313,014 results match your criteria Leukemia & Lymphoma[Journal]


Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.

Pediatr Transplant 2019 Feb 20:e13378. Epub 2019 Feb 20.

Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

JMML is an aggressive hematopoietic malignancy of early childhood, and allogeneic HSCT is the only curative treatment for this disease. Umbilical cord blood is one of donor sources for HSCT in JMML patients who do not have an HLA-compatible relative, but engraftment failure remains a major problem. Here, we report two cases of JMML who were successfully rescued by HSCT from an HLA-mismatched parent after development of primary engraftment failure following unrelated CBT. Read More

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http://dx.doi.org/10.1111/petr.13378DOI Listing
February 2019

Central venous line-related thromboembolism is common in children with non-high risk acute lymphoblastic leukaemia.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Department of Paediatric Haematology and Oncology, Oslo University Hospital, Norway.

Children with acute lymphoblastic leukaemia face increased risks of thromboembolism, and major risk factors for this serious treatment-related toxicity are central venous lines, asparaginase and steroids. Central venous lines have become standard care in paediatric oncology, facilitating therapy and improving patients' quality of life. However, up to half of the children with acute lymphoblastic leukaemia will develop asymptomatic central venous line-related thromboembolism. Read More

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http://dx.doi.org/10.1111/apa.14757DOI Listing
February 2019

Bayesian personalized treatment selection strategies that integrate predictive with prognostic determinants.

Biom J 2019 Feb 20. Epub 2019 Feb 20.

Quantitative Health Sciences and The Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

The evolution of "informatics" technologies has the potential to generate massive databases, but the extent to which personalized medicine may be effectuated depends on the extent to which these rich databases may be utilized to advance understanding of the disease molecular profiles and ultimately integrated for treatment selection, necessitating robust methodology for dimension reduction. Yet, statistical methods proposed to address challenges arising with the high-dimensionality of omics-type data predominately rely on linear models and emphasize associations deriving from prognostic biomarkers. Existing methods are often limited for discovering predictive biomarkers that interact with treatment and fail to elucidate the predictive power of their resultant selection rules. Read More

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http://dx.doi.org/10.1002/bimj.201700323DOI Listing
February 2019

Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.

PLoS One 2019 20;14(2):e0211228. Epub 2019 Feb 20.

Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHLN), CAML, Centro Cardiovascular da Universidade de Lisboa-CCUL, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.

Introduction: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction.

Methods: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211228PLOS
February 2019
3.234 Impact Factor

Viral infection detection using metagenomics technology in six poultry farms of eastern China.

PLoS One 2019 20;14(2):e0211553. Epub 2019 Feb 20.

China Animal Health and Epidemiology Center, Qingdao, Shandong, China.

With rapidly increasing animal pathogen surveillance requirements, new technologies are needed for a comprehensive understanding of the roles of pathogens in the occurrence and development of animal diseases. We applied metagenomic technology to avian virus surveillance to study the main viruses infecting six poultry farms in two provinces in eastern China. Cloacal/throat double swabs were collected from 60 birds at each farm according to a random sampling method. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211553PLOS
February 2019

Tyrosine Kinase Inhibitor Associated Fibrothorax.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

The University of Texas Health Science Center at Houston, Internal Medicine-Division of Critical Care Medicine, Houston, Texas, United States.

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http://dx.doi.org/10.1164/rccm.201806-1155IMDOI Listing
February 2019

Pre-analytical parameters associated with unsuccessful karyotyping in myeloid neoplasm: a study of 421 samples.

Braz J Med Biol Res 2019 Feb 14;52(2):e8194. Epub 2019 Feb 14.

Hospital Israelita Albert Einstein, São Paulo, SP, Brasil.

Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75). Read More

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http://dx.doi.org/10.1590/1414-431X20188194DOI Listing
February 2019

Multimedia Appendix Correction: mHealth Supportive Care Intervention for Parents of Children With Acute Lymphoblastic Leukemia: Quasi-Experimental Pre- and Postdesign Study.

JMIR Mhealth Uhealth 2019 Feb 20;7(2):e13159. Epub 2019 Feb 20.

School of Nursing, Fudan University, Shanghai, China.

[This corrects the article DOI: 10.2196/mhealth.9981. Read More

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http://mhealth.jmir.org/2019/2/e13159/
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http://dx.doi.org/10.2196/13159DOI Listing
February 2019
2 Reads

BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells.

Biomed Pharmacother 2019 Feb 19;112:108603. Epub 2019 Feb 19.

The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China. Electronic address:

C-21 steroids displayed the activities of immunosuppressive, anti-inflammatory and anti-virus effects by the reports. However, its antitumor effects and molecular mechanism remain unclear. We previously isolated and identified a C-21 steroidal glycoside (BW18) from the root of Cynanchum atratum Bunge. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108603DOI Listing
February 2019

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

Eur J Med Chem 2019 Jan 26;166:514-530. Epub 2019 Jan 26.

Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35128, Padova, Italy. Electronic address:

A small library of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones has been synthesized and screened according to protocols available at the National Cancer Institute (NCI). Some derivatives were potent antiproliferative agents, showing GI values in the nanomolar range. Remarkably, when most active compounds against leukemia cells were tested in human peripheral blood lymphocytes from healthy donors, were 100-200 times less cytotoxic. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.049DOI Listing
January 2019
3.447 Impact Factor

Pak1 gene functioned differentially in different BCR-ABL subtypes in leukemiagenesis and treatment response through STAT5 pathway.

Leuk Res 2019 Jan 24;79:6-16. Epub 2019 Jan 24.

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, People's Republic of China. Electronic address:

The BCR-ABL fusion gene (BCR-ABL) has different subtypes such as p210 and p190 with p190 appear to lead to a worse prognosis. To explore the mechanism of difference in pathogenesis and prognosis in different BCR-ABL subtype-related leukemia, expression profile microarray analysis was conducted between p190 and p210 patients and verified by RT-PCR. The p21-activated kinase (PAK1) gene was chosen and regulation of the PAK1-STAT5 biological axis and its influence on proliferation and apoptosis in leukemia cells were also analyzed. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.01.012DOI Listing
January 2019

ORP4L Extracts and Presents PIP from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Cell Rep 2019 Feb;26(8):2166-2177.e9

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China. Electronic address:

Leukemia stem cells (LSCs) are a rare subpopulation of abnormal hematopoietic stem cells (HSCs) that propagates leukemia and are responsible for the high frequency of relapse in therapies. Detailed insights into LSCs' survival will facilitate the identification of targets for therapeutic approaches. Here, we develop an inhibitor, LYZ-81, which targets ORP4L with high affinity and specificity and selectively eradicates LCSs in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.082DOI Listing
February 2019

CAR T cells for Acute Lymphoblastic Leukemia.

Authors:
Noelle V Frey

Am J Hematol 2019 Feb 19. Epub 2019 Feb 19.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.

Chimeric Antigen Receptor (CAR) modified T cells targeted to CD19 have resulted in unprecedented remission rates for adult and pediatric patients with relapsed and refractory B cell acute lymphoblastic leukemia (ALL). With regulatory approval for tisagenlecleucel and many other agents under active investigation, the use of CAR T cells for ALL continues to expand. While some remissions from anti-CD19 CAR T cells are durable without a consolidative allogeneic stem cell transplantation, CD19 positive and negative relapses remain a significant concern fueling investigations into the biology of CAR T cell persistence and the development of CARTs that target more than one antigen. Read More

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http://dx.doi.org/10.1002/ajh.25442DOI Listing
February 2019

Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.

Br J Haematol 2019 Feb 19. Epub 2019 Feb 19.

Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19. Read More

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http://dx.doi.org/10.1111/bjh.15799DOI Listing
February 2019

Chronic myelomonocytic leukaemia followed by blastic plasmacytoid dendritic cell neoplasm.

Br J Haematol 2019 Feb 19. Epub 2019 Feb 19.

Laboratoire d'Hématologie Universitaire de Bordeaux, Pessac, France.

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http://dx.doi.org/10.1111/bjh.15794DOI Listing
February 2019

Untargeted adductomics of Cys34 modifications to human serum albumin in newborn dried blood spots.

Anal Bioanal Chem 2019 Feb 19. Epub 2019 Feb 19.

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, 94720, USA.

Metabolism of chemicals from the diet, exposures to xenobiotics, the microbiome, and lifestyle factors (e.g., smoking, alcohol intake) produce electrophiles that react with nucleophilic sites in circulating proteins, notably Cys34 of human serum albumin (HSA). Read More

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http://dx.doi.org/10.1007/s00216-019-01675-8DOI Listing
February 2019

Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia.

Oncotarget 2019 Jan 25;10(8):869-882. Epub 2019 Jan 25.

Pediatric Hematology/Oncology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

Nucleophosmin(NPM1)-mutated protein, a leukemia-specific antigen, represents an ideal target for AML immunotherapy. We investigated the dynamics of NPM1-mutated-specific T cells on PB and BM samples, collected from 31 adult -mutated AML patients throughout the disease course, and stimulated with mixtures of 18 short and long peptides (9-18mers), deriving from the complete C-terminal of the NPM1-mutated protein. Two 9-mer peptides, namely LAVEEVSLR and AVEEVSLRK (13. Read More

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http://dx.doi.org/10.18632/oncotarget.26617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368236PMC
January 2019

3D culture enhances chemoresistance of ALL Jurkat cell line by increasing DDR1 expression.

Exp Ther Med 2019 Mar 4;17(3):1593-1600. Epub 2019 Jan 4.

Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, P.R. China.

Three dimensional (3D) culture has gradually become a research hotspot in the field of drug screening, stem cell research, and tissue engineering due to its more physiological-like morphology and function. In this study, we compared the differences of cell proliferation, population, protein expression and chemoresistance profiles between two dimensional (2D) and 3D culture of acute lymphoblastic leukemia (ALL) Jurkat cell line. Polycaprolactone (PCL) is used for 3D culture owing to its biochemical properties and compatibility. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7153
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http://dx.doi.org/10.3892/etm.2019.7153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364197PMC
March 2019
1 Read

Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009.

Contemp Oncol (Pozn) 2018 31;22(4):266-269. Epub 2018 Dec 31.

Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland.

Sinusoidal obstruction syndrome (SOS), also termed veno-occlusive disease (VOD) of the liver, is a well-known complication of haematopoietic stem cell transplantation (HSCT) both in children and adults. In the medical literature there are occasional reports of SOS in patients receiving conventional chemotherapy. In children with solid tumours this entity occurs during treatment of nephroblastoma, rhabdomyosarcoma, and medulloblastoma. Read More

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http://dx.doi.org/10.5114/wo.2018.82646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377418PMC
December 2018

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells.

J Biol Chem 2019 Feb 19. Epub 2019 Feb 19.

Sichuan University, China.

Growth arrest and DNA damage-inducible gene 34 (GADD34) plays a critical role in responses to DNA damage and endoplasmic reticulum stress. GADD34 has opposing effects on different stimuli-induced cell apoptosis events, but the reason for this is unclear. Here, using immunoblotting analyses and various molecular genetic approaches in HepG2 and SMMC-7721 cells, we report that GADD34 protect hepatocellular carcinoma (HCC) cells from TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by stabilizing a BCL-2 family member, myeloid cell leukemia 1 (MCL-1). Read More

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http://dx.doi.org/10.1074/jbc.RA118.006029DOI Listing
February 2019

T-cell activity against AML improved by dual-targeted T cells stimulated through T-cell and IL7 receptors.

Cancer Immunol Res 2019 Feb 19. Epub 2019 Feb 19.

Pediatrics, University of Michigan-Ann Arbor

The development of engineered T cells to treat acute myeloid leukemia (AML) is challenging due to difficulty in target selection and the need for robust T-cell expansion and persistence. We designed a T cell stimulated to kill AML cells based on recognition of the AML-associated surface marker CLEC12A, via secretion of a CLEC12AxCD3 bispecific "engager" molecule (CLEC12A-ENG). CLEC12A-ENG T cells are specifically activated by CLEC12A, are not toxic to hematopoietic progenitor cells, and exhibit antigen-dependent AML killing. Read More

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0748DOI Listing
February 2019

Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence.

MBio 2019 Feb 19;10(1). Epub 2019 Feb 19.

Institute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

B cell follicles of the spleen and lymph nodes are immune privileged sites and serve as sanctuaries for infected CD4 cells in HIV infection. It is assumed that CD8 T cell responses promote the establishment of the reservoir, as B cell follicles do not permit CD8 T cell entry. Here we analyzed the infected cell population in the Friend retrovirus (FV) infection and investigated whether FV can similarly infect follicular cells. Read More

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http://dx.doi.org/10.1128/mBio.00004-19DOI Listing
February 2019

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.

Blood Adv 2019 Feb;3(4):552-563

The Leucegene Project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada.

Patients diagnosed with acute myeloid leukemia with complex karyotype (CK AML) have an adverse prognosis using current therapies, especially when accompanied by alterations. We hereby report the RNA-sequencing analysis of the 68 CK AML samples included in the Leucegene 415 patient cohort. We confirm the frequent occurrence of alterations in this subgroup and further characterize the allele expression profile and transcript alterations of this gene. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018028480DOI Listing
February 2019

Highly efficient Polyaniline-MoS hybrid nanostructures based biosensor for cancer biomarker detection.

Anal Chim Acta 2019 May 21;1055:26-35. Epub 2018 Dec 21.

CSIR-National Physical Laboratory, New Delhi, 110012, India. Electronic address:

In this work, polyaniline nanospindles have been synthesized using iron oxide as sacrificial template. These nanospindles were utilized for the fabrication of PANI-MoS nanoflower architectures via hydrothermal route. The electrostatic interaction between PANI and MoS improves the conductivity and provides more direct paths for charge transportation. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.033DOI Listing

Schizandrol A reverses multidrug resistance in resistant chronic myeloid leukemia cells K562/A02.

Authors:
Nurguli Arken

Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):78-83. Epub 2019 Jan 31.

Overexpression of P-gp is the main cause of multidrug resistance (MDR) and chemotherapeutic failure in leukemia. In this study, the multidrug resistance reverse effect of Schizandrol A (SchA) was demonstrated with P-gp overexpressed drug-resistant K562/A02 cells. SchA had almost no cytotoxic activity, the EC50 value reversed to DOX was in the nanomole range of (707 ± 29nM) and had a high selectivity index (> 113) to normal cells. Read More

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January 2019

Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription.

Retrovirology 2019 Feb 19;16(1). Epub 2019 Feb 19.

College of Chemistry and Life Sciences, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, Zhejiang, China.

Background: Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy resistance. Thus, it is urgent to develop new treatment strategies. Read More

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http://dx.doi.org/10.1186/s12977-019-0467-0DOI Listing
February 2019

Downregulation of MicroRNA-125a in Placenta Accreta Spectrum Disorders Contributes Antiapoptosis of Implantation Site Intermediate Trophoblasts by Targeting MCL1.

Reprod Sci 2019 Feb 19:1933719119828040. Epub 2019 Feb 19.

1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.

The typical hallmark of placenta accreta spectrum (PAS) disorders is increased implantation site intermediate trophoblast (ISIT) cell numbers. However, the extent of trophoblast proliferation and apoptosis have not been found to differ from those of normal placentation. MicroRNA-125a (miR-125a) induces apoptosis in colon cancer cell by targeting myeloid cell leukemia-1 gene ( MCL1). Read More

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http://dx.doi.org/10.1177/1933719119828040DOI Listing
February 2019

BRAF in the cross-hairs.

Expert Rev Hematol 2019 Feb 20. Epub 2019 Feb 20.

a Leukemia Service , Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center , New York , NY , 10065 , USA.

Introduction: Hairy cell leukemia (HCL) is a rare, chronic B-cell lymphoproliferative disorder characterized by distinctive morphologic features and an indolent clinical course. The discovery of a recurrent activating mutation in BRAF (BRAF V600E) as a disease-defining genetic event in HCL has substantial diagnostic and therapeutic implications. Areas covered: Herein the authors review the role of BRAF V600E and RAF-MEK-ERK signaling in the pathogenesis of HCL, anecdotal clinical reports of BRAF inhibitor monotherapy in management of relapsed or refractory HCL, larger phase 2 trials investigating efficacy of BRAF inhibitor therapy for HCL, adverse effects commonly associated with BRAF inhibitor therapy, including cutaneous toxicity, and mechanisms of therapeutic resistance. Read More

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http://dx.doi.org/10.1080/17474086.2019.1583553DOI Listing
February 2019

Radioactive iodine-refractory differentiated thyroid cancer: unmet needs and future directions.

Expert Rev Endocrinol Metab 2012 Sep;7(5):541-554

f Massachusetts General Hospital, Boston, MA, USA.

Approximately 90% of thyroid cancers are differentiated (DTCs) and have papillary, follicular or Hürthle cell morphology. Although treatment with surgery and radioactive iodine (I-131; RAI), as appropriate, is associated with significant cure rates and survival benefits, clonal disease progression with development of refractoriness to RAI poses a major therapeutic challenge in about 15% of patients. Traditional chemotherapeutic agents are relatively ineffective and are associated with significant toxicities. Read More

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http://dx.doi.org/10.1586/eem.12.36DOI Listing
September 2012

New Insights into Long Non-Coding RNA in Cancer and Metastasis.

Authors:
Yutong Sun Li Ma

Cancers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Metastasis-associated lung adenocarcinoma transcript 1 () is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to regulate alternative pre-mRNA splicing and gene expression. However, knockout mice develop and grow normally, and do not show alterations in alternative splicing. Read More

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http://dx.doi.org/10.3390/cancers11020216DOI Listing
February 2019

The Enigmatic Protein Kinase C-eta.

Authors:
Alakananda Basu

Cancers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Microbiology, Immunology & Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. Read More

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http://dx.doi.org/10.3390/cancers11020214DOI Listing
February 2019

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis.

Cells 2019 Feb 13;8(2). Epub 2019 Feb 13.

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

The regulation of oxygen (O₂) levels is crucial in embryogenesis and adult life, as O₂ controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for tissue physiology as they are integral to adequate metabolism regulation and cell fate. Hence, the hypoxia response is of utmost importance for cell, organ and organism function and is dependent on the hypoxia-inducible factor (HIF) pathway. Read More

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http://dx.doi.org/10.3390/cells8020155DOI Listing
February 2019

The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-cell Leukaemia.

Biomedicines 2019 Feb 16;7(1). Epub 2019 Feb 16.

The Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.

We have previously shown that antibody-dependent cellular cytotoxicity (ADCC) cooperates with immunotoxin (IT)-mediated killing of human leukaemia cells in an severe combined immunodeficient (SCID) mouse model of human T-cell acute lymphoblastic leukaemia (SCID-HSB-2 mice), but not in an equivalent non-obese diabetic (NOD)/SCID mouse model. In these earlier studies, we reasoned that diminished ADCC due to the functional deficit in natural killer (NK) cell activity in NOD/SCID mice resulted in a failure of effective perforin/granzyme-mediated cytotoxicity necessary for the delivery of the augmentative effect. Poly-inosinic-cytidylic acid [poly (I:C)] is a synthetic dsRNA toll-like receptor 3 (TLR3) agonist that possesses a number of biological properties that includes the in vivo activation of NK cells. Read More

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http://dx.doi.org/10.3390/biomedicines7010013DOI Listing
February 2019

Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

College of Health and Medicine, School of Health Sciences, University of Tasmania, TAS 7005, Australia.

Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic processes that lead to abnormally high levels of blood glucose. Preceding the development of T2DM is insulin resistance (IR), a disorder associated with suppressed or delayed responses to insulin. The effects of this response are predominately mediated through aberrant cell signalling processes and compromised glucose uptake into peripheral tissue including adipose, liver and skeletal muscle. Read More

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http://dx.doi.org/10.3390/nu11020408DOI Listing
February 2019
1 Read

Defective Sphingolipids Metabolism and Tumor Associated Macrophages as the Possible Links Between Gaucher Disease and Blood Cancer Development.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.

There is a rising number of evidence indicating the increased risk of cancer development in association with congenital metabolic errors. Although these diseases represent disorders of individual genes, they lead to the disruption of metabolic pathways resulting in metabolite accumulation or their deficiency. Gaucher disease (GD) is an autosomal recessive sphingolipidosis. Read More

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http://dx.doi.org/10.3390/ijms20040843DOI Listing
February 2019

Chronic myeloid leukemia: Two mysteries.

Leuk Res 2019 Feb 12;79:3-5. Epub 2019 Feb 12.

Haematology Research Centre, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.leukres.2019.02.003DOI Listing
February 2019

Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1203-1213

Department of Hematology, Jining No. 1 People's Hospital, Jining City, Shandong Province, China.

Objective: Deregulated expression of miRNAs contributes to the development of acute myeloid leukemia (AML). miR-504-3p, one of these miRNAs, has been found have upregulated expression in various human malignancies. Our present study aimed to detect the expression of miR-504-3p and its biological effect in AML. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17013DOI Listing
February 2019

Correlation between IL-7 genomic protein methylation level and acute myeloid leukemia.

Authors:
Z-H Li Y Liu S-Y Gao

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1196-1202

Medicine Experimental Training Center, Weifang Medical University, Weifang, P. R. China.

Objective: To detect Interleukin-7 (IL-7) gene methylation status and transcription level in leukemia cells of peripheral blood of patients with Acute Myelocytic Leukemia (AML) and in the cell lines (HL-60, HL-60/ADM, SKM-1) of AML and myelodysplastic syndrome (MDS), and explore its relationship with the pathogenesis of AML.

Patients And Methods: A total of 55 AML patients (AML group) and 30 healthy adults (Healthy group) from June 2015 to June 2018 were enrolled in this study. The genomic DNA of leukemia cells in peripheral blood was extracted. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17012DOI Listing
February 2019

Attenuating the abnormally high expression of AEBP1 suppresses the pathogenesis of childhood acute lymphoblastic leukemia via p53-dependent signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1184-1195

Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: This study aimed to explore the candidate genes and their potential mechanism in childhood acute lymphoblastic leukemia (cALL).

Materials And Methods: Differentially expressed genes (DEGs) were screened from GSE67684 (treatment), GSE28460 (relapse), and GSE60926 (relapse). The expression of AEBP1 at different stages of cALL was analyzed followed by functional enrichment analysis of its co-expressed genes. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17011DOI Listing
February 2019

Lymphoma and Leukemia Cell Vulnerabilities and Resistance Identified by Compound Library Screens.

Methods Mol Biol 2019 ;1956:351-362

Department of Haematology, Center for Oncology and Haematology, University Hospital and University of Zurich, Zurich, Switzerland.

Response to anticancer agents is often restricted to subsets of patients. The recognition of factors underlying this heterogeneity and the identification of biomarkers associated with response to drugs would greatly improve the efficacy of drug treatment. Platforms that can comprehensively map drug response in high-throughput ex vivo provide a unique tool to identify associated biomarkers and provide hypotheses for mechanisms underlying variable response. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_17DOI Listing
January 2019

MRD Detection in B-Cell Non-Hodgkin Lymphomas Using Ig Gene Rearrangements and Chromosomal Translocations as Targets for Real-Time Quantitative PCR.

Methods Mol Biol 2019 ;1956:199-228

Second Medical Department, University Hospital Schleswig-Holstein, Kiel, Germany.

Minimal residual disease (MRD) diagnostics is of high clinical relevance in patients with indolent B-cell non-Hodgkin lymphomas (B-NHL) and serves as a surrogate parameter to evaluate treatment effectiveness and long-term prognosis. MRD diagnostics performed by real-time quantitative PCR (RQ-PCR) is still the gold standard and currently the most sensitive and the most broadly applied method in follicular lymphoma (FL) and mantle cell lymphoma (MCL). Alternatively, droplet digital PCR (ddPCR) can be used for MRD monitoring in multiple myeloma, mantle cell lymphoma, and follicular lymphoma with comparable sensitivity, accuracy, and reproducibility. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_9DOI Listing
January 2019

Flow Cytometric MRD Detection in Selected Mature B-Cell Malignancies.

Methods Mol Biol 2019 ;1956:157-197

Division of Internal Medicine, Medical Clinic III-Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, Rostock, Germany.

The quantification of submicroscopic minimal residual disease (MRD) after therapy proved to have independent prognostic significance in many mature B-cell malignancies. With the advent of routine benchtop cytometers capable of simultaneously analyzing ≥4 colors and with improved standardization, flow cytometry has become the method of choice for MRD assessments in some lymphoma entities. Herein we describe general aspects of flow cytometric standardization. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_8DOI Listing
January 2019

Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas.

Methods Mol Biol 2019 ;1956:139-155

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.

Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG. This finding strongly supports selection by common epitopes or classes of structurally similar epitopes in the ontogeny of these tumors. BcR IG stereotypy was initially described in chronic lymphocytic leukemia (CLL), where the stereotyped fraction of the disease accounts for a remarkable one-third of patients. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_7DOI Listing
January 2019

Expression Cloning of Antibodies from Single Human B Cells.

Methods Mol Biol 2019 ;1956:105-125

Division of B-Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

The majority of lymphomas originate from B cells at the germinal center stage. Preferential selection of B-cell clones by a limited set of antigens has been suggested to drive lymphoma development. While recent studies in chronic lymphocytic leukemia have shown that self-reactive B-cell receptors (BCR) can generate cell-autonomous signaling and proliferation, our knowledge about the role of BCRs for the development or survival of other lymphomas remains limited. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_5DOI Listing
January 2019

Correction to: Venetoclax for Treating Chronic Lymphocytic Leukaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Pharmacoeconomics 2019 Feb 19. Epub 2019 Feb 19.

Warwick Evidence, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

Open Access This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License ( http://creativecommons.org/licenses/by-nc/4. Read More

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http://dx.doi.org/10.1007/s40273-019-00773-wDOI Listing
February 2019

Association of SLC28A3 Gene Expression and CYP2B6*6 Allele with the Response to Fludarabine Plus Cyclophosphamide in Chronic Lymphocytic Leukemia Patients.

Pathol Oncol Res 2019 Feb 18. Epub 2019 Feb 18.

Clinic for Hematology, Clinical Center of Serbia, Belgrade, Serbia.

Fludarabine plus cyclophosphamide (FC) chemotherapy is the basis of treatment protocols used in management of chronic lymphocytic leukemia (CLL). In some patients, response to therapy may be affected by aberrant function of genes involved in pharmacokinetics and pharmacodynamics of the drugs. The aim of this research was to assess the impact of pharmacogenetic variability, namely expression of SLC28A3 gene and the presence of CYP2B6*6 variant allele, on the FC treatment efficacy. Read More

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http://dx.doi.org/10.1007/s12253-019-00613-4DOI Listing
February 2019

Oncology nurse phone calls halve the risk of reduced dose intensity of immunochemotherapy: results of the randomized FORTIS study in chronic lymphocytic leukemia.

Ann Hematol 2019 Feb 18. Epub 2019 Feb 18.

University of Toulouse III Paul Sabatier, Toulouse, France.

Delivering of > 80% planned relative dose intensity (RDI) of fludarabine-cyclophosphamide-rituximab (FCR) is key to benefit from longer progression free survival (PFS) and survivals in CLL. In this randomized trial, we sought to investigate whether a telephone intervention strategy (called AMA) delivered by an oncology nurse could reduce the risk of RDI < 80% by alleviating adverse events and supporting patients' adherence. Sixty FCR patients were randomized 1:1 for AMA (stratified on Binet stage C). Read More

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http://dx.doi.org/10.1007/s00277-019-03631-zDOI Listing
February 2019

Doxorubicin treatments induce significant changes on the cardiac autonomic nervous system in childhood acute lymphoblastic leukemia long-term survivors.

Clin Res Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Laboratoire de Physiopathologie de l'EXercice (LPEX), Département de Kinésiologie, Université de Montréal, CEPSUM, 2100, boulevard Édouard Montpetit, H3C 3J7, Montreal, QC, Canada.

Aims: Acute lymphoblastic leukemia (ALL) is one of the leading malignancies in children worldwide. The cardiotoxicity of anti-cancer treatments leads to a dysfunction of the cardiac autonomic nervous system. Protection strategies, with dexrazoxane treatments, were used to counter these adverse effects. Read More

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http://dx.doi.org/10.1007/s00392-019-01427-9DOI Listing
February 2019

Effect of iron overload from multi walled carbon nanotubes on neutrophil-like differentiated HL-60 cells.

Sci Rep 2019 Feb 18;9(1):2224. Epub 2019 Feb 18.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa, 761-0395, Japan.

Multi walled carbon nanotubes (MWCNTs) are one of the most intensively explored nanomaterials because of their unique physical and chemical properties. Due to the widespread use of MWCNTs, it is important to investigate their effects on human health. The precise mechanism of MWCNT toxicity has not been fully elucidated. Read More

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http://dx.doi.org/10.1038/s41598-019-38598-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379482PMC
February 2019