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    Leukemia cutis in a patient with chronic lymphocytic leukemia presenting as bilateral helical nodules.
    SAGE Open Med Case Rep 2016 1;4:2050313X16683624. Epub 2016 Dec 1.
    Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine, Marshall University-Edwards Comprehensive Cancer Center, Huntington, WV, USA.
    Chronic lymphocytic leukemia, the most common adult leukemia worldwide, is considered an indolent but incurable non-Hodgkin lymphoma. Leukemia cutis is an uncommon manifestation of chronic lymphocytic leukemia. We present a case of an adult patient who presented with skin lesion of bilateral ears, which led to the diagnosis of chronic lymphocytic leukemia. Read More

    Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: A case report.
    Medicine (Baltimore) 2017 Feb;96(8):e6184
    Department of Hematology, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China.
    Rationale: Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.

    Patient Concerns: We report a case of paraneoplastic pemphigus linked to chronic lymphocytic leukemia in a 63-year-old man. Read More

    Sweet's syndrome associated with clonal hematopoiesis of indeterminate potential responsive to 5-azacitidine.
    Ther Adv Hematol 2017 Feb 29;8(2):91-95. Epub 2016 Nov 29.
    Department of Hematology/Oncology, The West Clinic, The University of Tennessee Health Science Center, Memphis, TN, USA.
    Sweet's syndrome (SS) is a rare condition characterized by the abrupt appearance of painful skin lesions due to neutrophilic dermal infiltration. Hematologic neoplasms, particularly acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs), have been commonly reported in association with SS. Clonal hematopoiesis of indeterminate potential (CHIP) is an emerging entity that is a precursor state to myeloid neoplasms. Read More

    Risk of other Cancers in Families with Melanoma: Novel Familial Links.
    Sci Rep 2017 Feb 15;7:42601. Epub 2017 Feb 15.
    Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
    A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful information about shared genetic and environmental risk factors and it may be relevant background data in clinical genetic counseling. Read More

    Effect of dietary phosphorus deficiency on the growth, immune function and structural integrity of head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella).
    Fish Shellfish Immunol 2017 Feb 10;63:103-126. Epub 2017 Feb 10.
    Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China. Electronic address:
    This study evaluates the effects of dietary phosphorus on the growth, immune function and structural integrity (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella) that were fed graded levels of available phosphorus (0.95-8.75 g/kg diet). Read More

    A case report of rare palmoplantar keratosis and nail dystrophy with imatinib.
    Ann Pharm Fr 2017 Feb 9. Epub 2017 Feb 9.
    Service of pharmacy, National institute of oncology, 10170 Rabat, Morocco.
    A 48-year-old woman developed palmoplantar hyperkeratosis during treatment with imatinib (400mg/day) for treatment of chronic myeloid leukemia. After 5months of treatment, she developed plantar lesions with yellow-brownish plaques and palmar desquamations. The skin biopsy has eliminated psoriasis. Read More

    Progression of cutaneous plasmacytoma to plasma cell leukemia in a dog.
    Vet Clin Pathol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
    A 5-year-old male neutered Bernese Mountain Dog was presented for cutaneous plasmacytoma, which was treated by surgical excision. Four months later, the dog developed multiple skin masses, hyphema, pericardial and mild bicavitary effusions, myocardial masses, and marked plasmacytosis in the peripheral blood. Circulating plasma cells expressed CD34 and MHC class II by flow cytometry. Read More

    Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.
    Mini Rev Med Chem 2017 Feb 8. Epub 2017 Feb 8.
    Laboratoire de Biotechnologie Microbienne et d'Ingénierie des Enzymes (LBMIE). Centre de Biotechnologie de Sfax, Université de Sfax, Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax,Tunisia.
    The inhibitory effects of four series of aryl butene derivatives, active against breast cancer, on the monophenolase activity of tyrosinase, in melanin-free ink from Sepia officinalis, have been studied. Hydroxytamoxifen 1, ferrociphenol 17 and several aryl butene analogs have shown strong antiproliferative activity on hormone-dependent and hormone-independent breast cancer cells and were evaluated in leukemia K562 cell proliferation. Their potential to induce skin depigmentation by evaluating their anti-tyrosinase activity was also estimated. Read More

    Effects of mogamulizumab in adult T-cell leukemia/lymphoma in clinical practice.
    Eur J Haematol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
    Objective: The efficacy of mogamulizumab in ATLL was reported in a previous phase 2 study. Compared with patients in clinical trials, however, most patients in real-life settings have demonstrated worse outcomes.

    Method: We retrospectively analyzed 96 patients with relapsed/refractory ATLL who received mogamulizumab treatment. Read More

    [A rare and mortal infection agent in patients with hematological malignancies: Saprochaete capitata].
    Mikrobiyol Bul 2016 Oct;50(4):613-620
    Gazi University Faculty of Medicine, Department of Hematology, Ankara, Turkey.
    Saprochaete capitata (formerly known as Geotrichum capitatum and Blastoschizomyces capitatus) is a rare invasive fungal agent that may lead to mortal clinical course in patients with hematological malignancies. This agent can be colonized in skin, lungs and intestines, and it can cause major opportunistic infections. Invasive systemic infections due to S. Read More

    Analysis of expression of FLI1 and MMP1 in American cutaneous leishmaniasis caused by Leishmania braziliensis infection.
    Infect Genet Evol 2017 Jan 21;49:212-220. Epub 2017 Jan 21.
    National Institute of Science and Technology in Tropical Diseases, Brazil and Federal University of Bahia, Salvador, Brazil. Electronic address:
    FLI1 (Friend leukemia virus integration 1) and IL6 (interleukin 6; IL-6) are associated with Leishmania braziliensis susceptibility. Cutaneous lesions show exaggerated matrix metalloproteinase 1 (MMP1). In other skin diseases, FLI1 promoter methylation reduces FLI1 expression, and low FLI1 down-regulates MMP1. Read More

    Trends and Patterns of Disparities in Cancer Mortality Among US Counties, 1980-2014.
    JAMA 2017 01;317(4):388-406
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Introduction: Cancer is a leading cause of morbidity and mortality in the United States and results in a high economic burden.

    Objective: To estimate age-standardized mortality rates by US county from 29 cancers.

    Design And Setting: Deidentified death records from the National Center for Health Statistics (NCHS) and population counts from the Census Bureau, the NCHS, and the Human Mortality Database from 1980 to 2014 were used. Read More

    Anthropometry in Long-Term Survivors of Acute Lymphoblastic Leukemia in Childhood and Adolescence.
    J Adolesc Young Adult Oncol 2017 Jan 24. Epub 2017 Jan 24.
    1 Service of Hematology-Oncology, McMaster Children's Hospital , Hamilton, Ontario, Canada .
    Purpose: Body mass index (BMI) is an inadequate measure of nutritional status in children and adolescents with cancer as it does not distinguish muscle from adipose tissue. However, arm anthropometry offers simple assessments of fat mass and lean body mass; especially valuable in low- and middle-income countries where the great majority of young people with cancer live and access to sophisticated expensive measures of body composition is markedly limited.

    Methods: The nutritional status of 75 long-term survivors of acute lymphoblastic leukemia was assessed by arm anthropometry, in addition to BMI, in a cross-sectional cohort study. Read More

    Stromal Cell-Derived Growth Factor-1 Alpha-Elastin Like Peptide Fusion Protein Promotes Cell Migration and Revascularization of Experimental Wounds in Diabetic Mice.
    Adv Wound Care (New Rochelle) 2017 Jan;6(1):10-22
    Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey.; Center for Engineering in Medicine, Massachusetts General Hospital and Shriners Burns Hospital, Boston, Massachusetts.
    Objective: In previous work, we demonstrated the development of a novel fusion protein containing stromal cell-derived growth factor-1 alpha juxtaposed to an elastin-like peptide (SDF1-ELP), which has similar bioactivity, but is more stable in elastase than SDF1. Herein, we compare the ability of a single topical application of SDF1-ELP to that of SDF1 in healing 1 × 1 cm excisional wounds in diabetic mice. Approach: Human Leukemia-60 cells were used to demonstrate the chemotactic potential of SDF1-ELP versus SDF1 in vitro. Read More

    Metabolism, toxicity and anticancer activities of arsenic compounds.
    Oncotarget 2017 Jan 18. Epub 2017 Jan 18.
    Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, China.
    A variety of studies indicated that inorganic arsenic and its methylated metabolites have paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have shown that long term exposure to arsenic can increase the risk of cancers of lung, skin or bladder in man, which is probably associated with the arsenic metabolism. In fact, the enzymatic conversion of inorganic arsenic by Arsenic (+3 oxidation state) methyltransferase (AS3MT) to mono- and dimethylated arsenic species has long been considered as a major route for detoxification. Read More

    Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report.
    Mol Clin Oncol 2016 Dec 19;5(6):745-749. Epub 2016 Oct 19.
    Department of Internal Medicine, Division of Hematology, Istanbul Medipol University, Istanbul 34214, Turkey.
    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with acute lymphoblastic leukemia (ALL). The curative potential of allo-HSCT for ALL is, in part, due to the graft-vs.-leukemia (GVL) effect, in addition to the intensive conditioning chemo-radiotherapy. Read More

    Identification of Merkel Cell Polyomavirus from a Patient with Acute Myeloid Leukemia.
    Genome Announc 2017 Jan 19;5(3). Epub 2017 Jan 19.
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, Illinois, USA
    Merkel cell polyomavirus (MCPyV) is an oncogenic virus associated with Merkel cell carcinoma, an aggressive form of skin cancer with a high (>30%) mortality rate. The virus has a high incidence in patients with immunosuppressed conditions, such as AIDS or leukemia, or following organ transplantation. Here, we report the complete genomic sequence of MCPyV identified from a blood sample from a patient with acute myeloid leukemia. Read More

    Impact of pretransplant induction therapy on autologous stem cell transplantation for patients with newly diagnosed POEMS syndrome.
    Leukemia 2017 Feb 14. Epub 2017 Feb 14.
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) is a rare plasma cell dyscrasia sometimes treated with a haematopoietic cell autotransplant. We analyzed data from 138 subjects with newly diagnosed POEMS syndrome receiving a autotransplant at our center. Thirty-two subjects with severe end-organ dysfunction ineligible for immediate autotransplant received pretransplant therapy, which made a subsequent autotransplant feasible. Read More

    FISH identifies a KAT6A/CREBBP fusion caused by a cryptic insertional t(8;16) in a case of spontaneously remitting congenital acute myeloid leukemia with a normal karyotype.
    Pediatr Blood Cancer 2017 Jan 18. Epub 2017 Jan 18.
    Department of Pediatrics, IWK Health Centre/Dalhousie University, Halifax, Nova Scotia, Canada.
    Cytogenetics can inform risk stratification in pediatric acute myeloid leukemia (AML). We describe the first case of a newborn with leukemia cutis found to have AML harboring a cryptic insertional t(8;16)(p11.2;p13. Read More

    The effectiveness of radiotherapy for leukemia cutis.
    J Cancer Res Clin Oncol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.
    Background: Leukemia cutis (LC) is a rare clinical presentation of leukemia that is associated with poor prognosisabs. To date, the value of radiotherapy (RT) for the treatment of LC remains controversial. Therefore, the aim of this study was to analyse the effectiveness of various RT doses for LC. Read More

    Immune stimulation during chemotherapy increases incidence of acute graft versus host disease in acute myeloid leukemia: A study on behalf of SFGM-TC and ALFA.
    Leuk Res 2017 Jan 5;54:12-16. Epub 2017 Jan 5.
    Saint Louis Hospital, Hematology Department, Paris, France; Mediterranean Center of Molecular Medicine, INSERM U1065, Nice, France. Electronic address:
    60-70% of AML patients have an indication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) during their treatment. Graft versus host disease (GvHD), the major cause of mortality and comorbidities post-transplantation, develops by immunological mechanism and decides greatly prognosis and quality of life (QoL) of graft recipient. Current GvHD prophylaxis is not personalized. Read More

    Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell-Derived Factor-1 Activity in Model Diabetic Environments.
    Adv Wound Care (New Rochelle) 2016 Dec;5(12):527-538
    Department of Biomedical Engineering, Rutgers University , Piscataway, New Jersey.
    Objective: In diabetes, hyperglycemia causes the accumulation of advanced glycation end products (AGEs) that trigger reactive oxygen species (ROS) generation through binding the receptor for AGEs (RAGE). Because exogenous growth factors have had little success in enhancing chronic wound healing, we investigated whether hyperglycemia-induced AGEs interfere with cellular responses to extracellular signals. We used stromal cell-derived factor-1 (SDF-1), an angiogenic chemokine also known to promote stem cell recruitment in skin wounds. Read More

    Clonal reticulohistiocytosis of the skin and bone marrow associated with systemic mastocytosis and acute myeloid leukaemia.
    Histopathology 2017 Jan 11. Epub 2017 Jan 11.
    Division of Pathology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
    Aims: The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent precursor to more aggressive forms of disease.

    Methods And Results: A 59-year-old man with diffuse cutaneous reticulohistiocytosis, experienced bone marrow localisation of the disease, with associated systemic mastocytosis and acute myeloid leukaemia. Cytogenetic analyses of the bone marrow aspirate revealed the presence of a derivative chromosome giving rise to a partial trisomy of chromosome 1q and a partial monosomy of chromosome 9q. Read More

    Cancer incidence in cohorts of workers in the rubber manufacturing industry first employed since 1975 in the UK and Sweden.
    Occup Environ Med 2017 Jan 6. Epub 2017 Jan 6.
    University of Strathclyde Institute of Global Public Health, Lyon, France.
    Objectives: Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK.

    Methods: Two cohorts of rubber workers employed for at least 1 year were analysed. Read More

    Blastic Plasmocytoid Dendritic Cell Neoplasm With Skin and Myeloid Location.
    J Pediatr Hematol Oncol 2017 Jan 5. Epub 2017 Jan 5.
    Department of Pediatric Oncology, Haematology and Chemotherapy, Upper Silesia Children's Care Health Centre, Medical University of Silesia, Katowice, Poland.
    Blastic plasmocytoid dendritic cell neoplasm is one of the aggressive hematopoietic malignancy with predilection for the skin. It is a tumor derived from the plasmocytoid dendritic precursor cells. Skin is its most common location; however, it may also affect bone marrow, lymph nodes, or spleen. Read More

    Clinical outcome of myeloid sarcoma in adult patients and effect of allogeneic stem cell transplantation. Results from a multicenter survey.
    Leuk Res 2017 Feb 20;53:74-81. Epub 2016 Dec 20.
    Division of Hematology and Bone Marrow Transplantation, Azienda Sanitaria-Universitaria Integrata, University of Udine, Italy.
    Introduction: Myeloid Sarcoma (MS) is a rare hematologic myeloid neoplasm that can involve any site of the body. It can occur as an exclusively extramedullary form or it can be associated with an acute myeloid leukemia (AML), a chronic myeloproliferative neoplasm (MPN) or a myelodysplastic syndrome (MDS) at onset or at relapse. The rarity of MS does not enable prospective clinical trials and therefore a specific multicenter register can be useful for the clinical and biological studies of this rare disease. Read More

    SU-F-T-83: Infant Total Skin Electron Therapy Using Five Fields Technique.
    Med Phys 2016 Jun;43(6):3480
    University of Kansas Hospital, Overland Park, KS.
    Purpose: We were presented with a 9 month old boy with Relapsed Acute Myeloid Leukemia (AML) involving the skin. The plan was to treat the entire skin using 6 MeV electrons with the infant under complete anesthesia. The purpose of this work is to commission the 6 MeV electron beam and to develop a technique that can be used to deliver total skin dose to infants with minimal patient immobilization. Read More

    Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010.
    Neuro Oncol 2016 Dec 29. Epub 2016 Dec 29.
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio (A.S.Z.); Department of Statistical Sciences, Sandia National Laboratories, Albuquerque, New Mexico (A.S.Z.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (Q.T.O., L.R., D.M.P., J.S.B.); Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, Illinois (Q.T.O., C.K., J.S.B.); Brain Tumor and Neuro-Oncology Center, University Hospitals Case Medical Center, Cleveland, Ohio (L.R.); Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio (D.M.P.)
    Background: Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0-14 y), adolescent and young adult (AYA) (15-39 y), and adult (40+ y).

    Methods: Complete prevalence proportions were estimated using a novel regression method extended from the Completeness Index Method, which combines survival and incidence data from multiple sources. Read More

    Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity.
    Cancer Lett 2017 Mar 26;389:78-85. Epub 2016 Dec 26.
    International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111 - Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007, Lyon, France; Equipe labellisée "Ligue Nationale Contre le Cancer", France. Electronic address:
    HTLV-1 causes Adult T cell Leukemia/Lymphoma (ATLL) in humans. We describe an ATL-like disease in a 9 year-old female baboon naturally infected with STLV-1 (the simian counterpart of HTLV-1), with a lymphocyte count over 10(10)/L, lymphocytes with abnormal nuclear morphology, and pulmonary and skin lesions. The animal was treated with a combination of AZT and alpha interferon. Read More

    Fatal Scopulariopsis brumptii in a Pediatric Immunocompromised Host.
    Fetal Pediatr Pathol 2017 Feb 29;36(1):82-86. Epub 2016 Dec 29.
    b Children's Hospital of New Orleans , Department of Pathology , New Orleans , Louisiana , USA.
    Scopulariopsis species cause a broad range of disease, from superficial skin infections to often fatal disseminated disease in the immunocompromised that is refractory to standard antifungal treatment. This report describes the first case of fatal disseminated Scopulariopsis brumptii in a pediatric patient with hyper-IgM syndrome status post bone marrow transplant. Read More

    Idelalisib-induced colitis and skin eruption mimicking graft-versus-host disease.
    Clin J Gastroenterol 2016 Dec 26. Epub 2016 Dec 26.
    Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO, USA.
    Introduction: Idelalisib is a selective inhibitor of the delta isoform of phosphatidylinositol 3-kinase which was approved by the United States Federal Drug Administration in 2014 for the treatment of relapsed chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma. Drug-induced injury of the gastrointestinal tract is a relatively frequent but usually under-recognized disease entity.

    Case Presentation: We report the case of a 56-year-old male with a history of relapsed follicular lymphoma status post allogenic bone marrow transplant who developed severe diarrhea with a skin eruption mimicking graft-versus-host disease (GVHD) 6 months after starting idelalisib. Read More

    Ex Vivo CD34(+)-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response.
    Biol Blood Marrow Transplant 2017 Mar 23;23(3):452-458. Epub 2016 Dec 23.
    Adult Bone Marrow Transplant Service, Division of Hematology/Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address:
    Ex vivo CD34(+)-selected T cell depletion (TCD) has been developed as a strategy to reduce the incidence of graft-versus-host disease (GVHD) after allogeneic (allo) hematopoietic stem cell transplantation (HSCT). Clinical characteristics, treatment responses, and outcomes of patients developing acute (aGVHD) and chronic GVHD (cGVHD) after TCD allo-HSCT have not been well established. We evaluated 241 consecutive patients (median age, 57 years) with acute leukemia (n = 191, 79%) or myelodysplastic syndrome (MDS) (n = 50, 21%) undergoing CD34(+)-selected TCD allo-HSCT without post-HCST immunosuppression in a single institution. Read More

    Cellular arsenic transport pathways in mammals.
    J Environ Sci (China) 2016 Nov 29;49:38-58. Epub 2016 Oct 29.
    Department of Physiology and Membrane Protein Disease Research Group, University of Alberta, Edmonton, AB, T6G 2H7, Canada; Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada. Electronic address:
    Natural contamination of drinking water with arsenic results in the exposure of millions of people world-wide to unacceptable levels of this metalloid. This is a serious global health problem because arsenic is a Group 1 (proven) human carcinogen and chronic exposure is known to cause skin, lung, and bladder tumors. Furthermore, arsenic exposure can result in a myriad of other adverse health effects including diseases of the cardiovascular, respiratory, neurological, reproductive, and endocrine systems. Read More

    [Patient reported outcome of tyrosine kinase inhibitor related side effects and their impact on daily life in Chinese patients with chronic myeloid leukemia in the chronic phase].
    Zhonghua Xue Ye Xue Za Zhi 2016 Nov;37(11):929-935
    Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
    Objective: To explore the impact of patient reported outcome of tyrosine kinase inhibitor (TKI) related side effects on daily life in Chinese patients with chronic myeloid leukemia (CML) in the chronic phase (CP). Methods: From May to November in 2014, anonymous questionnaires were distributed to adult CML patients who were receiving TKI treatment in China. The impact of TKI-related side effects on daily life were assessed by the score of 1 (no impact) to 5 (high impact) from patient self-report. Read More

    Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold.
    ACS Med Chem Lett 2016 Dec 21;7(12):1050-1055. Epub 2016 Sep 21.
    College of Pharmacy, Dalian Medical University , Dalian 116044, P. R. China.
    Based on the pyrimidine skeleton of EGFR(T790M) inhibitors, a series of N,9-diphenyl-9H-purin-2-amine derivatives were identified as effective BTK inhibitors. Among these compounds, inhibitors 10d, 10i, and 10j, possessing IC50 values of 0.5, 0. Read More

    Graft-Versus-Host Disease in Adolescents and Young Adults (15-24 Years Old) After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia in First Complete Remission.
    J Adolesc Young Adult Oncol 2016 Dec 16. Epub 2016 Dec 16.
    1 Unité d'Hématologie-Adolescents et Jeunes Adultes, Hôpital Saint-Louis, EA-3518, Université Paris 7 Denis Diderot , Paris, France .
    Purpose: Adolescents and young adults (AYAs) with cancer are a unique group of patients in terms of disease incidence and biology, outcome, and psychosocial needs. This study aims to correlate the risk of graft-versus-host disease (GvHD) and age in a population of children and young adults with acute leukemia undergoing hematopoietic stem cell transplantation (HSCT) in first complete remission (CR).

    Methods: We analyzed the outcome of 153 consecutive children (<15 years), AYAs (15-24 years), and adults (25-35 years) with lymphoblastic or myeloid acute leukemia in first CR who underwent HSCT with matched donors after myeloablative conditioning. Read More

    Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
    Turk J Pediatr 2016 ;58(2):152-158
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara, Turkey.
    The methylenetetrahydrofolate reductase (MTHFR) gene plays a key role in carcinogenesis through its effects on DNA synthesis and methylation and also has a significant role in the etiology of many disorders, such as diabetes, migraine, and cardiovascular disease. Neurofibromatoses (NF) are autosomal dominant inherited diseases that can affect tissues such as bone and skin and predispose individuals to tumor development in various parts of the nervous system or body. Optic nerve glioma and brain tumors are common in children with NF, and leukemia and lymphoma incidence is also higher than normal. Read More

    Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia.
    Case Rep Hematol 2016 13;2016:1257679. Epub 2016 Nov 13.
    Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada.
    Current therapies for acute myeloid leukemia (AML), failing induction, are rarely effective. We report our experience in 4 patients with AML who received 16 Gy TBI prior to allogeneic hematopoietic cell transplantation (alloHCT), between June 2010 and May 2011. Patients were 20 to 55 years of age, 2 with relapsed disease and 2 with AML failing induction. Read More

    Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis.
    Case Rep Med 2016 10;2016:1298375. Epub 2016 Nov 10.
    Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, India.
    Leukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. It is common in congenital leukemia and acute myeloid leukemia. However, LC has rarely been reported with mixed phenotypic acute leukemia (MPAL). Read More

    Pharmacotherapeutic Considerations for Individuals with Down Syndrome.
    Pharmacotherapy 2017 Feb 13;37(2):214-220. Epub 2017 Jan 13.
    Department of Pharmaceutical Sciences, The School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, New York.
    Down syndrome (DS; trisomy 21) is the most common survivable disorder due to aneuploidy. Individuals with DS may experience multiple comorbid health problems including congenital heart defects, endocrine abnormalities, skin and dental problems, seizure disorders, leukemia, dementia, and obesity. These associated conditions may necessitate pharmacotherapeutic management with various drugs. Read More

    Granulocytic sarcoma of the pancreas on 18F-FDG PET/CT: A case report.
    Medicine (Baltimore) 2016 Dec;95(49):e5570
    aDepartments of Hematology and Oncology bDiagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Rationale: Granulocytic sarcoma (GS) is defined as leukemia infiltration in any organ other than the bone marrow. GS rarely occurs in the pancreas. Here, we present the first report of GS in the pancreas on F-fluorodexyglucose positron emission tomography/computed tomography (F-FDG PET/CT). Read More

    BCR-ABL-specific T-cell therapy in Ph+ ALL patients on tyrosine-kinase inhibitors.
    Blood 2017 Feb 7;129(5):582-586. Epub 2016 Dec 7.
    Section of Hematology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Azienda Ospedaliera Universitaria (AOU) Policlinico, Modena, Italy.
    Although the emergence of bone marrow (BM)-resident (p190)BCR-ABL-specific T lymphocytes has been correlated with hematologic and cytogenetic remissions in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) undergoing maintenance tyrosine-kinase inhibitor treatment, little is known about the possibility of culturing these cells ex vivo and using them in T-cell therapy strategies. We investigated the feasibility of expanding/priming (p190)BCR-ABL-specific T cells in vitro by stimulation with dendritic cells pulsed with (p190)BCR-ABL peptides derived from the BCR-ABL junctional region and alternative splicing, and of adoptively administering them to patients with relapsed disease. We report on the feasibility of producing clinical-grade BCR-ABL-specific cytotoxic T lymphocytes (CTLs), endowed with antileukemia activity, from Ph(+) ALL patients and healthy donors. Read More

    Treatment of blastic plasmacytoid dendritic cell neoplasm.
    Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):16-23
    Duke Cancer Institute, Durham, NC.
    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy with no defined standard of care. BPDCN presents most commonly with skin lesions with or without extramedullary organ involvement before leukemic dissemination. As a result of its clinical ambiguity, differentiating BPDCN from benign skin lesions or those of acute myeloid leukemia with leukemia cutis is challenging. Read More

    Invasive Squamous Cell Carcinoma of the Scalp and Calvarium: A Multidisciplinary Approach.
    Eplasty 2016 8;16:e29. Epub 2016 Nov 8.
    Department of Plastic and Reconstructive Surgery, St. Joseph's Regional Medical Center, Paterson, NJ.
    Objective: The correlation between immunosuppression-associated skin cancer and lymphoma has been well established. This includes squamous cell carcinoma and chronic lymphocytic leukemia. When a lesion requires excision, reconstruction can be challenging based on the depth and size of the tumor. Read More

    A Clinicopathological Analysis of Primary Cutaneous Lymphomas: A 6-year Observational Study at a Tertiary Care Center of South India.
    Indian J Dermatol 2016 Nov-Dec;61(6):608-617
    Department of Pathology, Government Medical College, Kozhikode, Kerala, India.
    Background: Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India.

    Aim: To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patients.

    Materials And Methods: This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. Read More

    CD30 Expression Is Rare in Myeloid Leukemia Cutis: A Study of 55 Cases and Implications for Routine Diagnostic Algorithms.
    Am J Dermatopathol 2016 Nov 22. Epub 2016 Nov 22.
    *Department of Dermatology, Weill Cornell Medical College, New York, NY; and †Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.
    Expression of CD30 in blastoid cutaneous infiltrates typically signifies a CD30 lymphoproliferative disorder, often requiring minimal immunohistochemical workup, if clinically consonant. However, myeloid and other hematologic malignancies often express CD30. We retrospectively examined the prevalence of CD30 expression in 41 patients (median age 59) and 55 biopsies with the diagnosis of leukemia cutis (LC) to determine whether an extensive immunohistochemical workup is warranted in all large, round cell CD30 cutaneous infiltrates. Read More

    Treatment Emergent Agranulocytosis with Skin and Gingival Lesions in a Chronic Lymphocytic Leukemia Patient: A Case Report.
    J Clin Diagn Res 2016 Oct 1;10(10):ZD13-ZD16. Epub 2016 Oct 1.
    Professor and Head, Department of Oral Pathology and Microbiology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
    Chronic Lymphocytic Leukaemia (CLL) is a monoclonal lymphoid malignancy characterized by progressive accumulation of small, mature but functionally incompetent neoplastic lymphocytes in the peripheral blood, bone marrow and lymphoid organs. Patients present a variable course and may not require early intervention unlike other malignancies. Patients with rapidly deteriorating blood counts, and organomegaly need treatment. Read More

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