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    Patterns of tobacco usage among subjects with potentially malignant oral lesions or conditions in Chennai city: A comparative study.
    J Cancer Res Ther 2017 Apr-Jun;13(2):230-234
    Department of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
    Objective: To determine the patterns of tobacco usage among subjects with potentially malignant oral lesions or conditions through a comparative study design.

    Methods: The study was carried out in a span of 2 months on a sample of 120 subjects; 60 in case group (30 subjects with leukoplakia and oral submucous fibrosis [OSMF], respectively) and 60 subjects in control group (30 current smokers and current chewers, respectively), attending the tobacco cessation clinic at a private dental college hospital in Chennai city. Demographic data, details of tobacco usage, and Fagerstrom nicotine dependence scores (FNTD) were recorded in a prevalidated tobacco cessation intake form. Read More

    Management of proliferative verrucous leukoplakia: Justification for a conservative approach.
    Head Neck 2017 Jun 22. Epub 2017 Jun 22.
    Mersey Head and Neck Oncology Research Group (MHNORG), Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
    Background: Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic.

    Method: Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Read More

    A comparative evaluation: Oral leukoplakia surgical management using diode laser, CO2 laser, and cryosurgery.
    J Clin Exp Dent 2017 Jun 1;9(6):e779-e784. Epub 2017 Jun 1.
    Post Graduate Student , Department of Oral and Maxillofacial Surgery, Dayananda Sagar College of Dental Sciences.
    Background: The comparatively evaluate the three surgical treatment modalities namely cryosurgery, diode and CO2 laser surgery in terms of healing outcomes on the day of surgery, first and second week post operatively and recurrence at the end of 18 months was assessed.

    Material And Methods: Thirty selected patients were divided randomly into three groups. Each group comprising of ten patients were subjected to one of the three modalities of treatment namely cryosurgery, diode laser or CO2 laser surgery for ablation of OL. Read More

    [Surgical treatment of patients with oral leukoplakia].
    Stomatologiia (Mosk) 2016 ;95(5):53-60
    Central Research Institute of Dentistry and Maxillofacial Surgery Moscow, Russia.
    The aim of the study was to elaborate lingual nerve sparing procedure of submandibular gland duct stones extraction. The study involved 43 patients with syalolithiasis treated in Oral Surgery Unit of Central Research Institute of Dentistry and Maxillofacial Surgery in 2013-2015. It was shown that to prevent lingual nerve and artery injury submandibular salivary gland duct should be dissected to the level of obstruction thus allowing adequate visualization of anatomical correlations especially when removing stones from the distal part of the duct. Read More

    Immunosurveillance profile of oral squamous cell carcinoma and oral epithelial dysplasia through dendritic and T cells analysis.
    J Oral Pathol Med 2017 Jun 5. Epub 2017 Jun 5.
    Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
    Oral squamous cell carcinomas (OSCC) can arise from potentially malignant disorders, such as leukoplakia. The immune system plays an important role recognizing tumour precursor cells. However, due to immunoediting mechanisms cancer cells are able to escape immune system surveillance. Read More

    Expression of Human Papillomavirus DNA and p53 Polymorphisms through Polymerase Chain Reaction in Normal Mucosa and Oral Leukoplakia Individuals with Deleterious Oral Habits.
    Int J Appl Basic Med Res 2017 Apr-Jun;7(2):134-138
    Department of Oral Pathology and Microbiology, GITAM Dental College, Visakhapatnam, Andhra Pradesh, India.
    Context: Oral leukoplakia (OL) is a well-recognized precancerous lesion with various etiological factors. Most commonly deleterious oral habits such as tobacco smoking and viral etiologies mainly human papillomavirus (HPV) play an important role. p53 polymorphisms mostly homozygous Arginine (Arg) allele has a greater risk of degradation by HPV. Read More

    In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia.
    Cell Death Discov 2017 22;3:17022. Epub 2017 May 22.
    Department of Otolaryngology-Head and Neck Cancer Research, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
    A subset of patients with oral squamous cell carcinoma (OSCC), the most common subtype of head and neck squamous cell carcinoma (HNSCC), harbor dysplastic lesions (often visually identified as leukoplakia) prior to cancer diagnosis. Although evidence suggest that leukoplakia represents an initial step in the progression to cancer, signaling networks driving this progression are poorly understood. Here, we applied in silico Pathway Activation Network Decomposition Analysis (iPANDA), a new bioinformatics software suite for qualitative analysis of intracellular signaling pathway activation using transcriptomic data, to assess a network of molecular signaling in OSCC and pre-neoplastic oral lesions. Read More

    Plasma HPV DNA is detectable in oral leukoplakia patients.
    Pathol Res Pract 2017 Jul 20;213(7):759-765. Epub 2017 Apr 20.
    Oral Oncology Center and Department of Pathology and Clinical Propaedeutics, Araçatuba School of Dentistry, São Paulo State University (UNESP - Univ Estadual Paulista), Araçatuba, São Paulo, 16015-050, Brazil.
    Background: Oral leukoplakia is considered a potentially malignant lesion for the development of squamous cell carcinoma, and various risk factors may be related to its development and malignant transformation, including the human papillomavirus (HPV). The aim of this case-control study was to detect the presence of HPV in fresh tissue, plasma and saliva samples obtained from patients with and without oral leukoplakia, and verify the correlation of the presence of DNA of HPV between different sources of materials.

    Methods: In this study, 32 patients with oral leukoplakia and 24 patients selected in a case-control manner were included. Read More

    Quantitative prediction of oral cancer risk in patients with oral leukoplakia.
    Oncotarget 2017 May 2. Epub 2017 May 2.
    Department of Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
    Exfoliative cytology has been widely used for early diagnosis of oral squamous cell carcinoma. We have developed an oral cancer risk index using DNA index value to quantitatively assess cancer risk in patients with oral leukoplakia, but with limited success. In order to improve the performance of the risk index, we collected exfoliative cytology, histopathology, and clinical follow-up data from two independent cohorts of normal, leukoplakia and cancer subjects (training set and validation set). Read More

    Interventions for treating oral leukoplakia to prevent oral cancer.
    Nurs Stand 2017 May;31(39):42-43
    South Brisbane, Australia, and Member of the Cochrane Nursing Care Field.
    The mission of the Cochrane Nursing Care Field (CNCF) is to improve health outcomes through increasing the use of the Cochrane Library and supporting Cochrane's role by providing an evidence base for nurses and healthcare professionals who deliver, lead or research nursing care. The CNCF produces Cochrane Corner columns, summaries of recent nursing-care-relevant Cochrane Reviews that are regularly published in collaborating nursing-related journals. Information on the processes CNCF has developed can be accessed at: cncf. Read More

    Exploring the mechanism of WWOX growth inhibitory effects on oral squamous cell carcinoma.
    Oncol Lett 2017 May 13;13(5):3198-3204. Epub 2017 Mar 13.
    School of Laboratory Medicine, Beihua University, Jilin City, Jilin 132013, P.R. China.
    Oral squamous cell carcinoma (OSCC) is one of the most common types of head and neck neoplasms in the world. Patients diagnosed with OSCC exhibit a poor prognosis. WW domain-containing oxidoreductase (WWOX), as a candidate tumor-suppressor gene, is involved in the genesis and progression of tumors. Read More

    Salivary biomarkers and proteomics: future diagnostic and clinical utilities.
    Acta Otorhinolaryngol Ital 2017 Apr;37(2):94-101
    Department of Head and Neck Surgery, "A. Gemelli" Hospital Foundation, Catholic University, Rome, Italy.
    Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 90% of proteins in weight are derived from the secretion of three couples of "major" glands; all the other components are derived from minor glands, gingival crevicular fluid, mucosal exudates and oral microflora. Read More

    A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells.
    Cell Rep 2017 May;19(7):1479-1493
    Division of Infectious Disease, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA; Harvard Virology Program, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:
    Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus-host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection. We quantified profiles of >8,000 cellular and 69 EBV proteins, including >500 plasma membrane proteins, providing temporal views of the lytic B cell proteome and EBV virome. Read More

    Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy-A cross-sectional study.
    Oral Dis 2017 May 17. Epub 2017 May 17.
    Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University, Vadodara, India.
    Objectives: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress lead to changes in certain antioxidants. This study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker.

    Material And Methods: The study population comprised of 300 participants, equally divided into six study groups, that is, oral submucous fibrosis (OSMF), oral leukoplakia (OL), nicotina stomatitis (NS), oral malignancy (OM), controls (C), and healthy controls (HC); 5 ml of blood was collected from ante cubital vein from each participant. Read More

    Evaluation of Total and Lipid Bound Sialic Acid in Serum in Oral Leukoplakia.
    J Clin Diagn Res 2017 Mar 1;11(3):ZC25-ZC27. Epub 2017 Mar 1.
    Professor and Head, Department of Oral Pathology and Microbiology, Meenakshi Ammal Dental College and Hospital, Chennai, India, Tamil Nadu.
    Introduction: Oral cancer has become the most common cause of cancer related mortality which may be preceded by oral potentially malignant disorders. Altered glycosylation of glycoconjugates, such as sialic acid are one of the most important molecular changes accompanied during malignant transformation in precancerous lesions like Oral Leukoplakia (OL), and correlating them histopathologically with grades of epithelial dysplasia which will serve clinical significance.

    Aim: The aim of this study was to evaluate the significance of serum Total Sialic Acid (TSA) and serum Lipid Bound Sialic Acid (LSA) as a prognostic serum marker in Oral Leukoplakia. Read More

    Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
    J Investig Clin Dent 2017 May 8. Epub 2017 May 8.
    Department of Conservative and Endodontics, HSRS Dental College and Hospital, Hingoli, Maharashtra, India.
    Aim: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially-malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).

    Methods: From 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded. Read More

    Leukoplakia of buccal mucosa with transformation into spindle cell carcinoma: A rare case report.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):119-123
    Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Spindle cell carcinoma (SpCC), a variant of squamous cell carcinoma, is a biphasic malignant neoplasm that occurs mainly in the upper aerodigestive tract. It is uncommon in oral cavity, accounting for <1% of all tumors in oral cavity. Furthermore, it is uncommon for oral potentially malignant disorders such as leukoplakia to undergo transformation into SpCC. Read More

    Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.
    Tumour Biol 2017 May;39(5):1010428317699113
    2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
    The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. Read More

    Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions.
    Oral Oncol 2017 May 18;68:36-43. Epub 2017 Mar 18.
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
    Objectives: Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transformation of oral precancerous lesions.

    Materials And Methods: Patients with oral precancerous lesions managed at the Nara Medical University Hospital, Japan, (n=120) were enrolled in this study. Read More

    The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma.
    J Oral Pathol Med 2017 Apr 24. Epub 2017 Apr 24.
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
    Objectives: To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues.

    Materials And Methods: A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia samples and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, oral leukoplakia and normal controls was evaluated by immunohistochemical assay. Read More

    Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.
    Transl Oncol 2017 Jun 21;10(3):396-409. Epub 2017 Apr 21.
    Cancer Research Institute (CRI), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India. Electronic address:
    We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and that several changes are associated with this progression, including amplification of 8q24.3, deletion of 8p23. Read More

    Evaluation of Different Laser-Supported Surgical Protocols for the Treatment of Oral Leukoplakia: A Long-Term Follow-Up.
    Photomed Laser Surg 2017 Apr 20. Epub 2017 Apr 20.
    3 Unit of Oral Pathology and Medicine and Laser-assisted Oral Surgery, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, Faculty of Medicine and Surgery, University of Parma , Parma, Italy .
    Purpose: The aim of this study was to evaluate the long-term success rate of oral leukoplakia treatments by using different laser-supported surgical protocols.

    Patients And Methods: Overall, 2347 diagnosed homogeneous oral leukoplakias were treated with CO2 laser and were included in this study. Different surgical protocols (P) were used: P1 (SV = superficial scanning) was a complete superficial vaporization of the leukoplakia by a scanning mode in two passages respecting an overlapping. Read More

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

    Genetic changes in oral premalignant lesion, condition, and oral squamous cell carcinoma - A study based on inhibition of G2M phase by colchicines.
    Indian J Dent Res 2017 Jan-Feb;28(1):55-58
    Department of Oral Medicine and Radiology, Farooquia Dental College and Hospital, Mysore, Karnataka, India.
    Aims: To assess the percentage of cell arrested in G2M phase by colchicine in the early detection and prognosis of oral cancer, by comparison of oral squamous cell with leukoplakia and oral submucous fibrosis (OSMF) using flow cytometry analysis.

    Materials And Methods: Biopsy samples 5 each of clinically diagnosed and histopathologically confirmed case of leukoplakia, OSMF, and squamous cell carcinoma (SCC) are included in the study.

    Results: Colchicines significantly inhibited the growth of oral SCC-9 cell line by arresting G2M phase of the cell cycle (94. Read More

    Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.
    Med Oral Patol Oral Cir Bucal 2017 May 1;22(3):e297-e306. Epub 2017 May 1.
    University of Talca, Lircay Av. S/N, Talca, Chile, Zip code 3460000,
    Background: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce.

    Material And Methods: This study investigated the frequency of OD in a Chilean population. Read More

    Oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case.
    BMJ Case Rep 2017 Apr 6;2017. Epub 2017 Apr 6.
    Oral Medicine, University of Bristol Dental Hospital, Bristol, UK.
    Oral hairy leukoplakia (OHL) is an oral mucosal lesion that is associated with Epstein-Barr virus infection. It commonly presents as an asymptomatic, non-removable white patch on the lateral borders of the tongue in individuals who are immunocompromised. Historically, OHL was thought to be pathognomonic of HIV infection; however, it is now an established phenomenon in a range of conditions affecting immune competence. Read More

    Estimation of Serum Protein in Oral Potentially Malignant Disorders and Oral Malignancy - A Cross-Sectional Study.
    J Clin Diagn Res 2017 Feb 1;11(2):ZC17-ZC19. Epub 2017 Feb 1.
    Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University , Piparia, Vadodara, Gujarat, India .
    Introduction: In carcinogenesis, increased oxidative stress and weakened antioxidant defense produces damage to the macromolecules like proteins. Thus, protein can act as potential biomarker in oral premalignant and malignant lesions.

    Aim: To determine and compare the levels of serum proteins in Oral Submucuous Fibrosis (OSMF), Oral Leukoplakia (OL), Nicotina Stomatitis (NS), Oral Malignancy (OM) and Healthy Controls (HC). Read More

    Implication for second primary cancer from visible oral and oropharyngeal premalignant lesions in betel-nut chewing related oral cancer.
    Head Neck 2017 Jul 6;39(7):1428-1435. Epub 2017 Apr 6.
    Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, Taiwan.
    Background: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Read More

    Surgical management of chronic hyperplastic candidiasis refractory to systemic antifungal treatment.
    J Lab Physicians 2017 Apr-Jun;9(2):136-139
    Department of Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
    Chronic hyperplastic candidiasis (CHC), earlier known as candidal leukoplakia, is a variant of oral candidiasis that classically presents as a white patch on the commissures of the oral mucosa and it is mostly caused by Candida albicans. Clinically, the lesions are usually asymptomatic and regress after appropriate antifungal therapy and correction of the underlying cause. If the lesions are untreated, a small portion may develop dysplasia and later progress into carcinoma. Read More

    A Retrospective Evaluation of Partial Glossectomy for Early Tongue Cancer Using a Carbon Dioxide Laser.
    Photomed Laser Surg 2017 Mar 30. Epub 2017 Mar 30.
    1 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine , Kobe, Japan .
    Objective: The purpose of this study was to retrospectively evaluate the postoperative results of partial glossectomy for early tongue cancer using a carbon dioxide laser (CO2 laser).

    Background Data: CO2 lasers are frequently used for the excision or treatment of soft tissue in a range of diseases, including oral cancer, leukoplakia, mucocele, anomalies of the labial and lingual frenum, and peri-implantitis.

    Materials And Methods: We retrospectively reviewed 31 primary cases of early superficial tongue cancer that were treated using CO2 lasers. Read More

    Micronutrients and Their Role in Oral Cancer: A Review.
    West Indian Med J 2016 Mar 15;65(2):383-388. Epub 2016 Mar 15.
    Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.
    Cancer is one of the leading causes of death across the world. Oral cancer is the sixth most common type of cancer in the world. The incidence of oral cancer increases with the increase in the consumption of carcinogens such as tobacco and alcohol as seen in south and southeast Asia. Read More

    Topical agents for oral cancer chemoprevention: A systematic review of the literature.
    Oral Oncol 2017 Apr 2;67:153-159. Epub 2017 Mar 2.
    Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA; Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
    Objectives/hypothesis: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD).

    Methods: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence. Read More

    Predictive value of p63, ki-67, and survivin expression in oral leukoplakia: A tissue microarray study.
    Microsc Res Tech 2017 Mar 27. Epub 2017 Mar 27.
    Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Brazil.
    The aim of this study was to analyze the immunohistochemical expression of survivin, ki-67, and p63 in oral leukoplakic lesions, histopathologically differentiated into dysplastic and nondysplastic. A tissue microarray containing 57 samples of biopsies from clinically classified lesions, such as leukoplakia, was immunolabeled for survivin, ki-67, and p63. Samples were scored for percentage of positively stained. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Analysis of silver binding nucleolar organizer regions in exfoliative cytology smears of potentially malignant and malignant oral lesions.
    Biotech Histochem 2017 1;92(2):115-121. Epub 2017 Mar 1.
    e Department of Oral Medicine and Radiology , Pacific Dental College and Hospital , Udaipur , Rajasthan , India.
    Nucleolar organizer regions are nucleolar components that contain proteins that are stained selectively by silver methods; they can be identified as black dots throughout the nucleolus and are known as silver binding nucleolar organizer regions (AgNOR). The number of AgNOR is related to the cell cycle and the proliferative activity of the cells. We investigated AgNOR using exfoliative cytology smears of potentially malignant oral lesions. Read More

    Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study.
    J Oral Pathol Med 2017 Mar 14. Epub 2017 Mar 14.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Background: Oral submucous fibrosis (OSF) is one of the well-recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue.
    J Oral Pathol Med 2017 Mar 10. Epub 2017 Mar 10.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Morioka, Iwate, Japan.
    Background: Oral lichen planus (OLP) is a T-cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Read More

    Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population.
    J Maxillofac Oral Surg 2017 Mar 13;16(1):53-57. Epub 2016 May 13.
    Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.
    Aim: The aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).

    Materials And Methods: The study included 60 patients (15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of β2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Read More

    Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana.
    J Korean Assoc Oral Maxillofac Surg 2017 Feb 20;43(1):29-36. Epub 2017 Feb 20.
    Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
    Objectives: Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). People with AIDS are much more vulnerable to infections, including opportunistic infections and tumors, than people with a healthy immune system. The objective of this study was to correlate oral lesions associated with HIV/AIDS and immunosuppression levels by measuring clusters of differentiation 4 (CD4) cell counts among patients living in the middle western regions of Ghana. Read More

    Hospital-based epidemiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population.
    Int Dent J 2017 Mar 9. Epub 2017 Mar 9.
    Department of Oral Medicine, Peking University School and Hospital of Stomatology, National Engineer Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
    Objective: The aim of this review was to analyse, systematically, hospital-based epidemiological information concerning the malignant transformation rate (MTR) of oral leukoplakia (OL) in a Chinese population, as well as the associated risk factors.

    Methods: Four electronic databases were searched for studies dealing with OL and related risk factors, including age, gender, type of lesion, site, and smoking and drinking habits.

    Results: The MTR of OL in the hospital-based Chinese population ranged from 4% to 13%, based on the studies analysed. Read More

    Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study.
    Braz Oral Res 2017 03 6;31:e19. Epub 2017 Mar 6.
    Universidade Federal do Rio Grande do Sul - UFRGS, Department of Oral Pathology, Porto Alegre, RS, Brazil.
    To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with oral leukoplakia (n = 30) and oral squamous cell carcinoma (n = 22). Cell scrapings and the biopsy were performed at the site of the lesion and histological slides were prepared for the immunocytochemical analysis of exfoliated oral mucosal cells and for the immunohistochemical analysis of biopsy tissues using E-cadherin and involucrin. Read More

    Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma.
    Cancer Cell Int 2017 2;17:34. Epub 2017 Mar 2.
    Key laboratory of cell differentiation and apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Background: G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene inhibited the malignant phenotype in OSCC cells, suggesting that GPRC5A also functions as a tumor suppressor in oral cancer. However, the molecular mechanisms underlying GPRC5A deficiency in head and neck squamous cell carcinoma (HNSCC) are still unclear. Read More

    Environmental heavy metal as a potential risk factor for the progression of oral potentially malignant disorders in central Taiwan.
    Cancer Epidemiol 2017 Apr 2;47:118-124. Epub 2017 Mar 2.
    Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan. Electronic address:
    Objective: Oral cancer (OC) is a leading cause of death from cancer in men between the ages of 25 and 44 years in Taiwan. The overall 5-year survival rates for the four OC stages (I-IV) in Taiwan are approximately 70%, 30%, 20%, and 10%, respectively, indicating the importance of the early diagnosis of oral potentially malignant disorders (OPMDs). Previous studies indicated an association between the OC incidence and certain environmental heavy metal concentrations. Read More

    Knowledge, Attitude, and Practice of Women in Slums of Pimpri, Chinchwad, Pune, Maharashtra, India, regarding Usage of Mishri.
    J Contemp Dent Pract 2017 Mar 1;18(3):218-221. Epub 2017 Mar 1.
    Department of Public Health Dentistry, Shri. Yashwantrao Chavan Memorial Medical & Rural Development Foundation's Dental College & Hospital, Ahmednagar, Maharashtra, India.
    Introduction: Mishri is one of the form of smokeless tobacco, which is a roasted, powdered preparation made by baking tobacco on a hot metal plate until it is uniformly black, after which it is powdered. It is noted that mishri use is more commonly used by the women of low socioeconomic status, hence the need was felt to conduct this study among women mishri users of slums. Also, the consequences of mishri use are little known, hence an effort is made to find out its ill-effect on oral health. Read More

    Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.
    Cancer Med 2017 Apr 3;6(4):730-738. Epub 2017 Mar 3.
    Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
    Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)-β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. Read More

    Assessing Oral Cancer Awareness Among Dentists.
    J Cancer Educ 2017 Mar 1. Epub 2017 Mar 1.
    Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Marmara University, Güzelbahçe Büyükciftlik Sok. No:6 34365 Nişantaşı, İstanbul, Turkey.
    The aim of this study was to assess oral cancer awareness among dentists who attended 101st FDI World Dental Congress, İstanbul, Turkey. Among 170 dentists who agreed to participate, there were 13 oral surgeons, 6 restorative dentists, 4 endodontists, 4 orthodontists, 6 periodontists, 5 pedodontists, and 14 prosthodontists. Knowledge of oral cancer risk factors and diagnosis procedures, dentists' attitude towards oral cancers, management practice regarding oral cancer, and oral cancer information sources were assessed using 25 questions. Read More

    Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue.
    Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.
    Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.
    There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

    Betel nut chewing, oral premalignant lesions, and the oral microbiome.
    PLoS One 2017 22;12(2):e0172196. Epub 2017 Feb 22.
    University of Guam Cancer Research Center, Mangilao, Guam, United States of America.
    Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Read More

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