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Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Section of Virology, Department of Medicine, Imperial College London

Int J STD AIDS 2019 Apr 4;30(5):522-525. Epub 2019 Feb 4.

Department of Dermatology & Venereology, Govt. Medical College, Thrissur, Kerala.

Bowenoid papulosis (BP) is a premalignant condition usually caused by oncogenic types of human papillomavirus (HPV) presenting clinically as warty genital papules. Adult T-cell leukaemia-lymphoma (ATLL) is a peripheral T-cell leukaemia-lymphoma caused by the retrovirus, human T-cell lymphotropic virus 1 (HTLV-1). We report a case of BP initially mistaken as genital warts; on detailed evaluation the patient had features of chronic immunosuppression. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):348-353

Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China,E-mail:

Objective: To detect and analyze the mutation status of FANCJ gene in adult AML patients, so as to provide the basis for studying the mechanism of FANCJ driven AML and guiding the preventim and treatment of deseese.

Methods: The cDNAs were extracted and transeripted from bone marrow cells and normal skin cells in 222 newly diagnosed AML patients. The primers were designed for FANCJ gene coding region, the mutations of FANCJ gene coding region in AML patients as well as the mutations of FANCJ gene in mucous membrane epethelia in patients were detected by PCR and sanger seguencing; the evolutionary conservation of FANCJ mutation in different organisms was analyzed by NCBI Blast online bioinformaties software. Read More

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

l-Asparaginases hydrolyzing plasma l-asparagine and l-glutamine has attracted tremendous attention in recent years owing to remarkable anticancer properties. This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in children, neoplasia, and some other malignancies. Cancer cells reduce the expression of l-asparaginase leading to their elimination. Read More

Indian J Hematol Blood Transfus 2019 Apr 6;35(2):367-368. Epub 2018 Dec 6.

3Department of Laboratory Oncology, AIIMS, New Delhi, India.

Brain Nerve 2019 Apr;71(4):334-338

Division of Dermatology, Tohoku Medical and Pharmaceutical University.

Sweet disease, also known as acute febrile neutrophilic dermatosis, is a multisystem inflammatory disorder characterized by painful erythematous plaques and aseptic neutrophilic infiltration of various organs. It is also characterized by fever, polymorphonuclear leukocytosis, and painful erythematous cutaneous plaques. Cutaneous manifestations of Sweet disease are typically painful plaque-forming erythematous papules. Read More

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. Read More

Clin Lymphoma Myeloma Leuk 2019 Mar 23. Epub 2019 Mar 23.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University, Saga, Japan; Department of Drug Discovery and Biomedical Sciences, Faculty of Medicine Saga University, Saga, Japan.

Mogamulizumab, a defucosylated humanized monoclonal antibody against the C-C chemokine receptor 4 (CCR4), has been approved for the treatment of relapsed adult T-cell leukemia/lymphoma (ATL). Compared with conventional chemotherapy, mogamulizumab monotherapy displayed more efficacy in relapsed ATL, making mogamulizumab a promising therapeutic agent. However, mogamulizumab could increase graft-versus-host disease, resulting in poor survival outcome in the allogenic stem cell transplant (allo-SCT) setting. Read More

JAMA Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.

Importance: Leukemia cutis (LC) is an important yet understudied extramedullary manifestation of leukemia. Previous reports have suggested poor prognosis for patients with LC, but these reports have largely consisted of descriptive studies with a limited number of patients.

Objectives: To identify patient factors associated with LC and characterize the association of LC with the course of acute myeloid leukemia (AML). Read More

J Oncol Pract 2019 Apr 9:JOP1800614. Epub 2019 Apr 9.

1 University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: There is little description of emergency department (ED) visits and subsequent hospitalizations among a safety-net cancer population. We characterized patterns of ED visits and explored nonclinical predictors of subsequent hospitalization, including time of ED arrival.

Patients And Methods: This was a retrospective cohort study of patients with cancer (excluding leukemia and nonmelanoma skin cancer) between 2012 and 2016 at a large county urban safety-net health system. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

Acinetobacter baumannii infection of skin and soft tissues is uncommon and usually associated with trauma. The present report describes 2 pediatric cases of cellulitis in the orofacial region, caused by A. baumannii infection with a fatal outcome. Read More

Pediatr Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Section of Dermatology, Division of Paediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Myeloid sarcoma (MS) is a rare extramedullary tumor of malignant myeloid cells often associated with acute myeloid leukemia. We report a case of a 17-year-old boy presenting with diffuse red-brown skin nodules ultimately diagnosed with the scarcely described disseminated, de novo MS. It is important for dermatologists to keep MS on their differential when assessing patients with disseminated red-brown nodules. Read More

Case Rep Pathol 2019 3;2019:4915086. Epub 2019 Mar 3.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries with an incidence of 3-5 cases per 100,000 persons. Most patients follow an indolent clinical course with eventual progression and need for therapy. In contrast, T-prolymphocytic leukemia (T-PLL) is a rare type of T-cell leukemia with most patients having an aggressive clinical course and a dismal prognosis. Read More

J Allergy Clin Immunol Pract 2019 Mar 27. Epub 2019 Mar 27.

Background: Use of penicillin skin testing (PST) to rule out penicillin (PCN) allergies is safe and effective in immunocompetent patients, however, data in immunocompromised patients are limited.

Objective: We aimed to determine safety, efficacy and clinical impact of PST in immunocompromised cancer patients.

Methods: A quality improvement process establishing a PST service was implemented at MD Anderson Cancer Center. Read More

Case Rep Hematol 2019 20;2019:3540487. Epub 2019 Feb 20.

Mayo Clinic, Jacksonville, FL, USA.

Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. Read More

Pediatr Blood Cancer 2019 Mar 22:e27732. Epub 2019 Mar 22.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Invasive fusariosis (IF) most commonly occurs in patients with hematologic malignancies and severe neutropenia, particularly during concomitant corticosteroid use. Breakthrough infections can occur in high-risk patients despite Aspergillus-active antifungal prophylaxis. We describe a patient with rapid acute lymphoblastic leukemia (ALL) progression who presented with multifocal skin nodules thought to be choloromatous disease. Read More

Arch Med Sci 2019 Mar 5;15(2):330-336. Epub 2017 Oct 5.

Department of Health Care, Center of Postgraduate Medical Education, Warsaw, Poland.

Introduction: Many epidemiological studies show a correlation between the risk of cancer and type 2 diabetes mellitus in various populations.

Material And Methods: The material was obtained from the database of the National Health Fund. This publication presents a comparison of the incidence of new malignancies in rural and urban populations of diabetic patients in Poland based on the database of the National Health Fund for the period between 1. Read More

Cutis 2018 Feb;102(2):E23-E26

Advanced Dermatology and Cosmetic Surgery of Orlando/Kansas City University, Florida, USA.

Radiol Oncol 2019 Mar 14. Epub 2019 Mar 14.

Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

Background Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a solid tumor of extramedullary localization composed of malignant primitive myeloid cells. The purpose of the study was to identify clinical and imaging features in a large patient sample. Patients and methods Overall, 71 cases (34 females (47. Read More

Int J Dermatol 2019 Mar 19. Epub 2019 Mar 19.

Research Laboratory on Skin diseases of Sanitary Interest, Center of Biological and Health Sciences, State University of Pará, Belém, Pará, Brazil.

Introduction: Individuals infected with the human T-cell lymphotropic virus type 1 (HTLV-1) commonly present skin lesions, which may be a warning sign for the diagnosis of infection. This study describes the most prevalent skin manifestations in HTLV carriers attended at the clinic of Núcleo de Medicina Tropical (NMT) of the Universidade Federal do Pará (UFPA) in Belém, Pará, Brazil.

Methods: This is a study of a series of cases of patients infected with human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) treated at NMT UFPA between 1999 and 2016. Read More

Hemasphere 2018 Oct 2;2(5):e141. Epub 2018 Oct 2.

Department of Pediatric Hematology and Oncology, Armand Trousseau Hospital, Paris, France.

Dermatol Surg 2019 Mar 12. Epub 2019 Mar 12.

Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Institute of Hematology, Zhejiang University, Hangzhou, China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China.

J Infect Chemother 2019 Mar 14. Epub 2019 Mar 14.

Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

Varicella zoster virus (VZV) infection sometimes result in visceral disseminated VZV infection (VD-VZV), which is a fulminant disease featured by abdominal pain and the absence of skin lesions, particularly occurs in the immunosuppressive patients. Brachial plexus neuritis (BPN) is another rare type of VZV infection usually appears without blisters. Few diagnostic images of both VD-VZV and BPN-VZV have been reported. Read More

Crit Rev Oncol Hematol 2019 Apr 10;136:56-63. Epub 2019 Feb 10.

Cukurova University Faculty of Medicine Dept of Medical Oncology, Adana, Turkey. Electronic address:

Bruton tyrosine kinase signaling (BTK) is critical step for B-cell development and immunoglobulin synthesis. Ibrutinib is an orally bioavailable bruton tyrosine kinase inhibitor (BTKi) and forms an irreversible covalent bound to BTK at the Cysteine-481 residue. Ibrutinib has been approved by FDA for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, marginal zone lymphoma and chronic graft-versus-host disease in allogeneic stem cell transplantation. Read More

Surv Ophthalmol 2019 Mar 11. Epub 2019 Mar 11.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA; Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA. Electronic address:

Merkel cell carcinoma (MCC) is a rare, aggressive tumor of both epithelial and neuroendocrine origin that carries a mortality rate of up to 40%. MCC tumors typically present as painless, expanding nodules on the sun-exposed skin areas of older, white patients. Eyelid and periocular tumors comprise approximately 2. Read More

Dermatol Online J 2019 Feb 15;25(2). Epub 2019 Feb 15.

Pará State University, College of Medicine, Pará.

A blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a cutaneous lymphoma derived from a plasmacytoid dendritic precursor cell that exhibits aggressive clinical behavior. Herein, we report a 46-year-old woman with a complaint of a painless nodule on the back, associated with pruritus. The nodule grew and new growths appeared over six months of evolution. Read More

Int J Dermatol 2019 Mar 7. Epub 2019 Mar 7.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.

Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Read More

Invest New Drugs 2019 Mar 7. Epub 2019 Mar 7.

Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 211100, Jiangsu Province, China.

The dyskeratosis congenita 1 (DKC1) gene is located on the X chromosome at Xq28. Dyskerin encoded by the DKC1 gene is associated with the formation of certain small RNAs and the telomerase activity. Inherited mutations in DKC1 inactivate the dyskerin and causes dyskeratosis congenital, which is characterized by skin defects, hematopoiesis failure, and increased susceptibility to cancer. Read More

Cancer Med 2019 Mar 7. Epub 2019 Mar 7.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China.

Transmembrane serine proteases have been implicated in the development and progression of solid and hematological cancers. Human airway trypsin-like protease 4 (HAT-L4) is a transmembrane serine protease expressed in epithelial cells and exocrine glands. In the skin, HAT-L4 is important for normal epidermal barrier function. Read More

Hell J Nucl Med 2019 Jan-Apr;22(1):4-5. Epub 2019 Mar 7.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, USA.

Fluorine-18 fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging was conceived in the early 1970 by investigators at the University of Pennsylvania as a research technique to measure brain metabolism and function by employing a non-invasive imaging approach. Soon after the introduction of whole-body PET instruments, F-FDG was utilized in the assessment of a variety of solid tumors and certain hematological malignancies. Yet, the role of F-FDG in assessing benign and uncommon malignant disorders of the bone marrow has not been investigated to a great extent. Read More

Genes Dev 2019 Mar 6. Epub 2019 Mar 6.

Laboratory of Receptor Biology and Gene Expression, National Cancer Insitute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Somatic mutations in the genes encoding components of the spliceosome occur frequently in human neoplasms, including myeloid dysplasias and leukemias, and less often in solid tumors. One of the affected factors, U2AF1, is involved in splice site selection, and the most common change, S34F, alters a conserved nucleic acid-binding domain, recognition of the 3' splice site, and alternative splicing of many mRNAs. However, the role that this mutation plays in oncogenesis is still unknown. Read More

Oncol Res Treat 2019 6;42(4):224-229. Epub 2019 Mar 6.

Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.

Hematological malignancies can manifest as extramedullary soft tissue masses in relatively rare cases. The rarity of it causes a diagnostic and therapeutic challenge. One of the rarest manifestations is myeloid sarcoma (MS). Read More

Int J Hematol 2019 May 4;109(5):545-552. Epub 2019 Mar 4.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 428, Houston, TX, 77030, USA.

Patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs) have near-normal life expectancies. With this comes the possibility of developing second cancers; we aimed to evaluate the incidence of second malignancies in patients with CML using Surveillance, Epidemiology, and End Results Program data. We identified 13,276 patients with CML newly diagnosed in 2001-2014. Read More

Toxicol Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida.

Arsenic exposure is a worldwide health concern associated with an increased risk of skin, lung and bladder cancer but arsenic trioxide (ATO; AsIII) is also an effective chemotherapeutic agent. The current use of AsIII in chemotherapy is limited to acute promyelocytic leukemia (APL). However, AsIII was suggested as a potential therapy for other cancer types including chronic myeloid leukemia (CML), especially when combined with other drugs. Read More

Case Rep Pulmonol 2019 21;2019:9870494. Epub 2019 Jan 21.

Wayne State University School of Medicine, Lymphoma Research Laboratory, 540 E Canfield Room No. 8829, Detroit, MI 48202, USA.

Lymphomatoid granulomatosis (LG) is an EBV-associated angiodestructive lymphoproliferative disease with multiorgan involvement that predominantly affects the lungs. We present a case of a 72-year-old man with a history of chronic lymphocytic leukemia who presented with upper respiratory symptoms and multiple erythematous skin papules. Chest CT showed ill-defined, irregular solid pulmonary nodules with peripheral ground-glass opacities in a peribronchovascular distribution. Read More

Med Lav 2019 Feb 22;110(1):3-10. Epub 2019 Feb 22.

Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano.

Background: Oil refinery workers are exposed to several well-established carcinogens and working in this type of industry has been classified by IARC as probable carcinogen to humans (Group 2A).

Objectives: To examine the mortality experience of workers employed in four Italian oil refineries.

Methods: The cohort included 5112 male workers ever employed between 1949 and 2011. Read More

Int J Hematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Hematology, Ome Municipal General Hospital, 4-16-5, Higashiome, Ome, Tokyo, Japan.

A 64-year-old man was diagnosed with limited cutaneous systemic sclerosis 5 years prior to this report. His sclerotic skin symptoms did not respond to oral low-dose prednisone (5-10 mg/day). Five years after the diagnosis, the patient presented with leukocytosis 3. Read More

Indian Dermatol Online J 2019 Jan-Feb;10(1):61-63

Department of Skin and VD, SBH Govt. Medical College, Dhule, Department of Skin and VD, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

Eosinophilic dermatosis of hematologic malignancy is a rare paraneoplastic manifestation particularly associated with chronic lymphocytic leukemia (CLL).Clinically, it presents as a peculiar polymorphic pruritic eruption with characteristic histological findings of superficial and deep dense perivascular infiltrate of lymphocytes and eosinophils without any vasculitis. Although it has been reported intermittently with different names, there is paucity of reports of this condition in Indian literature. Read More

Cleve Clin J Med 2019 Feb;86(2):85-86

Department of Hematology and Oncology, Captain James A. Lovell Federal Healthcare Center, North Chicago, IL, USA.

Eur J Haematol 2019 May 12;102(5):407-415. Epub 2019 Mar 12.

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.

Objective: This prospective, observational, postmarketing surveillance was conducted to evaluate the safety and effectiveness of mogamulizumab, an anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, in patients with CCR4-positive, relapsed or refractory (r/r) adult T-cell leukemia-lymphoma (ATL) in Japan.

Method: All patients were scheduled to receive intravenous infusions of mogamulizumab 1.0 mg/kg once weekly for 8 weeks, alone or in combination with other modalities. Read More

Dermatol Res Pract 2019 13;2019:9891270. Epub 2019 Jan 13.

Intermediate Care Unit, King Abdulaziz Medical City (KAMC), National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia.

Skin manifestations are common in hematology ward patients and can result from infection, malignancy, or chemotherapy. The purpose of this study was to identify the most common dermatological problems encountered in the adult hematology ward at King Abdullah Specialist Children Hospital (KASCH). This was retrospective chart review of 78 dermatology consultations based on electronic health records for all inpatients in hematology wards at KASCH between January 2016 and December 2017. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14344

Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy. This disease almost always presents with cutaneous involvement.

Patient Concerns: The 1st patient was a 16-year-old girl who presented with recurrent epistaxis. Read More

Pediatr Blood Cancer 2019 Jun 7;66(6):e27647. Epub 2019 Feb 7.

Departments of Pediatrics, Pathology and Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: At least 80% of children with cancer live in low- and middle-income countries where the prevalence of malnutrition and socioeconomic disadvantage is high. We examined the relationship between nutritional status (NS), assessed by arm anthropometry, and socioeconomic status (SES) in children diagnosed with cancer at Unidad Nacional de Oncologia Pediatrica (UNOP) in Guatemala over a three-year period.

Method: Patients aged 0 to 18 years of age diagnosed between January 2015 and December 2017 were included. Read More

Rinsho Ketsueki 2019;60(1):22-27

Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University.

A 44-year-old male was diagnosed with acute myeloid leukemia with a complex karyotype. He underwent bone marrow transplantation using an HLA 6/6 antigen-matched sibling donor, but developed chronic graft-versus-host disease (cGVHD) with skin erythema and oral and esophageal lichen planus changes. Treatment with a combination of prednisolone and cyclosporine was initiated on day 646 after transplantation, but oral symptoms persisted. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):111-113

Dermatology Service, Universidade Federal do Pará, Belém (PA), Brazil.

Biol Blood Marrow Transplant 2019 Feb 1. Epub 2019 Feb 1.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington. Electronic address:

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic cell disease characterized by the destruction of hematopoietic cells through activation of the complement system with manifestations that can be life-threatening including hemolysis, thrombosis, and marrow failure. Allogeneic hematopoietic cell transplantation (HCT) remains the sole cure for PNH, but eculizumab, a terminal complement inhibitor of C5, has been used to prevent complement-mediated hemolysis in patients with PNH since its approval by the Food and Drug Administration in 2007. We examined outcomes of HCT in patients with PNH to evaluate the effects of disease subtype, conditioning intensity, and eculizumab use either pre-HCT or post-HCT. Read More

Lancet Haematol 2019 Feb;6(2):e100-e109

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Therapeutic approaches for B-cell malignancies continue to evolve, especially with regard to combination approaches. We assessed the safety and efficacy of the triplet ublituximab, umbralisib, and ibrutinib in patients with advanced B-cell malignancies.

Methods: We did an open-label, phase 1 study with dose-escalation and dose-expansion phases, at five centres in the USA. Read More

Dermatol Ther 2019 Feb 1:e12849. Epub 2019 Feb 1.

Department of Dermatology, People's Hospital of Peking University, Beijing, China.

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Tetra-arsenic tetra-sulfide (As S ), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects. In our previous study, BXSB lupus-prone mice treated with As S has showed improved monocytosis, decreased serum interleukin (IL)-6 and suppressed skin, liver and renal lesions with well-tolerance. Read More

Br J Haematol 2019 Apr 31;185(2):232-239. Epub 2019 Jan 31.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Read More