3,759 results match your criteria Letters in Drug Design & Discovery[Journal]


Ocriplasmin Treatment Leads to Symptomatic Vitreomacular Adhesion/Vitreomacular Traction Resolution in the Real-World Setting: The Phase IV ORBIT Study.

Ophthalmol Retina 2019 Jan 25;3(1):32-41. Epub 2018 Jul 25.

California Retina Consultants, Santa Barbara, California; California Retina Research Foundation, Santa Barbara, California.

Purpose: To evaluate clinical outcomes and safety up to 12 months after ocriplasmin injection for the treatment of patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction (VMT) in a real-world setting.

Design: The Phase IV Ocriplasmin Research to Better Inform Treatment (ORBIT) trial (NCT02079883) was a Phase IV multicenter, prospective, observational study.

Participants: Patients aged ≥18 years with symptomatic VMA/VMT treated with ocriplasmin. Read More

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http://dx.doi.org/10.1016/j.oret.2018.07.011DOI Listing
January 2019
2 Reads

Promoting cannabis products to pharmaceutical drugs.

Eur J Pharm Sci 2019 Apr 7;132:118-120. Epub 2019 Mar 7.

Institute of Plant Science, Agriculture Research Organization, Volcani Center, Rishon LeZion 7528809, Israel.

Cannabis sativa is widely used for medical purposes. However, to date, aroma, popular strain name or the content of two phytocannabinoids-Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are mostly considered for therapeutic activity. This is despite the hundreds of compounds in this plant and their potential synergistic interactions in mixtures. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.027DOI Listing
April 2019
6 Reads

Chronic obstructive pulmonary disease (COPD) among opioid-dependent patients in agonist treatment. A diagnostic study.

Addiction 2019 Jan 24. Epub 2019 Jan 24.

Institute of Primary Care (IHAMZ), University and University Hospital of Zurich, Zurich, Switzerland.

Aims: To estimate the prevalence of chronic obstructive pulmonary disease (COPD) and related risk factors in people in opioid agonist treatment (OAT), to compare airflow limitation severity and age-specific COPD prevalence rates with those in the general population, and to assess the OAT patients' willingness to adopt life-style changes and to use therapeutic offers for COPD management.

Design: Cross-sectional study in a random sample of OAT patients.

Setting: Out-patient centres for substance addiction medicine in Zurich, Switzerland. Read More

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http://doi.wiley.com/10.1111/add.14559
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http://dx.doi.org/10.1111/add.14559DOI Listing
January 2019
15 Reads

Comparison of the efficacy and safety of drug therapies for macular edema secondary to central retinal vein occlusion.

BMJ Open 2018 Dec 28;8(12):e022700. Epub 2018 Dec 28.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.

Objectives: To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) agents and corticosteroids for the treatment of macular oedema (ME) secondary to central retinal vein occlusion (CRVO).

Design: Systematic review and network meta-analysis.

Participants: Patients from previously reported randomised controlled trials (RCTs) comparing anti-VEGF and corticosteroids for the treatment of ME secondary to CRVO. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02270
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http://dx.doi.org/10.1136/bmjopen-2018-022700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318534PMC
December 2018
3 Reads

Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria.

Chem Biol Drug Des 2019 Apr 19;93(4):647-652. Epub 2019 Feb 19.

Department of Pharmacology, University of California, San Diego, La Jolla, California.

To maintain the lipid asymmetry of the cell envelope in Gram-negative bacteria, the MlaC protein serves as a lipid transfer factor and delivers phospholipids from the outer to the inner membrane. A strategy of antibiotic discovery is to design a proper compound that can tightly bind to the MlaC protein and inhibit the MlaC function. In this study, we performed virtual screening on multiple MlaC structures obtained from molecular dynamics simulations to identify potential MlaC binders. Read More

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http://dx.doi.org/10.1111/cbdd.13462DOI Listing

Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and Systemic Serious Adverse Events.

Ophthalmol Retina 2018 Feb;2(2):118-127

Centre for Experimental Medicine, Queen's University, Belfast, United Kingdom.

Purpose: To describe serum vascular endothelial growth factor (sVEGF) in patients with neovascular age-related macular degeneration (nAMD) receiving anti-VEGF agents and associations between sVEGF and systemic serious adverse events (SSAEs).

Design: Exploratory analyses of a randomized controlled trial that enrolled 610 participants with nAMD and compared 2 anti-VEGF antibodies, ranibizumab and bevacizumab, and 2 treatment regimens, monthly vs. discontinuous, with 2 years' follow-up. Read More

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http://dx.doi.org/10.1016/j.oret.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278944PMC
February 2018
7 Reads

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

Ital J Pediatr 2018 Dec 4;44(1):146. Epub 2018 Dec 4.

Institute of Pediatrics, University of Palermo, Palermo, Italy.

Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy, CNR (National Research Council) underlined how over 17 million, 42.8% of the population aged 15-64 have a gambling behavior. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0592-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280468PMC
December 2018
12 Reads

Statistical analysis plan for the control of blood pressure and risk attenuation-rural Bangladesh, Pakistan, Sri Lanka (COBRA-BPS) trial: a cluster randomized trial for a multicomponent intervention versus usual care in hypertensive patients.

Trials 2018 Nov 29;19(1):658. Epub 2018 Nov 29.

Duke Global Health Institute, Duke University, Trent Hall, 310 Trent Drive, Durham, NC, USA.

Background: In rural south Asia, hypertension remains a significant public health issue with sub-optimal blood pressure (BP) control rates. The goal of the trial is to evaluate the effectiveness and cost-effectiveness of a multicomponent intervention (MCI) compared to usual care on lowering BP among adults with hypertension in rural south-Asian communities. This article describes the statistical analysis plan for the primary and secondary objectives related to intervention effectiveness based on clinical and patient-reported endpoints. Read More

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http://dx.doi.org/10.1186/s13063-018-3022-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263546PMC
November 2018
3 Reads

The systematic case-referent method.

Therapie 2019 Apr 26;74(2):199-207. Epub 2018 Oct 26.

London School of Hygiene and Tropical Medicine, LA Risk Research, London EC1R 5BD, United Kingdom.

The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. Read More

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http://dx.doi.org/10.1016/j.therap.2018.09.073DOI Listing
April 2019
20 Reads

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency.

Trials 2018 Nov 20;19(1):642. Epub 2018 Nov 20.

Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

Background: In recent years, experience on the application of adaptive designs in confirmatory clinical trials has accumulated. Although planning such trials comes at the cost of additional operational complexity, adaptive designs offer the benefit of flexibility to update trial design and objectives as data accrue. In 2007, the European Medicines Agency (EMA) provided guidance on confirmatory clinical trials with adaptive (or flexible) designs. Read More

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http://dx.doi.org/10.1186/s13063-018-3012-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245528PMC
November 2018
31 Reads

Cholinesterase Inhibitory Activities of Selected Halogenated Thiophene Chalcones.

Cent Nerv Syst Agents Med Chem 2019 ;19(1):67-71

Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad-678557, Kerala, India.

Background: Dual-acting human monoamine oxidase B (hMAO-B) and cholinesterase (ChE) inhibitors are more effective than the classic one-drug one-target therapy for Alzheimer's disease (AD).

Methods: The ChE inhibitory ability of some halogenated thiophene chalcone-based molecules known to be selective hMAO-B inhibitors was evaluated.

Results: Based on the IC50 values, the selected compounds were found to moderately inhibit ChE, with IC50 values in the range of 14-70 µM. Read More

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http://dx.doi.org/10.2174/1871524918666181119114016DOI Listing
January 2019
15 Reads

Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer.

Mol Cancer 2018 10 31;17(1):156. Epub 2018 Oct 31.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression. One such possible new target is YWHAZ of the 14-3-3 protein family as this gene has prognostic significance for metastatic CRPC patients. However, there are no small molecules targeting YWHAZ commercially available. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0905-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208026PMC
October 2018
2 Reads

Prognostic Implication of the United States Food and Drug Administration-defined BCG-unresponsive Disease.

Eur Urol 2019 01 6;75(1):8-10. Epub 2018 Oct 6.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

The category "BCG-unresponsive disease", formulated by experts at the request of the United States Food and Drug Administration, denotes a group of patients with recurrent non-muscle-invasive bladder cancer for whom continued BCG treatment is unlikely to provide benefit. Although quickly adopted for trial design, many of the nuances within the definition lack validation. In this study, we evaluated the prognostic value of BCG unresponsive designation (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183071
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http://dx.doi.org/10.1016/j.eururo.2018.09.028DOI Listing
January 2019
1 Read

Comparative, cross-sectional study of the format, content and timing of medication safety letters issued in Canada, the USA and the UK.

BMJ Open 2018 Oct 8;8(10):e020150. Epub 2018 Oct 8.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

Objectives: To assess consistency in the format and content, and overlap of subject and timing, of medication safety letters issued by regulatory health authorities to healthcare providers in Canada, the USA and the UK.

Design: A cross-sectional study comparing medication safety letters issued for the purpose of alerting healthcare providers to newly identified medication problems associated with medications already on the market.

Setting: Online databases operated by Health Canada, the US Food and Drug Administration and the UK Medicines and Healthcare products Regulatory Agency were searched to select medication safety letters issued between 1 January 2010 and 31 December 2014. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-02015
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http://dx.doi.org/10.1136/bmjopen-2017-020150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194396PMC
October 2018
7 Reads

Treatment of pustular psoriasis with anakinra: a statistical analysis plan for stage 1 of an adaptive two-staged randomised placebo-controlled trial.

Trials 2018 Oct 3;19(1):534. Epub 2018 Oct 3.

Imperial Clinical Trials Unit, School of Public Health, Imperial College London, Stadium House, 68 Wood Lane, London, W12 7RH, UK.

Background: Palmoplantar pustulosis (PPP) is a rare, chronic inflammatory skin disease. It is known to affect quality of life at a level comparable to that from major medical and psychiatric illness, yet current treatment options are remarkably limited. Recent evidence however suggests that interleukin-1 (IL-1) blockade with anakinra will deliver therapeutic benefit in PPP. Read More

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http://dx.doi.org/10.1186/s13063-018-2914-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169096PMC
October 2018
7 Reads

A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial.

Trials 2018 Sep 19;19(1):507. Epub 2018 Sep 19.

Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Several studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanisms of death in Chagas heart disease. The impact of specific etiologic treatment on the prognosis of patients with chronic Chagas heart disease is very limited regardless of the presence or absence of heart failure. Read More

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http://dx.doi.org/10.1186/s13063-018-2889-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147028PMC
September 2018
21 Reads

Magneto low-density nanoemulsion (MLDE): A potential vehicle for combined hyperthermia and photodynamic therapy to treat cancer selectively.

Mater Sci Eng C Mater Biol Appl 2018 Nov 20;92:103-111. Epub 2018 Jun 20.

Department of Chemistry, Center of Nanotechnologyand Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Brazil. Electronic address:

In this paper, we introduce a new drug delivery system (DDS) called magneto low-density nanoemulsion (MLDE), which can carry maghemite nanoparticles and Chlorin e6 as an active photosensitizer drug. This design can enhance tumor damage after minor heat dissipation and/or minimum visible light photosensitization doses by classical magnetic hyperthermia (MHT) and photodynamic therapy (PDT), respectively. We establish protocols to prepare the MLDE and to load the drug combination onto it. Read More

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http://dx.doi.org/10.1016/j.msec.2018.06.033DOI Listing
November 2018

Crushing drugs in geriatric units: are cleaning methods and devices appropriate?

Eur J Clin Pharmacol 2019 Jan 31;75(1):127-129. Epub 2018 Aug 31.

Service of Polyvalente Internal Medicine, Rouen University Hospital, Rouen, France.

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http://dx.doi.org/10.1007/s00228-018-2547-9DOI Listing
January 2019
8 Reads

Conbercept for Treatment of Neovascular Age-related Macular Degeneration: Results of the Randomized Phase 3 PHOENIX Study.

Am J Ophthalmol 2019 Jan 24;197:156-167. Epub 2018 Aug 24.

Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. Electronic address:

Purpose: Age-related macular degeneration (AMD) can cause irreversible vision loss leading to blindness. We aim to evaluate the efficacy and safety of intravitreal injections of 0.5 mg conbercept, a new anti-vascular endothelial growth factor (anti-VEGF) drug, for treatment of AMD on a schedule more manageable for patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183047
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http://dx.doi.org/10.1016/j.ajo.2018.08.026DOI Listing
January 2019
14 Reads

Design and synthesis of 5-(5-nitrothiophen-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazole derivatives with improved solubility and potential antituberculosis activity.

Chem Biol Drug Des 2019 Jan 8;93(1):84-88. Epub 2018 Oct 8.

Tuberculosis Immunology and Immunoassay Development Section, Radiation Medicine Centre-BARC, Tata Memorial Hospital, Mumbai, India.

We report the design-synthesis of several nitrothiophene containing molecules as antituberculosis agents. The molecules were designed on the basis of previously reported nitrofuran molecules in our laboratory, and the α,β-unsaturated linker was modified to cyclized linker in order to overcome the challenge of low solubility and possible toxicity. The stereo-electronic properties such as HOMO, LUMO, and HOMO-LUMO gap along with other properties such as aqueous solvation energies and QPLogS values were studied. Read More

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http://dx.doi.org/10.1111/cbdd.13386DOI Listing
January 2019
2 Reads

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates.

ACS Chem Biol 2018 09 27;13(9):2427-2432. Epub 2018 Aug 27.

Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London SM2 5NG , U.K.

APOBEC3B (A3B) deamination activity on ssDNA is considered a contributing factor to tumor heterogeneity and drug resistance in a number of human cancers. Despite its clinical impact, little is known about A3B ssDNA substrate preference. We have used nuclear magnetic resonance to monitor the catalytic turnover of A3B substrates in real-time. Read More

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http://dx.doi.org/10.1021/acschembio.8b00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430498PMC
September 2018
4 Reads

Effect of glycosylated hemoglobin on response to ranibizumab therapy in diabetic macular edema: real-world outcomes in 312 patients.

Can J Ophthalmol 2018 08 16;53(4):415-419. Epub 2017 Dec 16.

Moorfields Eye Hospital NHS Foundation Trust, London, U.K.

Objective: To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab therapy for diabetic macular edema (DME).

Design: Retrospective cohort study.

Participants: Patients receiving ranibizumab injections for centre-involving DME in a National Health Service setting. Read More

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http://dx.doi.org/10.1016/j.jcjo.2017.10.008DOI Listing
August 2018
1 Read

Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema in a Real-World Clinical Setting.

Am J Ophthalmol 2018 Nov 9;195:209-222. Epub 2018 Aug 9.

Sacro Cuore Don Calabria Hospital, Verona, Italy.

Purpose: To report the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) in a real-world clinical setting and to assess the efficacy of subsequent alternative treatments in eyes with suboptimal response to anti-VEGF.

Design: Retrospective interventional case series.

Methods: The medical records of consecutive eyes with center-involving DME, treated between August 2008 and June 2015 with 3 monthly intravitreal anti-VEGF injections-with or without prompt or deferred laser-followed by pro re nata re-treatment, were reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183044
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http://dx.doi.org/10.1016/j.ajo.2018.08.004DOI Listing
November 2018
9 Reads

Early Response to Anti-Vascular Endothelial Growth Factor and Two-Year Outcomes Among Eyes With Diabetic Macular Edema in Protocol T.

Am J Ophthalmol 2018 Nov 2;195:93-100. Epub 2018 Aug 2.

Palmetto Retina Center, Columbia, South Carolina, USA.

Purpose: Assess associations of 2-year visual acuity (VA) outcomes with VA and optical coherence tomography central subfield thickness (CST) after 12 weeks of anti-vascular endothelial growth factor treatment for diabetic macular edema in DRCR.net Protocol T.

Design: Randomized clinical trial. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.07.030DOI Listing
November 2018
4 Reads
3.871 Impact Factor

One year effectiveness study of intravitreal aflibercept in neovascular age-related macular degeneration: a meta-analysis.

Acta Ophthalmol 2019 Feb 21;97(1):e1-e7. Epub 2018 Jul 21.

Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.

The current body of evidence on the efficacy and safety of aflibercept for age-related macular degeneration (AMD) is steadily growing as large clinical trials and observational studies are continually completed. Our aim was to analyse 1-year visual acuity (VA) outcomes in response to aflibercept therapy and identify factors affecting treatment response using evidence generated from a pooled analysis of current studies. A literature review of multiple electronic databases (EMBASE, MEDLINE, MedMEME) revealed 12 studies meeting inclusion and exclusion criteria for statistical analysis. Read More

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http://dx.doi.org/10.1111/aos.13825DOI Listing
February 2019
5 Reads

Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: study protocol of a randomised controlled trial to evaluate the effect of short message service (SMS) reminder.

BMC Cancer 2018 Jul 9;18(1):727. Epub 2018 Jul 9.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-03F, Singapore, 117549, Singapore.

Background: Medication adherence refers to whether a patient takes medication according to the frequency prescribed, or continues to take a prescribed medication. Inadequate adherence to medication may cause alterations in risk-benefit ratios, resulting in reduced benefits, increased risks or both, and is significantly associated with adverse clinical outcomes and higher healthcare costs. We aim to examine the effect of a computer generated short message service (SMS) reminder in improving medication adherence, and inhibiting the aromatisation process amongst breast cancer women receiving oral aromatase inhibitor therapy. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4660-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038248PMC
July 2018
18 Reads

The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials.

Clin Pharmacol Ther 2018 Nov 14;104(5):797. Epub 2018 Jul 14.

Certara QSP, Canterbury Innovation Centre, Canterbury, UK.

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http://dx.doi.org/10.1002/cpt.1145DOI Listing
November 2018
1 Read

Getting personal with the "reproducibility crisis": interviews in the animal research community.

Lab Anim (NY) 2018 07;47(7):175-177

Tempest Technologies, Los Angeles, California, United States.

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http://www.nature.com/articles/s41684-018-0088-6
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http://dx.doi.org/10.1038/s41684-018-0088-6DOI Listing
July 2018
2 Reads

Mobile health applications in cardiovascular research.

Int J Cardiol 2018 Oct 12;269:265-271. Epub 2018 Jun 12.

Cardiology Division, Stony Brook University, Stony Brook, New York, United States. Electronic address:

Cardiovascular disease is the leading cause of mortality and morbidity globally. With widespread and growing use of smart phones and mobile devices, the use of mobile health (mHealth) in transmission of physiologic parameters and patient-referred symptoms to healthcare providers and researchers, as well as reminders and care plan applications from providers to patients, has potential to revolutionize both clinical care and the conduct of clinical trials with improved designs, data capture, and potentially lower costs. In randomized early phase proof-of-concept studies, focusing on lifestyle intervention, there is evidence that mHealth technology can improve outcomes. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.06.039DOI Listing
October 2018
22 Reads
4.040 Impact Factor

A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema.

Invest Ophthalmol Vis Sci 2018 05;59(6):2659-2669

Inflammation and Immunology Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States.

Purpose: Ligands for the proinflammatory C-C chemokine receptor types 2 and 5 (CCR2 and CCR5) are elevated in the eyes of patients with diabetic macular edema (DME). We evaluated the efficacy and safety of PF-04634817, an oral CCR2/5 dual antagonist, versus intravitreal ranibizumab, in adult subjects with DME.

Methods: In this phase II, randomized, placebo-controlled, double-masked study, eligible subjects (≥18 years of age) had type 1 or 2 diabetes and DME with best-corrected visual acuity (BCVA) of 20/32 or worse (letter score ≤ 78), and up to 20/320 or better (≥24 letter score), in the study eye. Read More

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http://dx.doi.org/10.1167/iovs.17-22731DOI Listing
May 2018
1 Read

Bioinspired Synergy Sensor Chip of Photonic Crystals-Graphene Oxide for Multiamines Recognition.

Anal Chem 2018 06 21;90(11):6371-6375. Epub 2018 May 21.

Key Laboratory of Green Printing, Institute of Chemistry , Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, Beijing National Laboratory for Molecular Sciences (BNLMS) , Beijing 100190 , China.

Benefiting from the integrated functions of cilia and glomeruli in the olfactory system, animals can discriminate various odors even in hostile environments. Inspired by this synergetic system of response and signal processing units, a sensor chip of graphene oxide (GO) and photonic crystals (PCs) is fabricated. The GO aerogel functions like the olfactory cilia, which effectively captures the analytes and generates abundant sensing signals for recognition; and the PCs act as the olfactory glomeruli, whose periodic structure enables selective enhancement of the fluorescent signals to realize further signal processing. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b01549DOI Listing
June 2018
7 Reads
5.640 Impact Factor

Effectiveness of text message based, diabetes self management support programme (SMS4BG): two arm, parallel randomised controlled trial.

BMJ 2018 05 17;361:k1959. Epub 2018 May 17.

Auckland Diabetes Centre, Greenlane Clinical Centre, Auckland, New Zealand.

Objective: To determine the effectiveness of a theoretically based and individually tailored, text message based, diabetes self management support intervention (SMS4BG) in adults with poorly controlled diabetes.

Design: Nine month, two arm, parallel randomised controlled trial.

Setting: Primary and secondary healthcare services in New Zealand. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957049PMC
http://dx.doi.org/10.1136/bmj.k1959DOI Listing
May 2018
6 Reads

Pragmatic randomised clinical trials using electronic health records: general practitioner views on a model of a priori consent.

Trials 2018 May 16;19(1):278. Epub 2018 May 16.

Medical Research Institute of New Zealand, Private Bag 7902, Wellington, 6242, New Zealand.

Pragmatic randomised clinical trials could use existing electronic health records (EHRs) to identify trial participants, perform randomisation, and to collect follow-up data. Achieving adequate informed consent in routine care and clinician recruitment have been identified as key barriers to this approach to clinical trials. We propose a model where written informed consent for a pragmatic comparative effectiveness trial is obtained in advance by the research team, recorded in the EHR, and then confirmed by the general practitioner (GP) at the time of enrolment. Read More

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http://dx.doi.org/10.1186/s13063-018-2658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956547PMC
May 2018
2 Reads

Individual Negative Affective Trajectories Can Be Detected during Different Depressive Relapse Prevention Strategies.

Psychother Psychosom 2018 14;87(4):243-245. Epub 2018 May 14.

Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1159/000489044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159830PMC
November 2018
1 Read

Evaluation of aluminum phthalocyanine chloride and DNA interactions for the design of an advanced drug delivery system in photodynamic therapy.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Aug 5;201:242-248. Epub 2018 May 5.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Av. dos Bandeirantes 3900, 14040-901, Vila Monte Alegre, University of São Paulo, Brazil. Electronic address:

The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. Read More

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http://dx.doi.org/10.1016/j.saa.2018.05.009DOI Listing
August 2018
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Optimization of Human Semen Extender Components for Cryopreservation Using Statistical Tools.

Cryo Letters 2017 Nov/Dec;38(6):434-444

School of Biosciences and Technology, VIT University, Near Katpadi Road, Vellore, Tamil Nadu, India.

  BACKGROUND: Human sperm cell preservation is an important part of assisted reproductive technology (ART).

Objective: This study aimed to find the essential and significant components in semen preservation extender required to prolong the shelf life of human spermatozoa.

Materials And Methods: By using the statistical tool 'Plackett-Burman design' the significant components present in E4 extender (formulated in our previous study) was determined by reducing the unacceptable large number of trial experiments from the full factorial method. Read More

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Canonical correlation analysis to identify the semen characteristics used to forecast the freeze survival of Curimba (Prochilodus lineatus) spermatozoa.

Cryo Letters 2017 Jul/Aug;38(4):263-268

Departament of Animal Production, School of Veterinary and Zootechny, Federal University of Goias, Brazil.

  OBJECTIVE: To identify which sperm characteristics were able to predict more accurately the quality of curimba (Prochilodus lineatus) semen upon freezing using canonical correlation analysis.

Methods: Eleven fish breeders with initial mean weight of 705.21 ± 111 g were used. Read More

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A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.

FEBS Lett 2018 06 22;592(11):1837-1846. Epub 2018 May 22.

School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, China.

Uridine diphosphate-glucuronosyltransferases (UGTs) are the most important phase II enzymes in human drug metabolism. Using permeabilized recombinant fission yeast cells (enzyme bags), we demonstrate that UGT1A5 can catalyze an N-glucuronidation reaction. We characterized two new polymorphic UGT1A5 variants: a common ninefold mutant (UGT1A5*8) with double-fold activity and a much rarer sixfold mutant (UGT1A5*9), which has the same activity as the wild-type. Read More

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http://doi.wiley.com/10.1002/1873-3468.13072
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http://dx.doi.org/10.1002/1873-3468.13072DOI Listing
June 2018
6 Reads

Layer-by-layer hollow photosensitizer microcapsule design via a manganese carbonate hard template for photodynamic therapy in cells.

Photodiagnosis Photodyn Ther 2018 Jun 20;22:169-177. Epub 2018 Apr 20.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Av. dos Bandeirantes 3900, 14040-901, Vila Monte Alegre, University of São Paulo, Brazil. Electronic address:

Background: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.04.011DOI Listing
June 2018
5 Reads

Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema.

Cochrane Database Syst Rev 2018 04 18;4:CD011599. Epub 2018 Apr 18.

Royal Free London NHS Foundation Trust, London, UK.

Background: The combination of steroid and anti-vascular endothelial growth factor (VEGF) intravitreal therapeutic agents could potentially have synergistic effects for treating diabetic macular oedema (DMO). On the one hand, if combined treatment is more effective than monotherapy, there would be significant implications for improving patient outcomes. Conversely, if there is no added benefit of combination therapy, then people could be potentially exposed to unnecessary local or systemic side effects. Read More

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http://dx.doi.org/10.1002/14651858.CD011599.pub2DOI Listing
April 2018
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HABIT, a Randomized Feasibility Trial to Increase Hydroxyurea Adherence, Suggests Improved Health-Related Quality of Life in Youths with Sickle Cell Disease.

J Pediatr 2018 06 20;197:177-185.e2. Epub 2018 Mar 20.

Department of Pediatrics, Columbia University Medical Center, New York, NY.

Objectives: To examine the effect of a community health worker (CHW) intervention, augmented by tailored text messages, on adherence to hydroxyurea therapy in youths with sickle cell disease, as well as on generic and disease-specific health-related quality of life (HrQL) and youth-parent self-management responsibility concordance.

Study Design: We conducted a 2-site randomized controlled feasibility study (Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment [HABIT]) with 2:1 intervention allocation. Youths and parents participated as dyads. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.01.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970970PMC
June 2018
1 Read

Bioresorbable polymer drug-eluting stents.

Lancet 2018 03;391(10124):936

Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183053
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http://dx.doi.org/10.1016/S0140-6736(18)30532-4DOI Listing
March 2018
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Bioresorbable polymer drug-eluting stents - Authors' reply.

Lancet 2018 03;391(10124):936-937

Division of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, DC, USA.

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http://dx.doi.org/10.1016/S0140-6736(18)30535-XDOI Listing
March 2018
3 Reads

Bioresorbable polymer drug-eluting stents.

Authors:
Rahman Shah

Lancet 2018 03;391(10124):935-936

University of Tennessee, School of Medicine, Section of Cardiovascular Medicine, Veterans Affairs Medical Center, Memphis, TN 38104, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)30528-2DOI Listing

Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.

FEBS Lett 2018 04 11;592(8):1445-1457. Epub 2018 Apr 11.

School of Stomatology and Medicine, Foshan University, China.

Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T- and B cells conserved across mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG_0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. Read More

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http://dx.doi.org/10.1002/1873-3468.13024DOI Listing
April 2018
9 Reads

Impact of post-dilatation on strut apposition of second-generation bioresorbable vascular scaffolds: Key role for scaffold thrombosis and prognosis?

Cardiol J 2018 ;25(1):148-150

Medical University of Gdansk, Gdansk, Poland University Hospital of Zurich, Zurich, Switzerland Institute for Cardiovascular Translational Research of the Atlantic, Spain.

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http://dx.doi.org/10.5603/CJ.2018.0013DOI Listing
November 2018
5 Reads

Head-to-head comparison of the accuracy of Abbott FreeStyle Libre and Dexcom G5 mobile.

Nutr Metab Cardiovasc Dis 2018 04 31;28(4):425-427. Epub 2018 Jan 31.

Division of Metabolic Diseases, Department of Medicine, University of Padova, Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.numecd.2018.01.003DOI Listing

Hospitalization Drug Regimen Changes in Geriatric Patients and Adherence to Modifications by General Practitioners in Primary Care.

J Nutr Health Aging 2018 ;22(3):328-334

Laure Rouch,Toulouse University Hospital, Department of Pharmacy, France,

Objectives: To evaluate the overall rate of adherence by general practitioners (GPs) to treatment modifications suggested at discharge from hospital and to assess the way communication between secondary and primary care could be improved.

Design: Observational prospective cohort study.

Setting: Patients hospitalized from the emergency department to the acute geriatric care unit of a university hospital. Read More

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http://dx.doi.org/10.1007/s12603-017-0940-1DOI Listing
January 2018
8 Reads

Potential link between sporadic cerebral amyloid angiopathy and vision loss: a case report.

Acta Ophthalmol 2018 Sep 20;96(6):e753-e755. Epub 2018 Feb 20.

Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.

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http://dx.doi.org/10.1111/aos.13681DOI Listing
September 2018
3 Reads

Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.

ACS Comb Sci 2018 04 26;20(4):192-196. Epub 2018 Feb 26.

University of Groningen , Department of Drug Design , A. Deusinglaan 1 , 9713 AV Groningen , The Netherlands.

The synthesis of uracil/thymine containing tetra/trisubstituted imidazole derivatives was demonstrated using Ugi/Passerini-reaction followed by a postcyclization reaction sequence. The approach enables the one-pot facile construction of diverse compounds in moderate to excellent yields (47-82%). The 5-fluorouracil and 5-methyluracil moieties afford potentially bioactive molecules with drug-like properties. Read More

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http://dx.doi.org/10.1021/acscombsci.7b00145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894062PMC
April 2018
6 Reads