314,668 results match your criteria Leukemia & Lymphoma[Journal]


Adipokines Regulate the Expression of Tumor-Relevant MicroRNAs.

Obes Facts 2019 Apr 18;12(2):211-225. Epub 2019 Apr 18.

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Increasing prevalence of obesity requires the investigation of respective comorbidities, including tumor diseases like colorectal, renal, post-menopausal breast, prostate cancer, and leukemia. To date, molecular mechanisms of the malignant transformation of these peripheral tissues induced by obesity remain unclear. Adipose tissue secretes factors with hormone-like functions, the adipokines, and is therefore categorized as an endocrine organ. Read More

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http://dx.doi.org/10.1159/000496625DOI Listing

Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk).

Eur J Med Chem 2019 Mar 26;173:167-183. Epub 2019 Mar 26.

State Key Laboratory of Chemical Oncogenomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, 518055, China. Electronic address:

Interleukin-2-inducible T-cell kinase (Itk) plays an important role in multiple signal transduction pathways in T and mast cells, and is a potential drug target for treating inflammatory diseases, autoimmune diseases, and T cell leukemia/lymphoma. Herein, we describe the discovery of a series of covalent Itk inhibitors based on the 7H-pyrrolo[2,3-d]pyrimidine scaffold. Placing an appropriate substitution group at a hydration site of the ATP binding pocket of Itk and using a saturated heterocyclic ring as a linker to the reactive group were crucial for selectivity. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.055DOI Listing

HIV co-infection in HTLV-1 carriers in Spain.

Virus Res 2019 Apr 15. Epub 2019 Apr 15.

UNIR Health Sciences School & Medical Center, Madrid, Spain. Electronic address:

Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681702193017
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http://dx.doi.org/10.1016/j.virusres.2019.04.004DOI Listing
April 2019
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Frequency of hematologic and solid malignancies in the family history of 50 patients with acute myeloid leukemia - a single center analysis.

PLoS One 2019 18;14(4):e0215453. Epub 2019 Apr 18.

Department of Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich-Campus Großhadern, Munich, Germany.

Background And Objective: The revised World Health Organization classification of 2016 for myeloid neoplasms and acute leukemia added a section of myeloid neoplasms with germline predisposition. The main objective of our study was to evaluate the frequency of hematologic and solid malignancies in the family history of patients with acute myeloid leukemia (AML) by using a systemic pedigree interview. The family history was taken of 50 patients between 24 and 80 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215453PLOS

[Recent Advances in Immunotherapy for Acute Myeloid Leukemia --Review].

Authors:
Bin Xu Yi Xiao

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):633-636

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China E-mail:

Currently, the traditional chemotherapeutic drugs for acute myeloid leukemia (AML) showed significant curative efficacy, including the improving long-term prognosis and the life quality of the patients, however the traditional chemotherapeuatic drugs showed the some limitatious in the aspects of enhancing the complete remission rate of newly diagnosed AML patients, overcoming the relapse after remission,as well as the primary and secondary drug-resstance to chemotherapeutics. In order to improve the long-term prognisis of patients, the immuno therapy will the best choice for these patients. This review sammarizes the main current advance of immunotherapy of AML at home and abroad, such as antibody-drug conjugate(ADC), bispecific T cell engager (BiTE), chimeric type of antigen receptor T cell (CAR-T) therapy, checkpoint inhibitors; dendritic cell vaccination and peptide vaccines; natural killer cell (NK) therapy and so on. Read More

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http://dx.doi.org/10.19746/j.cnki.issn1009-2137.2019.02.053DOI Listing
April 2019
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[Establishment of STO Cell Lines Expressing Green Fluorescent Protein and Mouse Leukemia Inhibitory Factor].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):606-612

Department of Pathophysiology, Bengbu Medical College, Bengbu 233030, Anhui Province, China E-mail:

Objective: To establish the STO cell lines expressing green fluorescent protein (GFP) and mouse leukemia inhibitory factor (LIF) , and try to culture the mouse embryonic stem cells (mESCs) by using the established STO-GFP-mLIF cells as the feeder layer.

Methods: The lentiviral particles containing GFP and mLIF and puromycin-resistance gene were constructed and transduced into STO cell lines. The cell lines stably expressing GFP and mLIF genes were screened out. Read More

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http://dx.doi.org/10.19746/j.cnki.issn1009-2137.2019.02.048DOI Listing

[Efficacy and Safety of Decitabine Combined with CAG (Cytarabine, Aclarubicin, G-CSF) for Patients with Intermediate or High Risk Myelodysplastic Syndrome and Acute Myeloid Leukemia: a Meta-Analysis].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):494-503

Fujian Institute of Hematology,Fujian Provincial Key Laboratory on Hematology,Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.

Objective: To systematically evaluate the efficacy and safety of DCAG regimen for treating the intermediate or high risk MDS and AML.

Methods: PubMed, EMbase, The Cochrane Library, WanFang Data and CNKI databases were searched to collect randomized controlled trials (RCTs) of decitabine combined with CAG regimen for intermediate or high risk MDS and AML from inception to March, 2018. The quality of each RCT was evaluated by the Cochrane collaboration´s tool for assessing the risk of bias. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.030DOI Listing
April 2019
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[Change of ROCK1 Gene Expression Level in Patients with Acute Lymphoblastic Leukemia and Its Clinical Significance].

Authors:
Wen-Hua He

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):415-420

Department of Hematology, Suining Central Hospital of Sichuan, Suining 629000, Sichuan Province,

Objective: To investigate the expression change of ROCK1 gene in patients with acute lymphoblastic leukemia (ALL) and its prognostic significance.

Methods: Sixty patients with ALL were selected in our hospital from April 2017 to April 2018, and 60 healthy persons subjected to physical examination were selected as control. The venous blood was taken from the subjects, and then the mononuclear cells were separated. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.017DOI Listing

[Effects of a Traditinal Chinese Medicine Compound Regimen on Differentiation and Proliferation of Acute Myeloid Leukemia Cell Lines].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):403-408

Laboratory for Stem Cell and Regenerative Medicine,Affiliated Hospital of Weifang Medical College, Weifang 261042, Shandong Province,

Objective: To study the effect of traditional chinese medicine (TCM) compound on myeloid leukemia cells and to explore its anti-leukemic mechanism.

Methods: Myeloid leukemia cell lines were cultured in vitro and treated with TCM compound. The proliferation of the leukemia cells was measured by CCK8 method. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.015DOI Listing

[Overexpression of miR-30a Promotes Apoptosis of Leukemia K562 Cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):396-402

Department of Immunology, College of Basic Medical Science ,Chongqing Medical University, Chongqing 400016, China,E-mail:

Objective: To investigate the pro-apoptotic effect and mechanism of miR-30a overexpression on chronic myeloid leukemia K562 cells.

Methods: The k562 cells were transfected with the recombinant plasmid pEGFP-pre-miR-30a, the real-time quantitative PCR was used to detect the level of miR-30a and BCR/ABL, and then the cell apoptosis was assessed by flow cytometry with AnnexinV-FITC/PI double staining. Western blot was used to detect the expression of BCR/ABL protein,apoptosis-related protein BCL-2 and BAX, PTEN, AKT and p-AKT. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.014DOI Listing
April 2019
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[Efficacy, Prognosis and Safety of Decitabine Combined with Low-Dose Cytarabine in the Treatment of Elderly Patients with Relapsed/Refractory Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):390-395

Department of Hematology, Yinzhou Hospital Affiliated to Ningbo University, Ningbo 315105, Zhejiang Province, China.

Objective: To investigate the efficacy, prognosis and safety of decitabine combined with low-dose CAG regimen in the treatment of elderly patients with acute myeloid leukemia (AML).

Methods: The clinical data of 40 elderly patients with relapsed/refractory AML (69-85 years old) admitted to our hospital from January 2014 to August 2016 were analyzed retrospectively. 40 patients were divided into combination therapy group and CAG group according to different treatment methods. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.013DOI Listing

[Effect of Mangiferin on Proliferation of FLT3-ITD Mutation Positive Acute Myeloid Leukemia Cell MV4-11 and Its Mechanism].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):385-389

Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.

Objective: To investigate the effects of mangiferin on proliferation, apoptosis and cycle of FLT3-ITD mutation-positive acute myeloid leukemia cells and its mechanism.

Methods: The effects of different concentration of mangiferin on proliferation of MV4-11 cells were detected by CCK8 method. Apoptosis, cell cycle and FLT3 transmembrane protein expression were detected by flow cytometry. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.012DOI Listing

[Expression and Clinical Significance of PD-L1 and MicroRNA-138-5p in Patients with Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):373-378

Center of Clinical Laboratorial Medicine,The First Affiliated Hospital of Jinan University,Guangzhou 510630, Guangdong Province, China,E-mail:

Objective: To investigate the expression and clinical significance of PD-L1 and microRNA-138-5p in the peripheral blood mononuclear cells of patients with acute myeloid leukemia.

Methods: The SYBR GreenⅠreal-time PCR was used to detect the expression levels of PD-L1 mRNA and miR-138 in 20 cases of primary AML, 9 cases of relapsed/refractory AML and 8 cases of complete remission. The samples of peripheral blood of 20 healthy peoples were used as controls. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.010DOI Listing
April 2019
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[NPM1 High Mutant Allele Burden is an Adverse Prognostic Factor for AML Patients with Mutated NPM1].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):365-372

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Objective: To investigate the clinical features, accompanying gene mutation characteristics and prognostic factors of adult patients with acute myeloid leukemia with mutated NPM1 (NPM1AML).

Methods: Seventy-three patients with newly diagnosed adult NPM1AML were selected. The mutations of 22 genes were detected by second generation sequencing and 43 fusion genes of AML were detected by real-time fluorescent quantitative PCR. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.009DOI Listing
April 2019
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[Clinical Efficacy of Modified BU/CY as Conditioning Regimen Combined with Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation in Young Acute Myeloid Leukemia Patients with Low or Intermediate Risk].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):360-364

Second Clinical College, Shanxi Metical University; Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,E-mail:

Objective: To investigate the safety and efficacy of autologous peripheral blood hematopoietic stem cell transplantation (auto-PBHSCT) using modified BU/CY conditioning regimen for young AML patients of low and middle risk in the first complete remission (CR1).

Methods: Ten young AML patients of low and middle risk who did not want to accept allogeneic hematopoietic stem cell transplantation(allo-HSCT)and underwent auto-PBHSCT in CR1 during May 2013 to December 2016 were retrospectively analyzed. From 3 months after auto-PBHSCT, the maintenance therapy with interleukin-2 (IL-2) or IL-2 combined with histamine dihydrochloride was performed for these patients in the next 18 months. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.008DOI Listing
April 2019
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[Clinical Characteristics of Patients with Ph Mixed Phenotype Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):354-359

Blood Diseases Hospital, Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300020

Objective: To investigate the clinical biological characteristics and prognosis of the patients with mixed phenotype acute leukemia with t(9;22)(q34;q11.2) and/or BCRABL1 (Ph MPAL).

Methods: The morphological, immunological, cytogenetic, and molecular features of 33 in patients with Ph MPAL were retrospectively analyzed in our center from June 2002 to June 2016 according to the scoring proposal of European Group for the Classification of Acute Leukemia(EGIL )1998 and WHO 2008 criteria. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.007DOI Listing

[Mutation Spectrum of FANCJ Gene in Adult Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):348-353

Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China,E-mail:

Objective: To detect and analyze the mutation status of FANCJ gene in adult AML patients, so as to provide the basis for studying the mechanism of FANCJ driven AML and guiding the preventim and treatment of deseese.

Methods: The cDNAs were extracted and transeripted from bone marrow cells and normal skin cells in 222 newly diagnosed AML patients. The primers were designed for FANCJ gene coding region, the mutations of FANCJ gene coding region in AML patients as well as the mutations of FANCJ gene in mucous membrane epethelia in patients were detected by PCR and sanger seguencing; the evolutionary conservation of FANCJ mutation in different organisms was analyzed by NCBI Blast online bioinformaties software. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.006DOI Listing

[E-cadherin Expression in Children with Acute Leukemia and Its Clinical Significance].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):339-347

Department of Hematology & Oncology, Childhren's Hospital Affiliated to Chongqing Medical University; Key Laboratory of Child Development and Disorders of Ministry of Education; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China,E-mail:

Objective: To investigate the correlation of E-cadherin expression level with the clinical characterastics in children with acute leukemia (AL), and to explore the possible regulatory mechanism.

Methods: Real-time quantitative RT-PCR was applied to detect the expression level of E-cadherin in bone marrow samples from 135 child patients diagnosed as AL, and its relevance with clinical indicators was statistically analyzed. The expression levels of E-cadherin, β-catenin, and Akt/p-Akt were detected by using Western blot. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.005DOI Listing

[Analysis of Unfavorable Prognosis Gene Markers in Patients with Acute Myeloid Leukemia by Multiomics].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):331-338

School of Management, Shanxi Medical University, Taiyuan 030001, Shanxi Province,China,E-mail:

Objective: To analyze the molecular markers associated with occurrence, development and poor prognosis of acute myeloid leukemia (AML) by using the data of GEO and TCGA database, as well as multiomics analysis.

Methods: The transcriptome data meeting requirements were down-loaded from GEO database, the differentially expressed genes were screened by using the R language limma package, and the GO function enrichment analysis and KEGG pathway analysis were performed for differentially expressed genes, at the same time, the protein interaction network was contracted by using STRING database and cytoscape software to screen out the hub gene, then the prognosis analysis was carried out for hub gene by combination with the clinical information affected in TCGA database.

Results: 620 differentially expressed genes were screened out, among which 162 differentially expressed genes were up-regulated, and 458 differentially expressed genes were down-regulated. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.004DOI Listing

[Detection and Analysis of T Lymphocyte Subsets and B Lymphocytes in Patients with Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):327-330

Department of Hematology, The First Hospital of Lanzhou University, Laznhou 730000, Gansu Province, China.

Objective: To investigate the changes of T lymphocyte subsets, B lymphocyte and NK cells in peripheral blood of patients with acute leukemia at different periods and their significance.

Methods: The peripheral T lymphocyte subsets and B lymphocyte of 95 patients with acute leukemia [(43 cases of acute lymphoblastic leukemia (ALL), 52 cases of acute myeloid leukemia (AML)] and 50 normal people were detected by flow cytometry respectively.

Results: The positive rate of CD3, CD3CD4, CD3CD8, NK cells and CD4/CD8 in the patients with newly diagnosed acute leukemia were significantly lower than those in normal controls (P<0. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.003DOI Listing

[Role of Vascular Niche of Bone Marrow in the Development of MLL-AF9 Induced Acute Myclaid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):318-326

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.E-mail:

Objective: To investigate the role of bone marrow vascular niche in the development of MLL-AF9 acute myeloid leukemia (AML).

Methods: Transplantation experiments were performed to establish non-radiated MLL-AF9 AML model; the half-bone immunofluorescence staining and tile-scan imaging of two-photon confocal microscopy were used to obtain the data of 3 main bone marrow niche cells; flow cytometry analysis was performed to characterize leukemia cells in different anatomical sites.

Results: In the early stage of MLL-AF9 AML, the proportion of leukemia cells in the metaphysis of the femur was significantly higher than that in the diaphysis. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.002DOI Listing
April 2019
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[Bioinformatics Analysis and Verification of Aging-Related Genes of Bone Marrow Mesenchymal Stem Cells in Patients with Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):311-317

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China,E-mail:

Objective: To screen and verify the differentially expressed genes related with aging of bone marrow mesenchymal stem cells (BM-MSCs) in acute myeloid leukemia (AML) patients by bioinformatics, so as to provide new molecular markers for the research and clinical treatment of AML.

Methods: The gene expression profiling chip related with BM-MSCs in AML patients in our hospital and the gene chip GSE84881 selected from NCBI database GEO were used for data analysis and exploration. The DAVID analysis software was used to perform gene ontology (GO) enrichment analysis and KEGG pathway enrichment analysis. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.001DOI Listing

The Influence of Proinflammatory Cytokines on Voriconazole Trough Concentration in Patients With Different Forms of Hematologic Disorders.

J Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Even though multiple factors are involved in the high fluctuation of voriconazole (VCZ) plasma concentration, little is known regarding the influence of proinflammatory cytokines on VCZ concentration. The aim of this study was to investigate the influence of proinflammatory cytokines, namely, interleukin (IL)-1β, IL-6, IL-18, interferon-γ, tumor necrosis factor-α, and transforming growth factor (TGF)-β1 on VCZ trough concentration (VCZ-C ) in Chinese patients with different forms of hematologic disorders. A total of 250 plasma samples from 113 patients were analyzed for VCZ-C and proinflammatory cytokines using a validated liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay methods, respectively. Read More

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http://dx.doi.org/10.1002/jcph.1422DOI Listing

Variant allele frequencies do not correlate well with myeloblast counts in a clinically validated gene sequencing panel for routine acute myeloid leukemia workup.

Leuk Lymphoma 2019 Apr 18:1-8. Epub 2019 Apr 18.

a Department of Pathology and Laboratory Medicine , Dartmouth-Hitchcock Medical Center One Medical Center Drive , Lebanon , NH , USA.

Next generation sequencing (NGS) has introduced new types of data, such as variant allele frequencies (VAFs), into the workup of acute myeloid leukemias (AML). There is interest in using NGS to prognosticate disease behavior and monitor residual disease, but the attribution of sequencing data entirely to the leukemic clone may be confounded by VAF contribution from background non-leukemic populations and undetected copy number aberrations. Sixty-eight patients with AML were evaluated by a clinically validated gene sequencing panel at our institution from 2015 to 2018. Read More

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http://dx.doi.org/10.1080/10428194.2019.1587757DOI Listing

FLT3 inhibitor quizartinib (AC220).

Leuk Lymphoma 2019 Apr 18:1-11. Epub 2019 Apr 18.

a Department of Leukemia , University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Acute myeloid leukemia (AML) is a heterogeneous disease and remains a therapeutic challenge. Cytogenetics is a well-established prognostic factor. Recent discovery of molecular mutations has gained momentum with some being potential therapeutic targets. Read More

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http://dx.doi.org/10.1080/10428194.2019.1602263DOI Listing

Assessment of Radiation Safety Knowledge Among Urology Residents in the United States.

J Endourol 2019 Apr 18. Epub 2019 Apr 18.

University of Kentucky, 4530, Urology, Lexington, Kentucky, United States ;

Introduction: Urologists are increasingly exposed to fluoroscopy, which can cause cellular damage. Appropriate knowledge and safety precautions concerning fluoroscopy are necessary and ideally should be taught in training. We sought to assess radiation safety knowledge among Urology residents in the United States. Read More

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http://dx.doi.org/10.1089/end.2019.0133DOI Listing

The role of mediastinoscopy in the diagnosis of thoracic disease: 107-case analysis.

Med Glas (Zenica) 2019 Aug 1;16(2). Epub 2019 Aug 1.

Department of Thoracic Surgery, School of Medicine, Canakkale Onsekiz Mart University, Turkey.

Aim To evaluate the efficacy, safety and feasibility of mediastinoscopy in 107 cases with mediastinal lesions that could not be diagnosed histopathologically with other methods. Methods A total of 107 cases (73 males, 34 females; mean age 57.4, range 30-88 years) with mediastinal lymphadenopathy, who underwent mediastinoscopy between 12 September 2012 and 29 November 2018 were examined retrospectively. Read More

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http://dx.doi.org/10.17392/1001-19DOI Listing

High expression of miR-338 is associated with poor prognosis in acute myeloid leukemia undergoing chemotherapy.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Blood Diseases Institute, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Acute myeloid leukemia (AML) is a heterogeneous disease with unfavorable outcomes. MicroRNAs (miRNAs) are important regulators and prognostic factors involved in AML. To determine the clinical role of miR-338 in AML, a total of 164 adults with de novo AML were collected. Read More

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http://dx.doi.org/10.1002/jcp.28676DOI Listing

The Bone Phenotype and Pain Response to Pamidronate in Tyrosine Kinase Inhibitor-Treated Chronic Myelogenous Leukemia.

J Endocr Soc 2019 May 11;3(5):857-864. Epub 2019 Mar 11.

Pediatric Bone Health Clinical Research Program, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.

Tyrosine kinase inhibitors (TKIs) have been linked to bone pain and linear growth attenuation in children with TKI-treated chronic myelogenous leukemia (CML). We describe the skeletal phenotype in an 11-year-old boy with chronic bone pain due to TKI-treated CML, including his response to intravenous (IV) pamidronate. This boy was diagnosed with Philadelphia chromosome-positive CML at 4 years of age. Read More

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http://dx.doi.org/10.1210/js.2018-00268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462212PMC

A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia.

Clin Case Rep 2019 Apr 20;7(4):695-698. Epub 2019 Feb 20.

2nd Department of Dermatology and Venereology, General Hospital "Papageorgiou", Medical School Aristotle University of Thessaloniki Thessaloniki Greece.

Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time. Read More

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http://dx.doi.org/10.1002/ccr3.2072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452460PMC

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.

ACS Med Chem Lett 2019 Apr 26;10(4):639-643. Epub 2019 Feb 26.

Instituto de Química Médica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.

Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound , featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466818PMC

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology. The reciprocal interplay between PSCs and pancreatic cancer cells (PCCs) not only enhances tumour progression and metastasis but also sustains their own activation, facilitating a vicious cycle to exacerbate tumorigenesis and drug resistance. Read More

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http://dx.doi.org/10.1038/s41586-019-1130-6DOI Listing

A novel NPM1-RARG-NPM1 chimeric fusion in acute myeloid leukaemia resembling acute promyelocytic leukaemia but resistant to all-trans retinoic acid and arsenic trioxide.

Br J Cancer 2019 Apr 18. Epub 2019 Apr 18.

Department of Hematology, The 2nd Affiliated Hospital of Harbin Medical University, 150001, Harbin, China.

The RARG gene is a member of the nuclear hormone receptor superfamily and shares high homology with RARA and RARB. RARA is involved in translocation with PML in acute promyelocytic leukaemia (APL). Little is known about RARB or RARG rearrangement. Read More

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http://www.nature.com/articles/s41416-019-0456-z
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http://dx.doi.org/10.1038/s41416-019-0456-zDOI Listing
April 2019
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Which patients with ischaemic priapism require further investigation for malignancy?

Int J Impot Res 2019 Apr 17. Epub 2019 Apr 17.

Andrology Department, University College, 47 Wimpole St, London, W1G 8PH, UK.

Ischaemic priapism (IP) is characterised by a persistent, painful penile erection lasting for >4 h. Many causes of IP have been identified including haematological dyscrasias (particularly, sickle cell disease), drugs and rarely malignancy. There are also a large proportion of men, in which no aetiology is identified. Read More

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http://dx.doi.org/10.1038/s41443-019-0141-zDOI Listing

Clinical Features, Pathological Features, and Treatment Outcomes of 22 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated with a Humanized CCR4 Antibody (Mogamulizumab) at a Single Institution during a 6-year Period (2012-2018).

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, Kurume University, Japan.

Objective To elucidate the clinical impact of humanized CCR4 antibody (mogamulizumab) on adult T-cell leukemia-lymphoma (ATL), we retrospectively analyzed the clinical and pathological features and treatment outcomes of aggressive ATL. Methods Twenty-two patients (median age: 65 years) with aggressive ATL (acute- [n=16] or lymphoma-type [n=6]) had their characteristics analyzed. All cases were treated with mogamulizumab at our institution from 2012 to 2018. Read More

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http://dx.doi.org/10.2169/internalmedicine.2513-18DOI Listing

Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Plasma cell leukemia (PCL) is a rare variant of multiple myeloma. The detection of plasma cells in the peripheral blood and monoclonal protein in the serum or urine is important for the diagnosis of PCL. However, it is sometimes difficult to diagnose PCL in patients with atypical plasma cell morphology and/or those without detectable monoclonal protein. Read More

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http://dx.doi.org/10.2169/internalmedicine.2472-18DOI Listing

The reduced folate carrier: an entry receptor for a novel feline leukemia virus variant.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan

Feline leukemia virus (FeLV) is horizontally transmitted among cats and causes a variety of hematopoietic disorders. Five subgroups of FeLV, A-D and T, each with distinct receptor usage, have been described. Recently, we identified a new FeLV Env (TG35-2) gene from a pseudotyped virus that does not belong to any known subgroup. Read More

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http://dx.doi.org/10.1128/JVI.00269-19DOI Listing

Early infection with cytomegalovirus and risk of childhood hematological malignancies.

Cancer Epidemiol Biomarkers Prev 2019 Apr 17. Epub 2019 Apr 17.

Institute of Environmental Medicine, Unit of Epidemiology, Karolinska Institute.

Background: Congenital cytomegalovirus (CMV) infection was recently identified as a risk factor for childhood acute lymphocytic leukemia by detecting the presence of CMV sequences in neonatal blood spots. In the current study, we asked whether clinically apparent CMV infection could be identified prior to hematological malignancy, using high quality Swedish population-based registries.

Methods: CMV infection was identified with appropriate ICD-9 or ICD-10 codes in the Patient and Medical Birth Registries, and childhood malignancies below the age of 15 were identified in the Cancer Registry, among 2,782,507 children born in Sweden 1987 to 2014. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-19-0044DOI Listing

Construction of the safe neutralizing assay system using pseudotyped Nipah virus and G protein-specific monoclonal antibody.

Biochem Biophys Res Commun 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Republic of Korea; Department of Bio-industrial Technologies, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

Nipah virus (NiV) is a recently emerged paramyxovirus that causes acute respiratory illness and fatal encephalitis in a broad spectrum of vertebrates, including humans. Due to its high pathogenicity and mortality rates, NiV requires handling in biosafety level-4 (BSL-4) containment facilities and no effective vaccines or therapeutic agents are currently available. Since current diagnostic tests for detecting serum neutralizing antibodies against NiV mainly employ live viruses, establishment of more safe and robust alternative diagnostic methods is an essential medical requirement. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.212DOI Listing

Xenotropic and polytropic retrovirus receptor 1 (XPR1) promotes progression of tongue squamous cell carcinoma (TSCC) via activation of NF-κB signaling.

J Exp Clin Cancer Res 2019 Apr 17;38(1):167. Epub 2019 Apr 17.

Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.

Background: Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular receptor for several murine leukemia viruses, plays a role in many pathophysiological processes. However, the role of XPR1 in human cancers has not yet been characterized.

Methods: Real-time PCR and western blotting assay were used to measure the expression of XPR1 in tongue squamous cell carcinoma (TSCC) tissues. Read More

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http://dx.doi.org/10.1186/s13046-019-1155-6DOI Listing

Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia.

Bosn J Basic Med Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia; Department of Hematology and Blood Transfusion, Faculty of Medical Laboratory Sciences, Alzaeim Alazhari University, Khartoum, Sudan.

The glutathione S-transferase (GST) genes encode enzymes that mediate the detoxification of xenobiotics by catalyzing the conjugation of glutathione (GSH) to xenobiotic substrates. The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) among Sudanese patients. Patients with CML (n = 115) were recruited to the study from the Radiation and Isotope Centre Khartoum (RICK)-Sudan. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4176DOI Listing

Therapy of Relapsed/Refractory Acute Lymphoblastic Leukemia Today and Tomorrow.

Klin Onkol 2019 ;32(2):90-96

Background: New diagnostics and treatments, including the use of new drugs, have advanced considerably the treatment of acute lymphoplastic leukemia (ALL) in the past few years. Monoclonal antibodies and immunoconjugates targeting antigens CD19 and CD22 show greater efficacy and more favourable toxicity profiles than standard salvage chemotherapeutic protocols. Two of these drugs - blinatumomab and inotuzumab ozogamicin - have already made their way into clinical practice. Read More

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http://dx.doi.org/10.14735/amko201990DOI Listing
January 2019

Retroperitoneal Hematoma after Bone Marrow Biopsy: The First Cut Should Not Be the Deepest.

Oncol Res Treat 2019 Apr 17;42(5):279-284. Epub 2019 Apr 17.

Department of Internal Medicine II, Asklepios Clinic Uckermark, Schwedt, Germany,

Bone marrow biopsies are standard hematology procedures. We report the case of a patient with acute myeloid leukemia who developed retroperitoneal hematoma after the procedure. The bleeding was stopped with endovascular embolization and coiling. Read More

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https://www.karger.com/Article/FullText/499743
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http://dx.doi.org/10.1159/000499743DOI Listing
April 2019
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Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Cell Rep 2019 Apr;27(3):690-698.e4

Division of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Scotland, UK. Electronic address:

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk. However, whether this is mediated by cell-autonomous AMPK activation within tumor progenitor cells has been unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193039
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http://dx.doi.org/10.1016/j.celrep.2019.03.067DOI Listing
April 2019
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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
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Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia.

J Clin Oncol 2019 Apr 17:JCO1801460. Epub 2019 Apr 17.

18 Ulm University, Ulm, Germany.

Purpose: A randomized, double-blind, phase III study of idelalisib (IDELA) plus rituximab versus placebo plus rituximab in patients with relapsed chronic lymphocytic leukemia (CLL) was terminated early because of superior efficacy of the IDELA-plus-rituximab (IDELA/R) arm. Patients in either arm could then enroll in an extension study to receive IDELA monotherapy. Here, we report the long-term efficacy and safety data for IDELA-treated patients across the primary and extension studies. Read More

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http://dx.doi.org/10.1200/JCO.18.01460DOI Listing

Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity.

JCO Clin Cancer Inform 2019 Apr;3:1-10

1 All authors: Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from pre-existence or by evolving new genotypes and traits. Intratumor heterogeneity serves as a reservoir for resistance, which often occurs as a result of the selection of minor cellular subclones. Read More

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http://dx.doi.org/10.1200/CCI.18.00074DOI Listing

A Case of Childhood Blastic Phase Chronic Myeloid Leukemia With Minor BCR-ABL.

J Pediatr Hematol Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pediatrics, National Center for Global Health and Medicine.

Chronic myeloid leukemia (CML) is commonly associated with major BCR-ABL transcript. We present a child with blastic phase CML associated with minor BCR-ABL transcript without prior CML diagnosis. Diagnosis was achieved by fluorescence in situ hybridization of peripheral blood neutrophils, which identified 90% as BCR-ABL positive. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001488DOI Listing
April 2019
1 Read