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    Systemic and topical photodynamic therapy (PDT) on oral mucosa lesions: an overview.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):123-126
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    Photodynamic Therapy (PDT) is a minimally invasive treatment that has shown promising results in treating preneoplasticlesions. PDT reckons on the administration of a drug (photosensitizer), which can be used in a topical or systemic form. Photodynamic therapy has been successfully used in the management of a variety of pathologies from different anatomical sites, including the head, neck, brain and lungs, hepatobiliary tree and other gastrointestinal and urological pathologies, skin, gynaecological conditions and in vascular anomalies. Read More

    Prevalence of HIV-related oral manifestations and their association with HAART and CD4+ T cell count: a review.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):51-59
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
    HIV infection is one of the major health problem of the last decades. This disease causes a chronic infection that can lead to acquired immunodeficiency syndrome (AIDS). According to the Global AIDS update, released in 2016 by HIV department of World Health Organization (WHO) and by the Joint United Nations Program on HIV/AIDS (UNAIDS), at the end of 2015, 36. Read More

    Assessing Oral Cancer Awareness Among Dental Students.
    J Cancer Educ 2018 Feb 14. Epub 2018 Feb 14.
    Faculty of Dentistry, Department of Oral Diagnosis and Maxillofacial Radiology, Marmara University, Başıbüyük Sağlık Yerleşkesi Başıbüyük Yolu 9/3 Maltepe, 34854, Istanbul, Turkey.
    The aim of this study was to assess oral cancer awareness among undergraduate dental students in Marmara University Faculty of Dentistry. A validated questionnaire which tested oral cancer awareness was given to third- and fifth-year students of the dental faculty of Marmara University. A total of 198 students participated in this survey. Read More

    Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment.
    Medicine (Baltimore) 2018 Feb;97(7):e9932
    Department of Gynecology, Cancer Institute Hospital.
    Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed. Read More

    Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma.
    Oncol Rep 2018 Feb 7. Epub 2018 Feb 7.
    Department of General Dentistry, The Ninth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200000, P.R. China.
    Oral leukoplakia (OL) is one of the most common oral precancerous lesions with the possibility of malignant transformation, ranging from 17 to 24% of patients with a median follow-up of >7 years. Previous research has revealed that compared with normal oral epithelial tissues, the expression of secretory leukocyte peptidase inhibitor (SLPI) protein is significantly reduced in oral squamous cell carcinoma (OSCC). Based on the above-mentioned research, it is known that SLPI is a potential predictive and diagnostic tool for the progression of oral carcinogenesis. Read More

    Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line.
    Oncol Lett 2018 Mar 19;15(3):3350-3356. Epub 2017 Dec 19.
    Department of Oral Biochemistry, Asahi University School of Dentistry, Mizuho, Gifu 501-0296, Japan.
    To elucidate the genetic events that occur during the development of OSCC, the present study established a model of oral malignancy using a mouse oral squamous cell carcinoma (OSCC) Sq-1979 cell line. Sq-1979 cells were implanted into syngeneic C3H mice. Subsequently, 233 cells and metastatic sub-clones (L cells) from primary OSCC, as well as the metastasized lymph node tissues of Sq-1979-implanted mice were established. Read More

    Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.
    J Formos Med Assoc 2018 Feb 7. Epub 2018 Feb 7.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    A Retrospective 20-Year Analysis of Proliferative Verrucous Leukoplakia and Its Progression to Malignancy and Association with High-risk Human Papillomavirus.
    Head Neck Pathol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.
    Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The aim of this study was to evaluate the malignant potential of PVL and determine its possible association with high-risk human papillomavirus (HPV). Twenty cases with a clinical and biopsy proven diagnosis of PVL were collected from the University of Florida Oral Medicine clinic database. Read More

    Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma.
    J Clin Exp Dent 2017 Dec 1;9(12):e1418-e1424. Epub 2017 Dec 1.
    Associate Professor, Department of Oral and Maxillofacial Pathology PMS College of Dental Science and Research, Thiruvananthapuram, Kerala, India.
    Background: Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim of our study was to compare the expression of podoplanin in oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma with that in normal buccal mucosa by immunohistochemical methods. Read More

    Oral Brush Liquid-Based Cytology: A Study of Concordance between a Cytotechnologist and a Cytopathologist.
    Acta Cytol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, India.
    Objective: Oral cancer accounts for almost 40% of all cancers in the Indian subcontinent. Techniques like oral scrape cytology are helpful in early diagnosis of premalignant lesion and thus prevention of malignant transformation. The purpose of this study is to evaluate the performance of cytotechnologists in assessing the adequacy and preliminary diagnostic accuracy of oral brush liquid-based cytology. Read More

    High HPV16 E6 viral load in the oral cavity is associated with an increased number of bacteria: A preliminary study.
    Biomed Rep 2018 Jan 29;8(1):59-64. Epub 2017 Nov 29.
    Department of Oral and Maxillofacial Surgery, Program of Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
    In a previous study, the present research group reported that males had a significantly higher prevalence of human papillomavirus (HPV)16 than females in oral rinse samples. The objective of the present study was to examine the relationship between HPV16 viral load and clinical factors, including remaining teeth, denture use and numbers of oral bacteria. A total of 124 patients (48 males and 76 females; mean age, 61. Read More

    Oral potentially malignant disorders: risk of progression to malignancy.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    UWA Dental School, The University of Western Australia, Nedlands, Australia.
    Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Read More

    Historical perspective and nomenclature of potentially malignant or potentially premalignant oral epithelial lesions with emphasis on leukoplakia-some suggestions for modifications.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    VU University Medical Center (VUmc)/Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam, The Netherlands. Electronic address:
    Of the potentially (pre)maligant oral epithelial lesions, leukoplakia is the most common. A brief overview of the various definitions of leukoplakia that have been used in the past is presented here. A proposal has been made to modify the current definition. Read More

    Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):456-457
    Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.
    Context: The malignant transformation potential of oral lichen planus (OLP) and related lesions is a subject of great controversy.

    Aim: The aim of this study was to compare the expression of proteins related to apoptosis and tumour suppressor gene processes in OLP, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD).

    Materials And Methods: The immunohistochemical study was carried out to investigate the expressions of survivin and p53 in a total of 30 lesional biopsy specimens - 10 cases each of OLP, OLR and OLD. Read More

    Quantitative and qualitative assessment of argyrophilic nucleolar organizer regions in normal, premalignant and malignant oral lesions.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):360-366
    Department of Oral Pathology, College of Dental Sciences and Research Bopal Dental College, Ahmedabad, Gujarat, India.
    Aim: The aim of the study was to assess the cell proliferation and biologic aggressiveness of the lesions by evaluating the significance of number and dispersal pattern of Argyrophillic Nucleolar organizing Regions (AgNORs) using silver colloid technique in normal mucosa, premalignant and malignant lesions.

    Settings And Design: In-vitro study, lab setting.

    Methods And Material: The study sample consisted of five groups each with a sample size of 10 and a control group. Read More

    The 150 most important questions in cancer research and clinical oncology series: questions 86-93 : Edited by Chinese Journal of Cancer.
    • Authors:
    Chin J Cancer 2018 Jan 22;37(1). Epub 2018 Jan 22.
    Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which spark diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 8 more questions are presented as follows. Question 86. Read More

    Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia.
    J Oral Pathol Med 2018 Jan 18. Epub 2018 Jan 18.
    INSERM 1052, CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
    Background: Oral squamous cell carcinoma is a major cause of cancer-associated morbidity and mortality and may develop from oral erythroplakia and leukoplakia (OEL), the most common oral potentially malignant lesions. Our objective was to provide a descriptive overview of the global research activity on OEL over the past decades.

    Methods: We performed a systematic bibliometric analysis of articles and reviews on OEL up to December 31st 2016 using the SCOPUS database. Read More

    Proliferative leukoplakia: proposed new clinical diagnostic criteria.
    Oral Dis 2018 Jan 16. Epub 2018 Jan 16.
    Division of Oral Medicine and Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA, USA.
    Objective: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathologic standpoint and suggest an updated classification.

    Subjects And Methods: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathologic features, and malignant transformation (MT).

    Results: There were 42 patients (median age: 69 years [range:36-88]; 35 females). Read More

    Association between clinical stage of oral cancer and expression of immunohistochemical markers.
    Pol Przegl Chir 2017 Dec;89(6):17-22
    Chair and Department of Oral Surgery, Medical University of Lublin, Poland.
    Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease.

    Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. Read More

    Oral lesions associated with human immunodeficiency virus in 75 adult patients: a clinical study.
    J Korean Assoc Oral Maxillofac Surg 2017 Dec 26;43(6):388-394. Epub 2017 Dec 26.
    Department of Oral Medicine and Diagnosis, School of Dentistry, Lebanese University, Beirut, Lebanon.
    Objectives: The objective of this study was to investigate the presence of oral lesions in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients in a descriptive cross-sectional study, and to establish their presence according to levels of CD4+ cells (including the CD4+/CD8+ cell ratio).

    Materials And Methods: A total of 75 patients infected with HIV were included. Oral lesions were observed and classified using World Health Organization classification guidelines. Read More

    Dysplasia Should Not Be Ignored in Lichenoid Mucositis.
    J Dent Res 2018 Jan 1:22034517748639. Epub 2018 Jan 1.
    1 Faculty of Dentistry, the University of British Columbia, Vancouver, BC, Canada.
    Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. Read More

    Considerations in the diagnosis of oral hairy leukoplakia-an institutional experience.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 15;125(3):232-235. Epub 2017 Nov 15.
    Department of Diagnostic Sciences, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Objective: We report here the 10-year experience with oral hairy leukoplakia (OHL) at the Division of Oral and Maxillofacial Pathology at the University of North Carolina at Chapel Hill, NC, USA.

    Study Design: All the associated hematoxylin and eosin and Epstein-Barr virus encoding region in situ hybridization slides of OHL cases between January 1, 2008, and February 1, 2017, were retrieved and reviewed. Collected demographic characteristics, clinical presentation, medical and social histories were reviewed and reported. Read More

    Uncovering the potential of CD44v/SYNE1/miR34a axis in salivary fluids of oral cancer patients.
    J Oral Pathol Med 2018 Jan 8. Epub 2018 Jan 8.
    Department of Life Sciences, School of Sciences, Gujarat University, Gujarat, India.
    Objectives: Late-stage diagnosis is one of the major confounders for poor prognosis of patients with oral cancer owing to lack of a biomarker to diagnose this disease at an early stage. Moreover, till date, invasive biopsies are the only option to assess disease occurrence and progression in this malignancy. Thus, this study aims to identify and assess potential salivary markers in OSCC patients in order to open newer avenues in the field of non-invasive biopsies. Read More

    p53 Codon 72 Gene Polymorphism Studies and p53 Expression by Immunohistochemistry in Oral Lesions as Risk Factor for Malignancy.
    Int J Appl Basic Med Res 2017 Oct-Dec;7(4):243-246
    Department of Surgical Oncology, K. G. Medical University, Lucknow, Uttar Pradesh, India.
    Background: Wild-type p53 nuclear phosphoproteins are critical cell cycle regulatory tumor-suppressor gene. Genetic mutation of p53 gene is common in several head-neck cancers, usually associated with smoking and human papillomavirus (HPV) infection. In India, instead of HPV, tobacco/pan masala chewing is more commonly associated with oral cancer. Read More

    Liaison between Heme Metabolism and Bioenergetics Pathways-A Multimodal Elucidation for Early Diagnosis of Oral Cancer.
    Photodiagnosis Photodyn Ther 2018 Jan 4. Epub 2018 Jan 4.
    Centre for Healthcare Science and Technology, Indian Institute of Engineering of Science and Technology Shibpur, Howrah, 711103, India. Electronic address:
    Metabolic alterations of oral epithelial cells under oxidative stress are important signatures for early diagnosis of oral cancer. Amongst different metabolic alterations, non-invasive photo-diagnostic methods have been extensively used for determining cellular heme metabolism and accumulation of protoporphyrin IX (PpIX) under administration of suitable photosensitizer. In this study, we report these metabolic alterations by direct analysis of oral exfoliated cells obtained from individuals with prolonged smoking habit without the exogenous administration of any photosensitizer. Read More

    Determinants of Tobacco Use and Prevalence of Oral Precancerous Lesions in Cab Drivers in Bengaluru City, India.
    Int J Prev Med 2017 5;8:100. Epub 2017 Dec 5.
    Department of Public Health Dentistry, KLE Institute of Dental Sciences, Bengaluru, Karnataka, India.
    Background: Tobacco is a most important risk factor for various types of cancer as well as some noncommunicable disease. Around 34.6% of Indian population consume tobacco. Read More

    Immunohistochemical Expression Of Ezrin In Oral Potentially Malignant Disorders-A Descriptive Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S205-S210
    Department of Oral Pathology and Microbiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
    Introduction: Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Read More

    Rapid detection of Candida albicans in oral exfoliative cytology samples by loop-mediated isothermal amplification.
    J Oral Sci 2017 ;59(4):541-547
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry.
    Loop-mediated isothermal amplification (LAMP) rapidly amplifies DNA under isothermal conditions. The aim of this study was to detect Candida albicans and compare the positivity rate in the LAMP reaction with that of conventional methods for oral exfoliative cytology (EC) samples. Sixty-eight EC samples from 53 patients were subjected to LAMP analysis. Read More

    A clinical diagnosis of oral leukoplakia; A guide for dentists.
    Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e59-e64. Epub 2018 Jan 1.
    VU medical center/ ACTA, dept. of Oral and Maxillofacial Surgery/Pathology P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands,
    Background: In view of the many white or predominantly white lesions of the oral mucosa it is a challenge for dentists to clinically identify a leukoplakia, being a potentially (pre)malignant lesion.

    Material And Methods: Based on the available literature and experience of the authors the parameters of a clinical diagnosis of oral leukoplakia have been studied.

    Results: A guide has been presented that should help dentists to establish a clinical diagnosis of leukoplakia as accurate as possible. Read More

    The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for, andSpecies.
    Front Microbiol 2017 1;8:2391. Epub 2017 Dec 1.
    Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.
    Oral leukoplakia presents as a white patch on the oral mucosa and is recognized as having significant malignant potential. Although colonization of these patches withis common, little is known about the bacterial microbiota of these patches. In the current study we analyzed the microbiome of oral leukoplakia in 36 patients compared to healthy mucosal tissue from the same patients and healthy control subjects to determine if specific microbial enrichments could be identified early in the malignant process that could play a role in the progression of the disease. Read More

    "Omics" in oral cancer: New approaches for biomarker discovery.
    Arch Oral Biol 2018 Mar 8;87:15-34. Epub 2017 Dec 8.
    School of Medical Science and Technology, IIT Kharagpur, India. Electronic address:
    Objectives: In this review paper, we explored the application of "omics" approaches in the study of oral cancer (OC). It will provide a better understanding of how "omics" approaches may lead to novel biomarker molecules or molecular signatures with potential value in clinical practice. A future direction of "omics"-driven research in OC is also discussed. Read More

    Gingival fibroma versus verrucous leukoplakia - A clinical dilemma!!!
    J Indian Soc Periodontol 2016 Nov-Dec;20(6):635-637
    Department of Periodontics, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India.
    Gingival overgrowths found in the oral cavity are mostly due to reactive hyperplasia and rarely depict neoplastic nature. It is a challenge for the clinician to give final diagnoses of gingival overgrowth. Gingiva is a common site for various benign and malignant lesions. Read More

    Revisiting lip shave: a solution for disorders of the vermilion border.
    Br J Oral Maxillofac Surg 2018 Jan 6;56(1):60-63. Epub 2017 Dec 6.
    Maxillofacial Unit, Poole Hospital NHS Trust, Dorset BH15 2JB, UK.
    Actinic keratosis, leukoplakia, carcinoma in situ, and superficially invasive carcinomas of the lower lip are caused mainly by the cumulative effects of exposure of the vermilion of the lower lip to ultraviolet radiation. Current treatments all have limitations: cryosurgery or electrosurgery is suitable to treat only focal lesions; topical chemotherapy, which is an option for diffuse actinic damage, yields unreliable results; and laser treatment fails to rejuvenate the vermilion. However, "lip shave", which involves full-thickness excision of the damaged vermilion and reconstruction with an advancement labial mucosal flap, will produce a fresh mucosal lining to the vermilion border. Read More

    Micronucleus Assay: An Early Diagnostic Tool to Assess Genotoxic Changes in Patients with Tobacco Use, Oral Leukoplakia and Oral Submucous Fibrosis.
    J Clin Diagn Res 2017 Sep 1;11(9):ZC28-ZC32. Epub 2017 Sep 1.
    Medical Research Scientist, Jorhat Medical College and Hospital, Barbheta, Jorhat, Assam, India.
    Introduction: Micronuclei (MNi) are acentric chromatid or chromosome fragments produced via genetic damage through genotoxic agents contained in tobacco and betel nut. Evidently, the various Oral Potentially Malignant Disorders (OPMDs) like oral lichen Planus, oral leukoplakia and Oral Submucous Fibrosis (OSMF) demonstrate MNi, as a substantiation of genetic damage. As these changes can be easily appreciated in oral exfoliated cells, an exfoliated cell based MNi assay might be utilized as handy and non invasive biomonitoring tool for gauging the genetic damage and hence the propensity for malignant transformation in OPMDs. Read More

    Status of Serum and Salivary Ascorbic Acid in Oral Potentially Malignant Disorders and Oral Cancer.
    Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):306-310
    Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India.
    Background And Aims: The aim of this study was to estimate the detoxification status of serum and saliva by assessing the serum and salivary Vitamin C in oral potentially malignant disorders and oral cancer.

    Subjects And Methods: A total of 90 subjects, 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls) were included in the study. Serum and saliva were collected and levels of Vitamin C were assessed. Read More

    Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma.
    Appl Immunohistochem Mol Morphol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São José dos Campos, São Paulo State University (Unesp).
    Oral potentially malignant disorders (OPMD) may develop malignant characteristics and transform into oral squamous cell carcinoma (OSCC) in a range of 1% to 2% of cases. Chronic alcohol consumption is associated with carcinogenesis, but its mechanism has not yet been fully elucidated. ALDH1A1 and 2, isoenzymes responsible for aldehyde oxidation involved in ethanol metabolism may be associated with the development of malignant head and neck neoplasms. Read More

    White oral mucosal lesions among the Yemeni population and their relation to local oral habits.
    J Investig Clin Dent 2017 Nov 26. Epub 2017 Nov 26.
    Department of Oral Medicine, Sana'a University, Sana'a, Yemen.
    Aims: The aim of the present study was to assess the prevalence and risk factors of white oral mucosal lesions among Yemeni adults; in particular, those who chew khat and tobacco.

    Methods: The present cross-sectional study included 1052 dental patients aged 15 years and older. A detailed oral examination was performed by a single examiner in accordance with standard international criteria. Read More

    Carcinogenic potential of sanguinarine, a phytochemical used in 'therapeutic' black salve and mouthwash.
    Mutat Res 2017 Oct 6;774:46-56. Epub 2017 Sep 6.
    Southern Cross Plant Science, Southern Cross University, Lismore, NSW, Australia. Electronic address:
    Black salves are escharotic skin cancer therapies in clinical use since the mid 19th century. Sanguinaria canadensis, a major ingredient of black salve formulations, contains a number of bioactive phytochemicals including the alkaloid sanguinarine. Despite its prolonged history of clinical use, conflicting experimental results have prevented the carcinogenic potential of sanguinarine from being definitively determined. Read More

    Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats.
    Psychoneuroendocrinology 2017 Nov 8. Epub 2017 Nov 8.
    Psychoneuroimmunology Research Center, Oral Oncology Center, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St., SP 15050-015, Araçatuba, São Paulo, Brazil; Department of Pathology and Clinical Propedeutics, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St., SP 15050-015, Araçatuba, São Paulo, Brazil. Electronic address:
    Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction. Read More

    Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia.
    J Korean Assoc Oral Maxillofac Surg 2017 Oct 26;43(5):324-330. Epub 2017 Oct 26.
    Department of Oral Pathology, Vaidik Dental College, Daman, India.
    Objectives: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63 expression in leukoplakia and OSCC to investigate the possible correlation of both markers with grade of dysplasia and histological grade of OSCC.

    Materials And Methods: The study included a total of 60 cases, of which 30 were diagnosed with OSCC and 30 with leukoplakia, that were evaluated immunohistochemically for p63 and cyclin D1 expression. Read More

    Raman exfoliative cytology for oral precancer diagnosis.
    J Biomed Opt 2017 Nov;22(11):1-12
    Tata Memorial Center, Advanced Center for Treatment, Research and Education in Cancer, Chilakapati L, India.
    Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). Read More

    Evaluation and Management of Oral Potentially Malignant Disorders.
    Dent Clin North Am 2018 Jan 18;62(1):1-27. Epub 2017 Oct 18.
    Department of Oral and Maxillofacial Pathology, Radiology and Medicine, NYU College of Dentistry, 345 East 24th Street, New York, NY 10010, USA.
    Oral potentially malignant disorders (OPMDs) refer to epithelial lesions and conditions with an increased risk for malignant transformation; oral leukoplakia is the most commonly encountered. Overall, OPMDs have a low risk for malignant transformation, yet the challenge is the difficulty to reliably identify and predict which patients with OPMDs are at the highest risk for malignant transformation. Future research is needed to elucidate the molecular aspects of OPMDs, to improve current diagnostic strategies, leading to personalized management. Read More

    Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio.
    Int J Oral Sci 2017 Nov 10;9(11):e2. Epub 2017 Nov 10.
    Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
    The autofluorescence visualization method (AVM) uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss (FVL). In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Read More

    T cells are involved in the induction of macrophage phenotypes in oral leukoplakia and squamous cell carcinoma-a preliminary report.
    J Oral Pathol Med 2018 Feb 19;47(2):136-143. Epub 2017 Nov 19.
    Department of Pathomorphology, Medical University of Lodz, Lodz, Poland.
    Background: The prognosis of human malignancies has been shown to depend on immunological parameters, such as macrophage polarization (M1 and M2). In this study, we identify the phenotype of macrophages, and investigate an involvement of infiltrated T cells that participate in the polarization of macrophages, in oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC).

    Methods: Immunohistochemical method was used to examine the number of CD68, CD163(M2), iNOS(M1) macrophages, and CD4, CD8, CCR4(Th2), CCR5(Th1) cells in 102 cases of OSCC: without metastases-OSCC M(-) (n = 54), and with metastases-OSCC M(+) (n = 48), 23 cases of OLK, and 18 control cases. Read More

    Oral leukoplakia and proliferative verrucous leukoplakia: a review for dental practitioners.
    Br Dent J 2017 Dec 3;223(9):655-661. Epub 2017 Nov 3.
    Oral Medicine, Bristol Dental Hospital and School, Lower Maudlin Street, Bristol, BS1 2LY, United Kingdom.
    Objectives To provide an overview of the current thinking in terms of the diagnosis and management of oral leukoplakia and proliferative verrucous leukoplakia as relevant to general dental practitioners.Data sources, data selection, data extraction, data synthesis We searched the MEDLINE Ovid, EMBASE databases and the Cochrane Library, (1990 to 16 April 2017), restricting our search to English language with the following key words: leukoplakia, white patch, proliferative verrucous leukoplakia, precancerous lesion, premalignant lesions, potentially malignant oral conditions and potentially malignant oral disorders. The two authors selected key papers and engaged in collaborative data extraction and synthesis of the selected reference material. Read More

    Clinical heterogeneity in a family withmutation, dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome in first cousins.
    Pediatr Rep 2017 Oct 6;9(3):7301. Epub 2017 Oct 6.
    Unit of Pediatrics, Castelli Hospital, Verbania.
    Dyskeratosis congenita (DC) is an inherited bone marrow failure disorder characterized by mucocutaneous features (skin pigmentation, nail dystrophy and oral leukoplakia), pulmonary fibrosis, hematologic and solid malignancies. Its severe form, recognized as Hoyeraal-Hreidarsson syndrome (HHS), also includes cerebellar hypoplasia, microcephaly, developmental delay and prenatal growth retardation. In literature phenotypic variability among DC patients sharing the same mutation is wellknown. Read More

    Limited evidence for interventions to treat oral leukoplakia.
    Evid Based Dent 2017 10;18(3):92-93
    New York University College of Dentistry, New York, USA.
    Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase, Ovid, CancerLit via PubMed. MetaRegister of Controlled Trials, and the WHO International Clinical Trials Registry Platform were searched for ongoing trials. Read More

    Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts.
    Chem Res Toxicol 2017 Dec 15;30(12):2159-2164. Epub 2017 Nov 15.
    Department of Medicine, Medical College of Wisconsin , Milwaukee, Wisconsin 53226, United States.
    Black raspberries (BRB) have been shown to inhibit carcinogenesis in a number of systems, with most studies focusing on progression. Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo-[a,l]-pyrene dihydrodiol (DBP-diol)-induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Here we extend this work to protection by BE against DNA adduct formation induced by dibenzo-[a,l]-pyrene (DBP) in a human oral leukoplakia cell line (MSK) and to a second carcinogen, UV light. Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    Oral Lesions in Kidney Transplant Recipients
    Acta Clin Croat 2016 09;55(3):459-463
    Clinical Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia
    Permanent immunosuppression is necessary to prevent rejection after kidney transplantation. However, it may predispose patients to different conditions and diseases including oral lesions. The most common benign oral lesions in kidney transplant recipients are gingival hyperplasia, oral candidiasis, hairy leukoplakia and saburral tongue. Read More

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