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Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):201-205

Department of Stomatology, Affiliated Peace Hospital of Changzhi Medical College. Changzhi 046000,Shanxi Province, China.

Purpose: The objective of this study was to detect and analyze the existence of differential metabolites from saliva of patients with oral squamous cell carcinoma(OSCC) by metabonomics method, and to evaluate its application value on clinical diagnosis or screening of OSCC.

Methods: The collected saliva samples for OSCC patients, oral leukoplakiac(OLK) patients who were pathologically diagnosed and met the inclusion criteria were analyzed using metabonomics methods (GC-TOF-MS). The results were analyzed by principal component analysis and orthogonal partial least squares discriminant analysis using SIMCA software. Read More

Clin Exp Dent Res 2021 Jun 8. Epub 2021 Jun 8.

Centro de Investigaciones Odontológicas - Facultad de Odontología, Pontificia Universidad Javeriana, Bogotá, Colombia.

Objectives: To identify human papillomavirus (HPV), Epstein-Barr virus (EBV), and Candida albicans in oral leukoplakia with different degrees of dysplasia.

Materials And Methods: An observational, cross-sectional, descriptive study was performed using 30 formalin-fixed and paraffin-embedded tissues from patients with clinical suspicion of leukoplakia and confirmed diagnosis of oral dysplasia. Histological analyses were performed by two pathologists (interobserver) and dysplasias were classified as mild, moderate, or severe. Read More

Braz J Med Biol Res 2021 31;54(9):e10931. Epub 2021 May 31.

Beijing Institute of Dental Research, Beijing Key Laboratory, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University, Dongcheng District, Beijing, China.

Tobacco can induce reactive oxygen species (ROS) production extensively in cells, which is a major risk factor for oral leukoplakia (OLK) development. Peroxiredoxin 1 (Prx1) is a key antioxidant protein, upregulated in a variety of malignant tumors. We previously found that nicotine, the main ingredient of tobacco, promotes oral carcinogenesis via regulating Prx1. Read More

Diagnostics (Basel) 2021 May 26;11(6). Epub 2021 May 26.

Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Background: Oral leukoplakia is a potentially malignant lesion with a clinical impression similar to different benign and malignant lesions. Ex vivo fluorescence confocal microscopy is a developing approach for a rapid "chairside" detection of oral lesions with a cellular-level resolution. A possible application of interest is a quick differentiation of benign oral pathology from normal or cancerous tissue. Read More

Diagnostics (Basel) 2021 May 12;11(5). Epub 2021 May 12.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Oral leukoplakia (OL) has a propensity for recurrence and malignant transformation (MT). Herein, we evaluate sociodemographic, clinical, microscopic and immunohistochemical parameters as predictive factors for OL recurrence, also comparing primary lesions (PLs) with recurrences. Thirty-three patients with OL, completely removed either by excisional biopsy or by laser ablation following incisional biopsy, were studied. Read More

Medicina (Kaunas) 2021 May 1;57(5). Epub 2021 May 1.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

: Oral cancer is the 6th most common cancer in the world and oral leukoplakia is an oral potentially malignant disorder that could develop into oral cancer. This systematic review focusses on randomized clinical trials for recombinant adenovirus () therapy for the treatment of oral leukoplakia and cancer. : We searched for research articles on various databases such as Pubmed/Medline, Embase, CNKI (China National Knowledge Infra-structure), Springerlink, cochrane and Web of sciences from 2003 to 2020. Read More

Oral Oncol 2021 May 29;119:105362. Epub 2021 May 29.

Australian eHealth Research Centre, The Commonwealth Scientific & Industrial Research Organisation, Floreat, WA, Australia. Electronic address:

Objectives: Oral Lichenoid Dysplasia (OLD) is a controversial histological term applied to lesions that display features of oral lichen planus (OLP) and oral epithelial dysplasia (OED). In this study we investigated the molecular profiles of OLD, OLP and OED to determine whether OLD exists as a distinct pathological entity.

Materials And Methods: Samples from patients presenting with lesions diagnosed histologically as OLP, OLD or OED underwent RNA sequencing followed by differential gene expression, functional enrichment and network analysis, sparse partial least squares discriminant analysis, and immune cell phenotypic estimation. Read More

Head Neck Pathol 2021 May 31. Epub 2021 May 31.

Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02115, USA.

White lesions on the gingiva and palatal mucosa may represent reactive keratoses, including specific diseases such as benign alveolar ridge keratosis, or nonreactive keratoses, such as true leukoplakia, the latter being associated with a high recurrence rate at this site. The aim of this study is to determine the histopathologic features of gingival keratoses. Hyperkeratotic lesions from the gingiva, palatal mucosa, and alveolar ridge mucosa were available for evaluation after excluding specific keratotic lesions such as candidiasis. Read More

J Evid Based Dent Pract 2021 Mar 2;21(1):101531. Epub 2021 Feb 2.

Article Title And Bibliographic Information: Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis. de la Cour CD, Sperling CD, Belmonte F, Syrjänen S, Kjaer SK. Oral Dis. Read More

Clin Oral Investig 2021 May 29. Epub 2021 May 29.

Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Av. Primeira Avenida, s/n. Setor Leste Universitário, Goiânia, GO, CEP 74605-020, Brazil.

Objectives: The aim of this systematic review was to examine the evidence of the binary histologic grading system capacity for predicting malignant transformation and to compare it with that of the WHO systems.

Material And Methods: A systematic review was conducted, using PubMed, EMBASE, LILACS, Web of Science, Scopus, and LIVIVO databases without any language or timeframe restrictions. Studies were included if they compared the binary and the WHO histologic grading systems in the prediction of malignant transformation of oral epithelial dysplasia (OED). Read More

Mucosal Immunol 2021 May 26. Epub 2021 May 26.

Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, PR China.

Oral mucosal disease (OMD), which is also called soft tissue oral disease, is described as a series of disorders or conditions affecting the mucosa and soft tissue in the oral cavity. Its etiology is unclear, but emerging evidence has implicated the influence of the composition of the oral mucosa and saliva-resident microbiota. In turn, this dysbiosis effects the immune response balance and epithelial barrier function, followed by the occurrence and progression of OMD. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Mar 29:4603. Epub 2021 Mar 29.

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA; Center of Oral Pathology, StrataDx, Lexington, MA, USA; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.

Objective: Oral hairy leukoplakia (OHL) is a benign Epstein-Barr virus infection typically presenting as a white lesion on the lateral border of the tongue. Historically, OHL was described in patients who are severely immunocompromised, such as those with HIV/AIDS and organ transplant patients. OHL is increasingly seen in patients who are not severely immunocompromised. Read More

Med Oral Patol Oral Cir Bucal 2021 May 23. Epub 2021 May 23.

Department of Microbiology Faculty of Medical Sciences University of Sri Jayewardenepura Gangodawila, Nugegoda, Sri Lanka

Background: There is a debate as to whether some types of oral leucoplakias (OL) are caused by Candida species, and whether they contribute to the malignant transformation, associated with a minority of such lesions. As no detailed population analysis of yeast isolates from OL is available, we evaluated the virulence attributes, and genotypes of 35 C. albicans from OL, and compared their genotypes with 18 oral isolates from healthy individuals. Read More

Dermatol Ther (Heidelb) 2021 May 20. Epub 2021 May 20.

Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology (MSCNRIO), Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland.

Introduction: Chronic graft-versus-host disease (cGvHD) affects around half of allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients, with frequent involvement of the oral mucosa and lip vermillion, that clinically may resemble other autoimmune and inflammatory conditions. Our objectives were to define the dermoscopic patterns of lip vermilion in patients suffering from cGvHD and to compare the presentation with previously published dermoscopic presentations of other disease entities presenting on the lip vermillion.

Methods: A group of 16 patients diagnosed with cGvHD was assessed clinically and dermoscopically. Read More

N Engl J Med 2021 May;384(20):e75

King George's Medical University, Lucknow, India

Oral Dis 2021 May 19. Epub 2021 May 19.

Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.

Objectives: To investigate the available evidence on the malignant transformation (MT) of oral proliferative verrucous leukoplakia (PVL).

Material And Methods: We searched six main electronic and three grey literature databases in a two-phase process. Cohort studies investigating MT of PVL were eligible for inclusion. Read More

Appl Immunohistochem Mol Morphol 2021 May 17. Epub 2021 May 17.

Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS) Pathological Anatomy Service, University Hospital Complex of Santiago (CHUS), Santiago de Compostela Oral and Maxillofacial Pathology and Oral Medicine Unit, Department of Stomatology II, University of the Basque Country, Leioa, Spain Special Care Dentistry Centre (CAPE) and Oral Pathology, Department of Stomatology, University of São Paulo School of Dentistry (USP), São Paulo, Brazil.

Bcl-2 is a group of apoptotic proteins that play a key role in cellular homeostasis. Overexpression of Bcl-2 has been associated with the poor prognosis of oral squamous cell carcinoma (OSCC). The aim of this study is to analyze the immunohistochemical expression of Bcl-2 in healthy oral mucosa, different oral potentially malignant disorders and OSCC, and to determine its diagnostic value. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Mar 26. Epub 2021 Mar 26.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Medicine of West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objective: The objective of this study was to develop the first edition of a Chinese evidence-based position paper on the management of oral leukoplakia (OLK).

Study Design: The consultant group for drafting the position paper consisted of 31 oral medicine specialists and 2 evidence-based medicine specialists. English studies (searched in PubMed, EMBASE, and the Cochrane Library) and Chinese studies (searched in China National Knowledge Infrastructure and WanFang) published before January 2018 were used. Read More

Carcinogenesis 2021 May 16. Epub 2021 May 16.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in the head and neck with a poor prognosis. Oral cancer development is a multistep process involving carcinogenesis. Though significant advances in cancer immunotherapy over the years, there is lack of evidence for T cell exhaustion during oral carcinogenesis. Read More

J Clin Exp Dent 2021 May 1;13(5):e426-e432. Epub 2021 May 1.

Chairman of Oral Medicine. University of Valencia. Head of the Department of Stomatology and Maxillofacial Surgery University General Hospital. Valencia (Spain) Fundación de Investigación del Hospital General Universitario of Valencia, CIBERONC, Valencia, Spain.

The authors detected some minor errors in the published manuscript (Rubert A, Bagán L, Bagán JV. Oral leukoplakia, a clinical-histopathological study in 412 patients. J Clin Exp Dent. Read More

NPJ Genom Med 2021 May 12;6(1):32. Epub 2021 May 12.

National Institute of Biomedical Genomics, Kalyani, India.

Oral squamous cell carcinoma of the gingivo-buccal region (OSCC-GB) accounts for the highest cancer morbidity and mortality among men in India. It has been observed that about one-third of individuals with oral leukoplakia, a dysplastic precancerous lesion in the oral cavity, progress to oral cancer. We aimed to identify systematic transcriptomic changes as a normal tissue in the oral cavity progresses to frank OSCC-GB. Read More

J Cell Biochem 2021 May 10. Epub 2021 May 10.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

Although dysregulation and dysfunction of long noncoding RNAs (lncRNAs) have been implicated in malignant behavior of oral squamous cell carcinoma (OSCC), whether aberrant lncRNAs play a role in the carcinogenesis of oral leukoplakia (OL) as the best-known precursor of OSCC remains undetermined. Differentially expressed lncRNAs in the occurrence and progression of OL were studied by microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR). We found a novel key lncRNA n386251 that we named LOLA1 (lncRNA oral leukoplakia progressed associated 1) in the OL progression. Read More

Contemp Clin Dent 2021 Jan-Mar;12(1):37-43. Epub 2021 Mar 20.

Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental College and Hospital, Sir MVIT Campus, Bengaluru, Karnataka, India.

Introduction: Oral squamous cell carcinoma is usually preceded by potentially malignant disorders (PMDs), the most common being oral leukoplakia. A conservative management protocol is followed for milder dysplastic cases, while severe dysplastic lesions are surgically excised. Several classification systems have been developed based mainly on histopathological features with a lot of inter-observer variations. Read More

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):579. Epub 2021 Jan 9.

Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.

Background: Oral potentially malignant disorders (OPMDs) are a heterogenous group of disorders which precede the development of oral cancer. These are characterized by increased risk of malignant transformation to Oral cancer.

Aims & Objectives: In this study, an attempt has been made to assess the morphological alterations of the nuclei of the basal cells in OPMDs and oral squamous cell carcinoma (OSCC). Read More

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):578. Epub 2021 Jan 9.

Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana, India.

Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cavity and is commonly preceded by oral potentially malignant disorders. Glucose transporter-1 (GLUT-1) protein expression is upregulated in malignant cells that show increased glucose uptake. Alterations in GLUT-1 expression have been reported in several potentially malignant and malignant lesions. Read More

Transl Oncol 2021 Jul 1;14(7):101105. Epub 2021 May 1.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland; Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University in Kielce, PL-25317 Kielce, Poland. Electronic address:

Oral leukoplakia is a clinical term relating to various morphological lesions, including squamous cell hyperplasia, dysplasia and carcinoma. Leukoplakia morphologically manifested as hyperplasia with epithelial dysplasia is clinically treated as precancerous condition. Nevertheless, there is a lack of good markers indicating the transformation of premalignancies towards cancer. Read More

Rambam Maimonides Med J 2021 Apr 29;12(2). Epub 2021 Apr 29.

Oral and Maxillofacial Surgery, Asan Memorial Dental College and Hospital, Keerapakkam Village, Asan Nagar, Chengalpattu, India.

Objective: The aim of this study was to compare and correlate mast cell density (MCD) and microvessel density (MVD) between normal oral mucosa, oral lichen planus, various grades of dysplasia, and oral squamous cell carcinoma (OSCC).

Materials And Methods: The study comprised a total of 75 samples, of which 65 were archival tissue blocks of histopathologically confirmed cases, which included 10 cases of oral lichen planus, 25 cases of dysplasia (mild [n=10], moderate [n=10], and severe [n=5]), and 30 cases of OSCC (well differentiated [n=10], moderately differentiated [n=10], and poorly differentiated [n=10]), and 10 samples of normal oral mucosa. All the sections were immunohistochemically stained with anti-CD34 and counterstained with toluidine blue stain. Read More

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.

This study aimed to investigate the role of a panel of salivary cytokines as biomarkers for early detection oral squamous cell carcinoma (OSCC), comparing their levels among healthy individuals, patients with oral leukoplakia (OL), and malignant lesions. Cytokine profiling analysis performed in a minimally invasive sample was correlated with clinicopathological variables in our patient cohorts. Unstimulated saliva was obtained from subjects with OSCC at early ( = 33) and advanced ( = 33) disease, OL with homogeneous ( = 33) and proliferative verrucous ( = 33) clinical presentations, and healthy controls ( = 25). Read More

Oral Dis 2021 Apr 29. Epub 2021 Apr 29.

Pontifícia Universidade Católica do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba-PR, 80215-901, Brazil.

PLoS One 2021 29;16(4):e0251017. Epub 2021 Apr 29.

Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.

Background: Certain oral bacterial pathogens may play a role in oral carcinogenesis. We assessed the feasibility of conducting a population-based study in India to examine the distributions and levels of Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia in relation to oral leukoplakia (a potentially malignant disorder) and other participant characteristics.

Methods: This exploratory case-control study was nested within a large urban Indian cohort and the data included 22 men and women with oral leukoplakia (cases) and 69 leukoplakia-free controls. Read More