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    Ibrutinib-Induced Neutrophilic Dermatosis.
    Am J Dermatopathol 2018 Mar;40(3):198-200
    Département d'Hématologie, Institut Gustave Roussy, Villejuif, France.
    We report the case of a 64-year-old woman treated with ibrutinib for a chronic lymphocytic leukemia with 17p deletion, who developed several erythematous, painful, and papulo-nodular skin lesions in the limbs, neck, and face. The skin biopsy was consistent with the diagnosis of neutrophilic dermatosis. Rechallenge with ibrutinib at full dose was followed by the recurrence of the same skin lesions, strongly suggesting a direct relationship. Read More

    Eccrine squamous syringometaplasia in an allogenic stem cell transplant patient undergoing chemotherapy.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    University of South Florida, Department of Dermatology and Cutaneous Surgery, Tampa, Florida.
    Eccrine squamous syringometaplasia (ESS) is a rare finding defined as metaplastic change of the cuboidal epithelial cells of eccrine glands into two or more layers of squamous epithelial cells. We present a patient who developed ESS after induction of CLAG chemotherapy [2-Chlorodeoxyadenosine (2-CdA) with cytarabine (Ara-C) and (granulocyte-colony stimulating factor) G-CSF] for management of the blast crisis of his chronic myelogenous leukemia (CML). Our patient's ESS eruption presented with a variety of morphologies, thus multiple skin biopsies were taken to determine the possible diagnosis(es). Read More

    Erythrodermic Psoriasis in a Man with Monoclonal B-cell Lymphocytosis.
    Cureus 2017 Dec 11;9(12):e1936. Epub 2017 Dec 11.
    Department of Dermatology, University of California, San Diego.
    Erythroderma is characterized by erythema involving greater than 90% of the body surface area and may be caused by several etiologies, including erythrodermic psoriasis. Psoriasis is an autoimmune skin and systemic condition characterized by erythematous and scaly plaques. Monoclonal B-cell lymphocytosis is an asymptomatic hematological disorder diagnosed by elevated, small, clonal B-cell counts in the peripheral blood. Read More

    Mechanism of apoptosis induction associated with ERK1/2 upregulation via goniothalamin in melanoma cells.
    Exp Ther Med 2018 Mar 17;15(3):3052-3058. Epub 2018 Jan 17.
    Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
    The present study aimed to investigate the effect of goniothalamin on apoptosis induction in the A375 melanoma cell line. Melanoma is a type of skin cancer with increased prevalence and no potential standard treatment. Goniothalamin is a plant, bioactive styrly-lactone, which has various bioactivities including anti-microbial, anti-inflammatory and anti-cancer. Read More

    An unusual presentation of adult T-cell leukemia/lymphoma.
    Ecancermedicalscience 2018 23;12:801. Epub 2018 Jan 23.
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1-7-1 Sakamoto, 8528501 Nagasaki-shi, Nagasaki, Japan.
    Adult T-cell Leukemia/Lymphoma (ATL) is a rare disease, related to human T-lymphotropic virus-1 (HTLV-1) and presented mainly in adulthood by generalised lymphadenopathy, hepatosplenomegaly, skin lesions and hypercalcaemia, with rare gastrointestinal and/or oral manifestations. We reported this case to raise awareness and demonstrate the therapeutic challenges of this rare disease. A 49-year-old Japanese female presented with skin papules on both forearms, painful mouth ulcers and multiple neck swellings since early February 2017. Read More

    Iris juvenile xanthogranuloma in an infant - spontaneous hyphema and secondary glaucoma.
    Rom J Ophthalmol 2017 Jul-Sep;61(3):229-236
    Opthalmology Clinic, "Sf. Spiridon" University Hospital, Iași, Romania.
    Juvenile xanthogranuloma (JXG) is a benign histiocytic skin disorder mainly encountered during infancy and childhood. Although with multiple potential localizations, less than 1% of the cases exhibit ocular manifestations. Some of these might lead to serious complications, specifically, secondary glaucoma that can result in severe and blinding eye disease. Read More

    Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases.
    Mod Pathol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center, and Jackson Memorial Hospitals, Miami, FL, USA.
    Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enriched for immigrants from human T-cell lymphotropic virus type 1 endemic areas, we have identified that a subset of adult T-cell leukemia/lymphoma, in the absence of human T-cell lymphotropic virus type 1 identification, are indistinguishable from other more common T-cell neoplasms. We retrospectively gathered serology results for anti-human T-cell lymphotropic virus type 1/2 antibody in patients diagnosed with T-cell neoplasms at our institution. Read More

    T-Lymphoblastic Leukemia/Lymphoma With Annular Skin Rash and Epidermotropism.
    Am J Dermatopathol 2018 Feb 7. Epub 2018 Feb 7.
    Departments of Pathology.
    Leukemia cutis is uncommon in patients with acute lymphoblastic leukemia. It typically presents with dermal papules or subcutaneous nodules, with no epidermal or upper papillary dermal involvement on histopathology. We present an unusual clinical presentation of leukemia cutis, with annular plaques and epidermotropism. Read More

    Lipopolysaccharide interferes with the use of the human Cell Line Activation Test to determine the allergic potential of proteins.
    J Pharmacol Toxicol Methods 2018 Feb 10. Epub 2018 Feb 10.
    Department of Chemical and Energy Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan.
    It was believed that high molecular weight molecules including proteins cannot penetrate the skin. However, protein penetration through disrupted/ruptured skin has been reported recently, thus carrying the potential for inducing an allergic response. We used the human Cell Line Activation Test (h-CLAT), an in vitro skin sensitization test, to assess the allergic potential of proteins by measuring levels of CD86 and CD54 in the human monocytic leukemia cell line THP-1. Read More

    Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia.
    Pediatr Infect Dis J 2018 Feb 12. Epub 2018 Feb 12.
    Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital.
    Disseminated fusariosis is a fatal infection in immunocompromised hosts. However, the optimal antifungal treatment for disseminated fusariosis has not yet been established. We report a case of disseminated fusariosis after chemotherapy for acute lymphoblastic leukemia, presenting with multiple skin, lung, and kidney lesions and cerebrospinal fluid invasion. Read More

    A Phase I Dose-Escalation Study of Clofarabine in Patients with Relapsed or Refractory Low-Grade or Intermediate-Grade B-Cell or T-Cell Lymphoma.
    Oncologist 2018 Feb 7. Epub 2018 Feb 7.
    Yale University School of Medicine, New Haven, Connecticut, USA.
    Lessons Learned: Clofarabine can be active in relapsed and refractory lymphoid malignancies on a weekly dosing schedule.Responses were seen in patients with T-cell lymphomas, including cutaneous T-cell lymphoma, but not in patients with aggressive B-cell lymphomas.

    Background: Clofarabine is a second-generation purine nucleoside analog currently approved for the treatment of pediatric relapsed or refractory acute lymphoblastic leukemia. Read More

    Therapy-associated myelodysplastic syndrome with monosomy 7 arising in a Muir-Torre Syndrome patient carryingmutation.
    Mol Clin Oncol 2018 Feb 8;8(2):306-309. Epub 2017 Dec 8.
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
    Muir-Torre Syndrome (MTS) is a rare hereditary autosomal dominant cancer syndrome and is linked to hereditary non-polyposis colorectal carcinoma (Lynch Syndrome). Individuals develop various skin neoplasms in addition to colorectal, endometrial and upper gastrointestinal malignancies. Therapy-associated myelodysplastic syndrome (T-MDS) is an aggressive hematologic malignancy and is considered a pre-leukemic phase. Read More

    S-nitrosylation of cIAP1 switches cancer cell fate from TNFα/TNFR1-mediated cell survival to cell death.
    Cancer Res 2018 Feb 5. Epub 2018 Feb 5.
    UFR Sciences de Santé, EPHE-université de Bourgogne
    Tumor necrosis factor alpha (TNFα) is a prominent proinflammatory cytokine and a critical mediator for the development of many types of cancer such as breast, colon, prostate, cervical, skin, liver, and chronic lymphocytic leukemia. Binding of TNFα to TNFR1 can lead to divergent signaling pathways promoting predominantly NF-kB activation but also cell death. We report here that the nitric oxide donor glyceryl trinitrate (GTN) converts TNFα, generated from immune cells or cancer cells stimulated by chemotherapy, into a pro-death mediator in colon and mammary cancer cells. Read More

    Implications of zoonotic and vector-borne parasites to free-roaming cats in central Spain.
    Vet Parasitol 2018 Feb;251:125-130
    Animal Health Department, Veterinary Faculty, Universidad Complutense de Madrid, Spain. Electronic address:
    Cats are definitive hosts and reservoirs for several parasites, some of which are responsible for serious zoonotic diseases. We conducted a case-control study of data from a trap-neuter-return (TNR) programme (years 2014-2017) designed to examine the prevalence of zoonotic parasites in free-roaming cats living in urban areas of central Spain. In the animal population tested (n = 263), we detected a 29. Read More

    Pruritic arthropod bite-like papules in T-cell large granular lymphocytic leukaemia and chronic myelomonocytic leukaemia.
    Clin Exp Dermatol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    T-cell large granular lymphocytic leukaemia (T-LGLL) is a clinically indolent mature T-cell neoplasm characterized by a monoclonal population of CD3+ CD8+ cytotoxic T cells, which usually presents as neutropenia, anaemia and thrombocytopenia. Chronic myelomonocytic leukaemia (CMML) is a clonal haematopoietic disorder with features of both a myeloproliferative neoplasm and myelodysplastic syndrome (MDS). Patients with CMML exhibit a persistent peripheral blood monocytosis in addition to myelodysplastic features. Read More

    Mometasone furoate inhibits growth of acute leukemia cells in childhood by regulating PI3K signaling pathway.
    Hematology 2018 Feb 8:1-8. Epub 2018 Feb 8.
    a Department of Pediatrics , No. Four Hospital of Jinan , Jinan , Shandong 250000 , People's Republic of China.
    Objectives: Acute lymphoblastic leukemia (ALL) is the most common cancer before the age of 15 years, seriously endangering the health of children. The main treatment for Childhood ALL was pharmacotherapy. But these drugs have many side effects and some of them could develop drug resistance quickly. Read More

    Imatinib-induced diffuse hyperpigmentation of the oral mucosa, the skin, and the nails in a patient affected by chronic myeloid leukemia: report of a case and review of the literature.
    Int J Dermatol 2018 Feb 8. Epub 2018 Feb 8.
    Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Imatinib mesylate is a tyrosine-kinase inhibitor used as the first-line treatment in chronic myeloid leukemia patients, but it is also indicated for other hematological diseases and solid tumors. Imatinib treatment is often associated with hypopigmentation, but only a few cases of hyperpigmentation are described in literature.

    Methods: We are reporting the first case of imatinib-related hyperpigmentation involving the oral mucosa, skin, and nails in a patient affected by chronic myeloid leukemia and treated with imatinib since 2002. Read More

    Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells.
    Arthritis Res Ther 2018 Feb 7;20(1):23. Epub 2018 Feb 7.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Background: Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. A recent study demonstrated the transdifferentiation of T helper type 2 cell (Th2)-like regulatory T cells (Tregs) in SSc lesional skin through interleukin (IL)-33 produced by fibroblasts. Therefore, we investigated the role of Fli1 deficiency in dermal fibroblast-mediated transdifferentiation of Tregs. Read More

    Necrotizing fungal gingivitis in a patient with Acute Myelogenous Leukemia: visible yet obscure.
    J Oral Maxillofac Surg Med Pathol 2018 Jan 12;30(1):50-54. Epub 2017 Sep 12.
    Department of Leukemia, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas.
    Oral fungal infections present with atypical and varied manifestations, and distinguishing them from other entities including leukemic infiltration can be diagnostically challenging. In this report, we describe a 62 year old female with acute myeloid leukemia who presented, towards the end of her second treatment cycle of decitabine in a prolonged neutropenic state, with a month of painful, necrotic-appearing marginal gingival lesions. She was duly initiated on empiric broad spectrum antifungal treatment but did not show a clinical response with the appearance of new skin lesions concerning for progressive fungemia. Read More

    Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia.
    Oncoimmunology 2018 11;7(3):e1405204. Epub 2017 Dec 11.
    Department of Hematology, Respiratory Medicine and Oncology, Saga University School of Medicine, Saga, Japan.
    Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed to depletion of CCR4regulatory T cells. We previously showed that next generation sequencing enables precise analysis of the T cell receptor (TCR) repertoire, and we here used the technique to reveal the immunological dynamics in moga-treated ATL patients. Treatment with moga resulted in remarkable reduction or elimination of clonal cells, and enhanced reconstitution of non-tumor polyclonal CD4T cells and oligoclonal CD8T cells. Read More

    Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries.
    Lancet 2018 Jan 30. Epub 2018 Jan 30.
    Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
    Background: In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014.

    Methods: CONCORD-3 includes individual records for 37·5 million patients diagnosed with cancer during the 15-year period 2000-14. Read More

    Quantification of cancer risk in glomerulonephritis.
    BMC Nephrol 2018 02 2;19(1):27. Epub 2018 Feb 2.
    Department of Production, Research and Innovation, Region Zealand, Sorø, Denmark.
    Background: The association of increased cancer risk with glomerulonephritis (GN) is well known, but controversy exists concerning which types of GN are involved, and the size of the association. A national registry survey was performed to assess the size of this association, and the temporal relationship of cancer diagnosis to GN diagnosis.

    Methods: All patients with biopsy-proven GN between 1985 and 2015 in Denmark were extracted from The Danish Renal Biopsy Registry and the National Pathology Data Bank. Read More

    Phase 2 trial of a multivalent WT1 peptide vaccine (galinpepimut-S) in acute myeloid leukemia.
    Blood Adv 2018 Feb;2(3):224-234
    Immunology Laboratory Service, Department of Laboratory Medicine, and.
    A National Cancer Institute consensus study on prioritization of cancer antigens ranked the Wilms tumor 1 (WT1) protein as the top immunotherapy target in cancer. We previously reported a pilot study of a multivalent WT1 peptide vaccine (galinpepimut-S) in acute myeloid leukemia (AML) patients. We have now conducted a phase 2 study investigating this vaccine in adults with AML in first complete remission (CR1). Read More

    Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.
    Proc Natl Acad Sci U S A 2018 Feb 30;115(7):1582-1587. Epub 2018 Jan 30.
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425;
    Janus kinase 2 (JAK2) signal transduction is a critical mediator of the immune response. JAK2 is implicated in the onset of graft-versus-host disease (GVHD), which is a significant cause of transplant-related mortality after allogeneic hematopoietic cell transplantation (allo-HCT). Transfer of JAK2donor T cells to allogeneic recipients leads to attenuated GVHD yet maintains graft-versus-leukemia. Read More

    Hemorrhagic pericardial effusion as the debut of acquired hemophilia in a chronic lymphocytic leukemia patient: A case report, and a review of acquired hemophilia A-related hematological malignancies.
    Medicine (Baltimore) 2017 Nov;96(47):e8669
    Department of Hematology, Hospital Universitario de Salamanca-IBSAL, Salamanca.
    Background: Acquired hemophilia A (AHA) is a rare bleeding disease caused by autoantibodies against factor VIII. Spontaneous bleeding symptoms usually affect the skin and muscle, while pericardial effusion is an extremely rare manifestation. In the elderly, anticoagulant treatment is frequent and bleeding symptoms are usually associated with this. Read More

    Acute myeloid leukemia presenting as erythema nodosum: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8666
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Rationale: Erythema nodosum (EN), a type of septal panniculitis, could be a rare nonspecific cutaneous presentation of acute myeloid leukemia (AML).

    Patient Concerns: A 58-year-old Chinese female was admitted for a 4-week history of painful cutaneous lesions, accompanied by a sternal pain and fever. The lesions once resolved spontaneously but then recurred. Read More

    Lessons from an Outbreak of Varicella Infection in Pediatric Hemato-Oncology Patients.
    Pediatr Infect Dis J 2018 Jan 25. Epub 2018 Jan 25.
    Pediatric Hemato-Oncology Department, Pediatric Infectious Diseases Unit, and Department of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Immunocompromized patients exposed to varicella may experience significant morbidity and a 7% mortality rate. Management and outcome of an outbreak of varicella infection among hospitalized pediatric hemato-oncology patients using the guidelines of the American Academy of Pediatrics Committee on Infectious Diseases is presented.

    Patients And Methods: This retrospective study describes an outbreak of varicella infection between February 2011 and June 2011. Read More

    Cytogenetic/mutation profile of chronic lymphocytic leukemia/malignant melanoma collision tumors of the skin.
    Mol Cytogenet 2018 16;11. Epub 2018 Jan 16.
    1Molecular Medicine Laboratory, Hematology and Bone Marrow Transplantation Unit, University of Perugia, Hospital S. Maria della Misericordia, Piazzale Menghini n.9, 06132 Perugia, Italy.
    Background: Collision tumors are rare entities that consist of two histologically distinct tumor types arising in the same anatomic site. An association between chronic lymphocytic leukemia (CLL) and malignant melanoma (MM) has been already described. Up to now, they have been documented only at positive regional lymph nodes while we focused on collision tumor in a skin lesion. Read More

    Profile of Skin pH in Leukaemia's Children with Chemotherapy Treatments at Haji Adam Malik General Hospital, Medan.
    Open Access Maced J Med Sci 2017 Dec 5;5(7):945-947. Epub 2017 Dec 5.
    Haji Adam Malik General Hospital, Dermatology and Venereology, Medan, Indonesia.
    Background: One of the treatments for leukaemia is chemotherapy. Side effects and toxicity of this treatment can be seen on the skin, adnexal, and mucous membranes. They might increase potential hydrogen (pH) value on the skin surface, therefore, disrupting epidermal barrier defences. Read More

    T-cell papulosis associated with B-cell malignancy: a distinctive clinicopathologic entity.
    J Eur Acad Dermatol Venereol 2018 Jan 22. Epub 2018 Jan 22.
    Service de Dermatologie, Hôpital Robert Debré, Reims, France.
    Background: A distinctive eruption referred to as 'insect bite-like reaction' or 'eosinophilic dermatosis of haematological malignancy' has been described during the course of haematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear.

    Objectives: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. Read More

    Retrospective audit of patients referred for further treatment following Mohs surgery for non-melanoma skin cancer.
    Australas J Dermatol 2018 Jan 18. Epub 2018 Jan 18.
    Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    Background/objectives: To describe the characteristics, subsequent management and outcomes of patients referred for further management following Mohs micrographic surgery (MMS) for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

    Methods: Retrospective analysis of patients referred to a quaternary cancer centre from 2000 to 2015.

    Results: In total, 83 lesions in 82 patients were referred for further management; 52 (62%) were SCC and 80 (96%) were located in the head and neck. Read More

    The protective role of DOT1L in UV-induced melanomagenesis.
    Nat Commun 2018 01 17;9(1):259. Epub 2018 Jan 17.
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
    The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective role in ultraviolet radiation (UVR)-induced melanoma development. Specifically, the DOT1L gene is located in a frequently deleted region and undergoes somatic mutation in human melanoma. Read More

    Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms.
    J Eur Acad Dermatol Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma.

    Objective: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog.

    Methods: We treated seven cutaneous lymphoma patients with Mog. Read More

    [Disseminated fusariosis in patients with acute leukemia: a retrospective analysis of three cases].
    Rinsho Ketsueki 2017;58(12):2375-2379
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.
    We report three cases of fusariosis that occurred during the treatment of acute leukemia, during the past 5 years at our institution. Case 1: A 70-year-old male with relapsed and refractory acute lymphoblastic leukemia (ALL) developed fever and multiple nodular lesions in both the lungs. Blood culture that was subsequently obtained revealed Fusarium species. Read More

    Mastocytosis - pathogenesis, clinical manifestation and treatment.
    J Dtsch Dermatol Ges 2018 Jan;16(1):42-57
    Department of Dermatology, University Medical Center, Mainz, Germany.
    The term mastocytosis designates a group of rare disorders characterized by typical skin lesions, frequently associated episodes of anaphylaxis, and clinical symptoms related to the release of various mediators. Dermatologists/allergists are frequently the first to establish the diagnosis. The condition is based on clonal mast cell proliferation, usually in the skin or bone marrow and only rarely in the gastrointestinal tract or other tissues. Read More

    Comparison of EBV-positive Mucocutaneous Ulcer (EBVMCU) Associated with Treated Lymphoma or Methotrexate in Japan.
    Histopathology 2018 Jan 4. Epub 2018 Jan 4.
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital.
    Aims: The present study compared treated lymphoma-associated EBV-positive mucocutaneous ulcer (EBVMCU) and methotrexate (MTX)-associated EBVMCU.

    Methods And Results: Of a series of 15 Japanese patients (11 women, 4 men; median age 74 years, range 35-84 years). 7 received MTX for autoimmune disease and 8 developed EBVMCU after treatment of malignant lymphoma (diffuse large B-cell lymphoma [n=4] without EBV association, adult T-cell leukaemia/lymphoma [n=2], angioimmunoblastic T-cell lymphoma [n=1], and follicular lymphoma [n=1]). Read More

    Incidence of Fanconi anaemia in phenotypically normal aplastic anaemia patients in West Bengal.
    Hematology 2018 Jan 7:1-8. Epub 2018 Jan 7.
    a Vivekananda Institute of Medical Sciences , Kolkata , India.
    Objectives: Fanconi anaemia (FA) is a rare inherited bone marrow failure and autosomal recessive blood disorder. FA patients have a higher risk of cancer, including acute myeloid leukaemia and squamous cell carcinoma. Maximum, but not all, affected individuals have one or more somatic abnormalities, including skin, skeletal, genitourinary, gastrointestinal, cardiac and neurological anomalies, etc. Read More

    The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow.
    PLoS One 2018 5;13(1):e0190525. Epub 2018 Jan 5.
    Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland.
    We studied three FLT3 ITD acute myeloid leukemia (AML) patients who relapsed after allogeneic haematopoietic stem cell transplantation (alloHSCT) and received multikinase inhibitor (MKI) sorafenib as part of salvage therapy. MKI was given to block the effect of FLT3 ITD mutation which powers proliferation of blast cells. However, the known facts that sorafenib is more effective in patents post alloHSCT suggested that this MKI can augment the immune system surveillance on leukaemia. Read More

    Favorable immune signature in CLL patients, defined by antigen-specific T-cell responses, might prevent second skin cancers.
    Leuk Lymphoma 2018 Jan 3:1-10. Epub 2018 Jan 3.
    b Department of Immunology , Institute for Cell Biology, University of Tübingen , Tübingen , Germany.
    The course of chronic lymphocytic leukemia (CLL), inducing an immunosuppressed state that also affects T cells as central components of adaptive immunity, predisposes patients to develop second malignancies with skin cancer being the most common. Recently, we found that prevalence of memory T cells with specificity for CLL-associated antigens defined by mass spectrometry-based immunopeptidome analysis correlated with a significant survival benefit. Here, we analyzed our CLL patient cohort for second skin (pre)malignancies and found a significantly lower incidence of skin cancer in the patients showing immune responses to CLL-associated antigens. Read More

    Kaposi Sarcoma After Allogeneic Hematopoietic Stem Cell Transplant: A Rare Complication.
    Exp Clin Transplant 2018 Jan 2. Epub 2018 Jan 2.
    From the Hematology Research Center, Department of Hematology, Medical Oncology and Stem Cell Transplantation; Shiraz University of Medical Sciences, Shiraz, Iran.
    Kaposi sarcoma is a multicentric angioproliferative neoplasm of lymphatic endothelium-derived cells. Although this malignancy is relatively frequent after solid-organ transplant, it is extremely rare after bone marrow transplantation. Allogeneic stem cell transplantation is associated with severe prolonged immunosuppression; however, a few cases of Kaposi sarcoma after hematopoietic stem cell transplant were previously reported. Read More

    Marinobufagin, a molecule from poisonous frogs, causes biochemical, morphological and cell cycle changes in human neoplasms and vegetal cells.
    Toxicol Lett 2018 Mar 26;285:121-131. Epub 2017 Dec 26.
    Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil; Department of Biophysics and Physiology, Laboratory of Experimental Cancerology, Federal University of Piauí, Teresina, Brazil. Electronic address:
    Skin toad secretion present physiologically active molecules to protect them against microorganisms, predators and infections. This work detailed the antiproliferative action of marinobufagin on tumor and normal lines, investigate its mechanism on HL-60 leukemia cells and its toxic effects on Allium cepa meristematic cells. Initially, cytotoxic action was assessed by colorimetric assays. Read More

    Risk Factors for Invasive Fungal Infection among Thai Oncologic Patients with Febrile Neutropenia and Cutaneous Presentation: A 5-Year Retrospective Study in Southern Thailand
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3239-3243. Epub 2017 Dec 29.
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand. Email:
    Background: Febrile neutropenia (FNP) is a condition defined by fever and neutropenia. There are current only limited data on related cutaneous manifestations. This study aimed to assess cutaneous lesions and their etiologies in a Thai group of FNP patients. Read More

    2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells.
    Oncol Rep 2018 Mar 20;39(3):1331-1337. Epub 2017 Dec 20.
    Department of Biochemistry, China Medical University, Taichung 404, Taiwan, R.O.C.
    The present study aimed to investigate the biological effects of the new compound 2‑phenyl‑4‑quinolone (YT‑1) on human leukemia cells. Cell viability was determined by propidium iodide (PI) exclusion method followed by flow cytometry. Our results showed that YT‑1 inhibited the cell viability and resulted in morphologic changes to the U937, HL‑60 and K562 cells, respectively. Read More

    : an emerging multidrug-resistant opportunistic pathogen in the immunocompromised host.
    BMJ Case Rep 2017 Dec 20;2017. Epub 2017 Dec 20.
    Dermatology and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    is a multidrug-resistant opportunistic pathogen with increasing prevalence and high morbidity and mortality. In addition to its classic association with pulmonary infections,can cause skin and soft tissue infections with varying clinical presentations. We describe the case of a man in his 30s with B-cell acute lymphoblastic leukaemia who presented with a solitary patch of faint but tender purpura found to have rapidly progressiveinfection diagnosed on skin biopsy. Read More

    Cutaneous myeloid sarcoma associated with chronic myeloid leukemia.
    An Bras Dermatol 2017 ;92(5 Suppl 1):50-52
    Department of Pathology, Universidade Federal Fluminense (UFF), Niterói RJ, Brazil.
    Myeloid sarcoma is an extramedullary tumor of malignant myeloid cells often associated with acute myeloid leukemia, chronic myeloproliferative disorders and myelodysplastic syndromes. The skin is one of the most commonly affected sites. We report a rare case of cutaneous myeloid sarcoma associated with chronic myeloid leukemia. Read More

    Nilotinib after imatinib first-line: a real-life longitudinal cohort of patients with chronic myeloid leukaemia in chronic phase.
    Br J Haematol 2018 02 19;180(3):356-364. Epub 2017 Dec 19.
    Fi LMC group, Institut Bergonié, Bordeaux, France.
    This prospective, observational study enrolled 150 adult patients with chronic myeloid leukaemia (CML) in chronic phase (CP) treated with nilotinib as second-line after imatinib, in a real life setting in France. Two-thirds of patients switched to nilotinib treatment due to lack of imatinib efficacy. Of 146 evaluable patients, 16 (11·0%) (95% confidence interval: 6·4-17·2%) achieved uMR, defined as undetectable molecular disease in cDNA with MRsensitivity (≥10 000 ABL1 transcripts) at 18 months and confirmed at 24 months (primary endpoint). Read More

    A transient cutaneous relapse of AML M1 in hematological remission: a case report.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):109-111
    Department of Dermatology, University of Trieste, Trieste, Italy.
    Leukemia cutis (LC) is described as cutaneous infiltration by neoplastic leukocytes into the epidermidis, dermis, or subcutis, resulting in clinically various skin lesions. When the infiltrate is characterized by neoplastic granulocytic precursors, LC is defined as granulocytic sarcoma. Multiple, erythematous, and infiltrated papules and nodules localized on the legs, arms, and trunk are the most common clinical presentation. Read More

    Copper-associated hepatitis in a patient with chronic myeloid leukemia following hematopoietic stem cell transplantation: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e9041
    aDivision of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital, TaoyuanbDepartment of Nursing, Chang Gung Memorial Hospital, TaoyuancDivisions of Hematology/Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, TaoyuandDivision of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, TaoyuaneLiver Research Center, Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Linkou, Taiwan.
    Rationale: We report a complicated case of cholestatic hepatitis with suspected autoimmune hemolytic anemia (AIHA) and copper toxicity syndrome after HSCT and donor lymphocyte infusion (DLI).

    Patient Concerns: A 19-year-1-month-old girl presented with a history of CML. She underwent matched unrelated donor HSCT and donor lymphocyte infusion subsequently. Read More

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