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Case Rep Pediatr 2021 20;2021:1996430. Epub 2021 May 20.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Nicklaus Children's Hospital, Miami, FL, USA.

Inflammatory bowel disease (IBD) that presents in children <6 years of age is known as very early-onset IBD (VEO-IBD). Extraintestinal manifestations in IBD, such as erythema nodosum (EN), pyoderma gangrenosum (PG), and, less likely, leukocytoclastic vasculitis (LV), are more commonly present in Crohn's disease. Association between LV and ulcerative colitis (UC) is not commonly seen. Read More

Actas Dermosifiliogr 2021 Jun 17;112(6):556-557. Epub 2021 Mar 17.

Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Valencia, Spain.

Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Cockerell Dermatopathology, Dallas, TX; Icahn School of Medicine at Mount Sinai, New York, NY; Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX; Department of Pathology, Veterans Affairs North Texas Health Care System, Dallas, TX; Department of Pathology, UT Southwestern Medical Center, Dallas, TX; Dermatology and Skin Surgery Clinic, Alexandria, LA; Department of Dermatology, UT Southwestern Medical Center, Dallas, TX; and Rheumatology Section, Veterans Affairs North Texas Health Care System, Dallas, TX.

Abstract: Leukocytoclastic vasculitis (LCV) is a small vessel inflammatory condition considered to be caused by circulating immune complexes and often occurs after an acute infection or exposure to a new medication, although it may be associated with an underlying systemic disease or be idiopathic in nature. It is important to determine the etiology, identify the extent of the disease for early intervention and appropriate management, and treat and/or eliminate the underlying cause. Here, we report cases of scurvy and tinea corporis that presented with histopathologic features of LCV and had significant clinical improvement with treatment of the underlying etiologies. Read More

Clin Case Rep 2021 May 9;9(5):e03872. Epub 2021 Apr 9.

Department of Dermatology Mayo Clinic Florida Jacksonville FL USA.

Recognize that delayed hypersensitivity reactions to sulfonamides may present as urticated plaques with hyperpigmentation and purpura for which a diagnosis of urticarial vasculitis should be considered. Read More

Surg Pathol Clin 2021 Jun 28;14(2):309-325. Epub 2021 Apr 28.

Department of Dermatology, Yale University, 333 Cedar Street, PO Box 208059, New Haven, CT 06520, USA; Department of Pathology, Yale University, 310 Cedar St, New Haven, CT 06511, USA.

Although clinicians often put vasculitis and microvascular occlusion in the same differential diagnosis, biopsy findings often are either vasculitis or occlusion. However, both vasculitis and occlusion are present in some cases of levamisole-associated vasculopathy and certain infections. Depth of dermal involvement and vessel size should be reported, because superficial and deep small vessel leukocytoclastic vasculitis and/or involvement of medium-sized vessels may be associated with systemic disease. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211017413

Emory University, Atlanta, GA, USA.

Acute hemorrhagic edema of infancy (AHEI) is a cutaneous leukocytoclastic vasculitis presenting with purpura, ecchymosis, fever, and edema. Pediatricians must effectively differentiate AHEI from other diseases that have similar presentations but are more severe in order to treat appropriately without overutilizing expensive, unnecessary diagnostic tests. In this article, we describe a case of a 6-month-old previously well male who presented to our institution with a worsening rash and fever. Read More

Am J Ophthalmol Case Rep 2021 Jun 22;22:101100. Epub 2021 Apr 22.

Clinical Institute of Ophthalmology, Hospital Clinic of Barcelona, Barcelona, Spain.

Purpose: To describe a case series of scleritis associated with IgA vasculitis (IgAV) at a tertiary referral center.

Observations: Three men with scleritis associated with IgAV were identified: one with anterior scleritis alone, one with anterior scleritis and peripheral ulcerative keratitis (sclerokeratitis), and one with anterior and posterior scleritis. Visual acuity was preserved except from the patient who developed posterior scleritis. Read More

Transfus Apher Sci 2021 May 6:103157. Epub 2021 May 6.

Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address:

Introduction: Cutaneous leukocytoclastic vasculitis is an inflammatory variant of vasculitis with a variety of causes that only affects the skin. Its pathological manifestations include neutrophil infiltration and nuclear fragmentation. Clinically, it is characterised by a pleomorphic rash, including erythema, purpuric skin lesions, reticulocytosis, necrosis and ulceration. Read More

Drug Saf 2021 May 6. Epub 2021 May 6.

Department of Dermatology, San Gallicano Dermatological Institute-IRCCS, Via Elio Chianesi 53, 00144, Rome, Italy.

Three cyclin-dependent kinases 4/6, including palbociclib, ribociclib, and abemaciclib, have been approved for the treatment of patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer. The objective of this study was to evaluate the occurrence and clinical spectrum of cutaneous adverse events in patients with breast cancer following therapy with cyclin-dependent kinase 4/6 inhibitors. A systematic literature search was performed in the PubMed, Cochrane, and EMBASE databases up to November 2020 to evaluate studies published from 2015 to 2020. Read More

J Inflamm Res 2021 28;14:1661-1666. Epub 2021 Apr 28.

Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

We presented a case of hepatitis B virus (HBV)-related type III cryoglobulinemia vasculitis (CryoVas) characterized by extremity gangrene in a patient with diabetes. The 60-year-old female had a 10-year history of poorly controlled type 2 diabetes mellitus. She complained of sudden onset pain and swelling of toes which quickly progressed to gangrene, with fingers becoming pain and dark violet. Read More

Clin Transl Allergy 2021 Apr;11(2):e12031

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Urticarial vasculitis (UV) is defined by long-lasting urticarial lesions combined with the histopathologic findings of leukocytoclastic vasculitis. As one of the major unmet needs in UV, diagnostic criteria are rather vague and not standardized. Moreover, there seems to be considerable overlap with chronic spontaneous urticaria (CSU), particularly for the normocomplementemic variant of UV. Read More

JAAD Case Rep 2021 May 29;11:81-83. Epub 2021 Mar 29.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Cureus 2021 Mar 29;13(3):e14165. Epub 2021 Mar 29.

Internal Medicine, Henry Ford Health System, Detroit, USA.

Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV in a patient with reactivated hepatitis C. Read More

Int J Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, Tufts Medical Center, Boston, MA, USA.

Ann Dermatol 2021 Feb 30;33(1):73-76. Epub 2020 Dec 30.

Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, Korea.

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption and characterized histopathologically by the presence of granulomatous inflammation with or without leukocytoclastic vasculitis. PNGD is known to be associated with various immune-mediated connective tissue diseases such as rheumatoid arthritis and lupus erythematosus. However, to our knowledge, a case of PNGD in a patient with Behçet's disease is extremely rare and only one case has been reported in foreign literature to date. Read More

Ann Dermatol 2020 Apr 11;32(2):164-167. Epub 2020 Mar 11.

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. Read More

Int J Rheum Dis 2021 Jun 22;24(6):789-794. Epub 2021 Apr 22.

Department of Clinical Biochemistry, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Aim: Immunoglobulin A vasculitis (IgAV) is classified as a leukocytoclastic vasculitis characterized by immune deposits in endothelial walls of small vessels causing vascular endothelial injury. The aim of the present study is to evaluate levels of vascular endothelial growth factor-A (VEGF-A) and VEGF receptor-1 (VEGFR-1) levels in adult IgAV patients.

Method: Thirty-seven adult IgAV patients admitted to the Rheumatology Clinic meeting the IgAV American College of Rheumatology (ACR) criteria and 32 control subjects were enrolled in the study. Read More

Childs Nerv Syst 2021 Apr 17. Epub 2021 Apr 17.

Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.

Purpose: Pediatric low-grade gliomas are the most frequent brain tumors in children. The standard approach for symptomatic unresectable tumors is chemotherapy. Recently, key molecular alterations/pathways have been identified and targeted drugs developed and tested in clinical trials. Read More

Cureus 2021 Mar 13;13(3):e13863. Epub 2021 Mar 13.

Department of Internal Medicine, Suzu General Hospital, Suzu, JPN.

We present the case of a 79-year-old man on hemodialysis with immunoglobulin A (IgA) vasculitis. He developed palpable purpura three weeks after having pneumonia. A skin biopsy showed leukocytoclastic vasculitis with IgA and C3 deposition. Read More

Acta Derm Venereol 2021 May 4;101(5):adv00449. Epub 2021 May 4.

Skin and Endothelium Research Division (SERD), Department of Dermatology, Medical University of Vienna, AT-1090 Vienna, Austria.

Clinical differential diagnosis of arteriolosclerotic ulcers of Martorell is challenging due to the lack of clearly affirmative instrument-based diagnostic criteria. The aim of this study was to develop vascular histomorphological diagnostic criteria differentiating Martorell ulcers from other types of leg ulcers. The histomorphology of patients diagnosed with arteriolosclerotic ulcers of Martorell (n = 67) was compared with that of patients with venous leg ulcers, necrotizing leukocytoclastic vasculitis, pyoderma gangrenosum, and non-ulcerative controls (n = 15 each). Read More

IDCases 2021 6;24:e01117. Epub 2021 Apr 6.

Rashid Hospital, Internal Medicine Department, Umm Hurair 2, Dubai, United Arab Emirates.

A 41-year-old male with type 2 diabetes mellitus (T2DM) presented with complaints of recent onset limb weakness, diffuse body rash and fever. Computerized Tomography (CT) scan of the brain did not reveal a stroke but laboratory investigations of the patient portrayed multi-systemic involvement. Naso-pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was taken which resulted as positive. Read More

Neurol Neuroimmunol Neuroinflamm 2021 05 9;8(3). Epub 2021 Apr 9.

From the Department of Neurology (L.R., S.P., M.P., T.R., H.W.), Institute of Translational Neurology, University Hospital of Münster, Germany; Department of Neurology (J.H., C.K., R.P.), University Hospital Essen, University Duisburg-Essen, Essen, Germany; Department of Dermatology (W.S.), University Hospital Essen, University Duisburg-Essen, Essen, Germany; and Department of Neurology (M.K., S.G.M.), University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany.

Objective: To report 77 patients with multiple sclerosis (MS) who developed skin-related adverse events (AEs) following treatment with cladribine.

Methods: We evaluated our prospective bicentric cladribine cohort. Cladribine-treated patients with a skin AE were identified. Read More

Leuk Res 2021 May 30;104:106571. Epub 2021 Mar 30.

Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland. Electronic address:

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Paediatrics, Case Western Reserve University Hospital, Cleveland, Ohio, USA.

The current case report describes a 13-year-old young boy who presented with purpuric rashes following a completely asymptomatic COVID-19 infection and biopsy-confirmed leucocytoclastic vasculitis, mild haematuria and mild elevation of serum IgA. This case highlights one of the dermatological manifestations of COVID-19 infection which has not been reported so far. Paediatricians should explore the history of this infection when evaluating any child presenting with a vasculitic rash. Read More

JAAD Case Rep 2021 Apr 4;10:72-74. Epub 2021 Feb 4.

University of Texas Medical Branch, Department of Dermatology, Galveston, Texas.

Cureus 2021 Feb 24;13(2):e13533. Epub 2021 Feb 24.

General Surgery, Lebanese American University-Medical Center, Beirut, LBN.

Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis with cutaneous, articular, gastrointestinal, and renal manifestations. Leukocytoclastic vasculitis and IgA deposits are classically found when involved skin and kidneys are biopsied. The disease's etiology remains unknown, although many bacterial and viral infections have been described as triggering factors. Read More

Radiol Cardiothorac Imaging 2020 Dec 19;2(6):e200406. Epub 2020 Nov 19.

Department of Radiology (M.H., T.W., G.S., C.A., B.S., J.B., A.W.S.), Department of Research & Analytic Services (M.H., T.W., F.F., B.S.), and Division of Histopathology and Autopsy, Institute of Pathology (K.M., J.H., T.M., A.T.), University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland; and Department of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland (M.H., N.S., A.M., K.D.M.).

Purpose: The purpose of this retrospective study was to correlate CT patterns of fatal cases of coronavirus disease 2019 (COVID-19) with postmortem pathology observations.

Materials And Methods: The study included 70 lung lobes of 14 patients who died of reverse-transcription polymerase chain reaction-confirmed COVID-19. All patients underwent antemortem CT and autopsy between March 9 and April 30, 2020. Read More

J Coll Physicians Surg Pak 2021 Mar;31(3):350-352

Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.

Henoch-Schönlein Purpura (HSP) is an autoimmune, systemic, non-granulomatous vasculitis characterised by self-limiting clinical course, and leukocytoclastic vasculitis of small vessels. Deposition of immune complexes that contain IgA is the hallmark of vascular involvement. Adults with HSP have a higher incidence of complications and death. Read More

Cureus 2021 Feb 14;13(2):e13338. Epub 2021 Feb 14.

Internal Medicine, All India Institute of Medical Sciences, Bhubaneswar, IND.

Schnitzler syndrome (SS) is a rare disease of unknown etiology. Literature suggests that only around 300 well-diagnosed cases have only been reported worldwide and rarely from India. This syndrome has a slight male predominance with a mean age of onset of around 50 years. Read More

Int J Low Extrem Wounds 2021 Mar 20:1534734621999029. Epub 2021 Mar 20.

University of Campania "Luigi Vanvitelli", Naples, Italy.

Prevalence of nonhealing ulcers of lower extremities has increased over years causing heavy health, social, and economic burdens. Chronic ulcers are difficult to treat since they require tailored multistep treatment and patient compliance. To treat chronic wounds successfully, clinicians must keep in mind the ulcer etiology as well as the underlying diseases. Read More