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    Clinical features and presentation of oral potentially malignant disorders.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Apr 4. Epub 2018 Apr 4.
    Emeritus Professor, King's College London, UK; WHO Collaborating Centre for Oral Cancer, London, UK. Electronic address:
    Oral potentially malignant disorders (OPMDs) are conditions that precede the onset of invasive cancers of the oral cavity. The term embraces precancerous lesions and conditions referred to in earlier World Health Organization (WHO) definitions. Leukoplakia is the most common OPMD; erythroplakia, although rare, is more serious. Read More

    Potentially Malignant Disorders Revisited - The Lichenoid Lesion/ Proliferative Verrucous Leukoplakia Conundrum.
    J Oral Pathol Med 2018 Apr 16. Epub 2018 Apr 16.
    Newcastle University Medicine Malaysia, Iskandar Puteri, Johor, Malaysia.
    Background: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT).

    Methods: A retrospective review of 590 PMD patients treated in Northern England by CO laser surgery between 1996 and 2014 was carried out. Read More

    Management update of potentially premalignant oral epithelial lesions.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 23. Epub 2018 Mar 23.
    Department of Oral and Maxillofacial Surgery, North Memorial Medical Center, Minneapolis, MN, USA. Electronic address:
    The term oral potentially malignant disorders, proposed at the World Health Organization workshop in 2005, has now been renamed potentially premalignant oral epithelial lesions (PPOELs). It is important to differentiate among PPOELs, which is a broad term to define a wide variety of clinical lesions, and oral epithelial dysplasia, which should be reserved specifically for lesions with biopsy-proven foci of dysplasia. PPOELs encompass lesions that include leukoplakia, erythroplakia, erythroleukoplakia, lichen planus, and oral submucous fibrosis. Read More

    Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy.
    F1000Res 2018 6;7:284. Epub 2018 Mar 6.
    Department of Dermatology, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
    Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. Read More

    Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma.
    Oncol Rep 2018 Mar 27. Epub 2018 Mar 27.
    Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
    Notch1 signaling is essential for tissue development and tumor progression. This signaling pathway has also been implicated in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). However, the role of Notch1 expression in OL and its malignant transformation is unknown. Read More

    Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer.
    J Natl Cancer Inst 2018 Mar;110(3)
    UC San Diego Moores Cancer Center, San Diego, CA.
    Background: We have previously shown that gene expression profiles of oral leukoplakia (OL) may improve the prediction of oral cancer (OC) risk. To identify new targets for prevention, we performed a systematic survey of transcripts associated with an increased risk of oral cancer and overexpressed in OC vs normal mucosa (NM).

    Methods: We used gene expression profiles of 86 patients with OL and available outcomes from a chemoprevention trial of OC and NM. Read More

    Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 1. Epub 2018 Mar 1.
    Emory University School of Medicine, Atlanta Oral Pathology, Decatur, GA, USA. Electronic address:
    The term oral potentially malignant disorders (OPMDs) describes a recognizable group of mucosal diseases that have a risk of progressing to squamous cell carcinoma. Oral leukoplakia, the most common OPMD, has a 1% prevalence and reported malignant transformation rates of 2% to 5%. Other OPMDs include erythroplakia, erythroleukoplakia, submucous fibrosis, lesions of reverse smokers, and inherited genetic disorders, such as Fanconi anemia. Read More

    Podoplanin expression as a predictive marker of dysplasia in oral leukoplakia.
    J Craniomaxillofac Surg 2018 Mar 9. Epub 2018 Mar 9.
    Department of Biomedical and Neuromotor Sciences (Head: Prof Lucio Montebugnoli), Section of Oral Sciences, University of Bologna, Italy.
    Purpose: Recent studies have emphasized the role of podoplanin in oral lesions at risk of malignant transformation. We investigated a group of oral leukoplakias (OLs) to determine a possible relation between altered podoplanin expression and dysplasia, and to compare the results with those obtained by other, widely used biomarkers.

    Materials And Methods: The population consisted of 40 consecutive patients with a clinical and histological diagnosis of OL. Read More

    Association of with the Degrees of Dysplasia and Oral Cancer: A Study by Calcofluor White under Fluorescent Microscopy.
    Iran J Pathol 2017 1;12(4):348-355. Epub 2017 Oct 1.
    Dept. of Oral and Maxillofacial Pathology and Microbiology, D .Y. Patil Dental College, school of dentistry l Sector -7, NerulNavi Mumbai , Maharashtra , India.
    Background And Objective: () play a significant role in oral mucosal carcinogenesis. It can be identified using various techniques in cytological smears. But, very few studies have been conducted on histopathological sections using calcofluor white M2R under fluorescent microscopy. Read More

    Proliferative verrucous leukoplakia misdiagnosed as oral leukoplakia.
    J Indian Soc Periodontol 2017 Nov-Dec;21(6):499-502
    Department of Periodontology, Swami Devi Dyal Dental College and Hospital, Barwala, Haryana, India.
    Correct diagnosis of white lesions of the oral cavity is sometimes difficult, because some oral white lesions behave differently and tend to change their appearance with time. Clinicians often wrongly diagnose such lesions as oral leukoplakias and treat simply. Lesions recur and turn malignant. Read More

    Correlation of Vascularization and Inflammation with Severity of Oral Leukoplakia.
    Iran J Pathol 2017 1;12(3):225-230. Epub 2017 Apr 1.
    Shahrekord University of Medical Sciences, Shahrekord, Iran.
    Background & Objective: Changes in submucosal vascularization and inflammation, determined by immunohistochemistry staining, were shown to be correlated with the development of dysplasia and invasiveness of epithelial cells in premalignant and malignant lesions. This study evaluated changes in sections routinely stained with Hematoxylin and Eosin (H&E) in order to investigate vascular density and intensity of inflammatory cells infiltration during the progression of oral leukoplakia with mild dysplasia to Squamous Cell Carcinoma (SCC).The aim of the research was to determine whether changes in sub-mucosal vascularity and inflammatory infiltration of leukoplakia in routine H&E-stained sections could contribute to the assessment of severity of the lesion. Read More

    A Three-MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Cancer.
    Int J Mol Sci 2018 Mar 7;19(3). Epub 2018 Mar 7.
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan.
    Oral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of oral cancer. Plasma from normal, OL, and OSCC patients were evaluated. Read More

    Expression of p53, epidermal growth factor receptor, c-erbB2 in oral leukoplakias and oral squamous cell carcinomas.
    J Cancer Res Ther 2018 Jan-Mar;14(2):388-393
    Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
    Background: Oral cancer is a leading cause of cancer in India and contributes to 12% deaths worldwide. The identification of high-risk oral premalignant lesions such as leukoplakia and intervention at premalignant stages could result in significant loss of mortality and morbidity among these patients. The most frequently observed genetic aberrations in these lesions are of mutations in p53, c-erbB2, and epidermal growth factor receptor (EGFR). Read More

    Characterization of epithelial oral dysplasia in non-smokers: First steps towards precision medicine.
    Oral Oncol 2018 Mar 20;78:119-125. Epub 2018 Feb 20.
    Department of Oral Biological and Medical Sciences, the University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada; BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
    Objectives: Tobacco usage is the strongest risk factor in the development of oral squamous cell carcinoma (OSCC), which mandates careful screening for oral cancers in smokers. However, there are indications that oral potentially malignant lesions, such as oral epithelial dysplasia (OED), in non-smokers (NS) have a higher cancer risk than those in smokers. Without tobacco as an etiology, the development of these lesions in NS may suggest genetic susceptibility. Read More

    Knowledge about oral leukoplakia for use at different levels of expertise, including patients.
    Oral Dis 2018 Mar;24(1-2):174-178
    Department of Oral and Maxillofacial Surgery/Pathology, VU medical center/ACTA, Amsterdam, The Netherlands.
    Objective: The purpose of this contribution is to discuss how the subject of oral leukoplakia might be communicated among the various healthcare workers and also among patients.

    Material And Methods: The discussion is based on the available literature and on many decades of clinical and histopathological experience of the author.

    Results: The literature does not contain guidelines on what level of expertise can be expected from the various dental and medical healthcare workers in the field of oral leukoplakia, nor on how to communicate this disorder with patients. Read More

    Oral erythroplakia-What is it?
    Oral Dis 2018 Mar;24(1-2):138-143
    Section of Periodontology, Oral Microbiology, Oral Radiology, Oral Surgery, Oral Physiology, and Community Dentistry, Department of Odontology, University of Copenhagen, Copenhagen, Denmark.
    Oral erythroplakia is a rare type of lesion, and little is known about the origin of the lesion. It has traditionally been described as the red counterpart of oral leukoplakia, which implies that it is a red lesion that cannot be characterized clinically or pathologically as any other definable lesion. A definition by exclusion is less satisfactory than a positive description to define a lesion, and as erythroplakia probably is related to lichenoid lesions, a new approach to perceive the lesion is proposed based on the clinical features of a fiery red, sharply demarcated lesion situated at a slightly lower level than the surrounding mucosa. Read More

    Oral leukoplakia remains a challenging condition.
    Oral Dis 2018 Mar;24(1-2):179-183
    Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA, USA.
    Crispian Scully had many interests in the realm of oral diseases. But oral leukoplakia was one that piqued his curiosity when he was still an academic neophyte and remained a topic which he studied throughout his enormously productive career. It is easy to understand why. Read More

    Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?
    Oral Dis 2018 Mar;24(1-2):84-88
    Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
    In oral cancer, acquisition of α-smooth muscle actin (α-SMA)-positive fibroblasts, known as myofibroblasts or carcinoma-associated fibroblasts (CAF), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (OPMD) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD. Read More

    Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions.
    Acta Clin Croat 2017 Sep;56(3):369-374
    Institute of Public Health, Skopje, Republic of Macedonia.
    Oral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of different HPV types with oral premalignant lesions, and the potential role of smoking and alcohol use. Read More

    Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
    J Formos Med Assoc 2018 Feb 19. Epub 2018 Feb 19.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. Read More

    Oral lesions as an important marker for HIV progression.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    Laboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil 2 Department of Stomatology, Division of General Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. br.
    Background: Oral hairy leukoplakia (OHL) is a benign lesion caused by Epstein-Barr virus (EBV) replication in the oral epithelium affecting the borders of the tongue. It is strongly associated with immunosuppression, especially in HIV+ adults but is uncommon in pediatric population. The aim of the study is to show the importance of the correct diagnosis of OHL and its influence on HIV treatment. Read More

    [Diagnostic value of optical coherence tomography for oral leukoplakia assessment].
    Stomatologiia (Mosk) 2018 ;97(1):37-39
    Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
    The article presents a comparative analysis of the results of in vivo scanning of oral mucosa leukoplakia with optical coherence tomography (OCT) method and pathological studies in 15 patients (9 females and 6 males aged 27-82). The study revealed specific OCT signs of leukoplakia: even disorder of tissue layering and less clear visualization of lamina propria. OCT is an important stage in the differential diagnosis of leukoplakia of the oral mucosa and significantly complements the clinical and pathomorphological study. Read More

    Systemic and topical photodynamic therapy (PDT) on oral mucosa lesions: an overview.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):123-126
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    Photodynamic Therapy (PDT) is a minimally invasive treatment that has shown promising results in treating preneoplasticlesions. PDT reckons on the administration of a drug (photosensitizer), which can be used in a topical or systemic form. Photodynamic therapy has been successfully used in the management of a variety of pathologies from different anatomical sites, including the head, neck, brain and lungs, hepatobiliary tree and other gastrointestinal and urological pathologies, skin, gynaecological conditions and in vascular anomalies. Read More

    Prevalence of HIV-related oral manifestations and their association with HAART and CD4+ T cell count: a review.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):51-59
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
    HIV infection is one of the major health problem of the last decades. This disease causes a chronic infection that can lead to acquired immunodeficiency syndrome (AIDS). According to the Global AIDS update, released in 2016 by HIV department of World Health Organization (WHO) and by the Joint United Nations Program on HIV/AIDS (UNAIDS), at the end of 2015, 36. Read More

    Assessing Oral Cancer Awareness Among Dental Students.
    J Cancer Educ 2018 Feb 14. Epub 2018 Feb 14.
    Faculty of Dentistry, Department of Oral Diagnosis and Maxillofacial Radiology, Marmara University, Başıbüyük Sağlık Yerleşkesi Başıbüyük Yolu 9/3 Maltepe, 34854, Istanbul, Turkey.
    The aim of this study was to assess oral cancer awareness among undergraduate dental students in Marmara University Faculty of Dentistry. A validated questionnaire which tested oral cancer awareness was given to third- and fifth-year students of the dental faculty of Marmara University. A total of 198 students participated in this survey. Read More

    Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment.
    Medicine (Baltimore) 2018 Feb;97(7):e9932
    Department of Gynecology, Cancer Institute Hospital.
    Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed. Read More

    Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma.
    Oncol Rep 2018 Apr 7;39(4):1793-1804. Epub 2018 Feb 7.
    Department of General Dentistry, The Ninth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200000, P.R. China.
    Oral leukoplakia (OL) is one of the most common oral precancerous lesions with the possibility of malignant transformation, ranging from 17 to 24% of patients with a median follow-up of >7 years. Previous research has revealed that compared with normal oral epithelial tissues, the expression of secretory leukocyte peptidase inhibitor (SLPI) protein is significantly reduced in oral squamous cell carcinoma (OSCC). Based on the above-mentioned research, it is known that SLPI is a potential predictive and diagnostic tool for the progression of oral carcinogenesis. Read More

    Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line.
    Oncol Lett 2018 Mar 19;15(3):3350-3356. Epub 2017 Dec 19.
    Department of Oral Biochemistry, Asahi University School of Dentistry, Mizuho, Gifu 501-0296, Japan.
    To elucidate the genetic events that occur during the development of OSCC, the present study established a model of oral malignancy using a mouse oral squamous cell carcinoma (OSCC) Sq-1979 cell line. Sq-1979 cells were implanted into syngeneic C3H mice. Subsequently, 233 cells and metastatic sub-clones (L cells) from primary OSCC, as well as the metastasized lymph node tissues of Sq-1979-implanted mice were established. Read More

    Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.
    J Formos Med Assoc 2018 May 7;117(5):374-380. Epub 2018 Feb 7.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    A Retrospective 20-Year Analysis of Proliferative Verrucous Leukoplakia and Its Progression to Malignancy and Association with High-risk Human Papillomavirus.
    Head Neck Pathol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.
    Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The aim of this study was to evaluate the malignant potential of PVL and determine its possible association with high-risk human papillomavirus (HPV). Twenty cases with a clinical and biopsy proven diagnosis of PVL were collected from the University of Florida Oral Medicine clinic database. Read More

    Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma.
    J Clin Exp Dent 2017 Dec 1;9(12):e1418-e1424. Epub 2017 Dec 1.
    Associate Professor, Department of Oral and Maxillofacial Pathology PMS College of Dental Science and Research, Thiruvananthapuram, Kerala, India.
    Background: Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim of our study was to compare the expression of podoplanin in oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma with that in normal buccal mucosa by immunohistochemical methods. Read More

    Oral Brush Liquid-Based Cytology: A Study of Concordance between a Cytotechnologist and a Cytopathologist.
    Acta Cytol 2018 2;62(2):121-129. Epub 2018 Feb 2.
    Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, India.
    Objective: Oral cancer accounts for almost 40% of all cancers in the Indian subcontinent. Techniques like oral scrape cytology are helpful in early diagnosis of premalignant lesion and thus prevention of malignant transformation. The purpose of this study is to evaluate the performance of cytotechnologists in assessing the adequacy and preliminary diagnostic accuracy of oral brush liquid-based cytology. Read More

    High HPV16 E6 viral load in the oral cavity is associated with an increased number of bacteria: A preliminary study.
    Biomed Rep 2018 Jan 29;8(1):59-64. Epub 2017 Nov 29.
    Department of Oral and Maxillofacial Surgery, Program of Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
    In a previous study, the present research group reported that males had a significantly higher prevalence of human papillomavirus (HPV)16 than females in oral rinse samples. The objective of the present study was to examine the relationship between HPV16 viral load and clinical factors, including remaining teeth, denture use and numbers of oral bacteria. A total of 124 patients (48 males and 76 females; mean age, 61. Read More

    Oral potentially malignant disorders: risk of progression to malignancy.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    UWA Dental School, The University of Western Australia, Nedlands, Australia.
    Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Read More

    Historical perspective and nomenclature of potentially malignant or potentially premalignant oral epithelial lesions with emphasis on leukoplakia-some suggestions for modifications.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    VU University Medical Center (VUmc)/Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam, The Netherlands. Electronic address:
    Of the potentially (pre)maligant oral epithelial lesions, leukoplakia is the most common. A brief overview of the various definitions of leukoplakia that have been used in the past is presented here. A proposal has been made to modify the current definition. Read More

    Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):456-457
    Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.
    Context: The malignant transformation potential of oral lichen planus (OLP) and related lesions is a subject of great controversy.

    Aim: The aim of this study was to compare the expression of proteins related to apoptosis and tumour suppressor gene processes in OLP, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD).

    Materials And Methods: The immunohistochemical study was carried out to investigate the expressions of survivin and p53 in a total of 30 lesional biopsy specimens - 10 cases each of OLP, OLR and OLD. Read More

    Quantitative and qualitative assessment of argyrophilic nucleolar organizer regions in normal, premalignant and malignant oral lesions.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):360-366
    Department of Oral Pathology, College of Dental Sciences and Research Bopal Dental College, Ahmedabad, Gujarat, India.
    Aim: The aim of the study was to assess the cell proliferation and biologic aggressiveness of the lesions by evaluating the significance of number and dispersal pattern of Argyrophillic Nucleolar organizing Regions (AgNORs) using silver colloid technique in normal mucosa, premalignant and malignant lesions.

    Settings And Design: In-vitro study, lab setting.

    Methods And Material: The study sample consisted of five groups each with a sample size of 10 and a control group. Read More

    The 150 most important questions in cancer research and clinical oncology series: questions 86-93 : Edited by Chinese Journal of Cancer.
    • Authors:
    Chin J Cancer 2018 Jan 22;37(1). Epub 2018 Jan 22.
    Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which spark diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 8 more questions are presented as follows. Question 86. Read More

    Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia.
    J Oral Pathol Med 2018 Apr 13;47(4):388-395. Epub 2018 Feb 13.
    INSERM 1052, CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
    Background: Oral squamous cell carcinoma is a major cause of cancer-associated morbidity and mortality and may develop from oral erythroplakia and leukoplakia (OEL), the most common oral potentially malignant lesions. Our objective was to provide a descriptive overview of the global research activity on OEL over the past decades.

    Methods: We performed a systematic bibliometric analysis of articles and reviews on OEL up to December 31st 2016 using the SCOPUS database. Read More

    Proliferative leukoplakia: proposed new clinical diagnostic criteria.
    Oral Dis 2018 Jan 16. Epub 2018 Jan 16.
    Division of Oral Medicine and Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA, USA.
    Objective: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathologic standpoint and suggest an updated classification.

    Subjects And Methods: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathologic features, and malignant transformation (MT).

    Results: There were 42 patients (median age: 69 years [range:36-88]; 35 females). Read More

    Association between clinical stage of oral cancer and expression of immunohistochemical markers.
    Pol Przegl Chir 2017 Dec;89(6):17-22
    Chair and Department of Oral Surgery, Medical University of Lublin, Poland.
    Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease.

    Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. Read More

    Oral lesions associated with human immunodeficiency virus in 75 adult patients: a clinical study.
    J Korean Assoc Oral Maxillofac Surg 2017 Dec 26;43(6):388-394. Epub 2017 Dec 26.
    Department of Oral Medicine and Diagnosis, School of Dentistry, Lebanese University, Beirut, Lebanon.
    Objectives: The objective of this study was to investigate the presence of oral lesions in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients in a descriptive cross-sectional study, and to establish their presence according to levels of CD4+ cells (including the CD4+/CD8+ cell ratio).

    Materials And Methods: A total of 75 patients infected with HIV were included. Oral lesions were observed and classified using World Health Organization classification guidelines. Read More

    Dysplasia Should Not Be Ignored in Lichenoid Mucositis.
    J Dent Res 2018 Jan 1:22034517748639. Epub 2018 Jan 1.
    1 Faculty of Dentistry, the University of British Columbia, Vancouver, BC, Canada.
    Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. Read More

    Considerations in the diagnosis of oral hairy leukoplakia-an institutional experience.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 15;125(3):232-235. Epub 2017 Nov 15.
    Department of Diagnostic Sciences, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Objective: We report here the 10-year experience with oral hairy leukoplakia (OHL) at the Division of Oral and Maxillofacial Pathology at the University of North Carolina at Chapel Hill, NC, USA.

    Study Design: All the associated hematoxylin and eosin and Epstein-Barr virus encoding region in situ hybridization slides of OHL cases between January 1, 2008, and February 1, 2017, were retrieved and reviewed. Collected demographic characteristics, clinical presentation, medical and social histories were reviewed and reported. Read More

    Uncovering the potential of CD44v/SYNE1/miR34a axis in salivary fluids of oral cancer patients.
    J Oral Pathol Med 2018 Apr 15;47(4):345-352. Epub 2018 Feb 15.
    Department of Life Sciences, School of Sciences, Gujarat University, Gujarat, India.
    Objectives: Late-stage diagnosis is one of the major confounders for poor prognosis of patients with oral cancer owing to lack of a biomarker to diagnose this disease at an early stage. Moreover, till date, invasive biopsies are the only option to assess disease occurrence and progression in this malignancy. Thus, this study aims to identify and assess potential salivary markers in OSCC patients in order to open newer avenues in the field of non-invasive biopsies. Read More

    p53 Codon 72 Gene Polymorphism Studies and p53 Expression by Immunohistochemistry in Oral Lesions as Risk Factor for Malignancy.
    Int J Appl Basic Med Res 2017 Oct-Dec;7(4):243-246
    Department of Surgical Oncology, K. G. Medical University, Lucknow, Uttar Pradesh, India.
    Background: Wild-type p53 nuclear phosphoproteins are critical cell cycle regulatory tumor-suppressor gene. Genetic mutation of p53 gene is common in several head-neck cancers, usually associated with smoking and human papillomavirus (HPV) infection. In India, instead of HPV, tobacco/pan masala chewing is more commonly associated with oral cancer. Read More

    Liaison between heme metabolism and bioenergetics pathways-a multimodal elucidation for early diagnosis of oral cancer.
    Photodiagnosis Photodyn Ther 2018 Mar 4;21:263-274. Epub 2018 Jan 4.
    Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology Shibpur, Howrah, 711103, India. Electronic address:
    Metabolic alterations of oral epithelial cells under oxidative stress are important signatures for early diagnosis of oral cancer. Amongst different metabolic alterations, non-invasive photo-diagnostic methods have been extensively used for determining cellular heme metabolism and accumulation of protoporphyrin IX (PpIX) under administration of suitable photosensitizer. In this study, we report these metabolic alterations by direct analysis of oral exfoliated cells obtained from individuals with prolonged smoking habit without the exogenous administration of any photosensitizer. Read More

    Determinants of Tobacco Use and Prevalence of Oral Precancerous Lesions in Cab Drivers in Bengaluru City, India.
    Int J Prev Med 2017 5;8:100. Epub 2017 Dec 5.
    Department of Public Health Dentistry, KLE Institute of Dental Sciences, Bengaluru, Karnataka, India.
    Background: Tobacco is a most important risk factor for various types of cancer as well as some noncommunicable disease. Around 34.6% of Indian population consume tobacco. Read More

    Immunohistochemical Expression Of Ezrin In Oral Potentially Malignant Disorders-A Descriptive Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S205-S210
    Department of Oral Pathology and Microbiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
    Introduction: Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Read More

    Rapid detection of Candida albicans in oral exfoliative cytology samples by loop-mediated isothermal amplification.
    J Oral Sci 2017 ;59(4):541-547
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry.
    Loop-mediated isothermal amplification (LAMP) rapidly amplifies DNA under isothermal conditions. The aim of this study was to detect Candida albicans and compare the positivity rate in the LAMP reaction with that of conventional methods for oral exfoliative cytology (EC) samples. Sixty-eight EC samples from 53 patients were subjected to LAMP analysis. Read More

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