3,735 results match your criteria Letters in Drug Design & Discovery[Journal]


Chronic obstructive pulmonary disease (COPD) among opioid dependent patients in agonist treatment. A diagnostic study.

Addiction 2019 Jan 24. Epub 2019 Jan 24.

Arud Centre for Addiction Medicine, Schützengasse 31, CH-8001, Zurich.

Aims: To estimate the prevalence of chronic obstructive pulmonary disease (COPD) and related risk factors in persons in opioid agonist treatment (OAT), to compare airflow limitation severity and age-specific COPD prevalence rates with those in the general population, and to assess the OAT patients' willingness to adopt lifestyle changes and to use therapeutic offers for COPD management.

Design: Cross-sectional study in a random sample of OAT patients.

Setting: Outpatient centres for substance addiction medicine in Zurich, Switzerland. Read More

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http://doi.wiley.com/10.1111/add.14559
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http://dx.doi.org/10.1111/add.14559DOI Listing
January 2019
9 Reads

Comparison of the efficacy and safety of drug therapies for macular edema secondary to central retinal vein occlusion.

BMJ Open 2018 Dec 28;8(12):e022700. Epub 2018 Dec 28.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.

Objectives: To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) agents and corticosteroids for the treatment of macular oedema (ME) secondary to central retinal vein occlusion (CRVO).

Design: Systematic review and network meta-analysis.

Participants: Patients from previously reported randomised controlled trials (RCTs) comparing anti-VEGF and corticosteroids for the treatment of ME secondary to CRVO. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02270
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http://dx.doi.org/10.1136/bmjopen-2018-022700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318534PMC
December 2018
1 Read

Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria.

Chem Biol Drug Des 2018 Dec 20. Epub 2018 Dec 20.

Department of Pharmacology, University of California, San Diego, La Jolla, California.

To maintain the lipid asymmetry of the cell envelope in Gram-negative bacteria, the MlaC protein serves as a lipid transfer factor and delivers phospholipids from the outer to the inner membrane. A strategy of antibiotic discovery is to design a proper compound that can tightly bind to the MlaC protein and inhibit the MlaC function. In this study, we performed virtual screening on multiple MlaC structures obtained from molecular dynamics simulations to identify potential MlaC binders. Read More

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http://dx.doi.org/10.1111/cbdd.13462DOI Listing
December 2018

Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and Systemic Serious Adverse Events.

Ophthalmol Retina 2018 Feb;2(2):118-127

Centre for Experimental Medicine, Queen's University, Belfast, United Kingdom.

Purpose: To describe serum vascular endothelial growth factor (sVEGF) in patients with neovascular age-related macular degeneration (nAMD) receiving anti-VEGF agents and associations between sVEGF and systemic serious adverse events (SSAEs).

Design: Exploratory analyses of a randomized controlled trial that enrolled 610 participants with nAMD and compared 2 anti-VEGF antibodies, ranibizumab and bevacizumab, and 2 treatment regimens, monthly vs. discontinuous, with 2 years' follow-up. Read More

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http://dx.doi.org/10.1016/j.oret.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278944PMC
February 2018
2 Reads

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

Ital J Pediatr 2018 Dec 4;44(1):146. Epub 2018 Dec 4.

Institute of Pediatrics, University of Palermo, Palermo, Italy.

Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy, CNR (National Research Council) underlined how over 17 million, 42.8% of the population aged 15-64 have a gambling behavior. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0592-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280468PMC
December 2018
7 Reads

The systematic case-referent method.

Therapie 2018 Oct 26. Epub 2018 Oct 26.

London School of Hygiene and Tropical Medicine, LA Risk Research, London EC1R 5BD, United Kingdom.

The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. Read More

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http://dx.doi.org/10.1016/j.therap.2018.09.073DOI Listing
October 2018
15 Reads

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency.

Trials 2018 Nov 20;19(1):642. Epub 2018 Nov 20.

Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

Background: In recent years, experience on the application of adaptive designs in confirmatory clinical trials has accumulated. Although planning such trials comes at the cost of additional operational complexity, adaptive designs offer the benefit of flexibility to update trial design and objectives as data accrue. In 2007, the European Medicines Agency (EMA) provided guidance on confirmatory clinical trials with adaptive (or flexible) designs. Read More

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http://dx.doi.org/10.1186/s13063-018-3012-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245528PMC
November 2018
25 Reads

Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer.

Mol Cancer 2018 10 31;17(1):156. Epub 2018 Oct 31.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression. One such possible new target is YWHAZ of the 14-3-3 protein family as this gene has prognostic significance for metastatic CRPC patients. However, there are no small molecules targeting YWHAZ commercially available. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0905-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208026PMC
October 2018
2 Reads

Prognostic Implication of the United States Food and Drug Administration-defined BCG-unresponsive Disease.

Eur Urol 2019 01 6;75(1):8-10. Epub 2018 Oct 6.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

The category "BCG-unresponsive disease", formulated by experts at the request of the United States Food and Drug Administration, denotes a group of patients with recurrent non-muscle-invasive bladder cancer for whom continued BCG treatment is unlikely to provide benefit. Although quickly adopted for trial design, many of the nuances within the definition lack validation. In this study, we evaluated the prognostic value of BCG unresponsive designation (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183071
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http://dx.doi.org/10.1016/j.eururo.2018.09.028DOI Listing
January 2019
1 Read

Comparative, cross-sectional study of the format, content and timing of medication safety letters issued in Canada, the USA and the UK.

BMJ Open 2018 Oct 8;8(10):e020150. Epub 2018 Oct 8.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

Objectives: To assess consistency in the format and content, and overlap of subject and timing, of medication safety letters issued by regulatory health authorities to healthcare providers in Canada, the USA and the UK.

Design: A cross-sectional study comparing medication safety letters issued for the purpose of alerting healthcare providers to newly identified medication problems associated with medications already on the market.

Setting: Online databases operated by Health Canada, the US Food and Drug Administration and the UK Medicines and Healthcare products Regulatory Agency were searched to select medication safety letters issued between 1 January 2010 and 31 December 2014. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-02015
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http://dx.doi.org/10.1136/bmjopen-2017-020150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194396PMC
October 2018
3 Reads

Fresh thoughts and perspectives on CARES study from viewpoint of an Asian physician: comment on the article by Choi et al.

Arthritis Rheumatol 2018 Oct 8. Epub 2018 Oct 8.

Institute of Metabolic Diseases, Qingdao University, Qingdao, China.

Following the report of CARES study published on NEJM and associated U.S. FDA's safety alert concerning febuxostat for management of hyperuricemia in gout, Choi et al. Read More

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http://doi.wiley.com/10.1002/art.40741
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http://dx.doi.org/10.1002/art.40741DOI Listing
October 2018
7 Reads

Treatment of pustular psoriasis with anakinra: a statistical analysis plan for stage 1 of an adaptive two-staged randomised placebo-controlled trial.

Trials 2018 Oct 3;19(1):534. Epub 2018 Oct 3.

Imperial Clinical Trials Unit, School of Public Health, Imperial College London, Stadium House, 68 Wood Lane, London, W12 7RH, UK.

Background: Palmoplantar pustulosis (PPP) is a rare, chronic inflammatory skin disease. It is known to affect quality of life at a level comparable to that from major medical and psychiatric illness, yet current treatment options are remarkably limited. Recent evidence however suggests that interleukin-1 (IL-1) blockade with anakinra will deliver therapeutic benefit in PPP. Read More

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http://dx.doi.org/10.1186/s13063-018-2914-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169096PMC
October 2018
7 Reads

A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial.

Trials 2018 Sep 19;19(1):507. Epub 2018 Sep 19.

Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Several studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanisms of death in Chagas heart disease. The impact of specific etiologic treatment on the prognosis of patients with chronic Chagas heart disease is very limited regardless of the presence or absence of heart failure. Read More

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http://dx.doi.org/10.1186/s13063-018-2889-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147028PMC
September 2018
18 Reads

Magneto low-density nanoemulsion (MLDE): A potential vehicle for combined hyperthermia and photodynamic therapy to treat cancer selectively.

Mater Sci Eng C Mater Biol Appl 2018 Nov 20;92:103-111. Epub 2018 Jun 20.

Department of Chemistry, Center of Nanotechnologyand Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Brazil. Electronic address:

In this paper, we introduce a new drug delivery system (DDS) called magneto low-density nanoemulsion (MLDE), which can carry maghemite nanoparticles and Chlorin e6 as an active photosensitizer drug. This design can enhance tumor damage after minor heat dissipation and/or minimum visible light photosensitization doses by classical magnetic hyperthermia (MHT) and photodynamic therapy (PDT), respectively. We establish protocols to prepare the MLDE and to load the drug combination onto it. Read More

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http://dx.doi.org/10.1016/j.msec.2018.06.033DOI Listing
November 2018

Conbercept for Treatment of Neovascular Age-related Macular Degeneration: Results of the Randomized Phase 3 PHOENIX Study.

Am J Ophthalmol 2019 Jan 24;197:156-167. Epub 2018 Aug 24.

Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. Electronic address:

Purpose: Age-related macular degeneration (AMD) can cause irreversible vision loss leading to blindness. We aim to evaluate the efficacy and safety of intravitreal injections of 0.5 mg conbercept, a new anti-vascular endothelial growth factor (anti-VEGF) drug, for treatment of AMD on a schedule more manageable for patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183047
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http://dx.doi.org/10.1016/j.ajo.2018.08.026DOI Listing
January 2019
12 Reads

Design and synthesis of 5-(5-nitrothiophen-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazole derivatives with improved solubility and potential antituberculosis activity.

Chem Biol Drug Des 2019 Jan 8;93(1):84-88. Epub 2018 Oct 8.

Tuberculosis Immunology and Immunoassay Development Section, Radiation Medicine Centre-BARC, Tata Memorial Hospital, Mumbai, India.

We report the design-synthesis of several nitrothiophene containing molecules as antituberculosis agents. The molecules were designed on the basis of previously reported nitrofuran molecules in our laboratory, and the α,β-unsaturated linker was modified to cyclized linker in order to overcome the challenge of low solubility and possible toxicity. The stereo-electronic properties such as HOMO, LUMO, and HOMO-LUMO gap along with other properties such as aqueous solvation energies and QPLogS values were studied. Read More

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http://dx.doi.org/10.1111/cbdd.13386DOI Listing
January 2019
1 Read

Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema in a Real-World Clinical Setting.

Am J Ophthalmol 2018 Nov 9;195:209-222. Epub 2018 Aug 9.

Sacro Cuore Don Calabria Hospital, Verona, Italy.

Purpose: To report the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) in a real-world clinical setting and to assess the efficacy of subsequent alternative treatments in eyes with suboptimal response to anti-VEGF.

Design: Retrospective interventional case series.

Methods: The medical records of consecutive eyes with center-involving DME, treated between August 2008 and June 2015 with 3 monthly intravitreal anti-VEGF injections-with or without prompt or deferred laser-followed by pro re nata re-treatment, were reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183044
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http://dx.doi.org/10.1016/j.ajo.2018.08.004DOI Listing
November 2018
9 Reads

Early Response to Anti-Vascular Endothelial Growth Factor and Two-Year Outcomes Among Eyes With Diabetic Macular Edema in Protocol T.

Am J Ophthalmol 2018 Nov 2;195:93-100. Epub 2018 Aug 2.

Palmetto Retina Center, Columbia, South Carolina, USA.

Purpose: Assess associations of 2-year visual acuity (VA) outcomes with VA and optical coherence tomography central subfield thickness (CST) after 12 weeks of anti-vascular endothelial growth factor treatment for diabetic macular edema in DRCR.net Protocol T.

Design: Randomized clinical trial. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.07.030DOI Listing
November 2018
3 Reads
3.871 Impact Factor

One year effectiveness study of intravitreal aflibercept in neovascular age-related macular degeneration: a meta-analysis.

Acta Ophthalmol 2019 Feb 21;97(1):e1-e7. Epub 2018 Jul 21.

Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.

The current body of evidence on the efficacy and safety of aflibercept for age-related macular degeneration (AMD) is steadily growing as large clinical trials and observational studies are continually completed. Our aim was to analyse 1-year visual acuity (VA) outcomes in response to aflibercept therapy and identify factors affecting treatment response using evidence generated from a pooled analysis of current studies. A literature review of multiple electronic databases (EMBASE, MEDLINE, MedMEME) revealed 12 studies meeting inclusion and exclusion criteria for statistical analysis. Read More

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http://dx.doi.org/10.1111/aos.13825DOI Listing
February 2019
4 Reads

Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: study protocol of a randomised controlled trial to evaluate the effect of short message service (SMS) reminder.

BMC Cancer 2018 Jul 9;18(1):727. Epub 2018 Jul 9.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-03F, Singapore, 117549, Singapore.

Background: Medication adherence refers to whether a patient takes medication according to the frequency prescribed, or continues to take a prescribed medication. Inadequate adherence to medication may cause alterations in risk-benefit ratios, resulting in reduced benefits, increased risks or both, and is significantly associated with adverse clinical outcomes and higher healthcare costs. We aim to examine the effect of a computer generated short message service (SMS) reminder in improving medication adherence, and inhibiting the aromatisation process amongst breast cancer women receiving oral aromatase inhibitor therapy. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4660-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038248PMC
July 2018
17 Reads

The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials.

Clin Pharmacol Ther 2018 Nov 14;104(5):797. Epub 2018 Jul 14.

Certara QSP, Canterbury Innovation Centre, Canterbury, UK.

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http://dx.doi.org/10.1002/cpt.1145DOI Listing
November 2018
1 Read

Getting personal with the "reproducibility crisis": interviews in the animal research community.

Lab Anim (NY) 2018 07;47(7):175-177

Tempest Technologies, Los Angeles, California, United States.

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http://www.nature.com/articles/s41684-018-0088-6
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http://dx.doi.org/10.1038/s41684-018-0088-6DOI Listing
July 2018
2 Reads

Effectiveness of text message based, diabetes self management support programme (SMS4BG): two arm, parallel randomised controlled trial.

BMJ 2018 05 17;361:k1959. Epub 2018 May 17.

Auckland Diabetes Centre, Greenlane Clinical Centre, Auckland, New Zealand.

Objective: To determine the effectiveness of a theoretically based and individually tailored, text message based, diabetes self management support intervention (SMS4BG) in adults with poorly controlled diabetes.

Design: Nine month, two arm, parallel randomised controlled trial.

Setting: Primary and secondary healthcare services in New Zealand. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957049PMC
http://dx.doi.org/10.1136/bmj.k1959DOI Listing
May 2018
5 Reads

Pragmatic randomised clinical trials using electronic health records: general practitioner views on a model of a priori consent.

Trials 2018 May 16;19(1):278. Epub 2018 May 16.

Medical Research Institute of New Zealand, Private Bag 7902, Wellington, 6242, New Zealand.

Pragmatic randomised clinical trials could use existing electronic health records (EHRs) to identify trial participants, perform randomisation, and to collect follow-up data. Achieving adequate informed consent in routine care and clinician recruitment have been identified as key barriers to this approach to clinical trials. We propose a model where written informed consent for a pragmatic comparative effectiveness trial is obtained in advance by the research team, recorded in the EHR, and then confirmed by the general practitioner (GP) at the time of enrolment. Read More

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http://dx.doi.org/10.1186/s13063-018-2658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956547PMC
May 2018
2 Reads

Individual Negative Affective Trajectories Can Be Detected during Different Depressive Relapse Prevention Strategies.

Psychother Psychosom 2018 14;87(4):243-245. Epub 2018 May 14.

Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1159/000489044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159830PMC
November 2018
1 Read

Evaluation of aluminum phthalocyanine chloride and DNA interactions for the design of an advanced drug delivery system in photodynamic therapy.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Aug 5;201:242-248. Epub 2018 May 5.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Av. dos Bandeirantes 3900, 14040-901, Vila Monte Alegre, University of São Paulo, Brazil. Electronic address:

The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. Read More

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http://dx.doi.org/10.1016/j.saa.2018.05.009DOI Listing
August 2018
1 Read

Optimization of Human Semen Extender Components for Cryopreservation Using Statistical Tools.

Cryo Letters 2017 Nov/Dec;38(6):434-444

School of Biosciences and Technology, VIT University, Near Katpadi Road, Vellore, Tamil Nadu, India.

  BACKGROUND: Human sperm cell preservation is an important part of assisted reproductive technology (ART).

Objective: This study aimed to find the essential and significant components in semen preservation extender required to prolong the shelf life of human spermatozoa.

Materials And Methods: By using the statistical tool 'Plackett-Burman design' the significant components present in E4 extender (formulated in our previous study) was determined by reducing the unacceptable large number of trial experiments from the full factorial method. Read More

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Canonical correlation analysis to identify the semen characteristics used to forecast the freeze survival of Curimba (Prochilodus lineatus) spermatozoa.

Cryo Letters 2017 Jul/Aug;38(4):263-268

Departament of Animal Production, School of Veterinary and Zootechny, Federal University of Goias, Brazil.

  OBJECTIVE: To identify which sperm characteristics were able to predict more accurately the quality of curimba (Prochilodus lineatus) semen upon freezing using canonical correlation analysis.

Methods: Eleven fish breeders with initial mean weight of 705.21 ± 111 g were used. Read More

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A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.

FEBS Lett 2018 Jun 22;592(11):1837-1846. Epub 2018 May 22.

School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, China.

Uridine diphosphate-glucuronosyltransferases (UGTs) are the most important phase II enzymes in human drug metabolism. Using permeabilized recombinant fission yeast cells (enzyme bags), we demonstrate that UGT1A5 can catalyze an N-glucuronidation reaction. We characterized two new polymorphic UGT1A5 variants: a common ninefold mutant (UGT1A5*8) with double-fold activity and a much rarer sixfold mutant (UGT1A5*9), which has the same activity as the wild-type. Read More

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http://doi.wiley.com/10.1002/1873-3468.13072
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http://dx.doi.org/10.1002/1873-3468.13072DOI Listing
June 2018
5 Reads

Layer-by-layer hollow photosensitizer microcapsule design via a manganese carbonate hard template for photodynamic therapy in cells.

Photodiagnosis Photodyn Ther 2018 Jun 20;22:169-177. Epub 2018 Apr 20.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Av. dos Bandeirantes 3900, 14040-901, Vila Monte Alegre, University of São Paulo, Brazil. Electronic address:

Background: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.04.011DOI Listing
June 2018
5 Reads

Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema.

Cochrane Database Syst Rev 2018 04 18;4:CD011599. Epub 2018 Apr 18.

Royal Free London NHS Foundation Trust, London, UK.

Background: The combination of steroid and anti-vascular endothelial growth factor (VEGF) intravitreal therapeutic agents could potentially have synergistic effects for treating diabetic macular oedema (DMO). On the one hand, if combined treatment is more effective than monotherapy, there would be significant implications for improving patient outcomes. Conversely, if there is no added benefit of combination therapy, then people could be potentially exposed to unnecessary local or systemic side effects. Read More

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http://dx.doi.org/10.1002/14651858.CD011599.pub2DOI Listing
April 2018
12 Reads

Bioresorbable polymer drug-eluting stents.

Lancet 2018 03;391(10124):936

Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183053
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http://dx.doi.org/10.1016/S0140-6736(18)30532-4DOI Listing
March 2018
1 Read

Bioresorbable polymer drug-eluting stents - Authors' reply.

Lancet 2018 03;391(10124):936-937

Division of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, DC, USA.

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http://dx.doi.org/10.1016/S0140-6736(18)30535-XDOI Listing
March 2018
3 Reads

Bioresorbable polymer drug-eluting stents.

Authors:
Rahman Shah

Lancet 2018 03;391(10124):935-936

University of Tennessee, School of Medicine, Section of Cardiovascular Medicine, Veterans Affairs Medical Center, Memphis, TN 38104, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)30528-2DOI Listing

Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.

FEBS Lett 2018 04 11;592(8):1445-1457. Epub 2018 Apr 11.

School of Stomatology and Medicine, Foshan University, China.

Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T- and B cells conserved across mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG_0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. Read More

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http://dx.doi.org/10.1002/1873-3468.13024DOI Listing
April 2018
9 Reads

Impact of post-dilatation on strut apposition of second-generation bioresorbable vascular scaffolds: Key role for scaffold thrombosis and prognosis?

Cardiol J 2018 ;25(1):148-150

Medical University of Gdansk, Gdansk, Poland University Hospital of Zurich, Zurich, Switzerland Institute for Cardiovascular Translational Research of the Atlantic, Spain.

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http://dx.doi.org/10.5603/CJ.2018.0013DOI Listing
November 2018
5 Reads

Hospitalization Drug Regimen Changes in Geriatric Patients and Adherence to Modifications by General Practitioners in Primary Care.

J Nutr Health Aging 2018 ;22(3):328-334

Laure Rouch,Toulouse University Hospital, Department of Pharmacy, France,

Objectives: To evaluate the overall rate of adherence by general practitioners (GPs) to treatment modifications suggested at discharge from hospital and to assess the way communication between secondary and primary care could be improved.

Design: Observational prospective cohort study.

Setting: Patients hospitalized from the emergency department to the acute geriatric care unit of a university hospital. Read More

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http://dx.doi.org/10.1007/s12603-017-0940-1DOI Listing
January 2018
6 Reads

Potential link between sporadic cerebral amyloid angiopathy and vision loss: a case report.

Acta Ophthalmol 2018 Sep 20;96(6):e753-e755. Epub 2018 Feb 20.

Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.

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http://dx.doi.org/10.1111/aos.13681DOI Listing
September 2018
3 Reads

Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.

ACS Comb Sci 2018 04 26;20(4):192-196. Epub 2018 Feb 26.

University of Groningen , Department of Drug Design , A. Deusinglaan 1 , 9713 AV Groningen , The Netherlands.

The synthesis of uracil/thymine containing tetra/trisubstituted imidazole derivatives was demonstrated using Ugi/Passerini-reaction followed by a postcyclization reaction sequence. The approach enables the one-pot facile construction of diverse compounds in moderate to excellent yields (47-82%). The 5-fluorouracil and 5-methyluracil moieties afford potentially bioactive molecules with drug-like properties. Read More

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http://dx.doi.org/10.1021/acscombsci.7b00145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894062PMC
April 2018
6 Reads

Potential benefits of prasugrel and ticagrelor is diabetics are not substantiated by the Food and Drug Administration adverse event repository.

Eur Heart J Cardiovasc Pharmacother 2018 07;4(3):142-143

Central Clinical Hospital of the Administrative Affairs of the President of the Russian Federation, Intensive Cardiology Department, Marshala Timoshenko Ulitsa, 15, Moscow, 121359, Russia.

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https://academic.oup.com/ehjcvp/article/4/3/142/4858492
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http://dx.doi.org/10.1093/ehjcvp/pvy006DOI Listing
July 2018
5 Reads

Use of integrated clinical trial protocols - A survey in early medicines development
.

Int J Clin Pharmacol Ther 2018 May;56(5):205-211

Purpose: To collect information on the use of integrated protocols in early clinical medicines development.

Materials And Methods: The questionnaire was mailed in fall 2014 to members of human pharmacology societies in Europe for anonymous responses via the online tool SurveyMonkey®.

Results: 97 respondents reported on 164 integrated protocols overall. Read More

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http://dx.doi.org/10.5414/CP203206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914155PMC
May 2018
6 Reads

Intraperitoneal insulin therapy in patients with type 1 diabetes. Does it fit into the current therapeutic arsenal?

Endocrinol Diabetes Nutr 2018 03 9;65(3):182-184. Epub 2018 Feb 9.

Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.endinu.2018.01.001DOI Listing

Russian guidelines for the management of COPD: algorithm of pharmacologic treatment.

Int J Chron Obstruct Pulmon Dis 2018 8;13:183-187. Epub 2018 Jan 8.

Pneumology Department, University Hospital Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

The high prevalence of COPD together with its high level of misdiagnosis and late diagnosis dictate the necessity for the development and implementation of clinical practice guidelines (CPGs) in order to improve the management of this disease. High-quality, evidence-based international CPGs need to be adapted to the particular situation of each country or region. A new version of the Russian Respiratory Society guidelines released at the end of 2016 was based on the proposal by Global Initiative for Obstructive Lung Disease but adapted to the characteristics of the Russian health system and included an algorithm of pharmacologic treatment of COPD. Read More

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http://dx.doi.org/10.2147/COPD.S153770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764288PMC
September 2018
22 Reads

The Impact of Underpowered Studies on Clinical Trial Results.

Am J Psychiatry 2018 02;175(2):188

From the Northwest Clinical Research Center, Bellevue, Wash.; the Department of Psychiatry, Duke University School of Medicine, Durham, N.C.; and the Department of Psychiatry and Human Behavior, Brown University, Providence, R.I.

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2017.17
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http://dx.doi.org/10.1176/appi.ajp.2017.17091016DOI Listing
February 2018
5 Reads

TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol.

BMJ Open 2018 01 27;8(1):e019463. Epub 2018 Jan 27.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Background: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important.

Objective: The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS).

Study Design: A single-blind, multicentre, randomised clinical trial of 1400 patients after an ACS with 12 months follow-up. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829769PMC
January 2018
62 Reads

Using the Medical Research Council framework for development and evaluation of complex interventions in a low resource setting to develop a theory-based treatment support intervention delivered via SMS text message to improve blood pressure control.

BMC Health Serv Res 2018 01 23;18(1):33. Epub 2018 Jan 23.

Chronic Disease Initiative for Africa, Cape Town, South Africa.

Background: Several frameworks now exist to guide intervention development but there remains only limited evidence of their application to health interventions based around use of mobile phones or devices, particularly in a low-resource setting. We aimed to describe our experience of using the Medical Research Council (MRC) Framework on complex interventions to develop and evaluate an adherence support intervention for high blood pressure delivered by SMS text message. We further aimed to describe the developed intervention in line with reporting guidelines for a structured and systematic description. Read More

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https://bmchealthservres.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12913-017-2808-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782371PMC
January 2018
3 Reads

The low indexes of metabolism intervention trial (LIMIT): design and baseline data of a randomized controlled clinical trial to evaluate how alerting primary care teams to low metabolic values, could affect the health of patients aged 75 or older.

BMC Health Serv Res 2018 01 5;18(1). Epub 2018 Jan 5.

The Department of Family Medicine, Azrieli Faculty of Medicine, Bar-Ilan University, Safed; The Department of Family Medicine, Clalit Health Services, North district, Israel.

Background: Too-low body mass index (BMI), HbA1c% or cholesterol levels predicts poor survival. This study investigates whether e-mails about these low values, improve health of people older than 75 years.

Methods: LIMIT - an open label randomized trial - compares usual care to the addition of an e-mail which alerts the family physicians and nurses to low metabolic indexes of a specific patient and advises on nutritional and medical changes. Read More

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https://bmchealthservres.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12913-017-2812-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755463PMC
January 2018
3 Reads

One-Year Effectiveness Study of Intravitreous Ranibizumab in Wet (Neovascular) Age-Related Macular Degeneration: A Meta-Analysis.

Pharmacotherapy 2018 02;38(2):197-204

Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose: The clinical efficacy of ranibizumab has been examined by a large number of prospective and retrospective studies to date. This meta-analysis was conducted to summarize the current body of evidence on visual acuity (VA) changes with use of ranibizumab in the treatment of wet (neovascular) age-related macular degeneration (wAMD).

Methods: A literature review of multiple electronic databases (EMBASE, MEDLINE, MedMEME) was conducted to find randomized controlled trials (RCTs) and observational studies that reported changes in VA while patients with wAMD were on ranibizumab. Read More

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http://doi.wiley.com/10.1002/phar.2079
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http://dx.doi.org/10.1002/phar.2079DOI Listing
February 2018
13 Reads

Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes.

BMJ Open 2017 12 21;7(12):e018302. Epub 2017 Dec 21.

China Oxford Centre for International Health Research, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Mobile health interventions have the potential to promote risk factor management and lifestyle modification, and are a particularly attractive approach for scaling across healthcare systems with limited resources. We are conducting two randomised trials to evaluate the efficacy of text message-based health messages in improving secondary coronary heart disease (CHD) prevention among patients with or without diabetes.

Methods And Analysis: The Cardiovascular Health And Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study are multicentre, single-blind, randomised controlled trials of text messaging versus standard treatment with 6 months of follow-up conducted in 37 hospitals throughout 17 provinces in China. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-01830
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http://dx.doi.org/10.1136/bmjopen-2017-018302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778311PMC
December 2017
27 Reads

The development of activatable lytic peptides for targeting triple negative breast cancer.

Cell Death Discov 2017 17;3:17037. Epub 2017 Jul 17.

Department of Chemical Biology, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, China.

Cytolytic peptides are an emerging class of promising cancer therapeutics shown to overcome drug resistance. They eliminate cancer cells via disruption of the phospholipid bilayer of cell membranes, a mechanism that differentiates it from traditional treatments. However, applications of lytic peptides via systematic administration are hampered by nonspecific toxicity. Read More

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http://dx.doi.org/10.1038/cddiscovery.2017.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629628PMC
July 2017
4 Reads