27,203 results match your criteria Les Cahiers da€™Ophtalmologie [Journal]


Real-Time PCR based test for the early diagnosis of Haplosporidium pinnae affecting fan mussel Pinna nobilis.

PLoS One 2019 22;14(2):e0212028. Epub 2019 Feb 22.

IFAPA Agua del Pino, Cartaya, Huelva, Spain.

Noble pen shell or fan mussel, Pinna nobilis Linnaeus (1758), protected since 1992, was incorporated into the Spanish Catalogue of Threatened Species (Category: Vulnerable, Royal Decree 139/2011). The status is presently in the process of being catalogued as critically endangered, pending approval by Spanish Government (https://www.mapama. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212028PLOS
February 2019

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Objectives/hypothesis: To report the clinical safety and efficacy of three-dimensional (3D)-printed, patient-specific, bioresorbable airway splints in a cohort of critically ill children with severe tracheobronchomalacia.

Study Design: Case series.

Methods: From 2012 to 2018, 15 subjects received 29 splints on their trachea, right and/or left mainstem bronchi. Read More

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http://dx.doi.org/10.1002/lary.27863DOI Listing
February 2019

No correlation between lunar and menstrual cycle - an early report by the french physician J. A. Murat in 1806.

Authors:
Björn Lemmer

Chronobiol Int 2019 Feb 22:1-4. Epub 2019 Feb 22.

a Experimental Pharmacology Mannheim , Ruprecht-Karls-University of Heidelberg , Mannheim , Germany.

Jean Arnaud Murat was a physician at the Medical School of Montpellier in France. In 1806 he published his outstanding book "De L'Influence de la Nuit sur les Maladies ou Traité des Maladies Nocturne". In his book he concentrated on the following questions: - Does the night has an influence on a disease? - Are there diseases in which this is more or less obvious? - What is the physical background of this influence? Murat described in detail certain diseases which dominate at night and he concluded that the most evident motivation for his observations is the constant and periodic movement of the earth around its axis, resulting in a period of about 24 h, and the elliptic rotation around the sun. Read More

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http://dx.doi.org/10.1080/07420528.2019.1583669DOI Listing
February 2019

Letter to the editors: Measuring LES and UES basal pressure.

Neurogastroenterol Motil 2019 Mar;31(3):e13502

Department of Gastroenterology and Hepatology, Amsterdam Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/nmo.13502DOI Listing

Reply to the letter "Measuring LES and UES basal pressure".

Neurogastroenterol Motil 2019 Mar;31(3):e13516

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/nmo.13516DOI Listing

Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse.

Andrology 2019 Feb 22. Epub 2019 Feb 22.

Reproduction, Mother and Child Health, Centre de Recherche du CHU de Québec-Université Laval, Quebec, QC, Canada.

Background: GATA4 is a transcription factor essential for male sex determination, testicular differentiation during fetal development, and male fertility in the adult. GATA4 exerts part of its function by regulating multiple genes in the steroidogenic enzyme pathway. In spite of these crucial roles, how the activity of this factor is regulated remains unclear. Read More

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http://dx.doi.org/10.1111/andr.12601DOI Listing
February 2019

The Ethics of Eliminating Harmful Species: The Case of the Tsetse Fly.

Bioscience 2019 Feb 19;69(2):125-135. Epub 2018 Dec 19.

Department of Forest Ecosystems and Society at Oregon State University, in Corvallis.

Wildlife species harmful to humans are often targets of control and elimination programs. A contemporary example is the tsetse fly, a vector of sleeping sickness and African animal trypanosomosis. Tsetse flies have recently been targeted by a pan-African eradication campaign. Read More

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http://dx.doi.org/10.1093/biosci/biy155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377282PMC
February 2019

Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons.

Toxins (Basel) 2019 Feb 19;11(2). Epub 2019 Feb 19.

UMR U1179 INSERM/Université de Versailles Saint Quentin en Yvelines (UVSQ)-Paris Saclay, 78180 Montigny-le-Bretonneux, France.

A set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains (LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties have been assessed in primary cultures of rat embryonic dorsal root ganglia (DRG) neurons, and in organotypic cultures of explanted DRG from adult rats. Following infection of primary cultures of rat embryonic DRG neurons, the different BoNT LC induced efficient cleavage of their corresponding target Soluble N-ethylmaleimide-sensitive-factor Attachment protein Receptor (SNARE) protein (VAMP, SNAP25, syntaxin). Read More

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http://dx.doi.org/10.3390/toxins11020123DOI Listing
February 2019

High risk of heart failure associated with desmoglein-2 mutations compared to plakophilin-2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia.

Eur J Heart Fail 2019 Feb 21. Epub 2019 Feb 21.

Centre de Référence Pour les Maladies Cardiaques Héréditaires, APHP, Hôpital de la Pitié Salpêtrière, Paris, France.

Background: Previous studies suggested that genetic status affects the clinical course of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) patients. The aim of this study was to compare the outcome of desmoglein-2 (DSG2) mutation carriers to those who carry the plakophilin-2 (PKP2) mutation, the most common ARVC/D-associated gene.

Methods And Results: Consecutive ARVC/D patients carrying a pathogenic mutation in PKP2 or DSG2 were selected from a national ARVC/D registry. Read More

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http://dx.doi.org/10.1002/ejhf.1423DOI Listing
February 2019

[Imported Malaria in the Region of Marrakech-Safi, Morocco, between 1996 and 2016].

Bull Soc Pathol Exot 2018 ;111(2):104-108

Laboratoire de biotechnologie, environnement et qualité, département de biologie, faculté des sciences, université Ibn-Tofaïl, Kénitra, Maroc.

Since the elimination of the autochthonous malaria in Morocco in 2005, the control of imported malaria, based on epidemiological monitoring of the parasite carriers and on vector control, is a priority. This retrospective study is focused on imported malaria cases identified by optical microscopy at the Laboratory of Public Health in Marrakesh, Morocco, from 1996 to 2016. 208 cases were observed. Read More

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http://dx.doi.org/10.3166/bspe-2018-0014DOI Listing
January 2018

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor.

Nucleic Acids Res 2019 Feb 21. Epub 2019 Feb 21.

Unité de Génétique moléculaire, Institut Pasteur, CNRS ERL 3526, 75724 Paris Cedex 15, France.

Upon triggering by their inducer, signal transduction ATPases with numerous domains (STANDs), initially in monomeric resting forms, multimerize into large hubs that activate target macromolecules. This process requires conversion of the STAND conserved core (the NOD) from a closed form encasing an ADP molecule to an ATP-bound open form prone to multimerize. In the absence of inducer, autoinhibitory interactions maintain the NOD closed. Read More

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http://dx.doi.org/10.1093/nar/gkz112DOI Listing
February 2019

Offspring Microbiomes Differ Across Breeding Sites in a Panmictic Species.

Front Microbiol 2019 6;10:35. Epub 2019 Feb 6.

Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany.

High dispersal rates are known to homogenize host's population genetic structure in panmictic species and to disrupt host local adaptation to the environment. Long-distance dispersal might also spread micro-organisms across large geographical areas. However, so far, to which extent selection mechanisms that shape host's population genetics are mirrored in the population structure of the enteric microbiome remains unclear. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372503PMC
February 2019

Quality of life, self-stigma, and coping strategies in patients with neurotic spectrum disorders: a cross-sectional study.

Psychol Res Behav Manag 2019 1;12:81-95. Epub 2019 Feb 1.

Department of Psychiatry, University Hospital Olomouc, Olomouc, Czech Republic,

Background: Modern psychiatry focuses on self-stigma, coping strategies, and quality of life (QoL). This study looked at relationships among severity of symptoms, self-stigma, demographics, coping strategies, and QoL in patients with neurotic spectrum disorders.

Methods: A total of 153 clinically stable participants who met criteria for generalized anxiety disorder, social phobia, panic disorder, agoraphobia, mixed anxiety-depressive disorder, adjustment disorders, somatoform disorders, or obsessive-compulsive disorder were included in a cross-sectional study. Read More

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http://dx.doi.org/10.2147/PRBM.S179838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363490PMC
February 2019

La version franco-canadienne du « STrengthening the Reporting of OBservational studies in Epidemiology » (STROBE) Statement : L’outil STROBE.

Physiother Can 2019 ;71(1):1-10

Laboratoire de recherche en audition.

The main purpose is to produce a French-Canadian translation of the "STrengthening the Reporting of OBservational studies in Epidemiology" (STROBE) Statement under the proposed name of "outil STROBE" and to assess the cross-cultural validity of its content. The secondary purpose is to examine its preliminary interrater reliability. A modified approach to Vallerand's cross-cultural validation methodology was used. Read More

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http://dx.doi.org/10.3138/ptc.2017-49.fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373596PMC
January 2019

Degradation of mRNA by IRE1 repositions lysosomes and protects cells from stress.

J Cell Biol 2019 Feb 20. Epub 2019 Feb 20.

School of Biological Sciences, University of Utah, Salt Lake City, UT

Cells respond to stress in the ER by initiating the widely conserved unfolded protein response. Activation of the ER transmembrane nuclease IRE1 leads to the degradation of specific mRNAs, but how this pathway affects the ability of cells to recover from stress is not known. Here, we show that degradation of the mRNA encoding biogenesis of lysosome-related organelles 1 subunit 1 () leads to the repositioning of late endosomes (LEs)/lysosomes to the microtubule-organizing center in response to stress in mouse cells. Read More

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http://dx.doi.org/10.1083/jcb.201809027DOI Listing
February 2019

Efficiency of degradation or desorption methods in antineoplastic drug decontamination: A critical review.

J Oncol Pharm Pract 2019 Feb 20:1078155219831427. Epub 2019 Feb 20.

1 Pharmacy, Geneva University Hospitals and School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

Although considerable efforts have been made over the last 40 years, occupational exposure to antineoplastic drugs is still a daily concern, since eradicating such contamination from workplaces seems unattainable. Considerable data are currently available on the risks associated with their use at work. Hospital facilities are often cleaned with marketed antimicrobials whose chemical decontamination efficacy certainly differs but remains unknown. Read More

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http://dx.doi.org/10.1177/1078155219831427DOI Listing
February 2019

Functional analysis finds differences on the muscle transcriptome of pigs fed an n-3 PUFA-enriched diet with or without antioxidant supplementations.

PLoS One 2019 20;14(2):e0212449. Epub 2019 Feb 20.

Interdepartmental Centre for Industrial Agrifood Research (CIRI- AGRO), University of Bologna, Cesena, Italy.

Supplementing pig diets with n-3 polyunsaturated fatty acids (n-3 PUFA) may produce meat products with an increased n-3 fatty acid content, and the combined antioxidants addition could prevent lipid oxidation in the feed. However, to date, the effects of these bioactive compounds at the molecular level in porcine skeletal muscle are mostly unknown. This study aimed to analyse changes in the Longissimus thoracis transcriptome of 35 pigs fed three diets supplemented with: linseed (L); linseed, vitamin E and Selenium (LES) or linseed and plant-derived polyphenols (LPE). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212449PLOS
February 2019

[Renal risks of NSAIDs in endurance sports].

Rev Med Suisse 2019 Feb;15(639):444-447

Faculté de médecine, Université de Genève, 1205 Genève 4.

Endurance athletes, either professional or amateur, are consuming non steroidal anti-inflammatory drugs (NSAIDs) during their training and races. The goal is to decrease pain or to prevent a potential pain. These athletes, especially, the amateurs, do not do not know the side effects and have no medical supervision. Read More

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February 2019

[The vascular access of hemodialysis patients - What should the primary care physician know about ?]

Rev Med Suisse 2019 Feb;15(639):439-443

Service de chirurgie thoracique, Département Cœur-Vaisseaux, CHUV, 1011 Lausanne.

The most frequent dialysis modality in Switzerland is hemodialysis. Patients need a proper vascular access for this modality. There are three types of vascular access for hemodialysis : arteriovenous fistula, arteriovenous graft and central venous catheters. Read More

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February 2019

[Hepatorenal syndrome : something new?]

Rev Med Suisse 2019 Feb;15(639):432-435

Service de néphrologie, HUG, 1211 Genève 14.

Hepatorenal syndrome is a serious and frequent complication in patients suffering from liver cirrhosis. Its most severe type is characterized by the rapid occurrence of a functional acute kidney injury. However it is mainly an exclusion diagnosis. Read More

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February 2019

[Prescribing intravenous fluids in hospitalized patients : from need to harm].

Rev Med Suisse 2019 Feb;15(639):427-431

Service de néphrologie et hypertension, Département de médecine interne, CHUV, 1011 Lausanne.

Prescribing intravenous fluids in a hospital setting is a task that each clinician has to endorse in an everyday practice. This task is universal to the point that it is often undervalued, or even neglected during clinical teaching. However, one shouldn't underestimate the risks related to excessive fluid administration, of which the clinician often doesn't know the exact composition. Read More

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February 2019

[Metformin-associated lactic acidosis : myth or reality ?]

Rev Med Suisse 2019 Feb;15(639):422-426

Service de néphrologie, HUG, 1211 Genève 14.

Metformin is the first line therapy for patients with diabete type 2. However, the molecule is known to be responsible for lactic acidosis through its inhibition of the mitochondrial respiratory chain complex, a pathology called MALA (metformin associated lactic acidosis). This complication has been widely discussed in the literature because its development is usually the result of a multifactorial and complex process. Read More

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February 2019

[The skin as « third kidney »].

Rev Med Suisse 2019 Feb;15(639):418-421

Service de néphrologie et d'hypertension, CHUV, 1011 Lausanne.

The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume and blood pressure homeostasis. Read More

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February 2019

Produced water treatment by advanced oxidation processes.

Sci Total Environ 2019 Feb 10;666:12-21. Epub 2019 Feb 10.

Departament d' Enginyeria Química, Universitat Rovira i Virgili, Av Països Catalans 26, 43007 Tarragona, Spain. Electronic address:

Different Advanced Oxidation Processes (AOPs) such as photocatalysis, Fenton-based processes and ozonation were studied to include one of these technologies within an integrated solution for produced water (PW) polishing. Synthetic PW was prepared adding toluene, xylene, naphthalene, phenol, acetic and malonic acids to a seawater matrix. Despite that in all AOPs studied in this work BTEX and naphthalene were removed, the efficiency (in terms of TOC removal) of each treatment varied largely. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.128DOI Listing
February 2019

Exclusion of Intra-Atrial Thrombus Diagnosis Using D-Dimer Assay Before Catheter Ablation of Atrial Fibrillation.

JACC Clin Electrophysiol 2019 Feb 1;5(2):223-230. Epub 2018 Nov 1.

CHU Rouen, Rouen, France.

Objectives: This study hypothesized that the association of D-dimer blood level and several clinical items in a new risk score could predict the absence of atrial thrombus.

Background: Symptomatic and drug resistant atrial fibrillation (AF) can be treated by catheter ablation. The procedure-related risk of thromboembolism is limited by the pre-operative use of transesophageal echocardiography (TEE) to detect atrial thrombi. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2405500X183079
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http://dx.doi.org/10.1016/j.jacep.2018.09.009DOI Listing
February 2019
1 Read

N 375 - Directive clinique sur l'utilisation de l'échographie au premier trimestre.

J Obstet Gynaecol Can 2019 Mar;41(3):396-404

Sherbrooke (Qc).

Objectif: Révision des indications cliniques de l'échographie du premier trimestre. RéSULTATS: L'échographie au premier trimestre offre des avantages cliniques démontrés. DONNéES PROBANTES: Les données probantes ont été révisées au moyen de recherche dans Medline et selon la bibliographie des articles pertinents. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.12.002DOI Listing
March 2019
1 Read

N 374 - Évaluation systématique de la longueur cervicale.

J Obstet Gynaecol Can 2019 Mar;41(3):375-387.e1

Toronto (Ont.).

Objectif: Passer en revue les données probantes et fournir une opinion indiquant si l'évaluation systématique de la longueur cervicale pour la prévention de l'accouchement prématuré devrait être adoptée au Canada. RéSULTATS: Les issues évaluées comprennent la prévention de l'accouchement prématuré. DONNéES PROBANTES: Nous avons interrogé les bases de données Knowledge Finder, Medline et Cochrane pour en tirer les articles publiés jusqu'en avril 2018 sur la mesure de la longueur cervicale pour la prévention de l'accouchement prématuré. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.01.003DOI Listing

Énoncé d'éthique sur Les pratiques en santé mondiale.

J Obstet Gynaecol Can 2019 Mar;41(3):270-272

Département d'obstétrique et de gynécologie, Université d'Ottawa, Ottawa (Ont.); Société des obstétriciens et gynécologues du Canada, Ottawa (Ont.).

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http://dx.doi.org/10.1016/j.jogc.2018.12.017DOI Listing

Thermogenic capacity in subterranean Ctenomys: Species-specific role of thermogenic mechanisms.

J Therm Biol 2019 Feb 1;80:164-171. Epub 2019 Feb 1.

Laboratorio de Ecología Fisiológica y del Comportamiento, Instituto de Investigaciones Marinas y Costeras (IIMyC), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata CC1245, Argentina.

One way to understand ecological patterns of species is to determine their physiological diversity on a large geographic and/or temporal scales, in a context of hierarchical biodiversity framework. In particular, macrophysiological studies analyze how environmental factors affect the physiology and therefore the distribution of species. Subterranean species are an excellent model for evaluating the large-scale effects of ambient temperature (T) conditions on thermal physiology and distribution, due to their extensive use of burrows that provide a relatively thermal stable environment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064565183047
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http://dx.doi.org/10.1016/j.jtherbio.2019.01.012DOI Listing
February 2019
1 Read

Inhibition of the CD40/CD40L complex protects mice against ALI-induced pancreas degradation.

Transfusion 2019 Feb 19. Epub 2019 Feb 19.

Université de Lyon, GIMAP-EA3064, Saint-Etienne, France.

Background: Acute lung injury (ALI) is a severe complication of transfusion. In a previous study, we saw that inhibition of the CD40/CD40L complex allowed restoration of ALI lesions in an experimental mouse model.

Objectives: This study focused on pancreas-associated injury development during experimental ALI pathogenesis and its limitation through CD40/CD40L complex inhibition. Read More

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http://dx.doi.org/10.1111/trf.15206DOI Listing
February 2019

Les traits d'identité culturelle en lien avec le statut d'immigrant et l'ethnicité : quel lien avec les symptômes de détresse psychologique et les symptômes dépressifs dans la main-d'œuvre canadienne? Résultats des neuf cycles de l'ENSP.

Can J Public Health 2019 Feb 19. Epub 2019 Feb 19.

L'École des Relations Industrielles, Université de Montréal, Montréal (Québec), Pavillon Lionel-Groulx, École de relations industrielles CP 6128, Succursale Centre-ville Montréal, QC, H3C 3J7, Canada.

Purpose: This study investigated variations over time of psychological distress and depressive symptoms among working Canadians according to two cultural identity traits: ethnicity and immigration status.

Method: Data came from the nine cycles of the National Population Health Survey (NPHS) conducted by Statistics Canada. Based on a sample of 7069 workers, multiple regressions analyses and multilevel regressions models were carried out. Read More

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http://dx.doi.org/10.17269/s41997-019-00186-4DOI Listing
February 2019

Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers.

Sci Rep 2019 Feb 19;9(1):2274. Epub 2019 Feb 19.

Department of Neurology, Boston University School of Medicine Boston, Massachusetts, 02118, USA.

We present a plasmid-based system in which upstream trans-splicing efficiently generates mRNAs that encode head-to-tail protein multimers. In this system, trans-splicing occurs between one of two downstream splice donors in the sequence encoding a C-terminal V5 epitope tag and an upstream splice acceptor in the 5' region of the pCS2(+) host plasmid. Using deletion and fusion constructs of the DUX4 protein as an example, we found that this system produced trans-spliced mRNAs in which coding regions from independent transcripts were fused in phase such that covalent head-to-tail protein multimers were translated. Read More

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http://www.nature.com/articles/s41598-018-36684-7
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http://dx.doi.org/10.1038/s41598-018-36684-7DOI Listing
February 2019
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Exceptionally high δN values in collagen single amino acids confirm Neandertals as high-trophic level carnivores.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.

Isotope and archeological analyses of Paleolithic food webs have suggested that Neandertal subsistence relied mainly on the consumption of large herbivores. This conclusion was primarily based on elevated nitrogen isotope ratios in Neandertal bone collagen and has been significantly debated. This discussion relies on the observation that similar high nitrogen isotopes values could also be the result of the consumption of mammoths, young animals, putrid meat, cooked food, freshwater fish, carnivores, or mushrooms. Read More

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http://dx.doi.org/10.1073/pnas.1814087116DOI Listing
February 2019

Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies.

CMAJ 2019 Feb;191(7):E179-E187

Research Centre (Bérard, Sheehy, Zhao, Gorgui), CHU Sainte-Justine; Faculty of Pharmacy (Bérard, Gorgui), University of Montreal; Faculty of Medicine (Bernatsky, Moura), McGill University; Faculty of Medicine, Department of Clinical Epidemiology (Abrahamowicz), McGill University, Montréal, Que.

Background: While topical azoles are the first-line treatment for fungal infections, oral fluconazole is frequently used during pregnancy. We aimed to assess the effect of exposure to low and high doses of fluconazole during pregnancy on the occurrence of spontaneous abortions, major congenital malformations and stillbirths.

Methods: Within the Quebec Pregnancy Cohort (1998-2015), we identified women exposed to low- (≤ 150 mg) and high-dose (> 150 mg) fluconazole, and women who were not exposed. Read More

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http://dx.doi.org/10.1503/cmaj.180963DOI Listing
February 2019

Italian translation, cultural adaptation, and pilot testing of a questionnaire to assess family burden in inherited ichthyoses.

Ital J Pediatr 2019 Feb 19;45(1):26. Epub 2019 Feb 19.

Department of Dermatology, Necker-Enfants Malades Hospital, Centre de Référence National pour les Maladies Génétiques à Expression Cutanée (MAGEC), APHP, Paris, France.

Background: Inherited ichthyoses are rare disorders characterized by generalized skin scaling. Among them, autosomal recessive congenital ichthyoses (ARCI) form a major subgroup presenting lifelong and severely disabling cutaneous and extracutaneous features and symptoms for which no curative treatment is available. Management relies on daily time-consuming and distressing topical medications. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
Publisher Site
http://dx.doi.org/10.1186/s13052-019-0618-xDOI Listing
February 2019
1 Read

Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators.

J Affect Disord 2019 Feb 6;249:242-252. Epub 2019 Feb 6.

Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden.

Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.010DOI Listing
February 2019

Spatial and temporal development of deltamethrin resistance in malaria vectors of the Anopheles gambiae complex from North Cameroon.

PLoS One 2019 19;14(2):e0212024. Epub 2019 Feb 19.

Institut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon.

The effectiveness of insecticide-based malaria vector control interventions in Africa is threatened by the spread and intensification of pyrethroid resistance in targeted mosquito populations. The present study aimed at investigating the temporal and spatial dynamics of deltamethrin resistance in An. gambiae s. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212024PLOS
February 2019

Long-Distance Benefits of Marine Reserves: Myth or Reality?

Trends Ecol Evol 2019 Feb 8. Epub 2019 Feb 8.

MARBEC, Univ Montpellier, CNRS, IFREMER, IRD, Montpellier, France; Australian Research Council Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4811 Australia.

Long-distance (>40-km) dispersal from marine reserves is poorly documented; yet, it can provide essential benefits such as seeding fished areas or connecting marine reserves into networks. From a meta-analysis, we suggest that the spatial scale of marine connectivity is underestimated due to the limited geographic extent of sampling designs. We also found that the largest marine reserves (>1000km) are the most isolated. Read More

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http://dx.doi.org/10.1016/j.tree.2019.01.002DOI Listing
February 2019

Comparing pollution patterns and human exposure to atmospheric PBDEs and PCBs emitted from different e-waste dismantling processes.

J Hazard Mater 2019 Feb 10;369:142-149. Epub 2019 Feb 10.

Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, Guangdong, China. Electronic address:

Waste electrical and electronic equipment (E-waste) recycling provides post-consumption economic opportunities, can also exert stress on environment and human health. This study investigated emissions, compositional profiles, and health risks associated with polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) at five workshops (electric blowers to treat mobile phones (EBMP), electric heating furnaces to treat televisions (EHFTV) and routers (EHFR), and rotatory incinerators to treat televisions (RITV) and hard disks (RIHD)) within an e-waste dismantling industrial park. Total suspended particulate (TSP), PBDE, and PCB concentrations were 490-1530 μg m, 26. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043894193015
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http://dx.doi.org/10.1016/j.jhazmat.2019.02.029DOI Listing
February 2019
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Adaptive Introgression: An Untapped Evolutionary Mechanism for Crop Adaptation.

Front Plant Sci 2019 1;10. Epub 2019 Feb 1.

Institut de Recherche pour le Développement, UMR DIADE, Montpellier, France.

Global environmental changes strongly impact wild and domesticated species biology and their associated ecosystem services. For crops, global warming has led to significant changes in terms of phenology and/or yield. To respond to the agricultural challenges of this century, there is a strong need for harnessing the genetic variability of crops and adapting them to new conditions. Read More

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http://dx.doi.org/10.3389/fpls.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367218PMC
February 2019

Integrated Mobile Genetic Elements in Thaumarchaeota.

Environ Microbiol 2019 Feb 17. Epub 2019 Feb 17.

National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA.

To explore the diversity of mobile genetic elements (MGE) associated with archaea of the phylum Thaumarchaeota, we exploited the property of most MGE to integrate into the genomes of their hosts. Integrated MGE (iMGE) were identified in 20 thaumarchaeal genomes amounting to 2 Mbp of mobile thaumarchaeal DNA. These iMGE group into five major classes: (i) proviruses, (ii) casposons, (iii) insertion sequence-like transposons, (iv) integrative-conjugative elements, and (v) cryptic integrated elements. Read More

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http://dx.doi.org/10.1111/1462-2920.14564DOI Listing
February 2019

Ionization and fragmentation of uracil upon microhydration.

Phys Chem Chem Phys 2019 Feb 18. Epub 2019 Feb 18.

Laboratoire Physique et Chimie Théoriques UMR 7019, CNRS - Université de Lorraine, BP239, Boulevard des Aiguillettes, 54 506 Vandoeuvre-lès-Nancy-Cedex, France.

We study at the DFT level the ionization and the fragmentation of uracil in the presence of zero, one and two water molecules, to unravel the effect of microhydration on the reactivity of this nucleobase. We show that the microhydration lowers the adiabatic and vertical ionization potentials by 0.41 eV and 0. Read More

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http://dx.doi.org/10.1039/c8cp07452fDOI Listing
February 2019

Effectiveness of an on-body lifting aid (HAL® for care support) to reduce lower back muscle activity during repetitive lifting tasks.

J Clin Neurosci 2019 Feb 14. Epub 2019 Feb 14.

Department of General and Trauma Surgery, BG University Hospital, Bochum, Germany.

The Hybrid Assistive Limb Lumbar Type (HAL) is an active exoskeleton that provides motion according to the wearer's voluntary drive. It was developed to support back muscles during repetitive lifting tasks. The purpose of this paper was to determine if the myoelectric activity of the back muscles is reduced or altered when using the HAL and to investigate a possible influence of its use on the cardiovascular system. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.038DOI Listing
February 2019

Pharmacoepidemiology in older people: Purposes and future directions.

Therapie 2019 Jan 31. Epub 2019 Jan 31.

Aging Research Center, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

Knowledge of the benefit/risk ratio of drugs in older adults is essential to optimise medication use. While randomised controlled trials are fundamental to the process of drug development and bringing new drugs to the market, they often exclude older adults, especially those suffering from frailty, multimorbidity and/or receiving polypharmacy. Therefore, it is generally unknown whether the benefits and harms of drugs established through pre-marketing clinical trials are translatable to the real-word population of older adults. Read More

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http://dx.doi.org/10.1016/j.therap.2018.10.006DOI Listing
January 2019
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Cephalometric norms of a Burkina Faso population.

Int Orthod 2019 Feb 13. Epub 2019 Feb 13.

Institut d'odontostomatologie de Dakar, Dakar, Senegal.

Introduction: After a clinical examination, in order to implement an appropriate treatment planning, additional examinations such as lateral cephalograms, were performed. They were submitted to a cephalometric analysis such as the Tweed-Merrifield analysis. These cephalometric analyses based on a synthesis of aesthetic criteria established for a Caucasian European-American white people population could not serve as the reference for an African population. Read More

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http://dx.doi.org/10.1016/j.ortho.2019.01.002DOI Listing
February 2019

Prevalence and clinical patterns of ocular complications associated with anti-PD-1/PD-L1 anticancer immunotherapy.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Service d'Ophtalmologie, DHU Vision & Handicaps, Centre de référence pour les maladies rares en ophtalmologie (OPHTARA), F-94275, Le Kremlin-Bicêtre, France; Université Paris-Sud, F-94276, Le Kremlin-Bicêtre, France; INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, F-94276, Le Kremlin-Bicêtre, France; CEA, DSV/iMETI, IDMIT, F-92265, Fontenay-aux-Roses, France Department of Immunology of viral and auto-immune disease, (IMVA/ IDMIT), UMR1184, CEA, Fontenay-aux-Roses. Electronic address:

Purpose: Immune checkpoint inhibitors (ICI) targeting the programmed cell death protein 1 (PD-1), or its ligand PD-L1, are the mainstay of metastatic cancer treatment. Patients receiving these treatments may develop immune-related adverse events (irAEs). This study aimed to estimate the prevalence and describe the clinical patterns of moderate to severe ocular irAEs-associated with anti-PD-(L)1 treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.012DOI Listing
February 2019

Transcarotid Approach for Transcatheter Aortic Valve Replacement With the Sapien 3 Prosthesis: A Multicenter French Registry.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Lille University Hospital, Lille, France. Electronic address:

Objectives: This study sought to describe the procedural and clinical outcomes of patients undergoing transcarotid (TC) transcatheter aortic valve replacement (TAVR) with the Edwards Sapien 3 device.

Background: The TC approach for TAVR holds the potential to become the optimal alternative to the transfemoral gold standard. Limited data exist regarding safety and efficacy of TC-TAVR using the Edwards Sapien 3 device. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.11.014DOI Listing
February 2019

["We need to modernise hospital pathways to favour prevention!"]

Authors:
Nicolas Biard

Soins 2019 Jan - Feb;64(832):41-43

c/o Soins, Elsevier Masson SAS, 92442 Issy-les-Moulineaux cedex, France. Electronic address:

In the hospital sector, care is often considered only from a curative perspective. However, improving screening for frailties and providing support with regard to risk factors would help care pathways evolve and place more emphasis on prevention. The hospital has a role as an institutional partner and whistleblower in the area of preventive health. Read More

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http://dx.doi.org/10.1016/j.soin.2018.12.010DOI Listing
February 2019

Préserver le capital santé des populations.

Authors:
Nicolas Biard

Soins 2019 Jan - Feb;64(832):15-52

c/o Soins, Elsevier Masson SAS, 65, rue Camille-Desmoulins, 92442 Issy-les-Moulineaux cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.soin.2018.12.002DOI Listing
February 2019