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    Mastocytosis: from a Molecular Point of View.
    Clin Rev Allergy Immunol 2017 Jul 19. Epub 2017 Jul 19.
    Floridsdorf Allergy Center (FAZ), Vienna, Austria.
    Mast cells (MCs) are physiologically activated by binding of stem cell factor (SCF) to the extracellular domains of the Kit receptor. This binding increases the proliferation and prolongs the survival of normal mature MCs, as well as intensifies the release of mediators. In mastocytosis, somatic mutations of the coding Kit gene cause autocrine dysregulation and lead to constitutive KIT activation even in the absence of its ligand SCF. Read More

    Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat.
    Pain 2017 May 30. Epub 2017 May 30.
    aPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USAbDepartments of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
    Vincristine (VNC) is commonly used to treat pediatric cancers, including the most prevalent childhood malignancy, acute lymphoblastic leukemia. Although clinical evidence suggests that VNC causes peripheral neuropathy in children, the degree to which pediatric chemotherapeutic regimens influence pain sensitivity throughout life remains unclear, in part because of the lack of an established animal model of chemotherapy-induced neuropathic pain during early life. Therefore, this study investigated the effects of VNC exposure between postnatal days (P) 11 and 21 on mechanical and thermal pain sensitivity in the developing rat. Read More

    Cancer survival in adult patients in Spain. Results from nine population-based cancer registries.
    Clin Transl Oncol 2017 Jul 17. Epub 2017 Jul 17.
    CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
    Introduction: With the aim of providing cancer control indicators, this work presents cancer survival in adult (≥15 years) patients in Spain diagnosed during the period 2000-2007 from Spanish cancer registries participating in the EUROCARE project.

    Methods: Cancer cases from nine Spanish population-based cancer registries were included and analysed as a whole. All primary malignant neoplasms diagnosed in adult patients were eligible for the analysis. Read More

    Risk of Second Primary Malignancies in Patients With Follicular Lymphoma: A United States Population-based Study.
    Clin Lymphoma Myeloma Leuk 2017 Jun 24. Epub 2017 Jun 24.
    Division of Hematology-Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
    Background: With the improving outcomes of patients with follicular lymphoma (FL), it is imperative to focus on survivorship issues, including the development of second primary malignancies (SPMs). We used a large US database to measure the risk of SPMs among FL survivors.

    Materials And Methods: We used the Surveillance, Epidemiology, and End Results-13 registry to identify FL patients from 1992 to 2011. Read More

    Role of Zucchini and Its Distinctive Components in the Modulation of Degenerative Processes: Genotoxicity, Anti-Genotoxicity, Cytotoxicity and Apoptotic Effects.
    Nutrients 2017 Jul 14;9(7). Epub 2017 Jul 14.
    Department of Genomics and Biotechnology, IFAPA (Andalusian Institute of Agricultural Research and Training, Fisheries, Food and Ecological Production) Center La Mojonera, Camino San Nicolás, 1 La Mojonera, 04745 Almería, Spain.
    Zucchini (Cucurbita pepo subsp. pepo) is a seasonal vegetable with high nutritional and medical values. Many useful properties of this fruit are attributed to bioactive compounds. Read More

    Dietary protein levels regulated antibacterial activity, inflammatory response and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella) after challenged with Aeromonas hydrophila.
    Fish Shellfish Immunol 2017 Jul 8;68:154-172. Epub 2017 Jul 8.
    Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China. Electronic address:
    This study investigated the effects of dietary protein levels on disease resistance, immune function and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella). A total of 540 grass carp (264.11 ± 0. Read More

    [Adverse effects of high-dose methotrexate therapy].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Jul;19(7):781-785
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
    Objective: To investigate the adverse effects of high-dose methotrexate (HDMTX) therapy, and to provide a theoretical basis for optimizing clinical treatment.

    Methods: A retrospective analysis was performed for the clinical data of 120 children with acute lymphoblastic leukemia or non-Hodgkin lymphoma who underwent 601 times of HDMTX therapy. The adverse effects of various systems were analyzed according to the WHO criteria for the classification of adverse effects of anticancer drugs. Read More

    Prevalence of cutaneous viral infections in incident cutaneous squamous cell carcinoma detected among chronic lymphocytic leukemia and hematopoietic stem cell transplant patients.
    Leuk Lymphoma 2017 Jul 6:1-7. Epub 2017 Jul 6.
    a Department of Cancer Epidemiology , Moffitt Cancer Center , Tampa , FL , USA.
    The role of cutaneous viral infections in the development of non-melanoma skin cancer (NMSC), including cutaneous squamous cell carcinoma (SCC), among chronic lymphocytic leukemia (CLL) and blood and marrow transplant (BMT) patients is not established. CLL (n = 977) and BMT (n = 3587) patients treated at the Moffitt Cancer Center were included in a retrospective cohort study. Human papillomavirus (HPV) and human polyomavirus (HPyV) DNA were examined in a subset of incident SCC tumors. Read More

    Mixed phenotypic acute leukemia with leukemia cutis and neuroleukemiosis.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):334-335
    Department of Medical Oncology, Regional Cancer Centre, Trivandrum, India.
    Leukemia cutis and neuroleukemiosis are two rare extramedullary manifestations of acute leukemia. We report a 32-year-old woman with multiple skin lesions and painful peripheral neuropathy. Bone marrow biopsy and skin biopsy confirmed the diagnosis of mixed phenotypic acute leukemia. Read More

    Idelalisib may have the potential to increase radiotherapy side effects.
    Radiat Oncol 2017 Jun 28;12(1):109. Epub 2017 Jun 28.
    Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, D-91054, Erlangen, Germany.
    Introduction: Idelalisib is approved for the treatment of relapsed chronic lymphocytic leukemia together with Rituximab and for monotherapy of follicular B-cell non-Hodgkin's lymphoma and small lymphocytic lymphoma. It is a potent and selective phosphatidylinositol 3-kinase-δ (PI3K-δ) inhibitor. PI3K-δ primarily is expressed in B-cells and prevents effectively proliferation in malignant B-cells. Read More

    Mogamulizumab for the treatment of T-cell lymphoma.
    Expert Opin Biol Ther 2017 Jul 3:1-9. Epub 2017 Jul 3.
    a Department of Hematology , National Cancer Center Hospital , Tokyo , Japan.
    Introduction: T-cell lymphoma is a relatively rare hematologic malignancy that accounts for 10-20% of non-Hodgkin lymphomas. Treatment strategies for T-cell lymphomas are different from that for B-cell lymphomas and have poor prognoses. Among various subtypes of T-cell lymphomas, adult T-cell leukemia-lymphoma (ATL) has the worst prognosis. Read More

    [Adult T-cell leukemia/lymphoma. Report of a case in Uruguay].
    Medicina (B Aires) 2017 ;77(3):235-238
    Laboratorio de Citometría de Flujo y Biología Molecular, Departamento Básico de Medicina, Montevideo, Uruguay. E-mail:
    Adult T-cell leukemia/lymphoma belongs to the group of mature T-cell malignancies according to the WHO classification. It constitutes a rare entity and has a strong association with infection by human T-lymphotropic virus 1. In Uruguay, this viral infection is very infrequent and, to our knowledge, no case of adult T-cell leukemia/lymphoma has been previously reported. Read More

    [Clinical and Pathologic Features of Myeloid Sarcoma].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Jun;25(3):926-931
    Department of Hematology, The Second People's Hospital of Lianyungang City, Lianyungang 222000, Jiangsu Province, China.
    Objective: To explore the clinicopathologic features, differential diagnosis and therapy of myeloid sarcoma.

    Methods: The clinical data including clinical manifestations, laboratorial tests, histopathologicical examination, immunohistochemistry and clinical prognosis of 10 patients with myeloid sarcoma were analyzed retrospectively. Among 10 patients, 5 male and 5 female, aged 23 to 71 years old (median = 36 years). Read More

    The NF1 somatic mutational landscape in sporadic human cancers.
    Hum Genomics 2017 Jun 21;11(1):13. Epub 2017 Jun 21.
    Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
    Background: Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man (OMIM) #162200) is an autosomal dominantly inherited tumour predisposition syndrome. Heritable constitutional mutations in the NF1 gene result in dysregulation of the RAS/MAPK pathway and are causative of NF1. The major known function of the NF1 gene product neurofibromin is to downregulate RAS. Read More

    Systemic interferon alfa injections for the treatment of a giant orf.
    Cutis 2017 May;99(5):E19-E21
    Department of Dermatology, Istanbul Training and Research Hospital, Turkey.
    Orf is a zoonotic infection caused by a parapoxvirus and is endemic in sheep and goats. It may be transmitted to humans by direct contact with infected animals. We report a case of a giant orf in a patient with chronic lymphocytic leukemia (CLL), which proliferated dramatically after surgical excision and resolved after systemic interferon alfa-2a injections. Read More

    Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.
    Int J Mol Med 2017 Aug 14;40(2):454-464. Epub 2017 Jun 14.
    Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
    Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis. As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP against carbon tetrachloride (CCl4)-induced liver injury. Our data indicated that hSAP attenuated hepatic histopathological abnormalities and significantly decreased inflammatory cell infiltration and pro-inflammatory factor expression. Read More

    Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case.
    Hematol Rep 2017 Jun 1;9(2):6997. Epub 2017 Jun 1.
    Hematology Clinic and Bone Marrow Transplantation Unit, Ankara, Turkey.
    Invasive pulmonary aspergillosis is most commonly seen in immunocompromised patients. Besides, skin lesions may also develop due to invasive aspergillosis in those patients. A 49-year-old male patient was diagnosed with acute myeloid leukemia. Read More

    Leukemia Cutis Associated with Secondary Plasma Cell Leukemia.
    Cureus 2017 May 9;9(5):e1235. Epub 2017 May 9.
    Department of Dermatology, University of California, San Diego.
    Plasma cell leukemia is an uncommon, aggressive variant of leukemia that may occur de novo or in association with multiple myeloma. Leukemia cutis is the cutaneous manifestation of leukemia, and indicates an infiltration of the skin by malignant leukocytes or their precursors. Plasma cell leukemia cutis is a rare clinical presentation of leukemia. Read More

    Melanization of Fusarium keratoplasticum (F. solani Species Complex) During Disseminated Fusariosis in a Patient with Acute Leukemia.
    Mycopathologia 2017 Jun 14. Epub 2017 Jun 14.
    Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
    Fusarium spp. are recognized as the second most frequently filamentous fungi causing opportunistic infections and particularly important due to the increasing number of immunocompromised patients. F. Read More

    Safety and efficacy of mogamulizumab in patients with adult T-cell leukemia-lymphoma in Japan: interim results of postmarketing all-case surveillance.
    Int J Hematol 2017 Jun 9. Epub 2017 Jun 9.
    Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.
    We present the interim results of a postmarketing all-case surveillance study in patients with C-C chemokine receptor 4 (CCR4)-positive, relapsed or refractory adult T-cell leukemia-lymphoma (ATL) treated with the anti-CCR4 monoclonal antibody mogamulizumab since its 2012 launch in Japan. The safety and efficacy analysis populations comprised 484 and 442 patients, respectively. The ATL subtype was acute in 58. Read More

    Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy.
    Indian J Hematol Blood Transfus 2017 Jun 11;33(2):273-275. Epub 2016 Aug 11.
    Department of Internal Medicine and Hematology, 4th Floor, Nehru Hospital, PGIMER, Chandigarh, India.
    Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis seen in association with systemic disorders including hematologic malignancies. Hairy cell leukemia (HCL) however, is an unusual association of PG. We describe a 49-year old lady who presented to our hematology clinic with easy fatiguability and ulcerative skin lesions of 6 months duration. Read More

    Haploidentical transplantation using post-transplant high-dose cyclophosphamide for adult T-cell lymphoma after mogamulizumab treatment.
    Rinsho Ketsueki 2017 ;58(5):449-454
    Department of Hematology, University of Tsukuba Hospital.
    A 53-year-old man diagnosed with adult T-cell lymphoma (ATL) was treated with mLSG15 chemotherapy and achieved a first complete remission. Subsequently, a liver tumor emerged that was pathologically diagnosed as ATL (first relapse). A second remission was achieved after local irradiation and four cycles of mogamulizumab treatment. Read More

    Acute myeloid leukemia developing secondary immune thrombocytopenia after umbilical cord blood transplantation.
    Rinsho Ketsueki 2017 ;58(5):433-437
    Department of Hematology and Oncology, University of Fukui.
    A 64-year-old man was diagnosed with acute myeloid leukemia M2 (FLT3-ITD-positive). After induction chemotherapy and four courses of consolidation therapy, he underwent umbilical cord blood transplantation (CBT) in his first remission. He developed acute graft-versus-host disease (skin stage 2) after successful engraftment. Read More

    A Severe Case of Cutaneous Adverse Drug Reaction Secondary to a Novice Drug: Idelalisib.
    J Investig Med High Impact Case Rep 2017 Apr-Jun;5(2):2324709617711463. Epub 2017 May 24.
    East Tennessee State University, Johnson City, TN, USA.
    Phosphatidylinositol 3-kinase δ (PIK3δ) is a tyrosine kinase essential for B cell survival, making it an important target in the treatment of chronic lymphocytic leukemia. Idelalisib is an inhibitor of PIK3δ demonstrating initial success in disease response, but is now shown to have a decreased overall survival and life-threatening serious adverse events. The following is an unfortunate case of a grade III adverse skin reaction secondary to idelalisib with the likely complication of methicillin-resistant Staphylococcus aureus bacteremia. Read More

    Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia.
    Adv Hematol 2017 14;2017:6464972. Epub 2017 May 14.
    Department of Pharmacy, West Virginia University Medicine, Morgantown, WV, USA.
    Relapsed/refractory acute myeloid leukemia (RR-AML) is associated with poor prognosis and long-term disease-free survival requires allogeneic hematopoietic cell transplantation (allo-HCT). Limited data exists, regarding the optimal regimen to obtain remission prior to allo-HCT. Single agent high-dose cytarabine (10-12 doses administered every 12 hours) has been previously used as induction therapy. Read More

    Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion.
    Blood 2017 Jun 6. Epub 2017 Jun 6.
    Immunology Research Area, IRCCS Ospedale Bambino Gesu, Rome, Italy.
    Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-haploidentical relative (haplo-HSCT) is a suitable option for children with acute leukemia (AL) either relapsed or at high-risk of treatment failure. We developed a novel method of graft manipulation based on negative depletion of αβ T and B cells and conducted a prospective trial evaluating the outcome of children with AL transplanted with this approach (ClinicalTrial.gov identifier: NCT01810120). Read More

    Clinical characteristics, molecular profile and outcomes of myeloid sarcoma: a single institution experience over 13 years.
    Hematology 2017 Jun 2:1-8. Epub 2017 Jun 2.
    b Division of Hematology and Oncology , Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    Background: Myeloid sarcoma (MS) is characterized by extramedullary infiltration by immature myeloid cells. Owing to rarity of this disease, the clinical features and overall outcomes are yet to be clarified.

    Objective: To define clinical characteristics, epidemiology, pathologic findings, treatment options and outcomes in MS. Read More

    Influence of cytarabine metabolic pathway polymorphisms in acute myeloid leukemia induction treatment.
    Leuk Lymphoma 2017 Jun 2:1-15. Epub 2017 Jun 2.
    a Unidad de Farmacogenética, Instituto Investigación Sanitaria La Fe and Área del Medicamento , Hospital Universitario y Politécnico La Fe. , Valencia , Spain.
    Cytarabine is considered the most effective chemotherapeutic option in acute myeloid leukemia (AML). The impact of 10 polymorphisms in cytarabine metabolic pathway genes were evaluated in 225 adult de novo AML patients. Variant alleles of DCK rs2306744 and CDA rs602950 showed higher complete remission (p = . Read More

    Neurologic Complications of Lymphoma, Leukemia, and Paraproteinemias.
    Continuum (Minneap Minn) 2017 Jun;23(3, Neurology of Systemic Disease):669-690
    Purpose Of Review: This article reviews the spectrum of neurologic complications associated with lymphoma, leukemia, and paraproteinemic disorders. While leptomeningeal metastasis is the most common complication of lymphoma and leukemia and peripheral neuropathy is the most common complication of paraproteinemic disorders, clinicians need to be familiar with the diverse neurologic complications of these disorders.

    Recent Findings: Lymphomatous nervous system involvement can be difficult to diagnose, especially when it is the presenting symptom. Read More

    Impact of novel polymorphisms related to cytotoxicity of cytarabine in the induction treatment of acute myeloid leukemia.
    Pharmacogenet Genomics 2017 Jul;27(7):270-274
    aPharmacogenetics Unit, Institute for Health Research La Fe and Drug Clinical Area bDepartment of Pharmacy, Drug Clinical Area cDepartment of Hematology dClinical Pharmacology Unit, Hospital Universitari i Politecnic La Fe eDepartment of Pharmacology, Faculty of Medicine, Universidad de Valencia, Valencia, Spain.
    Several novel single nucleotide polymorphisms (SNPs) involved in cytarabine cytotoxicity and related to clinical outcomes have been reported recently in a series of 232 pediatric patients with acute myeloid leukemia (AML). We report the first adult AML cohort in which the influence of these SNPs in cytarabine efficacy and toxicity was analyzed. Six of polymorphisms with clinical significance in the previous study [rs12036333, rs10758713, rs9883101, rs6550826, IRX2: rs2897047, mutated in colorectal cancers (MCC): rs7729269] were analyzed in a cohort of 225 adult patients at initial diagnosis of AML treated with an induction scheme of idarubicin plus cytarabine. Read More

    [Analysis of clinical efficacy of recombinant activated factor Ⅶ on bleeding in patients with hematologic disorders].
    Zhonghua Xue Ye Xue Za Zhi 2017 May;38(5):410-414
    Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
    Objective: To investigate the treatment efficacy of recombinant activated factor Ⅶ (rFⅦa) for bleeding among patients with hematologic disorders. Methods: A total of 38 times of bleeding in 31 patients with hematological disease treated with rFⅦa were analyzed retrospectively. Results: The clinical effective rate of rFⅦa for bleeding management in acquired hemophilia A (AHA) patients/hemophilia patients with inhibitor, acute promyelocytic leukemia (APL) patients and patients with non-APL leukemia was 90% (9/10) , 71. Read More

    Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
    Colomb Med (Cali) 2017 Mar 30;48(1):35-38. Epub 2017 Mar 30.
    Escuela de Medicina Facultad de Salud, Universidad del Valle Cali, Colombia.
    Background: Adult T-cell Leukemia/Lymphoma (ATLL) is classified as a peripheral CD4+ T-cell neoplasm caused by the human T-cell lymphotropic virus type 1 (HTLV-1). Typical symptoms are associated with leukemic infiltration; however, atypical and exaggerated manifestations of verrucous carcinoma have also been described.

    Case Report: We present here the case of a patient with multiple skin lesions, ischemic necrosis in the hallux and lymphadenopathies. Read More

    Extramedullary disease at diagnosis of AML does not influence outcome of patients undergoing allogeneic hematopoietic cell transplant in CR1.
    Eur J Haematol 2017 May 27. Epub 2017 May 27.
    Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
    Objective: Extramedullary disease (EMD) at diagnosis of acute myeloid leukemia (AML) has been associated with increased risk of relapse and worse outcomes post-chemotherapy. This study sought to investigate the association of EMD with outcomes following allogeneic hematopoietic cell transplantation (allo-HCT).

    Methods: This single-center retrospective study investigated the impact of EMD at diagnosis on the outcome of patients transplanted for AML in first complete remission (CR1). Read More

    The clinical spectrum of Erdheim-Chester disease: an observational cohort study.
    Blood Adv 2017 Feb;1(6):357-366
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health. 10 Center Dr, Bldg 10, Room 3-2551, Bethesda, Maryland, USA, 20892. Telephone: 301-594-2952.
    Erdheim-Chester Disease (ECD) is a rare, potentially fatal, multi-organ myeloid neoplasm occurring mainly in adults. The diagnosis is established by clinical, radiologic, and histologic findings; ECD tumors contain foamy macrophages that are CD68+, CD163+, CD1a-, and frequently S100-. The purpose of this report is to describe the clinical and molecular variability of ECD. Read More

    C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation.
    PLoS Genet 2017 May 26;13(5):e1006801. Epub 2017 May 26.
    Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, Freiburg, Baden-Wuerttemberg, Germany.
    Activation of the FOXO transcription factor DAF-16 by reduced insulin/IGF signaling (IIS) is considered to be beneficial in C. elegans due to its ability to extend lifespan and to enhance stress resistance. In the germline, cell-autonomous DAF-16 activity prevents stem cell proliferation, thus acting tumor-suppressive. Read More

    Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T-cell malignancies.
    Am J Hematol 2017 May 20. Epub 2017 May 20.
    Veterans Affairs Medical Center, Washington D.C., 20422, USA.
    With the emerging success of treating CD19 expressing B cell malignancies with ex vivo modified, autologous T cells that express CD19-directed chimeric antigen receptors (CAR), there is intense interest in expanding this evolving technology to develop effective modalities to treat other malignancies including solid tumors. Exploiting this approach to develop a therapeutic modality for T cell malignancies for which the available regimens are neither curative, nor confer long term survival we generated a lentivirus-based CAR gene transfer system to target the chemokine receptor CCR4 that is over-expressed in a spectrum of T cell malignancies as well as in CD4(+) CD25(+) Foxp3(+) T regulatory cells that accumulate in the tumor microenvironment constituting a barrier against anti-tumor immunity. Ex vivo modified, donor-derived T cells that expressed CCR4 directed CAR displayed antigen-dependent potent cytotoxicity against patient-derived cell lines representing ATL, CTCL, ALCL and a subset of HDL. Read More

    Mesenchymal stem cells (MSCs) attenuate cutaneous sclerodermatous graft-versus-host disease (Scl-GVHD) through inhibition of immune cell infiltration in a mouse model.
    J Invest Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea. Electronic address:
    Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD) model that is characterized by skin thickening and lung fibrosis. A B10.D2 → BALB/c transplant model of Scl-GVHD was used to address the therapeutic effect of mesenchymal stem cells (MSCs) on the development of CGVHD. Read More

    Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man.
    Case Rep Dermatol 2017 Jan-Apr;9(1):103-107. Epub 2017 Apr 7.
    aDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. Read More

    Isolated Central Nervous System (CNS) Relapse in Paediatric Acute Promyelocytic Leukaemia: A Systematic Review.
    J Clin Diagn Res 2017 Mar 1;11(3):XE05-XE08. Epub 2017 Mar 1.
    Senior Resident, Department of Pathology and Laboratory Medicine, Medanta-the Medicity, Gurugram, Haryana, India.
    Introduction: Extramedullary disease, as a whole, is rare in Acute Promyelocytic Leukaemia (APML). If at all relapse occurs, following sites are involved: Central Nervous System (CNS), skin, testes, mediastinum, gingiva, and ear. Isolated CNS relapses after complete morphological and molecular remission is rarer particularly in children. Read More

    Impact of pharmacokinetics on the toxicity and efficacy of clofarabine in patients with relapsed or refractory acute myeloid leukemia.
    Leuk Lymphoma 2017 May 16:1-10. Epub 2017 May 16.
    b Universitätsklinikum Carl Gustav Carus der TU Dresden , Medizinische Klinik und Poliklinik I , Dresden , Germany.
    Common side effects of clofarabine (CFB) are liver toxicity, particularly a transient elevation of transaminases and skin toxicity. We studied the correlation of pharmacokinetic (PK) parameters with these toxicities and the efficacy of CFB in patients with relapsed or refractory acute myeloid leukemia. Clofarabine PK parameters showed large inter-individual variability. Read More

    Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
    J Rheumatol 2017 May 15. Epub 2017 May 15.
    From the Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. Supported by a grant for Research on Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan. T. Taniguchi, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; Y. Asano, MD, PhD, Associate Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; K. Nakamura, MD, Graduate Student, Department of Dermatology, University of Tokyo Graduate School of Medicine; T. Yamashita, MD, Graduate Student, Department of Dermatology, University of Tokyo Graduate School of Medicine; R. Saigusa, MD, Graduate Student, Department of Dermatology, University of Tokyo Graduate School of Medicine; Y. Ichimura, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; T. Takahashi, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; T. Toyama, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; A. Yoshizaki, MD, PhD, Lecturer, Department of Dermatology, University of Tokyo Graduate School of Medicine; S. Sato, MD, PhD, Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine. Address correspondence to Dr. Y. Asano, Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. E-mail: Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication April 17, 2017.
    Objective: CXCL6, a chemokine with proangiogenic property, is reported to be involved in vasculopathy associated with systemic sclerosis (SSc). We investigated the contribution of CXCL6 to SSc development by focusing on the association of friend leukemia virus integration 1 (Fli1) deficiency, a potential predisposing factor of SSc, with CXCL6 expression and clinical correlation of serum CXCL6 levels.

    Methods: mRNA levels of target genes and the binding of Fli1 to the CXCL6 promoter were evaluated by quantitative reverse transcription-PCR and chromatin immunoprecipitation, respectively. Read More

    Infectious complications in chronic lymphocytic leukemia- a retrospective analysis: single institution experience.
    Neoplasma 2017 ;64(3):474-481
    The aim of this study was to evaluate the incidence of a variety of infectious complications in patients with CLL regarding the duration of CLL and the type of treatment. We present the retrospective analysis of patients with CLL treated at our institution in years 2004-2016. We collected data about the type of infection, pathogenes, treatment and severity of infections surpassed in connection with administration treatment. Read More

    Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation.
    Pediatr Transplant 2017 Aug 12;21(5). Epub 2017 May 12.
    Department of Pediatrics, Oita University Faculty of Medicine, Oita University, Oita, Japan.
    TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Read More

    RUNX transcription factors at the interface of stem cells and cancer.
    Biochem J 2017 May 10;474(11):1755-1768. Epub 2017 May 10.
    UCL Cancer Institute, University College London, London WC1E 6BT, U.K.
    The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes in RUNX1 are linked to loss of function classifying it broadly as a tumour suppressor. Despite this, several recent studies have reported the need for a certain level of active RUNX1 for the maintenance and propagation of acute myeloid leukaemia and acute lymphoblastic leukaemia cells, suggesting an oncosupportive role of RUNX1. Read More

    In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies.
    Sci Rep 2017 May 8;7(1):1526. Epub 2017 May 8.
    Departamento de Medicina Oncológica, Oncosalud-AUNA, Av. Guardia Civil 571, San Borja. Lima 41, Peru.
    DDIT4 gene encodes a protein whose main action is to inhibit mTOR under stress conditions whilst several in vitro studies indicate that its expression favors cancer progression. We have previously described that DDIT4 expression is an independent prognostic factor for tripe negative breast cancer resistant to neoadjuvant chemotherapy. We herein report that high DDIT4 expression is related to the outcome (recurrence-free survival, time to progression and overall survival) in several cancer types. Read More

    Adult T-cell leukemia-lymphoma complicated by Takotsubo cardiomyopathy and HTLV-1-associated myelopathy after treatment with the anti-CCR4 antibody mogamulizumab.
    Rinsho Ketsueki 2017 ;58(4):309-314
    Department of Hematology, Nippon Medical School.
    Adult T-cell leukemia-lymphoma (ATL) caused by human T-lymphotropic virus type 1 (HTLV-1) is generally associated with poor prognosis. The anti-CCR4 antibody mogamulizumab is one of the options for refractory or relapsed ATL. Mogamulizumab is intravenously administered as a single agent at a dose of 1. Read More

    Single-institutional retrospective analysis of Japanese patients with chronic lymphocytic leukemia.
    Rinsho Ketsueki 2017 ;58(4):282-286
    Division of Hematology, Department of Medicine, Keio University School of Medicine.
    Unlike in Western countries, chronic lymphocytic leukemia (CLL) is a rare lymphoid malignancy in Japan, and its clinical features remain to be elucidated in the Japanese population. Therefore, we retrospectively analyzed 29 Japanese CLL patients newly diagnosed at our institute. Seventeen (59%) were male, and their median age was 62 years. Read More

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