320,739 results match your criteria Leukemias


Towards a more precise therapy in cancer: Exploring epigenetic complexity.

Curr Opin Chem Biol 2020 May 29;57:41-49. Epub 2020 May 29.

Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain; Epigenetic Therapies Group, Experimental and Clinical Hematology Program (PHEC), Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain. Electronic address:

A plethora of preclinical evidences suggests that pharmacological targeting of epigenetic dysregulation is a potent strategy to combat human diseases. Nevertheless, the implementation of epidrugs in clinical practice is very scarce and mainly limited to haematological malignancies. In this review, we discuss cutting-edge strategies to foster the chemical design, the biological rationale and the clinical trial development of epidrugs. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.04.008DOI Listing

Regulation of CD4CD25FOXP3 cells in Pediatric Acute Lymphoblastic Leukemia (ALL): Implication of cytokines and miRNAs.

Mol Immunol 2020 May 29;124:1-8. Epub 2020 May 29.

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat, Egypt. Electronic address:

Regulatory T cells (Tregs) is one of the immunosuppressive subsets of CD4 T cells characterized by transcription factor forkhead box protein P3 (FOXP3) expression which are involved in tumor development and progression. Identification of the factors that influence Treg cell function is extremely important. Our current study aimed to evaluate the frequency of Treg cells, cytokine secretion and the expression of microRNAs (miRNAs) in pediatric acute lymphoblastic leukemia (ALL) patients. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.05.002DOI Listing

Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity.

Phytochemistry 2020 May 29;176:112415. Epub 2020 May 29.

Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.

Cytotoxicity-guided fractionation of the MeOH extract of Helleborus lividus Aiton ex Curtis (Ranunculaceae) resulted in the isolation of five undescribed bufadienolide glycosides and two undescribed bufadienolides, along with three known compounds. Their structures were determined by detailed spectroscopic analysis and hydrolysis studies. The isolated compounds showed cytotoxicity against HL-60 human leukemia cells and A549 human lung adenocarcinoma cells, with IC values ranging from 2. Read More

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http://dx.doi.org/10.1016/j.phytochem.2020.112415DOI Listing

A Suggested Immunohistochemical Algorithm for the Classification of T Cell Lymphomas Involving Lymph Node.

Hum Pathol 2020 May 29. Epub 2020 May 29.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

T cell lymphomas are a heterogeneous group of neoplasms derived from mature T lymphocytes. These neoplasms are uncommon and usually diagnostically challenging. The focus of this paper is to suggest an immunohistochemistry-based, practical approach to assist in the diagnosis of nodal T-cell lymphomas. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.05.006DOI Listing

Competing Endogenous RNA Regulation in Hematologic Malignancies.

Clin Chim Acta 2020 May 29. Epub 2020 May 29.

Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016. Electronic address:

The clinical application of cytogenetic analysis and molecular-targeted drugs has dramatically improved the prognosis for many patients with hematologic malignancy, especially for those with chronic myeloid leukemia (CML) and acute promyelocytic leukemia (APL). Nevertheless, the treatment of hematologic malignancies is still faced with problems, such as disease recurrence and drug resistance, so further exploring the underlying molecular mechanism is urgent. With the discovery of different RNA species, the mechanism of RNA-RNA interaction has caught more and more attention. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.045DOI Listing

Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.

Cytometry B Clin Cytom 2020 Jun 1. Epub 2020 Jun 1.

M. Tettamanti Research Center , University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy.

Background: The PI3K/Akt/mTOR (PI3K) signaling pathway has a crucial role in T-cell acute lymphoblastic leukemias (T-ALLs). Although loss-of-function of phosphatase and tensin homolog (PTEN) is a common event in pediatric T-ALLs, the exact role of this tumor suppressor in T-ALL development has yet to be defined.

Methods: Here, we report an optimized cytometric method for accurate proteomic profiling of T-ALL leukemic blasts at single-cell level. Read More

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http://dx.doi.org/10.1002/cyto.b.21882DOI Listing

The Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), a Versatile Functional Species: A Review.

Int J Med Mushrooms 2020 ;22(3):245-255

School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, P.R. China.

Coprinus comatus, an edible and medicinal mushroom, not only tastes delicious, but also has various pharmacological activities. Recently, it has been reported that researchers have extracted more and more active ingredients, including polysaccharides, comatin, active protein complexes, and phenols from fruit bodies, mycelium, or fermentation liquor of C. comatus and studied their corresponding functions. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2020033988DOI Listing
January 2020

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody.

J Vis Exp 2020 May 16(159). Epub 2020 May 16.

Laboratory of Novel Biologics, University of Virginia School of Medicine; Department of Biochemistry and Molecular Genetics, UVA Cancer Center, University of Virginia School of Medicine;

Monoclonal antibodies are high affinity multifunctional drugs that work by variable independent mechanisms to eliminate cancer cells. Over the last few decades, the field of antibody-drug conjugates, bispecific antibodies, chimeric antigen receptors (CAR) and cancer immunotherapy has emerged as the most promising area of basic and therapeutic investigations. With numerous successful human trials targeting immune checkpoint receptors and CAR-T cells in leukemia and melanoma at a breakthrough pace, it is highly exciting times for oncologic therapeutics derived from variations of antibody engineering. Read More

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http://dx.doi.org/10.3791/60727DOI Listing

The depot GnRH agonist protocol improves the live birth rate per fresh embryo transfer cycle, but not the cumulative live birth rate in normal responders: a randomized controlled trial and molecular mechanism study.

Hum Reprod 2020 Jun 1. Epub 2020 Jun 1.

Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People's Republic of China.

Study Question: Do cumulative live birth rates (CLBRs) after one complete ART cycle differ between the three commonly used controlled ovarian stimulation (COS) protocols (GnRH antagonist, depot GnRHa (GnRH agonist) and long GnRHa) in normal responders undergoing IVF/ICSI?

Summary Answer: There were similar CLBRs between the GnRH antagonist, depot GnRHa and long GnRHa protocols.

What Is Known Already: There is no consensus on which COS protocol is the most optimal in women with normal ovarian response. The CLBR provides the final success rate after one complete ART cycle, including the fresh and all subsequent frozen-thawed embryo transfer (ET) cycles. Read More

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http://dx.doi.org/10.1093/humrep/deaa086DOI Listing

Vena cava superior syndrome in the children with mediastinal tumors: Single-center experience.

North Clin Istanb 2020 9;7(3):255-259. Epub 2020 Apr 9.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Objective: Vena cava superior syndrome comprises various symptoms of compression of vena cava superior. The results of increased venous pressure in the upper body may cause edema of the head and neck associated with cyanosis, plethora and distended subcutaneous vessels. Vena cava superior syndrome is rare in childhood. Read More

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http://dx.doi.org/10.14744/nci.2019.46354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251265PMC

Economic analysis of oral posaconazole prophylaxis in acute myeloid leukemia during remission induction in Turkey.

North Clin Istanb 2020 8;7(3):222-225. Epub 2020 Apr 8.

Department of Hematology, Trakya University Faculty of Medicine, Edirne, Turkey.

Objective: Invasive fungal infections (IFI) are important and trending causes of mortality in patients with acute leukemia, especially during the remission induction.

Methods: In this study, 225 patients who were diagnosed with acute myeloid leukemia (AML) and undergoing intensive treatment for remission induction were enrolled in a retrospective manner.

Results: Within the whole group, which consisted of 225 patients, 90 patients received prophylactic antifungal treatment (PAT) (40%), while 135 patients did not (60%) receive. Read More

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http://dx.doi.org/10.14744/nci.2019.89896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251278PMC

Bilateral macular detachment: Choroid as a sanctuary of acute lymphoblastic leukemia.

Am J Ophthalmol Case Rep 2020 Sep 13;19:100746. Epub 2020 May 13.

Buenos Aires Macula, Buenos Aires, Argentina.

Purpose: To describe a bilateral macular detachment as the only sign of acute lymphoblastic leukemia relapse and prompt reversal with total body irradiation without ocular protection.

Observations: We present the case of a 20-year-old patient, diagnosed with a high-risk phy-negative, pre-B acute lymphoblastic leukemia (ALL), with a positive MLL gene rearrangement. After a Berlin-Frankfurt-Munster-like regimen chemotherapy protocol and a first complete remission, ALL relapse was diagnosed, so he was commenced on a FlaG-Ida protocol (fludarabine, idarubicin, granulocyte-colony stimulating factor, and high-dose cytarabine). Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251383PMC
September 2020

Clinical trials using molecular stratification of pediatric brain tumors.

Transl Pediatr 2020 Apr;9(2):144-156

Department of Pediatrics, Division of Child Neurology, Weill Cornell Medicine, New York, NY, USA.

Brain cancer is now the leading cause of cancer death in children and adolescents, surpassing leukemia. The heterogeneity and invasiveness of pediatric brain tumors have historically made them difficult to treat. Although surgical intervention and standard of care therapies such as radiation and chemotherapy have improved the outlook for those affected, results are often transient and lend themselves to tumor recurrence or resistance. Read More

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http://dx.doi.org/10.21037/tp.2020.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237976PMC

Spontaneous remission of acute myeloid leukemia with NF1 alteration.

Leuk Res Rep 2020 16;13:100204. Epub 2020 May 16.

University of Miami, Department of Medicine, Miami, FL, United States.

Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. Read More

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http://dx.doi.org/10.1016/j.lrr.2020.100204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251391PMC

Mapping Local Biospecimen Records to the OMOP Common Data Model.

AMIA Jt Summits Transl Sci Proc 2020 30;2020:422-429. Epub 2020 May 30.

Department of Healthcare Policy & Research, Weill Cornell Medicine, New York, NY.

Research to support precision medicine for leukemia patients requires integration of biospecimen and clinical data. The Observational Medical Outcomes Partnership common data model (OMOP CDM) and its Specimen table presents a potential solution. Although researchers have described progress and challenges in mapping electronic health record (EHR) data to populate the OMOP CDM, to our knowledge no studies have described populating the OMOP CDM with biospecimen data. Read More

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Establishment of a FDC-P1 Murine Cell Line with Human KIT N822K Gene Overexpression.

Acta Naturae 2020 Jan-Mar;12(1):51-55

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.

The mechanism of resistance of leukemia cells to chemotherapeutic drugs remains poorly understood. New model systems for studying the processes of malignant transformation of hematopoietic cells are needed. Based on cytokine-dependent murine acute myeloid leukemia (AML) FDC-P1 cells, we generated a new cell line with ectopic expression of the gene encoding mutant human receptor tyrosine kinase (N822K). Read More

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http://dx.doi.org/10.32607/actanaturae.10938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245965PMC

Advances in targeted therapy for acute myeloid leukemia.

Biomark Res 2020 20;8:17. Epub 2020 May 20.

4The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008 China.

Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than half of a century. Although much progress has been made toward improving treatment related mortality rate in the past few decades, long term overall survival has stagnated. Read More

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http://dx.doi.org/10.1186/s40364-020-00196-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238648PMC

Diagnostic challenge of aleukemic leukemia cutis preceding acute myelogenous leukemia: A case report.

SAGE Open Med Case Rep 2020 6;8:2050313X20919638. Epub 2020 May 6.

Division of Dermatology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Aleukemic leukemia cutis is a rare condition in which malignant white cells invade the skin before they appear in the peripheral blood or bone marrow. It is often associated with a poor prognosis. The condition presents a diagnostic challenge as its manifestations are quite variable terms of lesion type. Read More

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http://dx.doi.org/10.1177/2050313X20919638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233898PMC

Management of atypical chronic lymphocytic leukemia presenting with extreme leukocytosis.

Clin Case Rep 2020 May 5;8(5):877-882. Epub 2020 Mar 5.

Division of Hematology/Oncology Department of Internal Medicine NYU Long Island School of Medicine NYU Winthrop Hospital Mineola NY USA.

Atypical chronic lymphocytic lymphoma (CLL) with CCND1 translocation is poorly described, particularly in the era of modern inhibitors of the B-cell receptor pathway. We present a patient with atypical CLL who had a significant response to ibrutinib, highlighting the effectiveness of this agent in higher risk CLL subgroups. Read More

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http://dx.doi.org/10.1002/ccr3.2773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250984PMC

p210- Chronic myeloid leukemia presents with monocytosis.

Clin Case Rep 2020 May 9;8(5):840-842. Epub 2020 Mar 9.

Shandong Provincial Hospital Affiliated to Shandong University Jinan China.

Rare cases of CML present with monocytosis as well as morphologic dysplasia and harbor p210. Cytogenetic and molecular studies must be performed to confirm the diagnosis of this kind of CML. Read More

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http://dx.doi.org/10.1002/ccr3.2783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250983PMC

The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice.

Front Immunol 2020 12;11:888. Epub 2020 May 12.

Department of Oncology/Hematology, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.

Research on CAR T cells has achieved enormous progress in recent years. After the impressive results obtained in relapsed and refractory B-cell acute lymphoblastic leukemia and aggressive B-cell lymphomas, two constructs, tisagenlecleucel and axicabtagene ciloleucel, were approved by FDA. The role of CAR T cells in the treatment of B-cell disorders, however, is rapidly evolving. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235422PMC

Immune Modulation Properties of Zoledronic Acid on TcRγδ T-Lymphocytes After TcRαβ/CD19-Depleted Haploidentical Stem Cell Transplantation: An analysis on 46 Pediatric Patients Affected by Acute Leukemia.

Front Immunol 2020 12;11:699. Epub 2020 May 12.

Department of Pediatric Hematology and Oncology and of Cell and Gene Therapy, Scientific Institute for Research and Healthcare (IRCCS), Bambino Gesù Childrens' Hospital, Rome, Italy.

TcRαβ/CD19-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) represents a promising new platform for children affected by acute leukemia in need of an allograft and lacking a matched donor, disease recurrence being the main cause of treatment failure. The use of zoledronic acid to enhance TcRγδ+ lymphocyte function after TcRαβ/CD19-cell depleted haplo-HSCT was tested in an open-label, feasibility, proof-of-principle study. Forty-six children affected by high-risk acute leukemia underwent haplo-HSCT after removal of TcRαβ+ and CD19+ B lymphocytes. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235359PMC

Optimal Management of Acute Lymphoblastic Leukemia (ALL) in Adult Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic.

Gulf J Oncolog 2020 May;1(33):7-18

Adult Hematology and HSCT, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

The outbreak of coronavirus disease 2019 (COVID-19) has become a public health emergency of major international concern. In December 2019, an outbreak of atypical pneumonia known as COVID-19 was identified in Wuhan, China. The newly identified zoonotic coronavirus, severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), is characterized by rapid human-to-human transmission. Read More

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Mutational landscape of patients with acute myeloid leukemia or myelodysplastic syndromes in the context of RUNX1 mutation.

Hematology 2020 Dec;25(1):211-218

Department of Hematology, The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, People's Republic of China.

RUNX1 mutations in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with distinct clinicopathologic features. However, the clinical and laboratory characteristics of the myeloid malignancies may be influenced by the presence of more concomitant mutations. The aim of this study is to provide a further understanding of mutational landscape in the context of RUNX1 mutation in AML/MDS. Read More

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http://dx.doi.org/10.1080/16078454.2020.1765561DOI Listing
December 2020

Anaphylaxis related to disinfection with chlorhexidine in a teenager treated for cancer.

J Oncol Pharm Pract 2020 May 31:1078155220925531. Epub 2020 May 31.

Division of Pediatric Haemato-Oncology and Stem Cell Transplantation, Department of Pediatrics, Ghent University Hospital, Ghent, Belgium.

Introduction: Literature shows upcoming allergy to chlorhexidine due to the widespread use of the disinfectant within and outside surgical settings. Only a few case reports have been published regarding the use of topical chlorhexidine disinfectant outside surgery and only a minority of these within the pediatric population.

Case Report: We present a case-report of a teenager, treated for acute lymphoblastic leukemia who developed an anaphylactic shock after repeated chlorhexidine use for skin disinfection at the insertion of a central venous catheter during his chemotherapy treatment. Read More

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http://dx.doi.org/10.1177/1078155220925531DOI Listing

A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.

Leuk Lymphoma 2020 May 30:1-9. Epub 2020 May 30.

Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.

High-dose cytarabine (HiDAC) consolidation for acute myeloid leukemia (AML) induces transient profound myelosuppression and potential morbidity/mortality. PrE0901 was a phase I multi-center trial evaluating the safety/toxicity of eltrombopag in AML patients receiving HiDAC consolidation. We used a standard 3 + 3 design employing a unique dose-escalation/de-escalation strategy. Read More

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http://dx.doi.org/10.1080/10428194.2020.1762878DOI Listing

The prognostic value of CD2, CD4, and HLA-DR expression and FLT3-ITD mutation in adult acute promyelocytic leukemia.

Leuk Lymphoma 2020 May 30:1-6. Epub 2020 May 30.

Zhengzhou University, Zhengzhou, China.

In order to explore the prognostic value of CD2, CD4, and human leucocyte antigen-DR (HLA-DR) expression and Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation in leukemia cells in the bone marrow of patients with acute promyelocytic leukemia (APL), we retrospectively collected and analyzed the immunophenotype, molecular features and clinical characteristics of 219 newly diagnosed adult patients with APL in Henan Provincial People's Hospital from January 2010 to December 2019. It turned out that the relapse rates of patients with CD2, CD4, or HLA-DR expression and the early mortality rates of patients with CD2 expression, HLA-DR expression, or FLT3-ITD mutation were higher than those of their counterparts. Moreover, reduced overall survival was found for patients who showed CD2 expression, HLA-DR expression or FLT3-ITD mutation. Read More

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http://dx.doi.org/10.1080/10428194.2020.1768386DOI Listing

Leukostasis retinopathy with leukemic infiltrates as onset manifestation of chronic myeloid leukemia: a case report.

Eur J Ophthalmol 2020 May 31:1120672120930679. Epub 2020 May 31.

Eye Clinic, Neuromuscular and Sense Organs Department, Careggi University Hospital, University of Florence, Florence, Italy.

Purpose: To describe a case of retinopathy as onset manifestation of chronic myeloid leukemia (CML), successfully treated with leukapheresis and medical therapy.

Methods: A 28-year-old male patient presented complaining painless acute visual impairment in his right eye (RE). He reported moderate asthenia and episodes of night sweats during the previous month. Read More

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http://dx.doi.org/10.1177/1120672120930679DOI Listing

Association of GGH Promoter Methylation Levels with Methotrexate Concentrations in Chinese Children with Acute Lymphoblastic Leukemia.

Pharmacotherapy 2020 Jun 1. Epub 2020 Jun 1.

Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Background: Gamma-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study aims to explore the methylation status of the GGH promoter in peripheral blood and its association with MTX levels and toxicities in Chinese children with ALL.

Methods: Serum MTX concentrations were determined by fluorescence polarization immunoassay. Read More

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http://dx.doi.org/10.1002/phar.2430DOI Listing

Association between oral health-related quality of life and periodontal status in patients with leukemia.

Int Dent J 2020 May 31. Epub 2020 May 31.

Periodontics Unit, Department of Stomatology, Dental School, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

Objective: The aim was to evaluate the association between oral health-related quality of life (OHRQol) and periodontal status in patients with leukemia.

Methods: A total of 55 patients with leukemia (42.09 ± 16. Read More

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http://dx.doi.org/10.1111/idj.12576DOI Listing

Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications.

Curr Oncol Rep 2020 Jun 1;22(6):61. Epub 2020 Jun 1.

Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.

Purpose Of Review: The field of acute myeloid leukemia (AML) has been revolutionized in recent years by the advent of high-throughput techniques, such as next-generation sequencing. In this review, we will discuss some of the recently identified mutations that have defined a new molecular landscape in this disease, as well as their prognostic, predictive, and therapeutic implications.

Recent Findings: Recent studies have shown how many cases of AML evolve from a premalignant period of latency characterized by the accumulation of several mutations and the emergence of one or multiple dominant clones. Read More

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http://dx.doi.org/10.1007/s11912-020-00918-7DOI Listing

Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma.

Leukemia 2020 Jun 1. Epub 2020 Jun 1.

Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA), Navarra, Spain.

Multiple myeloma (MM) patients undergo repetitive bone marrow (BM) aspirates for genetic characterization. Circulating tumor cells (CTCs) are detectable in peripheral blood (PB) of virtually all MM cases and are prognostic, but their applicability for noninvasive screening has been poorly investigated. Here, we used next-generation flow (NGF) cytometry to isolate matched CTCs and BM tumor cells from 53 patients and compared their genetic profile. Read More

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http://dx.doi.org/10.1038/s41375-020-0883-0DOI Listing

Multiple myeloma and COVID-19.

Leukemia 2020 Jun 1. Epub 2020 Jun 1.

Division of Hematology/Oncology, Medical College of Wisconsin, Wauwatosa, WI, USA.

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http://dx.doi.org/10.1038/s41375-020-0879-9DOI Listing

Detection and genotyping of bovine leukemia virus (BLV) in Vietnamese cattle.

J Vet Med Sci 2020 Jun 1. Epub 2020 Jun 1.

Division of Infection Control and Disease Prevention, Department of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo.

Bovine leukemia virus (BLV) belongs to the genus, Deltaretrovirus of the family, Retroviridae and it is the causative agent of enzootic bovine leukosis. The prevalence of BLV in three provinces in the Red River Delta Region in the North of Vietnam, Hanoi, Vinhphuc and Bacninh was studied from April 2017 to June 2018. A total of 275 blood samples collected from cattle were used for serum isolation and DNA extraction. Read More

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http://dx.doi.org/10.1292/jvms.20-0094DOI Listing

Drug resistance in cancer therapy and the possible role of epigenetics.

Authors:
Takeshi Asano

J Nippon Med Sch 2020 May 30. Epub 2020 May 30.

Department of Pediatrics, Nippon Medical School.

Effective leukemia treatment is seriously hampered by drug resistance. The possible roles of epigenetic mechanisms have recently been considered in cancer drug resistance. With conventional anti-cancer drugs, including alkylating drugs, anti-metabolite drugs, topoisomerase inhibitors, and microtubule inhibitors, which have been available for half a century, the drug resistance often occurs due to decreased expression of target enzymes, with increased expression of drug export pumps. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2020_87-508DOI Listing

Inclusion of molecular monitoring (BCR-ABL1) in the treatment of chronic myeloid leukemia in the Brazilian Public Health System (SUS): an urgent need for treatment management.

Hematol Transfus Cell Ther 2020 May 25. Epub 2020 May 25.

Departamento de Hematologia, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

Introduction: Chronic Myeloid Leukemia (CML) is a myeloproliferative disease that affects mainly adults between 50 and 55 years. In Brazil, information from the Sistema Único de Saúde (SUS) Outpatient Information System indicates that 12,531 patients had the Autorização de Procedimento Ambulatorial (APAC) approved for the CML treatment in 2017. Disease monitoring through molecular response evaluation is critical to the care of CML patients. Read More

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http://dx.doi.org/10.1016/j.htct.2020.02.002DOI Listing

Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-d-glucan.

Carbohydr Polym 2020 Jul 23;240:116329. Epub 2020 Apr 23.

Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. Electronic address:

Acute myeloid leukemia (AML) is a difficult therapeutic hematological tumor. It is urgent to find a non-toxic natural drug to treat AML. Herein, the selenium nanoparticles (SeNPs) embedded in nanotubes consisted of triple helix β-(1, 3)-d-glucan (BFP) from the black fungus that were wrapped to form stable inclusion complex BFP-Se, which was self-assembled and exhibited high stability in water. Read More

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http://dx.doi.org/10.1016/j.carbpol.2020.116329DOI Listing

Auditory attention late effects in pediatric acute lymphoblastic leukemia.

Child Neuropsychol 2020 Jun 1:1-16. Epub 2020 Jun 1.

Department of Psychiatry, University of Texas Southwestern Medical Center , Dallas, TX, USA.

This study sought to characterize auditory attention functioning among pediatric Acute Lymphoblastic Leukemia (ALL) survivors treated on a chemotherapy-only protocol, given previous literature suggesting late impact on sustained visual attention. We hypothesized similar deficits would be observed in auditory attention relative to previous literature indicating weakness with aspect of visual attention in this population. Survivors 107, 53 females, = 12. Read More

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http://dx.doi.org/10.1080/09297049.2020.1772738DOI Listing

Benzene exposure-response and risk of lymphoid neoplasms in Chinese workers: A multicenter case-cohort study.

Am J Ind Med 2020 May 31. Epub 2020 May 31.

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland.

Background: While international agreement supports a causal relationship of benzene exposure with acute myeloid leukemia, there is debate about benzene and lymphoid neoplasm risks.

Methods: In a case-cohort study with follow-up of 110 631 Chinese workers during 1972-1999, we evaluated benzene exposure-response for non-Hodgkin lymphoma (NHL), lymphoid leukemias (LL), acute lymphocytic leukemia (ALL), and total lymphoid neoplasms (LN). We estimated benzene exposures using state-of-the-art hierarchical modeling of occupational factors calibrated with historical routine measurements and evaluated cumulative exposure-response using Cox regression. Read More

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http://dx.doi.org/10.1002/ajim.23142DOI Listing

Differences in PD-1 expression on CD8+ T-cells in chronic myeloid leukemia patients according to disease phase and TKI medication.

Cancer Immunol Immunother 2020 May 30. Epub 2020 May 30.

Department of Hematology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Malignant cells can increase in number using immune escape mechanisms such as immune checkpoints. In this study, we evaluated the expression of an immune checkpoint programmed death 1 (PD-1) on T-cell subsets in chronic myeloid leukemia (CML). We obtained bone marrow aspirate samples from CML patients and from individuals without evidence of hematologic malignancies (controls). Read More

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http://dx.doi.org/10.1007/s00262-020-02617-5DOI Listing

Renin angiotensin system inhibitors reduce the incidence of arterial thrombotic events in patients with hypertension and chronic myeloid leukemia treated with second- or third-generation tyrosine kinase inhibitors.

Ann Hematol 2020 May 30. Epub 2020 May 30.

Department of Medical Sciences and Public Health, University of Cagliari, Hematology Businco Hospital, Cagliari, Italy.

Hypertension is a commonly reported comorbidity in patients diagnosed with chronic myeloid leukemia (CML), and its management represents a challenge in patients treated with 2nd- or 3rd-generation tyrosine kinase inhibitors (TKIs), considering their additional cardiovascular (CV) toxicity. The renin angiotensin system (RAS) contributes to hypertension genesis and plays an important role in atherosclerosis development, proliferation, and differentiation of myeloid hematopoietic cells. We analyzed a cohort of 192 patients with hypertension at CML diagnosis, who were treated with 2nd- or 3rd-generation TKIs, and evaluated the efficacy of RAS inhibitors (angiotensin-converting enzyme inhibitors (ACEi) and angiotensin-II receptor blockers (ARBs)) in the prevention of arterial occlusive events (AOEs), as compared with other drug classes. Read More

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http://dx.doi.org/10.1007/s00277-020-04102-6DOI Listing

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Leukemia 2020 May 30. Epub 2020 May 30.

Department of Pediatrics and Adolescent Medicine, Ulm University Medical Centre, D-89075, Ulm, Germany.

The bone marrow is home to well-balanced normal hematopoiesis, but also the stage of leukemia's crime. Marrow adipose tissue (MAT) is a unique and versatile component of the bone marrow niche. While the importance of MAT for bone health has long been recognized, its complex role in hematopoiesis has only recently gained attention. Read More

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http://dx.doi.org/10.1038/s41375-020-0886-xDOI Listing

Tocilizumab, but not dexamethasone, prevents CRS without affecting antitumor activity of bispecific antibodies.

J Immunother Cancer 2020 May;8(1)

Department of Immunology, University of Tübingen Interfaculty Institute of Cell Biology, Tubingen, Germany

Bispecific antibodies (bsAb) and chimeric antigen receptor (CAR) T cells allow for antibody guided recruitment of T cells against tumors. Both are successfully used for treatment of CD19 expressing leukemias, but may cause cytokine release syndrome (CRS) as a major dose-limiting side effect. For CRS prevention, steroids are recommended prior to bsAb treatment, despite their well-known lymphotoxic activity. Read More

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http://dx.doi.org/10.1136/jitc-2020-000621DOI Listing

Outcome of Childhood Acute Myeloid Leukemia With FLT3-ITD Mutation: The Experience of Children's Cancer Hospital Egypt, 2007-17.

Clin Lymphoma Myeloma Leuk 2020 Apr 21. Epub 2020 Apr 21.

Department of Pediatric Oncology, Children's Cancer Hospital Egypt, Cairo, Egypt; Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.

Introduction: The presence of FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutation in pediatric acute myeloid leukemia (AML) is associated with high rates of induction failure and worse survival. Its presence places the patient into a high-risk group. We aimed to describe the outcome of pediatric AML with FLT3-ITD mutation. Read More

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http://dx.doi.org/10.1016/j.clml.2020.04.011DOI Listing

Complexities in the diagnosis of large B-cell lymphomas, classic Hodgkin lymphomas and overlapping peripheral T-cell lymphomas simplified: An evidence-based guide.

Ann Diagn Pathol 2020 May 15;46:151534. Epub 2020 May 15.

Department of Pathology, University of California, San Francisco, CA 94143, United States of America. Electronic address:

The diagnosis of a large B-cell lymphoma and classic Hodgkin lymphoma (CHL) is often straightforward. However, in select circumstances, these simple diagnoses can be quite complex. In part, diagnostic difficulty may be due to uncertainty in the evaluation of morphologic and immunophenotypic features along a biologic continuum, or alternatively arise from uncertainty in predicting the behavior and outcomes of patients. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151534DOI Listing

Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition PIM-1 kinase activity.

Arch Biochem Biophys 2020 May 27:108413. Epub 2020 May 27.

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Cancer Research Institute, Seoul National University, Seoul, 03080, South Korea. Electronic address:

The proviral integration site for Moloney murine leukemia virus (PIM) family of serine/threonine-specific kinases consist of three isoforms, that regulate proliferation, apoptosis, metabolism, invasion and metastasis of cancer cells. Among these, abnormally elevated kinase activity of PIM-1 contributes to the progression of gastric cancer and responsible for poor prognosis and low survival rate in gastric cancer patients. In the present study, we found that resveratrol, one of the representative chemopreventive and anticarcinogenic phytochemical, directly binds to PIM-1 and thereby inhibits its catalytic activity in human gastric cancer SNU-601 gastric cancer cells. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108413DOI Listing

Genotypic and phenotypic characteristics of acute promyelocytic leukemia translocation variants.

Hematol Oncol Stem Cell Ther 2020 May 20. Epub 2020 May 20.

Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Acute promyelocytic leukemia (APL) is a special disease entity of acute myeloid leukemia (AML). The clinical use of all-trans retinoic acid (ATRA) has transformed APL into the most curable form of AML. The majority of APL cases are characterized by the fusion gene PML-RARA. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.05.007DOI Listing

Whole-joint magnetic resonance imaging to assess osteonecrosis in pediatric patients with acute lymphoblastic lymphoma.

Pediatr Blood Cancer 2020 May 30:e28336. Epub 2020 May 30.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: Osteonecrosis is a debilitating complication in children and adolescents with acute lymphoblastic leukemia or acute lymphoblastic lymphoma (LLy). An objective screening test to identify patients at risk for symptomatic, extensive joint involvement will help manage osteonecrosis.

Methods: We performed a prospective, longitudinal pilot study with whole-joint magnetic resonance imaging (MRI) of shoulders, elbows, hips, knees, ankles, and hindfeet to evaluate the incidence and timing of osteonecrosis involving multiple joints in 15 patients with LLy aged 9-21 years at diagnosis. Read More

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http://dx.doi.org/10.1002/pbc.28336DOI Listing

A Highly Selective and Sensitive Chemiluminescent Probe for Real-Time Monitoring of Hydrogen Peroxide in Cells and Animals.

Angew Chem Int Ed Engl 2020 May 29. Epub 2020 May 29.

Tel Aviv University, School of Chemistry, ISRAEL.

Selective and sensitive molecular probes for hydrogen peroxide (H 2 O 2 ), which plays diverse roles in oxidative stress and redox signalling, are urgently needed to investigate the physiological and pathological effects of H 2 O 2 . A lack of reliable tools for in vivo imaging has hampered the development of H 2 O 2 mediated therapeutics. By combining a specific tandem Payne/Dakin reaction with a chemiluminescent scaffold, H 2 O 2 -CL-510 was developed as a highly selective and sensitive probe for detection of H 2 O 2 both in vitro and in vivo . Read More

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http://dx.doi.org/10.1002/anie.202005429DOI Listing