26,718 results match your criteria Les Cahiers da€™Ophtalmologie [Journal]


Minimum Information about an Uncultivated Virus Genome (MIUViG).

Nat Biotechnol 2018 Dec 17. Epub 2018 Dec 17.

US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. Read More

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http://www.nature.com/doifinder/10.1038/nbt.4306
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http://dx.doi.org/10.1038/nbt.4306DOI Listing
December 2018
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Sex selection in late Iberian infant burials: Integrating evidence from morphological and genetic data.

Am J Hum Biol 2018 Dec 16:e23204. Epub 2018 Dec 16.

Unitat d'Antropologia biològica, Departament de Biologia Animal, de Biologia Vegetal i Ecologia, Facultat Biociències, Universitat Autònoma de Barcelona, Bellaterra-Cerdanyola del Vallès, Spain.

Objective: The aim of this study was to analyze the infant burials found inside Iberian homes in relation to a possible case of sex selection.

Methods: The study included the remains of 11 infant individuals buried under the 10 houses excavated in the late Iberian village of Camp de les Lloses (Tona, Barcelona, Spain). Sex was determined using genetic analysis. Read More

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http://dx.doi.org/10.1002/ajhb.23204DOI Listing
December 2018

Sex-Related Differences in Lactotroph Tumor Aggressiveness Are Associated With a Specific Gene-Expression Signature and Genome Instability.

Front Endocrinol (Lausanne) 2018 30;9:706. Epub 2018 Nov 30.

Centre de Recherche en Cancérologie de Lyon (CRCL), INSERM U1052, CNRS UMR5286, Université de Lyon, Lyon, France.

Sex-related differences have been reported in various cancers, in particular men with lactotroph tumors have a worse prognosis than women. While the underlying mechanism of this sexual dimorphism remains unclear, it has been suggested that a lower estrogen receptor alpha expression may drive the sex differences observed in aggressive and malignant lactotroph tumors that are resistant to dopamine agonists. Based on this observation, we aimed to explore the molecular importance of the estrogen pathway through a detailed analysis of the transcriptomic profile of lactotroph tumors from 20 men and 10 women. Read More

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http://dx.doi.org/10.3389/fendo.2018.00706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283894PMC
November 2018

Factors predictive of prognosis of infantile spasms. A retrospective study in a low-income country.

Arch Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, La Rabta Hospital, Jabbari, 1007 Tunis, Tunisia; Université Tunis El Manar, Faculté de Médecine de Tunis, 15, Rue Djebel Lakhdhar, 1007 La Rabta, Tunisia; LR12SPO2 les maladies héréditaires du métabolisme investigation et prise en charge, 1007 Tunis, Tunisia.

Purpose: To describe the management of infants with epileptic spasms (ESs) in a low-income country and identify factors predictive of their prognosis.

Material And Methods: We conducted a retrospective study in a university hospital in Tunis, Tunisia, over a period of 10 years. We included infants with recurrent ESs. Read More

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http://dx.doi.org/10.1016/j.arcped.2018.10.003DOI Listing
December 2018

Iterative cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: A multi-institutional experience.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

St. George Hospital & University of New South Wales, Department of Surgery, Sydney, NSW, Australia.

Background And Objectives: The aims of this multi-institutional study were to assess the feasibility of iterative cytoreductive surgery (iCRS)/hyperthermic intraperitoneal chemotherapy, iCRS in colorectal peritoneal carcinomatosis (CRPC), evaluate survival, recurrence, morbidity and mortality outcomes, and identify prognostic factors for overall survival.

Methods: Patients with CRPC that underwent an iCRS, with or without intraperitoneal chemotherapy, from June 1993 to July 2016 at 13 institutions were retrospectively analyzed from prospectively maintained databases.

Results: The study comprised of 231 patients, including 126 females (54. Read More

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http://dx.doi.org/10.1002/jso.25277DOI Listing
December 2018

Annual Injection of Zoledronic Acid Improves Bone Status in Children with Cerebral Palsy and Rett Syndrome.

Calcif Tissue Int 2018 Dec 15. Epub 2018 Dec 15.

Centre de référence des erreurs innées du métabolisme, Hôpital d'Enfants, CHRU Nancy, Nancy, France.

Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. Read More

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http://dx.doi.org/10.1007/s00223-018-0505-2DOI Listing
December 2018

Development of co-continuous morphology in blends of thermoplastic starch and low-density polyethylene.

Carbohydr Polym 2019 Feb 13;206:757-766. Epub 2018 Nov 13.

Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500 boulevard de l'Université, Sherbrooke, QC, Canada. Electronic address:

This study focuses on the morphology development in blends of thermoplastic starch (TPS) with Low Density Polyethylene (LDPE) in the 40 to 80 TPS wt% concentration range. The effect of glycerol and water content on TPS rheology and the subsequent morphology development after blending with LDPE of various viscosity levels was investigated. The TPS/LDPE viscosity ratio was modified either by increasing the TPS plasticization or by proper selection of the LDPE grade. Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.11.038DOI Listing
February 2019

Simultaneous quantification of the degree of hydrolysis, protein conversion rate and mean molar weight of peptides released in the course of enzymatic proteolysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 6;1105:1-9. Epub 2018 Dec 6.

Laboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, LRGP, F-54000 Nancy, France; Université de Lorraine, 2 Avenue de la forêt de Haye, F-54505 Vandœuvre-lès-Nancy, France. Electronic address:

This paper describes an original analytical methodology for a simultaneous measurement of the protein conversion rate, the mean molar weight of peptide and the degree of hydrolysis in the course of proteolysis by Size-Exclusion High-Performance Liquid Chromatography. Peak area of dead volume eluents reflects the non-converted protein. The protein conversion rate is thus determined by comparing the area at a given time to the initial area. Read More

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http://dx.doi.org/10.1016/j.jchromb.2018.12.005DOI Listing
December 2018

Dual 0.02% chlorhexidine digluconate - 0.1% disodium EDTA loaded thermosensitive ocular gel for Acanthamoeba keratitis treatment.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Service Pharmaceutique, Plateforme Fripharm, Groupe Hospitalier Centre Edouard Herriot, Hospices Civils de Lyon, 5, Place d'Arsonval, F-69437 Lyon cedex 03, France; Université de Lyon, Laboratoire de Pharmacie Galénique Industrielle, UMR-CNRS 5305, Plateforme Fripharm, ISPB-Faculté de Pharmacie, Université Claude Bernard Lyon 1, 8, avenue Rockefeller, F-69373 Lyon Cedex 08, France. Electronic address: http://fripharm.com.

Poor bioavailability and low residence time limit the efficiency of conventional biguanide-based eye drops against Acanthamoeba keratitis. The aim of this work was to formulate an original anti-amoebic thermoreversible ocular gel combining biguanide and metalloproteases inhibitor - chelating agent. Chlorhexidine digluconate (CHX)-ethylenediaminetetraacetic acid disodium salt (NaEDTA) were compounded in poloxamer 407 saline solution. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.016DOI Listing
December 2018

Machine learning for predicting psychotic relapse at 2 years in schizophrenia in the national FACE-SZ cohort.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Fondation FondaMental, Créteil, France; Faculté de Médecine, Université d'Auvergne, CMP B, CHU, EA 7280, Clermont-Ferrand Cedex 69 63003, France.

Background: Predicting psychotic relapse is one of the major challenges in the daily care of schizophrenia.

Objectives: To determine the predictors of psychotic relapse and follow-up withdrawal in a non-selected national sample of stabilized community-dwelling SZ subjects with a machine learning approach.

Methods: Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical and cognitive assessment, including recording of current treatment. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2018.12.005DOI Listing
December 2018
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Management of invasive squamous cell carcinomas of the conjunctiva Treatment of invasive conjunctival carcinoma.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Purpose: Ocular Surface Squamous Neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.11.024DOI Listing
December 2018

Comparison of macronutrient content in human milk measured by mid-infrared human milk analyzer and reference methods.

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Nestlé Research, Vers-chez-les Blanc, P.O. Box 44, 1000, Lausanne 26, Switzerland.

Objective: The study aims at evaluating mid-infrared human milk analyzer (HMA) accuracy and precision, in human milk (HM).

Study Design: Röse-Gottlieb, high-performance anion exchange chromatography-pulsed amperometric detection (HPAEC-PAD), Kjeldahl and amino acid analysis (AA) were selected as references for total fat, lactose and total protein determination.

Results: No significant difference was observed in lactose content between HMA and HPAEC-PAD. Read More

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http://dx.doi.org/10.1038/s41372-018-0291-8DOI Listing
December 2018

[Which photon energy for intensity-modulated radiotherapy and volumetric-modulated arctherapy in 2019?]

Cancer Radiother 2018 Dec 11. Epub 2018 Dec 11.

Campus Sciences, centre de recherche en automatique de Nancy (Cran), BP 70239, 54506 Vandœuvre-lès-Nancy cedex, France; Campus Sciences, université de Lorraine, UMR 7039, BP 70239, 54506 Vandœuvre-lès-Nancy cedex, France; CNRS, UMR7039, Campus Sciences, BP 70239, 54506 Vandœuvre-lès-Nancy cedex, France.

For more than a decade, the majority of radiation oncology centres have been delivering intensity-modulated radiotherapy (then volumetric-modulated arctherapy) with 6 MV photons as their standard of care. This « dogma » had been supported by the usual absence of dosimetric advantages with high-energy photons (15 to 18 MV or more), at least for the planning target volume and the dose received by the adjacent organs at risk, and by the neutron component as soon as the photon energy exceeds 10 MV. Recent data could question such a dogma. Read More

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http://dx.doi.org/10.1016/j.canrad.2018.04.003DOI Listing
December 2018

[A place for intimacy and sexuality in nursing homes].

Soins 2018 Dec;63(831):48-51

c/o Soins, Elsevier Masson SAS, 65, rue Camille-Desmoulins, 92442 Issy-les-Moulineaux, France. Electronic address:

In nursing homes, intimacy is threatened by the increased dependence and lack of support. It is nevertheless possible to preserve it, meaning it is possible to ensure a continuity of existence for the elderly person in an institution. Read More

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http://dx.doi.org/10.1016/j.soin.2018.10.014DOI Listing
December 2018

Intimité, pudeur et respect des personnes.

Authors:
Florence Michon

Soins 2018 Dec;63(831):31-58

c/o Soins, Elsevier Masson SAS, 65, rue Camille-Desmoulins, 92442 Issy-les-Moulineaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.soin.2018.10.009DOI Listing
December 2018

Peut-on soigner une personne contre sa volonté ?

Authors:
Daniel Maroudy

Soins 2018 Dec;63(831)

c/o Soins, Elsevier Masson SAS, 65, rue Camille-Desmoulins, 92442 Issy-les-Moulineaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.soin.2018.10.019DOI Listing
December 2018

Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach.

Biomed Pharmacother 2019 Jan 5;109:1000-1007. Epub 2018 Nov 5.

Research Department, Innlandet Hospital Trust, Brumunddal, Norway; Inland Norway University of Applied Sciences, Elverum, Norway.

Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue and long-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease is difficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms. Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms, have recently been reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183429
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http://dx.doi.org/10.1016/j.biopha.2018.10.076DOI Listing
January 2019
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Translating preventive chemotherapy prevalence thresholds for Schistosoma mansoni from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006941. Epub 2018 Dec 14.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. The point-of-care circulating cathodic antigen (POC-CCA) is a promising rapid diagnostic test detecting antigen output of living worms in urine and results are reported as trace, 1+, 2+, and 3+. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006941
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http://dx.doi.org/10.1371/journal.pntd.0006941DOI Listing
December 2018
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Bone maturation of MRI residual developmental dysplasia of the hip with discrepancy between osseous and cartilaginous acetabular index.

J Pediatr Orthop B 2018 Dec 13. Epub 2018 Dec 13.

Departments of Paediatric Orthopaedic Surgery.

Quality of spontaneous amelioration of residual developmental dysplasia of the hip (DDH) is nowadays not possible to predict. Normal age-related values of the osseous acetabular index (OAI), cartilaginous acetabular index and labral acetabular index have been established on MRI. In this study, MRI of dysplastic hips has been evaluated, and further osseous acetabular maturation was followed-up over time on pelvic radiography to find a correlation between MRI findings and radiological evolution. Read More

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http://dx.doi.org/10.1097/BPB.0000000000000581DOI Listing
December 2018
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Screen time and moderate-to-vigorous physical activity changes and displacement in adolescence: A prospective cohort study.

Eur J Sport Sci 2018 Dec 14:1-10. Epub 2018 Dec 14.

a Departament de Didàctica de l'Expressió Musical, Plàstica i Corporal , Universitat de València , Valencia , Spain.

Background: This paper determines longitudinal changes in the time Spanish adolescents devote to moderate-to-vigorous physical activity (MVPA) and screen media activity (SMA). Moreover, it examines the displacement hypothesis between time spent on SMA and MVPA.

Methods: A cohort of 755 adolescents participated in a prospective cohort study over a three-year period. Read More

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http://dx.doi.org/10.1080/17461391.2018.1548649DOI Listing
December 2018

[Olecranon fractures].

Rev Med Suisse 2018 Dec;14(631):2264-2267

Service de chirurgie orthopédique et traumatologique, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

Olecranon fractures represent 5 % of all adult fractures. Management is most often surgical. Conservative treatment is recommended for non-displaced fractures or patients who would be poor surgical candidates. Read More

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December 2018
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[Cartilaginous tumours].

Rev Med Suisse 2018 Dec;14(631):2259-2263

Service d'orthopédie et traumatologie de l'appareil moteur, HUG, 1211 Genève 14.

Cartilaginous tumours are rare and often incidentally discovered on imaging. They can also be responsible for osteoarticular symptoms (pain, joint stiffness, deformity or fracture) and will require a clinical, radiological and a histopathological assessment. Depending on the lesion, the management may consist of observation or a complex surgical procedure that will take place after a multidisciplinary discussion including the radiologist, the pathologist and the orthopaedic surgeon. Read More

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December 2018

[Robotic surgery : the future of prosthetic surgery ?]

Rev Med Suisse 2018 Dec;14(631):2238-2242

Service d'orthopédie et traumatologie de l'appareil moteur, HUG, 1211 Genève 14.

Indications for hip and knee replacement will continue to grow over the next few years. Robotic systems have been developed since the early 1990s in order to optimize implant positioning, to potentially improve clinical results, and to reduce perioperative morbidity. Currently, the different available systems certainly improve the accuracy and reproducibility of prosthetic components placement. Read More

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December 2018

Quality control and stability of ketamine, remifentanil and sufentanil syringes in a pediatric operating theater.

Paediatr Anaesth 2018 Dec 14. Epub 2018 Dec 14.

CHU Lille, Institut de Pharmacie, F-59000, Lille, France.

Background: Transforming a drug from its commercial form into a ready-to-use drug is common practice, especially in pediatrics. However, the risk of compounding error is real and data on drug stability in practise are not always available.

Aims: To assess, in real conditions, both the error rate and stability of 3 drugs: ketamine, remifentanil and sufentanil. Read More

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http://dx.doi.org/10.1111/pan.13563DOI Listing
December 2018

A diversity of alkylation/acylation products of uracil and its derivatives: synthesis and a structural study.

Org Biomol Chem 2018 Dec 14. Epub 2018 Dec 14.

Pharmaceutical Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland. and University of Warsaw, Faculty of Chemistry, 1 Pasteura Str., 02-093 Warsaw, Poland.

tert-Butyl dicarbonate (Boc2O) and ethyl iodide (EtI) reactions with uracil (U), thymine (T) and 6-methyluracil (6-MU) were performed following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the molecular structure of all uracil derivatives. Read More

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http://dx.doi.org/10.1039/c8ob02552eDOI Listing
December 2018

Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.

BMC Infect Dis 2018 Dec 14;18(1):662. Epub 2018 Dec 14.

Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.

Background: Large scale administration of the anthelminthic drug praziquantel (PZQ) to at-risk populations is the cornerstone of schistosomiasis control, although persisting high prevalence of infections in some areas and growing concerns of PZQ resistance have revealed the limitations of this strategy. Most studies assessing PZQ efficacy have used relatively insensitive parasitological diagnostics, such as the Kato-Katz (KK) and urine-filtration methods, thereby overestimating cure rates (CRs). This study aims to determine the efficacy of repeated PZQ treatments against Schistosoma mansoni infection in school-aged children in Côte d'Ivoire using the traditional KK technique, as well as more sensitive antigen- and DNA-detection methods. Read More

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http://dx.doi.org/10.1186/s12879-018-3554-2DOI Listing
December 2018

Deprescribing conversations: a closer look at prescriber-patient communication.

Ther Adv Drug Saf 2018 Dec 20;9(12):687-698. Epub 2018 Oct 20.

Facultés de Médecine et de Pharmacie, Université de MontréalResearch Center of Institut Universitaire de Gériatrie de Montréal, Québec, Canada.

Background: Little is known about the initiation, style and content of patient and healthcare provider communication around deprescribing. We report the findings from a content analysis of audio-recorded discussions of proton pump inhibitor (PPI) and benzodiazepine deprescribing in primary care.

Methods: Participants were healthcare providers ( = 13) from primary care practices ( = 3) and patients aged ⩾65 ( = 24) who were chronic users of PPIs or benzodiazepines. Read More

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http://dx.doi.org/10.1177/2042098618804490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287327PMC
December 2018

Primary Anion-π Catalysis and Autocatalysis.

J Am Chem Soc 2018 Dec 13. Epub 2018 Dec 13.

Department of Organic Chemistry , University of Geneva , Geneva CH 1211 , Switzerland.

Epoxide-opening ether cyclizations are shown to occur on π-acidic aromatic surfaces without the need of additional activating groups and with autocatalytic amplification. Increasing activity with the intrinsic π acidity of benzenes, naphthalenediimides (NDIs) and perylenediimides (PDIs) support that anion-π interactions account for function. Rate enhancements maximize at 270 for anion-π catalysis on fullerenes and at 5100 M for autocatalysis. Read More

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http://dx.doi.org/10.1021/jacs.8b11788DOI Listing
December 2018

Design and implementation of the Competency Assessment Tool (CAT): user experience usability study.

Inform Health Soc Care 2018 Dec 13:1-20. Epub 2018 Dec 13.

c Centre d'excellence sur le vieillissement de Québec (CEVQ) , Université Laval , Québec , Canada.

The decision on patients' competency to manage their affairs and take care of themselves requires a rigorous evaluation process and consistency among practice settings. Research indicates there is a lack of resources to guide healthcare and social service professionals in the interprofessional decision-making process that such an evaluation requires. A web-based tool, the Competency Assessment Tool (CAT), was designed to assist professionals in that process. Read More

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http://dx.doi.org/10.1080/17538157.2018.1550414DOI Listing
December 2018

« Ce mot à ne pas prononcer »: Réagir au malaise des patients face au mot .

Authors:
Martin Fortin

Can Fam Physician 2018 Dec;64(12):e512-e513

Médecin de famille à l'Unité de médecine de famille de l'Hôpital de Chicoutimi et au Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-Saint-Jean, au Québec, professeur titulaire au Département de médecine de famille et de médecine d'urgence de l'Université de Sherbrooke, au Québec, et titulaire de la Chaire de recherche sur les maladies chroniques en soins de première ligne.

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December 2018

Bad metallic transport in a cold atom Fermi-Hubbard system.

Science 2018 Dec 6. Epub 2018 Dec 6.

Department of Physics, Princeton University, Princeton, NJ 08544, USA.

Strong interactions in many-body quantum systems complicate the interpretation of charge transport in such materials. To shed light on this problem, we study transport in a clean quantum system: ultracold Li in a two-dimensional (2D) optical lattice, a testing ground for strong interaction physics in the Fermi-Hubbard model. We determine the diffusion constant by measuring the relaxation of an imposed density modulation and modeling its decay hydrodynamically. Read More

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http://dx.doi.org/10.1126/science.aat4134DOI Listing
December 2018

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Universitätsmedizin Göttingen, Göttingen, Germany.

Background: Based on the encouraging activity and manageable safety profile observed in a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and safety of brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A+CHP) versus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for the treatment of CD30-positive peripheral T-cell lymphomas.

Methods: ECHELON-2 is a double-blind, double-dummy, randomised, placebo-controlled, active-comparator phase 3 study. Eligible adults from 132 sites in 17 countries with previously untreated CD30-positive peripheral T-cell lymphomas (targeting 75% with systemic anaplastic large cell lymphoma) were randomly assigned 1:1 to receive either A+CHP or CHOP for six or eight 21-day cycles. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32984-2DOI Listing
December 2018

Views on a new surgical assistance method for implanting the glenoid component during total shoulder arthroplasty. Part 2: From three-dimensional reconstruction to augmented reality: Feasibility study.

Orthop Traumatol Surg Res 2018 Dec 3. Epub 2018 Dec 3.

Service d'orthopédie traumatologie 1C, faculté de médecine de Tours, université François-Rabelais de Tours, CHRU Trousseau, avenue de la République, 37170 Chambray-lès-Tours, France; Société d'orthopédie de L'Ouest (SOO)/HUGORTHO, 18, rue de Bellinière, Trélazé, France.

Introduction: The main goal of this study was to propose a new method of surgical assistance for the implantation of a total shoulder prosthesis, with the use of augmented reality (AR). The advantage of this approach is that it supplements information, on the one hand pre-existing or disappeared due to a pathological process, such as the premorbid glenoid, and on the other hand already existing but not accessible to the surgeon during the procedure, such as the so-called "hidden" face of the scapula.

Material And Methods: Several information preparation steps were needed. Read More

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http://dx.doi.org/10.1016/j.otsr.2018.08.021DOI Listing
December 2018

1/6 Les mots de la gérontologie : d’abandon à atonie.

Authors:
Christian Moreau

Soins Gerontol 2018 Jul - Aug;23(132):45-48

c/o Soins Gérontologie, Elsevier Masson, 65 rue Camille-Desmoulins, 92442 Issy-les-Moulineaux cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.sger.2018.05.012DOI Listing
December 2018

Pensons aux aînés.

Soins Gerontol 2018 Jul - Aug;23(132)

c/o Soins Gérontologie, Elsevier Masson, 65 rue Camille-Desmoulins, 92442 Issy-les-Moulineaux cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.sger.2018.05.001DOI Listing
December 2018

"As du Coeur" study: a randomized controlled trial on quality of life impact and cost effectiveness of a physical activity program in patients with cardiovascular disease.

BMC Cardiovasc Disord 2018 Dec 6;18(1):225. Epub 2018 Dec 6.

Département de Santé Publique, Centre Hospitalier Universitaire de Nice (Public Health Department University Hospital of Nice), F-06202, Nice, France.

Background: Physical activity programs (PAP) in patients with cardiovascular disease require evidence of cost-utility. To assess improvement in health-related quality of life (QoL) and reduction of health care consumption of patients following PAP, a randomized trial was used.

Methods: Patients from a health insurance company who had experienced coronary artery disease or moderate heart failure were invited to participate (N = 1891). Read More

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http://dx.doi.org/10.1186/s12872-018-0973-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284296PMC
December 2018

Can patients be trained to expect shared decision making in clinical consultations? Feasibility study of a public library program to raise patient awareness.

PLoS One 2018 12;13(12):e0208449. Epub 2018 Dec 12.

Tier 1 Canada Research Chair in Shared Decision Making and Knowledge Translation, Université Laval, Quebec City (QC, Canada).

Introduction: Shared decision making (SDM) is a process whereby decisions are made together by patients and/or families and clinicians. Nevertheless, few patients are aware of its proven benefits. This study investigated the feasibility, acceptability and impact of an intervention to raise public awareness of SDM in public libraries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208449PLOS
December 2018
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Use of Micronized Purified Flavonoid Fraction Together with Rivaroxaban Improves Clinical and Ultrasound Outcomes in Femoropopliteal Venous Thrombosis: Results of a Pilot Clinical Trial.

Adv Ther 2018 Dec 11. Epub 2018 Dec 11.

Pirogov Russian National Research Medical University, Moscow, Russian Federation.

Introduction: The aim of this study was to assess the impact of adding long-term micronized purified flavonoid fraction (MPFF) to standard treatment of femoropopliteal deep vein thrombosis (DVT).

Methods: This pilot, comparative, open-label study with blinded outcome assessor enrolled patients with a first episode of femoropopliteal DVT confirmed by duplex ultrasound scanning (DUS). All participants were randomly allocated to one of two treatment groups: (1) control that received a standard treatment with oral rivaroxaban, and (2) experimental that involved additional treatment with MPFF 1000 mg/day. Read More

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http://dx.doi.org/10.1007/s12325-018-0849-zDOI Listing
December 2018

Effects of Repeated-Sprint Training in Hypoxia on Tennis-Specific Performance in Well-Trained Players.

Sports Med Int Open 2018 Sep 25;2(5):E123-E132. Epub 2018 Sep 25.

ISSUL, Institute of Sport Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

This study examined the physiological, physical and technical responses to repeated-sprint training in normobaric hypoxia [RSH, inspired fraction of oxygen (FiO ) 14.5%] vs. normoxia (RSN, FiO 20. Read More

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http://dx.doi.org/10.1055/a-0719-4797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259464PMC
September 2018

Broken needle during spinal anesthesia: an avoidable complication.

Local Reg Anesth 2018 23;11:111-113. Epub 2018 Nov 23.

Department of Anesthesia, Ales-en-Cévennes Hospital, Alès-en-Cévennes, France.

The occurrence of a needle breaking is a very rare complication of spinal anesthesia (SA). We report a case of a broken spinal needle occurring in a morbid obese pregnant woman during SA indicated for an emergent cesarean section. Multiple puncture attempts due to difficult identification of lumbar spine, associated with an inadequate use of the introducer, contributed to this complication. Read More

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https://www.dovepress.com/broken-needle-during-spinal-anesth
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http://dx.doi.org/10.2147/LRA.S175547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260186PMC
November 2018
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Discrepancies of assessments in a RECIST 1.1 phase II clinical trial - association between adjudication rate and variability in images and tumors selection.

Cancer Imaging 2018 Dec 11;18(1):50. Epub 2018 Dec 11.

Radiology, National Koranyi Institute of TB and pulmonology, Budapest, H-1121, Hungary.

Background: In imaging-based clinical trials, it is common practice to perform double reads for each image, discrepant interpretations can result from these two different evaluations. In this study we analyzed discrepancies that occurred between local investigators (LI) and blinded independent central review (BICR) by comparing reader-selected imaging scans and lesions. Our goal was to identify the causes of discrepant declarations of progressive disease (PD) between LI and BICR in a clinical trial. Read More

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http://dx.doi.org/10.1186/s40644-018-0186-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288919PMC
December 2018

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents.

Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.

Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.

Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X183013
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http://dx.doi.org/10.1016/j.jcmgh.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280602PMC
September 2018
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Three diagnostic psychiatric subgroups in comparison to self-stigma, quality of life, disorder severity and coping management cross-sectional outpatient study.

Neuro Endocrinol Lett 2018 Oct 12;39(4):331-341. Epub 2018 Oct 12.

Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, and University Hospital Olomouc, Czech Republic.

Background: Much attention has been paid to psychological factors influencing characteristics, severity, and course of mental disorders. The objective of our investigation was to examine the interrelations among quality of life (QoL), self-stigma, and coping strategies, demographics and severity of the disorder in neurotic spectrum disorders, schizophrenia, and depressive spectrum disorders.

Methods: A total of 343 clinically stable Czech outpatients with different mental disorders (153 with neurotic spectrum disorders; 81 with depression, and 109 with schizophrenia spectrum disorders) were included. Read More

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October 2018

Pathological markers of somatotroph pituitary neuroendocrine tumors (PitNET)s predicting the response to medical treatment.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Lyon 1, Université de Lyon, Lyon, France -

Acromegaly is mainly due to the somatotroph pituitary neuroendocrine tumors (PitNET)s. These have been subtyped into densely granulated (DG) and sparsely granulated (SG) tumors, which differ in clinical, histological and biological characteristics and in response to somatostatin analogs (SA)s. The variable remission rate after surgical resection, as first line treatment, has increased interest in identifying pathological markers to better predict the response to medical treatment. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02933-4DOI Listing
December 2018

Planned Mode of Delivery of Preterm Twins and Neonatal and 2-Year Outcomes.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, and Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France; EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal; the Department of Neonatal Pediatrics and Intensive Care and Neuropediatrics, Charles-Nicolle University Hospital, Rouen, INSERM U1245, Genetics and Pathophysiology of Neurodevelopmental Disorders, Team 4 Neovasc, Institute of Research and Innovation in Biomedicine, Rouen School of Medicine, Normandy University, Normandy, and the Department of Obstetrics and Gynecology, Cochin, Broca, Hôtel Dieu Hospital, Assistance Publique-Hôpitaux de Paris, the Department of Obstetrics and Gynecology, Trousseau University Hospital, Assistance Publique-Hôpitaux de Paris, and Sorbonne Universités, UPMC Univ Paris 06, IFD, 4 Place Jussieu, 75252 PARIS cedex 05, Paris, France.

Objective: To assess neonatal and 2-year outcomes for preterm twins born after planned vaginal delivery compared with planned cesarean delivery.

Methods: Women with preterm cephalic first twins delivered after preterm labor or preterm prelabor rupture of membranes from 24 0/7 to 34 6/7 weeks of gestation, with both fetuses alive at the beginning of labor, were identified from the national prospective population-based Etude Epidémiologique sur les Petits Ages Gestationnels 2 cohort study. Planned vaginal delivery was defined as vaginal delivery or cesarean delivery performed during labor. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003004DOI Listing
December 2018
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Physical Activity Is Associated with Attenuated Disease Progression in COPD.

Med Sci Sports Exerc 2018 Dec 7. Epub 2018 Dec 7.

ISGlobal, Barcelona, Spain[ZERO WIDTH SPACE].

Introduction: COPD progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression.

Method: We studied 114 COPD patients from the PAC-COPD cohort [94% male, mean (SD) 70 (8) years of age, 54 (16) FEV1 % predicted] at baseline and 2. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001859DOI Listing
December 2018

Ontogenesis of human fetal testicular steroidogenesis at early gestational age.

Steroids 2018 Dec 4;141:96-103. Epub 2018 Dec 4.

Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Stockholm, Sweden. Electronic address:

The onset of steroidogenesis in human fetal testes (HFT) during the first trimester is poorly investigated. One important unresolved question is the ontogeny of steroidogenic enzymes and formation of steroidogenic pathways in the HFT at early pregnancy. Our aim was to explore steroidogenesis, the expression of steroidogenic enzymes and their maturation in the HFT at gestational weeks (GW) 8-12. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.001DOI Listing
December 2018

The Actor-Partner Interdependence Model in shared decision making: An illustrative example of its application to the physician-patient dyad in primary care consultations.

J Clin Epidemiol 2018 Dec 6. Epub 2018 Dec 6.

Centre de recherche sur les soins et les services de première ligne de l'Université Laval (CERSSPL-UL), Pavillon Landry-Poulin, 2525, chemin de la Canardière, Quebec, QC, G1J 0A4, Canada; Department of Family and Emergency Medicine, Université Laval, 1050 Avenue de la Médecine, Quebec City, Quebec, G1V 0A6, Canada. Electronic address:

Objectives: We applied the Actor-Partner Interdependence Model, a method used to evaluate the relationship process between two related persons, to patient/physician data about the effect of shared decision-making behaviors on patient and physician uncertainty. We discuss measurement and interpretation problems.

Study Design And Setting: The EXACKTE project was a cross-sectional study of 263 unique patient-physician dyads in 17 primary care clinics in Canada. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2018.11.027DOI Listing
December 2018