5,136 results match your criteria Leukoplakia Oral


Bibliometric analysis of the top-cited articles on oral erythroplakia and leukoplakia.

Authors:
Xi Yang Wei Liu

J Oral Pathol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

We read with interest the recent article (jop12683) by Foy et al. [1] entitled "Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia". We congratulate the authors on conducting the first bibliometric analysis on oral erythroplakia and leukoplakia (OEL). Read More

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http://dx.doi.org/10.1111/jop.12863DOI Listing

HIV Status Does Not Worsen Oral Health Outcomes.

J Clin Periodontol 2019 Apr 21. Epub 2019 Apr 21.

Department of Oral Biology, School of Dental Medicine, University of Pittsburgh.

Last January 31 , Journal of Clinical Periodontology just made available the report titled "A Retrospective Analysis of Dental Implant Survival in HIV Patients", which concluded that "implants placed in HIV-positive patients had similar survival rates as HIV-negative patients." These data support our hypothesis that infection by HIV does not lead to worse oral health outcomes, including worse periodontitis. We looked 6,092 individuals and selected all HIV-positive subjects (N=73) and matched them by age, sex, ethnicity, and smoking habits with 261 HIV-negative control subjects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13116
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http://dx.doi.org/10.1111/jcpe.13116DOI Listing
April 2019
1 Read

Development and Validation of Nomogram for Prediction of Malignant Transformation in Oral Leukoplakia: A Large-Scale Cohort Study.

J Oral Pathol Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Objectives: Oral leukoplakia (OL) is the well-known disorder of oral mucosa, which has potential to be malignant and can lead to squamous cell carcinoma (OSCC). In the following study, we developed a comprehensive nomogram for predicting the malignant progression of OL, based on analysis of clinicopathological variables.

Materials And Methods: A retrospective analysis of patients diagnosed with OL was performed between 1998 and 2017 at the Peking University School and Hospital of Stomatology. Read More

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http://dx.doi.org/10.1111/jop.12862DOI Listing
April 2019
1 Read

Inter-observer Variability in the Diagnosis of Proliferative Verrucous Leukoplakia: Clinical Implications for Oral and Maxillofacial Surgeon Understanding: A Collaborative Pilot Study.

Head Neck Pathol 2019 Apr 10. Epub 2019 Apr 10.

Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, CA, USA.

The use of diverse terminology may lead to inconsistent diagnosis and subsequent mistreatment of lesions within the proliferative verrucous leukoplakia (PVL) spectrum. The objectives of this study were: (a) to measure inter-observer variability between a variety of pathologists diagnosing PVL lesions; and (b) to evaluate the impact of diverse terminologies on understanding, interpretation, and subsequent treatment planning by oral and maxillofacial surgeons (OMFS). Six oral pathologists (OP) and six head and neck pathologists (HNP) reviewed 40 digitally scanned slides of PVL-type lesions. Read More

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http://dx.doi.org/10.1007/s12105-019-01035-zDOI Listing
April 2019
1 Read

Hairy Tongue: Differential Diagnosis by Use of Widefield Optical Fluorescence.

Braz Dent J 2019 Mar-Apr;30(2):191-196. Epub 2019 Apr 4.

Núcleo de Pesquisa em Química Biológica (NQBio), UFSJ - Universidade Federal de São João Del Rei, Divinópolis, MG, Brasil.

Hairy tongue is a benign pathology, characterized clinically by hyperkeratinized plaques on the dorsal surface of the tongue, hairlike, whose coloration ranges from unpigment, whitish, yellowish, green, brown to black. Diagnosis is clinical, and, in cases of whitish plaques, it may be difficult to differentiate between oral hairy leukoplakia, potentially malignant leukoplakia or squamous cell carcinoma. Thus, widefield optical fluorescence complementary examination may allow a better visualization of the local hairlike pattern of hyperkeratinization, typical of the hairy tongue, facilitating the diagnosis. Read More

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http://dx.doi.org/10.1590/0103-6440201902270DOI Listing
April 2019
1 Read

Insight into verruciform xanthoma with oral submucous fibrosis: Case report and review of literature.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):43-48

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Dilsukhnagar, Hyderabad, Telangana, India.

Verruciform xanthoma (VX) is a rare benign mucocutaneous verrucopapillary lesion, which mainly involves masticatory mucosa and gingiva. Clinically, it presents as a solitary, sessile or pedunculated, white- or yellow-white-colored growth with a pebbled surface, hence often misdiagnosed as papilloma. The hallmark of histological diagnosis is the presence of foam cells or xanthoma cells confined to the connective tissue papillae. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_210_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421923PMC
February 2019
5 Reads

"Expression of p16 in oral leukoplakia and oral squamous cell carcinoma and correlation of its expression with individual atypical features".

J Oral Biol Craniofac Res 2019 Apr-Jun;9(2):156-160. Epub 2019 Mar 11.

Deptt. of Oral Pathology & Microbiology, Career Post Graduate Institute of Dental Science & Hospital, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1016/j.jobcr.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434494PMC

Study of oral potentially malignant disorders related to various risk factors amongst the patients attending hospitals in Bhopal, India.

Med Pharm Rep 2019 Jan 15;92(1):66-71. Epub 2019 Jan 15.

Department of Oral Medicine and Radiology, College of Dental Sciences and Hospital, Amargadh, District - BhavnagarGujarat, India.

Background And Aims: Oral potentially malignant disorders constitute one of the major oral health problems in India. Few studies have been undertaken on potentially malignant disorders in central India, specifically in Bhopal. Hence the present study was conducted to assess the oral potentially malignant disorders in the patients attending hospitals of Bhopal, India. Read More

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http://dx.doi.org/10.15386/cjmed-906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448500PMC
January 2019

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

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http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

Molecular alterations of mitochondrial D-loop in oral leukoplakia.

J Cell Biochem 2019 Apr 4. Epub 2019 Apr 4.

Department of Oral Pathology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Background: Over the years, numerous studies proposed a crucial role of mutations of nuclear DNA in the carcinogenesis process. Of late, many researchers suppose that alterations of mitochondrial DNA should not be excepted from this analysis. Mutational analysis of mitochondrial DNA displayed that mitochondrial D-loop is assessed as a hotspot for molecular alterations in various types of malignant tumors encompassing oral squamous cell carcinoma. Read More

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http://dx.doi.org/10.1002/jcb.28668DOI Listing
April 2019
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MAGE-A expression in oral and laryngeal leukoplakia predicts malignant transformation.

Mod Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Leukoplakia is a potential precursor of oral as well as laryngeal squamous cell carcinoma. Risk assessment of malignant transformation based on the grade of dysplasia of leukoplakia often does not lead to reliable results. However, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, and leukoplakia express single or multiple members of the melanoma-associated antigens A (MAGE-A) family, while MAGE-A are absent in healthy mucosal tissue. Read More

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http://dx.doi.org/10.1038/s41379-019-0253-5DOI Listing
April 2019
3 Reads

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.

Eur J Cancer Prev 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine, University of Tennessee Health Science Centre, Memphis, Tennessee, USA.

Around 300 000 patients are estimated to have oral cancer worldwide annually, and the incidence is higher in South Asian countries. In 2005, at the Congress of WHO, the term potentially malignant disorder (PMD)/lesion was suggested as a replacement for premalignant oral lesions and conditions. PMDs are those lesions of the oral mucosa that are at an increased risk of malignant transformation compared with the healthy mucosa. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000510DOI Listing

Differential diagnosis of leukoplakia versus lichen planus of the oral mucosa based on digital texture analysis in intraoral photography.

Adv Clin Exp Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Maxillofacial Surgery, Faculty of Military Medicine, Medical University of Lodz, Poland.

Background: A noninvasive, accurate and quick diagnosis is very important to general practitioners and specialists who care for the health of patients' oral cavity mucosa. The main enemies are precancerous lesions: leukoplakia and lichen planus (LP).

Objectives: The aim of this study was to attempt to formulate a differential diagnosis for leukoplakia vs LP in the oral mucosa based on digital texture analysis in intraoral macrophotography. Read More

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http://dx.doi.org/10.17219/acem/104524DOI Listing

Cytopathological tests for early detection of oral carcinogenesis.

Eur J Cancer Prev 2019 Mar 25. Epub 2019 Mar 25.

Department of Oral Pathology, Federal University of Rio Grande do Sul.

The carcinogenesis in the oral cavity occurs as a multistep process and is often preceded by potentially malignant lesions. The main risk factors for the development of oral cancer are smoking and alcohol intake. The current challenge is to identify patients at greatest risk for the development of oral cancer using noninvasive and effective methods. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000513DOI Listing

Micronuclei in Exfoliated Oral Epithelial Cells in Tobacco Users and Controls with Various Oral Lesions: A Study from Gujarat, India.

Indian J Otolaryngol Head Neck Surg 2019 Mar 2;71(1):109-114. Epub 2018 Feb 2.

Genomic Research Centre, Maharaja Sayajirao University, Sayajigunj, Aurobindo Ghosh Road, Nr Faculty of Science, Vadodara, 390002 Gujarat India.

To assess and compare cytogenic damage in the form of micronuclei in various oral lesions according to duration and frequency of tobacco use. The present cross sectional study was carried out from October 2015 to October 2016. We included total 420 cases with 60 cases in each of the following subgroups, no tobacco habit with no obvious oral lesion (control) and tobacco habit with no obvious oral lesion, oral sub mucous fibrosis, leukoplakia, melanoplakia, erythroplakia, oral squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s12070-018-1260-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401055PMC

Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions.

Int J Oncol 2019 May 19;54(5):1567-1578. Epub 2019 Mar 19.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.

Emerging evidence indicates that mesenchymal stem cells (MSCs) serve an indispensable role in the tumor microenvironment. However, whether MSCs participate in the development of oral carcinogenesis remains unclear. The present study isolated MSCs from clinical tissues and investigated the differences of MSCs derived from normal oral mucosa (N‑MSC), oral leukoplakia with dysplasia (LK‑MSC) and oral carcinoma (Ca‑MSC). Read More

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http://dx.doi.org/10.3892/ijo.2019.4756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438436PMC
May 2019
1 Read
3.025 Impact Factor

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature.

Curr Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. India.

Oral cancer (OC) is a serious and a growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in expected number of new cases in US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Read More

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http://www.eurekaselect.com/170833/article
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http://dx.doi.org/10.2174/1389450120666190319125734DOI Listing
March 2019
7 Reads

Expanded Expression of Toll-Like Receptor 2 in Proliferative Verrucous Leukoplakia.

Head Neck Pathol 2019 Mar 19. Epub 2019 Mar 19.

Dental College of Georgia, Augusta University, GC2250 1430 JW Gilbert Dr., Augusta, GA, 30912, USA.

Proliferative verrucous leukoplakia (PVL) is a premalignant condition of the oral mucosa with > 70% chance of progression to squamous cell carcinoma (SCC), while lacking the common risks and behavior seen in non-PVL oral squamous carcinogenesis. PVL follows a multi-stage slow, relentless and usually multifocal expansion of surface epithelial thickening that over time takes on a verrucous architecture, eventually leading to verrucous carcinoma and/or dysplasia followed by "conventional" SCC, a process that takes years and is notoriously difficult to manage. As mucosal surfaces and carcinomas arising at these sites, are colonized by microorganisms, host receptors for microbial products have received attention as potential contributors to carcinogenesis. Read More

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http://dx.doi.org/10.1007/s12105-019-01028-yDOI Listing
March 2019
4 Reads

Oral Epithelial Dysplasia and Premalignancy.

Authors:
Sook-Bin Woo

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Harvard School of Dental Medicine, Boston, MA, USA.

Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years. Importantly, traumatic/frictional keratoses are often mistaken clinically for leukoplakia and it is important for the pathologist to recognize and report them as such. The features of OED have been well-described and other architectural features will be discussed here, in particular verrucous and papillary architecture, bulky epithelial proliferation and epithelial atrophy. Read More

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http://dx.doi.org/10.1007/s12105-019-01020-6DOI Listing
March 2019
2 Reads

Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, , Green Tea and Coffee Properties.

Biomolecules 2019 03 17;9(3). Epub 2019 Mar 17.

Food Safety Research Center (Salt), Semnan University of Medical Sciences, Semnan 35198-99951, Iran.

Oral mucosal lesions have many etiologies, including viral or bacterial infections, local trauma or irritation, systemic disorders, and even excessive alcohol and tobacco consumption. Folk knowledge on medicinal plants and phytochemicals in the treatment of oral mucosal lesions has gained special attention among the scientific community. Thus, this review aims to provide a brief overview on the traditional knowledge of plants in the treatment of oral mucosal lesions. Read More

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http://dx.doi.org/10.3390/biom9030106DOI Listing

Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review.

Cureus 2018 Dec 31;10(12):e3802. Epub 2018 Dec 31.

Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, IND.

Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in India and most other developing countries. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Hence, these patients warrant regular screening by oral health care professionals and proper monitoring for any dysplastic changes. Read More

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http://dx.doi.org/10.7759/cureus.3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402749PMC
December 2018
1 Read

Assessment of salivary endothelin-1 in patients with leukoplakia, submucous fibrosis, oral cancer and healthy individuals - a comparative study.

J Stomatol Oral Maxillofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Faculty of Dental Sciences, Ramaiah University of Applied Sciences, India.

Background: Oral cancer is one of the highly prevalent cancers worldwide being. According to data of GLOBOCAN 2018, the estimated incidence, mortality and 5-year survival rates due to lip, oral cavity and salivary gland cancer in world is (2.0%), (0. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.024DOI Listing
March 2019
2 Reads

Evaluation of enzymatic and non-enzymatic antioxidant status and biomarkers of oxidative stress in saliva of patients with oral squamous cell carcinoma and oral leukoplakia: a pilot study.

Acta Odontol Scand 2019 Mar 11:1-11. Epub 2019 Mar 11.

a Chair of Periodontology and Clinical Pathology of the Oral Cavity , Jagiellonian University, Medical College , Krakow , Poland.

Objective: The study aimed to evaluate total antioxidant capacity as well as levels of various enzymatic and non-enzymatic antioxidants, and oxidative stress markers in saliva of patients with oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL).

Material And Methods: Twenty patients with OSCC, 20 patients with OL and 20 healthy subjects were enrolled into this prospective study. Total Antioxidant Capacity (TAC), activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) as well as levels of total glutathione (tGSH), reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, uric acid (UA), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were estimated in saliva using appropriate biochemical methods. Read More

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http://dx.doi.org/10.1080/00016357.2019.1578409DOI Listing
March 2019
1 Read

[Clinical significance of microtubule-associated protein 1 light chain 3 and mammalian target of rapamycin expression in oral leukoplakia in smokers and never-smokers].

Hua Xi Kou Qiang Yi Xue Za Zhi 2019 Feb;37(1):19-24

Stomatological Center, Xiangya Second Hospital of Central South University, Changsha 410011, China.

Objective: This study aimed to investigate the expression patterns and relationship of microtubule-associated protein 1 light chain 3 (LC3B) and mammalian target of rapamycin (mTOR) in oral leukoplakia (OLK) in smokers and never-smokers. This work also analyzed the relationship between smoking and the carcinogenic potential of OLK.

Methods: Immunohistochemistry was used to detect the expression of LC3B and mTOR in 120 patients with OLK. Read More

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http://dx.doi.org/10.7518/hxkq.2019.01.004DOI Listing
February 2019

Long-term cigarette smoking suppresses NLRP3 inflammasome activation in oral mucosal epithelium and attenuates host defense against Candida albicans in a rat model.

Biomed Pharmacother 2019 May 7;113:108597. Epub 2019 Mar 7.

Nanjing Stomatological Hospital & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, Jiangsu Province, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, Jiangsu Province, China. Electronic address:

Cigarette smoke (CS) exposure and Candida albicans (C. albicans) infection are epidemiological risk factors for oral diseases, such as oral leukoplakia (OLK). Smoking-induced inflammation and immune modulation are potentially important mechanisms in the development of diseases, although the biological mechanism of how CS exposure impacts host defenses has not been elucidated. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.058DOI Listing
May 2019
4 Reads
2.023 Impact Factor

Validity of narrow band imaging in the detection of oral and oropharyngeal malignant lesions: A systematic review and meta-analysis.

Head Neck 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology, Westmead Public Hospital, Sydney, New South Wales, Australia.

Background: This meta-analysis describes the validity of narrow band imaging (NBI) in the assessment of suspicious oral lesions.

Methods: Medline, EMBASE, and Scopus were searched for trial studies comparing NBI with conventional modalities in the oral cavity (OC) and oropharynx (OP) for the detection of dysplastic and malignant change.

Results: Seven studies were found, and generally supported the utility of NBI in different clinical settings, although there were exceptions. Read More

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http://dx.doi.org/10.1002/hed.25724DOI Listing
March 2019
2.641 Impact Factor

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study.

J Dent (Tehran) 2018 Nov;15(6):358-364

Senior Lecturer, Department of Oral Medicine & Radiology, G Pullareddy Dental College & Hospital, Kurnool, Andhra Pradesh, India.

Objectives: The aim was to evaluate and compare pretreatment serum C-reactive protein (CRP) levels in patients with oral premalignancies and malignancies with that in healthy controls.

Materials And Methods: The study sample consisted of 90 patients of both genders. The subjects were divided into three groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399459PMC
November 2018
5 Reads

Combined Testing of p16 Tumour-suppressor Protein and Human Papillomavirus in Patients With Oral Leukoplakia and Oral Squamous Cell Carcinoma.

Anticancer Res 2019 Mar;39(3):1293-1300

Department of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Background: Oral leukoplakia (OL) is a potentially malignant oral mucosal disorder. A casual association between OL, oral squamous cell carcinoma (OSCC) and human papillomavirus (HPV) infection has been suggested, but no conclusive evidence has been presented. p16, a tumour-suppressor protein, is used as a surrogate marker for HPV infection. Read More

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http://dx.doi.org/10.21873/anticanres.13241DOI Listing

Prevalence of oral mucosal lesions among smokeless tobacco usage: A cross-sectional study.

Indian J Cancer 2018 Oct-Dec;55(4):404-409

Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.

Background: Tobacco use is one of the most prevalent forms of habit and associated with development of potential malignant disorders. The aim of the present study was to investigate the prevalence and distribution of oral mucosal lesions (OMLs) among smokeless tobacco users.

Materials And Methods: This is a hospital-based cross-sectional study. Read More

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http://dx.doi.org/10.4103/ijc.IJC_178_18DOI Listing
March 2019
7 Reads

Oxidative Stress and Oral Mucosal Diseases: An Overview.

In Vivo 2019 Mar-Apr;33(2):289-296

Section of Dentistry, Interdisciplinary Department of Medicine, School of Medicine, Aldo Moro University of Bari, Bari, Italy

Background: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. Read More

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http://dx.doi.org/10.21873/invivo.11474DOI Listing
November 2018
1 Read

Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions.

J Biomed Opt 2019 Feb;24(2):1-10

Rice University, Department of Bioengineering, Houston, Texas, United States.

Oral premalignant lesions (OPLs), such as leukoplakia, are at risk of malignant transformation to oral cancer. Clinicians can elect to biopsy OPLs and assess them for dysplasia, a marker of increased risk. However, it is challenging to decide which OPLs need a biopsy and to select a biopsy site. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.025003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383051PMC
February 2019
1 Read

[DNA cytometry of exfoliated cells in the diagnosis of oral potential malignant disorders].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):16-20

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the diagnostic efficiency of oral mucosa disease, especially oral squamous cell carcinoma (OSCC) and oral potential malignant disorders (OPMDs) by DNA cytometry compared with histopathological diagnosis, so as to find a convenient, simple and low-invasive method for screening and follow-up.

Methods: 203 subjects with OSCC, OPMDs and other oral mucosa disease without dysplasia according to the inclusion criteria and exclusion criteria were recruited from Peking University School and Hospital of Stomatology. The mean age was (52. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.004DOI Listing
February 2019
2 Reads

Oral White Lesions: An Updated Clinical Diagnostic Decision Tree.

Dent J (Basel) 2019 Feb 7;7(1). Epub 2019 Feb 7.

Oral Medicine Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, 1983969411 Tehran, Iran.

Diagnosis of oral white lesions might be quite challenging. This review article aimed to introduce a decision tree for oral white lesions according to their clinical features. General search engines and specialized databases including PubMed, PubMed Central, EBSCO, Science Direct, Scopus, Embase, and authenticated textbooks were used to find relevant topics by means of MeSH keywords such as "mouth disease", "oral keratosis", "oral leukokeratosis", and "oral leukoplakia". Read More

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http://dx.doi.org/10.3390/dj7010015DOI Listing
February 2019

The microbiome and oral cancer: More questions than answers.

Oral Oncol 2019 Feb 17;89:30-33. Epub 2018 Dec 17.

Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland. Electronic address:

Recent advances in DNA sequencing technology have facilitated rapid advances in the analysis of the human microbiome and its role in human disease. Several studies have now shown that OSCC and some oral premalignant conditions are associated with alterations in the oral microbiome. These studies raise questions regarding the role of the oral microbiome in the progression of oral malignancies and whether microbiome change is a significant risk factor in the development of oral cancer. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.003DOI Listing
February 2019
1 Read

Primary Clinical Evaluation of Photodynamic Therapy With Oral Leukoplakia in Chinese Patients.

Front Physiol 2018 22;9:1911. Epub 2019 Jan 22.

Department of Oral Medicine, Peking University School of Stomatology, Beijing, China.

Photodynamic therapy (PDT) has demonstrated promising results in the treatment of oral leukoplakia. This study evaluated the clinical efficacy and side effects of PDT in the treatment of Chinese patients with oral leukoplakia. Twenty-nine patients with oral leukoplakia were enrolled in this study, including patients with both homogenous and non-homogenous lesions and various dysplastic tissues. Read More

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http://dx.doi.org/10.3389/fphys.2018.01911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350274PMC
January 2019
4 Reads

Oral submucous fibrosis: A clinicopathological study of 674 cases in China.

J Oral Pathol Med 2019 Feb 4. Epub 2019 Feb 4.

Department of oral pathology, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China.

Background: Oral submucous fibrosis (OSF) has been reported frequently in India and other countries in South Asia. There are few reports on the clinicopathological features of OSF in China, where OSF is an epidemic. This study analyses the clinicopathological features of OSF in Hunan Province, China. Read More

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http://dx.doi.org/10.1111/jop.12836DOI Listing
February 2019
1 Read

Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma.

J Oral Pathol Med 2019 Feb 3. Epub 2019 Feb 3.

Department of Research, Saveetha Institute of Medical and Technical Sciences, Chennai, India.

Background: Metabolomics is the study of metabolome which describes the full repertoire of small molecules, and the analysis of salivary metabolomics may help in identifying tumor-specific biomarkers for early diagnosis and prediction of tumor progression. The aim of the study was to evaluate the clinical utility of salivary metabolites in oral leukoplakia and oral squamous cell carcinoma.

Methods: Salivary metabolomic profile of patients diagnosed with oral leukoplakia (n = 21) and oral squamous cell carcinoma (n = 22) was compared with apparently normal controls (n = 18) using Q-TOF-liquid chromatography-mass spectrometry. Read More

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http://dx.doi.org/10.1111/jop.12835DOI Listing
February 2019
1 Read

Stress activated p38 MAPK regulates cell cycle via AP-1 factors in areca extract exposed human lung epithelial cells.

Cytotechnology 2019 Apr 2;71(2):507-520. Epub 2019 Feb 2.

Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi, Bengaluru, Karnataka, 560 056, India.

Areca nut chewing habits are associated with several oral manifestations like leukoplakia, submucous fibrosis and oral squamous cell carcinoma. Although numerous evidence on areca toxicity is known but the mechanistic pathway of disease causation is to be studied. Aqueous areca nut extract treated A549 cells showed reduced cell viability by 48 h with IC value of 0. Read More

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http://dx.doi.org/10.1007/s10616-019-00297-3DOI Listing
April 2019
3 Reads
1.752 Impact Factor

S100 Proteins as Biomarkers in Risk Estimations for Malignant Transformation in Oral Lesions.

Methods Mol Biol 2019 ;1929:763-771

Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.

Oncologic relevant members of S100 proteins are described as promising biomarkers in molecular pathology for risk estimation in oral neoplasia exhibiting different stages of malignancy: gingiva as healthy tissue, irritation fibroma as benign, leukoplakia as precancerous, and oral squamous cell carcinoma as malignant entity. Gene expression levels of S100A4 (metastasin), S100A7 (psoriasin), S100A8 (calgranulin A), and S100A9 (calgranulin B) were analyzed using quantitative RT-PCR. In addition, immunohistochemistry-based microscopy was used to examine cellular localization and distribution of these biomarkers in tissue sections. Read More

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http://link.springer.com/10.1007/978-1-4939-9030-6_48
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-9030-6_48DOI Listing
January 2019
7 Reads

[Research progress of dyskeratosis congenita].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):130-134

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Dyskeratosis congenita (DC) is a rare disease and a genetic heterogeneity of bone marrow failure, characterized by muco-cutaneous triad of mucosal leukoplakia, abnormal skin pigmentation, nails dystrophy and often involving multiple organs or systems. The inheritance patterns of DC include X-linked recessive, autosomal dominant and recessive patterns. However, the inheritance patterns in 30%-40% of DC patients remained unknown. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.02.010DOI Listing
February 2019
2 Reads

[Clinicopathological Study of the Resected Oral Leukoplakia Cases].

Gan To Kagaku Ryoho 2018 Dec;45(13):1970-1972

Dept. of Oral and Maxillofacial Surgery, National Hospital Organization Hamada Medical Center.

Oral leukoplakia is the most common premalignant or potentially malignant lesion in the oral mucosa. This retrospective study examined 67 lesions from 62 patients with clinical diagnoses of oral leukoplakia who underwent surgical excision in our department from 2015 to 2017. The patients comprised 22 men and 40 women. Read More

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December 2018

Clinical photography: Attitudes among dental students in two dental institutions.

Eur J Dent Educ 2019 Jan 25. Epub 2019 Jan 25.

Department of Community Dentistry, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

Introduction: Clinical photography is an important tool in teaching, clinical practice and academia especially for mucosal pathologies. Our aim was to examine differences in attitude towards clinical photography for mucosal pathologies among students.

Methods: Questionnaires about clinical photography were completed by students in dental teaching hospitals in Birmingham (UK) and in Israel (ISR). Read More

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http://dx.doi.org/10.1111/eje.12424DOI Listing
January 2019
2 Reads
1.448 Impact Factor

Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity.

Ann Otol Rhinol Laryngol 2019 May 24;128(5):472-479. Epub 2019 Jan 24.

1 Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives: Describe the demographics and clinical manifestations of laryngeal cryptococcosis. Develop a simple approach to the diagnostic workup and treatment of localized laryngeal cryptococcal infection.

Methods: A new case of laryngeal cryptococcosis encountered at our institution is presented and placed in context of the literature surrounding prior reported cases. Read More

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http://dx.doi.org/10.1177/0003489419826131DOI Listing
May 2019
1 Read

Is Periodontitis Independently Associated with Potentially Malignant Disorders of the Oral Cavity?

Asian Pac J Cancer Prev 2019 Jan 25;20(10):283-287. Epub 2019 Jan 25.

Department of Public Health Dentistry, Sharavathi Dental College and Hospital, Shimoga, India. Email:

Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Read More

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http://journal.waocp.org/article_80973.html
Publisher Site
http://dx.doi.org/10.31557/APJCP.2019.20.1.283DOI Listing
January 2019
6 Reads

Nail dystrophy and oral leukoplakia in a 3-year-old girl.

Pediatr Dermatol 2019 Jan;36(1):149-151

Department of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain.

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http://dx.doi.org/10.1111/pde.13690DOI Listing
January 2019

Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus.

Int J Cancer 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology, New York University School of Medicine, New York, NY.

Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. Read More

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http://doi.wiley.com/10.1002/ijc.32152
Publisher Site
http://dx.doi.org/10.1002/ijc.32152DOI Listing
January 2019
11 Reads

Lichenoid Characteristics in Premalignant Verrucous Lesions and Verrucous Carcinoma of the Oral Cavity.

Head Neck Pathol 2019 Jan 22. Epub 2019 Jan 22.

University of Florida, Gainesville, USA.

Verrucous hyperkeratosis (VH), verrucous carcinoma (VC) and the relentless, truly pre-malignant variant proliferative verrucous leukoplakia often exhibit lichenoid histologic features that may create a diagnostic dilemma for pathologists. This study aims to evaluate and categorize the frequency and the histopathologic patterns of lichenoid features seen in these lesions. Following IRB approval, cases of VH and VC from 1994 to 2014 were retrieved from the archives of UF Oral Pathology Biopsy Service. Read More

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http://dx.doi.org/10.1007/s12105-019-01006-4DOI Listing
January 2019
2 Reads

Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.

Authors:
Susan Müller

Head Neck Pathol 2019 Mar 22;13(1):16-24. Epub 2019 Jan 22.

Atlanta Oral Pathology, Emory Decatur Hospital, Emory University School of Medicine, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Read More

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http://dx.doi.org/10.1007/s12105-018-0986-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405791PMC
March 2019
2 Reads

Knowledge of Oral Cancer among the Fourth and Fifth Year Dental Students.

Acta Stomatol Croat 2018 Dec;52(4):340-347

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Background: The literature data show insufficient knowledge and awareness about oral cancer among dental and medical students.

Objective: To assess the knowledge of graduating dental students regarding oral cancer and to assess their awareness regarding the prevention and early detection of oral cancer. Also student's smoking status was examined aimed to investigate their attitude towards smoking as a risk factor for development of oral cancer and to assess the prevalence of smoking among dental students. Read More

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http://www.ascro.hr/fileadmin/user_upload/2018/Number_2018-4
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http://dx.doi.org/10.15644/asc52/4/8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336452PMC
December 2018
5 Reads

Efficacy of Fluorescence Technology vs Conventional Oral Examination for the Early Detection of Oral Pre-Malignant Lesions. A Clinical Comparative Study.

Endocr Metab Immune Disord Drug Targets 2019 Jan 18. Epub 2019 Jan 18.

Ionian Department, University of Bari "Aldo Moro", Bari. Italy.

Background And Objective: Oral cancer is one of the most common malignancies that affect human beings across the world and early detection of oral cancer is believed to reduce the morbidity significantly. Fluorescence diagnosis is emerging as a promising method in the differentiation of cancerous lesions and thus helping in the determination of resolution for the surgical resection of affected area of malignancy very accurately. The aim of this study was to evaluate the usefulness of an autofluorescence hand held device (OralID) to detect oral premalignant lesions. Read More

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http://dx.doi.org/10.2174/1871530319666190119103255DOI Listing
January 2019
2 Reads