9,794 results match your criteria Leukemia Cutis


Frequency and Molecular Identification of Species among Immunocompromised Patients Referred to Hospitals, Central Iran, 2015-16.

Iran J Parasitol 2020 Jan-Mar;15(1):31-39

Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The purpose of this study was to determine the prevalence and genotype of spp. in different groups of immunocompromised patients admitted to the referral hospitals in center of Iran during 2015-2016.

Methods: This cross-sectional study was conducted on 346 immunocompromised patients (HIV/AIDS, Lymphoma, Leukemia and organ transplants) in referred hospitals from central parts of Iran including Isfahan, Markazi, Yazd and Chaharmahale Bakhtiari provinces. Read More

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Erythrodermic psoriasis versus skin lesions in chronic lymphocytic leukaemia.

Postepy Dermatol Alergol 2020 Apr 6;37(2):277-279. Epub 2020 May 6.

Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland.

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http://dx.doi.org/10.5114/ada.2020.94849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262804PMC

Diagnostic challenge of aleukemic leukemia cutis preceding acute myelogenous leukemia: A case report.

SAGE Open Med Case Rep 2020 6;8:2050313X20919638. Epub 2020 May 6.

Division of Dermatology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Aleukemic leukemia cutis is a rare condition in which malignant white cells invade the skin before they appear in the peripheral blood or bone marrow. It is often associated with a poor prognosis. The condition presents a diagnostic challenge as its manifestations are quite variable terms of lesion type. Read More

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http://dx.doi.org/10.1177/2050313X20919638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233898PMC

Anaphylaxis related to disinfection with chlorhexidine in a teenager treated for cancer.

J Oncol Pharm Pract 2020 May 31:1078155220925531. Epub 2020 May 31.

Division of Pediatric Haemato-Oncology and Stem Cell Transplantation, Department of Pediatrics, Ghent University Hospital, Ghent, Belgium.

Introduction: Literature shows upcoming allergy to chlorhexidine due to the widespread use of the disinfectant within and outside surgical settings. Only a few case reports have been published regarding the use of topical chlorhexidine disinfectant outside surgery and only a minority of these within the pediatric population.

Case Report: We present a case-report of a teenager, treated for acute lymphoblastic leukemia who developed an anaphylactic shock after repeated chlorhexidine use for skin disinfection at the insertion of a central venous catheter during his chemotherapy treatment. Read More

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http://dx.doi.org/10.1177/1078155220925531DOI Listing

Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.

Int J Mol Sci 2020 May 26;21(11). Epub 2020 May 26.

Faculty of Medicine, University of Ulm, 89081 Ulm, Germany.

The deubiquitination of histone H2A on lysine 119 by 2A-DUB/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells. Based on our finding that MYSM1 colocalizes with γH2AX foci in human peripheral blood mononuclear cells, leukemia cells, and melanoma cells upon induction of DNA double-strand breaks with topoisomerase inhibitor etoposide, we applied a mass spectrometry-based proteomics approach to identify novel 2A-DUB/MYSM1 interaction partners in DNA-damage responses. Differential display of MYSM1 binding proteins significantly enriched after exposure of 293T cells to etoposide revealed an interacting network of proteins involved in DNA damage and replication, including factors associated with poor melanoma outcome. Read More

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http://dx.doi.org/10.3390/ijms21113762DOI Listing

Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China.

Authors:
Liu Hui

Biomed Res Int 2020 6;2020:9043012. Epub 2020 May 6.

Department of Clinical Immunology, Dalian Medical University, Dalian 116044, China.

Objective: To quantify the change in risk and aging factors with a two time point analysis for major cancers to assess supportive strategies.

Methods: The 2004 and 2015 mortality statistics in China were accessed. The standardized mortality rates of the two periods were used to calculate the ratio of change (RC) value to assess the risk of death associated with time (social development with time) for cancers. Read More

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http://dx.doi.org/10.1155/2020/9043012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229547PMC

Regional Injection of CAR-T Cells for the Treatment of Refractory and Recurrent Diffuse Large B Cell Lymphoma: A Case Report.

Front Cell Dev Biol 2020 8;8:333. Epub 2020 May 8.

Puyang Oilfield General Hospital, Puyang, China.

Background: Lymphoma is a common hematological malignancy with many subtypes and considerable heterogeneity. Traditional treatments include chemotherapy, radiotherapy, and surgery. Patients with relapsed, refractory or advanced stage lymphoma have a dismal prognosis. Read More

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http://dx.doi.org/10.3389/fcell.2020.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225683PMC

Dactinomycin in acute myeloid leukemia with NPM1 mutations.

Eur J Haematol 2020 May 25. Epub 2020 May 25.

Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

Objectives: Complete responses have been observed in NPM1-mutated AML patients with dactinomycin, a nucleolar stress-inducing drug. Here, we report a single-center experience of compassionate use of dactinomycin in untreated or relapsed/ refractory NPM1-mutated AML.

Methods: From September 2015 to February 2019, 26 adult patients with NPM1-mutated AML received dactinomycin in different situations: front-line treatment in 4 unfit patients (16%); morphologic (n = 16, 62%), molecular relapses (n = 4, 16%), refractory disease (n = 1, 13%), or postremission therapy in second complete response (n = 1, 13%). Read More

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http://dx.doi.org/10.1111/ejh.13438DOI Listing

Leukemia cutis in a medical center in southern Taiwan: A retrospective study of 42 patients.

J Formos Med Assoc 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Department of Cosmetic Applications and Management, Yuh Ying Junior College of Healthcare and Management, Kaohsiung, Taiwan. Electronic address:

Background/purpose: Leukemia cutis (LC), by definition, is the infiltration of neoplastic leukocytes in the skin. The overall incidence of LC is rare. We aimed to investigate the association between clinical characteristics, classifications and prognosis among different types of LC in Taiwan. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.04.025DOI Listing

Biotransformation of arsenic and toxicological implication of arsenic metabolites.

Authors:
Seishiro Hirano

Arch Toxicol 2020 May 20. Epub 2020 May 20.

Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan.

Arsenic is a well-known environmental carcinogen and chronic exposure to arsenic through drinking water has been reported to cause skin, bladder and lung cancers, with arsenic metabolites being implicated in the pathogenesis. In contrast, arsenic trioxide (AsO) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, in which the binding of arsenite (iAs) to promyelocytic leukemia (PML) protein is the proposed initial step. These findings on the two-edged sword characteristics of arsenic suggest that after entry into cells, arsenic reaches the nucleus and triggers various nuclear events. Read More

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http://dx.doi.org/10.1007/s00204-020-02772-9DOI Listing

Robust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma.

Blood Adv 2020 May;4(10):2180-2191

Department of Hematology and Oncology and.

Skin-related adverse events (AEs) occur frequently in adult T-cell leukemia-lymphoma (ATL) patients treated with mogamulizumab, a humanized anti-CCR4 monoclonal antibody. This study was undertaken to elucidate the mechanisms of mogamulizumab-induced skin-related AEs. We analyzed the T-cell receptor β chain repertoire in ATL patients' peripheral blood mononuclear cells (PBMCs) before and after mogamulizumab. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252545PMC

Leukemia Cutis.

Indian J Hematol Blood Transfus 2020 Apr 10;36(2):441. Epub 2019 Sep 10.

3Division of Hematology and Bone Marrow Transplant, Max Super-Specialty Hospital, Saket, New Delhi, India.

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http://dx.doi.org/10.1007/s12288-019-01184-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229057PMC

Genital Sweet's Syndrome in a patient with Acute Myelogenous Leukemia.

Urol Case Rep 2020 Sep 3;32:101235. Epub 2020 May 3.

Brooke Army Medical Center, 3551 Roger Brooke Dr, Ft Sam Houston, TX, 78234, USA.

A 71 year old male presented to the emergency room for evaluation of acute erythema, edema and pain of the penis and scrotum. There was initial concern for Fournier's gangrene, however labs were unremarkable and vital signs were stable. He did not improve with antibiotics. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217983PMC
September 2020

Metalworking fluids and cancer mortality in a US autoworker cohort (1941-2015).

Scand J Work Environ Health 2020 May 14. Epub 2020 May 14.

Environmental Health Science, School of Public Health, University of California, Berkeley, 2121 Berkeley Way #5302, Berkeley, CA 94720-7360, USA.

Objectives This report describes the extended follow-up (1941-2015) of a cohort of 38 649 automobile manufacturing workers with potential exposure to metalworking fluids (MWF). The outcomes of interest were mortality from cancers of the esophagus, stomach, intestine, rectum, bladder, liver, pancreas, larynx, lung, skin, prostate, brain, and female breast, as well as leukemia. This report includes 5472 deaths from cancer, more than ten times the numbers of deaths in our last summary report published 20 years ago. Read More

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http://dx.doi.org/10.5271/sjweh.3898DOI Listing

Successful treatment of acute B lymphoblastic leukemia relapse in the skin and testicle by anti-CD19 CAR-T with IL-6 knocking down: a case report.

Biomark Res 2020 6;8:12. Epub 2020 May 6.

2Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Shizi street 188, Suzhou, 215006 China.

Background: Extramedullary relapse is an important cause of treatment failure among patients with acute lymphoblastic leukemia (ALL). This type of relapse is commonly observed in the central nervous system, while it is rare in the testicles and skin. Chimeric antigen receptor-modified T cell (CAR-T) therapy targeting CD19 has shown to be a beneficial treatment approach for relapsed/refractory B cell acute lymphoblasticleukemia (r/r B-ALL). Read More

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http://dx.doi.org/10.1186/s40364-020-00193-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204010PMC

Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases.

Blood Adv 2020 May;4(9):2084-2094

Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University, New York, NY.

We examined the risk of subsequent neoplasms (SNs) and late mortality in children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases (NMDs). We included 6028 patients (median age, 6 years; interquartile range, 1-11; range, <1 to 20) from the Center for International Blood and Marrow Transplant Research (1995-2012) registry. Standardized mortality ratios (SMRs) in 2-year survivors and standardized incidence ratios (SIRs) were calculated to compare mortality and SN rates with expected rates in the general population. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019000839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218429PMC

Collagen - an important fish allergen for improved diagnosis.

J Allergy Clin Immunol Pract 2020 May 7. Epub 2020 May 7.

College of Public Health, Medical and Veterinary Sciences, Australian Institute of Tropical Health and Medicine, Molecular Allergy Research Laboratory, James Cook University, Townsville, Queensland, Australia. Electronic address:

Background: Fish collagen is widely used in medicine, cosmetics and the food industry. However, its clinical relevance as an allergen is not fully appreciated. This is likely due to collagen insolubility in neutral aqueous solution, leading to low abundance in commercially available in vitro and skin prick tests for fish allergy. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.04.063DOI Listing

Subcutaneous Masses as an Unusual Manifestation of Relapse in a Case of Atypical Chronic Lymphocytic Leukemia with Prolymphocytoid Transformation and Complex Karyotype: A Diagnostic Dilemma and Treatment Challenge.

Am J Case Rep 2020 May 10;21:e920411. Epub 2020 May 10.

Department of Hematology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Most patients with chronic lymphocytic leukemia (CLL) are asymptomatic at diagnosis, but 10% present with B symptoms. Most patients have palpable lymphadenopathy, while 20-50% of the patients have hepatosplenomegaly. Cutaneous infiltrations in patients with CLL can be localized or generalized in the form of erythematous papules, plaques, nodules and, ulceration, which is uncommon. Read More

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http://dx.doi.org/10.12659/AJCR.920411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244225PMC

Occurrence of lymphoplasmacytic lymphoma in a chronic myeloid leukemia patient following long-term treatment with tyrosine kinase inhibitors: A case report.

Medicine (Baltimore) 2020 May;99(19):e19962

Department of Internal Medicine.

Introduction: After tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 were introduced for the treatment of chronic myeloid leukemia, clinical outcomes have improved dramatically. However, together with the increase in the survival rate, a more frequent occurrence of secondary malignancies has been observed as well. TKIs have been demonstrated to be a risk factor of malignancies such as non-Hodgkin lymphoma, prostate cancer, and skin cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000019962DOI Listing

Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report.

Diagn Cytopathol 2020 May 6. Epub 2020 May 6.

Department of Hematology, Peking University First Hospital, Beijing, China.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy arising from plasmacytoid dendritic cell precursors. The disease typically manifests in the skin, but it also evolves into a leukemic phase or can be complicated by other myeloid malignancies, especially myelomonocytic tumors. The association between these neoplasms is not fully elucidated. Read More

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http://dx.doi.org/10.1002/dc.24463DOI Listing

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716.

Acta Derm Venereol 2020 May 6. Epub 2020 May 6.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, L8S4L8 Hamilton, Canada. E-mail:

To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716, and anti-IL-31 receptor α antibody in human epidermal keratinocytes and human dermal fibroblasts in vitro. In human epidermal keratinocytes, OSM significantly induced STAT3 or STAT1 phosphorylation and synergized with IL-13 or IL-4 in elevating MCP-1. In human dermal fibroblasts, OSM results were similar, and leukemia inhibitory factor or IL-31 minimally activated STAT3 but not MCP-1. Read More

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http://dx.doi.org/10.2340/00015555-3505DOI Listing

Tricin Isolated from Enzyme-Treated Extract Inhibits IgE-Mediated Allergic Reactions in RBL-2H3 Cells by Targeting the Lyn/Syk Pathway.

Molecules 2020 Apr 29;25(9). Epub 2020 Apr 29.

Department of Food Science and Technology, Keimyung University, Daegu 42601, Korea.

Tricin, a flavone present in rice bran, is confirmed as the major efficacious compound present in the enzyme-treated extract (ETZL), which protects against UVB-induced skin-aging. However, the suppressive mechanism of tricin on allergic responses remains unknown. The present study, therefore, aimed to determine the mechanisms of tricin and ETZL on mast cell degranulation in IgE-activated rat basophilic leukemia cell line (RBL-2H3) cells. Read More

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http://dx.doi.org/10.3390/molecules25092084DOI Listing

Synchronous high-grade bladder carcinoma associated with chronic lymphocytic leukemia: A rare entity in Indian literature.

J Cancer Res Ther 2020 Jan-Mar;16(1):180-182

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is one of the common lymphoproliferative disorders with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this emergence of secondary malignancy. Breast, brain, skin and prostate tumors have been reported as usual coincident malignancies of CLL, while in occasional cases CLL may occur with malignancies of other solid organs, such as skin, lung, heart, and prostate. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_642_16DOI Listing

Malignancy Prevalence in Waitlisted Potential Kidney Transplant Recipients Is Very Low Relative to Patients After Kidney Transplantation.

Transplant Proc 2020 Apr 30. Epub 2020 Apr 30.

Department of Nephrology, Dialysis and Internal Disease, Medical University of Warsaw, Poland. Electronic address:

Kidney transplantation improves quality of life, prolongs survival, and is cost-effective, but bears some serious complications including malignancy. The aim of this study was to assess the prevalence of malignancy in dialyzed patients on the waiting list and in kidney allograft recipients. The cross-sectional study was conducted in 50 prevalent patients on the waiting list and 300 kidney allograft recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.119DOI Listing

Acquired reactive perforating collagenosis in association with prostate adenocarcinoma, chronic lymphocytic leukemia, and Graves' disease.

An Bras Dermatol 2020 May - Jun;95(3):336-339. Epub 2020 Apr 18.

Department of Dermatology and Venerology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Acquired reactive perforating collagenosis is a rare skin disorder characterized by the presence of umbilicated pruritic papules and nodules. Transepidermal elimination of altered and perforating bundles of basophilic collagen from the epidermis is a characteristic histologic feature of acquired reactive perforating collagenosis. Along with its well-known association with systemic diseases such as diabetes mellitus, chronic renal failure, and dermatomyositis, there are reports of acquired reactive perforating collagenosis being associated with malignancies. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253912PMC

Widespread nodules and papules in a patient with chronic myelomonocytic leukemia.

Int J Dermatol 2020 May 2. Epub 2020 May 2.

Westmead Medical School, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1111/ijd.14899DOI Listing

Lifestyle among long-term survivors of cancers in young adulthood.

Support Care Cancer 2020 May 1. Epub 2020 May 1.

Department of Oncology, National Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, Oslo, Norway.

Purpose: To investigate lifestyle in a population-based sample of long-term (≥ 5 years since diagnosis) young adult cancer survivors (YACSs), and explore factors associated with not meeting the lifestyle guidelines for physical activity (PA), body mass index (BMI), and smoking.

Methods: YACSs (n = 3558) diagnosed with breast cancer (BC), colorectal cancer (CRC), non-Hodgkin lymphoma (NHL), acute lymphoblastic leukemia (ALL), or localized malignant melanoma (MM) between the ages of 19 and 39 years and treated between 1985 and 2009 were invited to complete a mailed questionnaire. Survivors of localized MM treated with limited skin surgery served as a reference group for treatment burden. Read More

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http://dx.doi.org/10.1007/s00520-020-05445-6DOI Listing

Chimeric antigen receptor-modified T-cell therapy for bone marrow and skin relapse Philadelphia chromosome-like acute lymphoblastic leukemia: A case report.

Medicine (Baltimore) 2020 May;99(18):e18639

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Rationale: Chimeric antigen receptor-modified T-cell (CART) therapy has revolutionized the treatment of patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). However, the capacity of CART therapy has not yet been fully elucidated.

Patient Concerns: An 18-year-old Chinese male patient presented with multiple firm masses on the skin all over his body following regular chemotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000018639DOI Listing

Blastic Plasmacytoid Dendritic Cell Neoplasm in Children.

Hematol Oncol Clin North Am 2020 Jun 9;34(3):601-612. Epub 2020 Mar 9.

Pediatric Hematology, Oncology and Hematopoietic Stem Cell Transplantation, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematological malignancy, derived from plasmacytoid dendritic cells. It mainly occurs in older adults, but has been reported across all age groups. Most patients present with skin lesions with or without marrow involvement and leukemic dissemination. Read More

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http://dx.doi.org/10.1016/j.hoc.2020.01.008DOI Listing

Blastic Plasmacytoid Dendritic Cell Neoplasm: The Dermatologist's Perspective.

Hematol Oncol Clin North Am 2020 Jun 20;34(3):501-509. Epub 2020 Mar 20.

Department of Dermatology, The Center For Cutaneous Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, 375 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive malignancy derived from the plasmacytoid dendritic cell that commonly involves the skin. Cutaneous involvement is often the initial presentation, with deep purple or red-brown macules, plaques, or tumors. As such, dermatologists may be the first to see these patients and, in addition to oncologists, should be familiar with its presentation to facilitate early diagnosis, helping to distinguish it from acute myelogenous leukemia cutis. Read More

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http://dx.doi.org/10.1016/j.hoc.2020.01.001DOI Listing

Isolation, Characterization and Preliminary Cytotoxic and Antifungal Evaluations of Novel Lancifoliate Isolated from Methanol Extract of Conocarpus lancifolius.

Anticancer Agents Med Chem 2020 Apr 24. Epub 2020 Apr 24.

Faculty of Pharmacy, Bahaudin Zakariya University, Multan. Pakistan.

Background: Combretaceae is a large family comprising of 500 species and 20 genera distributed in subtropical and tropical regions of world. Conocarpus genus is an ornamental tree native to coastal and riverine areas of East Africa and is planted as an ornamental plant in different areas of Pakistan. This genus has proved medicinal value as a cytotoxic, antibacterial, antiprotozoal, anti-leishmanial, antifungal and antidiabetic agent. Read More

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http://dx.doi.org/10.2174/1871520620666200424110923DOI Listing
April 2020
2.469 Impact Factor

Wiedemann-steiner syndrome with a de novo mutation in KMT2A: A case report.

Medicine (Baltimore) 2020 Apr;99(16):e19813

Yinfeng Medical Laboratory, Jinan Shandong.

Rationale: Wiedemann-Steiner syndrome (WDSTS, online mendelian inheritance in man 605130) is a rare autosomal dominant disorder characterized by hypertrichosis cubiti. Here, we report a Chinese boy who do not show the characteristic of hypertrichosis cubiti, and was misdiagnosed as blepharophimosis-ptosis-epicanthus inversus syndrome at first. We found a de novo frameshift mutation (p. Read More

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http://dx.doi.org/10.1097/MD.0000000000019813DOI Listing

Case 281.

Radiology 2020 May;295(2):488-489

From the School of Medicine (A.P.K.) and Department of Respiratory and Critical Care Medicine, Shariati Hospital (R.A.), Tehran University of Medical Sciences, Karegar Street North, Tehran, Iran 1416753955.

History An 18-year-old man was diagnosed with precursor B-cell lymphoblastic leukemia and underwent transplantation of hematopoietic stem cells from his human leukocyte antigen-matched sister 1 year prior to admission. He was admitted to evaluate progressive shortness of breath and dry cough of 1-month duration. He did not report fever, night sweats, or hemoptysis. Read More

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http://dx.doi.org/10.1148/radiol.2020182474DOI Listing

RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia.

Exp Mol Pathol 2020 Apr 12;115:104440. Epub 2020 Apr 12.

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104440DOI Listing
April 2020
2.706 Impact Factor

Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas.

Nat Commun 2020 Apr 14;11(1):1806. Epub 2020 Apr 14.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Read More

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http://dx.doi.org/10.1038/s41467-020-15572-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156460PMC

Risk Factors for Keratinocyte Carcinoma in Recipients of Allogeneic Hematopoietic Cell Transplants.

JAMA Dermatol 2020 Apr 8. Epub 2020 Apr 8.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Importance: Allogeneic hematopoietic cell transplant (alloHCT) is known to increase the risk for keratinocyte carcinoma. The extent to which host characteristics, including pigmentary phenotype and UV radiation exposure, contribute is unknown.

Objective: To identify and validate independent risk factors for keratinocyte carcinoma after alloHCT, including those associated with the transplant and the host. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.0559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142796PMC

PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

Comput Struct Biotechnol J 2020 19;18:668-675. Epub 2020 Mar 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational methods for predicting MSI are based on DNA sequencing data and a few are based on mRNA expression data. Read More

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http://dx.doi.org/10.1016/j.csbj.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113609PMC

A patient with maculopapular rash and lichenoid skin damage caused by ponatinib.

J Int Med Res 2020 Apr;48(4):300060520903660

Institute of Clinical Science, Medical Faculty, University of Bergen, N-5021 Bergen, Norway.

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http://dx.doi.org/10.1177/0300060520903660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132818PMC

BRAF inhibitor and hairy cell leukemia-related transient acantholytic dermatosis.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of New Mexico, School of Medicine, Albuquerque, NM.

Grover disease (GD) is an acquired, nonfamilial, nonimmune mediated, transient or persistent acantholytic dermatosis. Herein, we present a 72-year-old man who had clinical and histopathologic findings of GD following two weeks of treatment with vemurafenib without MEK inhibitor. The patient was successfully treated with topical emollients and a high-potency corticosteroid. Read More

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February 2020

Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes.

Molecules 2020 Mar 28;25(7). Epub 2020 Mar 28.

Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

The critical roles of keratinocytes and resident mast cells in skin allergy and inflammation have been highlighted in many studies. Cyclic adenosine monophosphate (cAMP), the intracellular second messenger, has also recently emerged as a target molecule in the immune reaction underlying inflammatory skin conditions. Here, we investigated whether undecane, a naturally occurring plant compound, has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes and we further explored the potential involvement of the cAMP as a molecular target for undecane. Read More

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http://dx.doi.org/10.3390/molecules25071554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181119PMC

A fatal case of severe systemic varicella zoster infection in a patient with chronic use of immunosuppressive agents for cutaneous vasculitis.

IDCases 2020 9;19:e00667. Epub 2019 Nov 9.

Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan.

Acute varicella zoster virus (VZV) infection is a common condition in children, which is considered a mild, self-limited disease with diffuse skin vesicular rash. However, disseminated VZV infection with multiple organ involvement can occur in immunocompromised patients with impaired T cell immunity including solid or hematopoietic stem cell transplant recipients, receiving immunosuppressive therapy, leukemia, lymphoma, and HIV infection. Prompt antiviral therapy is mandatory in those immunocompromised persons. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093748PMC
November 2019

Levothyroxine treatment is associated with an increased relative risk of overall and organ specific incident cancers - a cohort study of the Swedish population.

Cancer Epidemiol 2020 Mar 26;66:101707. Epub 2020 Mar 26.

Center for Primary Health Care Research, Lund University, Malmö, Sweden; Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA; Center for Community-Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Japan.

High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ≥ 18 years in Sweden (N = 8,573,313) on January 1 2009, and identified patients with two or more dispensed prescriptions of levothyroxine 2005-2006 (n = 253,193, 3. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101707DOI Listing

CD30 lymphomatoid skin toxicity secondary to ipilimumab.

JAAD Case Rep 2020 Apr 19;6(4):251-253. Epub 2020 Mar 19.

Department of Pathology and Dermatology, MD Anderson of Houston, Houston, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2016.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082605PMC

Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells.

Biomol Ther (Seoul) 2020 Mar 25. Epub 2020 Mar 25.

Econazole, a potent broad-spectrum antifungal agent and a Ca channel antagonist, induces cytotoxicity in leukemia cells andis used for the treatment of skin infections. However, little is known about its cytotoxic effects on solid tumor cells. Here, weinvestigated the molecular mechanism underlying econazole-induced toxicity and evaluated its regulatory effect on themetastasis of gastric cancer cells. Read More

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http://dx.doi.org/10.4062/biomolther.2019.201DOI Listing

Risk factors for recurrent and metastatic cutaneous squamous cell carcinoma in immunocompromised patients.

J Am Acad Dermatol 2020 Mar 18. Epub 2020 Mar 18.

Department of Dermatology, NYU Langone Health, New York, NY.

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http://dx.doi.org/10.1016/j.jaad.2020.03.027DOI Listing
March 2020
4.449 Impact Factor

Extramedullary Disease in Multiple Myeloma.

Curr Hematol Malig Rep 2020 Apr;15(2):62-71

Plasma Cell Disorders, Department of Hematologic Oncology & Blood Disorders, Levine Cancer Institute/Atrium Health UNC School of Medicine, Charlotte, NC, USA.

Purpose Of Review: Extramedullary disease (EMD) is a rare but recognized manifestation of multiple myeloma (MM), characterized by involvement of several organs including skin, liver, lymphatic system, pleura, and central nervous system. The incidence is about 3-5% in newly diagnosed MM patients, but has been reported in up to 20% patients in the relapsed MM setting.

Recent Findings: Presence of EMD has been associated with more aggressive phenotype of MM, elevated serum lactate dehydrogenase (LDH) enzyme, and high-risk cytogenetics [deletion 17p, translocation (4;14), translocation (14;16)]. Read More

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http://dx.doi.org/10.1007/s11899-020-00568-3DOI Listing

Aleukemia cutis: Clinicopathological and molecular investigation of two cases.

J Cutan Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We describe two cases of acute myeloid leukemia (AML) who presented with cutaneous manifestations. Leukemia cutis (LC) is the cutaneous presentation of any type of leukemia and occurs in 10% to 15% of patients with AML, but cutaneous infiltration of AML rarely precedes the involvement of the bone marrow or peripheral blood and is called as "aleukemia cutis." Our first case presented with facial skin thickening, a manifestation which is known as lionization and his initial clinical diagnosis was nonspecific allergic reaction. Read More

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http://dx.doi.org/10.1111/cup.13690DOI Listing
March 2020
1.560 Impact Factor

Successful use of venetoclax for treatment of eosinophilic dermatosis of myeloproliferative disease in a patient with chronic lymphocytic leukemia.

Ann Hematol 2020 May 19;99(5):1129-1131. Epub 2020 Mar 19.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.

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http://dx.doi.org/10.1007/s00277-020-03991-xDOI Listing