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    Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats.
    Psychoneuroendocrinology 2017 Nov 8. Epub 2017 Nov 8.
    Psychoneuroimmunology Research Center, Oral Oncology Center, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St., SP 15050-015, Araçatuba, São Paulo, Brazil; Department of Pathology and Clinical Propedeutics, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St., SP 15050-015, Araçatuba, São Paulo, Brazil. Electronic address:
    Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction. Read More

    Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia.
    J Korean Assoc Oral Maxillofac Surg 2017 Oct 26;43(5):324-330. Epub 2017 Oct 26.
    Department of Oral Pathology, Vaidik Dental College, Daman, India.
    Objectives: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63 expression in leukoplakia and OSCC to investigate the possible correlation of both markers with grade of dysplasia and histological grade of OSCC.

    Materials And Methods: The study included a total of 60 cases, of which 30 were diagnosed with OSCC and 30 with leukoplakia, that were evaluated immunohistochemically for p63 and cyclin D1 expression. Read More

    Raman exfoliative cytology for oral precancer diagnosis.
    J Biomed Opt 2017 Nov;22(11):1-12
    Tata Memorial Center, Advanced Center for Treatment, Research and Education in Cancer, Chilakapati L, India.
    Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). Read More

    Evaluation and Management of Oral Potentially Malignant Disorders.
    Dent Clin North Am 2018 Jan 18;62(1):1-27. Epub 2017 Oct 18.
    Department of Oral and Maxillofacial Pathology, Radiology and Medicine, NYU College of Dentistry, 345 East 24th Street, New York, NY 10010, USA.
    Oral potentially malignant disorders (OPMDs) refer to epithelial lesions and conditions with an increased risk for malignant transformation; oral leukoplakia is the most commonly encountered. Overall, OPMDs have a low risk for malignant transformation, yet the challenge is the difficulty to reliably identify and predict which patients with OPMDs are at the highest risk for malignant transformation. Future research is needed to elucidate the molecular aspects of OPMDs, to improve current diagnostic strategies, leading to personalized management. Read More

    Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio.
    Int J Oral Sci 2017 Nov 10;9(11):e2. Epub 2017 Nov 10.
    Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
    The autofluorescence visualization method (AVM) uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss (FVL). In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Read More

    T cells are involved in the induction of macrophage phenotypes in oral leukoplakia and squamous cell carcinoma-a preliminary report.
    J Oral Pathol Med 2017 Nov 6. Epub 2017 Nov 6.
    Department of Pathomorphology, Medical University of Lodz, Lodz, Poland.
    Background: The prognosis of human malignancies has been shown to depend on immunological parameters, such as macrophage polarization (M1 and M2). In this study, we identify the phenotype of macrophages, and investigate an involvement of infiltrated T cells that participate in the polarization of macrophages, in oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC).

    Methods: Immunohistochemical method was used to examine the number of CD68(+) , CD163(+) (M2), iNOS(+) (M1) macrophages, and CD4(+) , CD8(+) , CCR4(+) (Th2), CCR5(+) (Th1) cells in 102 cases of OSCC: without metastases-OSCC M(-) (n = 54), and with metastases-OSCC M(+) (n = 48), 23 cases of OLK, and 18 control cases. Read More

    Oral leukoplakia and proliferative verrucous leukoplakia: a review for dental practitioners.
    Br Dent J 2017 Dec 3;223(9):655-661. Epub 2017 Nov 3.
    Oral Medicine, Bristol Dental Hospital and School, Lower Maudlin Street, Bristol, BS1 2LY, United Kingdom.
    Objectives To provide an overview of the current thinking in terms of the diagnosis and management of oral leukoplakia and proliferative verrucous leukoplakia as relevant to general dental practitioners.Data sources, data selection, data extraction, data synthesis We searched the MEDLINE Ovid, EMBASE databases and the Cochrane Library, (1990 to 16 April 2017), restricting our search to English language with the following key words: leukoplakia, white patch, proliferative verrucous leukoplakia, precancerous lesion, premalignant lesions, potentially malignant oral conditions and potentially malignant oral disorders. The two authors selected key papers and engaged in collaborative data extraction and synthesis of the selected reference material. Read More

    Clinical heterogeneity in a family with DKC1 mutation, dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome in first cousins.
    Pediatr Rep 2017 Oct 6;9(3):7301. Epub 2017 Oct 6.
    Unit of Pediatrics, Castelli Hospital, Verbania.
    Dyskeratosis congenita (DC) is an inherited bone marrow failure disorder characterized by mucocutaneous features (skin pigmentation, nail dystrophy and oral leukoplakia), pulmonary fibrosis, hematologic and solid malignancies. Its severe form, recognized as Hoyeraal-Hreidarsson syndrome (HHS), also includes cerebellar hypoplasia, microcephaly, developmental delay and prenatal growth retardation. In literature phenotypic variability among DC patients sharing the same mutation is wellknown. Read More

    Limited evidence for interventions to treat oral leukoplakia.
    Evid Based Dent 2017 Oct;18(3):92-93
    New York University College of Dentistry, New York, USA.
    Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase, Ovid, CancerLit via PubMed. MetaRegister of Controlled Trials, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform were searched for ongoing trials. Read More

    Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts.
    Chem Res Toxicol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Medicine, Medical College of Wisconsin , Milwaukee, Wisconsin 53226, United States.
    Black raspberries (BRB) have been shown to inhibit carcinogenesis in a number of systems, with most studies focusing on progression. Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo-[a,l]-pyrene dihydrodiol (DBP-diol)-induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Here we extend this work to protection by BE against DNA adduct formation induced by dibenzo-[a,l]-pyrene (DBP) in a human oral leukoplakia cell line (MSK) and to a second carcinogen, UV light. Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    ORAL LESIONS IN KIDNEY TRANSPLANT RECIPIENTS.
    Acta Clin Croat 2016 09;55(3):459-63
    Permanent immunosuppression is necessary to prevent rejection after kidney transplantation. However, it may predispose patients to different conditions and diseases including oral lesions. The most common benign oral lesions in kidney transplant recipients are gingival hyperplasia, oral candidiasis, hairy leukoplakia and saburral tongue. Read More

    Ultrastructural Changes during the Life Cycle of Mycoplasma salivarium in Oral Biopsies from Patients with Oral Leukoplakia.
    Front Cell Infect Microbiol 2017 21;7:403. Epub 2017 Sep 21.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical UniversityShiwagun, Japan.
    Bacteria in genus Mycoplasma spp. are the smallest and simplest form of freely replicating bacteria, with 16 species known to infect humans. In the mouth, M. Read More

    Successful Second Unrelated Donor Hematopoietic Stem Cell Transplant in a Patient With Dyskeratosis Congenital After First Graft Rejection.
    Exp Clin Transplant 2017 Sep 30. Epub 2017 Sep 30.
    Stem Cell Transplantation Unit, Department of Pediatric Hematology and Oncology, Istituto Giannina Gaslini, Genoa, Italy.
    Dyskeratosis congenita is a rare congenital telomeropathy characterized by cutaneous and nail dystrophy, oral leukoplakia, and bone marrow failure. Pulmonary fibrosis and cancers are late manifestations. Allogeneic hematopoietic stem cell transplant represents the only cure for those with bone marrow failure with this disease, but outcomes reported are overall poor, with organ toxicities, graft failure, and graft-versus-host disease as main issues. Read More

    Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment.
    Contemp Oncol (Pozn) 2017 30;21(2):145-151. Epub 2017 Jun 30.
    King George's Medical University, India.
    Aim Of The Study: Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research.

    Material And Methods: Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). Read More

    [Oral cancer -diagnosis and therapy-.]
    Clin Calcium 2017;27(10):1427-1433
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Japan.
    Oral cancer is a malignant neoplasm that occurs in the oral cavity. Squamous cell carcinoma accounts for over 90%of the oral cancers, and others include adenocarcinoma derived from minor salivary gland, sarcoma, malignant lymphoma and metastatic cancer. The number of oral cancer patients in Japan is about 3-times higher than the current number. Read More

    Overexpression of immunomodulatory mediators in oral precancerous lesions.
    Hum Immunol 2017 Sep 21. Epub 2017 Sep 21.
    Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil. Electronic address:
    Human leukocyte antigen (HLA) G and E, programmed cell death 1 ligand 1 (PD-L1), IL-10 and TGF-β are proteins involved in failure of the antitumor immune response. We investigated the expression of these immunomodulatory mediators in oral precancerous lesions (oral leukoplakia-OL; n=80) and whether these molecules were related to the risk of malignant transformation. Samples of normal mucosa (n=20) and oral squamous cells carcinoma (OSCC, n=20) were included as controls. Read More

    Snail and Axin2 expression predict the malignant transformation of oral leukoplakia.
    Oral Oncol 2017 Oct 12;73:48-55. Epub 2017 Aug 12.
    Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, Republic of Korea. Electronic address:
    Objectives: Oral leukoplakia (OL) has a well-documented potential risk of malignant transformation into oral squamous cell carcinoma (OSCC), although biomarker(s) predicting malignant potential are limited in capability. The aim of this cross-sectional and retrospective cohort study was to investigate the predictive role of canonical Wnt genes Axin2 and Snail (SNAI1) expression in the malignant transformation of OL lesions.

    Materials And Methods: The expression of epithelial-mesenchymal transition (EMT) genes Snail and Axin2, which are regulated by the canonical Wnt pathway, were determined using immunohistochemical staining in an OL cohort consisting of 154 samples of patients with long-term follow-up and then evaluated as risk factors for malignant transformation of OL. Read More

    Mast cells and angiogenesis in malignant and premalignant oral lesions: An immunohistochemical study.
    J Oral Maxillofac Pathol 2017 May-Aug;21(2):229-238
    Department of Oral and Maxillofacial Pathology, V.S. Dental College and Hospital, Bengaluru, Karnataka, India.
    Introduction And Objectives: Angiogenesis is a complex event facilitated by angiogenic factors released from neoplastic and host immune cells. Among host immune cells, mast cells (MCs) may have greater significance in tumor progression through angiogenesis. The objectives of the study were to evaluate and correlate mast cell density (MCD) and microvessel density (MVD) in normal gingival tissue, leukoplakia with and without dysplasia and oral squamous cell carcinoma (OSCC) cases. Read More

    Association between oral leukoplakia and risk of upper gastrointestinal cancer death: A follow-up study of the Linxian General Population Trial.
    Thorac Cancer 2017 Nov 20;8(6):642-648. Epub 2017 Sep 20.
    Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
    Background: This study was conducted to explore the association between oral leukoplakia (OL) and the risk of upper gastrointestinal cancer death in the Linxian General Population Trial Cohort.

    Methods: A prospective cohort study of the Linxian General Population Trial Cohort was performed. Participants with OL were treated as an exposed group, and the remainder was selected as a control group. Read More

    Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial.
    Int J Pharm Investig 2017 Apr-Jun;7(2):88-93
    Department of Oral Medicine and Radiology, KLE Vishwanath Katti Institute of Dental Sciences, Belagavi, Karnataka, India.
    Aim: The aim of the study is to assess the efficacy of Calendula officinalis gel as cost-effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia.

    Materials And Methods: The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensed C. Read More

    Impacts of survivin and caspase-3 on apoptosis and angiogenesis in oral cancer.
    Oncol Lett 2017 Sep 20;14(3):3774-3779. Epub 2017 Jul 20.
    Department of Oral Medicine, Beijing Stomatological Hospital of China, Capital Medical University, Beijing 100050, P.R. China.
    The present study aimed to investigate the impact of survivin and caspase-3 on apoptosis and angiogenesis in oral cancer. A total of 16 oral leukoplakia cases accompanied by low-moderate epithelial dysplasia, 12 cases of oral leukoplakia accompanied by severe epithelial dysplasia, 17 cases of high-moderate differentiated oral squamous cell carcinoma and 10 cases of normal oral mucosa were selected. Immunohistochemistry was used to detect the expression levels of survivin, caspase-3, and caspase inhibitor factor VIII in lesions from each group. Read More

    Chemoprevention of oral cancer in leukoplakia patients: A systematic review and meta-analysis.
    J Pak Med Assoc 2017 Sep;67(9):1415-1419
    Department of Pathology, Stomatological Hospital of Zhengzhou University.
    The systematic review and meta-analysis of published randomised controlled trials (RCTs) was conducted to review the effectiveness of current chemopreventive agents in the treatment of oral leukoplakia lesions (OPLs) and prevention of their progression to oral cancer. Material was identified through a retrospective literature search of the electronic PubMed database, Embase and Cochrane Library between 2008 and 2016.Eight RCTs were included for systematic review. Read More

    Malignant transformation of oral leukoplakia in a patient with dyskeratosis congenita.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Oct 12;124(4):e239-e242. Epub 2017 Aug 12.
    Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
    Dyskeratosis congenita (DC) is a rare, inherited, bone marrow failure syndrome caused by premature telomere shortening. The classic mucocutaneous triad of clinical features comprises reticulated skin pigmentation, nail dysplasia, and oral leukoplakia. Multiple somatic features, including bone marrow failure, pulmonary fibrosis, and liver disease, are also common. Read More

    Oral leukoplakia and oral cavity squamous cell carcinoma.
    Clin Dermatol 2017 Sep - Oct;35(5):461-467. Epub 2017 Jun 27.
    Department of Otolaryngology-Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, CA.
    Oral leukoplakia is defined as a white oral lesion not related to another disease process. These lesions are largely asymptomatic, and the clinical relevance of oral leukoplakia is primarily tied to its association with oral cavity squamous cell carcinoma. Timely workup and effective management of these lesions can reduce the risk of malignant transformation and promote early diagnosis of invasive tumors. Read More

    Evaluation of Genetic Polymorphisms in Glutathione S-Transferase Theta1, Glutathione S-Transferase Mu1, and Glutathione S-Transferase Mu3 in Oral Leukoplakia and Oral Squamous Cell Carcinoma with Deleterious Habits using Polymerase Chain Reaction.
    Int J Appl Basic Med Res 2017 Jul-Sep;7(3):181-185
    Dental Practioner, Dentoes Multispeciality Dental Clinic, Kotha Venkjipalem, India.
    Context: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. As per previous studies, most patients who develop oral cancer are elderly males who are heavy users of tobacco and alcohol; however, the incidence is increasing in younger individuals and in those who neither smoke nor drink. Many of the genes that code for the detoxification enzymes are polymorphic with abnormal activity profiles. Read More

    Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases.
    Mol Med Rep 2017 Nov 5;16(5):6780-6786. Epub 2017 Sep 5.
    Cytogenetics and Genomics Laboratory, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal.
    Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions are likely to progress to cancer would be vital to guide their future clinical management. Read More

    Malignant Transformation in Leukoplakia and Its Associated Factors in Southern Iran: A Hospital Based Experience.
    Iran J Public Health 2017 Aug;46(8):1110-1117
    Dept. of Pathology and Lab Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
    Background: We evaluated factors that affect malignant transformation of leukoplakia in a sample of the Iranian population.

    Methods: The records of patients with a clinical diagnosis of leukoplakia during a 20-year period from 1989-2009 referred to two of the largest referral centers in southern Iran were studied. Patients that developed malignant transformation were compared with patients that did not have malignant changes. Read More

    Treatment resistance in potentially malignant disorders-'Nature' or 'Nurture'…?
    J Oral Pathol Med 2017 Nov 18;46(10):902-910. Epub 2017 Sep 18.
    Newcastle University Medicine Malaysia, Iskandar Puteri, Malaysia.
    Background: Contemporary potentially malignant disorder management is based upon provisional histological diagnosis followed by interventional surgery to excise or ablate 'high-risk' mucosal lesions. Although the majority of patients achieve disease-free status post-treatment, others develop further or persistent disease unresponsive to intervention.

    Methods: A detailed, retrospective clinico-pathological review of treatment resistant potentially malignant lesions, from a 590 patient cohort treated by CO2 laser surgery and followed for a mean of 7. Read More

    Human papillomavirus infection in oral potentially malignant disorders and cancer.
    Arch Oral Biol 2017 Nov 26;83:334-339. Epub 2017 Aug 26.
    Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People's Republic of China. Electronic address:
    Human papillomavirus (HPV) infects keratinocytes in the mucosa or skin, and persistent infection with HPV may lead to premalignant lesions and invasive cancer, especially cervical cancer. It has also been hypothesized that HPV infection is an etiological factor of oral squamous cell carcinoma and oral precancerous disorders such as lichen planus, leukoplakia, and erythroplakia. A high percentage of HPV in oral lesions supports the possible viral contribution, but an association of HPV infection with these lesions remains to be established. Read More

    Importance of Early Detection of Potentially Malignant Lesions in the Prevention of Oral Cancer.
    Mater Sociomed 2017 Jun;29(2):129-133
    Maxillofacial surgery Clinical Center of Sarajevo, Bosnia and Hercegovina.
    Objective: The aim of this study was to assess the importance of early diagnosis of potentially malignant lesions in the prevention of oral cancer.

    Material And Methods: In order to achieve the set objectives, we selected our participant pool. Of the 340 patients who came to the initial examination at the Clinic for Oral Medicine and Periodontology, we selected 40 patients with potentially malignant oral lesions (PMOL) of both sexes and of different ages. Read More

    Factors affecting Clinical Outcomes after Treatment of Oral Leukoplakia with CO2 and Diode Laser.
    J Contemp Dent Pract 2017 Sep 1;18(9):775-780. Epub 2017 Sep 1.
    Division of Clinic in Oral Medicine, Department of Stomatology School of Dentistry, University of Sao Paulo, Av. Prof. Lineu Prestes 2227, Cidade Universitaria, Sao Paulo, SP 05508900, Brazil Phone: +551130917883, e-mail:
    Introduction: To analyze factors that may affect recurrence, development of new lesions, and malignant transformation in patients with oral leukoplakia (OL) following surgical treatment with lasers.

    Materials And Methods: A total of 40 patients were enrolled in this study, 17 females (mean age of 64.5 years; 33-88 years) and 23 males (mean age of 56. Read More

    Serum metabolomics in oral leukoplakia and oral squamous cell carcinoma.
    J Cancer Res Ther 2017 Jul-Sep;13(3):556-561
    Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.
    Context: Metabolomics is a core discipline of system biology focusing on the study of low molecular weight compounds in biological system. Analysis of human metabolome, which is composed of diverse group of metabolites, can aid in diagnosis and prognosis of oral squamous cell carcinoma (OSCC).

    Aim: The aim of the present study is to analyze and identify serum metabolites in oral leukoplakia and OSCC as a potential diagnostic biomarker and a predictor for malignant transformation of oral leukoplakia. Read More

    Novel Molecular Targets for Chemoprevention in Malignancies of the Head and Neck.
    Cancers (Basel) 2017 Aug 31;9(9). Epub 2017 Aug 31.
    Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA.
    Cancers of the head and neck region are among the leading causes of cancer-related mortalities worldwide. Oral leukoplakia and erythroplakia are identified as precursor lesions to malignancy. Patients cured of an initial primary head and neck cancer are also susceptible to developing second primary tumors due to cancerization of their mucosal field. Read More

    Pre-Cancerous Lesions in the Oral and Maxillofacial Region: A Literature Review with Special Focus on Etiopathogenesis.
    Iran J Pathol 2016 ;11(4):303-322
    Dental Research Center, Dept. of Oral Pathology, Dental Faculty, Hamadan University, Hamadan, Iran.
    Many types of cancers develop in the oral and maxillofacial region. Squamous cell carcinoma is the most common cancer and constitutes over 90 percent of these tumors. Malignant transformation is a genetic process, which later makes a phenotyping change at the cellular level. Read More

    Autophagy analysis in oral carcinogenesis.
    Pathol Res Pract 2017 Sep 5;213(9):1072-1077. Epub 2017 Aug 5.
    Department of Oral Pathology - Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil. Electronic address:
    Objective: The aim of this study was to evaluate the levels of autophagy in oral leukoplakia and squamous cell carcinoma and to correlate with clinical pathological features, as well as, the evolution of these lesions.

    Methodology: 7 Normal oral mucosa, 51 oral leukoplakias, and 120 oral squamous cell carcinomas (OSCC) were included in the study. Histological sections of the mucosa and leukoplakias were evaluated throughout their length, while the carcinomas were evaluated using Tissue Microarray. Read More

    Effect of Frequency and Duration of Tobacco Use on Oral Mucosal Lesions – A Cross-Sectional Study among Tobacco Users in Hyderabad, India
    Asian Pac J Cancer Prev 2017 08 27;18(8):2233-2238. Epub 2017 Aug 27.
    Purpose: Tobacco use is one of the most important risk factors for the development of oral mucosal lesions including oral pre-cancer and cancer. The type and location of the lesion varies with the type of tobacco used, the way it is used, and the frequency and duration of use. Hence, the present study aimed to determine the effect of frequency and duration of tobacco use on oral mucosal lesions among tobacco users in Hyderabad city. Read More

    Efficacy of oral brush biopsy in potentially malignant disorder management.
    J Oral Pathol Med 2017 Nov 5;46(10):896-901. Epub 2017 Sep 5.
    Oral & Maxillofacial Surgery, Oral Health Centre, School of Dentistry, University of Queensland, Brisbane, QLD, Australia.
    Background: Oral potentially malignant disorders (PMD) harbour unpredictable risk for squamous cell carcinoma development. Current management requires tissue biopsy for histopathology characterisation, dysplasia grading and targeted intervention to "high-risk" lesions, although evidence-based guidelines are limited and diagnoses subjective. This study investigated the use of adjunctive oral brush biopsy techniques during the management of PMD in a UK hospital population. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Type of surgical treatment and recurrence of oral leukoplakia: A retrospective clinical study.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e520-e526. Epub 2017 Sep 1.
    Medicine and Oral Surgery Department, Instituto Univesitário de Ciências da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal,
    Background: Oral leukoplakia (OL) is the most typical potentially malignant disorder of the oral mucosa. We aimed to evaluate the clinical outcome of oral leukoplakia treated with several types of lasers and with the use of quantic molecular resonance (QMR) lancet, in terms of recurrence rate.

    Material And Methods: Eighty-seven previously untreated OL (52 occurring in females and 35 in males, mean age of 59. Read More

    Diagnosis of Oral Hairy Leukoplakia: The Importance of EBV In Situ Hybridization.
    Int J Dent 2017 17;2017:3457479. Epub 2017 Jul 17.
    Special Care Dentistry Center, Division of Oral and Maxillofacial Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil.
    Oral hairy leukoplakia (OHL) is caused by the Epstein-Barr virus (EBV), which has been related to HIV infection. In situ hybridization (ISH) is the gold-standard diagnosis of OHL, but some authors believe in the possibility of performing the diagnosis based on clinical basis. The aim of this study is diagnose incipient lesions of OHL by EBV ISH of HIV-infected patients and the possible correlations with clinical characteristics of the patients. Read More

    Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers.
    Oral Oncol 2017 Sep 20;72:132-139. Epub 2017 Jul 20.
    Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, South Korea; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul, South Korea. Electronic address:
    Objective: Squamous cell carcinomas (SCC) are the most common malignancies in the oral mucosa; these carcinomas have been preceded by potentially malignant oral disorders (PMODs), mostly oral leukoplakia (OL). No specific biomarker has been widely accepted for predicting the risk of malignant transformation of PMODs. The aim of this study was to develop an accurate prediction model for the malignant transformation of OL using clinical variables and candidate biomarkers. Read More

    Impact of oral potentially malignant disorders on quality of life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Qld, Australia.
    Background: Oral potentially malignant disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the quality of life (QoL) of affected patients.

    Methods: Oral leukoplakia (OL), oral lichen planus (OLP) and oral submucous fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    The methylation status and expression of human telomerase reverse transcriptase is significantly high in oral carcinogenesis.
    APMIS 2017 Sep 2;125(9):797-807. Epub 2017 Aug 2.
    Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Kitakyushu, Japan.
    Telomerase activity is present in most cancers and is tightly regulated by the expression of human telomerase reverse transcriptase (hTERT). Hypermethylation in the promoter region of hTERT contributes to the regulation of hTERT expression. In this study, we investigated the methylation and expression of hTERT in oral squamous cell carcinoma (OSCC), oral leukoplakia, and normal oral mucosa. Read More

    The variant of pri-mir-26a-1 polymorphism is associated with decreased risk of betel quid-related oral premalignant lesions and oral squamous cell carcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Oct 8;124(4):378-389.e1. Epub 2017 Jun 8.
    Investigator, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Professor, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:
    Objectives: This case-control study evaluated the association of the single nucleotide polymorphism rs7372209 (T>C) in pri-mir-26a-1 with the risk and progression of betel quid (BQ)-related oral premalignant lesions (OPLs) and oral squamous cell carcinoma (OSCC).

    Study Design: In total, 597 BQ chewers were recruited: 196 healthy controls, 241 patients with OPLs, and 160 patients with OSCC. Genotypes were determined using the TaqMan real-time assay. Read More

    Cytological study of DNA content and nuclear morphometric analysis for aid in the diagnosis of high-grade dysplasia within oral leukoplakia.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 18;124(3):280-285. Epub 2017 Jul 18.
    Department of Oral Mucosal Diseases, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:
    Objective: To quantitatively examine the DNA content and nuclear morphometric status of oral leukoplakia (OL) and investigate its association with the degree of dysplasia in a cytologic study.

    Study Design: Oral cytobrush biopsy was carried out to obtain exfoliative epithelial cells from lesions before scalpel biopsy at the same location in a blinded series of 70 patients with OL. Analysis of nuclear morphometry and DNA content status using image cytometry was performed with oral smears stained with the Feulgen-thionin method. Read More

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