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    Mesenchymal stem cells (MSCs) attenuate cutaneous sclerodermatous graft-versus-host disease (Scl-GVHD) through inhibition of immune cell infiltration in a mouse model.
    J Invest Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea. Electronic address:
    Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD) model that is characterized by skin thickening and lung fibrosis. A B10.D2 → BALB/c transplant model of Scl-GVHD was used to address the therapeutic effect of mesenchymal stem cells (MSCs) on the development of CGVHD. Read More

    Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man.
    Case Rep Dermatol 2017 Jan-Apr;9(1):103-107. Epub 2017 Apr 7.
    aDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. Read More

    Isolated Central Nervous System (CNS) Relapse in Paediatric Acute Promyelocytic Leukaemia: A Systematic Review.
    J Clin Diagn Res 2017 Mar 1;11(3):XE05-XE08. Epub 2017 Mar 1.
    Senior Resident, Department of Pathology and Laboratory Medicine, Medanta-the Medicity, Gurugram, Haryana, India.
    Introduction: Extramedullary disease, as a whole, is rare in Acute Promyelocytic Leukaemia (APML). If at all relapse occurs, following sites are involved: Central Nervous System (CNS), skin, testes, mediastinum, gingiva, and ear. Isolated CNS relapses after complete morphological and molecular remission is rarer particularly in children. Read More

    Impact of pharmacokinetics on the toxicity and efficacy of clofarabine in patients with relapsed or refractory acute myeloid leukemia.
    Leuk Lymphoma 2017 May 16:1-10. Epub 2017 May 16.
    b Universitätsklinikum Carl Gustav Carus der TU Dresden , Medizinische Klinik und Poliklinik I , Dresden , Germany.
    Common side effects of clofarabine (CFB) are liver toxicity, particularly a transient elevation of transaminases and skin toxicity. We studied the correlation of pharmacokinetic (PK) parameters with these toxicities and the efficacy of CFB in patients with relapsed or refractory acute myeloid leukemia. Clofarabine PK parameters showed large inter-individual variability. Read More

    Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
    J Rheumatol 2017 May 15. Epub 2017 May 15.
    From the Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. Supported by a grant for Research on Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan. T. Taniguchi, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; Y. Asano, MD, PhD, Associate Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; K. Nakamura, MD, Graduate Student, Department of Dermatology, University of Tokyo Graduate School of Medicine; T. Yamashita, MD, Graduate Student, Department of Dermatology, University of Tokyo Graduate School of Medicine; R. Saigusa, MD, Graduate Student, Department of Dermatology, University of Tokyo Graduate School of Medicine; Y. Ichimura, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; T. Takahashi, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; T. Toyama, MD, PhD, Assistant Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine; A. Yoshizaki, MD, PhD, Lecturer, Department of Dermatology, University of Tokyo Graduate School of Medicine; S. Sato, MD, PhD, Professor, Department of Dermatology, University of Tokyo Graduate School of Medicine. Address correspondence to Dr. Y. Asano, Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. E-mail: Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication April 17, 2017.
    Objective: CXCL6, a chemokine with proangiogenic property, is reported to be involved in vasculopathy associated with systemic sclerosis (SSc). We investigated the contribution of CXCL6 to SSc development by focusing on the association of friend leukemia virus integration 1 (Fli1) deficiency, a potential predisposing factor of SSc, with CXCL6 expression and clinical correlation of serum CXCL6 levels.

    Methods: mRNA levels of target genes and the binding of Fli1 to the CXCL6 promoter were evaluated by quantitative reverse transcription-PCR and chromatin immunoprecipitation, respectively. Read More

    Infectious complications in chronic lymphocytic leukemia- a retrospective analysis: single institution experience.
    Neoplasma 2017 ;64(3):474-481
    The aim of this study was to evaluate the incidence of a variety of infectious complications in patients with CLL regarding the duration of CLL and the type of treatment. We present the retrospective analysis of patients with CLL treated at our institution in years 2004-2016. We collected data about the type of infection, pathogenes, treatment and severity of infections surpassed in connection with administration treatment. Read More

    Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation.
    Pediatr Transplant 2017 May 12. Epub 2017 May 12.
    Department of Pediatrics, Oita University Faculty of Medicine, Oita University, Oita, Japan.
    TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Read More

    RUNX transcription factors at the interface of stem cells and cancer.
    Biochem J 2017 May 10;474(11):1755-1768. Epub 2017 May 10.
    UCL Cancer Institute, University College London, London WC1E 6BT, U.K.
    The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes in RUNX1 are linked to loss of function classifying it broadly as a tumour suppressor. Despite this, several recent studies have reported the need for a certain level of active RUNX1 for the maintenance and propagation of acute myeloid leukaemia and acute lymphoblastic leukaemia cells, suggesting an oncosupportive role of RUNX1. Read More

    In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies.
    Sci Rep 2017 May 8;7(1):1526. Epub 2017 May 8.
    Departamento de Medicina Oncológica, Oncosalud-AUNA, Av. Guardia Civil 571, San Borja. Lima 41, Peru.
    DDIT4 gene encodes a protein whose main action is to inhibit mTOR under stress conditions whilst several in vitro studies indicate that its expression favors cancer progression. We have previously described that DDIT4 expression is an independent prognostic factor for tripe negative breast cancer resistant to neoadjuvant chemotherapy. We herein report that high DDIT4 expression is related to the outcome (recurrence-free survival, time to progression and overall survival) in several cancer types. Read More

    Adult T-cell leukemia-lymphoma complicated by Takotsubo cardiomyopathy and HTLV-1-associated myelopathy after treatment with the anti-CCR4 antibody mogamulizumab.
    Rinsho Ketsueki 2017 ;58(4):309-314
    Department of Hematology, Nippon Medical School.
    Adult T-cell leukemia-lymphoma (ATL) caused by human T-lymphotropic virus type 1 (HTLV-1) is generally associated with poor prognosis. The anti-CCR4 antibody mogamulizumab is one of the options for refractory or relapsed ATL. Mogamulizumab is intravenously administered as a single agent at a dose of 1. Read More

    Single-institutional retrospective analysis of Japanese patients with chronic lymphocytic leukemia.
    Rinsho Ketsueki 2017 ;58(4):282-286
    Division of Hematology, Department of Medicine, Keio University School of Medicine.
    Unlike in Western countries, chronic lymphocytic leukemia (CLL) is a rare lymphoid malignancy in Japan, and its clinical features remain to be elucidated in the Japanese population. Therefore, we retrospectively analyzed 29 Japanese CLL patients newly diagnosed at our institute. Seventeen (59%) were male, and their median age was 62 years. Read More

    The Use of FDG PET-CT Imaging for the Assessment of Early Antifungal Treatment Response in Disseminated Fusariosis.
    Clin Nucl Med 2017 May 6. Epub 2017 May 6.
    Department of Nuclear Medicine, Centre Cardiologique du Nord, Saint-Denis, France.
    Fusariosis is an opportunistic infection, caused by a filamentous fungus, found on plants and in soil. The treatment of disseminated pattern, seen in immunocompromised patients with severe neutropenia, is difficult because of antifungal therapy resistance. A 12-year-old girl, who was diagnosed with B-cell acute lymphoblastic leukemia, developed multiple widespread skin papules and subcutaneous nodules, at day 20 of consolidation therapy. Read More

    A case series of imatinib-induced generalized hypopigmentation and progression of existing acquired dermal melanocytosis.
    J Dermatolog Treat 2017 May 16:1-2. Epub 2017 May 16.
    a National Skin Center , Singapore.
    Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of oncological conditions, including chronic myeloid leukemia and gastrointestinal stromal tumors. The most frequent dermatological side effect reported is pigmentary abnormalities. We report a case series of three Asian Chinese females with preexisting acquired dermal melanocytosis that progressed after initiation of imatinib treatment, and concurrently developed generalized hypopigmentation of the skin. Read More

    Nodular Sclerodermatous Chronic Cutaneous Graft-Versus-Host Disease (GvHD): A New Clinicopathological Variant of Cutaneous Sclerodermatous GvHD Resembling Nodular/Keloidal Scleroderma.
    Am J Dermatopathol 2017 Apr 25. Epub 2017 Apr 25.
    *Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain;†Dermatopathology Research Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; and‡School of Pathology, University of Milan, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
    Cutaneous chronic graft-versus-host disease (GvHD) has a broad spectrum of clinicopathological presentations, the most common ones being poikiloderma, lichen planus-like eruptions, lichen sclerosus-like lesions, morphea-like plaques, and deep sclerosis. New forms of chronic cutaneous GvHD with different clinicopathological characteristics have been described, most of them mimicking cutaneous manifestations of autoimmune diseases. We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract. Read More

    A Study of Use of "PORT" Catheter in Patients with Cancer: A Single-Center Experience.
    Clin Med Insights Oncol 2017 23;11:1179554917691031. Epub 2017 Feb 23.
    Department of Medical & Pediatric Oncology, The Gujarat Cancer & Research Institute, Ahmedabad, India.
    Background: Effective and reliable venous access is one of the cornerstones of modern medical therapy in oncology.

    Materials And Methods: This is a prospective observational study, which collected data of patients who require "PORT" catheter insertion for any cancer, at a tertiary care oncology hospital in Ahmadabad, Gujarat, India, during a 2-year period.

    Aims And Objectives: The main objective of this study was to study the various complications and outcomes related to "PORT" catheters. Read More

    [Clinical Analysis for 42 Imatinib-resistant Patients with Chronic Myelogenous Leukemia].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Apr;25(2):377-381
    Department of Hematology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,Henan Province,China.
    Objective: To analyze the kinase mutation ratio, related factors, effectiveness and safety of the second generation drugs for imatinib-resistant patients with chronic myeloid leukemia(CML).

    Methods: COX proportional hazard regression model was used for unvariate and multvariate analysis of various factors affecting the kinase mutation and for evaluating the effectiveness and safety of second generation tyrosine kinase inhibitor(TKI).

    Results: 13 kinds of mutation were detected in 19 out of 42 cases for 22 times, including 4 times of F359V, 3 times of E255K, 2 time for F359C, F317L, T315I, Y253H, 1 time for D256R, C250R, D276G, F486S, M244V, Y256H and G250E, 3 cases with mixed mutations. Read More

    Generalized Palisaded Neutrophilic and Granulomatous Dermatitis-a cutaneous manifestation of Chronic Myelomonocytic Leukemia? A Clinical, Histopathological and Molecular Study of Three Cases.
    Hum Pathol 2017 Apr 22. Epub 2017 Apr 22.
    Department of Dermatology, University Hospital and Comprehensive Cancer Center Tuebingen, University of Tuebingen, 72076 Tuebingen. Electronic address:
    Palisaded neutrophilic and granulomatous dermatitis (PNGD) is characterized by erythematous papules or plaques on trunk or limbs and is frequently associated with rheumatological, autoimmune or hematological malignancies. Histopathology shows interstitial granulomas composed of epitheloid histiocytes in the reticular dermis with surrounding foci of collagen degeneration and variable neutrophilic inflammation. We report three cases of generalized PNGD associated with chronic myelomonocytic leukemia (CMML), a myelodysplastic/myeloproliferative neoplasm, which may show a variety of cutaneous manifestations. Read More

    Skin manifestations among GATA2-deficient patients.
    Br J Dermatol 2017 Apr 25. Epub 2017 Apr 25.
    Dermatology Department, CHU Rennes, Rennes, France.
    GATA2 mutations have been identified in various diseases, such as monoMAC syndrome, Emberger syndrome, familial myelodysplastic syndrome, acute myeloid leukemia, and dendritic cell, monocyte, B and NK cell deficiency. These syndromes present a wide range of clinical features, dominated by severe infections and haematological disorders such as myelodysplastic syndrome. Up to 70% of GATA2-mutated patients have dermatological features, mainly genital or extra-genital warts, panniculitis or erythema nodosum, and lymphedema. Read More

    The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-κB, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngodon idella).
    Fish Shellfish Immunol 2017 Jun 18;65:145-168. Epub 2017 Apr 18.
    Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
    This study was conducted to investigate the effects of dietary iron on the growth, and immune function and structural integrity in head kidney, spleen and skin as well as the underlying signaling of young grass carp (Ctenopharyngodon idella). Total 630 grass carp (242.32 ± 0. Read More

    Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature.
    Case Rep Dermatol Med 2017 23;2017:9359086. Epub 2017 Mar 23.
    Department of Dermatology, Loyola University Chicago, Chicago, IL, USA.
    Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used to treat imatinib-resistant chronic myelogenous leukemia (CML), as well as other Philadelphia chromosome-positive lymphoproliferative disorders. While the most commonly reported cutaneous side effects with this therapy include a morbilliform eruption, skin exfoliation, and skin irritation, pigmentary abnormalities have also been observed, albeit much more rarely. We present the case of a 72-year-old South Asian male with CML who presented with new-onset hypopigmentation of his face and scalp three years after a dose increase of dasatinib therapy, in the setting of newly discovered borderline hypovitaminosis D. Read More

    Morbidity and mortality after treatment of Ewing sarcoma: A single-institution experience.
    Pediatr Blood Cancer 2017 Apr 18. Epub 2017 Apr 18.
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Children, adolescents, and young adults treated for Ewing sarcoma (ES) are at risk for disease-related and treatment-related complications. We aimed to describe early and late overall mortality, cause-specific mortality, and key adverse health outcomes in a large, single-institutional cohort of patients with ES.

    Methods: Patients with ES diagnosed at age less than 40 years and treated at Memorial Sloan Kettering between 1974 and 2012 were included. Read More

    The Molecular Revolution in Cutaneous Biology: Era of Cytogenetics and Copy Number Analysis.
    J Invest Dermatol 2017 May;137(5):e57-e59
    Department of Dermatology, Eberhard Karls University, Tübingen, Germany. Electronic address:
    Development of karyotyping techniques in the 1950s sparked groundbreaking reports of chromosomal aberrations in cancer, such as the Philadelphia chromosome in chronic myelogenous leukemia in 1960, followed by a number of others. Spatial resolution of karyotyping is limited and vital tumor cells are required for metaphase preparation. To overcome these limitations, DNA hybridization techniques were developed. Read More

    The diagnosis and management of NK/T-cell lymphomas.
    J Hematol Oncol 2017 Apr 14;10(1):85. Epub 2017 Apr 14.
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.
    Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignancy of putative NK-cell origin, with a minority deriving from the T-cell lineage. Pathologically, the malignancy occurs in two forms, extranodal NK/T-cell lymphoma, nasal type; and aggressive NK-cell leukaemia. Lymphoma occur most commonly (80%) in the nose and upper aerodigestive tract, less commonly (20%) in non-nasal areas (skin, gastrointestinal tract, testis, salivary gland), and rarely as disseminated disease with a leukemic phase. Read More

    An Unfortunate Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Change (POEMS).
    Cureus 2017 Mar 8;9(3):e1086. Epub 2017 Mar 8.
    Internal Medicine, University of Central Florida College of Medicine.
    POEMS syndrome is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes, which is a rare paraneoplastic disease of monoclonal plasma cells. A mandatory criterion to diagnose POEMS syndrome is the presence of a monoclonal plasma cell dyscrasia in which plasma cell leukemia is the most aggressive form. Early identification of the features of the POEMS syndrome is critical for patients to identify an underlying plasma cell dyscrasias and to reduce the morbidity and mortality of the disease by providing early therapy. Read More

    Myeloid sarcoma causing airway obstruction.
    Proc (Bayl Univ Med Cent) 2017 Apr;30(2):195-196
    Department of Pathology (Belknap) and Division of Hematopathology (Krause), Baylor University Medical Center at Dallas and the Charles A. Sammons Cancer Center, Dallas, Texas.
    Myeloid sarcoma is an extramedullary collection of blasts of the myeloid series that partially or totally effaces the architecture of the tissue in which it is found. These tumors have been described in many sites of the body, but the skin, lymph nodes, gastrointestinal tract, bone, soft tissue, and testes are most common. They can arise in a patient following the diagnosis of acute myeloid leukemia, but they may also be precursors of leukemia and should be considered diagnostic for acute myeloid leukemia. Read More

    Hypocellular acute myeloid leukemia treated with bone marrow transplantation.
    Pediatr Int 2017 Apr;59(4):490-493
    Department of Pediatrics, St Marianna University School of Medicine Hospital, Kawasaki, Japan.
    Hypocellular acute myeloid leukemia (AML) mainly occurs in elderly patients, and is extremely rare in childhood. There is still no established treatment for hypocellular AML. We report the case of an 11-year-old boy with hypocellular AML who was treated successfully with allogenic bone marrow transplantation (allo-BMT). Read More

    Imatinib mesylate-induced lichenoid drug eruption.
    Cutis 2017 Mar;99(3):189-192
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA.
    Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Read More

    Phase I Study of Clofarabine and 2-Gy Total Body Irradiation as a Nonmyeloablative Preparative Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patients with Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia Consortium Study.
    Biol Blood Marrow Transplant 2017 Apr 7. Epub 2017 Apr 7.
    The Children's Hospital, TriStar Centennial and Sarah Cannon Research Institute, Nashville, Tennessee.
    Clofarabine is a purine nucleoside analog with immunosuppressive and antileukemic activity and its inclusion in reduced-intensity regimens could potentially improve outcomes. We performed a prospective phase I study of clofarabine combined with 2 Gy total body irradiation (TBI) as a nonmyeloablative preparative regimen for allogeneic stem cell transplantation in pediatric patients who were considered at high risk of mortality from standard myeloablative regimens. The main goal of the study was to delineate the maximum feasible dose (MFD) of clofarabine in combination with 2 Gy TBI. Read More

    DRUG-INDUCED ORAL ULCERATIONS: CASE REPORT.
    Acta Clin Croat 2016 Jun;55(2):334-7
    A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Read More

    eTumorType, An Algorithm of Discriminating Cancer Types for Circulating Tumor Cells or Cell-free DNAs in Blood.
    Genomics Proteomics Bioinformatics 2017 Apr 4;15(2):130-140. Epub 2017 Apr 4.
    National Research Council Canada, Montreal, QC H4P 2R2, Canada; Department of Experimental Medicine, McGill University, Montreal, QC H3A 2B2, Canada; Center for Bioinformatics, McGill University, Montreal, QC H3G 0B1, Canada; Center for Health Genomics and Informatics, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Department of Biochemistry & Molecular Biology, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Department of Medical Genetics, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Department of Oncology, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Alberta Children's Hospital Research Institute, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Research Institute, Calgary, AB T2N 4N1, Canada; O'Brien Institute for Public Health, Calgary, AB T2N 4N1, Canada. Electronic address:
    With the technology development on detecting circulating tumor cells (CTCs) and cell-free DNAs (cfDNAs) in blood, serum, and plasma, non-invasive diagnosis of cancer becomes promising. A few studies reported good correlations between signals from tumor tissues and CTCs or cfDNAs, making it possible to detect cancers using CTCs and cfDNAs. However, the detection cannot tell which cancer types the person has. Read More

    Aleukemic Myeloid Leukemia Cutis with a Kikuchi Disease-Like Inflammatory Pattern in Myelodysplastic Syndrome.
    South Med J 2017 Apr;110(4):308-313
    From the Departments of Pathology, Internal Medicine, and Hematology/Oncology, San Antonio Military Medical Center, Fort Sam Houston, and Dermatology, San Antonio Uniformed Services Health Education Consortium, Lackland Air Force Base, Lackland, Texas.
    Myeloid leukemia cutis (MLC) is a rare disease characterized by the infiltration of neoplastic myeloid, myelomonocytic, or monocytic precursors into the skin, producing clinically nonspecific-appearing papules, nodules, plaques, or purpura that necessitate biopsy for definitive diagnosis. In general, it is considered an extramedullary manifestation of acute myeloid leukemia (AML) similar to myeloid sarcoma, also known as a chloroma. MLC often develops in patients with an established diagnosis of AML and is only rarely seen before the onset of systemic disease. Read More

    A 3-Year-Old Girl with Recurrent Infections and Autoimmunity due to a STAT1 Gain-of-Function Mutation: The Expanding Clinical Presentation of Primary Immunodeficiencies.
    Front Pediatr 2017 17;5:55. Epub 2017 Mar 17.
    Allergy and Immunology Division, Hospital Nacional Edgardo Rebagliati Martins , Lima , Peru.
    We report a 3-year-old Peruvian girl, born to non-consanguineous parents. At the age of 8 months, she had a severe pneumonia complicated with empyema that required thoracic drainage and mechanical ventilation. Although no microorganisms were isolated, the patient recovered with broad-spectrum antibiotics. Read More

    The Construction and Identification of Induced Pluripotent Stem Cells Derived from Acute Myelogenous Leukemia Cells.
    Cell Physiol Biochem 2017 29;41(4):1661-1674. Epub 2017 Mar 29.
    Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.
    Objective: The present study aimed to establish an induced pluripotent stem cell (iPSC) line from acute myelogenous leukemia (AML) cells in vitro and identify their biological characteristics.

    Methods: Cells from the AML-infiltrated skin from an M6 patient were infected with a lentivirus carrying OCT4, SOX2, KLF4 and C-MYC to induce iPSCs. The characteristics of the iPSCs were confirmed by alkaline phosphatase (ALP) staining. Read More

    Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report.
    Mol Clin Oncol 2017 Feb 3;6(2):271-275. Epub 2017 Jan 3.
    Division of Hematology and Medical Oncology, Department of Medicine, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
    Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. Read More

    Chronic lymphocytic leukemia skin infiltration mimicking an ICD pocket infection: a case report.
    BMC Cardiovasc Disord 2017 Mar 24;17(1):89. Epub 2017 Mar 24.
    Department of Hematology, Ceske Budejovice Hospital, Ceske Budejovice, Czech Republic.
    Background: We are presenting a case report on an unreported and unusual cutaneous manifestation of chronic lymphocytic leukemia in a patient with an implantable cardioverter-defibrillator (ICD).

    Case Presentation: A 65-year-old man with a history of chronic lymphocytic leukemia (CLL), previously treated with chlorambucil, was referred in October 2013 for extraction of a single chamber ICD due to a suspected device-related infection in the pulse generator area (left-hand side of Fig. 1). Read More

    Purple patches in an immunocompromised patient: a report of secondary disseminated cutaneous mucormycosis in a man with chronic lymphocytic leukemia.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York.
    A 60-year-old man with chronic lymphocytic leukemiadeveloped a deeply violaceous annular patchwith a halo of erythema on the right thigh duringhospitalization for neutropenic fever. Associatedsymptoms included chronic cough and fatigue.Bilateral lung opacities with hilar lymphadenopathywere noted on chest computed tomographyscan. Read More

    Precursor-B-cell-ALL leukemia cutis resembling lipomas: an atypical presentation of a rare entity and a review of the literature.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Dermatology, Baylor College of Medicine, Houston, Texas.
    Leukemia cutis (LC) is an extramedullary manifestationof leukemia owing to cutaneous infiltration ofneoplastic cells resulting in characteristic firm,erythematous nodules. Most cases of LC occur inpatients with acute myelogenous leukemia andchronic myelogenous leukemia. However in rarecases, LC has presented in patients with acutelymphoblastic leukemia (ALL). Read More

    Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia.
    Tohoku J Exp Med 2017 03;241(3):201-208
    Division of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University.
    Adult T-cell leukemia/lymphoma (ATL/ATLL) is one of the most malignant lymphomas with poor prognosis. ATL/ATLL cells express CC chemokine receptor 4, and mogamulizumab (anti-CCR4 monoclonal antibody) exhibits strong cytotoxicity for ATL/ATLL cells. We analyzed plasma samples of 6 patients with ATL/ATLL treated with chemotherapy followed by mogamulizumab therapy (mogatherapy) for changes in the levels of biomarkers in relation to immune-related adverse effects. Read More

    [Bullous Sweet's syndrome with pulmonary involvement].
    Hautarzt 2017 Mar 16. Epub 2017 Mar 16.
    Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung , Juchgasse 25, 1030, Wien, Österreich.
    Acute febrile neutrophilic dermatosis (Sweet's syndrome) is a rare dermatosis characterized by painful papules and plaques accompanied by cutaneous infiltration with neutrophilic granulocytes. Bullous changes are observed in some cases. We report about a patient with osteomyelofibrosis who developed fever accompanied by painful plaques and confluent papules on both arms and thighs. Read More

    A Human Lin(-) CD123(+) CD127(low) Population Endowed with ILC Features and Migratory Capabilities Contributes to Immunopathological Hallmarks of Psoriasis.
    Front Immunol 2017 2;8:176. Epub 2017 Mar 2.
    Unidad de Investigación Médica en Inmunoquímica Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Mexico City , Mexico.
    Innate lymphoid cells (ILC) are members of a heterogeneous family with a lymphoid origin that mimics the T helper (Th) cytokine profile. ILC are involved in early effector cytokine-mediated responses during infections in peripheral tissues. ILC also play an important role in chronic skin inflammatory diseases, including psoriasis. Read More

    Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):45-47
    Hospital do Servidor Público Estadual de São Paulo (HSPE) - São Paulo (SP), Brazil.
    Tyrosine kinase inhibitors are effective as a target therapy for malignant neoplasms. Imatinib was the first tyrosine kinase inhibitor used. After its introduction, several other drugs have appeared with a similar mechanism of action, but less prone to causing resistance. Read More

    Runx Family Genes in Tissue Stem Cell Dynamics.
    Adv Exp Med Biol 2017 ;962:117-138
    Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
    The Runx family genes play important roles in development and cancer, largely via their regulation of tissue stem cell behavior. Their involvement in two organs, blood and skin, is well documented. This review summarizes currently known Runx functions in the stem cells of these tissues. Read More

    Clinicopathologic, Immunohistochemical, and Molecular Features of Histiocytoid Sweet Syndrome.
    JAMA Dermatol 2017 Mar 15. Epub 2017 Mar 15.
    Departments of Dermatology and Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
    Importance: Histiocytoid Sweet syndrome is a rare histopathologic variant of Sweet syndrome. The nature of the histiocytoid infiltrate has generated considerable controversy in the literature.

    Objective: The main goal of this study was to conduct a comprehensive overview of the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome. Read More

    Coffee and cancer risk: a summary overview.
    Eur J Cancer Prev 2017 Mar 10. Epub 2017 Mar 10.
    aDepartment of Clinical Sciences and Community Health, University of Milan bDepartment of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.
    We reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016. Coffee consumption is not associated with overall cancer risk. A meta-analysis reported a pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1. Read More

    [Fungemia and septic arthritis caused by Saprochaete capitata in a patient with fanconi aplastic anemia: a case report].
    Mikrobiyol Bul 2017 Jan;51(1):87-93
    Erciyes University Faculty of Medicine, Department of Medical Microbiology, Kayseri, Turkey.
    Saprochaete capitata (formerly known as Blastoschizomyces capitatus, Trichosporon capitatum, Geotrichum capitatum) is a rare but emerging yeast-like fungus. It is commonly found in environmental sources and can be isolated from skin, gastrointestinal system and respiratory tract of healthy individuals as well. It mainly infects patients with hematological malignancies such as acute myeloid leukemia (AML), especially in the presence of neutropenia; and mortality rates are high in those patients. Read More

    Hodgkin Lymphoma in a Case of Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitors.
    Turk Patoloji Derg 2017 Feb 4. Epub 2017 Feb 4.
    Department of Pathology & Laboratory Medicine, Medanta the Medicity, GURGAON, INDIA.
    Chronic myeloid leukemia (CML) is characterized by increased and unregulated proliferation of granulocytic lineage in the bone marrow and presence of these immature myeloid cells in the peripheral blood with presence of Philadelphia (Ph) chromosome. Tyrosine kinase inhibitors are the most important drugs in the CML therapy and provide long disease-free survival. Due to the increased survival of CML patients with continual administration of these drugs, the chance of development of secondary malignancies may increase. Read More

    Subcutaneous Leiomyosarcoma Metastasized to the Lymph Nodes Involved with Small Lymphocytic Lymphoma / Chronic Lymphocytic Leukemia.
    Turk Patoloji Derg 2017 Feb 4. Epub 2017 Feb 4.
    Department of General Surgery, Ondokuz Mayıs University, Faculty of Medicine, SAMSUN, TURKEY.
    Herein, we present a case of a 76-year-old Caucasian man with a very large fungating, ulcerating mass, involving the right neck and parotid area, which developed while he was being treated for chronic lymphocytic leukemia/small lymphocytic lymphoma. Resection of the fungating right neck tumor, right modified radical neck dissection, and right superficial parotidectomy with flap reconstruction were performed. The final pathological diagnosis was high-grade leiomyosarcoma of the skin and the subcutaneous tissue, with invasion into the skeletal muscle, skin, and soft tissue. Read More

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