Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats.
- Vitor Bonetti Valente,
- Flávia Alves Verza,
- Felipe Yudi Kabeya Lopes,
- Joana Zafalon Ferreira,
- Paulo Sérgio Patto Dos Santos,
- Maria Lúcia Marçal Mazza Sundefeld,
- Éder Ricardo Biasoli,
- Glauco Issamu Miyahara,
- Ana Maria Pires Soubhia,
- Mariza de Andrade,
- Sandra Helena Penha de Oliveira,
- Daniel Galera Bernabé
Psychoneuroendocrinology 2017 Nov 8. Epub 2017 Nov 8.
Psychoneuroimmunology Research Center, Oral Oncology Center, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St., SP 15050-015, Araçatuba, São Paulo, Brazil; Department of Pathology and Clinical Propedeutics, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St., SP 15050-015, Araçatuba, São Paulo, Brazil. Electronic address:
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction. Read More