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    Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions.
    Oral Oncol 2017 May 18;68:36-43. Epub 2017 Mar 18.
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
    Objectives: Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transformation of oral precancerous lesions.

    Materials And Methods: Patients with oral precancerous lesions managed at the Nara Medical University Hospital, Japan, (n=120) were enrolled in this study. Read More

    The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma.
    J Oral Pathol Med 2017 Apr 24. Epub 2017 Apr 24.
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
    Objectives: To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues.

    Materials And Methods: A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia samples and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, oral leukoplakia and normal controls was evaluated by immunohistochemical assay. Read More

    Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.
    Transl Oncol 2017 Apr 20;10(3):396-409. Epub 2017 Apr 20.
    Cancer Research Institute (CRI), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India. Electronic address:
    We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and that several changes are associated with this progression, including amplification of 8q24.3, deletion of 8p23. Read More

    Evaluation of Different Laser-Supported Surgical Protocols for the Treatment of Oral Leukoplakia: A Long-Term Follow-Up.
    Photomed Laser Surg 2017 Apr 20. Epub 2017 Apr 20.
    3 Unit of Oral Pathology and Medicine and Laser-assisted Oral Surgery, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, Faculty of Medicine and Surgery, University of Parma , Parma, Italy .
    Purpose: The aim of this study was to evaluate the long-term success rate of oral leukoplakia treatments by using different laser-supported surgical protocols.

    Patients And Methods: Overall, 2347 diagnosed homogeneous oral leukoplakias were treated with CO2 laser and were included in this study. Different surgical protocols (P) were used: P1 (SV = superficial scanning) was a complete superficial vaporization of the leukoplakia by a scanning mode in two passages respecting an overlapping. Read More

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

    Genetic changes in oral premalignant lesion, condition, and oral squamous cell carcinoma - A study based on inhibition of G2M phase by colchicines.
    Indian J Dent Res 2017 Jan-Feb;28(1):55-58
    Department of Oral Medicine and Radiology, Farooquia Dental College and Hospital, Mysore, Karnataka, India.
    Aims: To assess the percentage of cell arrested in G2M phase by colchicine in the early detection and prognosis of oral cancer, by comparison of oral squamous cell with leukoplakia and oral submucous fibrosis (OSMF) using flow cytometry analysis.

    Materials And Methods: Biopsy samples 5 each of clinically diagnosed and histopathologically confirmed case of leukoplakia, OSMF, and squamous cell carcinoma (SCC) are included in the study.

    Results: Colchicines significantly inhibited the growth of oral SCC-9 cell line by arresting G2M phase of the cell cycle (94. Read More

    Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.
    Med Oral Patol Oral Cir Bucal 2017 Apr 8. Epub 2017 Apr 8.
    University of Talca Lircay Av. S/N, Talca, Chile Zip code 3460000
    Background: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce.

    Material And Methods: This study investigated the frequency of OD in a Chilean population. Read More

    Oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case.
    BMJ Case Rep 2017 Apr 6;2017. Epub 2017 Apr 6.
    Oral Medicine, University of Bristol Dental Hospital, Bristol, UK.
    Oral hairy leukoplakia (OHL) is an oral mucosal lesion that is associated with Epstein-Barr virus infection. It commonly presents as an asymptomatic, non-removable white patch on the lateral borders of the tongue in individuals who are immunocompromised. Historically, OHL was thought to be pathognomonic of HIV infection; however, it is now an established phenomenon in a range of conditions affecting immune competence. Read More

    Estimation of Serum Protein in Oral Potentially Malignant Disorders and Oral Malignancy - A Cross-Sectional Study.
    J Clin Diagn Res 2017 Feb 1;11(2):ZC17-ZC19. Epub 2017 Feb 1.
    Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University , Piparia, Vadodara, Gujarat, India .
    Introduction: In carcinogenesis, increased oxidative stress and weakened antioxidant defense produces damage to the macromolecules like proteins. Thus, protein can act as potential biomarker in oral premalignant and malignant lesions.

    Aim: To determine and compare the levels of serum proteins in Oral Submucuous Fibrosis (OSMF), Oral Leukoplakia (OL), Nicotina Stomatitis (NS), Oral Malignancy (OM) and Healthy Controls (HC). Read More

    Implication for second primary cancer from visible oral and oropharyngeal premalignant lesions in betel-nut chewing related oral cancer.
    Head Neck 2017 Apr 6. Epub 2017 Apr 6.
    Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, Taiwan.
    Background: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Read More

    Surgical management of chronic hyperplastic candidiasis refractory to systemic antifungal treatment.
    J Lab Physicians 2017 Apr-Jun;9(2):136-139
    Department of Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
    Chronic hyperplastic candidiasis (CHC), earlier known as candidal leukoplakia, is a variant of oral candidiasis that classically presents as a white patch on the commissures of the oral mucosa and it is mostly caused by Candida albicans. Clinically, the lesions are usually asymptomatic and regress after appropriate antifungal therapy and correction of the underlying cause. If the lesions are untreated, a small portion may develop dysplasia and later progress into carcinoma. Read More

    A Retrospective Evaluation of Partial Glossectomy for Early Tongue Cancer Using a Carbon Dioxide Laser.
    Photomed Laser Surg 2017 Mar 30. Epub 2017 Mar 30.
    1 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine , Kobe, Japan .
    Objective: The purpose of this study was to retrospectively evaluate the postoperative results of partial glossectomy for early tongue cancer using a carbon dioxide laser (CO2 laser).

    Background Data: CO2 lasers are frequently used for the excision or treatment of soft tissue in a range of diseases, including oral cancer, leukoplakia, mucocele, anomalies of the labial and lingual frenum, and peri-implantitis.

    Materials And Methods: We retrospectively reviewed 31 primary cases of early superficial tongue cancer that were treated using CO2 lasers. Read More

    Micronutrients and Their Role in Oral Cancer: A Review.
    West Indian Med J 2016 Mar 15;65(2):383-388. Epub 2016 Mar 15.
    Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.
    Cancer is one of the leading causes of death across the world. Oral cancer is the sixth most common type of cancer in the world. The incidence of oral cancer increases with the increase in the consumption of carcinogens such as tobacco and alcohol as seen in south and southeast Asia. Read More

    Topical agents for oral cancer chemoprevention: A systematic review of the literature.
    Oral Oncol 2017 Apr 2;67:153-159. Epub 2017 Mar 2.
    Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA; Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
    Objectives/hypothesis: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD).

    Methods: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence. Read More

    Predictive value of p63, ki-67, and survivin expression in oral leukoplakia: A tissue microarray study.
    Microsc Res Tech 2017 Mar 27. Epub 2017 Mar 27.
    Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Brazil.
    The aim of this study was to analyze the immunohistochemical expression of survivin, ki-67, and p63 in oral leukoplakic lesions, histopathologically differentiated into dysplastic and nondysplastic. A tissue microarray containing 57 samples of biopsies from clinically classified lesions, such as leukoplakia, was immunolabeled for survivin, ki-67, and p63. Samples were scored for percentage of positively stained. Read More

    Hypoacetylation of acetyl-histone H3 (H3K9ac) as marker of poor prognosis in oral cancer.
    Histopathology 2017 Mar 22. Epub 2017 Mar 22.
    Experimental Pathology Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
    Aims: Epigenetics refers to changes in cell characteristics that occur independently of modifications to the DNA sequence. Oral carcinogenesis is influenced by modifications in epigenetic mechanisms, including changes in histones, which are proteins that support chromatin remodeling for the dynamic regulation of gene expression and silencing. The dysregulation of histone acetylation can lead to the uncontrolled activity of different genes, thereby triggering events associated with malignant transformation. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Analysis of silver binding nucleolar organizer regions in exfoliative cytology smears of potentially malignant and malignant oral lesions.
    Biotech Histochem 2017 1;92(2):115-121. Epub 2017 Mar 1.
    e Department of Oral Medicine and Radiology , Pacific Dental College and Hospital , Udaipur , Rajasthan , India.
    Nucleolar organizer regions are nucleolar components that contain proteins that are stained selectively by silver methods; they can be identified as black dots throughout the nucleolus and are known as silver binding nucleolar organizer regions (AgNOR). The number of AgNOR is related to the cell cycle and the proliferative activity of the cells. We investigated AgNOR using exfoliative cytology smears of potentially malignant oral lesions. Read More

    Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study.
    J Oral Pathol Med 2017 Mar 14. Epub 2017 Mar 14.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Background: Oral submucous fibrosis (OSF) is one of the well-recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue.
    J Oral Pathol Med 2017 Mar 10. Epub 2017 Mar 10.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Morioka, Iwate, Japan.
    Background: Oral lichen planus (OLP) is a T-cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Read More

    Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population.
    J Maxillofac Oral Surg 2017 Mar 13;16(1):53-57. Epub 2016 May 13.
    Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.
    Aim: The aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).

    Materials And Methods: The study included 60 patients (15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of β2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Read More

    Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana.
    J Korean Assoc Oral Maxillofac Surg 2017 Feb 20;43(1):29-36. Epub 2017 Feb 20.
    Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
    Objectives: Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). People with AIDS are much more vulnerable to infections, including opportunistic infections and tumors, than people with a healthy immune system. The objective of this study was to correlate oral lesions associated with HIV/AIDS and immunosuppression levels by measuring clusters of differentiation 4 (CD4) cell counts among patients living in the middle western regions of Ghana. Read More

    Hospital-based epidemiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population.
    Int Dent J 2017 Mar 9. Epub 2017 Mar 9.
    Department of Oral Medicine, Peking University School and Hospital of Stomatology, National Engineer Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
    Objective: The aim of this review was to analyse, systematically, hospital-based epidemiological information concerning the malignant transformation rate (MTR) of oral leukoplakia (OL) in a Chinese population, as well as the associated risk factors.

    Methods: Four electronic databases were searched for studies dealing with OL and related risk factors, including age, gender, type of lesion, site, and smoking and drinking habits.

    Results: The MTR of OL in the hospital-based Chinese population ranged from 4% to 13%, based on the studies analysed. Read More

    Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study.
    Braz Oral Res 2017 Mar 6;31(0):e19. Epub 2017 Mar 6.
    Universidade Federal do Rio Grande do Sul - UFRGS, Department of Oral Pathology, Porto Alegre, RS, Brazil.
    To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with oral leukoplakia (n = 30) and oral squamous cell carcinoma (n = 22). Cell scrapings and the biopsy were performed at the site of the lesion and histological slides were prepared for the immunocytochemical analysis of exfoliated oral mucosal cells and for the immunohistochemical analysis of biopsy tissues using E-cadherin and involucrin. Read More

    Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma.
    Cancer Cell Int 2017 2;17:34. Epub 2017 Mar 2.
    Key laboratory of cell differentiation and apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Background: G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene inhibited the malignant phenotype in OSCC cells, suggesting that GPRC5A also functions as a tumor suppressor in oral cancer. However, the molecular mechanisms underlying GPRC5A deficiency in head and neck squamous cell carcinoma (HNSCC) are still unclear. Read More

    Environmental heavy metal as a potential risk factor for the progression of oral potentially malignant disorders in central Taiwan.
    Cancer Epidemiol 2017 Apr 2;47:118-124. Epub 2017 Mar 2.
    Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan. Electronic address:
    Objective: Oral cancer (OC) is a leading cause of death from cancer in men between the ages of 25 and 44 years in Taiwan. The overall 5-year survival rates for the four OC stages (I-IV) in Taiwan are approximately 70%, 30%, 20%, and 10%, respectively, indicating the importance of the early diagnosis of oral potentially malignant disorders (OPMDs). Previous studies indicated an association between the OC incidence and certain environmental heavy metal concentrations. Read More

    Knowledge, Attitude, and Practice of Women in Slums of Pimpri, Chinchwad, Pune, Maharashtra, India, regarding Usage of Mishri.
    J Contemp Dent Pract 2017 Mar 1;18(3):218-221. Epub 2017 Mar 1.
    Department of Public Health Dentistry, Shri. Yashwantrao Chavan Memorial Medical & Rural Development Foundation's Dental College & Hospital, Ahmednagar, Maharashtra, India.
    Introduction: Mishri is one of the form of smokeless tobacco, which is a roasted, powdered preparation made by baking tobacco on a hot metal plate until it is uniformly black, after which it is powdered. It is noted that mishri use is more commonly used by the women of low socioeconomic status, hence the need was felt to conduct this study among women mishri users of slums. Also, the consequences of mishri use are little known, hence an effort is made to find out its ill-effect on oral health. Read More

    Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.
    Cancer Med 2017 Apr 3;6(4):730-738. Epub 2017 Mar 3.
    Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
    Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)-β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. Read More

    Assessing Oral Cancer Awareness Among Dentists.
    J Cancer Educ 2017 Mar 1. Epub 2017 Mar 1.
    Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Marmara University, Güzelbahçe Büyükciftlik Sok. No:6 34365 Nişantaşı, İstanbul, Turkey.
    The aim of this study was to assess oral cancer awareness among dentists who attended 101st FDI World Dental Congress, İstanbul, Turkey. Among 170 dentists who agreed to participate, there were 13 oral surgeons, 6 restorative dentists, 4 endodontists, 4 orthodontists, 6 periodontists, 5 pedodontists, and 14 prosthodontists. Knowledge of oral cancer risk factors and diagnosis procedures, dentists' attitude towards oral cancers, management practice regarding oral cancer, and oral cancer information sources were assessed using 25 questions. Read More

    Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue.
    Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.
    Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.
    There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

    Betel nut chewing, oral premalignant lesions, and the oral microbiome.
    PLoS One 2017 22;12(2):e0172196. Epub 2017 Feb 22.
    University of Guam Cancer Research Center, Mangilao, Guam, United States of America.
    Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Read More

    Analysis of plasma lipid peroxidation and antioxidant enzymes status in patients of oral leukoplakia: A case control study.
    J Int Soc Prev Community Dent 2016 Dec;6(Suppl 3):S213-S218
    Department of Oral Basic and Clinical Sciences, Qaseem Private Colleges, Faculty of Dentistry, Qassim Province, Kingdom of Saudi Arabia.
    Aims And Objectives: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including oral cancer. Mostly, all oral cancer lesions are preceded by a stage of premalignancy. The present study aims to evaluate lipid peroxidation and antioxidant status in the venous blood of patients with different clinicopathologic stages of leukoplakia. Read More

    Proliferative verrucous leukoplakia: diagnosis, management and current advances.
    Braz J Otorhinolaryngol 2017 Jan 24. Epub 2017 Jan 24.
    Federal University of Santa Catarina, Department of Pathology, Florianopolis, SC, Brazil. Electronic address:
    Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

    Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. Read More

    Differentiation-Dependent LMP1 Expression Is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells.
    J Virol 2017 Apr 29;91(8). Epub 2017 Mar 29.
    Department of Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Epstein-Barr virus (EBV)-associated diseases of epithelial cells, including tumors that have latent infection, such as nasopharyngeal carcinoma (NPC), and oral hairy leukoplakia (OHL) lesions that have lytic infection, frequently express the viral latent membrane protein 1 (LMP1). In lytically infected cells, LMP1 expression is activated by the BRLF1 (R) immediate early (IE) protein. However, the mechanisms by which LMP1 expression is normally regulated in epithelial cells remain poorly understood, and its potential roles in regulating lytic reactivation in epithelial cells are as yet unexplored. Read More

    Letter to the Editor: Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL?
    Med Oral Patol Oral Cir Bucal 2017 Mar 1;22(2):e142-e143. Epub 2017 Mar 1.
    Faculdade de Odontologia de Piracicaba - UNICAMP, Departamento de Diagnóstico Oral - Semiologia, Av. Limeira, 901 CEP 13.414-903, Piracicaba - São Paulo - Brasil,

    Phenotypic characterization of oral mucosa: what is normal?
    J Oral Pathol Med 2017 Jan 31. Epub 2017 Jan 31.
    Institute of Anatomy, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
    Background: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure.

    Methods: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors. Read More

    [Analysis of comprehensive treatment of oral leukoplakia by laser ablation].
    Stomatologiia (Mosk) 2016 ;95(6):33-35
    Central Research Institute of Stomatology and Maxillofacial Surgery Health Ministry, Moscow, Russia.
    The article presents data statistics of surgical treatment of leukoplakia by laser ablation for 2014 were examined and operated on 12 patients with verrucous and erosive forms of leukoplakia of the oral mucosa using a diode laser. Only 5 (42%) showed positive results in 7 (58%) patients had recurrent disease, often in the localization of the lesion on the tongue. It is possible that relapse may be associated with incomplete excision of the lesion due to anatomical and morphological features of the oral mucosa in various topographical areas. Read More

    ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia.
    Oncol Lett 2017 Jan 10;13(1):321-328. Epub 2016 Nov 10.
    Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-0815, Japan.
    Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. Read More

    Oral cancer screening for high-risk individuals in the primary healthcare setting using an active approach.
    J Oral Pathol Med 2017 Jan 25. Epub 2017 Jan 25.
    Graduate Program in Dentistry, Pontifical Catholic University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Oral squamous cell carcinoma (OSCC) is considered a major public health problem. The diagnosis often occurs in advanced stages, causing high morbidity and mortality, and therefore, prevention strategies should be advocated. This study aimed to investigate a model of OSCC screening for high-risk individuals in the Family Health Strategy's (FHS) scenario. Read More

    Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients.
    Ann Otol Rhinol Laryngol 2017 Apr 19;126(4):340-343. Epub 2017 Jan 19.
    4 New York Center for Voice and Swallowing Disorders, New York, New York, USA.
    Objective: Metformin is an oral anti-hyperglycemic agent used to treat type 2 diabetes mellitus (DM). In vitro and animal models have shown that metformin can prevent the progression of oral lesions to carcinoma; however, there is conflicting data in the clinical literature regarding risk reduction for malignancy in head and neck cancer (HNC).

    Study Design: Case series. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma.
    Mediators Inflamm 2016 8;2016:5715719. Epub 2016 Dec 8.
    Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
    Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions-oral leukoplakia (OLK) and oral lichen planus (OLP)-to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. Read More

    Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia.
    J Oral Pathol Med 2016 Dec 30. Epub 2016 Dec 30.
    Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University Medical Centre Rostock, Rostock, Germany.
    Background: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leucoplakia (OL).

    Materials And Methods: A total of 131 histological preparations [oral leukoplakia/hyperkeratosis without dysplasia (OL; n = 49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n = 33), with moderate dysplasia (OL-SIN2; n = 13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n = 36)] were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression. Data were compared within the groups. Read More

    Vascular alterations after photodynamic therapy mediated by 5-aminolevulinic acid in oral leukoplakia.
    Lasers Med Sci 2017 Feb 21;32(2):379-387. Epub 2016 Dec 21.
    General Pathology Department, School of Dentistry, University of São Paulo, Av. Prof Lineu Prestes, 2227 - Cidade Universitária, 05508-000, São Paulo, SP, Brazil.
    Impairment of vascular functions after photodynamic therapy (PDT) is frequently associated with tumor remission and is considered one of the main antineoplastic PDT effects. Vascular alterations in oral leukoplakia (OL) treated with PDT have not yet been described. The aim of this study was to evaluate the effect of topical 5-ALA-mediated PDT on the vascular network of 4NQO-induced OL in rats. Read More

    Topical oral cavity chemoprophylaxis using isotretinoin rinse: A 15-year experience.
    Laryngoscope 2016 Dec 21. Epub 2016 Dec 21.
    Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, U.S.A.
    Objectives/hypothesis: To determine the utility of isotretinoin oral rinses as a method of chemoprevention for recurrent oral cavity squamous cell carcinoma (SCC), carcinoma in situ, and dysplasia.

    Study Design: Retrospective cohort study.

    Methods: One hundred forty-three patients were initially enrolled in the study; however, 18 were excluded due to inability to tolerate therapy. Read More

    A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia.
    Contemp Clin Dent 2016 Oct-Dec;7(4):493-499
    Department of Oral Pathology, North Bengal Dental College and Hospital, Darjeeling, West Bengal, India.
    Context: Oral cancer is the third most prevalent malignancy in India. Leukoplakia is its most common precursor lesion.

    Aims: This study aimed at evaluation of the Ki-67 expression and thereby detection of the dysplastic potential in histopathologically nondysplastic oral leukoplakia (OL). Read More

    Estimation of salivary sialic acid in oral premalignancy and oral squamous cell carcinoma.
    Contemp Clin Dent 2016 Oct-Dec;7(4):451-456
    Department of Oral Pathology and Microbiology, MGV'S KBH Dental College and Hospital, Nashik, Maharashtra, India.
    Aims: Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Read More

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