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Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):83-87

Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Cutaneous vasculitis is a recognized and potentially serious adverse event of immunization with several vaccines, and COVID-19 vaccines are no exception. We present a case of cutaneous leukocytoclastic vasculitis occurring 17 days after inoculation with adenoviral vector vaccine (Ad26.COV2. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):89-92

Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Cutaneous vasculitis is a recognized and potentially serious adverse event of immunization with several vaccines, and COVID-19 vaccines are no exception. We present a case of cutaneous leukocytoclastic vasculitis occurring 17 days after inoculation with adenoviral vector vaccine (Ad26.COV2. Read More

Curr Rheumatol Rev 2022 Jun 23. Epub 2022 Jun 23.

Internal Medicine Department, Amita Health St Joseph Hospital, Chicago, Illinois, USA.

Background IgA vasculitis is the most common form of systemic vasculitis in children but can occur in adults. Inciting antigens include infections, drugs, foods, insect bites, and immunizations. Antibiotics and tumor necrosis factor (TNF) alpha inhibitors are the most common class of drugs that cause IgA vasculitis. Read More

JAAD Int 2022 Sep 13;8:71-78. Epub 2022 Jun 13.

Division of Dermatology, University of Arizona, Tucson, Arizona.

Background: IgA vasculitis in adults has not been thoroughly studied. This has left a practice gap related to the management and follow-up of a population that is at an increased risk of comorbidities and potentially poor outcomes. For this reason, it is important to synthesize evidence from the current literature because this can help direct the movement for more robust studies to clarify best practice recommendations. Read More

Rheumatol Int 2022 Jun 13. Epub 2022 Jun 13.

Rheumatology Unit, Hospital Universitario de La Princesa, IIS-Princesa, Diego de León 62, 28006, Madrid, Spain.

COVID-19 has been related to several autoimmune diseases, triggering the appearance of autoantibodies and endothelial dysfunction. Current evidence has drawn attention to vasculitis-like phenomena and leukocytoclastic vasculitis in some COVID-19 patients. Moreover, it has been hypothesized that COVID-19 could induce flares of preexisting autoimmune disorders. Read More

J Emerg Med 2021 Oct 23. Epub 2021 Oct 23.

Harvard Medical School, Boston, Massachusetts; Brigham and Women's Hospital, Boston, Massachusetts.

Background: Although vaccination against coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been proven generally safe, rare but potentially serious adverse reactions do occur. Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis that has been associated with other immunizations, but, to our knowledge, has not been previously reported in association with vaccines directed against SARS-CoV-2.

Case Report: We report the case of a 22-year-old man with no known past medical history who presented to the Emergency Department with 2 days of migratory arthritis in his ankles and palpable purpura on his bilateral lower extremities, occurring 10 days after receiving the Johnson & Johnson SARS-CoV-2 vaccine. Read More

Front Med (Lausanne) 2022 18;9:879996. Epub 2022 May 18.

Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Gastrointestinal symptoms are common among COVID-19 patients. Although gastrointestinal involvements are mostly benign, they rarely indicate a severe pathology like intestinal ischemia. The present case series describes 21 patients with bowel ischemia, necrosis, or perforation. Read More

Clin Rheumatol 2022 Jun 2. Epub 2022 Jun 2.

Department of Dermatology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Amiodarone can be used in a variety of arrhythmias. Given its widespread use, the probability of clinicians encountering its cutaneous adverse effects is high. A few cases of amiodarone-induced cutaneous vasculitis were reported in the literature, probably because it is underdiagnosed in clinical practice. Read More

Dermatol Pract Concept 2022 May 1;12(2):e2022077. Epub 2022 Apr 1.

Dermatology and Venereology, Private Clinic, Ankara, Turkey.

Ann Med Surg (Lond) 2022 May 20;77:103650. Epub 2022 Apr 20.

Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Henoch-Schonlein purpura (HSP) in the elderly is very rare, so this case report was conducted to improve the diagnosis and management of HSP.

Case Presentation: A 65-year-old Indonesian male with severe complications of HSP had been reported. In addition to the patient's history, physical examination, laboratory and radiological findings, he performed a left sole anterior biopsy that showed interstitial infiltrate of main neutrophils, and faint granular deposits of IgA and C3 seen within the superficial vessels. Read More

Int J Dermatol 2022 May 22. Epub 2022 May 22.

Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises a group of small vessel vasculitides grouped by commonalities of clinical manifestations and ANCA testing. Skin findings are not uncommon, although there is considerable overlap and many times nonspecificity. In general, patients with skin findings tend to have more significant systemic illness, and skin lesions most often develop simultaneously or following onset of systemic symptoms. Read More

Indian J Dermatol Venereol Leprol 2022 May 4:1-3. Epub 2022 May 4.

Department of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India.

J Int Med Res 2022 May;50(5):3000605221097768

Department of Internal Medicine, King Abdullah Medical City, Makkah, Kingdom of Saudi Arabia.

Leukocytoclastic vasculitis (hypersensitivity vasculitis) is defined as small blood vessel inflammation with skin or other systemic manifestations due to infections, drugs, or neoplastic disease. This clinical case report highlights an association between ceftriaxone and leukocytoclastic vasculitis in a 49-year-old female patient with a history of penicillin allergy, on mirtazapine for anxiety disorder. Articles concerning antibiotic-induced leukocytoclastic vasculitis are also reviewed. Read More

Ther Umsch 2022 Jun;79(5):238-246

Servizio di Dermatologia EOC, Ospedale San Giovanni, Bellinzona.

Cutaneous Vasculitides - Clinical Manifestations, Diagnosis, and Aetiology Vasculitides are a heterogeneous group of diseases that are classified differently, for example according to the size of the affected vessel or according to primary and secondary causes. The skin is most frequently affected; it can be involved both as single organ vasculitis and in the context of systemic forms. The combination of skin lesions, their anatomical location and information on the time course provide clues for a differential diagnosis. Read More

Oncology (Williston Park) 2022 05;36(5):316-320

A Mexican woman, aged 60 years, presented with fevers and abdominal pain. She had initially presented to an outside emergency department with weakness, malaise, nausea, vomiting, tachycardia to 110s, and fever to 102 °F. Her medical history was relevant for hypertension, prediabetes, and tobacco use (4-5 cigarettes/day for 12 years). Read More

Int J Dermatol 2022 May 16. Epub 2022 May 16.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: ANCA-associated vasculitis (AAV) may present a wide array of dermatological manifestations. Patients may remain ANCA negative, rendering diagnosis challenging for dermatologists if they depend heavily on ANCA testing to either confirm or rule out AAV.

Objective: To compare clinical and histopathological features of AAV patients with skin lesions who are ANCA positive versus those who are ANCA negative. Read More

Clin Rev Allergy Immunol 2022 May 12. Epub 2022 May 12.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel leukocytoclastic vasculitis. This condition is skin-limited, mainly affects infants up to 2 years of age and spontaneously remits. It has been suggested that an infection or a vaccine precede (by ≤ 14 days) this vasculitis. Read More

Cureus 2022 Apr 9;14(4):e23987. Epub 2022 Apr 9.

Family Medicine, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Elmira, USA.

Immunoglobulin A (IgA) vasculitis is a small blood vessel vasculitis that is mediated by immune complex deposition. While it is the most common cause of childhood vasculitis, the disease is uncommon in adults with variable clinical manifestations. A 65-year-old female presented with a diffuse erythematous, pruritic, painful rash across her legs, back, and arms of 12 days' duration. Read More

Mod Rheumatol 2022 May 10. Epub 2022 May 10.

Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Pathological findings are important in the diagnosis of vasculitis. However, due to the rarity of the disease, standard textbooks usually devote only a few pages to this topic, and this makes it difficult for clinicians not specializing in vasculitis to fully understand the pathological findings in vasculitis. To address the paucity of information, we present representative pathological findings in vasculitis classified in the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides (CHCC2012). Read More

Cureus 2022 Mar 30;14(3):e23649. Epub 2022 Mar 30.

Internal Medicine, Michigan State University, Lansing, USA.

A 50-year-old male presented with worsening bilateral lower extremities swelling for a month, associated with a purpuric rash over bilateral upper and lower extremities, joint pain over bilateral hands and ankles, and intermittent generalized abdominal pain. Physical examination was notable for pitting edema in bilateral lower extremities and palpable, non-blanching purpuric rashes and crusts, joint tenderness over bilateral hands/wrists/ankles, and mild generalized abdominal tenderness. Laboratory tests were remarkable for sub-nephrotic range proteinuria and microscopic hematuria. Read More

Am J Dermatopathol 2022 Jul 4;44(7):523-525. Epub 2022 May 4.

Department of Dermatology, Oregon Health and Science University, Portland, OR.

Abstract: Janus kinase (JAK) inhibitors are being prescribed with increasing regularity in dermatology. We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. Read More

CMAJ 2022 May;194(17):E612

Department of Dermatology (Hung, Chen), Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Drug Hypersensitivity Clinical and Research Center (Hung, Chen), Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine (Hung, Chen), Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Immunology (Chen), College of Medicine, National Taiwan University, Taipei City, Taiwan

Semergen 2022 Feb 18. Epub 2022 Feb 18.

Servicio de Medicina Interna, Hospital clínico Universitario de Valladolid, Valladolid, España.

BMJ Case Rep 2022 Apr 22;15(4). Epub 2022 Apr 22.

Department of Dermatology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Granulocyte colony-stimulating factor (G-CSF) administration is associated with a diverse range of cutaneous sequelae. Serious dermatological side effects of G-CSF include the development of Sweet's syndrome and exacerbations of pre-existing inflammatory disorders such as psoriasis. Here, we describe a report of acute leucocytoclastic vasculitis caused by G-CSF therapy associated with anti-Ro and anti-La antibodies in a patient with multiple myeloma. Read More

Front Med (Lausanne) 2022 28;9:819320. Epub 2022 Mar 28.

Nephrology and Dialysis Unit (The European Rare Kidney Disease Reference Network, The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases, and the European Reference Network That Aims at Improving the Care of Patients With Rare Immunological Disorders), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hub Hospital, Turin, Italy.

In the countries where HCV infection is still endemic, about 90% of subjects with mixed cryoglobulinemia had previously been infected with HCV and about 80% are RNA positive. Remarkable results in severe HCV-related cryoglobulinemic vasculitis have been obtained with Rituximab. Details of the clinical characteristics and effective treatment of non HCV-related cryogloulinemic syndromes are presently lacking. Read More

Georgian Med News 2022 Mar(324):134-139

Städtisches Klinikum Dresden, 1Department of Dermatology and Allergology; Germany Städtisches Klinikum Dresden, 1Department of Dermatology and Allergology; Germany.

Vaccination has been the most powerful tool to fight the COVID-19 pandemic while the specific treatment options in clinical practice have been under review for approval and authorization by regulatory bodies. After registration of different vaccines, it is important to ensure a post-marketing surveillance to identify potential risks not observed in controlled trials. Authors report on the case of an 80-year-old male patient who developed severe leukocytoclastic vasculitis of skin and oral mucous membrane after receiving the second dose of COVID-19 mRNA vaccine. Read More

J Allergy Clin Immunol 2022 Apr;149(4):1137-1149

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Urticarial vasculitis (UV) is a rare cutaneous vasculitis of small vessels characterized by recurrent episodes of wheal-like lesions that tend to last more than 24 hours, healing with a residual ecchymotic postinflammatory hyperpigmentation. The histopathologic pattern of UV is that of leukocytoclastic vasculitis, consisting of fibrinoid necrosis of dermal vessels' walls and neutrophil-rich perivascular inflammatory infiltrates. Although its etiopahogenesis remains still undefined, UV is now regarded as an immune complex-driven disease with activation of the complement cascade, leading to exaggerated production of anaphylatoxins that are responsible for neutrophil recruitment and activation. Read More

Int J Dermatol 2022 Apr 5. Epub 2022 Apr 5.

Department of Dermatology, University of Virginia, Charlottesville, VA, USA.

J Cutan Pathol 2022 Mar 30. Epub 2022 Mar 30.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Cutaneous leukocytoclastic vasculitis (LCV) has been reported as a rare form of cutaneous reaction to different SARS-Cov-2 vaccines. Herein, we present the first case of cutaneous LCV following BBIBP-CorV (Sinopharm) vaccine that occurred in a female patient with no prior comorbidities. A literature review about similar cases following different COVID-19 vaccines is discussed. Read More

JAAD Case Rep 2022 Apr 14;22:89-92. Epub 2022 Feb 14.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.