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    [MALT lymphoma with t (X;14) (p11.2;q32) developing during the course of cutaneous leukocytoclastic angitis].
    Rinsho Ketsueki 2018 ;59(3):269-274
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine.
    A 73-year-old man with left parotid gland swelling over 2 months was referred to our hospital in March 201X. Purpura on the lower legs had been recurrent for >20 years. Biopsy of the parotid gland demonstrated diffuse infiltration of abnormal lymphocytes that were negative for CD10 and positive for CD19, CD20, and κ-chain. Read More
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    A Case of Crescentic Glomerulonephritis Complicated with Hypocomplementemic Urticarial Vasculitis Syndrome and ANCA-Associated Vasculitis.
    Case Rep Nephrol Dial 2017 Sep-Dec;7(3):144-153. Epub 2017 Nov 27.
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
    Systemic urticaria in a 64-year-old woman was diagnosed as leukocytoclastic vasculitis by a punch biopsy of the skin. Her physical findings improved after prescription of prednisolone at a dose of 20 mg/day, but the skin rash relapsed with renal dysfunction, proteinuria, and hematuria when the dose of prednisolone was reduced over a period of 9 months to 1 mg/day. She was admitted to our institute for further examination, when urinary protein and plasma creatinine levels were 0. Read More
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    A Rare Case of Eosinophilic Granulomatosis with Polyangiitis Associated with Cryoglobulinemia Presenting with a Bullous Skin Eruption of the Lower Limbs.
    Case Rep Med 2018 16;2018:3124281. Epub 2018 Jan 16.
    University Medical Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.
    Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is an antineutrophil cytoplasmic antibody- (ANCA-) associated small vessel vasculitis with multisystem involvement. It is characterized with asthma, eosinophilia, and renal and peripheral nervous system involvement. However, EGPA presenting with bullous skin eruption is an uncommon dermatological manifestation. Read More
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    Henoch-Schönlein purpura in the third trimester of pregnancy.
    Biochem Med (Zagreb) 2018 Feb 10;28(1):010801. Epub 2018 Jan 10.
    Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
    Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessels' vasculitis that affects the skin, intestines and kidneys. Pregnancy has been reported as an exacerbating factor. We present the case of a 24-year-old with HSP that occurred in the third trimester and lasted up to the end of the successful delivery. Read More
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    Complete resolution of erythema elevatum diutinum using oral sulfasalazine.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Harvard University, Cambridge, Massachusetts, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. michael_
    Erythema elevatum diutinum (EED) is a rare, chronic small-vessel vasculitis that presents as firm, red, violaceous, or brown papules and nodules on the extensor surfaces of the limbs. Oral dapsone is considered first-line therapy for EED; in the current case report, a patient presenting with EED began dapsone treatment and symptoms subsided within two weeks. Seven months later, the patient became pregnant and stopped dapsone owing to her concerns with dapsone use during pregnancy, resulting in recurrence of EED symptoms. Read More
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    A case of probable trimethoprim-sulfamethoxazole induced circulating antineutrophil cytoplasmic antibody-positive small vessel vasculitis.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology, University of Illinois College of Medicine at Peoria, Peoria, Illinois.
    Cutaneous leukocytoclastic vasculitis (LCV) can occur as skin-limited disease or as part a systemic vasculitis. Appropriate workup includes the evaluation of antineutrophil cytoplasmic antibodies (ANCAs), with a positive titer raising concern for the associated primary vasculitides including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), or eosinophilic granulomatosis with polyangiitis (EGPA). In the absence of systemic findings, however, a drug etiology must also be considered. Read More
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    A case of leukocytoclastic vasculitis caused by novel anticoagulant rivaroxaban.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    McGovern Medical School, Houston, Texas.
    Cutaneous leukocytoclastic vasculitis (LCV) is type of small vessel vasculitis that commonly presents as palpable purpura involving the lower extremities and buttocks. Approximately half of cases are idiopathic, but the disease may be triggered by infection, drug reaction, inflammatory disease, or other causes. We report a case of leukocytoclastic vasculitis secondary to the novel anticoagulant rivaroxaban (Xarelto®). Read More
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    Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis.
    J Community Hosp Intern Med Perspect 2018 6;8(1):35-37. Epub 2018 Feb 6.
    Department of Medicine/Division of Rheumatology, University of Tennessee College of Medicine, Chattanooga, TN, USA.
    Propylthiouracil (PTU) is a commonly used medication for the treatment of hyperthyroidism. PTU is known to cause different adverse reactions including autoimmune syndromes. PTU-induced autoimmune syndromes can be classified into drug-induced lupus or drug-induced vasculitis. Read More
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    Histologic Features of Gastrointestinal Tract Biopsies in IgA Vasculitis (Henoch-Schönlein Purpura).
    Am J Surg Pathol 2018 Apr;42(4):529-533
    Departments of Pathology.
    Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura (HSP) typically occurs in the pediatric population, although rare cases also occur in adults. Gastrointestinal (GI) involvement is common. The "classic" histologic finding in IgA vasculitis (HSP) is leukocytoclastic vasculitis (LCV); other histologic features in biopsies of IgA vasculitis (HSP) have only been rarely described. Read More
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    Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: A Clinical-Pathophysiological Analysis.
    Am J Ophthalmol 2018 Apr 6;188:131-140. Epub 2018 Feb 6.
    Associated Retinal Consultants, PC, Royal Oak, Michigan; Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Rochester, Michigan. Electronic address:
    Purpose: To derive novel insights into the pathophysiology of vancomycin-related hemorrhagic occlusive retinal vasculopathy (HORV) through a careful clinicopathologic correlation.

    Methods: We retrospectively reviewed the clinical and pathologic course of 2 consecutive patients who developed HORV. The clinical history, multimodal imaging, ultrasound biomicroscopy (UBM), and intraoperative and histologic findings are reported. Read More
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    Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis.
    Am J Med Sci 2018 Feb 8;355(2):195-200. Epub 2017 Apr 8.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
    Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disease characterized by multiple organ system involvement, including renal disease, with low complement levels. We report the case of a 31-year-old woman who presented with nonspecific symptoms including fatigue, diarrhea, macular rash and abdominal pain with acute renal failure leading to end-stage kidney disease. Laboratory results showed hematuria, nephrotic range proteinuria, worsening creatinine and low C1q levels. Read More
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    Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis of a Multidisciplinary Approach.
    Case Rep Oncol 2017 Sep-Dec;10(3):1041-1049. Epub 2017 Nov 27.
    Dermatology Department, Instituto CUF de Oncologia (I.C.O.), Lisbon, Portugal.
    In phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. Read More
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    Histopathologic Finding of Perieschar Lesions in Tsutsugamushi Disease Shows Lymphocytic Vasculitis Mimicking Angiocentric Lymphoma.
    Ann Dermatol 2018 Feb 26;30(1):29-35. Epub 2017 Dec 26.
    Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
    Background: Tsutsugamushi disease is an acute, febrile, infectious disease caused by . Several studies investigating the histopathologic findings of eschars in tsutsugamushi disease reported leukocytoclastic vasculitis and neutrophil infiltration as the major findings. However, these findings may result from secondary changes following tissue necrosis. Read More
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    Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection.
    PLoS One 2018 30;13(1):e0190617. Epub 2018 Jan 30.
    Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
    Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Read More
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    Non-hemorrhage-related adverse effects of rivaroxaban.
    Arch Med Sci Atheroscler Dis 2017 31;2:e108-e112. Epub 2017 Dec 31.
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
    The direct oral anticoagulant rivaroxaban is useful in various indications that include venous deep vein thrombosis prophylaxis/treatment after knee/hip replacement surgery and prevention of stroke in patients with non-valvular atrial fibrillation. Its mechanism of action has been mostly associated with hemorrhage-related adverse effects; thus a number of non-hemorrhage-related adverse effects of the drug have received less attention or go unrecognized. These adverse effects mainly include liver injury, hypersensitivity reactions, leukocytoclastic vasculitis and hair loss. Read More
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    Cutaneous and systemic vasculitides in dermatology: a histological perspective.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):185-193. Epub 2018 Jan 24.
    Unit of Dermatology, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.
    Cutaneous vasculitides encompass a wide and heterogeneous group of diseases affecting skin blood vessels that are clinically characterized by polymorphic skin lesions, particularly including palpable purpura as well as urticarial and necrotic-ulcerative lesions, with possible, albeit rare, extracutaneous involvement. Cutaneous leukocytoclastic angiitis and urticarial vasculitis, which are the two prototypic and most common variants of this group, are usually idiopathic but may also be induced by different triggers, notably drugs and infections, or may manifest in association with systemic disorders, particularly lupus erythematosus. Vasculitis skin lesions can also occur during the chronic-relapsing course of systemic vasculitides, such as granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis, with which cutaneous vasculitides can share clinical and histological features. Read More
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    Neutrophilic dermatoses: a broad spectrum of disease.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):265-272. Epub 2018 Jan 24.
    Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -
    The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More
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    Cutaneous hemophagocytosis: Clinicopathologic features of 21 cases.
    J Am Acad Dermatol 2018 Feb;78(2):377-382
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:
    Background: Hemophagocytosis is well known in cytotoxic cutaneous T-cell lymphomas (CTCLs), in which it may represent a sign of hemophagocytic lymphohistiocytosis syndrome (HLHS), and is also typical of cutaneous Rosai-Dorfman disease (cRDD) (without prognostic relevance). Only rarely, has cutaneous hemophagocytosis (CH) been described in other skin conditions.

    Objective: To characterize the clinicopathologic features of CH in skin biopsy specimens from patients with conditions other than CTCL or cRDD. Read More
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    Late-Stage Erythema Elevatum Diutinum Mimicking a Fibroblastic Tumor: A Potential Pitfall.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Dermatopathology Department, Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.
    Erythema elevatum diutinum (EED) is a rare dermatosis with evolving histopathological features that vary according to the age of the lesions, with a variable fibrosis and a fascicled proliferation of spindle cells in late phases. The authors present an otherwise healthy 57-year-old woman with multiple indurated nodules on the inner aspect of both feet. Skin biopsy showed storiform interlacing bundles of spindled cells with plump nuclei and some areas with neutrophils and leukocytoclasia. Read More
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    [Humoral immune diseases: Cutaneous vasculitis and auto-immune bullous dermatoses].
    Ann Pathol 2018 Feb 27;38(1):31-42. Epub 2017 Dec 27.
    Département de pathologie, service d'anatomie et de cytologie pathologiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:
    Humoral immunity is the cause of multiple diseases related to antibodies (IgA, IgG, IgM) produced by the patient. Two groups of diseases are identified. The first group is related to circulating antigen-antibody complexes. Read More
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    Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis.
    Int Ophthalmol 2017 Dec 18. Epub 2017 Dec 18.
    Dalmia Ophthalmic Pathology Services, L V Prasad Eye Institute, Bhubaneswar, India.
    Introduction: To report a case of retinal vasculitis associated with cutaneous leukocytoclastic vasculitis.

    Methods: Retrospective chart review.

    Results: A 28-year-old man, who initially presented with occlusive retinal vasculitis and vitreous hemorrhage in right eye that resolved with sectoral photocoagulation. Read More
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    Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review.
    J Cutan Pathol 2018 Feb 11;45(2):167-170. Epub 2017 Dec 11.
    Department of Pathology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.
    Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a histopathological diagnosis, characterized by a pattern of granulomatosis, which may be associated with leukocytoclastic vasculitis. PNGD most commonly occurs in association with systemic inflammatory disorders, typically autoimmune conditions, such as rheumatoid arthritis and systemic lupus erythromatosus. There are very rare reports of PNGD in patients with lymphoma. Read More
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    IgA Vasculitis with Simultaneous Cardiopulmonary Involvement.
    Intern Med 2018 Mar 8;57(6):829-834. Epub 2017 Dec 8.
    Division of Cardiology, Department of Medicine II, Kansai Medical University, Japan.
    A 60-year-old man with a history of hypertension, type 2 diabetes, and reflux esophagitis was admitted to our hospital with hemoptysis, dyspnea, and leg edema. We diagnosed him with adult IgA vasculitis based on the presence of purpura, elevated serum IgA fibronectin complexes, pathophysiological findings, a skin biopsy showing leukocytoclastic vasculitis, and immunofluorescence studies demonstrating granular IgA and C3 deposits in the blood vessel wall. He showed concurrent cardiopulmonary involvement without involvement of the gastrointestinal system and kidneys, which are commonly affected in IgA vasculitis patients. Read More
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    Leukocytoclastic vasculitis complicating cisplatin + radiation treatment for laryngeal cancer: a case report.
    BMC Cancer 2017 12 6;17(1):831. Epub 2017 Dec 6.
    School of Medical Sciences (FCM), University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo Street, Campinas, SP, 13083-8871, Brazil.
    Background: Leukocytoclastic vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, leukocytoclastic vasculitis related to cisplatin has not yet been described in the scientific literature.

    Case Presentation: We report a rare case of leukocytoclastic vasculitis after the first cycle of high-dose cisplatin chemotherapy in a patient with larynx carcinoma. Read More
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    Vasculitis: Kids are not just little people.
    Clin Dermatol 2017 Nov - Dec;35(6):530-540. Epub 2017 Aug 4.
    Department of Dermatology Lahey Clinic, Burlington, MA.
    Cutaneous vasculitis, inflammatory destruction of blood vessels, can present with a wide range of clinical and pathologic findings across a number of heterogeneous conditions. Although some vasculitides are present in both children and adults, some important differences exist in clinical presentation, etiology, management, and prognosis in childhood vasculitis versus adult vasculitis. Cutaneous vasculitis is rare in children, and most childhood vasculitides, of which Henoch-Schönlein purpura is the most common, histologically are small vessel leukocytoclastic vasculitis. Read More
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    Posterior reversible encephalopathy syndrome in IgA vasculitis: Neuroimaging of a 14-year-old child.
    Neurol Neurochir Pol 2018 Jan - Feb;52(1):107-111. Epub 2017 Nov 14.
    Department of Brain Surgery, Van Yuzuncu Yıl University, Dursun Odabası Faculty of Medicine, Van, Turkey. Electronic address:
    IgA vasculitis (IgAV) is a leukocytoclastic vasculitis and characterized by involvement of small vessels in skin, gastrointestinal system, joints, kidneys, and less frequently other organs. It is the commonest vasculitis in childhood and etiology is not completely known. Neurological manifestations of IgAV are very rare and usually seen in patients with severe hypertension or as an uncommon feature such as peripheral neuropathy. Read More
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    Vanishing vasculitis: a case of acute necrotic skin findings without pathologic features of vasculitis from adulterated cocaine.
    J Community Hosp Intern Med Perspect 2017 18;7(5):321-324. Epub 2017 Oct 18.
    Internal Medicine Residency Program, St. Elizabeth Youngstown Hospital, Youngstown, OH, USA.
    While the usage of illicit drugs in itself carries significant health risks and associated toxicities, drugs that are adulterated to give them volume, alter their psychogenic properties, and make them cheaper to produce are to be considered even more dangerous. Cocaine is one of them, and it is now most commonly being adulterated with levamisole. We report a case of a 37-year-old female with the chief complaint of painful skin lesions and wounds on both of her upper and lower extremities for three weeks duration. Read More
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    Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura.
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Nov 2. Epub 2017 Nov 2.
    Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
    Background: Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of IgA immune complexes. An association between HSP and atypical bacteria is uncommon in children.

    Methods And Results: Here we report three cases of children, aged 5, 4 and 16 years, who were diagnosed with HSP associated with Mycoplasma pneumoniae or Chlamydia pneumoniae infection. Read More
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    [Acute hemorrhagic edema of infancy: alarming lesions of a benign condition. Case report].
    Arch Argent Pediatr 2017 12;115(6):e432-e435
    Salud total EPS, Urbanización El Bosque.
    We report a case of acute hemorrhagic edema of infancy in an 18-month-old boy after an episode of otitis media. The clinical presentation begins with skin erythematous macules on the thighs, followed by purpuric lesions in arms, legs, and ankle edema. It was initially interpreted as urticaria, whereby steroids were indicated. Read More
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    Late-stage nodular erythema elevatum diutinum mimicking sclerotic fibroma.
    J Cutan Pathol 2018 Jan 22;45(1):94-96. Epub 2017 Nov 22.
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
    Erythema elevatum diutinum (EED) is a rare, cutaneous vasculitis of uncertain origin. EED can present clinically as chronic bilateral, symmetrical, periarticular papules, plaques and nodules. We report here an unusual case of EED presenting as multiple, densely fibrosing nodules on the feet of a 60-year-old human immunodeficiency virus positive woman. Read More
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    Leukocytoclastic vasculitis presenting in association with Coxiella burnetii (Q fever): A case report.
    J Cutan Pathol 2018 Jan 20;45(1):71-73. Epub 2017 Nov 20.
    Department of Pathology and Dermatopathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
    Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41-year-old male complaining of body ache, fever, nausea, malaise, bilateral knee pain and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Read More
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    Tenofovir-induced Leukocytoclastic Vasculitis.
    Oman Med J 2017 Sep;32(5):429-431
    Department of Medicine, Division of Gastroenterology and Hepatology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
    Tenofovir, a nucleotide analog, is one of the first-line medications recommended for the treatment of active chronic hepatitis B virus infection (CHB) and as a primary prophylaxis to prevent hepatitis B reactivation in cases of immunosuppression. We report the first case of tenofovir-induced leukocytoclastic vasculitis (LCV). A 43-year-old obese woman, who was known to have inactive CHB, was diagnosed with chronic immune thrombocytopenic purpura (ITP). Read More
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    Direct immunofluorescence testing in vasculitis-A single institution experience with Henoch-Schönlein purpura.
    J Cutan Pathol 2018 Jan 8;45(1):16-22. Epub 2017 Nov 8.
    Departments of Pathology and Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
    Background: Direct immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results.

    Methods: Cases submitted for DIF and histology (2010-2014) with "vasculitis" in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of Henoch-Schönlein purpura (HSP). Peri/intravascular IgA was considered positive, other reactants non-specific and no immunoreactivity negative. Read More
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    Outline of guidelines for the management of vasculitis and vascular disorders in Japan, 2016 revised edition.
    J Dermatol 2018 Feb 6;45(2):122-127. Epub 2017 Oct 6.
    Department of Dermatology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
    The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name. Read More
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