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Cleve Clin J Med 2019 Feb;86(2):85-86

Department of Hematology and Oncology, Captain James A. Lovell Federal Healthcare Center, North Chicago, IL, USA.

Eur J Haematol 2019 Feb 10. Epub 2019 Feb 10.

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Objective: This prospective, observational, postmarketing surveillance was conducted to evaluate the safety and effectiveness of mogamulizumab, an anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, in patients with CCR4-positive, relapsed or refractory (r/r) adult T-cell leukemia-lymphoma (ATL) in Japan.

Method: All patients were scheduled to receive intravenous infusions of mogamulizumab 1.0 mg/kg once weekly for 8 weeks, alone or in combination with other modalities. Read More

Dermatol Res Pract 2019 13;2019:9891270. Epub 2019 Jan 13.

Intermediate Care Unit, King Abdulaziz Medical City (KAMC), National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia.

Skin manifestations are common in hematology ward patients and can result from infection, malignancy, or chemotherapy. The purpose of this study was to identify the most common dermatological problems encountered in the adult hematology ward at King Abdullah Specialist Children Hospital (KASCH). This was retrospective chart review of 78 dermatology consultations based on electronic health records for all inpatients in hematology wards at KASCH between January 2016 and December 2017. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14344

Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy. This disease almost always presents with cutaneous involvement.

Patient Concerns: The 1st patient was a 16-year-old girl who presented with recurrent epistaxis. Read More

Pediatr Blood Cancer 2019 Feb 7:e27647. Epub 2019 Feb 7.

Departments of Pediatrics, Pathology and Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: At least 80% of children with cancer live in low- and middle-income countries where the prevalence of malnutrition and socioeconomic disadvantage is high. We examined the relationship between nutritional status (NS), assessed by arm anthropometry, and socioeconomic status (SES) in children diagnosed with cancer at Unidad Nacional de Oncologia Pediatrica (UNOP) in Guatemala over a three-year period.

Method: Patients aged 0 to 18 years of age diagnosed between January 2015 and December 2017 were included. Read More

Rinsho Ketsueki 2019 ;60(1):22-27

Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University.

A 44-year-old male was diagnosed with acute myeloid leukemia with a complex karyotype. He underwent bone marrow transplantation using an HLA 6/6 antigen-matched sibling donor, but developed chronic graft-versus-host disease (cGVHD) with skin erythema and oral and esophageal lichen planus changes. Treatment with a combination of prednisolone and cyclosporine was initiated on day 646 after transplantation, but oral symptoms persisted. Read More

Lancet Haematol 2019 Feb;6(2):e100-e109

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Therapeutic approaches for B-cell malignancies continue to evolve, especially with regard to combination approaches. We assessed the safety and efficacy of the triplet ublituximab, umbralisib, and ibrutinib in patients with advanced B-cell malignancies.

Methods: We did an open-label, phase 1 study with dose-escalation and dose-expansion phases, at five centres in the USA. Read More

Dermatol Ther 2019 Feb 1:e12849. Epub 2019 Feb 1.

Department of Dermatology, People's Hospital of Peking University, Beijing 100044, China.

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Tetra-arsenic tetra-sulfide (As S ), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects. In our previous study, BXSB lupus-prone mice treated with As S has showed improved monocytosis, decreased serum interleukin-6 (IL-6) and suppressed skin, liver and renal lesions with well-tolerance. Read More

Br J Haematol 2019 Jan 31. Epub 2019 Jan 31.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Read More

Immunol Med 2019 Jan 31:1-8. Epub 2019 Jan 31.

a Laboratory Molecular Genetics of Hematology Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.

Chronic active Epstein-Barr virus infection (CAEBV) is one of the Epstein-Barr virus (EBV)-positive T- or NK-cell lymphoproliferative diseases. It is characterized by clonal proliferation of EBV-infected T or NK cells and their infiltration into systemic organs, leading to their failure. Inflammatory symptoms, fever, lymphadenopathy and liver dysfunction are main clinical findings of CAEBV. Read More

Eur J Dermatol 2018 Dec;28(6):809-817

University of Utah, Department of Dermatology, Salt Lake City, Utah, USA, Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Aleukemic leukemia cutis (ALC) is an extremely rare cutaneous manifestation of an aggressive systemic hematological malignancy, associated with dermal infiltration by leukemic cells preceding peripheral blood involvement. This condition is associated with poor outcome, and dermatologists are often responsible for making the initial diagnosis in a timely fashion. To describe a case of ALC and review the literature with an emphasis on the clinical features, summarizing the cutaneous manifestations of this rare systemic disorder. Read More

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

Radiat Oncol 2019 Jan 28;14(1):17. Epub 2019 Jan 28.

School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: Helical irradiation of the total skin (HITS) was modified as simultaneous integrated boost (SIB)-helical arc radiotherapy of total skin (HEARTS) technique and applied to an acute myeloid leukemia (AML) patient with disseminated leukemia cutis.

Methods: The original HITS plan was revised for different regimens, i.e. Read More

BMC Infect Dis 2019 Jan 25;19(1):85. Epub 2019 Jan 25.

Department of Internal Medicine, St Antonius Hospital, Nieuwegein/ Utrecht, Koekoekslaan 1, 3435, CM, Nieuwegein, The Netherlands.

Background: Ecthyma gangrenosum is a cutaneous infectious usually associated with P. aeruginosa. It usually develops In patients with an underlying immunodeficiency. Read More

Int J Hematol 2019 Jan 24. Epub 2019 Jan 24.

Department of Hematology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Watchful waiting (WW) is among the treatment options indicated for patients with indolent adult T-cell leukemia-lymphoma (ATL). However, we previously showed that the long-term prognosis of patients with smoldering and chronic ATL is often worse than expected, with many undergoing transformation to aggressive ATL. To identify clinical features associated with transformation of smoldering/chronic ATL, we retrospectively analyzed the clinical features of 44 patients (14 smoldering and 30 chronic) who experienced transformation during WW. Read More

JAAD Case Rep 2019 Feb 12;5(2):121-123. Epub 2019 Jan 12.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illionois.

Mediterr J Hematol Infect Dis 2019 1;11(1):e2019001. Epub 2019 Jan 1.

Klinik für Innere Medizin II, Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

CMV associated tissue-invasive disease is associated with a considerable risk of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Recently, the terminase inhibitor letermovir (LMV) has been approved for prophylaxis of CMV infection in HSCT. We hereby report a 60-year-old female experiencing CMV reactivation after HSCT in a CMV seronegative donor-constellation. Read More

Adv Clin Exp Med 2019 Jan 17. Epub 2019 Jan 17.

Department of Clinical Pharmacology, Wroclaw Medical University, Poland.

Background: Chronic lymphocytic leukemia (CLL), the most common form of adult leukemia in Caucasian populations, is characterized by a decrease in anti-infective immunity. Clinical evidence of antiviral immunity decrease is the reactivation of herpes virus in the form of skin lesions. In Europe, rubella infection is common and creates lifelong persistence of IgG antibodies. Read More

Pediatr Ann 2019 Jan;48(1):e30-e35

Certain rashes and cutaneous lesions in a newborn can be clues to more concerning diseases and conditions if recognized and evaluated promptly. Langerhans cell histiocytosis, cutaneous forms of cancer (such as leukemia cutis, neuroblastoma, and rhabdomyosarcoma), developmental abnormalities such as neural tube or spinal dysraphism, and aplasia cutis congenita, nutritional deficiency, and immunodeficiency all have a range of cutaneous findings that will be reviewed herein to guide diagnosis and management. [Pediatr Ann. Read More

Appl Immunohistochem Mol Morphol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei.

Granulomatous reaction is not uncommon in histopathology, with various etiologies in different organs and geographic regions. Lymphoma is one of the underlying causes of granuloma; and sometimes the neoplastic cells may be masked by the granulomatous reaction. In this report, we present our experience with 7 lymphoma cases of various histologic types with coexisting granuloma to show the diagnostic challenges. Read More

Cureus 2018 Nov 3;10(11):e3539. Epub 2018 Nov 3.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kota Bharu, MYS.

Acute lymphoblastic leukemia (ALL) manifestations in a child are varied. We report a unique and rare presentation of acute lymphoblastic leukemia in a child who presented with frontal swelling involving bilateral upper lids. A previously healthy one-year-old girl presented with progressively increasing frontal swelling of seven months duration. Read More

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):65-70

Second Orthopedic Division, Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Italy.

Cryotherapy, also called Cryoablation (CA), is a technique that provides a local treatment to various pathological conditions. In Musculoskeletal tumours management, Cryoablation is well accepted and validated as a treatment in palliative cures for metastatic patients. Recently, CA has been proposed also as an alternative to radiofrequency ablation in osteoid osteoma and other benign tumour treatment with promising results. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):11-16

Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China.

To investigate the clinical presentation, clinicopathologic features, diagnosis and differential diagnosis of adult T cell leukemia/lymphoma (ATLL). Four cases of ATLL from Fujian Cancer Hospital between October 2017 and May 2018 were analyzed using hematoxylin-eosin and immunohistochemical stains and polymerase chain reaction (PCR) for HTLV-1 provirus genes. The relevant literature was reviewed. Read More

Am J Clin Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Assistance Publique-Hôpitaux de Paris, Département de Pathologie, Hôpital Saint-Louis, Paris, France.

Neutrophilic dermatoses (ND) are a group of conditions characterized by an aseptic accumulation of polymorphonuclear leukocytes in the skin. Occurrence of ND in association with myeloid malignancies, mainly myelodysplastic syndrome and myelogenous acute leukemia, is not rare and is often associated with a poor prognosis. Recent findings have improved understanding of the pathophysiology of myeloid malignancy-associated ND. Read More

Clin Exp Dermatol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology, Venereology and Oncodermatology, University of Pecs, Pecs, Hungary.

Leukaemia cutis is a relatively rare manifestation in chronic lymphocytic leukaemia, characterized by a diverse morphology of skin lesions. We report two patients who developed zosteriform skin symptoms; however, the histological analysis revealed leukaemia infiltration as the cause of their symptoms. Contrary to previous reports, varicella zoster virus DNA was detectable in the lesions. Read More

Rinsho Ketsueki 2018 ;59(12):2567-2573

Department of Hematology, University of Tsukuba Hospital.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease that develops with a skin lesion and is often accompanied by leukemic transformation. The normal counterparts of BPDCN tumor cells are progenitors of plasmacytoid dendritic cells, whereas the origins are thought to be hematopoietic stem cells. Approximately 10%-20% of BPDCN patients develop other hematologic malignancies, including chronic myelomonocytic leukemia (CMML). Read More

Front Immunol 2018 18;9:3016. Epub 2018 Dec 18.

Department of Hematology, Leiden University Medical Center, Leiden, Netherlands.

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Therefore, donor CD4 T-cells after allogeneic stem cell transplantation (alloSCT) may mediate graft-vs.-leukemia reactivity without graft-vs. Read More

Planta Med 2019 Jan 4. Epub 2019 Jan 4.

Graduate School of Energy and Environment, Korea University, Seoul, South Korea.

has been traditionally used as a medicinal plant owing to its anti-inflammatory, anthelmintic, tonic, antihyperglycemic, and diaphoretic properties. We hypothesized that might have therapeutic potential in alleviating allergy and atopic dermatitis. Thus, we investigated the inhibitory effects of extract against allergic responses and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like dorsal skin lesions using immunoglobulin E-sensitized rat basophilic leukemia-2H3 mast cells and NC/Nga mice. Read More

J Ethnopharmacol 2019 Mar 27;232:193-200. Epub 2018 Dec 27.

School of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh 173212, India. Electronic address:

ROYLEA CINEREA (D.DON) BAILLON: Roylea cinerea (D.Don) Baillon family Lamiaceae is a shrub of the monotypic genus. Read More

Cell Death Discov 2018 18;4:117. Epub 2018 Dec 18.

1Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, Saint Louis, MO 63108 USA.

Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-induced depletion of neural stem/progenitor cells in the subgranular zone of the dentate gyrus in the hippocampus where neurogenesis occurs is considered largely responsible for deficiencies such as learning, memory, and spatial information processing in patients subjected to cranial irradiation. Similarly, IR therapy-induced intestinal injuries such as diarrhea and malabsorption are common side effects in patients with gastrointestinal tumors and are believed to be caused by intestinal stem cell drop out. Read More

Ann Pathol 2019 Feb 19;39(1):40-46. Epub 2018 Dec 19.

Centre hospitalier universitaire Aristide le Dantec, service d'hématologie, avenue Pasteur, BP 3001, Dakar, Sénégal.

Adult T-cell leukemia/lymphoma (ATLL) is a rare medical condition and a diagnosis that ought to be considered for patients living in an area endemic for the HTLV-1 virus (human T-lymphotrophic virus) where a T-cell lymphoproliferative diagnosis has been made. The cutaneous clinical forms may be the first manifestation of the disease. We report here an observation in a 60-year-old Senegalese woman whose skin lesions were sampled to reveal the ATLL immunophenotypic profile CD4+, CD25+, FoxP3-, and CD7-. Read More

Dermatol Ther 2018 Dec 14:e12804. Epub 2018 Dec 14.

City of Hope Comprehensive Cancer Center, Cutaneous Lymphoma Program, Toni Stephenson Lymphoma Center, Duarte, California.

Cutaneous T-cell lymphomas (CTCL) are a relatively rare and heterogeneous group of non-Hodgkin lymphomas that typically present in the skin. The majority of patients with CTCL experience pruritus, which can interfere with daily activities, significantly impact quality of life, and is typically uncontrolled by standard anti-itch therapies. Several lymphoma treatments have reported anti-pruritic effects including romidepsin, a potent class 1 selective histone deacetylase inhibitor approved for the treatment of patients with CTCL who have had at least one prior systemic therapy. Read More

Lancet Oncol 2019 Jan 3;20(1):43-56. Epub 2018 Dec 3.

Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA.

Background: Both single-agent ibrutinib and chlorambucil plus obinutuzumab have shown superior efficacy to chlorambucil monotherapy and are standard first-line treatments in chronic lymphocytic leukaemia. We compared the efficacy of the combination of ibrutinib plus obinutuzumab with chlorambucil plus obinutuzumab in first-line chronic lymphocytic leukaemia or small lymphocytic lymphoma.

Methods: iLLUMINATE is a multicentre, randomised, open-label, phase 3 trial done at 74 academic and community hospitals in Australia, Canada, Israel, New Zealand, Russia, Turkey, the EU, and the USA in patients with previously untreated chronic lymphocytic leukaemia or small lymphocytic lymphoma, either aged 65 years or older or younger than 65 years with coexisting conditions. Read More

Arthritis Res Ther 2018 Dec 6;20(1):270. Epub 2018 Dec 6.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.

Background: Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types.

Methods: Online databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Read More

Case Rep Oncol Med 2018 14;2018:1736854. Epub 2018 Nov 14.

Specialist Care Australia, Launceston, Tasmania, Australia.

Hairy cell leukemia (HCL) and Merkel cell carcinoma (MCC) are two rare malignancies with distinct cells of origin. HCL is a lymphoid malignancy of mature B cells, and MCC derives from neuroendocrine cell origin. HCL has a favorable prognosis with most patients achieving long-term remission and potential cure. Read More

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.

Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.

Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background: Trappin-2/pre-elafin is an endogenous inhibitor of human neutrophil elastase involved in inflammation, innate immunity and vascular remodelling, which consist of the complex pathological process of systemic sclerosis (SSc).

Objectives: To clarify the potential role of trappin-2 in SSc.

Methods: Serum trappin-2 levels were determined by enzyme-linked immunosorbent assay in 51 SSc and 18 healthy subjects. Read More

Leukemia 2018 Dec 5. Epub 2018 Dec 5.

Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.

Sézary syndrome (SS) is a rare and aggressive variant of Cutaneous T-Cell Lymphoma characterized by neoplastic distribution mainly involving blood, skin, and lymph-node. Although a role of the skin microenvironment in SS pathogenesis has long been hypothesized, its function in vivo is poorly characterized. To deepen this aspect, here we compared skin to blood-derived SS cells concurrently obtained from SS patients highlighting a greater proliferation-index and a PI3K/AKT/mTORC1 pathway activation level, particularly of mTOR protein, in skin-derived-SS cells. Read More

Semin Hematol 2018 Oct 28;55(4):242-247. Epub 2018 May 28.

Department of Haematology and Central Haematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland; Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

Myelodysplastic syndromes (MDS) and associated diseases, like chronic myelomonocytic leukemias (CMML), are heterogeneous, clonal disorders affecting the hematopoietic stem cells. They are characterized by dysplasia and a propensity to evolve toward acute myeloid leukemia. Systemic inflammatory and autoimmune manifestations (SIAMs) occur with a prevalence of 10% to 20% in myeloid malignancies, but the underlying pathogenetic mechanisms remain obscure. Read More

Lancet Haematol 2018 Dec;5(12):e618-e627

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: The combination of chemotherapy and ponatinib in Philadelphia chromosome-positive acute lymphoblastic leukaemia has the potential to be a new standard of care for the disease; however, long-term efficacy and safety data are needed. Our aim was to evaluate the long-term efficacy and safety of this regimen in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia in this ongoing phase 2 trial.

Methods: In our single-centre, phase 2, single-arm trial in the USA, adult patients with previously untreated Philadelphia chromosome-positive acute lymphoblastic leukaemia were sequentially enrolled. Read More

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, Vermont.

The RUNX1 transcription factor has recently been shown to be obligatory for normal development. RUNX1 controls the expression of genes essential for proper development in many cell lineages and tissues including blood, bone, cartilage, hair follicles, and mammary glands. Compromised RUNX1 regulation is associated with many cancers. Read More

J Oncol Pharm Pract 2018 Dec 4:1078155218816768. Epub 2018 Dec 4.

1 Division of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Hyogo, Japan.

A 69-year-old woman who had been diagnosed with unresectable papillary thyroid cancer was referred to our hospital. We initially treated her with sorafenib, but she subsequently developed erythema multiforme, which was suspected to be a drug rush due to sorafenib; therefore, sorafenib was discontinued. At the time of discontinuation, immature blast cells were detected in her peripheral blood. Read More

Cutis 2018 Oct;102(4):266;271;272

Department of Clinical Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; ClearlyDerm, Boca Raton, Florida, USA.

Leukemia cutis (LC) is a rare neoplastic infiltration of the skin or subcutaneous tissue by leukemic cells. Because it correlates with sites of additional extramedullary involvement, it typically portends a poor prognosis. Although most cases of LC present concurrently with bone marrow infiltration, skin findings may precede systemic involvement in some cases; thus, early detection by dermatologists is essential. Read More

Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Di.S.Sal. Section of Dermatology, University of Genoa, San Martino Polyclinic Hospital, Genoa, Italy.

In recent years, dermatologic manifestations in oncohematologic patients have become more common. The aim of our study was to determine the incidence and heterogeneity of skin manifestations in patients followed at our Hematology Department. This observational monocentrical study was conducted on 60 patients. Read More

Front Pharmacol 2018 13;9:1279. Epub 2018 Nov 13.

Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.

Cutaneous manifestations in hematologic malignancies, especially in leukemia, are not common and may be very variable. Here we report a very unusual case of a patient (female, 70 years old) who was admitted to the hospital in 2016 because of skin lesions on the face, the trunk of the body and the extremities. She had a history of breast cancer in the year 2004 (pT1b, pN0, cM0, L0, V0, R0) which had been resected and treated with adjuvant radiation and chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracile) as well as psoriasis treated with methotrexate and cyclosporine. Read More

Toxicol In Vitro 2019 Mar 17;55:24-32. Epub 2018 Nov 17.

Immunology Microbiology Lab, Department of Human Physiology, Tripura University, Suryamaninagar, 799102 Agartala, Tripura, India. Electronic address:

The natural anti-cancer agent bromelain is found to be beneficial for either single or multi-targeted therapy in gastric and skin carcinoma, by inhibiting cancer cell growth. Importantly, the presence of peroxidase enhances its biological efficiency. We have now evaluated a panel of cancer cell lines with bromelain in presence or absence of peroxidase to identify that the combination has higher apoptosis inducing potential in all those cell lines. Read More

J Dermatol 2019 Jan 19;46(1):65-69. Epub 2018 Nov 19.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

We report the case of an 88-year-old Japanese man with erythrodermic involvement of T-cell prolymphocytic leukemia (T-PLL). He had a history of pharyngeal diffuse large B-cell lymphoma successfully treated with polychemotherapy including cyclophosphamide and epirubicin, 6 years before the current illness. He presented with numerous reddish, coalescing, flat-topped papules on the trunk and extremities, sparing the skin folds of the abdomen, the features of which mimicked those of papuloerythroderma. Read More

Toxicology 2019 Jan 13;411:93-100. Epub 2018 Nov 13.

The Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki, 303-0043, Japan; Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan. Electronic address:

Recent studies have shown that the estrogen receptor α (ERα), but not ERβ, is involved in the proinflammatory and propruritic responses in cutaneous allergy. In addition, results from our recent study showed that while oral administration of the rather ERβ-selective agonist bisphenol A exacerbated the respiratory allergic inflammation, the potential inflammatory reaction in the skin was decreased after administration of bisphenol A. This study aimed to elucidate whether ERα and ERβ are involved in the progression of an allergic airway inflammation. Read More

J Dermatol 2019 Feb 16;46(2):95-102. Epub 2018 Nov 16.

Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The relationship between psoriasis and cancer has not yet been established. The aim of this study was to evaluate the association of psoriasis with certain cancers using national statistics. All patients with psoriasis (n = 892 089; 51. Read More

BMC Cancer 2018 Nov 15;18(1):1117. Epub 2018 Nov 15.

DIMES (Department of Experimental, Diagnostic, and Specialty Medicine), Institute of Hematology "L. and A. Seragnoli", University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

Background: Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape of innovative compounds, inotuzumab ozogamicin (IO) is a promising drug, whose mechanism of action relies on the killing of CD22 positive leukemic cells, through the delivery, after cell binding, of a molecule of calicheamicin.

Case Presentation: We report two cases of CD22 positive relapsed EM-ALL treated with IO, obtained as compassionate use. Read More