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Acta Clin Croat 2019 Dec;58(4):615-620

1Department of Oral Surgery, School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 2Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb University Hospital Centre, Zagreb, Croatia; 3student, School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 4PhD student, School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 5University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

The use of lasers for treatment of oral leukoplakia has gained a lot of interest in the past years, however, data on the use of Er:YAG laser are scarce. The aim of this study was to compare the efficacy of Er:YAG laser and 1% topical isotretinoin in the treatment of 27 oral leukoplakia patients. Er:YAG laser (LightWalker AT, Fotona, Slovenia) was used in 27 patients with 27 leukoplakia lesions. Read More

Photodiagnosis Photodyn Ther 2020 Jun 25:101888. Epub 2020 Jun 25.

Multidisciplinary Department of Medical and Dental Specialties, University of Campania- "Luigi Vanvitelli", 80138 Naples, Italy.

Background: Photodynamic therapy (PDT) is a minimally invasive method for the treatment of oral leukoplakia (OL) through the activation of a photosensitizer, after exposure to a specific wavelength light source.

Methods: To investigate the effectiveness of toluidine blue as topical photosensitizer. Eleven patients participated in this study; fifteen oral leukoplakia lesions were treated, in several sessions, with 2. Read More

Arkh Patol 2020 ;82(3):55-60

Peoples' Friendship University of Russia, Moscow, Russia.

The article is devoted to the modern perspectives of the etiology, pathogenesis, diagnosis and prognostic factors in theoral squamous cell carcinoma. In the new edition of the WHO Classification of Head and Neck Tumors of 2017, the concept of potentially malignant diseases is introduced, which include erythroplakia, leukoplakia, oral submucous fibrosis, dyskeratosiscongenita, smokeless tobacco keratosis, palatallesions associated with reverse smoking, chronic candidiasis, lichen planus, discoid lupus erythematosus, syphilitic glossitis and actinic keratosis (liponly). A binary system for assessing oral epithelial dysplasia assessing is proposed. Read More

Arkh Patol 2020 ;82(3):13-17

Peoples' Friendship University of Russia(RUDN university), Moscow, Russia.

Aim Of Study: To study of neoplastic transformation of the epithelial cells of the oral mucosa with verrucous hyperortokeratosis, verrucous carcinoma and oral squamous cell carcinoma (OSCC).

Materials And Methods: Oral mucous membrane biopsies of 33 patients with clinical diagnosis of proliferative verrucous leukoplakia were investigated. Histologically in 19 cases (57. Read More

Int J Oral Maxillofac Surg 2020 Jun 22. Epub 2020 Jun 22.

Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. Electronic address:

Proliferative verrucous leukoplakia (PVL) is a rare and refractory form of oral mucosal leukoplakia of unknown origin, characterized by high rates of malignant transformation. Different diagnostic criteria, terminologies, and therapeutic approaches have been proposed since the first report in 1985. There remains no general agreement regarding the clinical and histological diagnosis, prevention, and correct management of this disease. Read More

Braz Oral Res 2020 5;34:e052. Epub 2020 Jun 5.

Central South University, Xiangya Hospital, Center of Stomatology, Changsha, Hunan, China.

The purpose of this study was to analyze the differential expression of DEC1 in oral normal mucosa (NM), oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Surgically excised specimens from patients with OLK (n = 47), OSCC (n = 30) and oral normal mucosa (n=11) were immunostained for DEC1. The expression of DEC1 protein was evaluated, and its association with the clinicopathological features was analyzed. Read More

Oral Dis 2020 Jun 22. Epub 2020 Jun 22.

Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden.

Objectives: Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC), and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world.

Patients And Methods: A total of 432 patients with OL from Sweden, Brazil and Romania was analysed. Read More

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Biomedical and Neuromotor Sciences, Functional MR Unit, IRCCS Istituto Delle Scienze Neurologiche di Bologna, University of Bologna, Bologna, Italy.

Background: A non-invasive sampling procedure for the early detection of Oral Squamous Cell Carcinoma (OSCC) based on DNA methylation analysis of a panel of 13 genes was applied in 4 different OSCC risk-group of patients. Aim of the study is to evaluate the between-group differences and the variables related to the methylation profile of each group.

Methods: Oral brushing samples were collected from 54 healthy subjects, 31 Oral Leukoplakia (OL) patients, 18 Oral Lichen Planus (OLP) patients and 26 patients previously treated for OSCC. Read More

Ophthalmic Genet 2020 Jun 16:1-5. Epub 2020 Jun 16.

Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami , Miami, FL, USA.

Coats plus syndrome (CP) is a rare condition characterized by bilateral exudative retinal telangiectasias with associated systemic disorders primarily affecting the brain, bone and gastrointestinal tract due to a mutation in the gene. mutations are also known to cause dyskeratosis congenita (DC), which is an inherited bone marrow failure syndrome characterized by skin pigmentation abnormalities, nail dystrophy, and oral leukoplakia. This is the first reported case of a patient diagnosed with both CP and DC caused by compound heterozygous gene mutations. Read More

Oral Oncol 2020 Jun 12;109:104850. Epub 2020 Jun 12.

Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.

Oral leukoplakia (OL) is a white lesion with high potential of recurrence and malignant transformation. The variable clinical and histopathological features of OL may potentially impact both treatment and prognosis. Current literature shows that post treatment rates of recurrence and malignant transformation vary widely. Read More

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):183. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India.

Background: Pathology involving the oral epithelium may alter the level of salivary concentration of LDH. Thus its estimation can be used as a non invasive screening tool for the early detection of OPMDs and also to predict its malignant transformation especially in high risk population.

Aims And Objectives: To evaluate the salivary and serum levels of lactate dehydrogenase (LDH) in patients having of oral submucous fibrosis (OSMF) and leukoplakia and compare it with healthy individuals. Read More

PLoS One 2020 3;15(6):e0233058. Epub 2020 Jun 3.

Human Genetics Unit, Indian Statistical Institute, Kolkata, India.

It is hypothesized that same driver gene mutations should be present in both oral leukoplakia and cancer tissues. So, we attempted to find out mutations at one of the driver genes, CASP8, in cancer and adjacent leukoplakia tissues. Patients (n = 27), affected by both of cancer and adjacent leukoplakia, were recruited for the study. Read More

Cell Biosci 2020 24;10:68. Epub 2020 May 24.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fluids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2020 Jun;55(6):421-424

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Oral erythroplakia is an rare oral disorder with relatively high potential of becoming malignant. It has a lower prevalence but a higher malignant transformation rate than oral leukoplakia. The etiology and pathogenesis of the disease is so far not clear, but several studies have pointed to tobacco chewing, tobacco smoking, and betel quid chewing with or without tobacco and alcohol usage as etiologic factors. Read More

J Natl Cancer Inst 2020 Jun 1. Epub 2020 Jun 1.

Klinik für Mund-, Kiefer- und Gesichtschirurgie, Marienhospital Stuttgart, Stuttgart, Germany.

Head Neck 2020 May 21. Epub 2020 May 21.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

Background: Cigarette smoking is a major risk factor for head and neck squamous cell carcinoma. Still, the effect of cigarette smoke on the molecular level is unclear. The aim of the present study was to investigate the early effects of cigarette smoke on carcinogenesis of head and neck squamous cell carcinoma. Read More

Clin Oral Investig 2020 May 20. Epub 2020 May 20.

Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

Objective: The main objective of the study was to identify the determinants that contribute to the malignant transformation of oral leukoplakia in a group of patients managed in secondary care. A secondary objective was to compare two dysplasia grading systems to determine their utility in assessing the prognosis.

Material And Methods: The cohort consisted of 93 patients diagnosed during the period 2009-2013. Read More

J Contemp Dent Pract 2020 Mar 1;21(3):304-309. Epub 2020 Mar 1.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangaluru, Karnataka, India.

Aim: The aim of this study was to evaluate the use of tobacco and its association with oral precancers and cancers.

Materials And Methods: Medical records of 1,007 individuals were assessed for the patterns of tobacco abuse and the presence of tobacco-related oral mucosal alterations.

Results: This study comprised 1,007 individuals (M:F: 95. Read More

Diagn Cytopathol 2020 May 20. Epub 2020 May 20.

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Oral submucous fibrosis (OSF) is an insidious chronic oral and oropharyngeal potentially malignant disorder. Our previously studies reported that DNA image cytometry (ICM) using brushing added in the diagnosis of high-grade dysplasia and staging of oral leukoplakia (OLK). This preliminary study aimed to investigate the abnormal rate of DNA content in 30 cases of OSF including three cases of OSF concomitant OLK and evaluate their the diagnostic and clinical implications with special emphasis on the OSF concomitant OLK. Read More

Clin Pract Cases Emerg Med 2020 May 27;4(2):234-240. Epub 2020 Apr 27.

Reynold's Memorial Hospital, Department of Emergency Medicine, Glen Dale, West Virginia.

Introduction: Emergency physicians are trained to treat a variety of ailments in the emergency department (ED), some of which are emergent, while others are not. A common complaint seen in the ED is a sore throat. While most sore throats are easily diagnosed and treated, less common causes are often not considered in the differential diagnoses. Read More

iScience 2020 May 4;23(5):101131. Epub 2020 May 4.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NTNU, Trondheim 7030, Norway; Department of Computer and Information Science, Norwegian University of Science and Technology, NTNU, Trondheim 7491, Norway; Bioinformatics Core Facility-BioCore, Norwegian University of Science and Technology, NTNU, Trondheim 7491, Norway; K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NTNU, Trondheim 7491, Norway.

Understanding microbial communities' roles in human health and disease requires methods that accurately characterize the microbial composition and their activity and effects within human biological samples. We present sMETASeq (small RNA Metagenomics by Sequencing), a novel method that uses sequencing of small RNAs to jointly measure host small RNA expression and create metagenomic profiles and detect small bacterial RNAs. We evaluated the performance of sMETASeq on a mock bacterial community and demonstrated its use on different human samples, including colon cancer, oral leukoplakia, cervix cancer, and a panel of human biofluids. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jul 14;130(1):e5-e9. Epub 2020 May 14.

Associate Professor, Faculty of Dentistry, King Abdul-Aziz University, Jeddah, Saudi Arabia. Electronic address:

Introduction: Contact stomatitis (CS) is an inflammatory reaction of the oral mucosa induced by contact with an irritant, such as menthol and cinnamon compounds. We are reporting 2 cases of CS related to the use of kolanut, a caffeine-containing nut of evergreen trees.

Case Description: Case 1 was a 22-year-old man with history of chewing kolanut for the past 10 years; he presented with a grayish-white, velvety, leukoplakia-like plaque with ill-defined borders in the mandibular anterior facial vestibule and extending to the lower labial mucosa. Read More

Head Neck 2020 May 16. Epub 2020 May 16.

Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aim: The COVID-19 pandemic has resulted in society experiencing unprecedented challenges for health care practitioners and facilities serving at the frontlines of this pandemic. With regard to oral cancer, there is a complete absence of literature regarding the long-term impact of pandemics on patients with oral potentially malignant disorders (OPMDs). The objective of this article is to put forth an institutional multidisciplinary approach for the evaluation and management of OPMDs. Read More

Arch Oral Biol 2020 Jul 4;115:104738. Epub 2020 May 4.

Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, Brazil; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, Brazil. Electronic address:

Objective: To evaluate the prevalence of HPV DNA detection in fresh tissue from oral leukoplakia by Linear Array assay, and its correlation with p16 immunoexpression in the northwest region of the São Paulo state, Brazil.

Patients And Methods: Fifty patients diagnosed with oral leukoplakia were included in the study. Sociodemographic, clinicopathologic and lifestyle data, fresh tissue and formalin fixed paraffin embedded (FFPE) tissue samples were collected. Read More

Cureus 2020 Apr 8;12(4):e7585. Epub 2020 Apr 8.

Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, ITA.

Conventional surgery for potentially malignant lesions of the lip may result in unaesthetic sequela. Diode laser allows a careful surgical excision of lip lesions without intraoperative bleeding and stitches, promoting a fast mucosal healing, thereby leading to a complete restitutio ad integrum of lip mucosa without aesthetic complications. Read More

Cureus 2020 Apr 5;12(4):e7551. Epub 2020 Apr 5.

Oral and Maxillofacial Surgery, Thai Moogambigai Dental College and Hospital, Chennai, IND.

Introduction Overexpression of survivin, an anti-apoptotic protein, has been associated with the progression of cancer, resistance to drugs, and a poor prognosis. The expression level of survivin indicates the progression of the disease, early recurrence, and a failure to respond to therapy. Our study was a retrospective analysis performed on archival specimens. Read More

Kurume Med J 2020 Jul 1;66(1):15-27. Epub 2020 May 1.

AL-FALAH School of Medical Sciences and Research Center, AL- Falah University.

Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (TXN2). They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. Read More

Int J Environ Res Public Health 2020 May 4;17(9). Epub 2020 May 4.

Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland.

Periodontal diseases are multiperspective problems resulting from numerous and diverse exposures that influence the process of initiation or progression of disease. The negative influence of tobacco smoking on oral health is well documented. The aim of the study was to analyze three SNPs in vitamin D receptor gene-rs7975232 (), rs2228570 () and rs1544410 ()-combined with oral health assessment-pH, gingival index, dry mouth, periodontitis, dry socket, redness of oral cavity mucosa, leukoplakia-in a group of cigarette smokers and in non-smokers. Read More

Pediatr Dermatol 2020 May 5. Epub 2020 May 5.

Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.

We report a case of atypical oral hairy leukoplakia (OHL) in a 9-year-old immunocompetent girl treated with fluticasone propionate nasal spray for allergic rhinitis. The OHL in childhood is uncommon and should be included in a differential diagnosis of white lesions in the oral mucosa. Read More

Oral Dis 2020 Apr 29. Epub 2020 Apr 29.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China.

Objectives: This study aimed to examine the association between hyperglycemia and the malignant transformation of oral leukoplakia (OLK).

Patients And Methods: This retrospective case-control study involved 133 patients with the malignant transformation of OLK into oral squamous cell carcinoma (case group) and 266 patients with untransformed OLK (control group). The clinical history and follow-up data included age, gender, lesion size and location, and fasting plasma glucose. Read More

J Appl Oral Sci 2020 27;28:e20190532. Epub 2020 Apr 27.

Departamento de Odontologia Conservadora, Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.

Oral leukoplakia (OL) is a white lesion of an indeterminate risk not related to any excluded (other) known diseases or disorders that carry no increased risk for cancer. Many biological markers have been used in an attempt to predict malignant transformation; however, no reliable markers have been established so far. Objective To evaluate cell proliferation and immortalization in OL, comparing non-dysplastic (Non-dys OL) and dysplastic OL (Dys OL). Read More

J Oral Microbiol 2020 21;12(1):1743066. Epub 2020 Mar 21.

Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.

has been found at high abundance on oral leukoplakia (OLK). The ability of clinical isolates to produce acetaldehyde (ACH) from ethanol has not been investigated. The objective of the current study was to determine the capacity of isolates recovered from OLK to generate ACH. Read More

Asian Pac J Cancer Prev 2020 Apr 1;21(4):1163-1166. Epub 2020 Apr 1.

Dental Assistant Surgeon, Hyderabad. India.

Background: Early detection of oral cancer is of critical importance because survival rates markedly improve when oral lesions are identified at an early stage. Aim of the present study is to investigate the expression of ABO (H) antigens in tissue specimens of oral cancer and potentially malignant disorders and to determine the role of ABO (H) antigens in tumour staging.

Materials And Methods: A prospective study was conducted on 60 cases of oral cancer and potentially malignant diseases. Read More

Asian Pac J Cancer Prev 2020 Apr 1;21(4):983-991. Epub 2020 Apr 1.

Departmen of Oral Medicine and Radiology, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.

Aim: To evaluate and compare salivary and serum levels of Alkaline Phosphates and Lactate Dehydrogenase in patients without the habit of tobacco, in patients with the habit of tobacco, in patients with benign oral lesions and in patients with oral premalignant lesions and oral malignant lesions.

Material And Methodology: This study was comprised of 500 subjects, Group I: 100 healthy individuals without the habit of tobacco usage formed the control group. Group II: 100 patients with the habit of tobacco/ smoking consumption without any oral lesion. Read More

Clin Ter 2020 May-Jun;171(3):e209-e215

Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, Italy.

Purpose: The purpose is to determine the sufficient extension of margins during laser ablation of oral leukoplakia and observe its short-term recurrence rate.

Materials And Methods: The study was designed as a randomized controlled clinical trial was conducted on 33 oral leukoplakia lesions diagnosed in 30 patients (16 Females and 14 Males) with an age range between 39 and 79 years. The lesions were divided into three groups; Group A: 11 lesions in 11 patients, in which the laser ablation was done for the entire lesion without extension of margins; Group B: 11 lesions in 8 patients, in which the laser ablation was done for the lesion adding at least 3mm extension of margins; and finally the Group Control: consists of 11 untreated lesions in 11 patients, in which only "wait and see" approach was done. Read More

J Family Med Prim Care 2020 Feb 28;9(2):1080-1085. Epub 2020 Feb 28.

Department of Public Health Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India.

Background: The habit of smoking and chewing tobacco is associated with various types of oral mucosal lesions and conditions, many of which pose a potential threat to cancer growth. The present study aims to evaluate the prevalence of potentially malignant lesions (PML) and oral cancer in North India and to identify the associated risk factors.

Materials And Methods: A cross-sectional study was carried out in the Department of Oral Medicine and Radiology Rama Dental College Hospital and research center Kanpur over a period of 5 years with1,10,625 patients. Read More

J Family Med Prim Care 2020 Feb 28;9(2):909-914. Epub 2020 Feb 28.

Super Specialty Cancer Institute and Hospital, Lucknow, Uttar Pradesh, India.

Background: Oral cancer is one of the most common forms of cancer in India. Majority of the patients are diagnosed at advanced stages, resulting in poor outcomes. Most of the oral cancers are preceded by visible lesions known as potentially malignant disorders (PMDs), which are amenable to early detection by screening. Read More

Contemp Clin Dent 2019 Apr-Jun;10(2):185-190

Department of Oral Pathology and Microbiology, Gitam Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India.

Introduction: Heat shock proteins are biomarkers regulating the degree of differention and aggressiveness in oral carcinogenesis. The study was carried out to evaluate the expression of HSP 70 in histological grades of epithelial dysplasia and oral squamous cell carcinoma using immunohistochemistry.

Methodology: A sample of 40, which included 10 (Normal), 15 (epithelial dysplasia) and 15 (oral squamous cell carcinoma) were selected. Read More

Oral Dis 2020 Apr 19. Epub 2020 Apr 19.

Australian Centre for Oral Oncology Research & Education, Perth, WA, Australia.

Objective: To systematically review retrospective studies examining prognostic potentials of candidate biomarkers to stratify malignant progression of oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL).

Materials And Methods: A systematic literature search of PubMed, EMBASE, Evidence-Based Medicine and Web of Science databases targeted literature published through 29 March 2018. Inter-rater agreement was ascertained during title, abstract and full-text reviews. Read More

Bone Marrow Transplant 2020 Apr 9. Epub 2020 Apr 9.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jun 2;129(6):600-611.e2. Epub 2020 Apr 2.

Faculdade de Medicina Dentária, Universidade de Lisboa, Lisbon, Portugal; Instituto de Implantologia, Lisbon, Portugal; LIBPhys-FCT UID/FIS/04559/2013, Lisbon, Portugal; Evidence Based Dentistry Research Center, Lisbon, Portugal. Electronic address:

Objective: The aim of this study was to perform a systematic review of prevalence studies to determine the rate of malignant transformation of oral leukoplakia and assess the influence of demographic factors (age, gender, and geographic region) on the overall transformation rate.

Study Design: A search was conducted for publications until July 2019 in 4 electronic databases and peer-reviewed journals. A manual search was performed on the bibliographies of the collected articles, and the authors were contacted for additional information. Read More

J Clin Med 2020 Mar 21;9(3). Epub 2020 Mar 21.

Jagiellonian University Medical College, Faculty of Medicine, Institute of Dentistry, Chair and Department of Periodontology and Clinical Oral Pathology, Montelupich 4, 31-155 Krakow, Poland.

Background: Oral squamous cell carcinoma (OSCC) is a life-threatening disease. It could be preceded by oral potentially malignant disorders (OPMDs). It was confirmed that chronic inflammation can promote carcinogenesis. Read More

Rev Prat 2019 Oct;69(8):856-860

Service de stomatologie et chirurgie maxillofaciale, groupe hospitalier Pitie-Salpêtrière- Charles Foix, département hospitalouniversitaire Fight Ageing and STress (DHU FAST) Paris, France ; Sorbonne Universités, UPMC Université de Paris 06, UMR 8256 B2A, Paris, France.

Potentially malignant disorders of the oral mucosa. The term "precancerous" is now abandoned in favor to « potentially malignant disorder » which provide a better view of the evolution a far from systematic. Of these disorders, leukoplakia is the most common while erythroplakia is rare. Read More

Transplant Proc 2020 Mar 25. Epub 2020 Mar 25.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Disorders of homeostasis and an increased incidence of infection in patients undergoing hemodialysis causes frequent appearance of pathologic changes in the oral mucosa. The organ transplant and subsequent pharmacologic immunosuppression may result in systemic disorders manifesting by pathologic oral lesions.

Methods: The study was conducted on 18 patients undergoing hemodialysis and 18 patients after renal transplant. Read More

Neoplasma 2020 May 18;67(3):707-713. Epub 2020 Mar 18.

Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, Shihezi University, Shihezi, China.

The clinical value of synuclein-γ (SNCG) in oral squamous cell carcinoma (OSCC) was evaluated by detecting the expression of SNCG in saliva and tissues and its correlation with clinicopathological parameters (age, gender, ethnicity, degree of differentiation, clinical stage, and lymph node metastasis). Salivary samples were collected from 79 patients with OSCC, 31 patients with oral premalignant lesions (OPMLs), such as oral lichen planus, oral leukoplakia, and erythema, and 80 controls, and levels of SNCG in salivary samples were determined by enzyme-linked immunosorbent assay (ELISA). Tissue expression in formalin-fixed tissue biopsies of 94 cases of OSCC and 30 adjacent normal tissues was analyzed by immunohistochemistry (IHC) using an antibody against SNCG. Read More

Sci Rep 2020 Mar 17;10(1):4869. Epub 2020 Mar 17.

Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA.

Cancer is a disease caused by a process that drives the transformation of normal cells into malignant cells. The late diagnosis of cancer has a negative impact on the health care system due to high treatment cost and decreased chances of favorable prognosis. Here, we aimed to identify orofacial conditions that can serve as potential risk markers for cancers by performing a phenome-wide scan (PheWAS). Read More

J Int Soc Prev Community Dent 2020 Jan-Feb;10(1):21-35. Epub 2020 Jan 24.

Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences, Dilsukhnagar, Hyderabad, Telangana, India.

Aims And Objectives: Human immunodeficiency virus (HIV)-related oral lesions are often an early finding, and they reflect the underlying immunosuppression, and tuberculosis (TB) coinfection can have further deteriorating effect. Hence, a cross-sectional study was conducted to evaluate clinical and oral presentations of patients coinfected with HIV-TB, correlating with various parameters such as the type of TB with CD4 cell count, the type of TB with oral manifestations, site of the lesion, oral manifestations with CD4 cell counts, age, and gender.

Materials And Methods: A cross-sectional study was conducted among selected 200 patients coinfected with HIV-TB, registered at Gandhi Medical College, Hyderabad, Telangana, India, and demographic data, CD4 count, diagnosis of TB, and clinical presentation of TB were correlated with site, age, gender, and the type of lesions in the oral cavity. Read More

Head Neck Pathol 2020 Mar 16. Epub 2020 Mar 16.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02215, USA.

Benign alveolar ridge keratosis (BARK), the intraoral counterpart of cutaneous lichen simplex chronicus, is a reactive hyperkeratosis caused by trauma or friction that presents as a poorly demarcated white papule or plaque on the keratinized mucosa of the retromolar pad or alveolar ridge mucosa (often edentulous). This is a clinical and histopathologic analysis of BARK including evaluation of p53 expression in selected cases. One hundred and sixty-seven cases of BARK were identified from 2016 to 2017 and 112 (67. Read More

Oral Dis 2020 Mar 6. Epub 2020 Mar 6.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Objectives: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.

Methods: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).

Results: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22. Read More

Cleve Clin J Med 2020 Mar;87(3):133-134

Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.