9,223 results match your criteria Leukemia Cutis


CADM1 is a diagnostic marker in early-stage mycosis fungoides: Multicenter study of 58 cases.

J Am Acad Dermatol 2018 Jun 18. Epub 2018 Jun 18.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences. Electronic address:

Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene in human non-small-cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma (ATLL). Read More

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June 2018
1 Read

Study of Complications of Varicella-Zoster Virus Infection in Hospitalized Children at a Reference Hospital for Infectious Disease Treatment.

Hosp Pediatr 2018 Jun 19. Epub 2018 Jun 19.

School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Objectives: Varicella is a disease with potentially severe complications. We aimed to investigate characteristics of hospitalized children with varicella in Brazil in the prevaccine period and to identify predictors for requiring intensive care treatment.

Methods: A prospective cohort study was conducted from May 2011 to April 2014. Read More

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New Therapies and Immunological Findings in Cutaneous T-Cell Lymphoma.

Authors:
Kazuyasu Fujii

Front Oncol 2018 4;8:198. Epub 2018 Jun 4.

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Read More

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June 2018
3 Reads

Cutaneous involvement in an 8-year-old boy with Ras-associated autoimmune leucoproliferative disorder (RALD).

Clin Exp Dermatol 2018 Jun 16. Epub 2018 Jun 16.

Dermatology Department, Hospital Universitari Son Espases, Palma de Mallorca, Spain.

Ras-associated autoimmune leucoproliferative disorder (RALD) is a nonmalignant syndrome associated with somatic KRAS mutations. We report a patient with RALD and cutaneous lesions, the first such case reported, to our knowledge. An 8-year-old boy presented with erythematous plaques on his face and body, along with lymphadenopathies and spleen enlargement without systemic symptoms. Read More

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Health and Ecological Aspects of Stray Cats in Old San Juan, Puerto Rico: Baseline Information to Develop an Effective Control Program.

P R Health Sci J 2018 Jun;37(2):110-114

Department of Environmental Science, University of Puerto Rico Rio Piedras Campus, San Juan, PR.

The overpopulation of stray cats in urban areas represents a potential risk for humans, as stray cats may carry diseases, such as toxoplasmosis, and virus such as rabies, the feline immunodeficiency, and the feline leukemia. In Old San Juan, a historic neighborhood and one of the most touristic places in Puerto Rico, there is an overpopulation of stray cats. In this study, we generated baseline information fundamental to developing a successful control program by estimating the stray cat population size, density, and spatial distribution. Read More

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Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis.

Sci Rep 2018 Jun 13;8(1):9074. Epub 2018 Jun 13.

Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Read More

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FOXP3-positive T-cell lymphomas in non-HTLV1 carriers include ALK-negative anaplastic large cell lymphoma: expanding the Spectrum of T-cell lymphomas with regulatory phenotype.

Hum Pathol 2018 Jun 10. Epub 2018 Jun 10.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56years with a male predominance. Read More

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Squamoid eccrine ductal carcinoma.

Cutis 2018 May;101(5):378;380;385

Hartford Dermatology Associates, West Hartford, Connecticut, USA.

Squamoid eccrine ductal carcinoma (SEDC) is an extremely rare cutaneous tumor of unknown etiology. We report the case of a 77-year-old man with a history of treated chronic lymphocytic leukemia along with numerous basal cell and squamous cell carcinomas who presented for evaluation of a 5-cm, stellate, sclerotic plaque on the left chest of approximately 2 years' duration and a suspicious 3-mm pink papule on the right nasal sidewall of 2 months' duration. Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation that extended from the undersurface of the epidermis, favoring a diagnosis of SEDC. Read More

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Incidence of cancer (other than gastric cancer) in pernicious anaemia: A systematic review with meta-analysis.

Dig Liver Dis 2018 May 24. Epub 2018 May 24.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sapienza University of Rome, Italy.

Background: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers.

Aim: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC.

Methods: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017). Read More

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May 2018
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Buccal paraneoplastic pemphigus multi-resistant: Case report and review of diagnostic and therapeutic strategies.

J Stomatol Oral Maxillofac Surg 2018 Jun 8. Epub 2018 Jun 8.

Department of oral and maxillofacial surgery, cliniques universitaires Saint-Luc, université catholique de Louvain, avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.

Paraneoplastic pemphigus is a rare autoimmune blistering disease generally associated with malignancy. The clinical presentation consists typically of painful and diffuse erosive stomatitis that may be accompanied by polymorphic skin lesions and systemic involvement. Diagnosis is based on clinical manifestations and confirmed by histology and immunological testing. Read More

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June 2018
3 Reads

Atypical presentation of blastic plasmacytoid dendritic cell neoplasm: A potential diagnostic pitfall in nasal cavity.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 May 3. Epub 2018 May 3.

Department of Pathology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China. Electronic address:

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease with an aggressive clinical course resulting in median survival times of 12 to 14 months. It represents approximately 0.8% of primary cutaneous lymphomas. Read More

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Non-pseudomonal Ecthyma Gangrenosum and Idiopathic Myelofibrosis in a Two-Year-Old Girl.

Cureus 2018 Apr 6;10(4):e2441. Epub 2018 Apr 6.

Department of Internal Medicine, Civil Hospital Karachi, Dow University of Health Sciences (DUHS), Karachi, PAK.

Ecthyma gangrenosum is a skin lesion consequent to bacteremia, mostly due to Pseudomonas aeruginosa, although it may develop secondary to other organisms as well. The disease is often witnessed in patients with leukemia; however, a few cases of ecthyma gangrenosum in adults were reported to be associated with myelofibrosis. We report a case of ecthyma gangrenosum due to Escherichia coli (E. Read More

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April 2018
2 Reads

Ontology-based literature mining and class effect analysis of adverse drug reactions associated with neuropathy-inducing drugs.

J Biomed Semantics 2018 Jun 7;9(1):17. Epub 2018 Jun 7.

Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Background: Adverse drug reactions (ADRs), also called as drug adverse events (AEs), are reported in the FDA drug labels; however, it is a big challenge to properly retrieve and analyze the ADRs and their potential relationships from textual data. Previously, we identified and ontologically modeled over 240 drugs that can induce peripheral neuropathy through mining public drug-related databases and drug labels. However, the ADR mechanisms of these drugs are still unclear. Read More

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Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.

J Clin Oncol 2018 Jun 6:JCO2017767764. Epub 2018 Jun 6.

Lucie M. Turcotte, Joseph P. Neglia, University of Minnesota Medical School, Minneapolis, MN; Raoul C. Reulen, University of Birmingham, Birmingham, UK; Cecile M. Ronckers, Dutch Childhood Oncology Group Long-term Effects After Childhood Cancer Consortium, The Hague; Flora E. van Leeuwen, Netherlands Cancer Institute, Amsterdam, the Netherlands; Lindsay M. Morton, National Institutes of Health, Bethesda, MD; David C. Hodgson, University of Toronto, Toronto, Canada; Yutaka Yasui, St Jude Children's Research Hospital, Memphis, TN; Kevin C. Oeffinger, Duke University, Durham, NC; and Tara O. Henderson, University of Chicago Comer Children's Hospital, Chicago, IL.

Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Survivors of childhood cancer experience long-term increased SMN risk compared with the general population, with a greater than twofold increased solid tumor risk extending beyond age 40 years. Read More

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June 2018
2 Reads

Lenalidomide Induced Toxic Epidermal Necrolysis and Del (5q): Co-occurrence of Rarities.

J Coll Physicians Surg Pak 2018 Jun;28(6):S89-S90

Department of Hematology, Armed Forces Bone Marrow Transplant Centre, Rawalpindi.

Primary myelofibrosis (PMF) is a clonal, BCR-ABL1 negative myeloproliferative neoplasm characterised by splenomegaly, leukoerythroblastic peripheral blood picture and bone marrow fibrosis. Different cytogentic abnormalities are documented in PMF which have impact on clinical outcome and overall survival. Del 5q31 is documented in only 0. Read More

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Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study.

Ann Hematol 2018 Jun 4. Epub 2018 Jun 4.

Department of Internal Medicine III with Hematology and Medical Oncology, Oncologic Center, Paracelsus Medical University Salzburg, Müllner-Hauptstr. 48, 5020, Salzburg, Austria.

Despite recent advances, chemoimmunotherapy remains a standard for fit previously untreated chronic lymphocytic leukaemia patients. Lenalidomide had activity in early monotherapy trials, but tumour lysis and flare proved major obstacles in its development. We combined lenalidomide in increasing doses with six cycles of fludarabine and rituximab (FR), followed by lenalidomide/rituximab maintenance. Read More

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June 2018
1 Read

Pityriasis rubra pilaris-like erythroderma secondary to phosphoinositide 3-kinase inhibition.

Clin Exp Dermatol 2018 May 30. Epub 2018 May 30.

Department of Dermatology, The Center for Cutaneous Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.

Background: Phosphoinositide 3-kinase (PI3K) inhibitors are a class of small-molecule inhibitors approved for the treatment of certain leukaemias and lymphomas. Their dermatological adverse event profile is poorly described.

Aim: To characterize a rare cutaneous adverse event from PI3K inhibitors in order to help dermatologists and oncologists identify and effectively manage such eruptions. Read More

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May 2018
2 Reads

Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells.

Mol Med Rep 2018 May 22. Epub 2018 May 22.

Department of Biological Science, Sookmyung Women's University, Seoul 04310, Republic of Korea.

Atopic dermatitis (AD) is a type of chronic skin inflammation and one of the most common relapsing allergic diseases, which presents with a severe rash and itchy skin lesions. The pathogenesis of AD is primarily associated with hyper‑activated mast cells, which makes them an effective treatment target. After cross‑linking the antigen/immunoglobulin (Ig) E complex binds to its high affinity receptor FcεRl on the surface of mast cells. Read More

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Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain.

Nat Prod Res 2018 May 29:1-5. Epub 2018 May 29.

a Faculty of Pharmacy, Department of Pharmacology , University of Seville , Sevilla , Spain.

Since plants are an important source of anticancer drugs, we have carried out a random screening for selective anticancer activity of 57 extracts from 45 plants collected in Grazalema Natural Park, an area in the South of Spain of high plant diversity and endemism. Using lung cancer cells (A549) and lung non-malignant cells (MRC-5), we found that several extracts were more cytotoxic and selective against the cancer cells than the standard anticancer agent cisplatin. Five active extracts were further tested in cancer and normal cell lines from other tissues, including three skin cell lines with increasing degree of malignancy. Read More

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May 2018
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Neonatal leukaemia.

Br J Haematol 2018 May 28. Epub 2018 May 28.

St Mary's Hospital campus of Imperial College London, St Mary's Hospital, London, UK.

Neonatal leukaemia is defined as occurring within the first 28 days of life and most, if not all, cases are congenital. With the exception of Down syndrome-associated transient abnormal myelopoiesis, which is not considered here, neonatal leukaemias are rare. In two-thirds of patients the disease manifests as an acute myeloid leukaemia, frequently with monocytic/monoblastic characteristics. Read More

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May 2018
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Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response.

Leukemia 2018 May 23. Epub 2018 May 23.

Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare skin-tropic hematological malignancy of uncertain pathogenesis and poor prognosis. We examined 118 BPDCN cases for cytomorphology, MYC locus rearrangement, and MYC expression. Sixty-two (53%) and 41 (35%) cases showed the classic and immunoblastoid cytomorphology, respectively. Read More

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May 2018
3 Reads

Oncogenomic analysis identifies novel biomarkers for tumor stage mycosis fungoides.

Medicine (Baltimore) 2018 May;97(21):e10871

Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College.

Patients with mycosis fungoides (MF) developing tumors or extracutaneous lesions usually have a poor prognosis with no cure has so far been available. To identify potential novel biomarkers for MF at the tumor stage, a genomic mapping of 41 cutaneous lymphoma biopsies was used to explore for significant genes.The gene expression profiling datasets of MF were obtained from Gene Expression Omnibus database (GEO). Read More

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May 2018
3 Reads

Prevalence of CD30 immunostaining in neoplastic mast cells: A retrospective immunohistochemical study.

Medicine (Baltimore) 2018 May;97(21):e10642

UMR U.1037, Centre de recherche sur cancer de Toulouse, Université Paul-Sabatier.

Mastocytosis is a rare disease characterized by clonal neoplastic proliferation of mast cells (MCs). It ranges from skin lesions as cutaneous mastocytosis (CM) which may spontaneously regress to highly aggressive neoplasms with multiorgan involvement corresponding to some aggressive systemic mastocytosis (ASM), mast cell leukemia (MCL), and/or mast cell sarcoma (MCS).There is increasing evidence of CD30 expression in neoplastic MCs of the bone marrow. Read More

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May 2018
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Hypersensitivity to alemtuzumab. A safe and effective desensitization protocol: A case report.

J Oncol Pharm Pract 2018 Jan 1:1078155218775473. Epub 2018 Jan 1.

7 Unidad de Reumatología. UGC Cirugía Ortopédica, Traumatología y Reumatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.

We describe a successful desensitization to alemtuzumab in one patient diagnosed with T-cell prolymphocytic leukaemia. Alemtuzumab treatment was initiated during infusion number 18, the patient showed cutaneous eruption with a miliary pattern, despite premedication with corticosteroids and antihistamines. The eruption returned with successive alemtuzumab infusions (infusions 19, 20 and 21), remained present for longer and was more severe with each infusion. Read More

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January 2018

Peanut flour aggregation with polyphenolic extracts derived from peanut skin inhibits IgE binding capacity and attenuates RBL-2H3 cells degranulation via MAPK signaling pathway.

Food Chem 2018 Oct 3;263:307-314. Epub 2018 May 3.

Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina 28081, USA. Electronic address:

This study investigates the anti-allergic properties of peanut skin polyphenols (PSP)-enriched peanut (PN) protein aggregates. PSP was blended with PN flour at concentrations of 5, 10, 15, 30, and 40% (w/w). Rat basophil leukemia cells (RBL-2H3) were sensitized with either anti-DNP-IgE or PN-allergic plasma followed by co-exposure to unmodified PN flour (control) or PSP-PN protein aggregates and Ca ionophore, ionomycin. Read More

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October 2018

Nanosized ethanol based malleable liposomes of cytarabine to accentuate transdermal delivery: formulation optimization, in vitro skin permeation and in vivo bioavailability.

Artif Cells Nanomed Biotechnol 2018 May 17:1-13. Epub 2018 May 17.

a Institute of Pharmaceutical Sciences , Guru Ghasidas Vishwavidyalaya (A Central University) , Bilaspur , C.G. , India.

Cytarabine is a pyrimidine nucleoside analog used predominantly for acute myeloid leukemia (AML) and also for other indications, including acute lymphocytic leukemia, chronic myelogenous leukemia, and lymphoma by parenteral route due to its low oral bioavailability. Parenteral administration requires constant plasma level, monitoring for its fluctuation and poor patients compliances. Hence the objective of this work is to construct optimized nanosized malleable liposomes of cytarabine to accentuate transdermal delivery of drug to circumvent previously mentioned drawbacks. Read More

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Insights into Mutation Effect in Three Poikiloderma with Neutropenia Patients by Transcript Analysis and Disease Evolution of Reported Patients with the Same Pathogenic Variants.

J Clin Immunol 2018 May 16. Epub 2018 May 16.

Laboratorio di Citogenetica Medica e Genetica Molecolare, Centro di Ricerche e Tecnologie Biomediche IRCCS-Istituto Auxologico Italiano, Via Ariosto 13, 20145, Milan, Italy.

Purpose: Poikiloderma with neutropenia (PN) is a genodermatosis currently described in 77 patients, all presenting with early-onset poikiloderma, neutropenia, and several additional signs. Biallelic loss-of-function mutations in USB1 gene are detected in all molecularly tested patients but genotype-phenotype correlation remains elusive. Cancer predisposition is recognized among PN features and pathogenic variants found in patients who developed early in life myelodysplasia (n = 12), acute myeloid leukemia (n = 2), and squamous cell carcinoma (n = 2) should be kept into account in management and follow-up of novel patients. Read More

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PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.

Mol Pharmacol 2018 Jul 16;94(1):784-792. Epub 2018 May 16.

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York

Arsenic is a naturally occurring, ubiquitous metalloid found in the Earth's crust. In its inorganic form, arsenic is highly toxic and carcinogenic and is widely found across the globe and throughout the environment. As an International Agency for Research on Cancer-defined class 1 human carcinogen, arsenic can cause multiple human cancers, including liver, lung, urinary bladder, skin, kidney, and prostate. Read More

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July 2018
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[Clinical and laboratory characteristics of juvenile myelomonocytic leukemia].

Zhongguo Dang Dai Er Ke Za Zhi 2018 May;20(5):373-377

Department of Clinical Laboratory, Children′s Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To study the clinical and laboratory characteristics of juvenile myelomonocytic leukemia (JMML).

Methods: The clinical characteristics and laboratory results were retrospectively analyzed in 10 children with newly diagnosed JMML. They were compared with those of 28 children with myelodysplastic syndrome (MDS) and 44 children with chronic myeloid leukemia (CML). Read More

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Stevens-Johnson Syndrome associated with methotrexate treatment for acute lymphoblastic leukemia: a case report.

Arch Argent Pediatr 2018 06;116(3):e459-e462

Ege University Faculty of Medicine, Department of Pediatrics, Division of Hematology, İzmir, Turkey.

Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare mucocutaneous diseases which are associated with a prolonged course and potentially lethal outcome. They are mostly drug induced and mortality rates are very high. Although mostly skin is involved, multiple organ systems such as cardiovascular, pulmonary, gastrointestinal, and urinary systems may be affected. Read More

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June 2018
2 Reads

Recurrent and Fixed Neutrophilic Dermatosis Associated With Dasatinib.

J Cutan Med Surg 2018 May 1:1203475418775663. Epub 2018 May 1.

4 Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Background: Dasatinib is a tyrosine kinase inhibitor indicated for the treatment of chronic myeloid leukemia (CML). Skin rashes are common, occurring in about a quarter of patients treated, and are generally mild. The commonest rash is a keratosis pilaris-like eruption. Read More

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Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties.

Phytomedicine 2018 Apr 19;43:21-27. Epub 2018 Mar 19.

Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural product that is used mainly as a food coloring and flavoring agent. Three main secondary metabolites of Crocus sativus including crocin, picrocrocin, and safranal are responsible for the color, the bitter taste and for the odor and aroma, respectively. Read More

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April 2018
3 Reads

Nanoencapsulation of Cyanidin-3- O-glucoside Enhances Protection Against UVB-Induced Epidermal Damage through Regulation of p53-Mediated Apoptosis in Mice.

J Agric Food Chem 2018 May 17;66(21):5359-5367. Epub 2018 May 17.

Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection , Jinan University , Guangzhou , China.

Excess ultraviolet (UV) radiation causes numerous forms of skin damage. The aim of the present study was to assess and compare the photoprotective effects of cyanidin-3- O-glucoside (C3G) alone and encapsulated in chitosan nanoparticles (Nano-C3G) in a UVB-induced acute photodamage mouse model. Nano-C3G was developed from chitosan and sodium tripolyphosphate (TPP) by ionic gelation. Read More

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May 2018
2 Reads

Connecting the Dots: A Case of Myeloid Sarcoma.

Am J Med 2018 May 3. Epub 2018 May 3.

Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, Fla.

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Cutaneous herald: leukaemia cutis as presenting manifestation of relapse in acute promyelocytic leukaemia.

BMJ Case Rep 2018 May 2;2018. Epub 2018 May 2.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Leukaemia cutis or cutaneous infiltration of neoplastic myeloid or lymphoid cells is usually seen in the acute myelomonocytic and acute monocytic variants of acute myeloid leukaemia. Here, we report a case of acute promyelocytic leukaemia who achieved remission, presenting with skin lesions, the biopsy of which revealed leukaemia cutis, heralding the relapse of the disease. After establishing the diagnosis with bone marrow analysis, the patient was started on daunorubicin chemotherapy along with arsenic trioxide and all-trans retinoic acid. Read More

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May 2018
6 Reads

J Mycol Med 2018 Jun 1;28(2):390-392. Epub 2018 May 1.

Post-Graduate program in Medical Science, Federal University of Ceará, Fortaleza, Ceará, Brazil; Clinical Medicine Department, Federal University of Ceará, Fortaleza, Ceará, Brazil; Patology and Legal Medicine Department, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Severely immunocompromised patients are at increased risk for uncommon infectious diseases with atypical presentations. Fusarium sp., has been reported in patients with hematological malignancies and prompt diagnosis is necessary due to high mortality. Read More

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June 2018
1 Read

Clinical and pathological features of myeloid leukemia cutis.

An Bras Dermatol 2018 Mar;93(2):216-221

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Sciences, Beijing, China.

Background: Myeloid leukemia cutis is the terminology used for cutaneous manifestations of myeloid leukemia.

Objective: The purpose of this study was to study the clinical, histopathological and immunohistochemical features of myeloid leukemia cutis.

Methods: This was a retrospective study of clinical and pathological features of 10 patients with myeloid leukemia cutis. Read More

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Postherpetic isotopic responses with 3 simultaneously occurring reactions following herpes zoster.

Cutis 2018 Mar;101(3):195-197

Department of Dermatology, University of California, San Francisco, USA.

Inflammatory, infectious, and neoplastic processes can all occur in prior areas of herpes infection (postherpetic isotopic response [PHIR]). Postzoster granulomatous dermatitis is among the most frequently encountered PHIR, but the exact pathogenesis has not been fully elucidated. Rarely, multiple diseases manifest concurrently in a PHIR. Read More

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Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cells.

J Ethnopharmacol 2018 Aug 27;222:21-33. Epub 2018 Apr 27.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

Ethnopharmacological Relevance: Recommendations have been made stating that ethnopharmacological usages such as immune and skin disorders, inflammatory, infectious, parasitic and viral diseases should be taken into account if selecting plants for anticancer screening, since these reflect disease states bearing relevance to cancer or cancer-like symptoms. Cameroonian medicinal plants investigated in this work are traditionally used to treat cancer or ailments with relevance to cancer or cancer-like symptoms.

Aim Of The Study: In this study, 21 methanol extracts from 18 Cameroonian medicinal plants were tested in leukemia CCRF-CEM cells, and the best extracts were further tested on a panel of human cancer cell lines, including various multi-drug-resistant (MDR) phenotypes. Read More

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August 2018
2 Reads

Refining the phenotype associated with biallelic DNAJC21 mutations.

Clin Genet 2018 Apr 26. Epub 2018 Apr 26.

Service de Génétique Médicale, CHU Sainte-Justine, Montréal, Canada.

Inherited bone marrow failure syndromes (IBMFS) are caused by mutations in genes involved in genomic stability. Although they may be recognized by the association of typical clinical features, variable penetrance and expressivity are common, and clinical diagnosis is often challenging. DNAJC21, which is involved in ribosome biogenesis, was recently linked to bone marrow failure. Read More

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Meta-analysis of the incidence and patterns of second neoplasms after photon craniospinal irradiation in children with medulloblastoma.

Pediatr Blood Cancer 2018 Apr 25:e27095. Epub 2018 Apr 25.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Second neoplasms (SNs) are a well-established long-term adverse effect of radiation therapy (RT), but there are limited data regarding their incidence and location relative to the radiation field, specific to medulloblastoma (MB) survivors after craniospinal irradiation (CSI).

Methods: A systematic literature review, per Preferred Reporting Items for Systematic Reviews and Meta-Analyses, identified six studies reporting the incidence and locations of SNs for 1,114 patients with MB, after CSI, with a median follow-up of ∼9 years (7.6-15. Read More

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Myeloid sarcoma with megakaryoblastic differentiation presenting as a breast mass.

Hematol Oncol Stem Cell Ther 2018 Apr 17. Epub 2018 Apr 17.

Department of Pathology, Medstar Georgetown University Hospital, Washington, D.C. 20007, United States.

Myeloid sarcoma is an extramedullary tumor that consists of myeloblasts or immature myeloid cells. The neoplasm can occur in any part of the body, including the bone, periosteum, lymph nodes, skin, and soft tissue and they may occur de novo or in association with acute myeloid leukemia, myeloproliferative neoplasms and myelodysplastic syndromes. Most cases display a myelomonocytic or pure monoblastic morphology. Read More

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Genital ulcers as diagnostic clue for acute myeloid leukaemia.

Int Wound J 2018 Apr 23. Epub 2018 Apr 23.

Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.

Acute myeloid leukaemia is a myeloid neoplasm with an extremely varying clinical appearance. Skin lesions are common for specific subtypes of acute myeloid leukaemia but are often misinterpreted. Here, we present a case of acute myeloid leukaemia in a young woman exhibiting genital ulcerations and gingival erosions. Read More

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Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases.

Case Rep Hematol 2018 28;2018:9191582. Epub 2018 Feb 28.

Moffitt Cancer Center, Tampa, FL, USA.

Nonhepatosplenic/noncutaneous peripheral T-cell lymphoma (NHNC PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNC PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Read More

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February 2018
2 Reads

D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.

Case Rep Hematol 2018 18;2018:3890361. Epub 2018 Feb 18.

Serviço de Hematologia Clínica, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.

Introduction: Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute myeloblastic leukemia (AML).

Case Report: A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and diarrhea. Read More

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February 2018
1 Read

Review: Risks of disease transmission through semen in cattle.

Authors:
M D Givens

Animal 2018 Jun 18;12(s1):s165-s171. Epub 2018 Apr 18.

1College of Veterinary Medicine,Auburn University,Auburn,AL 36849-5536,USA.

The purpose of this paper is to review scientific evidence concerning pathogens that could potentially be transmitted via bovine semen. As a result of a careful analysis of the characteristics of infections that may cause transmission of disease through semen, effective control procedures can be identified that provide minimal constraint to the introduction of new bulls into herds for natural breeding and importation of valuable novel genetics through artificial insemination. The potential for transmission through bovine semen and corresponding effective control procedures are described for bovine herpesvirus 1, bovine viral diarrhea virus, bovine leukemia virus, lumpy skin disease virus, bluetongue virus, foot-and-mouth disease virus, and Schmallenberg virus. Read More

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June 2018
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Vitiligo type cutaneous manifestation of chronic graft-versus-host disease. Case report.

Rev Chil Pediatr 2018 Feb;89(1):113-117

Departamento de Anatomía Patológica, Hospital Dr. Luis Calvo Mackenna, Santiago, Chile.

Introduction: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation. Read More

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February 2018
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A characteristic flow cytometric pattern with broad forward scatter and narrowed side scatter helps diagnose immune thrombocytopenia (ITP).

Int J Hematol 2018 Apr 16. Epub 2018 Apr 16.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.

Various disorders cause severe thrombocytopenia, which can lead to critical hemorrhage. Procedures that rapidly support the diagnosis and risk factors for serious bleeding were explored, with a focus on immune thrombocytopenia (ITP). Twenty-five patients with thrombocytopenia, including 13 with newly diagnosed ITP, 3 with chronic ITP, 6 with aplastic anemia (AA), and 3 with other thrombocytopenia (one acute myeloid leukemia, one acute lymphoblastic leukemia, and one hemophagocytic lymphohistiocytosis), were reviewed. Read More

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April 2018
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Cutaneous presentation of adult T-cell leukemia/lymphoma (ATLL). Single-center study on 37 patients in metropolitan France between 1996 and 2016.

Ann Dermatol Venereol 2018 Jun - Jul;145(6-7):405-412. Epub 2018 Apr 14.

Dermatology department, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France; Inserm Unité 976, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris-Diderot, Sorbonne-Paris-Cité, 75000 Paris, France.

Introduction: Adult T-cell leukemia/lymphoma (ATLL) is a hematological malignancy associated with chronic HTLV-1 infection.

Aim: To describe skin lesions in ATLL.

Methods: A descriptive, retrospective study between 1996 and 2016, including all patients diagnosed with ATLL at Saint-Louis Hospital (Paris, France). Read More

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April 2018
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Cutaneous presentation preceding acute myeloid leukemia with CD4+/CD56+ expression misdiagnosed as a blastic plasmocytoid dendritic cell neoplasm: A case report.

J Cutan Pathol 2018 Apr 16. Epub 2018 Apr 16.

Département d'Hématologie Biologique, CHU Montpellier, Montpellier, France.

Acute myeloid leukemia (AML) may initially present as cutaneous lesions corresponding to blasts involving the skin as the first clinical manifestation prior to blood and bone marrow (BM) infiltration. Such presentation is known as myeloid leukemia cutis (LC). Blastic plasmocytoid dendritic cell neoplasm (BPDCN) is an aggressive tumor derived from the precursors of plasmocytoid dendritic cells with cutaneous and BM involvement and leukemic dissemination. Read More

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April 2018
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