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    Betel nut chewing, oral premalignant lesions, and the oral microbiome.
    PLoS One 2017 22;12(2):e0172196. Epub 2017 Feb 22.
    University of Guam Cancer Research Center, Mangilao, Guam, United States of America.
    Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Read More

    Analysis of plasma lipid peroxidation and antioxidant enzymes status in patients of oral leukoplakia: A case control study.
    J Int Soc Prev Community Dent 2016 Dec;6(Suppl 3):S213-S218
    Department of Oral Basic and Clinical Sciences, Qaseem Private Colleges, Faculty of Dentistry, Qassim Province, Kingdom of Saudi Arabia.
    Aims And Objectives: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including oral cancer. Mostly, all oral cancer lesions are preceded by a stage of premalignancy. The present study aims to evaluate lipid peroxidation and antioxidant status in the venous blood of patients with different clinicopathologic stages of leukoplakia. Read More

    Proliferative verrucous leukoplakia: diagnosis, management and current advances.
    Braz J Otorhinolaryngol 2017 Jan 24. Epub 2017 Jan 24.
    Federal University of Santa Catarina, Department of Pathology, Florianopolis, SC, Brazil. Electronic address:
    Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

    Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. Read More

    Differentiation-dependent LMP1 expression is required for efficient lytic EBV reactivation in epithelial cells.
    J Virol 2017 Feb 8. Epub 2017 Feb 8.
    Departments of Oncology, Cellular and Molecular Biology, Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Epstein-Barr virus (EBV)-associated diseases of epithelial cells, including tumors such as nasopharyngeal carcinoma (NPC) that have latent infection, and oral hairy leukoplakia (OHL) lesions that have lytic infection, frequently express the viral latent membrane protein 1 (LMP1). In lytically-infected cells, LMP1 expression is activated by the BRLF1 (R) immediate-early (IE) protein. However, the mechanisms by which LMP1 expression is normally regulated in epithelial cells remain poorly understood, and its potential roles in regulating lytic reactivation in epithelial cells are as yet unexplored. Read More

    Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL?
    Med Oral Patol Oral Cir Bucal 2017 Feb 4. Epub 2017 Feb 4.
    Faculdade de Odontologia de Piracicaba - UNICAMP, Departamento de Diagnóstico Oral - Semiologia, Av. Limeira, 901 CEP 13.414-903, Piracicaba - São Paulo - Brasil,
    In their recent publication, Garcia-Pola et al. (2016) suggested the development of proliferative verrucous leukoplakia (PVL) in oral lichen planus (OLP). It was described as a preliminary study, where this association supposedly occurred (1). Read More

    Phenotypic characterization of oral mucosa: what is normal?
    J Oral Pathol Med 2017 Jan 31. Epub 2017 Jan 31.
    Institute of Anatomy, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
    Background: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure.

    Methods: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors. Read More

    [Analysis of comprehensive treatment of oral leukoplakia by laser ablation].
    Stomatologiia (Mosk) 2016 ;95(6):33-35
    Central Research Institute of Stomatology and Maxillofacial Surgery Health Ministry, Moscow, Russia.
    The article presents data statistics of surgical treatment of leukoplakia by laser ablation for 2014 were examined and operated on 12 patients with verrucous and erosive forms of leukoplakia of the oral mucosa using a diode laser. Only 5 (42%) showed positive results in 7 (58%) patients had recurrent disease, often in the localization of the lesion on the tongue. It is possible that relapse may be associated with incomplete excision of the lesion due to anatomical and morphological features of the oral mucosa in various topographical areas. Read More

    ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia.
    Oncol Lett 2017 Jan 10;13(1):321-328. Epub 2016 Nov 10.
    Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-0815, Japan.
    Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. Read More

    Oral cancer screening for high-risk individuals in the primary healthcare setting using an active approach.
    J Oral Pathol Med 2017 Jan 25. Epub 2017 Jan 25.
    Graduate Program in Dentistry, Pontifical Catholic University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Oral squamous cell carcinoma (OSCC) is considered a major public health problem. The diagnosis often occurs in advanced stages, causing high morbidity and mortality, and therefore, prevention strategies should be advocated. This study aimed to investigate a model of OSCC screening for high-risk individuals in the Family Health Strategy's (FHS) scenario. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma.
    Mediators Inflamm 2016 8;2016:5715719. Epub 2016 Dec 8.
    Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
    Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions-oral leukoplakia (OLK) and oral lichen planus (OLP)-to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. Read More

    Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia.
    J Oral Pathol Med 2016 Dec 30. Epub 2016 Dec 30.
    Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University Medical Centre Rostock, Rostock, Germany.
    Background: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leucoplakia (OL).

    Materials And Methods: A total of 131 histological preparations [oral leukoplakia/hyperkeratosis without dysplasia (OL; n = 49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n = 33), with moderate dysplasia (OL-SIN2; n = 13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n = 36)] were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression. Data were compared within the groups. Read More

    Vascular alterations after photodynamic therapy mediated by 5-aminolevulinic acid in oral leukoplakia.
    Lasers Med Sci 2017 Feb 21;32(2):379-387. Epub 2016 Dec 21.
    General Pathology Department, School of Dentistry, University of São Paulo, Av. Prof Lineu Prestes, 2227 - Cidade Universitária, 05508-000, São Paulo, SP, Brazil.
    Impairment of vascular functions after photodynamic therapy (PDT) is frequently associated with tumor remission and is considered one of the main antineoplastic PDT effects. Vascular alterations in oral leukoplakia (OL) treated with PDT have not yet been described. The aim of this study was to evaluate the effect of topical 5-ALA-mediated PDT on the vascular network of 4NQO-induced OL in rats. Read More

    Topical oral cavity chemoprophylaxis using isotretinoin rinse: A 15-year experience.
    Laryngoscope 2016 Dec 21. Epub 2016 Dec 21.
    Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, U.S.A.
    Objectives/hypothesis: To determine the utility of isotretinoin oral rinses as a method of chemoprevention for recurrent oral cavity squamous cell carcinoma (SCC), carcinoma in situ, and dysplasia.

    Study Design: Retrospective cohort study.

    Methods: One hundred forty-three patients were initially enrolled in the study; however, 18 were excluded due to inability to tolerate therapy. Read More

    A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia.
    Contemp Clin Dent 2016 Oct-Dec;7(4):493-499
    Department of Oral Pathology, North Bengal Dental College and Hospital, Darjeeling, West Bengal, India.
    Context: Oral cancer is the third most prevalent malignancy in India. Leukoplakia is its most common precursor lesion.

    Aims: This study aimed at evaluation of the Ki-67 expression and thereby detection of the dysplastic potential in histopathologically nondysplastic oral leukoplakia (OL). Read More

    Estimation of salivary sialic acid in oral premalignancy and oral squamous cell carcinoma.
    Contemp Clin Dent 2016 Oct-Dec;7(4):451-456
    Department of Oral Pathology and Microbiology, MGV'S KBH Dental College and Hospital, Nashik, Maharashtra, India.
    Aims: Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Read More

    Correlation analysis of oral lesion sizes by various standardized criteria.
    Am J Otolaryngol 2016 Nov - Dec;37(6):502-506. Epub 2016 Jul 12.
    University of Minnesota, Department of Otolaryngology. Electronic address:
    Objective: Requirements of an NCI contract examining a novel treatment for leukoplakia were to compare standard bi-dimensional measurement of oral lesions to examine for correlation with Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and to examine the feasibility of digital image analysis for automated measurements.

    Study Design: Retrospective review.

    Methods: We examined 13 patients by bi-dimensional measurement and compared these measurements to 1) RECIST criteria, 2) scalar digital measurements using a standardized measuring device within the photograph, and 3) pixel number. Read More

    [Precancerous lesions of the buccal epithelium].
    Ann Dermatol Venereol 2017 Feb 6;144(2):100-108. Epub 2016 Dec 6.
    Service de pathologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
    Squamous cell carcinomas of the oral cavity and lips consistently have a high incidence (they constitute the fifth most common form of cancer in France) and carry a heavy prognosis, particularly if diagnosed late. According to different studies, between 10 and 80% of such carcinomas occur in a pre-existing or precancerous lesion. The World Health Organisation (WHO) recommends the use of two terms for such lesions: precursor lesions, i. Read More

    Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients.
    Braz Oral Res 2016 Nov 28;30(1):e118. Epub 2016 Nov 28.
    Universidade de São Paulo - USP, Special Care Dentistry Center, Department of Oral Pathology, São Paulo, SP, Brazil.
    Oral manifestations are common findings in human immunodeficiency virus (HIV) infected patients and frequently influence the overall health. Oral hairy leukoplakia (OHL) is strongly associated with HIV infection demonstrating its relationship with the individual's immune status and progression of immunosuppression. This study aims to retrospectively evaluate OHL in HIV patients, analyzing its incidence, demographic aspects and possible changes in clinical and epidemiological profile of the disease over 17 years. Read More

    Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia.
    World J Clin Cases 2016 Nov;4(11):356-363
    Isadora Luana Flores, Alan Roger Santos-Silva, Ricardo Della Coletta, Marcio Ajudarte Lopes, Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.
    Aim: To elucidate the profile of the salivary proteome.

    Methods: Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests.

    Results: A total of two hundred and eighty-three proteins were confidently identified in saliva. Read More

    Reduced CX3CL1 Secretion Contributes to the Susceptibility of Oral Leukoplakia-Associated Fibroblasts to Candida albicans.
    Front Cell Infect Microbiol 2016 11;6:150. Epub 2016 Nov 11.
    State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University Chengdu, China.
    Candida leukoplakia (OLK) is a kind of oral leukoplakia combined with chronic candidal infection, which plays an important role in the malignant transformation of OLK. However, little is known about the etiology, including susceptibility of leukoplakia to candidal adhesion, invasion and infection. Some antimicrobial peptides secreted by oral epithelial cells or fibroblasts potentially have antifungal activities against Candida albicans (C. Read More

    Interventional laser surgery for oral potentially malignant disorders: a longitudinal patient cohort study.
    Int J Oral Maxillofac Surg 2017 Mar 17;46(3):337-342. Epub 2016 Nov 17.
    Department for Health, University of Bath, Bath, Somerset, UK.
    Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Read More

    Leukoplakia-A Diagnostic and Management Algorithm.
    J Oral Maxillofac Surg 2016 Oct 26. Epub 2016 Oct 26.
    Associate Surgeon, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston; Associate Professor, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA.
    Oral white lesions are frequently encountered in daily practice. Most white lesions are benign (eg, reactive keratoses or keratoses from inflammatory conditions) and the diagnosis is usually evident from the clinical presentation and histopathology. Leukoplakia is a common condition characterized by an increased risk for malignant transformation. Read More

    Exophytic Verrucous Hyperplasia of the Oral Cavity – Application of Standardized Criteria for Diagnosis from a Consensus Report
    Asian Pac J Cancer Prev 2016 Jan;17(9):4491
    Stomatology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia
    Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Read More

    Immunohistochemical study of p21 and Bcl-2 in leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma.
    J Exp Ther Oncol 2016 Nov;11(4):285-292
    University of Taif, Faculty of Dentistry, Basic Dental Sciences, Taif, Kingdom of Saudi Arabia.
    Background: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia).

    Objectives: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma. Read More

    A Clinical Study of Oral Mucosal Lesions in Patients Visiting a Tertiary Care Centre in Central India.
    Indian J Otolaryngol Head Neck Surg 2016 Dec 24;68(4):413-416. Epub 2015 Jun 24.
    Department of ENT, PCMS & RC, Bhopal, India.
    The aim of this study was to find the frequency of various oral mucosal lesions in relation to age, sex, site and associated addiction habits. This retrospective study was done in tertiary care centre including 1280 patients of oral mucosal lesions. Clinical findings and detailed history of their addiction habits with frequency and duration was noted from the existing data. Read More

    Cryosurgery with refrigerant gas as a therapeutic option for the treatment of leukoplakia: a case report.
    Gen Dent 2016 Nov-Dec;64(6):61-64
    Leukoplakia is a nondetachable, potentially malignant, white lesion that is commonly found in smokers of advanced age. Leukoplakia occurs more frequently in men; however, there is a higher index of dysplastic changes and malignant transformation in women. The proposed treatments for this disease range from monitoring to surgical excision. Read More

    Expression of Epstein-Barr virus among oral potentially malignant disorders and oral squamous cell carcinomas in the South Indian tobacco-chewing population.
    J Oral Pathol Med 2016 Oct 5. Epub 2016 Oct 5.
    Department of Pathology, M. S. Ramaiah Medical College & Hospital, Bangalore, Karnataka, India.
    Background: Oral cancer is the sixth most common malignancy in the world. Viruses are the causative agents of approximately 10-15% of all cancers worldwide (Cancers, 6, 2014 and 2155). The tumorigenic roles of Epstein-Barr virus in oral cancer are unclear. Read More

    Signal regulatory protein α associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages.
    Oncotarget 2016 Dec;7(49):81305-81321
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
    Signal regulatory protein α (SIRPα) is a cell-surface protein expressed on macrophages that are regarded as an important component of the tumor microenvironment. The expression of SIRPα in oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC), and further explored the role of SIRPα on the phenotype, phagocytosis ability, migration, and invasion of macrophages in OSCC were investigated. The expression of SIRPα in OLK was higher than in OSCC, correlating with the expression of CD68 and CD163 on macrophages. Read More

    Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer.
    Arch Oral Biol 2016 Dec 8;72:21-32. Epub 2016 Aug 8.
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:
    Objective: To investigate the relationships between two single-nucleotide polymorphisms at miR-146a C>G (rs2910164) and miR-1269b G>C (rs7210937) and the risk of developing oral premalignant lesions (OPLs), oral squamous cell carcinoma (OSCC), pharyngeal SCC (PSCC), and oral and pharyngeal SCC (OPSCC).

    Design: Genotyping of miR-146a C>G and miR-1269b G>C was performed in two case-control studies using the TaqMan assay. A total of 197 healthy control subjects, 241 OPLs patients, and 188 OPSCC patients who habitually chewed betel quid (BQ) were recruited into one case-control study. Read More

    Prevalence of oral cancer, oral potentially malignant disorders and other oral mucosal lesions in Cambodia.
    Ethn Health 2016 Oct 26:1-15. Epub 2016 Oct 26.
    b Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry , University of Malaya , Kuala Lumpur , Malaysia.
    Objectives: To obtain data on the prevalence of oral mucosal lesions (OMLs) among Cambodians, and to assess the relationship between known risk habits of oral diseases with prevalence of oral potentially malignant disorders (OPMDs).

    Design: This was a population-based, cross-sectional study whereby subjects were adults aged 18 years old and above. A workshop on the identification of OML was held to train and calibrate dental officers prior to data collection in the field. Read More

    Low prevalence of transcriptionally active human papilloma virus in Indian patients with HNSCC and leukoplakia.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Nov 22;122(5):609-618.e7. Epub 2016 Jun 22.
    Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India. Electronic address:
    Objectives: In the present study, we comprehensively analyzed the prevalence of transcriptionally active human papilloma virus (HPV) in tissue samples of Indian patients with leukoplakia, predominantly hyperplastic lesions and head and neck squamous cell carcinoma (HNSCC). In addition, saliva samples from patients with HNSCC were screened for HPV detection.

    Study Design: P16 overexpression was analyzed by immunohistochemistry. Read More

    HERG1 potassium channel expression in potentially malignant disorders of the oral mucosa and prognostic relevance in oral squamous cell carcinoma.
    Head Neck 2016 Nov 30;38(11):1672-1678. Epub 2016 Apr 30.
    Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.
    Background: HERG1 potassium channel plays a critical role in the cell proliferation.

    Methods: HERG1 protein expression was analyzed by immunohistochemistry (IHC) in 62 patients with oral leukoplakias and 100 patients with oral squamous cell carcinomas (OSCC). HERG1 mRNA levels were assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 22 patients with primary head and neck squamous cell carcinoma (HNSCC). Read More

    GSTM1 null polymorphism prevalence in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: A polymerase chain reaction study.
    Indian J Dent Res 2016 Jul-Aug;27(4):353-358
    Department of Oral Medicine and Radiology, D. A. P. M. R. V. Dental College, Bengaluru, Karnataka, India.
    Context: Tobacco abuse is a well-known risk factor for potentially malignant disorders as well as oral squamous cell carcinoma. Factors that influence tobacco-exposed individuals developing a malignancy may include the combination of total tobacco exposure and genetic susceptibility.

    Aim: This study was undertaken to determine the prevalence of the glutathione S-transferase M1 (GSTM1) null polymorphism in oral leukoplakia and oral squamous cell carcinoma patients in South Indian population. Read More

    Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality.
    J Cancer Epidemiol 2016 18;2016:8134832. Epub 2016 Sep 18.
    Department of Dentistry, Jawaharlal Nehru Medical College & Hospital, Kalyani, West Bengal 74123, India.
    Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening. Read More

    Expression of matrix metalloproteinase-9 in oral potentially malignant disorders: A systematic review.
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):474-479
    Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
    Matrix metalloproteinase-9 (MMP-9) is an inducible enzyme. Oral potentially malignant disorders (OPMDs) are considered as the early tissue changes that happen due to various habits such as smoking tobacco, chewing tobacco or stress. This alteration in the tissues alters the expression of MMP-9. Read More

    Human MutL homolog 1 immunoexpression in oral leukoplakia and oral squamous cell carcinoma: A prospective study in Indian population.
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):453-461
    Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India.
    Background: Mammalian mismatch repair system is responsible for maintaining genomic stability during repeated duplications, and human MutL homolog 1 (hMLH1) protein constitutes an important part of it. Various isolated studies have reported the altered expression of hMLH1 in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). Research is lacking in the quantitative estimation and comparison of hMLH1 expression in OL and OSCC. Read More

    Meta-analysis on clinicopathologic risk factors of leukoplakias undergoing malignant transformation.
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):354-361
    Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bengaluru, Karnataka, India.
    Context: Leukoplakia is classified under the term potentially malignant disorder. This term does not suggest the clinician or the patient about the severity of the disease to undergo a malignant transformation. Thus, there arises a need to identify the risk factors associated with malignant transformation (MT) to predict it at the earliest. Read More

    Single nucleotide polymorphisms as markers of genetic susceptibility for oral potentially malignant disorders risk: Review of evidence to date.
    Oral Oncol 2016 Oct;61:146-51
    Centre for Global Health, National Cancer Institute, Bethesda, USA. Electronic address:
    Background: Oral cancers are preceded by oral potentially malignant disorders (OPMD). Understanding genetic susceptibility for OPMD risk could provide an opportunity for risk assessment of oral cancer through early disease course. We conducted a review of single nucleotide polymorphism (SNP) studies for OPMD risk. Read More

    Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma.
    J Oral Pathol Med 2016 Sep 29. Epub 2016 Sep 29.
    Department of Pathology, Rambam Medical Center, Bat Galim, Haifa, Israel.
    Background: Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca).

    Methods: A retrospective clinicopathologic and immunohistochemical analysis of 97 tumor specimens from 78 patients (13 patients with proliferative verrucous leukoplakia-associated squamous cell carcinoma (n = 32) and conventional squamous cell carcinoma from the buccal mucosa, gingiva, and palate (n = 65) was conducted. Read More

    Oral leukoplakia associated with amalgam restorations.
    J Oral Sci 2016 ;58(3):445-8
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University.
    The World Health Organization has defined oral leukoplakia (OL) as "a white patch or plaque of the oral mucosa that cannot be characterized clinically or pathologically as any other disease". A 21-year-old male with OL presented with a bilateral burning sensation in the buccal mucosa. The patient had amalgam restorations, and an epicutaneous patch test indicated a positive response to amalgam. Read More

    Prevalence of Carcinomatous Foci in Oral Leukoplakia: A Clinicopathologic Study of 546 Indian Samples.
    J Clin Diagn Res 2016 Aug 1;10(8):ZC78-83. Epub 2016 Aug 1.
    Assistant Dental Surgeon, Taluk Hospital , Wandoor, Malappuram, Kerala, India .
    Introduction: Oral Leukoplakia (OL), the most common potentially malignant disorder, is diagnosed clinically on the basis of exclusion of other lesions. In a country like India, where prevalence of oral cancer is very high, the issue of carcinomatous foci within OL at the time of initial diagnosis of leukoplakia has never been addressed before.

    Aim: To estimate the prevalence and risk factors for epithelial dysplasia as well as carcinoma within OL lesions at the time of initial clinical presentation in an Indian population with high prevalence of tobacco use. Read More

    Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma.
    J Clin Diagn Res 2016 Aug 1;10(8):ZC100-3. Epub 2016 Aug 1.
    Professor and Head, Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, India .
    Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder. Among the cell types in the stroma, mast cells play an important role in tumourigenesis through various mechanisms.

    Aim: The present study was aimed at comparing the mast cell count among normal oral mucosa, leukoplakia and Oral squamous cell carcinoma (OSSC) and to evaluate the possible role of mast cells in carcinogenesis. Read More

    Assessment of micronuclei frequency in individuals with a habit of tobacco by means of exfoliated oral buccal cells.
    J Int Soc Prev Community Dent 2016 Aug;6(Suppl 2):S143-7
    Intern, Kamineni Institute of Dental Sciences, Hyderabad, Telangana State, India.
    Aims And Objectives: To study the genotoxic effects of tobacco on the exfoliated buccal epithelial cells in patients with oral precancerous lesions (OPLs) and Patients with tobacco habit but without oral precancerous lesion(habit controls) by using micronucleus assay as well as the quantification and detection of the biomarkers in these premalignant lesions which will be helpful in finding those patients who are at higher risk for malignant transformation.

    Materials And Methods: Forty samples were collected from the right and left side of buccal epithelial cells obtained from 20 individuals, i.e. Read More

    The prognostic value of GLUT-1 staining in the detection of malignant transformation in oral mucosa.
    Clin Oral Investig 2016 Sep 8. Epub 2016 Sep 8.
    Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
    Background: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common tumor entity worldwide. Unfortunately, the multimodal treatment consisting of surgery, radiation, and chemotherapy does not show the desired efficacy. The intent of this study was to evaluate the sensitivity and specificity of an oral brush biopsy in combination with glucose transporter (GLUT)-1 staining in identifying premalignant and malignant lesions. Read More

    p53 and ki67 as biomarkers in determining response to chemoprevention for oral leukoplakia.
    J Oral Pathol Med 2016 Sep 8. Epub 2016 Sep 8.
    Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Japan.
    Background: We performed a randomized controlled chemoprevention trial of oral leukoplakia by administrating a low dose of beta-carotene and vitamin C supplements. 17% of subjects in the experimental arm (4/23) demonstrated clinical remission (complete or partial response) at completion of the trial. The objective of this study was to determine whether baseline expression of p53 and ki67 demonstrated any differences between those responding or not responding to our intervention. Read More

    Inter- and intra-observer variability in three grading systems for oral epithelial dysplasia.
    J Oral Maxillofac Pathol 2016 May-Aug;20(2):261-8
    Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Center, Bengaluru, India.
    Background And Objectives: Management of oral premalignant lesions depends on clinical assessment and grading of oral epithelial dysplasia (OED), which remains one of the most important predictors of malignant potential. Numerous grading systems for OED exists with varying sets of assessing criteria and are largely considered subjective. The present study attempted to assess the inter- and intra-observer variability in three grading systems: Binary system, WHO (2005) and Ljubljana systems. Read More

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