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Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland.

Background: The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous-like lesions with high risk of malignancy, and its biomarkers.

Methods: A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta-analysis was possible for human papillomavirus (HPV), aneuploidy, Ki-67, and p53. Read More

Rom J Morphol Embryol 2018 ;59(3):787-802

Department of Occlusology and Fixed Prosthetics, University of Medicine and Pharmacy of Craiova, Romania;

Aim: Occlusal trauma causes major modifications of the coverage periodontium, which in turn reflect on the dental unit. The aim of the present study is to evaluate some of the morphological modifications occurred in the marginal periodontium surrounding teeth affected by occlusal trauma.

Materials And Methods: Fragments of marginal periodontium coming from 51 patients with occlusal trauma were processed using classical histological techniques (formalin fixation and paraffin embedment) and stained with Hematoxylin-Eosin (HE), Masson's trichrome and anti-CD34 antibody immunostaining, in order to highlight the epithelial and connective tissue changes of gingival mucosa. Read More

Oral Oncol 2018 Dec 24;87:58-63. Epub 2018 Oct 24.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objectives: To elucidate the risk of malignant transformation to invasive oral cancer by subtypes of oral potentially malignant disorders (OPMD) and to examine the independent effects of risk factors, particularly alcohol drinking, by subtype based on a nationwide oral cancer screening program targeting at general population with habits of smoking and/or betel quids chewing.

Materials And Methods: The total of 8501 subjects diagnosed as different subtypes of OPMDs from the Taiwanese screening program between 2004 and 2009 were followed up over time to ascertain the occurrence of invasive oral cancer. The hazard ratios of malignant transformation were estimated by using Cox proportional hazards regression model. Read More

Urologia 2018 Dec 3:391560318810197. Epub 2018 Dec 3.

2 Pathology Unit, ASST-Rhodense, Milan, Italy.

Introduction:: Bladder mucosa is anatomically covered by urothelial epithelium. The replacement of the urothelium with stratified squamous cells is defined as squamous metaplasia which can be keratinizing or non-keratinizing. Clinically, it is also known as leukoplakia or keratinizing cystitis of the bladder. Read More

Laryngoscope 2018 Nov 28. Epub 2018 Nov 28.

Coastal Ear, Nose and Throat, Neptune, New Jersey; and the Jersey Shore University Medical Center, Neptune, New Jersey, U.S.A.

Objectives/hypothesis: Meticulous scrutiny of laryngeal lesions with laryngoscopes and microscopes often identify angiogenic activity, one of the hallmarks of neoplastic and preneoplastic lesions. The aim of this study was to determine if there is an association between laryngoscopic appearance and histopathology of laryngeal lesions based on operative biopsies.

Study Design: Retrospective case-control study. Read More

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

Transpl Infect Dis 2018 Nov 18:e13030. Epub 2018 Nov 18.

Department of Stomatology, Avenida Prefeito Lothário Meisser, 632, CEP: 80210-170, Federal University of Paraná, Curitiba, PR, Brazil.

Background: Fanconi anemia (FA) is a rare genetic disease usually characterized by bone marrow failure and congenital malformations. The risk of development of malignancies in the oral cavity of FA patients, such as squamous cell carcinoma (SCC), increases significantly after a hematopoietic stem cells transplant (HSCT), and may also be linked with the presence of human papillomavirus (HPV) infections in the oral cavity. We investigated the prevalence and the HPV genotypes in oral mucosa of Brazilian FA patients. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

Lasers Med Sci 2018 Nov 15. Epub 2018 Nov 15.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.

A series of studies are dedicated to research the clinical outcomes of oral leukoplakia (OLK) treated with carbon dioxide laser (CO laser); however, the results vary from studies especially related to recurrence and malignant transformation. Hence, we performed this meta-analysis to precisely evaluate the malignant transformation of OLK dealt with CO laser and investigate the association between its malignant transformation and kinds of related risk factors, such as gender, clinical classification, long duration of leukoplakia, and degree of epithelial dysplasia and lesion regions. We performed a systematic search of the Cochrane Library, EMBASE, Pubmed, Web of Science, and SCOPUS. Read More

J Int Soc Prev Community Dent 2018 Sep-Oct;8(5):396-401. Epub 2018 Oct 8.

Department of Public Health Dentistry, Sibar Institute of Dental Sciences and Research, Guntur, Andhra Pradesh, India.

Objective/aim: The aim of this study is to measure the association between oral mucosal lesions (OMLs) and habit of tobacco and alcohol in the population of Guntur city, Andhra Pradesh, South India.

Material And Method: A cross-sectional study was conducted on 300 participants in Guntur city with the habit of tobacco and alcohol consumption in various forms who were selected by stratified cluster random sampling technique. Guntur city was divided into four zones, that is, North, East, South, and West; and two administrative wards were randomly selected from each zone as clusters. Read More

Laryngoscope 2018 Nov 8. Epub 2018 Nov 8.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.

Objectives: To evaluate the feasibility of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) for vocal fold leukoplakia.

Study Design: Ex vivo and in vivo.

Methods: 5-ALA was applied topically as a 20% solution to ex vivo canine vocal folds. Read More

Photodiagnosis Photodyn Ther 2018 Oct 31. Epub 2018 Oct 31.

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai, 200072, PR China. Electronic address:

Objective: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral leukoplakia (OLK).

Methods: This systematic review aimed to address the following focused question: "Is photodynamic therapy effective in the management of oral leukoplakia?'' PubMed/Medline, EMBASE, ISI Web of Knowledge, OVID, CNKI, and WANFANG DATA were searched up to and including June 2018 using different combinations of the following keywords: photodynamic therapy, leukoplakia, oral dysplasia, oral precancers, and oral premalignant lesions.

Results: Sixteen studies were included in the present study. Read More

Acta Odontol Latinoam 2018 Aug;31(2):77-81

Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Anatomía Patológica, Argentina.

Tumor hypoxia is an important indicator of cancer prognosis. Among the different genes that are upregulated by hypoxia is carbonic anhydrase IX, which combines carbon dioxide and water to form bicarbonate and hydrogen. Although expression of this enzyme is very low in normal tissues, carbonic anhydrase IX is overexpressed in several types of cancer. Read More

Head Neck Pathol 2018 Oct 29. Epub 2018 Oct 29.

College of Dentistry, University of Florida, Gainesville, FL, USA.

Chronic ulcerative stomatitis (CUS) is a poorly understood disease with clinical and histologic overlap with lichen planus (LP). Unlike classic LP, direct immunofluorescence (DIF) studies in cases of CUS exhibit a granular pattern of IgG in nuclei of basal and parabasal cells. This study assesses the demographic, clinical, histologic, and DIF features of CUS. Read More

Pathol Oncol Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Jilin University, No. 218 Ziqiang Street, Changchun, 130041, China.

To study the expression of programmed death-ligand 1 (PD-L1), and its effects on CD8 tumor infiltrating lymphocytes (TILs) and tumor associated macrophages (TAMs) in human laryngeal squamous cell carcinoma. Sixty-nine patients with laryngeal carcinoma and 10 with vocal cord leukoplakia received tumor resection at Neck Surgery Department in the Second Affiliation Hospital of Jilin University (Changchun, Jilin) from Jan. 2010 to Dec. Read More

Dent Mater 2018 Dec 22;34(12):1756-1768. Epub 2018 Oct 22.

University of Regensburg Medical Center, Department of Conservative Dentistry and Periodontology, 93042 Regensburg, Germany.

Objective: Information on patients with real or claimed adverse reactions towards dental materials in large patient cohorts is rare. Therefore, the aim of the present study was to investigate patients reporting on complaints and symptoms to dental materials over a 16-year period.

Methods: Five hundred patients were characterized by one single dental team regarding age and sex distribution, subjective complaints and objective intraoral symptoms, and allergy status relevant to dental materials. Read More

Stomatologiia (Mosk) 2018 ;97(5):23-26

I.M. Sechenov First State Medical University, Moscow, Russia.

Research objective was assessment of a possibility of primary diagnosis of viruses Epstein-Burr, a cytomegalovirus, a virus of herpes of the 6th type in oral liquid and also influences of herpes infection on development and the clinical course of precancer diseases of the oral mucosa and the red border of lips (RBL). Profound clinic-immunological examination is conducted to 60 patients: the first group are have made 20 patients with an erosive and ulcer form of the lichen planus, the second - 20 people with an erosive form of a leukoplakia, a third - 20 people without diseases of the oral mucosa. As a result of work detection herpes infection is revealed high (90%). Read More

Environ Health Prev Med 2018 Oct 20;23(1):50. Epub 2018 Oct 20.

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Infection and inflammation account for approximately 25% of cancer-causing factors. Inflammation-related cancers are characterized by mutagenic DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. Our previous studies demonstrated the formation of 8-oxodG and 8-nitroguanine in the tissues of cancer and precancerous lesions due to infection (e. Read More

Photomed Laser Surg 2018 Oct 19. Epub 2018 Oct 19.

Oral Medicine Section, Department of Surgical Sciences, CIR-Dental School, University of Turin , Turin, Italy .

Objective: The purpose of this prospective analysis was to evaluate the efficacy of erbium-substituted yttrium aluminum garnet (Er:YAG) laser compared with that of conventional surgery, regarding the long-term outcome of nondysplastic oral leukoplakias (OL).

Background: To date, this comparison has never been performed.

Methods: Patients were randomly allocated to two different groups: some underwent surgical excision with traditional scalpel (Group TrSc) and others underwent an ablative session with Er:YAG laser (Group Las), with these modalities: 1. Read More

Cureus 2018 Aug 6;10(8):e3111. Epub 2018 Aug 6.

Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, JPN.

Objective: Fluorescence visualization devices are screening devices that can be used to examine lesions of the oral mucosa non-invasively. We observed oral squamous cell carcinoma (OSCC) and leukoplakia using the IllumiScan(Shofu, Kyoto, Japan) fluorescence visualization device and examined its usefulness and characteristics.

Methods: We investigated 31 OSCC and nine leukoplakia in patients who were examined using the IllumiScan and treated in our department from January 2017 to February 2018. Read More

Isr Med Assoc J 2018 Oct;20(10):623-626

Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Zerifin, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Leukoplakia of the vocal cords may represent a pre-cancerous lesion of the larynx. The management of cases of recurrent leukoplakia with pathologically proven dysplasia is still controversial.

Objectives: To present a series of patients with recurrent vocal cord leukoplakia and to examine their malignant transformation rate in relation to the clinical characteristics, risk factors, and histological findings. Read More

Sensors (Basel) 2018 Oct 10;18(10). Epub 2018 Oct 10.

SIB Labs, Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.

Many oral diseases, such as oral leukoplakia and erythroplakia, which have a high potential for malignant transformations, cause abnormal structural changes in the oral mucosa. These changes are clinically assessed by visual inspection and palpation despite their poor accuracy and subjective nature. We hypothesized that non-invasive bioimpedance spectroscopy (BIS) might be a viable option to improve the diagnostics of potentially malignant lesions. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(17):1335-11338

Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital,Capital Medical University, Beijing,100730,China.

To discuss the correlation of benign vocal cord lesions with occult vocal cord sulcus and the treatment of benign vocal cord lesions with occult vocal cord sulcus, through the analysis of surgical data, preoperative voice evaluation data and postoperative follow-up data of patients.:The data from 377 patients of benign vocal cord lesions with concealed vocal cord sulcus admitted to Beijing Tongren Hospital from 2005 to 2016 were reviewed. The follow-up time was more than half a year after surgery. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(16):1260-1264

Department of Otolaryngology Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, 200031,China.

To explore the association between the morphological classification and prognosis of conservative treatment for vocal fold leukoplakia. Patients with different types of vocal fold leukoplakia received conservative treatment first. Those who had failed response to conservative treatment or recurred received carbon dioxide laser resection. Read More

Indian J Med Res 2018 Jul;148(1):35-40

WHO Collaborating Centre for Oral Cancer; King's College London, London, UK.

Smokeless tobacco (SLT) use has many oral effects including oral cancer, leukoplakia and erythroplakia, oral submucous fibrosis (if mixed with areca nut), loss of periodontal support (recession) and staining of teeth and composite restorations. This review was aimed to provide information to identify oral lesions that occur due to the use of smokeless tobacco so that effective interventions can be undertaken to reduce morbidity and mortality from the use of SLT. Read More

Laryngoscope 2018 Sep 19. Epub 2018 Sep 19.

Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: The purpose of this study was to introduce a new narrow band imaging (NBI) endoscopic classification for the diagnosis of vocal cord leukoplakia.

Study Design: Case series.

Methods: From January 2010 to February 2018, a total of 120 cases of vocal cord leukoplakia were enrolled in this study. Read More

Clin Oral Investig 2018 Sep 19. Epub 2018 Sep 19.

Study Group on Head and Neck Cancer, São João del-Rei, Brazil.

Objective: The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4, and CD8 in premalignant lesions (OPML) that were transformed into oral squamous cell carcinoma OSCC (OPML-OSCC), in OSCC and also in premalignant lesions that were not transformed into OSCC (OPML-NOSSC).

Materials And Methods: Retrospective analyses were performed in order to verify the demographic characteristics of the patients. CD4, CD8, and PD1 IMH studies were carried out on OPML and OSCC samples from 11 patients with OPML-OSCC and OPML, together with samples from 14 patients with OPML-NOSCC. Read More

Mol Cancer Res 2018 Sep 17. Epub 2018 Sep 17.

Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology-Head and Neck Surgery, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Head and neck squamous cell carcinomas (HNSCC) develop in fields of genetically altered cells. These fields are often dysplastic and a subset can be recognized as (erythro)leukoplakia, but most are macroscopically invisible. There is a lack of adequate treatment options to eradicate these fields, whereas they underlie the development of primary tumors as well as part of the local relapses. Read More

Clin Otolaryngol 2019 Jan 9;44(1):39-46. Epub 2018 Oct 9.

Department of Otorhinolaryngology/Head and Neck surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Objectives: The primary goal was to study the diagnostic potential of narrow-band imaging (NBI), and the secondary goal was to evaluate the most common mistakes when using and interpreting NBI.

Design: Retrospective study.

Setting: University Medical Center Groningen, tertiary referral hospital, the Netherlands. Read More

Am J Cancer Res 2018 1;8(8):1403-1413. Epub 2018 Aug 1.

Stomatological Hospital, Southern Medical University Guangzhou 510260, China.

Oral squamous cell carcinoma (OSCC) remains to be a global health problem. However, the underlying molecular mechanisms regulating the oral leukoplakia (OLK) to OSCC remain poorly known. MicroRNAs (miRNAs) expression profiles of GSE33299 and GSE62809 were downloaded from gene expression omnibus (GEO) respectively. Read More

Oral Dis 2018 Sep 11. Epub 2018 Sep 11.

Department of Oral and Maxillofacial Surgery/Pathology, VU medical center/ACTA, Amsterdam, The Netherlands.

J Cancer Res Ther 2018 Jul-Sep;14(5):934-940

Department of Radiation Oncology, Silchar Medical College, Silchar, Assam, India.

Context: Head neck cancer (HNCA) in North-East India accounts for 54.48% cancers at all sites, one of the highest in the country. Increased serum lactate dehydrogenase (LDH) activity is considered as a marker of cellular necrosis while serum alkaline phosphatase (ALP) is recognized as an important marker of induction of tumor cell differentiation. Read More

J Cancer Res Ther 2018 Jul-Sep;14(5):921-925

Department of Oral and Maxillofacial Pathology and Microbiology, School of Dentistry, D. Y. Patil University, Nerul, Navi Mumbai, Maharashtra, India.

Background: Oral exfoliative cytology is a novel technique of using cells to detect dysplastic changes in the oral cavity in potentially malignant disorders and malignant oral lesions in resourced challenged areas. The aim of this study was to compare specimen adequacy and cellular clarity between oral rinse-based smears and conventional smears in normal controls, histologically confirmed and clinically diagnosed squamous cell carcinoma, and oral leukoplakia. For many years, oral rinse-based cytology has been used to detect candidal colonization in microbiology. Read More

Anticancer Res 2018 Sep;38(9):5211-5216

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan, R.O.C

Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs).

Materials And Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. Read More

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):177-181. Epub 2017 Apr 17.

Dept. of Peiodontology and Implantology, Hitkarini Dental College and Hospital, Boys Hostel, Room # 26, Hitkarini Hills, Dumna Road, Jabalpur, M.P., 482005, India.

Objectives: To assess the efficacy of Chemiluminescent light (Vizilite plus) in enhancing visualization and its ability to highlight Leukoplakia lesion.

Material And Methods: This was a cross-sectional study done on 40 study subjects. Subjects were inducted into the study irrespective of age and sex based on the specific inclusion and exclusion criteria. Read More

Br J Oral Maxillofac Surg 2018 Nov 3;56(9):780-785. Epub 2018 Sep 3.

Molecular and Clinical Cancer Medicine Department, University of Liverpool Cancer Research Centre.

Proliferative verrucous leukoplakia (PVL) is a potentially premalignant lesion that undergoes malignant transformation in over 40% of cases. Its clinical homogeneity suggests that a single or a small number of molecular pathogenic pathways may exist. Using the Cochrane protocol for systematic reviews, we have looked at the reported evidence of the molecular aetiology and pathogenesis of PVL and compared it with that of conventional oral epithelial dysplasia (OED). Read More

Exp Mol Pathol 2018 Dec 4;105(3):243-251. Epub 2018 Sep 4.

Vaidya laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400085, India. Electronic address:

Objective: We have previously reported the aberrant expression of vimentin in human oral premalignant lesions and a 4-Nitroquinoline 1-oxide (4NQO) model of rat lingual carcinogenesis. Hence, we wanted to understand whether the expression of vimentin in early stage contributes to the process of transformation.

Study Design: Vimentin was stably expressed in oral premalignant lesion derived cells (vimentin negative) and various transformation related phenotypic assays were performed. Read More

Transplant Proc 2018 Sep 11;50(7):2176-2178. Epub 2018 Apr 11.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: Patients subjected to long-term immunosuppressive therapy after organ and cells transplantation are more susceptible than healthy people to the development of the pathologic changes in the oral cavity, including precancerous lesions, oral cancers, lesions following viral infections (herpes simplex virus, Epstein-Barr virus, and cytomegalovirus), fungal infections mainly caused by Candida albicans, drug-induced gingival overgrowth, stomatitis, and tongue disorders.

Material And Methods: Clinical case material included 38 patients after kidney, liver, or blood-forming cells transplantation subjected to various immunosuppressive therapy schemes. The study comprised standard case taking and physical examination of the patient, including detailed intraoral and extraoral stomatological examinations. Read More

Int J Biochem Cell Biol 2018 Nov 30;104:34-42. Epub 2018 Aug 30.

Department of Stomatology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, 214023, China. Electronic address:

Oral leukoplakia (OL) is the most common premalignancy in the oral cavity. The objective of this study was to investigate the biological role of transglutaminase 3 (TGM3) in malignant transformation of OL and its clinical value for predicting oral squamous cell carcinoma (OSCC) risk in patients with OL. Immunohistochemistry was used to measure TGM3 expression in OL samples from 98 patients. Read More

Braz J Otorhinolaryngol 2018 Jun 11. Epub 2018 Jun 11.

Fudan University, Eye, Ear, Nose, and Throat Hospital, Department of Otolaryngology-Head and Neck Surgery, Shanghai, China; Shanghai Key Clinical, Disciplines of Otorhinolaryngology, Shanghai, China. Electronic address:

Introduction: There is still no general method for discriminating between benign and malignant leukoplakia and identifying vocal fold leukoplakia.

Objective: To evaluate the reliability of a morphological classification and the correlation between morphological types and pathological grades of vocal fold leukoplakia.

Methods: A total of 375 patients with vocal fold leukoplakia between 2009 and 2015 were retrospectively reviewed. Read More

APMIS 2018 Sep;126(9):732-738

Department of Pathomorphology, Medical University of Lodz, Lodz, Poland.

Overexpression of inhibitory checkpoint PD1/PD-L1 plays an important role in carcinogenesis and patients prognosis. 70 cases of oral squamous cell carcinoma (OSCC), 23 cases of oral leukoplakia (OLK), and 19 control cases were immunohistochemically stained with anti-PD-L1, -CD8, and -CD163 antibodies. PD-L1 was expressed on dysplastic and subepithelial infiltrating cells of OLK as well as on cancer and tumor-infiltrating cells of OSCC. Read More

Med J Islam Repub Iran 2018 16;32:23. Epub 2018 Mar 16.

Department of Preventive and Community Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, Indonesia.

Azo is a synthetic dye used in batik industries. It can be toxic to the tissue when exposed via inhalation, swallowing, or direct contact. Expression of cytokeratin will change in hyperplastic and cancer of the oral mucosa. Read More

J Oral Maxillofac Pathol 2018 May-Aug;22(2):281

Department of Oral Pathology, Mamata Dental College, Khammam, Telangana, India.

Background: Significant increase in cell proliferation and vascularity occurs during the transition from normal oral mucosa through differing degrees of dysplasia to oral squamous cell carcinoma (OSCC).

Aims: To evaluate the cell proliferation and vascularity in potentially malignant disorders and OSCC.

Settings And Design: Proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF) and CD34 were quantified immunohistochemically (IHC) using anti-PCNA, anti-VEGF and anti-CD34 antibody. Read More

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

World J Clin Oncol 2018 Aug;9(4):56-59

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

Quality of life (QoL) is a vital and often required health outcome measure that is relevant to patient care. A healthy oral cavity enables person to perform daily activities without any limitations. However, any disturbance may result in impaired QoL. Read More

Dermatol Online J 2018 Jun 15;24(6). Epub 2018 Jun 15.

Medical College of Georgia at Augusta University, Augusta, Georgia.

Background: It is important to better understand the role that environmental risk factors play on the development of esophageal cancer in Howel-Evans families. Additionally, there is little published about appropriate esophageal cancer screening practices in families genetically confirmed to have this condition.

Methods: Surveys were distributed to 47 addresses of an American family with Howel-Evans syndrome, of which 29 responded and met inclusion criteria. Read More

BMC Oral Health 2018 Aug 20;18(1):143. Epub 2018 Aug 20.

Department of Stomatology, Second Hospital of Tianjin Medical University, Ping-Jiang Road, He Xi District, 300211, Tianjin, People's Republic of China.

Background: There are different and inconsistent conclusions regarding the genetic relationship between the human tumor suppressor p53 (TP53) rs1042522 polymorphism and the risk of oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). Therefore, the aim of the study was to comprehensively reassess this association through the performance of an updated meta-analysis.

Methods: After searching the available databases, we systematically screened and included the eligible case-control studies, which contain the full genotype frequency data of the TP53 rs1042522 polymorphism for both OSCC/OL patients and the negative control groups. Read More

PLoS One 2018 20;13(8):e0202515. Epub 2018 Aug 20.

Psychosomatic Research Center and Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Studies have shown that stress-related catecholamines may affect cancer progression. However, little is known about catecholamine secretion profiles in head and neck cancer patients. The present study investigated plasma norepinephrine and epinephrine levels in head and neck squamous cell carcinoma (HNSCC) patients and patients with oral leukoplakia, as well as their association with clinicopathological and biobehavioral variables and anxiety symptoms. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jul;43(7):779-783

Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment.
 Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;53(8):631-635

Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Chengdu 610041, China.

Vocal cord leukoplakia is a clinical diagnosis defined as a whitish patch or a plaque on a mucosal surface. Because of the diversity of histopathological types, the complexity and unpredictability risks for malignant transformation, there are still many controversies about its histopathological classification, diagnosis and treatment. The aim of this article is to review the epidemiology, etiology, pathological classification, diagnosis, treatment and prognosis of vocal cord leukoplakia. Read More