig Cell Tumors


Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features.

Mod Pathol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Testicular Leydig cell tumor (LCT), the most common sex-cord stromal tumor in men, represents a small fraction of all testicular tumors (~1 to 3%). Although most testicular LCTs are indolent and cured by radical orchiectomy, 5-10% have aggressive biology and metastatic potential. In primary LCTs, large size, cytologic atypia, necrosis, increased mitotic activity, and vascular invasion have been associated with clinically aggressive tumors. Read More

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Adrenal Rests in the Uro-genital Tract of an Adult Population.

Endocr Pathol 2021 Jun 7. Epub 2021 Jun 7.

Pathology Unit, Department of Oncology, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.

Ectopic adrenal rests are a rare condition which can be found in various sites, generally in the retroperitoneum or pelvis along the path of gonadal descent. Their real prevalence is unknown. Males are more commonly affected, at least in the pediatric age. Read More

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Hyperandrogenism, oligomenorrhea, and erythrocytosis caused by an ovarian Leydig cell tumor: A case report.

Clin Case Rep 2021 May 26;9(5):e04001. Epub 2021 Mar 26.

Serviço de Endocrinologia Diabetes e Metabolismo Centro Hospitalar e Universitário de S. João Porto Portugal.

Leydig cell tumors are rare ovarian neoplasms. Affected individuals typically present with amenorrhea/oligomenorrhea and rapidly progressive features of virilization. Erythrocytosis can also occur as a result of high testosterone levels. Read More

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A single-center retrospective long-term analysis of 80 cases of ovarian Sertoli-Leydig cell tumors.

Chin Med J (Engl) 2021 May 13. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

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Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

CNRS, INRAe, Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France.

In contrast to all transmembrane adenylyl cyclases except ADCY9, the cytosolic soluble adenylyl cyclase (ADCY10) is insensitive to forskolin stimulation and is uniquely modulated by calcium and bicarbonate ions. In the present paper, we focus on ADCY10 localization and a kinetic analysis of intracellular cAMP accumulation in response to human LH in the absence or presence of four different ADCY10 inhibitors (KH7, LRE1, 2-CE and 4-CE) in MTLC-1 cells. ADCY10 was immuno-detected in the cytoplasm of MLTC-1 cells and all four inhibitors were found to inhibit LH-stimulated cAMP accumulation and progesterone level in MLTC-1 and testosterone level primary Leydig cells. Read More

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Spectrum of Germline Pathogenic Variants in Ovarian Sertoli-Leydig Cell Tumor.

J Clin Med 2021 Apr 23;10(9). Epub 2021 Apr 23.

Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.

Sertoli-Leydig Cell Tumors (SLCTs) are rare ovarian sex cord-stromal neoplasms, which predominantly affect adolescents and young female adults. The SLCTs clinical diagnosis and treatment remains challenging due to the rarity and the varied presentation. A large majority of SLCTs are unilateral, but also bilateral neoplasms have been reported, sometimes in the context of syndrome. Read More

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Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.

Asian J Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Testis-sparing surgery (TSS) has been increasingly used for treating a variety of testicular tumors (TTs) in children. However, the indications and feasibility associated with TSS remain uncertain. This study aimed to present the clinical outcomes of TSS in children with TTs. Read More

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Immunohistochemical Detection of Cancer-Testis Antigen PRAME.

Int J Surg Pathol 2021 Apr 23:10668969211012085. Epub 2021 Apr 23.

5803Memorial Sloan-Kettering Cancer Center, New York, USA.

Cancer-testis (CT) antigens were identified by their ability to elicit T- or B-cell immune responses in the autologous host. They are typically expressed in a wide variety of neoplasms and in normal adult tissues are restricted to testicular germ cells. PReferentially expressed Antigen of Melanoma (PRAME) is a member of the family of nonclassical CT antigens being expressed in a few other normal tissues besides testis. Read More

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Primary Biphasic Hepatic Sarcoma in DICER1 Syndrome.

Pediatr Dev Pathol 2021 Apr 19:10935266211008443. Epub 2021 Apr 19.

Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

DICER1 tumor predisposition syndrome is a rare genetic disorder that predisposes individuals to multiple benign and malignant neoplasms. The phenotype is vast and includes pleuropulmonary blastoma (PPB), thyroid nodules, cystic nephroma, Wilms tumor, ovarian Sertoli-Leydig cell tumor, and medulloepithelioma, among others. Herein, we describe a patient with a germline pathogenic variant presenting with two neoplasms that are not commonly encountered in the context of DICER1 syndrome. Read More

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Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Adv Anat Pathol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Testicular tumors are incredibly diverse and one of the most challenging areas in surgical pathology. Because of the rarity and overlapping features with numerous entities occurring in the testis and paratestis, these tumors pose a diagnostic challenge even to the most experienced general pathologists. In 2016, the latest "World Health Organization (WHO) classification of testicular tumors" was released, which incorporated several updates to the previous 2004 classification system. Read More

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Leydig Cell Tumor in a Patient with 46,XX Disorder of Sex Development (DSD), Ovotesticular: A Case Report and a Review of the Literature.

Case Rep Pathol 2021 29;2021:5552305. Epub 2021 Mar 29.

Dr. Senckenberg Institute of Pathology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.

Disorder of sex development (DSD) is a rare condition with atypical development of chromosomal, gonadal, or anatomical sex. It is classified in different subgroups based on the patient's karyotype, gonadal dysgenesis, and the appearance of the internal and external genitalia. Within the subgroups, the risk for developing neoplasms varies a lot. Read More

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Bilateral Ovarian Leydig Cell Tumors in a Postmenopausal Woman Causing Hirsutism and Virilization.

AACE Clin Case Rep 2021 Jan-Feb;7(1):26-28. Epub 2020 Dec 28.

Division of Endocrinology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Objective: To evaluate a rare case of a postmenopausal woman with hirsutism and virilization due to Leydig cell tumors (LCTs) of both ovaries.

Methods: In this challenging case, the diagnostic studies included the detection of total/free testosterone, hemoglobin, and estradiol levels; adrenal computed tomography; and pelvic magnetic resonance imaging.

Results: A 61-year-old woman presented for the evaluation of hirsutism. Read More

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December 2020

Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors.

Sci Prog 2021 Apr-Jun;104(2):368504211009668

Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

To explore the clinical features, imaging findings, and pathological manifestations of ovarian Sertoli-Leydig cell tumors (SLCTs). The clinical and pathological manifestations, tumor location, size, morphology, vascularity, computed tomography (CT) density, magnetic resonance imaging (MRI) signal intensity, and contrast enhancement patterns in five cases with SLCTs were retrospectively reviewed. SLCTs most commonly occurred in young women. Read More

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Testicular Adrenal Rest Tumors or Bilateral Leydig Cell Tumors?

Urology 2021 Apr 3. Epub 2021 Apr 3.

Advanced Urology and West Virginia School of Osteopathic Medicine, 1717 Harper Road, Third Floor, Suite A, Beckley, WV 25801.

Testicular Adrenal Rest Tumors, also known as Testicular Tumors of the Androgenital Syndrome, are benign tumors found in the testes of patients with congenital adrenal hyperplasia. While considered benign, they are significant in that they can proliferate within the rete testis and cause infertility. We present a patient who appeared to have findings consistent with testicular adrenal rest tumors and is in the process of malignancy rule out. Read More

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Dynamic Remodeling of Membranes and Their Lipids during Acute Hormone-Induced Steroidogenesis in MA-10 Mouse Leydig Tumor Cells.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

The Research Institute, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Lipids play essential roles in numerous cellular processes, including membrane remodeling, signal transduction, the modulation of hormone activity, and steroidogenesis. We chose steroidogenic MA-10 mouse tumor Leydig cells to investigate subcellular lipid localization during steroidogenesis. Electron microscopy showed that cAMP stimulation increased associations between the plasma membrane (PM) and the endoplasmic reticulum (ER) and between the ER and mitochondria. Read More

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Clinicopathological analysis of ovarian sertoli-leydig cell tumor with postmenopausal vaginal bleeding as the first symptom: A case report.

Medicine (Baltimore) 2021 Apr;100(13):e24922

Department of Obsterics and Gynecology, Hubei Maternal and Child Health Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, China.

Rational: Ovarian sertoli-leydig cell tumor (OSLCT) is extremely rare. We reported a OSLCT case in whom postmenopausal vaginal bleeding was the first symptom.

Patient Concerns: The patient came to our hospital due to postmenopausal vaginal bleeding. Read More

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Comparison of the Prognostic Outcome between High-Grade Ovarian Sertoli-Leydig Cell Tumors (SLCTs) and Low-Grade SLCTs.

Yonsei Med J 2021 Apr;62(4):366-369

Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.

The purpose of the current study was to compare prognostic outcomes between patients with high-grade ovarian Sertoli-Leydig cell tumors (SLCTs) and those with other low-grade SLCTs. We retrospectively reviewed medical records for 24 patients pathologically diagnosed with SLCTs between 2006 to 2019 at two institutions. The patients were grouped according to pathological grade: SLCT was classified as grade 1, well differentiated; grade 2, intermediated differentiated; or grade 3, poorly differentiated (Meyer's classification). Read More

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Unusual clinical scenarios in Urology and Andrology.

Arch Ital Urol Androl 2021 Mar 22;93(1):120-126. Epub 2021 Mar 22.

Division of Urology, University Hospital "Ospedali Riuniti", School of Medicine, Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, Ancona.

This collection includes some unusual cases and how they were diagnosed and treated. Case 1: A case of a patient with primary hyperthyroidism presenting with a submucosal ureteral stone after endoscopic lithotripsy was described. After multiple endoscopic treatment, the stone was successfully removed by open ureterolithotomy recovering ureteral patency and normal renal function. Read More

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TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors.

Clin Genitourin Cancer 2021 Feb 18. Epub 2021 Feb 18.

Caris Life Sciences, Phoenix, Arizona.

Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult-to-treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic profiling for detection of therapeutic targets, which was then followed by an investigation into a cohort of additional LCTs.

Patients And Methods: Twenty-nine LCT (27 male and 2 female patients) were profiled using next-generation sequencing and immunohistochemistry. Read More

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February 2021

Ovarian Leydig cell tumor and postmenopausal hirsutism with signs of virilisation.

BMJ Case Rep 2021 Mar 17;14(3). Epub 2021 Mar 17.

Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.

A 71-year-old woman was referred to the endocrinology clinic to investigate postmenopausal hirsutism with 10 years of evolution. She had history of regular menses and menopause with 50 years old. Physical examination showed a male pattern facies, deepening of the voice, androgenic alopecia and hirsutism with a score of 23 according to the modified Ferriman-Gallwey scale. Read More

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Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors.

Tissue Cell 2021 Feb 26;71:101513. Epub 2021 Feb 26.

Department of Histology and Embryology, Ankara Yıldırım Beyazıt University, Ankara, Turkey. Electronic address:

Ubiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Beclin 1) proteins in human testicular tumors and cancer adjacent normal testicular tissues. Read More

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February 2021

Role of Constitutive STAR in Leydig Cells.

Int J Mol Sci 2021 Feb 18;22(4). Epub 2021 Feb 18.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

Leydig cells contain significant amounts of constitutively produced steroidogenic acute regulatory protein (STAR; STARD1). Hormone-induced STAR plays an essential role in inducing the transfer of cholesterol into the mitochondria for hormone-dependent steroidogenesis. STAR acts at the outer mitochondrial membrane, where it interacts with a protein complex, which includes the translocator protein (TSPO). Read More

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February 2021

Detection of pure Leydig cell ovarian tumor not visible on imaging by selective venous blood sampling in a woman with secondary amenorrhea and hirsutism: A case report.

Case Rep Womens Health 2021 Apr 11;30:e00298. Epub 2021 Feb 11.

Department of Obstetrics and Gynecology, School of Medicine, Shimane University, 89-1 Enya Cho, Izumo, Shimane 693-8501, Japan.

A 39-year-old woman (gravida 1, para 1) was referred to a university hospital with a high serum testosterone level and secondary amenorrhea, hirsutism, and weight gain. Her voice was deep, and hirsutism was observed on her chin, arms, and back. She also had clitoromegaly. Read More

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In vitro effects of the endocrine disruptor p,p'DDT on human choriogonadotropin/luteinizing hormone receptor signalling.

Arch Toxicol 2021 05 27;95(5):1671-1681. Epub 2021 Feb 27.

UMR CNRS 6015, INSERM 1083, 3 Rue Roger Amsler - Angers University, 49000, Angers, France.

Dichlorodiphenyltrichloroethane (p,p'DDT) is an endocrine-disrupting chemical (EDC). Several studies showed an association between p,p'DDT exposure and reprotoxic effects. We showed that p,p'DDT was a positive allosteric modulator of human follitropin receptor (FSHR). Read More

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[Leydig Cell Tumor in a Patient with Contralateral Cryptorchidism: A Rare Association].

Acta Med Port 2021 Feb 22;34(2):137-139. Epub 2020 Sep 22.

Unidade de Saúde Familiar do Dafundo. Lisboa. Portugal.

Gynecomastia is a frequent sign that may be physiological or caused by various benign or malignant diseases. In rare cases, it may be caused by testicular tumors. We describe a case of progressive gynecomastia at age 20 due to a Leydig cell tumor of the right testicle in a patient with a previous history of left-sided cryptorchidism. Read More

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February 2021

A Genome-First Approach to Characterize DICER1 Pathogenic Variant Prevalence, Penetrance, and Phenotype.

JAMA Netw Open 2021 02 1;4(2):e210112. Epub 2021 Feb 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Importance: Genetic disorders are historically defined through phenotype-first approaches. However, risk estimates derived from phenotype-linked ascertainment may overestimate severity and penetrance. Pathogenic variants in DICER1 are associated with increased risks of rare and common neoplasms and thyroid disease in adults and children. Read More

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February 2021

Background data of 2-year-old male and female F344 delta rats.

J Toxicol Pathol 2021 Jan 3;34(1):23-31. Epub 2020 Oct 3.

Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.

Although delta rats, as reporter gene-transgenic rats, were originally developed for mutation assays, they have also been used to evaluate chemical carcinogenesis and comprehensive toxicity. Therefore, it is necessary to accumulate background data on carcinogenicity and general toxicity in delta rats. Here, we investigated the background data of 110-week-old male and female F344 delta rats and wild-type rats. Read More

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January 2021

The role of FOXL2, SOX9, and β-catenin expression and DICER1 mutation in differentiating sex cord tumor with annular tubules from other sex cord tumors of the ovary.

Virchows Arch 2021 Feb 10. Epub 2021 Feb 10.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093, Istanbul, Turkey.

Sex cord tumor with annular tubules (SCTAT) is a highly rare type of ovarian sex cord-stromal tumor (SCST), the diagnosis of which remains to be challenging. The aim of this study was to scrutinize the utility of three immunohistochemical markers including Forkhead box protein 2 (FOXL2), SOX9, and β-catenin and DICER1 mutation status in distinguishing SCTATs from other ovarian SCSTs. Nine cases of SCTAT, 10 Sertoli-Leydig cell tumor (SCLT), 10 adult-type granulosa cell tumor (AGCT), and 8 juvenile-type granulosa cell tumor (JGCT) were included in the study. Read More

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February 2021

Cellular Expression and Subcellular Localization of Wwox Protein During Testicular Development and Spermatogenesis in Rats.

J Histochem Cytochem 2021 Apr 10;69(4):257-270. Epub 2021 Feb 10.

Laboratory of Veterinary Physiology, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.

A well-known putative tumor suppressor WW domain-containing oxidoreductase (Wwox) is highly expressed in hormonally regulated tissues and is considered important for the normal development and function of reproductive organs. In this study, we investigated the cellular and subcellular localization of Wwox in normal testes during postnatal days 0-70 using Western blotting and immunohistochemistry. Wwox is expressed in testes at all ages. Read More

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Sex Cord Stromal Tumors in Children and Adolescents: A First Report by The South African Children's Cancer Study Group (1990-2015).

J Pediatr Hematol Oncol 2021 Feb 3. Epub 2021 Feb 3.

Department of Paediatrics and Child Health, Haematology-Oncology Service, Red Cross War Memorial Children's Hospital Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town Burden of Disease Research Unit, South African Medical Research Council Division of Paediatric Haematology-Oncology, Department of Paediatrics and Child Health, Tygerberg Hospital, Faculty of Medicine and Health Sciences, University of Stellenbosch Neurodevelopmental Service, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town Division of Paediatric Haematology-Oncology, Department of Paediatrics and Child Health, Charlotte Maxeke Johannesburg Academic Hospital, University of Witwatersrand, Johannesburg Division of Pediatric Haematology-Oncology, Department of Paediatrics and Child Health, Pietermaritzburg Metropolitan Hospital Complex, University of KwaZulu-Natal, Pietermaritzburg Division of Paediatric Haematology-Oncology, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Soweto, Gauteng Division of Paediatric Haematology-Oncology, Department of Paediatrics, Universitas Hospital, University of the Free State, Bloemfontein Division of Paediatric Haematology-Oncology, Department of Paediatrics, Steve Biko Academic Hospital, University of Pretoria, Tshwane Division of Paediatric Haematology-Oncology, Department of Paediatrics and Child Health, Frere Hospital, East London Division of Paediatric Haematology-Oncology, Department of Paediatrics and Child Health, Port Elizabeth Provincial Hospital, Walter Sisulu University, Port Elizabeth, South Africa Paediatric Haematology and Oncology, Department of Paediatrics and Child Health, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium.

Objectives: Pediatric sex cord stromal tumors (SCSTs) are extremely rare and there are no reported data from Africa. The authors evaluated the outcomes of children and adolescents with biopsy-proven SCSTs in preparation for the introduction of a national protocol.

Materials And Methods: Retrospective data were collated from 9 South African pediatric oncology units from January 1990 to December 2015. Read More

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February 2021