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Medicina (Kaunas) 2022 Jun 15;58(6). Epub 2022 Jun 15.

Department of Morpho-Functional Sciences II, Faculty of Medicine, University of Medicine and Pharmacy, "Grigore T. Popa", 700115 Iasi, Romania.

Dentists play a very important part in the early identification of oral cancer lesions. This aspect of dental practice depends on the knowledge acquired during the faculty years. The aim of this study was to assess dental students' and residents' levels of awareness in terms of oral cancer. Read More

Cancers (Basel) 2022 May 30;14(11). Epub 2022 May 30.

Health Research Institute Foundation of Santiago (FIDIS), (ORALRES Group) Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, University of Santiago de Compostela (MedOralRes Group), 15782 Santiago de Compostela, Spain.

Background: Oral leukoplakia (OL) is considered one of the most common potentially malignant oral disorders (OPMD), with a verified increased risk of developing oral cancer. The identification of the dysplasia grade (low-high) is the only consolidated factor used to evaluate this risk. The objective of this study was to verify the role of the fractal dimension (FD) in assessing this dysplasia. Read More

Sci Rep 2022 Jun 7;12(1):9391. Epub 2022 Jun 7.

Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, People's Republic of China.

Photodynamic therapy (PDT) is an alternative microinvasive approach with satisfying results in the treatment of oral leukoplakia (OL). PDT combined with laser irradiation shows promise, safety and efficacy in treating OL. The efficacy of waterlase (YSGG) combined with PDT was studied by brush and tissue biopsy. Read More

Phytomedicine 2022 Aug 22;103:154195. Epub 2022 May 22.

Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China. Electronic address:

Background: Oral leukoplakia (OLK), an uncharacterized pathological condition that occurs as a white patch in the oral mucosa, is the most common precancerous condition. Scutellaria baicalensis Georgi (SBG) is a medicinal plant with a wide range of pharmacological effects. Increased evidence shows that SBG has potential therapeutic effects on OLK. Read More

Oral Oncol 2022 Jul 30;130:105941. Epub 2022 May 30.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:

Background: There is few longitudinal study on oral potentially malignant disorder (OPMDs) focusing on oral leukoplakia (OLK) with clinical endpoints to investigate the role of autofluorescence imaging (AFI) for surveilling the malignant transformation.

Methods: Based on our previous prospective diagnostic study enrolled 517 OPMD patients, 184 OLK patients were retrieved to further investigate the role of AFI using VELscope in predicting malignant transformation. During a median follow-up period of 44 months, 19 (10. Read More

Oral Oncol 2022 Jul 30;130:105944. Epub 2022 May 30.

Department of Oral and Maxillofacial Pathology, Tamil Nadu Government Dental College and Hospital, Chennai 600 003, India; Affiliated to theThe Tamil Nadu Dr. MGR Medical University ,No. 69, Anna Salai, Guindy, Chennai 600 032. Electronic address:

Diagnostics (Basel) 2022 May 20;12(5). Epub 2022 May 20.

Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, WHO Collaborating Centre for Oral Cancer, London SE1 9RT, UK.

Objective: To systematically review the clinicopathological features of oral warty keratoma based on published literature.

Materials And Methods: PubMed and Scopus databases were searched for reports of oral warty dyskeratoma. Of the 52 identified articles, only 25 articles (43 cases) satisfied the selection criteria (case report/series in the English language reporting clinicopathologically diagnosed oral warty dyskeratoma/oral focal acantholytic keratosis/oral isolated dyskeratosis follicularis in humans). Read More

Cancers (Basel) 2022 May 13;14(10). Epub 2022 May 13.

Department of Oral and Maxillofacial Reconstructive Surgery, Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan.

This study aimed to clarify the advantages and disadvantages of conventional visual inspection (CVI), endoscopic white light imaging (WLI), and narrow-band imaging (NBI) and to examine the diagnostic accuracy of intraepithelial papillary capillary loops (IPCL) for the detection of oral squamous cell carcinoma (OSCC). This cross-sectional study included 60 participants with oral mucosal diseases suspected of having oral potentially malignant disorders (OPMDs) or OSCC. The patients underwent CVI, WLI, NBI, and incisional biopsy. Read More

Biomolecules 2022 Apr 19;12(5). Epub 2022 Apr 19.

Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, The WHO Collaborating Centre for Oral Cancer, London SE1 9RT, UK.

Our aim was to evaluate the expression of biomarkers, CD44v6, CD147, EGFR, p53, p63, p73, p16, and podoplanin in oral leukoplakias (OL) and to assess their potential for prediction of malignant transformation (MT). We analyzed the expression of CD44v6, CD147, EGFR, p53, p63, p73, p16, and podoplanin by immunohistochemistry in 52 OL, comprised of 41 low-grade (LG) dysplasia and 11 high-grade (HG) cases. Twelve healthy normal tissues (NT) were also included. Read More

Photodiagnosis Photodyn Ther 2022 May 22:102910. Epub 2022 May 22.

Emergency Department, State Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu 610041, Sichuan Province, China. Electronic address:

Non-homogeneous oral verrucous/granular leukoplakia is a potentially malignant disorder with a higher malignant transformation rate than homogeneous leukoplakia. Surgical resection is commonly performed since the disease is often malignant and refractory. However, surgical intervention is painful and heavily impairs the patients' quality of life. Read More

J Oral Pathol Med 2022 May 20. Epub 2022 May 20.

Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela, Santiago, Spain.

Background: Proliferative verrucous leukoplakia is considered an uncommon oral potentially malignant disorder with a high malignant transformation rate. The objective of this paper was to define its cancer incidence and related risk factors.

Methods: A retrospective audit of 34 patients diagnosed with proliferative verrucous leukoplakia from a university-based unit, during the period from 1995 to 2019 was performed. Read More

Klin Lab Diagn 2022 Apr;67(4):219-226

Federal budgetary institution of science "Nizhny Novgorod research Institute of epidemiology and microbiology named after academician I.N. Blokhina Rospotrebnadzor".

Purpose of the study improving the diagnosis of precancerous diseases and cancer of the oral mucosa using fluorescent immunocytochemical studies by direct immunofluorescence. A clinical laboratory examination of 111 patients was carried out: 46 patients with squamous cell carcinoma of the oral mucosa, 35 people with precancerous lesions (17 leukoplakia, 18 - oral lichen planus) and 30 healthy people. All patients underwent a traditional cytological examination and an additional immunocytochemical examination by direct immunofluorescence, the expression levels of tumor markers P53, P16 and Ki67 were determined. Read More

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):31-37. Epub 2022 Mar 31.

Department of Oral and Maxillofacial Pathology and Microbiology, Santosh Dental College and Hospital, Santosh University, Ghaziabad, Uttar Pradesh, India.

Background: Saliva contains a large array of metabolites, many of which can be informative for the detection of diseases. Gas chromatography-mass spectrometry (GC-MS) is a system that has long been used for metabolite profiling owing to its sensitivity, specificity, reproducibility and synchronized analysis; it has relatively broad coverage of compound classes including sugars, sugar alcohols, glycosides and lipophilic compounds.

Aim And Objectives: The present study was conducted to explore the use of GC-MS in assessing variation in salivary metabolites and to recognize the metabolites which can be used as disease diagnostic tools and metabolite markers for detection of oral squamous cell carcinoma. Read More

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):21-25. Epub 2022 Mar 31.

Bio-Nano Scientist, Oncocur India Pvt. Ltd, Pune, Maharashtra, India.

Introduction: Oral leukoplakia has an estimated prevalence of 2% of the oral cavity, one of the risk factors for oral cancers. The most commonly linked etiology being tobacco smoking causing reactive oxygen species (ROS) induced DNA damage. Curcumin, a polyphenol derivative from herbal remedy, possesses diverse properties ranging from centuries old documented anti-inflammatory properties to recently documented anticancer properties. Read More

Front Pharmacol 2022 20;13:825266. Epub 2022 Apr 20.

Computational Biology and Bioinformatics Lab, Institute of Life Sciences, Bhubaneswar, India.

Among oral diseases, oral cancer is a critical health issue due to its life-threatening potential. Globocan, in its 2020 report, estimated ∼0.37 million new cases of oral cancer, with the majority of them coming from the Asian continent. Read More

Arch Oral Biol 2022 Jul 27;139:105447. Epub 2022 Apr 27.

Beijing Stomatological Hospital, Capital Medical University, Tiantanxili No 4#, Dongcheng District, Beijing 100050, China. Electronic address:

Objective: To determine whether the breast cancer susceptibility gene 1 (BRCA1) regulates oxidative damage in oral cancer cells by interacting with nuclear factor erythroid 2-like 2 (NRF2).

Design: The BRCA1 gene was silenced in CAL-27 and DOK cells using specific shRNA, and NRF2 was activated with sulforaphane. The expression levels of BRCA1, NRF2 and its target genes were assessed by quantitative real-time polymerase chain reaction and western blotting. Read More

Med Clin North Am 2022 May 4;106(3):527-536. Epub 2022 Apr 4.

University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address:

Human immunodeficiency virus (HIV)-associated disease is known for its protean manifestations. However, many of the characteristic findings on physical examination are not associated with HIV infection per se but the numerous opportunistic infections (OIs) that are common in patients with advanced HIV disease. Common findings of acute HIV infection include fever, adenopathy, rash, and oral ulcers. Read More

J Oral Pathol Med 2022 Apr 30. Epub 2022 Apr 30.

Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: A major challenge in the management of patients with oral leukoplakia is the difficulty to identify patients at high risk of developing oral squamous cell carcinoma. Our knowledge about genomic alterations in oral leukoplakia, and in particular those that progress to oral squamous cell carcinoma, is scarce and there are no useful biomarkers that can predict the risk of malignant transformation.

Methods: Using a novel, custom-made tissue microarray including 28 high-risk oral leukoplakias and the corresponding oral squamous cell carcinomas from 14 cases that progressed to cancer, we assayed copy number alterations involving the oral squamous cell carcinoma driver genes CDKN2A, CCND1, EGFR, and MYC by fluorescence in situ hybridization. Read More

Clin Oral Investig 2022 Apr 26. Epub 2022 Apr 26.

Department of Applied Statistics, Operational Research and Quality, Universitat Politècnica de València, Valencia, Spain.

Objectives: Our main purpose and research question were to analyze and quantify whether there were significant differences in the time to develop cancer among patients with oral leukoplakia (OL), comparing the more susceptible cases to those with the least susceptibility to malignancy.

Materials And Methods: We followed 224 cases of OL after surgical or CO laser treatment for a mean time of 6.4 years. Read More

Oxf Med Case Reports 2022 Apr 19;2022(4):omac042. Epub 2022 Apr 19.

Public Interest Incorporated Foundation Japanese Foundation for Cancer Research, Department of Gynecologic Oncology, Cancer Institute Hospital, Tokyo, Japan.

We present a case of tongue cancer manifestation from oral leukoplakia after administration of pegylated liposomal doxorubicin (PLD). A 56-year-old woman was diagnosed with ovarian cancer. After preoperative chemotherapy with paclitaxel and carboplatin (TC), she underwent interval debulking surgery. Read More

Front Pediatr 2022 6;10:834268. Epub 2022 Apr 6.

The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education of China, Shanxi University, Taiyuan, China.

Background: Dyskeratosis congenita (DC) is a rare inheritable disorder characterized by bone marrow failure and mucocutaneous triad (reticular skin pigmentation, nail dystrophy, and oral leukoplakia). Dyskeratosis congenita 1 () is responsible for 4.6% of the DC with an X-linked inheritance pattern. Read More

J Dent Res 2022 Apr 22:220345221092751. Epub 2022 Apr 22.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei.

Areca nut chewing is one of the major risk factors for oral cancer, with large-magnitude risks reported in studies comparing betel quid chewers and never users, and it has been evaluated as a group 1 carcinogen by the International Agency for Research on Cancer. Data from a high-quality meta-analysis examining risk estimates are presented in summary form with additional information from more recent studies (pooled adjusted relative risk, 7.9; 95% CI, 7. Read More

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S133-S138. Epub 2022 Feb 28.

Department of Translational and Precision Medicine, Division of Allogeneic Transplantation, "Sapienza" University of Rome, Rome, Italy.

Fanconi anemia (FA) is a rare genetic disease involving an increased risk of developing acute myeloid leukemia and solid tumors, especially head-and-neck squamous cell carcinomas, for which the oral cavity is the most frequent site of occurrence. The patient presented in this study underwent allogeneic hematopoietic stem cell transplantation (HSCT) and developed nonhomogeneous oral leukoplakia after 7 years, which was promptly removed and diagnosed with high-grade epithelial dysplasia. Many risk conditions for oral squamous cell carcinoma were featured in the present case including FA, allogeneic HSCT, graft-versus-host disease, immunosuppressive therapy, female gender, nonsmoker, tongue location and nonhomogeneous type of leukoplakia. Read More

Metabolites 2022 Mar 26;12(4). Epub 2022 Mar 26.

Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland.

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in which the consumption of tobacco and alcohol is considered to be the main aetiological factor. Salivary metabolome profiling could identify novel biochemical pathways involved in the pathogenesis of various diseases. This systematic review was designed to answer the question "Are salivary metabolites reliable for the diagnosis of oral squamous cell carcinoma?". Read More

Am Fam Physician 2022 04;105(4):369-376

Medical University of South Carolina College of Dental Medicine, Charleston, SC, USA.

Familiarity with common oral conditions allows clinicians to observe and treat patients in the primary care setting or refer to a dentist, oral surgeon, otolaryngologist, or other specialist. Recurrent aphthous stomatitis (canker sores) is the most common ulcerative condition of the oral cavity. Recurrent herpes simplex labialis and stomatitis also commonly cause oral ulcers. Read More

Ann Transl Med 2022 Mar;10(5):244

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.

Background: Although we have previously demonstrated that phospholipid complex loaded nanoparticles (PLC-NPs) encapsulating salvianolic acid B (SAB) can enhance anticancer activity in head and neck cancer and precancerous cells , the chemopreventive efficacy of SAB-PLC-NPs (nano-SAB) remains unclear. Here, we aimed to investigate the efficacy of nano-SAB against experimental oral carcinogenesis.

Methods: Oral tongue carcinogenesis was induced in C57BL/6 mice through the administration of 4-nitroquinoline-N-oxide (4NQO, 100 µg/mL) in drinking water for 22 weeks. Read More

J Maxillofac Oral Surg 2022 Mar 1;21(1):219-226. Epub 2020 Jul 1.

Department of Conservative and Endodontics, Awadh Dental College and Hospital, Jamshedpur, India.

Aim: To analyze and compare digital dermatoglyphic patterns in patients with oral leukoplakia and oral submucous fibrosis and their role as noninvasive diagnostic tool.

Materials And Methods: Two hundred patients were segregated into four groups of 50 patients each with oral leukoplakia, oral submucous fibrosis, and patients with habits but no lesions were included. They were compared with 50 subjects without habits and without lesions. Read More

J Dent Res 2022 Mar 31:220345221085192. Epub 2022 Mar 31.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P. R. China.

Some oral squamous cell carcinomas (OSCCs) originate from preexisting oral potentially malignant disorders (OPMDs). Oral leukoplakia (OLK) is the most common and typical OPMD in the clinic, so treatment for it is essential to reduce OSCC incidence. Local chemotherapy is an option other than surgery considering the superficial site of OLK. Read More

Int J Dent 2022 22;2022:5430309. Epub 2022 Mar 22.

Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.

Although oral lichen planus (OLP) and oral leukoplakia (LPL) have different pathogenetic profiles, both may involve chronic inflammation. The aim of this observational study was to evaluate the inflammatory cell profiles of OLP and LPL. The inflammatory cell infiltrates in patients with OLP and LPL were analyzed for the presence of Langerhans cells (LCs; CD1a), T cells (CD3), and B cells (CD20), as well as for the proliferation marker Ki-67. Read More

J Pathol 2022 Mar 31. Epub 2022 Mar 31.

National Institute of Biomedical Genomics, Kalyani, India.

A thickened, white patch - leukoplakia - in the oral cavity is usually benign, but sometimes (in ~9% of individuals) it progresses to malignant tumour. Because the genomic basis of this progression is poorly understood, we undertook this study and collected samples of four tissues - leukoplakia, tumour, adjacent normal, and blood - from each of 28 patients suffering from gingivobuccal oral cancer. We performed multiomics analysis of the 112 collected tissues (four tissues per patient from 28 patients) and integrated information on progressive changes in the mutational and transcriptional profiles of each patient to create this genomic narrative. Read More