3,895 results match your criteria Leydig Cell Tumors


A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer.

Urol Ann 2020 Apr-Jun;12(2):180-183. Epub 2020 Apr 14.

Department of Urology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

We describe a patient with a testosterone-producing metastasis discovered during the follow-up of prostate cancer. The patient had a history of a Leydig cell tumor (LCT) in the right testicle for which he underwent radical orchiectomy at the age of 60 years. Within a year after orchiectomy, he was diagnosed with prostate cancer. Read More

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http://dx.doi.org/10.4103/UA.UA_38_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292439PMC

Clinical Characteristics and Mutation Analysis of Ovarian Sertoli-Leydig Cell Tumors.

Oncologist 2020 Jun 17. Epub 2020 Jun 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Background: There are not many studies on Sertoli-Leydig cell tumors (SLCTs) and no data in the population of Chinese patients with SLCTs from the genetic level. In addition, most studies have explored only the DICER1 gene in SLCT; no clear idea exists of the genetic landscape of SLCT.

Methods: Patients who underwent surgical resection between January 2012 and October 2018 in our institution were recruited. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0110DOI Listing

Toxicological Effects of Cadmium on Mammalian Testis.

Front Genet 2020 26;11:527. Epub 2020 May 26.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis. In this review, we summarize the effects of cadmium on the development and function of the testis. Read More

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http://dx.doi.org/10.3389/fgene.2020.00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265816PMC

Ovarian Sertoli-Leydig and granulosa cell tumor: comparison of epidemiology and survival outcomes.

Arch Gynecol Obstet 2020 Aug 9;302(2):481-486. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Helen O'Dickens Women's Health Center, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.

Purpose: To investigate the epidemiology, clinico-pathological characteristics and outcomes of patients diagnosed with malignant ovarian Sertoli-Leydig cell tumors (SLCTs) in comparison to granulosa cell tumors (GCTs).

Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were accessed and patients diagnosed with a malignant SLCT and GCT between 1988 and 2013 were selected. Demographic and clinico-pathological characteristics were compared using the Mann-Whitney and chi-square tests. Read More

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http://dx.doi.org/10.1007/s00404-020-05633-zDOI Listing

Interstitial Leydig Cell Tumorigenesis-Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis.

Int J Mol Sci 2020 May 21;21(10). Epub 2020 May 21.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Krakow, Poland.

Although epidemiological studies from the last years report an increase in the incidences of Leydig cell tumors (previously thought to be a rare disease), the biochemical characteristics of that tumor important for understanding its etiology, diagnosis, and therapy still remains not completely characterized. Our prior studies reported G-protein coupled estrogen receptor signaling and estrogen level disturbances in Leydig cell tumors. In addition, we found that expressions of multi-level-acting lipid balance- and steroidogenesis-controlling proteins including peroxisome proliferator-activated receptor are altered in this tumor. Read More

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http://dx.doi.org/10.3390/ijms21103649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279359PMC

Ovarian Sertoli-Leydig cell tumors: an analysis of 13 cases.

Arch Gynecol Obstet 2020 Jul 19;302(1):203-208. Epub 2020 May 19.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: To report the clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients with Sertoli-Leydig cell tumors (SLCTs) of ovary.

Methods: 13 patients with pathologically confirmed ovarian SLCTs at International Peace Maternity and Child Health Hospital from 2010 and 2019 were included in this study. The clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00404-020-05588-1DOI Listing

Hyperglycemia contributes to the development of Leydig cell hyperplasia in male Spontaneously Diabetic Torii rats.

J Toxicol Pathol 2020 Apr 20;33(2):121-129. Epub 2020 Mar 20.

Laboratory of Molecular Pathophysiology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

Spontaneously Diabetic Torii (SDT) rats are a well-known animal model of non-obese type 2 diabetes mellitus. Although this animal model has been studied extensively over the last decade, the incidence rates of Leydig cell hyperplasia and tumors in this model have not been reported. In this study, pathophysiological analyses of the testes were performed on male SDT rats, to understand the effect of insulin treatment on the development of Leydig cell hyperplasia and tumors and the expression of integrins and extracellular matrix proteins. Read More

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http://dx.doi.org/10.1293/tox.2019-0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218238PMC

Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.

Mod Pathol 2020 May 15. Epub 2020 May 15.

International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN, USA.

Since the original description of pathogenic germline DICER1 variation underlying pleuropulmonary blastoma (PPB), the spectrum of extrapulmonary neoplasms known to be associated with DICER1 has continued to expand and now includes tumors of the ovary, thyroid, kidney, eye, and brain among other sites. This report documents our experience with another manifestation: a primitive sarcoma that resembles PPB and DICER1-associated sarcoma of the kidney. These tumors are distinguished by their unusual location in the peritoneal cavity, associated with visceral and/or parietal mesothelium. Read More

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http://dx.doi.org/10.1038/s41379-020-0558-4DOI Listing

[Ovarian Sertoli-Leydig cell tumors: DICER1 hotspot mutations and associated clinicopathological features].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):441-447

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumor (SLCT) and its associated clinicopathological features. Forty-three SLCTs and 40 other sex cord-stromal tumors (SCSTs) diagnosed between 2010 and 2017 at Fudan University Shanghai Cancer Center were examined for somatic DICER1 hotspot mutations by Sanger sequencing. The associations between mutation status and clinicopathological features, including patient age, tumor differentiation and recurrence, were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190826-00466DOI Listing

Diagnosis of a small Leydig cell tumor by dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging.

Radiol Case Rep 2020 Jul 1;15(7):875-878. Epub 2020 May 1.

Department of Radiology, Shimane University Faculty of Medicine, P.O. Box 00693-8501, 89-1 Enya Izumo, Japan.

Leydig cell tumors are usually small and resemble normal ovarian stroma, so they are often difficult to localize. Here, we present a rare case in 39-year-old woman which dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging findings showed some differences between a Leydig cell tumor and normal ovarian stroma. Combining these 2 MRI techniques may be useful for diagnosing a Leydig cell tumor. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200933PMC

Bilateral Leydig Cell Tumors in Klinefelter Patient: A Case Report.

Urology 2020 Apr 17. Epub 2020 Apr 17.

Indiana University School of Medicine, Department of Urology, Indianapolis, IN.

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http://dx.doi.org/10.1016/j.urology.2020.03.051DOI Listing

A comparison of stage-specific all-cause mortality between testicular sex cord stromal tumors and germ cell tumors: results from the National Cancer Database.

BMC Urol 2020 Apr 17;20(1):40. Epub 2020 Apr 17.

Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA, 94158, USA.

Background: Testicular sex cord stromal tumors (SCSTs) are managed similarly to germ cell tumors (GCTs); however, few studies have directly compared outcomes between these tumor types. Using the National Cancer Database (NCDB), we sought to compare overall and stage-specific all-cause mortality (ACM) between SCSTs versus GCTs.

Methods: NCDB was queried for patients diagnosed with SCSTs and GCTs between 2004 and 2013. Read More

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http://dx.doi.org/10.1186/s12894-020-00609-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164279PMC

Postmenopausal mild hirsutism and hyperandrogenemia due to ovarian Sertoli-Leydig cell tumor: A case report.

Heliyon 2020 Apr 6;6(4):e03746. Epub 2020 Apr 6.

Department of Pathology, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, China.

Among several types of ovarian tumors, Sertoli-Leydig cell tumors are considered significantly rare, accounting for less than 1% of all primary ovarian tumors. Hirsutism caused by ovarian tumors accounts for approximately 1% of all cases of hirsutism. We report a case of a woman with a ovarian Sertoli-Leydig cell tumor who presented with hirsutism. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139105PMC

[Ultrasound characteristics of testicular Leydig cell tumors , , , 1.]

Zhonghua Nan Ke Xue 2019 Apr;25(5):346-350

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.

Objective: To explore the color Doppler ultrasonic characteristics of testicular Leydig cell tumors (LCT) and improve the clinical diagnosis of the disease.

Methods: We retrospectively analyzed 4 cases of testicular LCT diagnosed and treated in our hospital and summarized the experience in the ultrasonic diagnosis of LCT with a review of the relevant literature.

Results: All the 4 testicular LCTs were solitary and quasi-round, 1 in the left and 3 in the right. Read More

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[Virilizing ovarian tumor: the challenges of differential diagnosis].

Probl Endokrinol (Mosk) 2019 12 25;65(4):273-277. Epub 2019 Dec 25.

I.M. Sechenov First Moscow State Medical University.

SertoliLeydig cell tumor is a rather rare type of ovarian neoplasms belonging to the group of sex cordstromal tumors. This malignancy is characterized by androgen overproduction, which results in the so-called virilization and can be accompanied by various metabolic disorders such as abdominal obesity, disturbances of carbohydrate and protein metabolism, and high blood pressure. During differential diagnosis, it is important to identify the source of androgen overproduction. Read More

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http://dx.doi.org/10.14341/probl10222DOI Listing
December 2019

The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency.

FASEB J 2020 May 19;34(5):6111-6128. Epub 2020 Mar 19.

Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.

Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) deficiency causes a disorder of sex development in humans, where affected males are born with female-appearing external genitalia, but are virilized during puberty. The hormonal disturbances observed in the Hsd17b3 knockout mice (HSD17B3KO), generated in the present study, mimic those found in patients with HSD17B3 mutations. Identical to affected humans, serum T in the adult HSD17B3KO mice was within the normal range, while a striking increase was detected in serum A-dione concentration. Read More

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http://dx.doi.org/10.1096/fj.201902384RDOI Listing

Towards understanding leydigioma: do G protein-coupled estrogen receptor and peroxisome proliferator-activated receptor regulate lipid metabolism and steroidogenesis in Leydig cell tumors?

Protoplasma 2020 Jul 16;257(4):1149-1163. Epub 2020 Mar 16.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Kraków, Poland, Gronostajowa 9, 30-387, Kraków, Poland.

Leydig cell tumors (LCT) are the most common type of testicular stromal tumor. Herein, we investigate the G protein-coupled estrogen receptor (GPER) and peroxisome proliferator-activated receptor (PPAR) implication in regulation of lipid homeostasis including the expression of steroidogenesis-controlling molecules in clinical specimens of LCTs and tumor Leydig cells (MA-10). We showed the general structure and morphology of LCTs by scanning electron and light microscopy. Read More

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http://dx.doi.org/10.1007/s00709-020-01488-yDOI Listing

[The pathology of hereditary ovarian tumors].

Ann Pathol 2020 Apr 13;40(2):85-94. Epub 2020 Mar 13.

Institut multisite des hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre Bénite cedex, France. Electronic address:

About 23% of adnexal tumors are related to a hereditary syndrome, most often hereditary breast and ovarian cancer syndrome or Lynch syndrome, responsible of epithelial tumors. However, the pathologist should be aware of rare hereditary syndromes responsible of non-epithelial ovarian tumors. Ovarian tumors associated with germline mutation of BRCA genes are essentially high-grade serous carcinomas of tubal origin, while those seen in Lynch syndrome are most often endometrioid or clear cell carcinomas. Read More

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http://dx.doi.org/10.1016/j.annpat.2020.02.015DOI Listing

Melatonin inhibits apoptosis in mouse Leydig cells via the retinoic acid-related orphan nuclear receptor α/p53 pathway.

Life Sci 2020 Apr 13;246:117431. Epub 2020 Feb 13.

Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun 130118, China; Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China. Electronic address:

Melatonin is an endogenous indoleamine hormone involved in various physiological processes. However, the mechanism of melatonin in mediating Leydig cells function has not been fully explained. In this study, we investigated the mechanism through which melatonin inhibits apoptosis in mouse Leydig cells by activating the retinoic acid-related orphan nuclear receptor (ROR) α/p53 signaling pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117431DOI Listing

Testis-preserving strategies in testicular germ cell tumors and germ cell neoplasia .

Transl Androl Urol 2020 Jan;9(Suppl 1):S24-S30

Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University Hospital of Cologne, Cologne, Germany.

Testicular germ cell tumors (TGCT) are rare malignancies which affect young adults and adolescents between the ages of 15 and 40 years. In suspected malignant TGCT, the treatment of choice is radical orchiectomy. However, in specific cases this routine surgical approach has been challenged in favor of an organ-preserving approach with comparable oncological outcome. Read More

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http://dx.doi.org/10.21037/tau.2019.07.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995842PMC
January 2020

Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells.

J Hazard Mater 2020 06 3;391:122227. Epub 2020 Feb 3.

College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China. Electronic address:

Arsenic poisoning and induced potential lesion is a global concern. However, the exact mechanisms underlying its toxicity especially in male reproductive system still remain unclear. Hence, this study aimed to explore the roles of mTOR and Beclin1-Vps34/PI3K complex during As-induced-toxicity using Rapamycin (mTOR inhibitor), Beclin1 siRNA and 3-methyladenine (3-MA, Vps34/PI3K inhibitor) in testicular stromal cells. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122227DOI Listing
June 2020
4.529 Impact Factor

[Testicular tumors in prepubertal boys-organ preservation possible more often than expected].

Urologe A 2020 Mar;59(3):278-283

Zentrum für Kinder‑, Jugend- und rekonstruktive Urologie, Medizinische Fakultät Mannheim, der Universität Heidelberg, Universitätsklinikum Mannheim GmbH, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

In prepubertal boys, testicular tumors are rare with an incidence between 2 and 5/million. In contrast to testicular tumors in adolescents and adults, more than 2/3 of these tumors are benign. Unfortunately, in Germany in most cases, only malignant tumors (usually yolk sac tumors) are reported to the study center (MAKEI IV and now V). Read More

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http://dx.doi.org/10.1007/s00120-020-01120-0DOI Listing

Hypogonadism and Cryptorchidism.

Front Endocrinol (Lausanne) 2019 15;10:906. Epub 2020 Jan 15.

Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

Congenital cryptorchidism (undescended testis) is one of the most common congenital urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born with normal birth weight ranges from 1.8 to 8. Read More

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http://dx.doi.org/10.3389/fendo.2019.00906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974459PMC
January 2020

Editorial Comment.

Authors:
Clint Cary

J Urol 2020 05 31;203(5):955. Epub 2020 Jan 31.

Department of Urology, Indiana University, Indianapolis, Indiana.

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http://dx.doi.org/10.1097/JU.0000000000000705.02DOI Listing

Editorial Comment.

Authors:
Andreas Hiester

J Urol 2020 05 31;203(5):955. Epub 2020 Jan 31.

Department of Urology, Heinrich-Heine-University, Düsseldorf, Germany.

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http://dx.doi.org/10.1097/JU.0000000000000705.01DOI Listing

MULTILOCULAR PURE LEYDIG CELL TUMOR OF OVARY, FALLOPIAN TUBE, AND EXTRAOVARIAN SOFT TISSUE.

AACE Clin Case Rep 2019 Jan-Feb;5(1):e16-e21. Epub 2019 Jan 30.

Objective: Leydig cell tumors (LCTs) of the ovary may produce androgens and cause virilization. Although they are generally benign, these tumors are typically very small, making them hard to detect by imaging processes.

Methods: We report a case of a multilocular LCT involving the ovarian stroma, fallopian tube, and extra-ovarian soft tissue. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876968PMC
January 2019

Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1.

Gynecol Oncol 2020 03 15;156(3):647-653. Epub 2020 Jan 15.

Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Objective: Germline pathogenic variation in DICER1 underlies a tumor-predisposition disorder with increased risk for cervical embryonal rhabdomyosarcoma and ovarian sex-cord stromal tumors, particularly Sertoli-Leydig cell tumors. The gynecologic and reproductive health of these females has not yet been described.

Methods: All female subjects recruited from November 2011 to July 2018 participating in an epidemiologic study of families with pathogenic DICER1 germline variation were included in this cross-sectional analysis. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.037DOI Listing

Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.

Eur J Endocrinol 2020 Mar;182(3):K15-K24

Child Health Section of University of Glasgow School of Medicine, Queen Elizabeth University Hospital, Glasgow, UK.

Objective: CYP11A1 mutations cause P450 side-chain cleavage (scc) deficiency, a rare form of congenital adrenal hyperplasia with a wide clinical spectrum. We detail the phenotype and evolution in a male sibship identified by HaloPlex targeted capture array.

Family Study: The youngest of three brothers from a non-consanguineous Scottish family presented with hyperpigmentation at 3. Read More

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http://dx.doi.org/10.1530/EJE-19-0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087497PMC

Ovarian vein sampling, and serum and urine testosterone monitoring in ovarian Leydig cell tumors: A report of two cases.

Case Rep Womens Health 2020 Jan 19;25:e00159. Epub 2019 Nov 19.

Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD, United States of America.

Background: Ovarian Leydig cell tumors are rare, testosterone-producing tumors that pose diagnostic challenges.

Cases: A 36-year-old woman presented with 10 years of amenorrhea, facial hair growth and clitoromegaly. A 59-year-old woman presented after 2 years of voice deepening and terminal hair growth. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940683PMC
January 2020

Precocious Puberty Associated with Testicular Hormone-secreting Leydig Cell Tumor.

Cureus 2019 Dec 22;11(12):e6441. Epub 2019 Dec 22.

Pediatrics, King Abdulaziz University Hospital, Jeddah, SAU.

Leydig cell tumors (LCTs) are rare testicular tumors that may be a cause of precocious puberty in males. We present a 5-year-old boy with a five-month history of pubic hair appearance associated with an increase in penile length, scrotal hyperpigmentation, change in body odor, and bone age advanced by two years. His hormonal tests revealed the diagnosis of pseudo precocious puberty. Read More

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http://dx.doi.org/10.7759/cureus.6441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929247PMC
December 2019

Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.

Endocrinology 2020 02;161(2)

The Research Institute of the McGill University Health Centre and the Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, Canada.

Testosterone production occurs in the Leydig cells of the testes and is essential for virilization, development, reproduction, and quality of life. Although the steroidogenic proteins involved in cholesterol conversion to testosterone (T) are well characterized, the causes of reduced T during fetal, neonatal, and adult life remain uncertain. It is well established that normal cellular function is achieved through fine-tuning of multiple rather than single protein networks. Read More

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http://dx.doi.org/10.1210/endocr/bqz036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007878PMC
February 2020

Reduced testicular steroidogenesis in rat offspring by prenatal nicotine exposure: Epigenetic programming and heritability via nAChR/HDAC4.

Food Chem Toxicol 2020 Jan 14;135:111057. Epub 2019 Dec 14.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

Prenatal nicotine exposure (PNE) may lead to offspring's testicular dysplasia. Here, we confirmed the intergenerational effect of PNE on testosterone synthetic function and explored its epigenetic programming mechanism. Pregnant Wistar rats were injected subcutaneously with nicotine (2 mg/kg. Read More

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http://dx.doi.org/10.1016/j.fct.2019.111057DOI Listing
January 2020
2.895 Impact Factor

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

J Urol 2020 05 17;203(5):949-956. Epub 2019 Dec 17.

Department of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Purpose: Leydig cell tumors are rare but they are the most common nongerm cell testicular tumors. Only limited evidence exists for reliably differentiating between benign and malignant Leydig cell tumors and for optimally managing the different types and stages of this rare disease. In this review we synthesize the available evidence on the clinical presentation and clinicopathological characteristics associated with Leydig cell tumor malignancy and management. Read More

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http://dx.doi.org/10.1097/JU.0000000000000705DOI Listing

Ovarian Sertoli-Leydig cell tumour with α-fetoprotein-producing intestinal glandular cells. Clinical case and short review of basic literature.

Pol J Pathol 2019 ;70(3):226-231

Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.

Sertoli Leydig cell tumor of the ovary, is a rare neoplasm from the group of sex cord-stromal tumors of the ovary, accounting for less than 1% of all ovarian tumors. Among the Sertoli Leydig cell tumors, we distinguish a separate group of tumors secreting α-fetoprotein (AFP). The young 24-year-old woman presented to the Clinical Department of Gynaecological Endocrinology at the University Hospital in Krakow due to secondary amenorrhea, hirsutism and worsening abdominal pain for several months. Read More

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http://dx.doi.org/10.5114/pjp.2019.90402DOI Listing
January 2020

Predominance of Granular Cell Tumours among Testicular Tumours of Rabbits (Oryctolagus cuniculi f. dom.).

J Comp Pathol 2019 Nov 1;173:24-29. Epub 2019 Nov 1.

Department of Pathology, University of Veterinary Medicine, Hannover, Germany. Electronic address:

Testicular neoplasms are reported rarely in pet and laboratory rabbits (Oryctolagus cuniculi f. dom.), with interstitial cell tumours being the most commonly described testicular neoplasm. Read More

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http://dx.doi.org/10.1016/j.jcpa.2019.09.012DOI Listing
November 2019

Malignant leydig cell tumor in a 91-year-old man: Case report.

Int Braz J Urol 2019 Nov-Dec;45(6):1260-1265

Departamento de Urologia da Santa Casa de Misericórdia de Ribeirão Preto, São Paulo, Brasil.

Testicle tumors are a rare entity among men population, accounting for only 1-1.5% of all can-cers among men. The stromal tumors of the sexual cord correspond just 4% of all testicular cancers. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0720DOI Listing
January 2020

Microscopic testicular sperm extraction or post-operative sperm reversal in functional Leydig cell tumor: case report.

Transl Androl Urol 2019 Oct;8(5):556-561

Reproductive Medicine Center, Department of Urology and Andrology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

Leydig cell tumors are rare testicular tumors in adults. Hormonal activity is found in 20% of the cases with endocrine abnormalities, which may result in azoospermia. The appropriate management to achieve oncologic control and simultaneously obtain sperm remains a challenge. Read More

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http://dx.doi.org/10.21037/tau.2019.08.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842781PMC
October 2019

Renal cell carcinoma in young FH mutation carriers: case series and review of the literature.

Fam Cancer 2020 Jan;19(1):55-63

Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is an autosomal dominant syndrome caused by heterozygous pathogenic germline variants in the fumarate hydratase (FH) gene. It is characterized by cutaneous and uterine leiomyomas and an increased risk of developing renal cell carcinoma (RCC), which is usually adult-onset. HLRCC-related RCC tends to be aggressive and can metastasize even when the primary tumor is small. Read More

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http://dx.doi.org/10.1007/s10689-019-00155-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026215PMC
January 2020

[Leydig cell hyperplasia of testis in children: a clinicopathological study].

Zhonghua Bing Li Xue Za Zhi 2019 Nov;48(11):851-855

Department of Pathology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

To investigate the clinical, pathological features and differential diagnosis of testicular Leydig cell hyperplasia (LCH) . Clinical data, histological features, immunohistochemical findings, ultrastructural characteristics and follow-up data were analyzed in three cases of LCH. The cases were collected from 2011 to 2014 at Beijing Children's Hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.11.004DOI Listing
November 2019

Leydig cell tumorigenesis - implication of G-protein coupled membrane estrogen receptor, peroxisome proliferator-activated receptor and xenoestrogen exposure. In vivo and in vitro appraisal.

Tissue Cell 2019 Dec 7;61:51-60. Epub 2019 Aug 7.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Gronostajowa 9, 30-387 Krakow, Poland.

The etiology and molecular characteristics of Leydig cell tumor (LCT) are scarcely known. From the research data stems that estrogen can be implicated in LCT induction and development, however it is not investigated in detail. Considering the above, herein we analyzed the relation between G-protein coupled membrane estrogen receptor, peroxisome proliferator-activated receptor and insulin-like family peptides (insulin-like 3 peptide; INSL3 and relaxin; RLN) expressions as well as estrogen level with impact of xenoestrogen (bisphenol A; BPA, tetrabromobisphenol A; TBBPA, and tetrachlorobisphenol A; TCBPA). Read More

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http://dx.doi.org/10.1016/j.tice.2019.08.001DOI Listing
December 2019

Management of Leydig cell tumors of the testis-a case report.

Urol Case Rep 2020 Jan 31;28:101064. Epub 2019 Oct 31.

Medical University Pleven, Bulgaria, "Georgi Kochev"8A str, 5800, Bulgaria.

We report 1 case of Benign Leydig cell tumor. A 45-year-old male was admitted to the Urology department with a large painless mass in the right testis of 1 year duration. The patient underwent radical high right orchiectomy, with a preliminary diagnosis of right testicular tumor. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854074PMC
January 2020

[Contrast-enhanced ultrasonography of testicular tumours].

Authors:
G Lock

Urologe A 2019 Dec;58(12):1410-1417

Klinik für Innere Medizin, Albertinen-Krankenhaus Hamburg, Süntelstr. 11a, 22457, Hamburg, Deutschland.

Scrotal ultrasound with high-resolution transducers and additional display of vascularisation in colour-coded ultrasonography is the method of choice for the detection and characterisation of testicular tumors. Within the last decade, testicular ultrasonography has been further refined and improved by the possibilities of contrast-enhanced ultrasound (CEUS).CEUS may be especially helpful in the assessment of vascularisation disorders (e. Read More

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http://dx.doi.org/10.1007/s00120-019-01065-zDOI Listing
December 2019

SREBP2-STARD4 is involved in synthesis of cholesteryl ester stimulated by mono-butyl phthalate in MLTC-1 cells.

Environ Toxicol 2020 Mar 9;35(3):377-384. Epub 2019 Nov 9.

The Key Laboratory of Modern Toxicology, Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Sterol is synthesized from cholesterol which is from the hydrolysis of stored cholesteryl esters. The process of maintaining cholesterol homeostasis is regulated by SREBP2-STARD4. Lots of researches demonstrated that male steroidogenesis could be interfered by di-n-butyl phthalate (DBP) or monobutyl phthalate (MBP). Read More

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http://dx.doi.org/10.1002/tox.22874DOI Listing

Ovarian tumors: a survey of selected advances of note during the life of this journal.

Authors:
Robert H Young

Hum Pathol 2020 01 22;95:169-206. Epub 2019 Oct 22.

The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

The author reviews highlights of advances in knowledge concerning ovarian tumor pathology since the time of an essay in the first issue of this Journal written by Dr Robert E. Scully, who, both before and for several decades after the Journal was instituted, made many original contributions to the field and was the major architect of the 1973 World Health Organization classification of ovarian tumors which was much more clear and logical than prior ones. The current review considers the neoplasms in essentially the same order as was done in the first issue of this journal and presents a personal look at the highlights of new information concerning various well-known categories, surface epithelial, germ cell, sex cord-stromal, metastatic neoplasms and briefly, benign so-called tumor-like lesions. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.09.002DOI Listing
January 2020
2 Reads

Imaging of DICER1 syndrome.

Pediatr Radiol 2019 10 16;49(11):1488-1505. Epub 2019 Oct 16.

, Minneapolis, USA.

DICER1 syndrome is a highly pleiotropic tumor predisposition syndrome that has been increasingly recognized in the last 10 years. Diseases in the syndrome result from mutations in both copies of the gene DICER1, a highly conserved gene that is critically implicated in micro-ribonucleic acid (miRNA) biogenesis and hence modulation of messenger RNAs. In general, susceptible individuals carry an inherited germline mutation that disables one copy of DICER1; within tumors, a very characteristic second mutation alters function of the other gene copy. Read More

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http://dx.doi.org/10.1007/s00247-019-04429-xDOI Listing
October 2019
6 Reads

[Preliminary investigation of gender assignment in 46,XY disorders of sex development with severe male undermasculinisation].

Zhonghua Er Ke Za Zhi 2019 Oct;57(10):786-791

Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

To explore the feasibility of gender assignment in 46,XY disorders of sex development (DSD) with severe undermasculinisation mainly based on molecular diagnosis. A retrospective study of 45 patients of 46, XY DSD with severe undermasculinisation were admitted between November 2015 and October 2018 at Children's Hospital, Zhejiang University School of Medicine. The initial social gender were all female, of whom the external genital manifestations were Prader 0 to 2; the degree of masculinity was scored using external masculinisation score (EMS); the position and development of the gonads were examined by ultrasound, cystoscopy and laparoscopy, also including assessing the development of the Wolffian tube and the Müllerian tube. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.10.011DOI Listing
October 2019