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J Investig Allergol Clin Immunol 2018 Dec;28(6):417-418

Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina y Especialidades Médicas; Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Int J Low Extrem Wounds 2018 Dec 3:1534734618804982. Epub 2018 Dec 3.

1 Women's College Hospital, Toronto, Ontario, Canada.

Cutaneous and other vasculitides are specific inflammations of the blood vessel wall that can take place in any organ system of the body including the skin. Vasculitis has been traditionally divided according to the size of the vessel involved (small, medium, and large). Vasculitis is more of a reaction pattern rather than a specific disease entity. Read More

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

Vancomycin (VCM) has been reported to elicit adverse cutaneous drug reactions. However, VCM-associated purpuric drug eruption has not been reported yet, except leukocytoclastic vasculitis. A 16-year-old Japanese girl was admitted with a respiratory infection. Read More

Curr Rheumatol Rep 2018 Nov 17;20(12):87. Epub 2018 Nov 17.

LSU Health Science Center, New Orleans, LA, USA.

Purpose Of Review: Autoinflammatory diseases (AIDs) constitute several disorders that share similar characteristics, clinical features, disease course, and prognosis. They are characterized by the presence of recurrent episodes of unprovoked inflammation due to dysregulated innate immune system in the absence of autoantibodies or infections. AIDs include periodic fever syndromes and other less commonly growing list of syndromes. Read More

Endocr Metab Immune Disord Drug Targets 2018 Nov 6. Epub 2018 Nov 6.

Microbiology and Virology Unit, Policlinico University Hospital of Bari. Italy.

Background And Objective: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis that can be limited to the skin but may also affect other organs. Often, its cause is unknown. LCV has previously been reported to occur with the reactivation of human herpesvirus 6 (HHV-6). Read More

J Med Case Rep 2018 Oct 31;12(1):320. Epub 2018 Oct 31.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.

Background: Multiple myeloma is a very heterogeneous disease comprising a number of genetic entities that differ from each other in their evolution, mode of presentation, response to therapy, and prognosis. Due to its more chronic nature and cumulative toxicities that patients develop from multiple lines of treatments, a number of symptoms are associated with multiple myeloma. However, the mechanisms responsible for the relationship between these symptoms and multiple myeloma currently remain unclear. Read More

Lupus 2018 Dec 30;27(14):2220-2227. Epub 2018 Oct 30.

1 Department of Dermatology, Kansai Medical University, Hirakata, Japan.

Background: Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a commonly occurring condition related to systemic autoimmune disease. It is characterized histopathologically by a distinct pattern of granulomatous inflammation in the presence or absence of leukocytoclastic vasculitis. The properties of granulomatous cells in PNGD are still uncertain. Read More

Cutis 2018 Sep;102(3):169;170;175;176

Department of Dermatology, Vanderbilt University, Nashville, Tennessee, USA.

Reports of levamisole-induced vasculopathy (LIV) secondary to use of levamisole-contaminated cocaine largely have been limited to the skin. We report the case of a 35-year-old woman with painful purpuric lesions affecting the cheeks, nose, ears, arms, and legs of several days' duration. She recently had used crack cocaine. Read More

Rev Assoc Med Bras (1992) 2018 Jul;64(7):590-594

Internal Medicine Department - III, District Hospital of Santarem, Portugal.

The authors report a case of a 69-year-old man with idiopathic leukocytoclastic cutaneous vasculitis. For three years, the lesions recurred with progressive worsening and were associated with systemic manifestations of low-grade fever, weight loss and raised inflammatory markers. The patient latter presented a 6th cranial nerve involvement, raising the concern of a possible systemic vasculitis, which was latter evidenced by the development of deep vein thrombosis and angina pectoris. Read More

J Cutan Pathol 2018 Oct 25. Epub 2018 Oct 25.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation which diagnosis can be challenging. Herein we want to describe the clinicopathological spectrum of findings in five cases of EED.

Methods: We retrospectively analyzed five cases in a single institution collected over a period of 27 years. Read More

J Allergy Clin Immunol 2018 Sep 27. Epub 2018 Sep 27.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergie-Centrum-Charité, Berlin, Germany. Electronic address:

Urticarial vasculitis (UV) is a difficult-to-treat condition characterized by long-lasting urticarial rashes and histopathologic findings of leukocytoclastic vasculitis. Treatment is dictated by the severity of skin and systemic involvement and the underlying systemic disease. This is a comprehensive systematic review of the efficacy of current UV treatment options. Read More

Int J Dermatol 2018 Dec 25;57(12):1411-1416. Epub 2018 Sep 25.

Department of Dermatology, University of Texas Medical Branch, Galveston, TX, USA.

Levamisole-contaminated cocaine toxicity is a serious emerging public health concern, and providers should be aware of its presentation and management. Most cases of levamisole-induced vasculitis/vasculopathy (LIV) are associated with high antineutrophil cytoplasmic antibodies (ANCA). We describe a unique case of a cocaine user who presented with an acute purpuric eruption and negative ANCA laboratory findings. Read More

J Pediatr Endocrinol Metab 2018 Oct;31(10):1165-1168

Ghent University, Department of Pediatrics and Medical Genetics, Ghent, Belgium.

Background The association of hyperthyroidism with renal disease is very rare and the importance of timely clinical recognition cannot be overemphasized. Case presentation An 11-year-old girl presented with gastrointestinal symptoms while hypertension, edema and abdominal pain were noticed on clinical examination. Laboratory investigation revealed: hemoglobin 9. Read More

Pediatr Rheumatol Online J 2018 Sep 4;16(1):54. Epub 2018 Sep 4.

Department of Pediatric Rheumatology, Children's Hospital Colorado, 13123 East 16th Avenue, B311, Aurora, CO, 80045, USA.

Background: Henoch-Schonlein Purpura (HSP) is one of the most common vasculitides of childhood, with 10-20 cases per 100,000 children. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in small vessel walls. HSP is characterized by palpable purpura plus IgA deposition on biopsy, arthritis/arthralgia, renal involvement (hematuria and/or proteinuria), and/or abdominal pain. Read More

Therapie 2018 Jul 24. Epub 2018 Jul 24.

Département de pharmacologie, faculté de médecine de Sousse, université de Sousse, avenue Md Karoui, 4002 Sousse, Tunisie.

Introduction: Drug-induced vasculitis is reported in almost 10-20 % of vasculitis. Several drugs may be incriminated in their occurrence. Our study aimed to study the epidemiological, clinical, histopathological and evolutionary characteristics of drug-indced vasculitis from a series of cases and to specify the different drugs involved. Read More

Clin Case Rep 2018 Aug 4;6(8):1422-1425. Epub 2018 Jun 4.

Department of Pediatrics Niigata City General Hospital Niigata City Japan.

We present a child with bullous IgA vasculitis. Because skin biopsy showed epidermal vesicles with neutrophil infiltration and leukocytoclastic vasculitis in all layers of the dermis, with IgA deposits and tissue eosinophilia, extensive dermal infiltration of neutrophils may have led to both blistering eruptions and tissue eosinophilia in our patient. Read More

Dermatol Online J 2018 05 15;24(5). Epub 2018 May 15.

Medstar Georgetown University Hospital, Washington, District of Columbia.

A 24-year-old man with untreated human immunodeficiency virus (HIV) infection consulted our outreach clinic owing to the development of numerous asymptomatic nodules on his palms and fingers. Histopathologic evaluation revealed leukocytoclastic vasculitis and prominent fibrosis with a neutrophilic infiltrate consistent with erythema elevatum diutinum (EED). We referred the patient for initiation of antiretroviral therapy and started him on dapsone. Read More

J Nippon Med Sch 2018 ;85(3):172-177

Department of Dermatology, Nippon Medical School.

Cogan's syndrome (CS) is defined by the combination of hearing loss, vertigo, and ocular inflammation of uncertain cause, and can be associated with variable vessel vasculitis. Vasculitic manifestations may include arteritis (affecting large, medium or small arteries), aortitis, and aortic and mitral valvulitis. Cutaneous manifestations including erythema, papules, subcutaneous nodules, and purpura sometimes occur; however, to date, only six cases have been histologically confirmed to have genuine vasculitis. Read More

Wien Klin Wochenschr 2018 09 21;130(17-18):545-556. Epub 2018 Aug 21.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

JAAD Case Rep 2018 Aug 15;4(7):684-687. Epub 2018 Aug 15.

Department of Dermatology, University of Louisville, Louisville, Kentucky.

Vasc Endovascular Surg 2018 Aug 20:1538574418794079. Epub 2018 Aug 20.

1 Department of Vascular Medicine, Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, USA.

Hypersensitivity vasculitis (HV) or leukocytoclastic vasculitis is a rare small-vessel vasculitis that may occur as a manifestation of the body's extreme allergic reaction to a drug, infection, or other foreign substance. Characterized by the presence of inflammatory neutrophils in vessel walls, HV results in inflammation and damage to blood vessels, primarily in the skin. Histologically, when neutrophils undergo leukocytoclasia and release nuclear debris into the vasculature, vascular damage manifests as palpable purpura. Read More

Clin Breast Cancer 2018 Oct 16;18(5):e755-e758. Epub 2018 Aug 16.

Medical Oncology Department, Institut de Cancérologie de l'Ouest, Centre Paul Papin, Angers, France.

Turk Pediatri Ars 2018 Jun 1;53(2):117-119. Epub 2018 Jun 1.

Department of Pediatrics, Division of Pediatric Allergy-Immunology, Dokuz Eylül University School of Medicine, İzmir, Turkey.

The diagnosis and management of pulmonary hydatid cyst disease represents an important clinical problem in countries of the world that are endemic to echinococcal infection. Atypical clinical and radiologic findings including multiple cavitary lesions in the lung and pleural effusion may lead to misdiagnosis or delay in diagnosis in these patients. We report a patient who was followed up in our hospital with rashes and, clinical and radiologic findings of necrotizing pneumonia in whom there was no response to broad spectrum antibiotherapy. Read More

Pediatr Emerg Care 2018 Aug 14. Epub 2018 Aug 14.

Department of Pediatrics, University of Connecticut School of Medicine.

Acute hemorrhagic edema of infancy is a rare leukocytoclastic vasculitis that affects infants and children aged 4 to 24 months. We report a case of a 5-month-old girl with purpuric lesions with associated hemorrhagic lacrimation and epistaxis. Read More

Am J Gastroenterol 2018 Aug;113(8):1114

Department of Gastroenterology, Centro Hospitalar Vila Nova de Gaia Espinho, Vila Nova Gaia, Portugal.

Int J Dermatol 2018 Aug 3. Epub 2018 Aug 3.

The Kimberly and Eric J. Waldman Department of Dermatology and Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Erythema elevatum diutinum (EED) is a rare cutaneous leukocytoclastic vasculitis thought to be related to increased levels of circulating antibodies. It has been shown to be associated with HIV infection, tuberculosis, as well as various autoimmune diseases. A retrospective review of all cases of EED indexed in PubMed between 1990 and 2014 was performed. Read More

Pediatr Rev 2018 Aug;39(8):418-420

Department of Pediatrics, Cohen Children's Medical Center at Northwell Health, New Hyde Park, NY.

An Bras Dermatol 2018 Jul-Aug;93(4):614-615

Service of Dermatology, Hospital Guilherme Álvaro, Centro Universitário Lusíada, Santos (SP), Brazil.

Ann Pharmacother 2018 Dec 1;52(12):1263-1264. Epub 2018 Aug 1.

Cutis 2018 Jun;101(6):462-465

Ohio State University Medical Center, Columbus, USA.

Erythema elevatum diutinum (EED) is a rare, chronic, cutaneous small vessel vasculitis of unclear pathogenesis. Classically, lesions present as symmetric red to purple plaques, papules, and nodules overlying joints. First-line therapy is dapsone. Read More

Klin Padiatr 2018 Sep 25;230(5):270-274. Epub 2018 Jul 25.

Kliniken St. Elisabeth, Klinik für Kinder und Jugendliche, Neuburg an der Donau.

Background: Behçet's disease is a multi-system disease with inflammatory infestations, in particular of the small and middle arteries and veins. Histologically, the disease presents with the image of leukocytoclastic vasculitis. The etiology of Behçet disease is unknown, but genetic factors are discussed of playing a role in its pathogenesis. Read More

Postepy Dermatol Alergol 2018 Jun 18;35(3):323-324. Epub 2018 Jun 18.

Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poznan, Poland.

JAAD Case Rep 2018 Jul 23;4(6):606-608. Epub 2018 Jun 23.

Division of Dermatology, Harbor-UCLA Medical Center, Torrance, California.

JAAD Case Rep 2018 Jun 7;4(5):477-479. Epub 2018 May 7.

Division of Dermatology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.

Can J Kidney Health Dis 2018 31;5:2054358118776325. Epub 2018 May 31.

Division of Nephrology, Institute of Health Policy, Management and Evaluation, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Rationale: Staphylococcus-associated glomerulonephritis (SAGN) is a rare immune complex-mediated glomerulonephritis associated with active infection. We report a case illustrating the importance of clinical history and kidney biopsy findings in establishing the correct diagnosis.

Presenting Concerns Of The Patient: We report the case of a 64-year-old man with alcohol-associated cirrhosis, type 2 diabetes mellitus, and hypertension who presented to hospital with lower back and abdominal pain, rectal bleeding, a purpuric lower extremity rash, and oliguric acute kidney injury with microscopic hematuria and nephrotic-range proteinuria. Read More

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

J Dermatol 2018 Aug 15;45(8):1009-1012. Epub 2018 May 15.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Leukocytoclastic vasculitis is often associated with immunoglobulin (Ig)A deposition on the vascular walls. IgA-associated leukocytoclastic vasculitis comprises various underlying diseases. Hematological disorders that can be minor triggers include multiple myeloma and monoclonal gammopathy of undetermined significance. Read More

Cureus 2018 Mar 14;10(3):e2323. Epub 2018 Mar 14.

Department of Dermatology, University of California, San Diego.

The influenza vaccination is recommended annually for protection against influenza infection. Adults over 65 years of age are especially vulnerable to complications from influenza infection; in addition, they constitute the largest group of influenza vaccination recipients each year. Cutaneous leukocytoclastic vasculitis involves inflammation of small vessel walls by neutrophils. Read More

BMC Pediatr 2018 05 10;18(1):157. Epub 2018 May 10.

Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1st Road, Zuoying District, Kaohsiung City, 813, Taiwan.

Background: Henoch-Schönlein purpura (HSP) is a common vasculitis in childhood characterized by purpura, arthritis, abdominal pain and renal involvement. However, bullous HSP is a rare cutaneous manifestation, and a few cases have been reported.

Case Presentation: Herein, we report a 15-year-old male with bullous HSP who presented with severe abdominal pain and hemorrhagic bullous lesions over his lower extremities. Read More

J Drugs Dermatol 2018 May;17(5):532-536

Reflex sympathetic dystrophy is a subtype of complex regional pain syndrome, a condition characterized by persistent post-injury extremity pain. Temperature and sweating changes, edema, mobility changes, and a variety of hair, nail, and skin sequelae have been described. Only 23 articles published since 1990 describe dermatologic changes in CRPS. Read More

Oncotarget 2018 Apr 13;9(28):20213-20218. Epub 2018 Apr 13.

Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan.

Anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) dramatically improve progression-free survival compared to cytotoxic agents. It is therefore important to manage patients with ALK-TKIs until drug resistance occurs. Leukocytoclastic vasculitis (LCV) is a rare complication during cancer treatment and is associated with a variety of factors. Read More

Reumatol Clin 2018 May 2. Epub 2018 May 2.

Servicio de Anatomía Patológica, Hospital Universitari Sagrat Cor, Barcelona, España.

Am J Dermatopathol 2018 Oct;40(10):767-771

Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Taiwan.

Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. Read More

Front Immunol 2018 11;9:735. Epub 2018 Apr 11.

Infection Inflammation and Rheumatology Section, Great Ormond Street Institute of Child Health, University College London, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.

Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune conditions. It is increasingly recognised that some monogenic autoinflammatory diseases cause vasculitis, although genetic causes of vasculitis are extremely rare. Read More

BMJ Case Rep 2018 Apr 21;2018. Epub 2018 Apr 21.

Department of Urology, Austin Health, Heidelberg, Victoria, Australia.

Renal cell carcinoma is historically known as the 'great masquerader' with 40% of patients experiencing a paraneoplastic syndrome. Translocation carcinoma represents one-third of renal cancer in paediatric patients but less than 3% of renal cancers in patients aged 18-45 years where the clinical course is often rapidly terminal. There are less than 10 reported cases of leucoclastic vasculitis associated with clear cell carcinoma reported in the literature and 10 case reports of translocation carcinoma in adults. Read More

Am J Dermatopathol 2018 Sep;40(9):661-666

Departments of Histopathology.

Skin is commonly affected by vasculitic process and often subjected to biopsy. Cutaneous vasculitis can be either primary or part of a systemic vasculitic process. This study was conducted to evaluate the diagnostic utility of direct immunofluorescence (DIF) in determination of etiology of cutaneous vasculitis. Read More

J Clin Rheumatol 2018 Apr 13. Epub 2018 Apr 13.

From the Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Rinsho Ketsueki 2018;59(3):269-274

Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine.

A 73-year-old man with left parotid gland swelling over 2 months was referred to our hospital in March 201X. Purpura on the lower legs had been recurrent for >20 years. Biopsy of the parotid gland demonstrated diffuse infiltration of abnormal lymphocytes that were negative for CD10 and positive for CD19, CD20, and κ-chain. Read More

Clin Lymphoma Myeloma Leuk 2018 May 19;18(5):e197-e200. Epub 2018 Mar 19.

Department of Hematology-Oncology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon. Electronic address:

Case Rep Nephrol Dial 2017 Sep-Dec;7(3):144-153. Epub 2017 Nov 27.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

Systemic urticaria in a 64-year-old woman was diagnosed as leukocytoclastic vasculitis by a punch biopsy of the skin. Her physical findings improved after prescription of prednisolone at a dose of 20 mg/day, but the skin rash relapsed with renal dysfunction, proteinuria, and hematuria when the dose of prednisolone was reduced over a period of 9 months to 1 mg/day. She was admitted to our institute for further examination, when urinary protein and plasma creatinine levels were 0. Read More