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Dent J (Basel) 2019 Feb 7;7(1). Epub 2019 Feb 7.

Oral Medicine Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, 1983969411 Tehran, Iran.

Diagnosis of oral white lesions might be quite challenging. This review article aimed to introduce a decision tree for oral white lesions according to their clinical features. General search engines and specialized databases including PubMed, PubMed Central, EBSCO, Science Direct, Scopus, Embase, and authenticated textbooks were used to find relevant topics by means of MeSH keywords such as "mouth disease", "oral keratosis", "oral leukokeratosis", and "oral leukoplakia". Read More

Oral Oncol 2019 Feb 17;89:30-33. Epub 2018 Dec 17.

Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland. Electronic address:

Recent advances in DNA sequencing technology have facilitated rapid advances in the analysis of the human microbiome and its role in human disease. Several studies have now shown that OSCC and some oral premalignant conditions are associated with alterations in the oral microbiome. These studies raise questions regarding the role of the oral microbiome in the progression of oral malignancies and whether microbiome change is a significant risk factor in the development of oral cancer. Read More

Front Physiol 2018 22;9:1911. Epub 2019 Jan 22.

Department of Oral Medicine, Peking University School of Stomatology, Beijing, China.

Photodynamic therapy (PDT) has demonstrated promising results in the treatment of oral leukoplakia. This study evaluated the clinical efficacy and side effects of PDT in the treatment of Chinese patients with oral leukoplakia. Twenty-nine patients with oral leukoplakia were enrolled in this study, including patients with both homogenous and non-homogenous lesions and various dysplastic tissues. Read More

J Oral Pathol Med 2019 Feb 4. Epub 2019 Feb 4.

Department of oral pathology, Xiangya Stomatological Hospital, Central South University, No 72 Xiangya Road, Changsha, Hunan, China.

Background: Oral submucous fibrosis (OSF) has been reported frequently in India and other countries in South Asia. There are few reports on the clinicopathological features of OSF in China, where OSF is an epidemic. This study analyses the clinicopathological features of OSF in Hunan Province, China. Read More

J Oral Pathol Med 2019 Feb 3. Epub 2019 Feb 3.

Department of Research, Saveetha Institute of Medical and Technical sciences, Chennai.

Background: Metabolomics is the study of metabolome which describes the full repertoire of small molecules and the analysis of salivary metabolomics may help in identifying tumor specific biomarkers for early diagnosis and prediction of tumor progression. The aim of the study was to evaluate the clinical utility of salivary metabolites in oral leukoplakia and oral squamous cell carcinoma.

Methods: Salivary metabolomic profile of patients diagnosed with oral leukoplakia (n=21) and oral squamous cell carcinoma (n=22) were compared with apparently normal controls (n=18) using QTOF- liquid chromatography mass spectrometry. Read More

Cytotechnology 2019 Feb 2. Epub 2019 Feb 2.

Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi, Bengaluru, Karnataka, 560 056, India.

Areca nut chewing habits are associated with several oral manifestations like leukoplakia, submucous fibrosis and oral squamous cell carcinoma. Although numerous evidence on areca toxicity is known but the mechanistic pathway of disease causation is to be studied. Aqueous areca nut extract treated A549 cells showed reduced cell viability by 48 h with IC value of 0. Read More

Methods Mol Biol 2019 ;1929:763-771

Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.

Oncologic relevant members of S100 proteins are described as promising biomarkers in molecular pathology for risk estimation in oral neoplasia exhibiting different stages of malignancy: gingiva as healthy tissue, irritation fibroma as benign, leukoplakia as precancerous, and oral squamous cell carcinoma as malignant entity. Gene expression levels of S100A4 (metastasin), S100A7 (psoriasin), S100A8 (calgranulin A), and S100A9 (calgranulin B) were analyzed using quantitative RT-PCR. In addition, immunohistochemistry-based microscopy was used to examine cellular localization and distribution of these biomarkers in tissue sections. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):130-134

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Dyskeratosis congenita (DC) is a rare disease and a genetic heterogeneity of bone marrow failure, characterized by muco-cutaneous triad of mucosal leukoplakia, abnormal skin pigmentation, nails dystrophy and often involving multiple organs or systems. The inheritance patterns of DC include X-linked recessive, autosomal dominant and recessive patterns. However, the inheritance patterns in 30%-40% of DC patients remained unknown. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1970-1972

Dept. of Oral and Maxillofacial Surgery, National Hospital Organization Hamada Medical Center.

Oral leukoplakia is the most common premalignant or potentially malignant lesion in the oral mucosa. This retrospective study examined 67 lesions from 62 patients with clinical diagnoses of oral leukoplakia who underwent surgical excision in our department from 2015 to 2017. The patients comprised 22 men and 40 women. Read More

Eur J Dent Educ 2019 Jan 25. Epub 2019 Jan 25.

Department of Community Dentistry, The Hebrew University - Hadassah School of Dental Medicine, Jerusalem, Israel.

Introduction: Clinical photography is an important tool in teaching, clinical practice and academia especially for mucosal pathologies. Our aim was to examine differences in attitude toward clinical photography for mucosal pathologies among students.

Methods: Questionnaires about clinical photography were completed by students in dental teaching hospitals in Birmingham (U. Read More

Ann Otol Rhinol Laryngol 2019 Jan 24:3489419826131. Epub 2019 Jan 24.

1 Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives:: Describe the demographics and clinical manifestations of laryngeal cryptococcosis. Develop a simple approach to the diagnostic workup and treatment of localized laryngeal cryptococcal infection.

Methods:: A new case of laryngeal cryptococcosis encountered at our institution is presented and placed in context of the literature surrounding prior reported cases. Read More

Asian Pac J Cancer Prev 2019 Jan 25;20(10):283-287. Epub 2019 Jan 25.

Department of Public Health Dentistry, Sharavathi Dental College and Hospital, Shimoga, India. Email:

Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Read More

Pediatr Dermatol 2019 Jan;36(1):149-151

Department of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain.

Int J Cancer 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology, New York University School of Medicine, NY, USA, 10016.

Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. Read More

Head Neck Pathol 2019 Jan 22. Epub 2019 Jan 22.

University of Florida, Gainesville, USA.

Verrucous hyperkeratosis (VH), verrucous carcinoma (VC) and the relentless, truly pre-malignant variant proliferative verrucous leukoplakia often exhibit lichenoid histologic features that may create a diagnostic dilemma for pathologists. This study aims to evaluate and categorize the frequency and the histopathologic patterns of lichenoid features seen in these lesions. Following IRB approval, cases of VH and VC from 1994 to 2014 were retrieved from the archives of UF Oral Pathology Biopsy Service. Read More

Head Neck Pathol 2019 Jan 22. Epub 2019 Jan 22.

Atlanta Oral Pathology, Emory Decatur Hospital, Emory University School of Medicine, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Read More

Acta Stomatol Croat 2018 Dec;52(4):340-347

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Background: The literature data show insufficient knowledge and awareness about oral cancer among dental and medical students.

Objective: To assess the knowledge of graduating dental students regarding oral cancer and to assess their awareness regarding the prevention and early detection of oral cancer. Also student's smoking status was examined aimed to investigate their attitude towards smoking as a risk factor for development of oral cancer and to assess the prevalence of smoking among dental students. Read More

Endocr Metab Immune Disord Drug Targets 2019 Jan 18. Epub 2019 Jan 18.

Ionian Department, University of Bari "Aldo Moro", Bari. Italy.

Background And Objective: Oral cancer is one of the most common malignancies that affect human beings across the world and early detection of oral cancer is believed to reduce the morbidity significantly. Fluorescence diagnosis is emerging as a promising method in the differentiation of cancerous lesions and thus helping in the determination of resolution for the surgical resection of affected area of malignancy very accurately. The aim of this study was to evaluate the usefulness of an autofluorescence hand held device (OralID) to detect oral premalignant lesions. Read More

J Exp Ther Oncol 2019 Jan;13(1):59-63

Resident, MOH, Department of Oral and Maxillofacial Surgery, King Khalid Hospital, Najran, Kingdom of Saudi Arabia.

Background: Risk factors such as chronic use of tobacco, smoking and alcohol consumption of individual's lifestyle may possibly influence the significant role in the etiopathogenesis of precancerous lesions (PL) and Conditions (PC) and lead to oral cancer. Previous studies have revealed that genetic factors have contributed to a remarkable extent in the development of this chronic disease. Limited studies have confirmed that ABO blood groups remain reportedly possible genetic factor to the specific disease such as oral malignant. Read More

PLoS One 2019 18;14(1):e0210901. Epub 2019 Jan 18.

Environment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan.

A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including leukoplakia or oral submucous fibrosis were recruited. Read More

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):307-313

Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India.

Context: Salivary analytes may be used as biomarkers for translational and clinical applications. Heat shock proteins (Hsps) are ubiquitous, highly conserved proteins found in all prokaryotic and eukaryotic species. Hsp27, a low molecular weight protein, may act as a salivary biomarker. Read More

J Craniomaxillofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.

Purpose: The aim of this prospective work was to examine oral leukoplakia for their podoplanin expression to determine whether podoplanin expression is associated with the degree of dysplasia.

Materials And Methods: We took biopsy samples from 50 patients with oral leukoplakia in 2013. The preparations studied by immunohistochemistry were analyzed in correlation with the degree of dysplasia and other clinicopathological variables. Read More

Photodiagnosis Photodyn Ther 2019 Jan 8. Epub 2019 Jan 8.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, PR China. Electronic address:

Oral leukoplakia (OLK) is one of the most common oral potentially-malignant disorders (OPMD) with complex causes, a long disease course and a high tendency for recrudescence. Although a variety of methods exist for treating this disease, canceration rates remain high. Herein, we described a case of 72-year-old male patient with OLK of the palatine mucous membrane who had achieved complete remission after being treated with five sessions of plum-blossom needle (PBN) assisted 5-aminolevulinic acid-photodynamic therapy (ALA-PDT). Read More

J Cell Physiol 2019 Jan 9. Epub 2019 Jan 9.

Environment-Omics-Disease Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Areca nut has been evaluated as a group I carcinogen to humans. However, the exact compounds of areca nut causing oral cancer remain unproven. Previous findings from our lab revealed that arecoline N-oxide (ANO), a metabolite of arecoline, exhibits an oral fibrotic effect in immune-deficient NOD/SCID mice. Read More

Oral Dis 2019 Jan 8. Epub 2019 Jan 8.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

J Int Soc Prev Community Dent 2018 Nov-Dec;8(6):513-522. Epub 2018 Nov 29.

Department of Oral Pathology and Microbiology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.

Aims And Objective: The aim of this study is to investigate the expression of p53 protein and Ki-67 antigen in normal oral mucosa and oral leukoplakia with different grades of dysplasia using immunohistochemistry and to clarify the correlation of the expression of these cell cycle regulatory proteins.

Materials And Methods: A total of 20 archival tissue blocks obtained from our department which were diagnosed as mild ( = 5), moderate ( = 5), and severe dysplasia ( = 5) with normal mucosa ( = 5) as a control. Positivity of Ki-67 and p53 was analyzed using Statistical Package for the Social Sciences (IBM Corp. Read More

Hua Xi Kou Qiang Yi Xue Za Zhi 2018 12;36(6):613-618

Stomatological Center, Xiangya Second Hospital of Central South University, Changsha 410011, China.

Objective: This study aimed to investigate the expression and relationship of microtubule-associated protein 1 light chain 3 (LC3) and mammalian target of rapamycin (mTOR) in normal oral mucosa, oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC). This work also analyzed the relationship between expression levels and clinical factors. This study evaluated the clinical value of LC3B and mTOR as indices to determine the carcinogenic potential of OLK. Read More

Br J Oral Maxillofac Surg 2019 Jan 23;57(1):79-81. Epub 2018 Dec 23.

Tata Memorial Hospital, Parel Mumbai, 400012.

Dyskeratosis congenita is a rare genetic disorder that results from progressive failure of the bone marrow. It presents with a classic triad of reticular pigmentations of the skin, dystrophic nails, and oral leukoplakia; patients rarely develop cancers. We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue. Read More

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3635-3641. Epub 2018 Dec 25.

Department of Oral Medicine and Radiology, M. M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India. Email:

Objectives: The present observational study was conducted with an aim to evaluate the efficacy of diode laser in management of homogenous oral leukoplakia (OL) and reticular oral lichen planus (OLP), so that these potentially malignant disorders can be limited and further malignant transformation can be prevented. Further the assessment of associated postoperative complications after laser therapy was also carried out. Study Design: Present study was carried out using diode laser 810nm on 60 subjects, of whom 30 subjects were of homogenous OL and 30 subjects were of reticular OLP aged between 20 – 60 years, the diagnosis of which was histopathologically confirmed. Read More

Int J Cancer 2018 Dec 23. Epub 2018 Dec 23.

Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.

There are no studies of oral health in relation to esophageal cancer in Africa, or of Eastern Africa's endemic dental fluorosis, an irreversible enamel hypo-mineralization due to early-life excessive fluoride intake. During 2014-18, we conducted a case-control study of squamous cell esophageal cancer in Eldoret, western Kenya. Odds ratios (AORs (95% confidence intervals)) were adjusted for design factors, tobacco, alcohol, ethnicity, education, oral hygiene and missing/decayed teeth. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Dyskeratosis congenita (DKC) also known as Zinsser-Cole-Engman syndrome is a progressive genetic disease with a classical presentation characterised by a triad of reticulate pigmentation of skin, nail dystrophy and leukoplakia. It may be a multisystem disease with the involvement of haematological, gastrointestinal, genitourinary, neurological, ophthalmic, pulmonary and skeletal system. We report a sporadic case of DKC presenting with poikiloderma, nail dystrophy and oral leukoplakia. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

Oncoimmunology 2018 21;7(12):e1496880. Epub 2018 Sep 21.

Univ Lyon, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France.

Oral squamous cell carcinoma (OSCC) is a major cause of cancer-associated morbidity and mortality and may develop from oral premalignant lesions (OPL). An improved molecular classification of OPL may help refining prevention strategies. We identified two main OPL gene-expression subtypes, named immunological and classical, in 86 OPL (discovery dataset). Read More

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland.

Background: The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous-like lesions with high risk of malignancy, and its biomarkers.

Methods: A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta-analysis was possible for human papillomavirus (HPV), aneuploidy, Ki-67, and p53. Read More

Oral Oncol 2018 Dec 24;87:58-63. Epub 2018 Oct 24.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objectives: To elucidate the risk of malignant transformation to invasive oral cancer by subtypes of oral potentially malignant disorders (OPMD) and to examine the independent effects of risk factors, particularly alcohol drinking, by subtype based on a nationwide oral cancer screening program targeting at general population with habits of smoking and/or betel quids chewing.

Materials And Methods: The total of 8501 subjects diagnosed as different subtypes of OPMDs from the Taiwanese screening program between 2004 and 2009 were followed up over time to ascertain the occurrence of invasive oral cancer. The hazard ratios of malignant transformation were estimated by using Cox proportional hazards regression model. Read More

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

Transpl Infect Dis 2018 Nov 18:e13030. Epub 2018 Nov 18.

Department of Stomatology, Federal University of Paraná, Curitiba, Brazil.

Background: Fanconi anemia (FA) is a rare genetic disease usually characterized by bone marrow failure and congenital malformations. The risk of development of malignancies in the oral cavity of FA patients, such as squamous cell carcinoma (SCC), increases significantly after a hematopoietic stem cells transplant (HSCT), and may also be linked with the presence of human papillomavirus (HPV) infections in the oral cavity. We investigated the prevalence and the HPV genotypes in oral mucosa of Brazilian FA patients. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

Lasers Med Sci 2019 Feb 15;34(1):209-221. Epub 2018 Nov 15.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.

A series of studies are dedicated to research the clinical outcomes of oral leukoplakia (OLK) treated with carbon dioxide laser (CO laser); however, the results vary from studies especially related to recurrence and malignant transformation. Hence, we performed this meta-analysis to precisely evaluate the malignant transformation of OLK dealt with CO laser and investigate the association between its malignant transformation and kinds of related risk factors, such as gender, clinical classification, long duration of leukoplakia, and degree of epithelial dysplasia and lesion regions. We performed a systematic search of the Cochrane Library, EMBASE, Pubmed, Web of Science, and SCOPUS. Read More

J Int Soc Prev Community Dent 2018 Sep-Oct;8(5):396-401. Epub 2018 Oct 8.

Department of Public Health Dentistry, Sibar Institute of Dental Sciences and Research, Guntur, Andhra Pradesh, India.

Objective/aim: The aim of this study is to measure the association between oral mucosal lesions (OMLs) and habit of tobacco and alcohol in the population of Guntur city, Andhra Pradesh, South India.

Material And Method: A cross-sectional study was conducted on 300 participants in Guntur city with the habit of tobacco and alcohol consumption in various forms who were selected by stratified cluster random sampling technique. Guntur city was divided into four zones, that is, North, East, South, and West; and two administrative wards were randomly selected from each zone as clusters. Read More

Photodiagnosis Photodyn Ther 2018 Oct 31. Epub 2018 Oct 31.

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai, 200072, PR China. Electronic address:

Objective: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral leukoplakia (OLK).

Methods: This systematic review aimed to address the following focused question: "Is photodynamic therapy effective in the management of oral leukoplakia?'' PubMed/Medline, EMBASE, ISI Web of Knowledge, OVID, CNKI, and WANFANG DATA were searched up to and including June 2018 using different combinations of the following keywords: photodynamic therapy, leukoplakia, oral dysplasia, oral precancers, and oral premalignant lesions.

Results: Sixteen studies were included in the present study. Read More

Acta Odontol Latinoam 2018 Aug;31(2):77-81

Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Anatomía Patológica, Argentina.

Tumor hypoxia is an important indicator of cancer prognosis. Among the different genes that are upregulated by hypoxia is carbonic anhydrase IX, which combines carbon dioxide and water to form bicarbonate and hydrogen. Although expression of this enzyme is very low in normal tissues, carbonic anhydrase IX is overexpressed in several types of cancer. Read More

Head Neck Pathol 2018 Oct 29. Epub 2018 Oct 29.

College of Dentistry, University of Florida, Gainesville, FL, USA.

Chronic ulcerative stomatitis (CUS) is a poorly understood disease with clinical and histologic overlap with lichen planus (LP). Unlike classic LP, direct immunofluorescence (DIF) studies in cases of CUS exhibit a granular pattern of IgG in nuclei of basal and parabasal cells. This study assesses the demographic, clinical, histologic, and DIF features of CUS. Read More

Dent Mater 2018 12 22;34(12):1756-1768. Epub 2018 Oct 22.

University of Regensburg Medical Center, Department of Conservative Dentistry and Periodontology, 93042 Regensburg, Germany.

Objective: Information on patients with real or claimed adverse reactions towards dental materials in large patient cohorts is rare. Therefore, the aim of the present study was to investigate patients reporting on complaints and symptoms to dental materials over a 16-year period.

Methods: Five hundred patients were characterized by one single dental team regarding age and sex distribution, subjective complaints and objective intraoral symptoms, and allergy status relevant to dental materials. Read More

Stomatologiia (Mosk) 2018 ;97(5):23-26

I.M. Sechenov First State Medical University, Moscow, Russia.

Research objective was assessment of a possibility of primary diagnosis of viruses Epstein-Burr, a cytomegalovirus, a virus of herpes of the 6th type in oral liquid and also influences of herpes infection on development and the clinical course of precancer diseases of the oral mucosa and the red border of lips (RBL). Profound clinic-immunological examination is conducted to 60 patients: the first group are have made 20 patients with an erosive and ulcer form of the lichen planus, the second - 20 people with an erosive form of a leukoplakia, a third - 20 people without diseases of the oral mucosa. As a result of work detection herpes infection is revealed high (90%). Read More

Environ Health Prev Med 2018 Oct 20;23(1):50. Epub 2018 Oct 20.

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Infection and inflammation account for approximately 25% of cancer-causing factors. Inflammation-related cancers are characterized by mutagenic DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. Our previous studies demonstrated the formation of 8-oxodG and 8-nitroguanine in the tissues of cancer and precancerous lesions due to infection (e. Read More

Photomed Laser Surg 2018 Oct 19. Epub 2018 Oct 19.

Oral Medicine Section, Department of Surgical Sciences, CIR-Dental School, University of Turin , Turin, Italy .

Objective: The purpose of this prospective analysis was to evaluate the efficacy of erbium-substituted yttrium aluminum garnet (Er:YAG) laser compared with that of conventional surgery, regarding the long-term outcome of nondysplastic oral leukoplakias (OL).

Background: To date, this comparison has never been performed.

Methods: Patients were randomly allocated to two different groups: some underwent surgical excision with traditional scalpel (Group TrSc) and others underwent an ablative session with Er:YAG laser (Group Las), with these modalities: 1. Read More

Cureus 2018 Aug 6;10(8):e3111. Epub 2018 Aug 6.

Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, JPN.

Objective: Fluorescence visualization devices are screening devices that can be used to examine lesions of the oral mucosa non-invasively. We observed oral squamous cell carcinoma (OSCC) and leukoplakia using the IllumiScan(Shofu, Kyoto, Japan) fluorescence visualization device and examined its usefulness and characteristics.

Methods: We investigated 31 OSCC and nine leukoplakia in patients who were examined using the IllumiScan and treated in our department from January 2017 to February 2018. Read More

Sensors (Basel) 2018 Oct 10;18(10). Epub 2018 Oct 10.

SIB Labs, Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.

Many oral diseases, such as oral leukoplakia and erythroplakia, which have a high potential for malignant transformations, cause abnormal structural changes in the oral mucosa. These changes are clinically assessed by visual inspection and palpation despite their poor accuracy and subjective nature. We hypothesized that non-invasive bioimpedance spectroscopy (BIS) might be a viable option to improve the diagnostics of potentially malignant lesions. Read More

Indian J Med Res 2018 Jul;148(1):35-40

WHO Collaborating Centre for Oral Cancer; King's College London, London, UK.

Smokeless tobacco (SLT) use has many oral effects including oral cancer, leukoplakia and erythroplakia, oral submucous fibrosis (if mixed with areca nut), loss of periodontal support (recession) and staining of teeth and composite restorations. This review was aimed to provide information to identify oral lesions that occur due to the use of smokeless tobacco so that effective interventions can be undertaken to reduce morbidity and mortality from the use of SLT. Read More