Appl Immunohistochem Mol Morphol 2021 May 17. Epub 2021 May 17.
Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS) Pathological Anatomy Service, University Hospital Complex of Santiago (CHUS), Santiago de Compostela Oral and Maxillofacial Pathology and Oral Medicine Unit, Department of Stomatology II, University of the Basque Country, Leioa, Spain Special Care Dentistry Centre (CAPE) and Oral Pathology, Department of Stomatology, University of São Paulo School of Dentistry (USP), São Paulo, Brazil.
Bcl-2 is a group of apoptotic proteins that play a key role in cellular homeostasis. Overexpression of Bcl-2 has been associated with the poor prognosis of oral squamous cell carcinoma (OSCC). The aim of this study is to analyze the immunohistochemical expression of Bcl-2 in healthy oral mucosa, different oral potentially malignant disorders and OSCC, and to determine its diagnostic value. Read More