11 results match your criteria Letters in Organic Chemistry[Journal]

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An Efficient Oxidation of Alcohols by Aqueous HO with 1,3-Dibromo-5,5-Dimethylhydantoin.

Lett Org Chem 2018 Oct;15(10):895-898

Department of Chemistry, Chung-Ang University, Seoul06974, Korea.

An efficient protocol is described for the oxidation of alcohols to the corresponding aldehydes or ketones with 1,3-dibromo-5,5-dimethylhydantoin in the presence of aqueous H2O2. Read More

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http://dx.doi.org/10.2174/1570178615666180613080548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174635PMC
October 2018

Direct Oxidation of Aldehydes to Methyl Esters with Urea Hydrogen Peroxide and -Toluenesulfonyl Chloride.

Lett Org Chem 2017 Dec;14(10):725-728

Department of Chemistry, Chung-Ang University, Seoul06974, Korea.

Combination of urea hydrogen peroxide and p-toluenesulfonyl chloride in methanol was proved to be facile and highly efficient for the oxidative methyl esterification of various aldehydes to the corresponding carboxylic methyl esters. Read More

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http://dx.doi.org/10.2174/1570178614666170918121035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791350PMC
December 2017
24 Reads

A Short Route to the Ester (±) HomoSarkomycin Johnson-Claisen Rearrangement.

Lett Org Chem 2017 Mar;14(3):181-185

Chemistry Department, College of Science and Arts at Ar Rass, Qassim University, Burayadah 51477, Saudi Arabia.

Background: α-Methylene cycloalkanones are considered of interest because of their biological activity. Herein, in this paper the synthesis of (±) HomoSarkomycine Esters was described and characterized.

Methods: Using Bylis-Hillman adducts, triethlorthoacetate and propanoic acid, (±) HomoSarkomycine Esters could be synthesized by smoothly Johnson-Claisen rearrangement. Read More

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http://dx.doi.org/10.2174/1570178614666161230123513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759048PMC
March 2017
12 Reads

FledFold: A Novel Software for RNA Secondary Structure Prediction.

Lett Org Chem 2017 Jun;14(9):714-716

Computer Science and Technology Department, Jilin University, Changchun, 130000, China.

Background: RNA secondary structure is essential to understand the mechanism of RNAs.

Method: In this paper, fledFold, a novel software for RNA secondary structure prediction, is introduced. It combines both thermodynamic and kinetic factors of RNA secondary structures and can predict RNA secondary structures from their primary sequences with local personal computers. Read More

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http://dx.doi.org/10.2174/1570178614666170419122621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652076PMC
June 2017
20 Reads

Visualization of Hyperconjugation and Subsequent Structural Distortions through 3D Printing of Crystal Structures.

Lett Org Chem 2016 ;13(4):272-276

Department of Chemistry, Center for Green Chemistry, University of Massachusetts Boston, MA 02125, USA.

Background: Structural distortions due to hyperconjugation in organic molecules, like norbornenes, are well captured through X-ray crystallographic data, but are sometimes difficult to visualize especially for those applying chemical knowledge and are not chemists.

Methods: Crystal structure from the Cambridge database were downloaded and converted to .stl format. Read More

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http://dx.doi.org/10.2174/1570178613666160204010454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484092PMC
January 2016
21 Reads

Synthesis of bis(indolyl)methanes Catalyzed by Triethylborane.

Lett Org Chem 2015 Jun;12(5):332-336

Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca- Tulancingo Km. 4.5, Mineral de La Reforma, Hidalgo, CP 42076, Mexico.

Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. Vibrindole and bis(indolyl)methanes derivatives and were synthesized using this methodology. Compound is an intermediary in the synthesis of the natural bisindoles arsindoline and streptindole . Read More

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http://dx.doi.org/10.2174/1570178612666150220225335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475781PMC
June 2015
14 Reads

A Novel Semisynthetic Anion Receptor: Synthesis and Ion Recognition of (1-H-pyrrol-2-yl)-4-oxo-perezone.

Lett Org Chem 2013 Nov;10:632-636

We describe the synthesis of the novel 2-(1,5-dimethyl-4-oxo-hexyl)-3-hydroxy-5-methyl-6-pyrrolyl-1,4-benzoquinone 2 from the natural product perezone 1. The anion-guest properties of the new compound were evaluated in the presence of fluoride, chloride, bromide and iodide tetrabutylammonium salts using 1H NMR titration techniques in deuterated dichloromethane or dimethylformamide. The title compound showed interesting colorimetric behavior in the presence of inorganic salts. Read More

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http://dx.doi.org/10.2174/15701786113109990035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796890PMC
November 2013
6 Reads

Synthesis and Evaluation of an -Aminated Naphthol AS-E as a Prodrug of CREB-mediated Gene Transcription Inhibition.

Lett Org Chem 2013 Jun;10(5):380-384

Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239, USA ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

An -aminated naphthol AS-E was designed as a prodrug to achieve reductive activation and improved aqueous solubility. During the synthesis of this designed compound, a novel transformation from aryl triflates and ethyl acetohydroximate to oxazoles was discovered. Although the initially designed -amino naphthol AS-E was not made successfully, the eventually synthesized --butylamino derivative was found to be biologically inactive, suggesting that reductive cleavage in this compound was not facile due to unfavorable steric and electronic effects. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184210PMC
June 2013
16 Reads

A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone.

Lett Org Chem 2012 Dec;9(10):762-766

Department of Pharmacy Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA ; Department of Thoracic Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55% yield of one structural isomer ( derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses. Read More

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http://dx.doi.org/10.2174/157017812803901890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039186PMC
December 2012
29 Reads

Pd/C-Catalyzed Cross-Coupling of Arenediazonium Salts with Potassium Aryltrifluoroborates.

Lett Org Chem 2010 Jan;7(1):1-6

Department of Chemistry, Physics, and Geology, Winthrop University, Sims Science Building, Rock Hill, SC 29733.

A convenient protocol for the synthesis of biaryls from arenediazonium salts and potassium aryltrifluoroborates in refluxing methanol catalyzed by Pd/C is described. The protocol is simple to execute and gives moderate to high yields of cross-coupling products in most cases. Read More

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http://dx.doi.org/10.2174/157017810790533968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114732PMC
January 2010
8 Reads

Preparation of Disubstituted Phenyl Propargyl Alcohols, their Use in Oxathiolene Oxide Synthesis, and Evaluation of the Oxathiolene Oxide Products as Anticarcinogenic Enzyme Inducers.

Lett Org Chem 2009 Apr;6(3):242-251

Department of Chemistry, Wake Forest University, P.O. Box 7486, Winston-Salem, NC 27109, USA.

A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dioxide. This methodology was used to prepare a number of oxathiolene oxides which have been screened as NQO1 (quinone oxidoreductase) inducers. Read More

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http://dx.doi.org/10.2174/157017809787893064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768303PMC
April 2009
14 Reads
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