3,720 results match your criteria Letters in Drug Design & Discovery[Journal]


Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and Systemic Serious Adverse Events.

Ophthalmol Retina 2018 Feb;2(2):118-127

Centre for Experimental Medicine, Queen's University, Belfast, United Kingdom.

Purpose: To describe serum vascular endothelial growth factor (sVEGF) in patients with neovascular age-related macular degeneration (nAMD) receiving anti-VEGF agents and associations between sVEGF and systemic serious adverse events (SSAEs).

Design: Exploratory analyses of a randomized controlled trial that enrolled 610 participants with nAMD and compared 2 anti-VEGF antibodies, ranibizumab and bevacizumab, and 2 treatment regimens, monthly vs. discontinuous, with 2 years' follow-up. Read More

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http://dx.doi.org/10.1016/j.oret.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278944PMC
February 2018

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

Ital J Pediatr 2018 Dec 4;44(1):146. Epub 2018 Dec 4.

Institute of Pediatrics, University of Palermo, Palermo, Italy.

Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy, CNR (National Research Council) underlined how over 17 million, 42.8% of the population aged 15-64 have a gambling behavior. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0592-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280468PMC
December 2018
1 Read

The systematic case-referent method.

Therapie 2018 Oct 26. Epub 2018 Oct 26.

London School of Hygiene and Tropical Medicine, LA Risk Research, London EC1R 5BD, United Kingdom.

The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. Read More

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http://dx.doi.org/10.1016/j.therap.2018.09.073DOI Listing
October 2018
4 Reads

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency.

Trials 2018 Nov 20;19(1):642. Epub 2018 Nov 20.

Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

Background: In recent years, experience on the application of adaptive designs in confirmatory clinical trials has accumulated. Although planning such trials comes at the cost of additional operational complexity, adaptive designs offer the benefit of flexibility to update trial design and objectives as data accrue. In 2007, the European Medicines Agency (EMA) provided guidance on confirmatory clinical trials with adaptive (or flexible) designs. Read More

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http://dx.doi.org/10.1186/s13063-018-3012-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245528PMC
November 2018
6 Reads

Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer.

Mol Cancer 2018 Oct 31;17(1):156. Epub 2018 Oct 31.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression. One such possible new target is YWHAZ of the 14-3-3 protein family as this gene has prognostic significance for metastatic CRPC patients. However, there are no small molecules targeting YWHAZ commercially available. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0905-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208026PMC
October 2018
1 Read

Comparative, cross-sectional study of the format, content and timing of medication safety letters issued in Canada, the USA and the UK.

BMJ Open 2018 Oct 8;8(10):e020150. Epub 2018 Oct 8.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

Objectives: To assess consistency in the format and content, and overlap of subject and timing, of medication safety letters issued by regulatory health authorities to healthcare providers in Canada, the USA and the UK.

Design: A cross-sectional study comparing medication safety letters issued for the purpose of alerting healthcare providers to newly identified medication problems associated with medications already on the market.

Setting: Online databases operated by Health Canada, the US Food and Drug Administration and the UK Medicines and Healthcare products Regulatory Agency were searched to select medication safety letters issued between 1 January 2010 and 31 December 2014. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-02015
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http://dx.doi.org/10.1136/bmjopen-2017-020150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194396PMC
October 2018
1 Read

Fresh thoughts and perspectives on CARES study from viewpoint of an Asian physician: comment on the article by Choi et al.

Arthritis Rheumatol 2018 Oct 8. Epub 2018 Oct 8.

Institute of Metabolic Diseases, Qingdao University, Qingdao, China.

Following the report of CARES study published on NEJM and associated U.S. FDA's safety alert concerning febuxostat for management of hyperuricemia in gout, Choi et al. Read More

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http://doi.wiley.com/10.1002/art.40741
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http://dx.doi.org/10.1002/art.40741DOI Listing
October 2018
6 Reads

Magneto low-density nanoemulsion (MLDE): A potential vehicle for combined hyperthermia and photodynamic therapy to treat cancer selectively.

Mater Sci Eng C Mater Biol Appl 2018 Nov 20;92:103-111. Epub 2018 Jun 20.

Department of Chemistry, Center of Nanotechnologyand Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Brazil. Electronic address:

In this paper, we introduce a new drug delivery system (DDS) called magneto low-density nanoemulsion (MLDE), which can carry maghemite nanoparticles and Chlorin e6 as an active photosensitizer drug. This design can enhance tumor damage after minor heat dissipation and/or minimum visible light photosensitization doses by classical magnetic hyperthermia (MHT) and photodynamic therapy (PDT), respectively. We establish protocols to prepare the MLDE and to load the drug combination onto it. Read More

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http://dx.doi.org/10.1016/j.msec.2018.06.033DOI Listing
November 2018

Conbercept for Treatment of Neovascular Age-related Macular Degeneration: Results of the Randomized Phase 3 PHOENIX Study.

Am J Ophthalmol 2019 Jan 24;197:156-167. Epub 2018 Aug 24.

Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. Electronic address:

Purpose: Age-related macular degeneration (AMD) can cause irreversible vision loss leading to blindness. We aim to evaluate the efficacy and safety of intravitreal injections of 0.5 mg conbercept, a new anti-vascular endothelial growth factor (anti-VEGF) drug, for treatment of AMD on a schedule more manageable for patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183047
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http://dx.doi.org/10.1016/j.ajo.2018.08.026DOI Listing
January 2019
9 Reads

Design and synthesis of 5-(5-nitrothiophen-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazole derivatives with improved solubility and potential antituberculosis activity.

Chem Biol Drug Des 2018 Aug 24. Epub 2018 Aug 24.

Tuberculosis Immunology and Immunoassay Development Section, Radiation Medicine Centre-BARC, Tata Memorial Hospital, Mumbai, India.

We report the design-synthesis of several nitrothiophene containing molecules as antituberculosis agents. The molecules were designed on the basis of previously reported nitrofuran molecules in our laboratory, and the α,β-unsaturated linker was modified to cyclized linker in order to overcome the challenge of low solubility and possible toxicity. The stereo-electronic properties such as HOMO, LUMO, and HOMO-LUMO gap along with other properties such as aqueous solvation energies and QPLogS values were studied. Read More

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http://dx.doi.org/10.1111/cbdd.13386DOI Listing
August 2018
1 Read

Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema in a Real-World Clinical Setting.

Am J Ophthalmol 2018 Nov 9;195:209-222. Epub 2018 Aug 9.

Sacro Cuore Don Calabria Hospital, Verona, Italy.

Purpose: To report the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) in a real-world clinical setting and to assess the efficacy of subsequent alternative treatments in eyes with suboptimal response to anti-VEGF.

Design: Retrospective interventional case series.

Methods: The medical records of consecutive eyes with center-involving DME, treated between August 2008 and June 2015 with 3 monthly intravitreal anti-VEGF injections-with or without prompt or deferred laser-followed by pro re nata re-treatment, were reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183044
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http://dx.doi.org/10.1016/j.ajo.2018.08.004DOI Listing
November 2018
9 Reads

Early Response to Anti-Vascular Endothelial Growth Factor and Two-Year Outcomes Among Eyes With Diabetic Macular Edema in Protocol T.

Am J Ophthalmol 2018 Nov 2;195:93-100. Epub 2018 Aug 2.

Palmetto Retina Center, Columbia, South Carolina, USA.

Purpose: Assess associations of 2-year visual acuity (VA) outcomes with VA and optical coherence tomography central subfield thickness (CST) after 12 weeks of anti-vascular endothelial growth factor treatment for diabetic macular edema in DRCR.net Protocol T.

Design: Randomized clinical trial. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.07.030DOI Listing
November 2018
2 Reads
3.871 Impact Factor

The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials.

Clin Pharmacol Ther 2018 Nov 14;104(5):797. Epub 2018 Jul 14.

Certara QSP, Canterbury Innovation Centre, Canterbury, UK.

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http://dx.doi.org/10.1002/cpt.1145DOI Listing
November 2018

Getting personal with the "reproducibility crisis": interviews in the animal research community.

Lab Anim (NY) 2018 07;47(7):175-177

Tempest Technologies, Los Angeles, California, United States.

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http://dx.doi.org/10.1038/s41684-018-0088-6DOI Listing
July 2018
1 Read

Pragmatic randomised clinical trials using electronic health records: general practitioner views on a model of a priori consent.

Trials 2018 May 16;19(1):278. Epub 2018 May 16.

Medical Research Institute of New Zealand, Private Bag 7902, Wellington, 6242, New Zealand.

Pragmatic randomised clinical trials could use existing electronic health records (EHRs) to identify trial participants, perform randomisation, and to collect follow-up data. Achieving adequate informed consent in routine care and clinician recruitment have been identified as key barriers to this approach to clinical trials. We propose a model where written informed consent for a pragmatic comparative effectiveness trial is obtained in advance by the research team, recorded in the EHR, and then confirmed by the general practitioner (GP) at the time of enrolment. Read More

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http://dx.doi.org/10.1186/s13063-018-2658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956547PMC
May 2018
1 Read

Individual Negative Affective Trajectories Can Be Detected during Different Depressive Relapse Prevention Strategies.

Psychother Psychosom 2018 14;87(4):243-245. Epub 2018 May 14.

Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1159/000489044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159830PMC
November 2018
1 Read

Evaluation of aluminum phthalocyanine chloride and DNA interactions for the design of an advanced drug delivery system in photodynamic therapy.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Aug 5;201:242-248. Epub 2018 May 5.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Av. dos Bandeirantes 3900, 14040-901, Vila Monte Alegre, University of São Paulo, Brazil. Electronic address:

The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. Read More

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http://dx.doi.org/10.1016/j.saa.2018.05.009DOI Listing
August 2018
1 Read

Optimization of Human Semen Extender Components for Cryopreservation Using Statistical Tools.

Cryo Letters 2017 Nov/Dec;38(6):434-444

School of Biosciences and Technology, VIT University, Near Katpadi Road, Vellore, Tamil Nadu, India.

  BACKGROUND: Human sperm cell preservation is an important part of assisted reproductive technology (ART).

Objective: This study aimed to find the essential and significant components in semen preservation extender required to prolong the shelf life of human spermatozoa.

Materials And Methods: By using the statistical tool 'Plackett-Burman design' the significant components present in E4 extender (formulated in our previous study) was determined by reducing the unacceptable large number of trial experiments from the full factorial method. Read More

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Canonical correlation analysis to identify the semen characteristics used to forecast the freeze survival of Curimba (Prochilodus lineatus) spermatozoa.

Cryo Letters 2017 Jul/Aug;38(4):263-268

Departament of Animal Production, School of Veterinary and Zootechny, Federal University of Goias, Brazil.

  OBJECTIVE: To identify which sperm characteristics were able to predict more accurately the quality of curimba (Prochilodus lineatus) semen upon freezing using canonical correlation analysis.

Methods: Eleven fish breeders with initial mean weight of 705.21 ± 111 g were used. Read More

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A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.

FEBS Lett 2018 Jun 22;592(11):1837-1846. Epub 2018 May 22.

School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, China.

Uridine diphosphate-glucuronosyltransferases (UGTs) are the most important phase II enzymes in human drug metabolism. Using permeabilized recombinant fission yeast cells (enzyme bags), we demonstrate that UGT1A5 can catalyze an N-glucuronidation reaction. We characterized two new polymorphic UGT1A5 variants: a common ninefold mutant (UGT1A5*8) with double-fold activity and a much rarer sixfold mutant (UGT1A5*9), which has the same activity as the wild-type. Read More

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http://doi.wiley.com/10.1002/1873-3468.13072
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http://dx.doi.org/10.1002/1873-3468.13072DOI Listing
June 2018
5 Reads

Layer-by-layer hollow photosensitizer microcapsule design via a manganese carbonate hard template for photodynamic therapy in cells.

Photodiagnosis Photodyn Ther 2018 Jun 20;22:169-177. Epub 2018 Apr 20.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Av. dos Bandeirantes 3900, 14040-901, Vila Monte Alegre, University of São Paulo, Brazil. Electronic address:

Background: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.04.011DOI Listing
June 2018
2 Reads

Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema.

Cochrane Database Syst Rev 2018 04 18;4:CD011599. Epub 2018 Apr 18.

Royal Free London NHS Foundation Trust, London, UK.

Background: The combination of steroid and anti-vascular endothelial growth factor (VEGF) intravitreal therapeutic agents could potentially have synergistic effects for treating diabetic macular oedema (DMO). On the one hand, if combined treatment is more effective than monotherapy, there would be significant implications for improving patient outcomes. Conversely, if there is no added benefit of combination therapy, then people could be potentially exposed to unnecessary local or systemic side effects. Read More

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http://dx.doi.org/10.1002/14651858.CD011599.pub2DOI Listing
April 2018
10 Reads

Bioresorbable polymer drug-eluting stents.

Lancet 2018 03;391(10124):936

Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183053
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http://dx.doi.org/10.1016/S0140-6736(18)30532-4DOI Listing
March 2018
1 Read

Bioresorbable polymer drug-eluting stents - Authors' reply.

Lancet 2018 03;391(10124):936-937

Division of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, DC, USA.

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http://dx.doi.org/10.1016/S0140-6736(18)30535-XDOI Listing
March 2018
1 Read

Bioresorbable polymer drug-eluting stents.

Authors:
Rahman Shah

Lancet 2018 03;391(10124):935-936

University of Tennessee, School of Medicine, Section of Cardiovascular Medicine, Veterans Affairs Medical Center, Memphis, TN 38104, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)30528-2DOI Listing

Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.

FEBS Lett 2018 Apr 11;592(8):1445-1457. Epub 2018 Apr 11.

School of Stomatology and Medicine, Foshan University, China.

Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T- and B cells conserved across mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG_0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. Read More

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http://dx.doi.org/10.1002/1873-3468.13024DOI Listing
April 2018
9 Reads

Impact of post-dilatation on strut apposition of second-generation bioresorbable vascular scaffolds: Key role for scaffold thrombosis and prognosis?

Cardiol J 2018 ;25(1):148-150

Medical University of Gdansk, Gdansk, Poland University Hospital of Zurich, Zurich, Switzerland Institute for Cardiovascular Translational Research of the Atlantic, Spain.

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http://dx.doi.org/10.5603/CJ.2018.0013DOI Listing
November 2018
1 Read

Hospitalization Drug Regimen Changes in Geriatric Patients and Adherence to Modifications by General Practitioners in Primary Care.

J Nutr Health Aging 2018 ;22(3):328-334

Laure Rouch,Toulouse University Hospital, Department of Pharmacy, France,

Objectives: To evaluate the overall rate of adherence by general practitioners (GPs) to treatment modifications suggested at discharge from hospital and to assess the way communication between secondary and primary care could be improved.

Design: Observational prospective cohort study.

Setting: Patients hospitalized from the emergency department to the acute geriatric care unit of a university hospital. Read More

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http://dx.doi.org/10.1007/s12603-017-0940-1DOI Listing
January 2018
2 Reads

Potential link between sporadic cerebral amyloid angiopathy and vision loss: a case report.

Acta Ophthalmol 2018 Sep 20;96(6):e753-e755. Epub 2018 Feb 20.

Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.

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http://dx.doi.org/10.1111/aos.13681DOI Listing
September 2018
1 Read

Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.

ACS Comb Sci 2018 04 26;20(4):192-196. Epub 2018 Feb 26.

University of Groningen , Department of Drug Design , A. Deusinglaan 1 , 9713 AV Groningen , The Netherlands.

The synthesis of uracil/thymine containing tetra/trisubstituted imidazole derivatives was demonstrated using Ugi/Passerini-reaction followed by a postcyclization reaction sequence. The approach enables the one-pot facile construction of diverse compounds in moderate to excellent yields (47-82%). The 5-fluorouracil and 5-methyluracil moieties afford potentially bioactive molecules with drug-like properties. Read More

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http://dx.doi.org/10.1021/acscombsci.7b00145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894062PMC
April 2018
6 Reads

Use of integrated clinical trial protocols - A survey in early medicines development
.

Int J Clin Pharmacol Ther 2018 May;56(5):205-211

Purpose: To collect information on the use of integrated protocols in early clinical medicines development.

Materials And Methods: The questionnaire was mailed in fall 2014 to members of human pharmacology societies in Europe for anonymous responses via the online tool SurveyMonkey®.

Results: 97 respondents reported on 164 integrated protocols overall. Read More

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http://dx.doi.org/10.5414/CP203206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914155PMC
May 2018
5 Reads

Intraperitoneal insulin therapy in patients with type 1 diabetes. Does it fit into the current therapeutic arsenal?

Endocrinol Diabetes Nutr 2018 03 9;65(3):182-184. Epub 2018 Feb 9.

Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.endinu.2018.01.001DOI Listing

Russian guidelines for the management of COPD: algorithm of pharmacologic treatment.

Int J Chron Obstruct Pulmon Dis 2018 8;13:183-187. Epub 2018 Jan 8.

Pneumology Department, University Hospital Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

The high prevalence of COPD together with its high level of misdiagnosis and late diagnosis dictate the necessity for the development and implementation of clinical practice guidelines (CPGs) in order to improve the management of this disease. High-quality, evidence-based international CPGs need to be adapted to the particular situation of each country or region. A new version of the Russian Respiratory Society guidelines released at the end of 2016 was based on the proposal by Global Initiative for Obstructive Lung Disease but adapted to the characteristics of the Russian health system and included an algorithm of pharmacologic treatment of COPD. Read More

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http://dx.doi.org/10.2147/COPD.S153770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764288PMC
September 2018
21 Reads

The Impact of Underpowered Studies on Clinical Trial Results.

Am J Psychiatry 2018 02;175(2):188

From the Northwest Clinical Research Center, Bellevue, Wash.; the Department of Psychiatry, Duke University School of Medicine, Durham, N.C.; and the Department of Psychiatry and Human Behavior, Brown University, Providence, R.I.

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http://dx.doi.org/10.1176/appi.ajp.2017.17091016DOI Listing
February 2018

TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol.

BMJ Open 2018 01 27;8(1):e019463. Epub 2018 Jan 27.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Background: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important.

Objective: The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS).

Study Design: A single-blind, multicentre, randomised clinical trial of 1400 patients after an ACS with 12 months follow-up. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829769PMC
January 2018
40 Reads

Using the Medical Research Council framework for development and evaluation of complex interventions in a low resource setting to develop a theory-based treatment support intervention delivered via SMS text message to improve blood pressure control.

BMC Health Serv Res 2018 01 23;18(1):33. Epub 2018 Jan 23.

Chronic Disease Initiative for Africa, Cape Town, South Africa.

Background: Several frameworks now exist to guide intervention development but there remains only limited evidence of their application to health interventions based around use of mobile phones or devices, particularly in a low-resource setting. We aimed to describe our experience of using the Medical Research Council (MRC) Framework on complex interventions to develop and evaluate an adherence support intervention for high blood pressure delivered by SMS text message. We further aimed to describe the developed intervention in line with reporting guidelines for a structured and systematic description. Read More

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http://dx.doi.org/10.1186/s12913-017-2808-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782371PMC
January 2018
2 Reads

The low indexes of metabolism intervention trial (LIMIT): design and baseline data of a randomized controlled clinical trial to evaluate how alerting primary care teams to low metabolic values, could affect the health of patients aged 75 or older.

BMC Health Serv Res 2018 01 5;18(1). Epub 2018 Jan 5.

The Department of Family Medicine, Azrieli Faculty of Medicine, Bar-Ilan University, Safed; The Department of Family Medicine, Clalit Health Services, North district, Israel.

Background: Too-low body mass index (BMI), HbA1c% or cholesterol levels predicts poor survival. This study investigates whether e-mails about these low values, improve health of people older than 75 years.

Methods: LIMIT - an open label randomized trial - compares usual care to the addition of an e-mail which alerts the family physicians and nurses to low metabolic indexes of a specific patient and advises on nutritional and medical changes. Read More

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https://bmchealthservres.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12913-017-2812-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755463PMC
January 2018
3 Reads

Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes.

BMJ Open 2017 12 21;7(12):e018302. Epub 2017 Dec 21.

China Oxford Centre for International Health Research, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Mobile health interventions have the potential to promote risk factor management and lifestyle modification, and are a particularly attractive approach for scaling across healthcare systems with limited resources. We are conducting two randomised trials to evaluate the efficacy of text message-based health messages in improving secondary coronary heart disease (CHD) prevention among patients with or without diabetes.

Methods And Analysis: The Cardiovascular Health And Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study are multicentre, single-blind, randomised controlled trials of text messaging versus standard treatment with 6 months of follow-up conducted in 37 hospitals throughout 17 provinces in China. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-01830
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http://dx.doi.org/10.1136/bmjopen-2017-018302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778311PMC
December 2017
21 Reads

The development of activatable lytic peptides for targeting triple negative breast cancer.

Cell Death Discov 2017 17;3:17037. Epub 2017 Jul 17.

Department of Chemical Biology, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, China.

Cytolytic peptides are an emerging class of promising cancer therapeutics shown to overcome drug resistance. They eliminate cancer cells via disruption of the phospholipid bilayer of cell membranes, a mechanism that differentiates it from traditional treatments. However, applications of lytic peptides via systematic administration are hampered by nonspecific toxicity. Read More

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http://dx.doi.org/10.1038/cddiscovery.2017.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629628PMC
July 2017
1 Read

Housing and overdose: an opportunity for the scale-up of overdose prevention interventions?

Harm Reduct J 2017 Dec 6;14(1):77. Epub 2017 Dec 6.

British Columbia Centre on Substance Use, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Background: North America is currently experiencing an overdose epidemic due to a significant increase of fentanyl-adulterated opioids and related analogs. Multiple jurisdictions have declared a public health emergency given the increasing number of overdose deaths. In the province of British Columbia (BC) in Canada, people who use drugs and who are unstably housed are disproportionately affected by a rising overdose crisis, with close to 90% of overdose deaths occurring indoors. Read More

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http://dx.doi.org/10.1186/s12954-017-0203-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719740PMC
December 2017
2 Reads

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.

Clin Epigenetics 2017 28;9:123. Epub 2017 Nov 28.

Pathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck and the Research Center Borstel Parkallee 3, 23845 Borstel, Germany.

Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Read More

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-017-0423-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704452PMC
July 2018
13 Reads

The VEGF Treatment of AMD Switch Study (The vTAS Study).

Asia Pac J Ophthalmol (Phila) 2017 Nov-Dec;6(6):481-487

Hobart Eye Surgeons, Hobart, Australia.

Purpose: To evaluate the effect of aflibercept on anatomic and visual outcomes in patients with choroidal neovascularization (CNV) previously treated with intravitreal ranibizumab with persistent fluid on optical coherence tomography (OCT).

Design: Prospective, open-label study.

Methods: Eighteen patients (19 eyes) with CNV being treated with monthly ranibizumab, with persistent fluid on OCT, were switched to intravitreal aflibercept injections at intervals of up to 8 weeks. Read More

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http://dx.doi.org/10.22608/APO.2017364DOI Listing
December 2017
1 Read

Characteristics of NPS use in patients admitted to acute psychiatric services in Southeast Scotland: a retrospective cross-sectional analysis following public health interventions.

BMJ Open 2017 Dec 3;7(12):e015716. Epub 2017 Dec 3.

Department of Psychiatry, University of Edinburgh, Edinburgh, UK.

Objectives: Assess the impact of selective prohibition and seizure of novel psychoactive substances (NPS) supply on NPS use prevalence within psychiatric admissions and evaluate demographic characteristics of current NPS users.

Design: A 6-month retrospective cross-sectional analysis of discharge letters between 1 October 2015 and 31 March 2016.

Setting: General psychiatry inpatients and intensive home treatment team (IHTT) community patients at a psychiatric hospital in a Scottish city. Read More

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http://dx.doi.org/10.1136/bmjopen-2016-015716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778313PMC
December 2017
1 Read

Utilization of the Bologna criteria: a promise unfulfilled? A review of published and unpublished/ongoing trials.

Fertil Steril 2018 01 29;109(1):104-109.e2. Epub 2017 Nov 29.

Women's Health Center Assisted Reproduction Unit, American Hospital, Istanbul, Turkey; Department of Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey.

Objective: To study the use of the Bologna criteria (BC) for the definition of poor ovarian responders (POR) in clinical practice and research.

Design: Systematic review of published and unpublished/ongoing trials between January 2012 and August 2017 on POR.

Setting: Not applicable. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2017.09.024DOI Listing
January 2018
1 Read

Design, synthesis, and cytotoxic evaluation of novel furo[2,3-b]quinoline derivatives.

Chem Biol Drug Des 2018 Apr 20;91(4):957-961. Epub 2018 Jan 20.

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.

A number of novel furo[2,3-b]quinoline derivatives were designed and synthesized by introducing benzyl ether, benzoate, and benzenesulfonate to 6-position of furo[2,3-b]quinoline and their chemical structures were confirmed by ESI-MS, H NMR, and C NMR spectra. All target compounds were evaluated in vitro against four human cancer cell lines (HCT-116, MCF-7, U2OS, and A549) by MTT method. Cytotoxic assay showed that compounds 8a, 8e, 10a, 10b, and 10c exhibited more potent cytotoxicities compared to 2-bromine-6-hydroxy-furo-[2,3-b]quinoline (7). Read More

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http://dx.doi.org/10.1111/cbdd.13154DOI Listing
April 2018
2 Reads

Self-administered Versus Directly Observed Once-Weekly Isoniazid and Rifapentine Treatment of Latent Tuberculosis Infection: A Randomized Trial.

Ann Intern Med 2017 Nov 7;167(10):689-697. Epub 2017 Nov 7.

From Denver Health and Hospital Authority and the University of Colorado Health Sciences Center, Denver, Colorado; Emory University and Fulton County Department of Health and Wellness, Atlanta, Georgia; Centers for Disease Control and Prevention, Atlanta, Georgia; Public Health Agency of Barcelona and CIBER de Epidemiología y Salud Pública, Barcelona, Spain; University of the Witwatersrand, Johannesburg, South Africa; Vanderbilt University, Nashville, Tennessee; Westat, Fort Lauderdale, Florida; University of Barcelona, Barcelona, Spain; and University of Texas Health Science Center and Veterans Administration Medical Center, San Antonio, Texas.

Background: Expanding latent tuberculosis treatment is important to decrease active disease globally. Once-weekly isoniazid and rifapentine for 12 doses is effective but limited by requiring direct observation.

Objective: To compare treatment completion and safety of once-weekly isoniazid and rifapentine by self-administration versus direct observation. Read More

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http://annals.org/article.aspx?doi=10.7326/M17-1150
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http://dx.doi.org/10.7326/M17-1150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766341PMC
November 2017
16 Reads

Do digital innovations for HIV and sexually transmitted infections work? Results from a systematic review (1996-2017).

BMJ Open 2017 Nov 3;7(11):e017604. Epub 2017 Nov 3.

Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, Canada.

Objective: Digital innovations with internet/mobile phones offer a potential cost-saving solution for overburdened health systems with high service delivery costs to improve efficiency of HIV/STI (sexually transmitted infections) control initiatives. However, their overall evidence has not yet been appraised. We evaluated the feasibility and impact of all digital innovations for all HIV/STIs. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-017604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695353PMC
November 2017
24 Reads

Design, synthesis, and cytotoxic evaluation of novel scopoletin derivatives.

Chem Biol Drug Des 2018 Feb 9;91(2):641-646. Epub 2017 Nov 9.

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.

A series of scopoletin derivatives were designed and synthesized by introducing α-aminoacetamide, acrylamide and β-aminopropamide, respectively, to 3-position of scopoletin, and their chemical structures were confirmed by ESI-MS, IR, H NMR, and C NMR spectra. All target compounds were evaluated in vitro against four human cancer cell lines (MDA-MB-231, MCF-7, HepG2, and A549) by MTT method. Cytotoxic assay showed that compounds 7a, 7b, 7e, 7f, 8a, and 8e exhibited more potent cytotoxicities compared to scopoletin. Read More

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http://dx.doi.org/10.1111/cbdd.13120DOI Listing
February 2018
3 Reads

Quantifying the importance of inhaler attributes corresponding to items in the patient satisfaction and preference questionnaire in patients using Combivent Respimat.

Health Qual Life Outcomes 2017 Oct 16;15(1):201. Epub 2017 Oct 16.

RTI Health Solutions, 3040 Cornwallis Road, Post Office Box 12194, Research Triangle Park, Durham, NC, 27709-2194, UK.

Background: Physicians consider ease of use, satisfaction, and preferences when prescribing an inhaler device. These factors may impact appropriate usage and compliance.

Methods: The objectives were to quantify the relative importance of inhaler attributes in patients currently using Combivent Respimat by eliciting preferences for performance and convenience attributes assessed by items in the Patient Satisfaction and Preference Questionnaire (PASAPQ). Read More

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http://hqlo.biomedcentral.com/articles/10.1186/s12955-017-07
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http://dx.doi.org/10.1186/s12955-017-0780-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644105PMC
October 2017
18 Reads