6,025 results match your criteria Leptospirosis in Humans


Systematic Review of Important Bacterial Zoonoses in Africa in the Last Decade in Light of the 'One Health' Concept.

Pathogens 2019 Apr 16;8(2). Epub 2019 Apr 16.

Infectious Diseases and Anti-Infective Therapy Research Group, Sharjah Medical Research Institute and College of Pharmacy, University of Sharjah, Sharjah 27272, UAE.

Zoonoses present a major public health threat and are estimated to account for a substantial part of the infectious disease burden in low-income countries. The severity of zoonotic diseases is compounded by factors such as poverty, living in close contact with livestock and wildlife, immunosuppression as well as coinfection with other diseases. The interconnections between humans, animals and the environment are essential to understand the spread and subsequent containment of zoonoses. Read More

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http://dx.doi.org/10.3390/pathogens8020050DOI Listing
April 2019
3 Reads

[Zoonoses related to leisure activities].

Authors:
Nadia Haddad

Rev Prat 2019 Mar;69(3):336-340

UMR BIPAR, Ecole nationale vétérinaire d'Alfort, Anses, INRA, université Paris-Est, Maisons- Alfort, France.

Zoonoses related to leisure activities. Many zoonoses can be contracted by humans during recreational activities. In the context of a walk, some of them, such as Lyme disease, are transmissible by biological vectors, particularly ticks, or by aerosol (Q fever, hantavirose), whereas others can be contracted in case of aquatic activities (leptospirosis), hunting (tularaemia), and visits to pet farms or fairs (especially the hemolytic uremic syndrome). Read More

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March 2019
3 Reads

Genomic analysis of Leptospira interrogans serovar Paidjan and Dadas isolates from carrier dogs and comparative genomic analysis to detect genes under positive selection.

BMC Genomics 2019 Mar 4;20(1):168. Epub 2019 Mar 4.

Department of Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

Background: Leptospirosis is an emerging infectious disease worldwide that can cause high morbidity and mortality rates in humans and animals. The causative spirochetes have reservoirs in mammalian hosts, but there has been limited analysis of the genomes of isolates recovered from animals. The aims of this study were to characterize genomic features of two Leptospira interrogans strains recently isolated from asymptomatic dogs in Thailand (strains CUDO5 and CDUO8), and to perform comparative genome analyses with other strains. Read More

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http://dx.doi.org/10.1186/s12864-019-5562-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399948PMC

A One Health Approach to Investigating Serogroups and Their Spatial Distributions among Humans and Animals in Rio Grande do Sul, Brazil, 2013⁻2015.

Trop Med Infect Dis 2019 Feb 27;4(1). Epub 2019 Feb 27.

Pan American Health Organization (PAHO/WHO), Washington, DC 20037, USA.

Leptospirosis is an endemic zoonotic disease in Brazil and is widespread throughout rural populations in the state of Rio Grande do Sul. This study aimed to identify presumptive infecting serogroups in human and animal cases and describe their occurrences within the ecoregions of the state by animal species. Data for human and animal leptospirosis cases were gathered from the government's passive surveillance systems and presumptive infecting serogroups were identified based on a two-fold titer difference in serogroups in the microscopic agglutination test (MAT) panel. Read More

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http://dx.doi.org/10.3390/tropicalmed4010042DOI Listing
February 2019

Leptospirosis.

Authors:
Dara Grennan

JAMA 2019 02;321(8):812

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http://dx.doi.org/10.1001/jama.2019.0697DOI Listing
February 2019
3 Reads

Sanitation workers from Portugal: Is there evidence of Leptospira spp?

J Infect Public Health 2019 Feb 15. Epub 2019 Feb 15.

Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Portugal; Global Health and Tropical Medicine (GHTM), UNL, Portugal.

Leptospires are spirochetes of Leptospira genus. Infection in humans occurs by penetration into the mucous membranes, or into the skin (small wounds or abrasions). Humans are infected when they contact with urine of rodents, the main reservoirs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193007
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http://dx.doi.org/10.1016/j.jiph.2019.02.001DOI Listing
February 2019
5 Reads

A simple score to predict severe leptospirosis.

PLoS Negl Trop Dis 2019 02 13;13(2):e0007205. Epub 2019 Feb 13.

Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.

Background: The case-fatality rate of severe leptospirosis can exceed 50%. While prompt supportive care can improve survival, predicting those at risk of developing severe disease is challenging, particularly in settings with limited diagnostic support.

Methodology/principal Findings: We retrospectively identified all adults with laboratory-confirmed leptospirosis in Far North Queensland, Australia, between January 1998 and May 2016. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391019PMC
February 2019

Identification of a novel protein in the genome sequences of Leptospira interrogans with the ability to interact with host's components.

J Microbiol Immunol Infect 2019 Jan 22. Epub 2019 Jan 22.

Laboratorio Especial de Desenvolvimento de Vacinas-Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, Sao Paulo, SP, Brazil. Electronic address:

Background: Leptospirosis is an infectious disease that affects humans and animals worldwide. The etiological agents of this disease are the pathogenic species of the genus Leptospira. The mechanisms involved in the leptospiral pathogenesis are not full understood. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.012DOI Listing
January 2019
1 Read

Pathogenic Leptospira species are widely disseminated among small mammals in Atlantic Forest biome.

Transbound Emerg Dis 2019 Jan 31. Epub 2019 Jan 31.

Universidade Federal Fluminense, Laboratório de Bacteriologia Veterinária, Instituto Biomédico, Niterói, Rio de Janeiro, Brazil.

Leptospirosis is a common worldwide bacterial zoonosis and has been studied in One Health approaches. Small mammals are described as the most important maintenance reservoirs of several pathogens in nature, including leptospires. The aim of this study was to identify infection by leptospires among small mammals on the Atlantic forest biome and evaluate their potential as carriers of these spirochetes. Read More

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http://dx.doi.org/10.1111/tbed.13135DOI Listing
January 2019
1 Read

Leptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay.

Transbound Emerg Dis 2019 Jan 26. Epub 2019 Jan 26.

Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Montevideo, Uruguay.

Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identification of the agent. Here, we report one confirmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5. Read More

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http://dx.doi.org/10.1111/tbed.13133DOI Listing
January 2019
6 Reads

Historical perspective: Leptospirosis outbreaks affecting military forces.

Authors:
Leslie L Clark

MSMR 2019 Jan;26(1):20-22

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January 2019

Junctional Rhythm: A Rare Sign in Leptospirosis.

Indian J Crit Care Med 2018 Dec;22(12):889-891

Department of Radiation Oncology, RIMS, Ranchi, Jharkhand, India.

Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311981PMC
December 2018
6 Reads

Despite high-risk exposures, no evidence of zoonotic transmission during a canine outbreak of leptospirosis.

Zoonoses Public Health 2019 03 7;66(2):223-231. Epub 2019 Jan 7.

Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.

Leptospirosis is a bacterial zoonosis that affects many mammals, including humans and dogs; dogs can transmit the bacteria to humans, but the frequency of transmission and highest risk exposures are poorly understood. During 2016-2017, the Maricopa County Department of Public Health, Arizona Department of Health Services and Centers for Disease Control and Prevention investigated the zoonotic potential of a canine leptospirosis outbreak in the Phoenix metro area. We identified symptomatic persons exposed to canine leptospirosis cases by conducting active and passive surveillance. Read More

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http://doi.wiley.com/10.1111/zph.12557
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http://dx.doi.org/10.1111/zph.12557DOI Listing
March 2019
22 Reads

Comparison of Mycobacterium ulcerans (Buruli ulcer) and Leptospira sp. (Leptospirosis) dynamics in urban and rural settings.

PLoS Negl Trop Dis 2019 01 7;13(1):e0007074. Epub 2019 Jan 7.

Equipe EA 3593, Ecosystèmes amazoniens et pathologie tropicale, Université de la Guyane, Cayenne, Guyane française.

Background: Zoonotic pathogens respond to changes in host range and/or pathogen, vector and host ecology. Environmental changes (biodiversity, habitat changes, variability in climate), even at a local level, lead to variability in environmental pathogen dynamics and can facilitate their transmission from natural reservoirs to new susceptible hosts. Whilst the environmental dynamics of aquatic bacteria are directly linked to seasonal changes of their habitat they also rely on the ecological processes underpining their transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336349PMC
January 2019
3 Reads

Human Mozdok leptospirosis first diagnosed by serum agglutinin-absorption tests in the Slovak Republic.

Epidemiol Mikrobiol Imunol Winter 2018;67(3):114-120

Introduction: The serovar Mozdok related leptospirosis in humans were not yet feasibly diagnosed using merely the standard micro-agglutination test (MAT) what was perhaps due to the impossibility to distinguish them from illnesses that are caused by Leptospira strains belonging to other serovars of the serogroup Pomona. On the contrary, leptospires of the Mozdok serovar were cultured from rodents and domestic animals world-wide including Central Europe where only Leptospira strains of the serovars Pomona and Mozdok are known to be present till now.

Study Objective: The aim of the study was to discover if leptospires of Mozdok serovar may cause human leptospirosis that remained hidden till now among infections diagnosed merely by MAT as Pomona illnesses. Read More

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April 2019
1 Read

Spatial epidemiological approaches to inform leptospirosis surveillance and control: A systematic review and critical appraisal of methods.

Zoonoses Public Health 2019 03 28;66(2):185-206. Epub 2018 Dec 28.

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.

Leptospirosis is a global zoonotic disease that the transmission is driven by complex geographical and temporal variation in demographics, animal hosts and socioecological factors. This results in complex challenges for the identification of high-risk areas. Spatial and temporal epidemiological tools could be used to support leptospirosis control programs, but the adequacy of its application has not been evaluated. Read More

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http://dx.doi.org/10.1111/zph.12549DOI Listing
March 2019
1 Read
2.065 Impact Factor

Leptospira infection and shedding in cats in Thailand.

Transbound Emerg Dis 2019 Mar 7;66(2):948-956. Epub 2019 Jan 7.

Clinic of Small Animal Internal Medicine, Centre of Clinical Veterinary Medicine LMU Munich, Munich, Germany.

In Thailand, leptospirosis is considered an emerging disease in humans and animals. Many species can shed pathogenic Leptospira, including domestic cats (felis catus), which might be able to pose a risk to humans. There are no studies on Leptospira infections in cats in Thailand, but in other countries, it was demonstrated that cats can shed pathogenic Leptospira with high prevalences. Read More

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http://doi.wiley.com/10.1111/tbed.13110
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http://dx.doi.org/10.1111/tbed.13110DOI Listing
March 2019
13 Reads

Development of real-time loop-mediated isothermal amplification (RealAmp) method for sensitive and rapid detection of pathogenic and nonpathogenic Leptospira.

Lett Appl Microbiol 2019 Feb;68(2):196-203

Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Leptospirosis is a zoonotic disease that is spread through water contaminated with the spirochete Leptospira. In our study, RealAmp (real-time loop-mediated isothermal amplification) was developed to distinguish between pathogenic and nonpathogenic Leptospira spp. Melt curve analysis of RealAmp showed two distinct melt curves for pathogenic and nonpathogenic Leptospira spp with a Tm value of 90 ± 2 and 88 ± 2°C. Read More

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http://doi.wiley.com/10.1111/lam.13108
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http://dx.doi.org/10.1111/lam.13108DOI Listing
February 2019
4 Reads

Leptospirosis complicated with Guillain Barre syndrome, papillitis and thrombotic thrombocytopenic Purpura; a case report.

BMC Infect Dis 2018 Dec 22;18(1):691. Epub 2018 Dec 22.

National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Background: Leptospirosis is a zoonosis commonly prevalent in tropical countries. Clinical course of leptospirosis varies from mild to severe disease. Here we present a case of leptospirosis complicated with Guillain-Barre Syndrome (GBS), papillitis, and Thrombotic Thrombocytopenic Purpura(TTP). Read More

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http://dx.doi.org/10.1186/s12879-018-3616-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303948PMC
December 2018
3 Reads

Leptospirosis.

Workplace Health Saf 2019 Mar 21;67(3):148. Epub 2018 Dec 21.

1 University of Alabama at Birmingham.

Leptospirosis is a leading zoonotic disease for morbidity and mortality in humans globally. Occupational health nurses should teach workers and the public about leptospirosis and the importance of disrupting the infection source through rodent control, animal vaccination, and flood prevention. Read More

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http://dx.doi.org/10.1177/2165079918818582DOI Listing

Data and tools to integrate climate and environmental information into public health.

Infect Dis Poverty 2018 Nov 29;7(1):126. Epub 2018 Nov 29.

The International Research Institute for Climate and Society, The Earth Institute, Columbia University, 61 Route 9W, Lamont-Doherty, Palisades, NY, 10964, USA.

Background: During the last 30 years, the development of geographical information systems and satellites for Earth observation has made important progress in the monitoring of the weather, climate, environmental and anthropogenic factors that influence the reduction or the reemergence of vector-borne diseases. Analyses resulting from the combination of geographical information systems (GIS) and remote sensing have improved knowledge of climatic, environmental, and biodiversity factors influencing vector-borne diseases (VBDs) such as malaria, visceral leishmaniasis, dengue, Rift Valley fever, schistosomiasis, Chagas disease and leptospirosis. These knowledge and products developed using remotely sensed data helped and continue to help decision makers to better allocate limited resources in the fight against VBDs. Read More

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http://dx.doi.org/10.1186/s40249-018-0501-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292116PMC
November 2018

Diagnostic accuracy of rapid diagnostic tests for the early detection of leptospirosis.

J Infect Public Health 2019 Mar - Apr;12(2):263-269. Epub 2018 Nov 27.

Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. Electronic address:

Background: Leptospirosis is often misdiagnosed with several other tropical febrile illnesses in Malaysia due to similarities in clinical manifestations. Although treatment regimens could be started based on clinical judgments, early diagnosis has become paramount as a guide to chemotherapeutic interventions. Confirmed laboratory diagnosis through MAT or PCR is time consuming and usually available only in reference laboratories and not practical in healthcare settings. Read More

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http://dx.doi.org/10.1016/j.jiph.2018.10.137DOI Listing

Molecular detection and clinical characteristics of Bartonella bacilliformis, Leptospira spp., and Rickettsia spp. in the Southeastern Peruvian Amazon basin.

BMC Infect Dis 2018 Dec 4;18(1):618. Epub 2018 Dec 4.

School of Medicine. Faculty of Health Sciences. Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Background: Acute febrile illness (AFI) represent a significant health challenge in the Peruvian Amazon basin population due to their diverse etiologies and the unavailability of specific on-site diagnostic methods, resulting in underreporting of cases. In Peru, one of the most endemic regions to dengue and leptospirosis is Madre de Dios, a region also endemic to emergent bacterial etiologic agents of AFI, such as bartonellosis and rickettsiosis, whose prevalence is usually underreported. We aimed to molecularly identify the presence of Leptospira spp. Read More

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http://dx.doi.org/10.1186/s12879-018-3541-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280516PMC
December 2018
3 Reads

A remotely sensed flooding indicator associated with cattle and buffalo leptospirosis cases in Thailand 2011-2013.

BMC Infect Dis 2018 Nov 29;18(1):602. Epub 2018 Nov 29.

Université Clermont Auvergne, Université de Lyon, INRA, VetAgro Sup, UMR EPIA, 63122, Saint Genès Champanelle, France.

Background: Leptospirosis is an important zoonotic disease worldwide, caused by spirochetes bacteria of the genus Leptospira. In Thailand, cattle and buffalo used in agriculture are in close contact with human beings. During flooding, bacteria can quickly spread throughout an environment, increasing the risk of leptospirosis infection. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3537-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267035PMC
November 2018
1 Read

A Cross-Cutting Approach to Surveillance and Laboratory Capacity as a Platform to Improve Health Security in Uganda.

Health Secur 2018 ;16(S1):S76-S86

Kiersten Kugeler, PhD, MPH, is an Epidemiologist, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO.

Global health security depends on effective surveillance for infectious diseases. In Uganda, resources are inadequate to support collection and reporting of data necessary for an effective and responsive surveillance system. We used a cross-cutting approach to improve surveillance and laboratory capacity in Uganda by leveraging an existing pediatric inpatient malaria sentinel surveillance system to collect data on expanded causes of illness, facilitate development of real-time surveillance, and provide data on antimicrobial resistance. Read More

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https://www.liebertpub.com/doi/10.1089/hs.2018.0051
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http://dx.doi.org/10.1089/hs.2018.0051DOI Listing
April 2019
36 Reads

Evaluation of an in-house LipL32 polymerase chain reaction for diagnosis of leptospirosis and its correlation with various serological diagnostic techniques.

Indian J Med Microbiol 2018 Jul-Sep;36(3):385-390

Department of Biotechnology, University of Mysore, Mysore, Karnataka, India.

Background: Leptospirosis is a zoonotic disease of ubiquitous distribution. During rainy seasons, in spring and summer and also during harvest times, the risk of leptospirosis increases as there are chances of frequent contact with infected rat population which is common in Karnataka as farming is a main source of income to the people here. There is a paucity of data regarding the prevalent serovars from Karnataka. Read More

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http://dx.doi.org/10.4103/ijmm.IJMM_17_355DOI Listing
February 2019

Seroprevalence and distribution of leptospirosis serovars among wet market workers in northeastern, Malaysia: a cross sectional study.

BMC Infect Dis 2018 Nov 14;18(1):569. Epub 2018 Nov 14.

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.

Background: Leptospirosis is a zoonotic disease associated with occupations which exposed workers to environments contaminated with urine of infected animals. The objective of this study was to determine the seroprevalence of leptospirosis among wet market workers in Kelantan.

Methods: A cross sectional study was conducted in two main wet markets in Kelantan and 232 wet market workers were randomly selected. Read More

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http://dx.doi.org/10.1186/s12879-018-3470-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236877PMC
November 2018
2 Reads

Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan.

Korean J Parasitol 2018 Oct 31;56(5):521-525. Epub 2018 Oct 31.

International Development Group, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.5.521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243181PMC
October 2018
21 Reads

Analysis of the spatial distribution of scientific publications regarding vector-borne diseases related to climate variability in South America.

Spat Spatiotemporal Epidemiol 2018 08 22;26:35-93. Epub 2018 May 22.

Centro Regional de Geomática (CEREGeo), Universidad Autónoma de Entre Ríos (UADER), Km 10,5, RP11, CP3100, Oro Verde, Entre Ríos, Argentina.

Most vector-borne diseases exhibit a distinct seasonal pattern, which clearly suggests that they are weather sensitive. Rainfall, temperature, and other climate variables affect in many ways both the vectors and the pathogens they transmit. Likewise, climate can be determinant in outbreaks incidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18775845173011
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http://dx.doi.org/10.1016/j.sste.2018.04.003DOI Listing
August 2018
13 Reads

Knowledge, Attitudes, Practices and Health Beliefs toward Leptospirosis among Urban and Rural Communities in Northeastern Malaysia.

Int J Environ Res Public Health 2018 11 1;15(11). Epub 2018 Nov 1.

Health Department of Federal Territory Kuala Lumpur and Putrajaya, Jalan Cenderasari, Kuala Lumpur 50590, Malaysia.

Background: Leptospirosis is a zoonotic disease with a worldwide distribution, especially in developing countries such as Malaysia. This study was designed to explore the knowledge, attitudes, beliefs and practices (KABP) toward leptospirosis among the communities in northeastern Malaysia and to determine the sociodemographic factors associated with the KABP toward leptospirosis. A cross-sectional study using a stratified sampling method was conducted among 214 individuals in four locales in northeastern Malaysia. Read More

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http://www.mdpi.com/1660-4601/15/11/2425
Publisher Site
http://dx.doi.org/10.3390/ijerph15112425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266327PMC
November 2018
18 Reads
2.063 Impact Factor

Leptospira spp. in Rodents and Shrews from Afghanistan.

J Wildl Dis 2019 Apr 30;55(2):477-481. Epub 2018 Oct 30.

3 Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald-Insel Riems, Germany.

Leptospirosis is an occupational risk for military personnel and many cases have been reported worldwide. Rodents are the most important maintenance hosts for Leptospira spp. and may infect both animals and humans. Read More

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http://dx.doi.org/10.7589/2018-05-122DOI Listing
April 2019
2 Reads

A 3-year retrospective analysis on the prevalence of antileptospiral antibodies among children in Chennai City, India.

J Med Microbiol 2018 Dec 29;67(12):1706-1710. Epub 2018 Oct 29.

1​Department of Experimental Medicine, The Tamil Nadu Dr M. G. R. Medical University, Guindy, Chennai - 600 032, India.

Purpose: Leptospirosis is a re-emerging infectious disease that has been reported from all over the world, including South India. Several studies have documented the prevalence of Leptospira in the general population. However, the data on leptospirosis in children were limited. Read More

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http://www.microbiologyresearch.org/content/journal/jmm/10.1
Publisher Site
http://dx.doi.org/10.1099/jmm.0.000825DOI Listing
December 2018
7 Reads

vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation.

EBioMedicine 2018 Nov 15;37:428-441. Epub 2018 Oct 15.

Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, PR China; Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, PR China. Electronic address:

Backgroud: Leptospira interrogans is the major causative agent of leptospirosis, a worldwide zoonotic disease. Hemorrhage is a typical pathological feature of leptospirosis. Binding of von Willebrand factor (vWF) to platelet glycoprotein-Ibα (GPIbα) is a crucial step in initiation of platelet aggregation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183045
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http://dx.doi.org/10.1016/j.ebiom.2018.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284457PMC
November 2018
15 Reads

Characterization of patients transported with extracorporeal respiratory and/or cardiovascular support in the State of São Paulo, Brazil.

Rev Bras Ter Intensiva 2018 Jul-Sept;30(3):317-326

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brasil.

Objective: To characterize the transport of severely ill patients with extracorporeal respiratory or cardiovascular support.

Methods: A series of 18 patients in the state of São Paulo, Brazil is described. All patients were consecutively evaluated by a multidisciplinary team at the hospital of origin. Read More

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http://dx.doi.org/10.5935/0103-507X.20180052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180471PMC
December 2018
2 Reads

Predictive risk mapping of an environmentally-driven infectious disease using spatial Bayesian networks: A case study of leptospirosis in Fiji.

PLoS Negl Trop Dis 2018 10 11;12(10):e0006857. Epub 2018 Oct 11.

Research School of Population Health, The Australian National University, Canberra, Australia.

Introduction: Leptospirosis is a zoonotic disease responsible for over 1 million severe cases and 60,000 deaths annually. The wide range of animal hosts and complex environmental drivers of transmission make targeted interventions challenging, particularly when restricted to regression-based analyses which have limited ability to deal with complexity. In Fiji, important environmental and socio-demographic factors include living in rural areas, poverty, and livestock exposure. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006857
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0006857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198991PMC
October 2018
4 Reads

Uncommon manifestation of leptospirosis: a diagnostic challenge.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Leptospirosis is a zoonotic disease commonly affecting the tropical countries. It may have protean clinical manifestations including hepatorenal dysfunction, myocarditis, pulmonary haemorrhage, meningitis, optic neuritis and rhabdomyolysis. Neurological manifestation of leptospirosis without the classical hepatorenal dysfunction is a rare entity. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22528
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http://dx.doi.org/10.1136/bcr-2018-225281DOI Listing
October 2018
3 Reads

Coinfections as an aetiology of acute undifferentiated febrile illness among adult patients in the sub-Himalayan region of north India.

J Vector Borne Dis 2018 Apr-Jun;55(2):130-136

Department of Medicine, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.

Background & Objectives: In India, certain geographic regions witness simultaneous outbreaks of two or more diseases like scrub typhus, dengue fever, malaria, leptospirosis and chikungunya during monsoon and post-monsoon period, sharing common indication of acute febrile illness. The objective of the present study was to assess the prevalence of coinfections among patients with acute undifferentiated fevers (AUF) admitted in a tertiary care hospital in the northern hilly state of Himachal Pradesh, India.

Methods: This was a hospital based open cohort study conducted over a period of two months (September and October) in 2016. Read More

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http://www.jvbd.org/text.asp?2018/55/2/130/242560
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http://dx.doi.org/10.4103/0972-9062.242560DOI Listing
December 2018
5 Reads

Haemolysin Sph2 of Leptospira interrogans induces cell apoptosis via intracellular reactive oxygen species elevation and mitochondrial membrane injury.

Cell Microbiol 2019 Jan 19;21(1):e12959. Epub 2018 Oct 19.

Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.

Leptospira interrogans causes widespread leptospirosis in humans and animals, with major symptoms of jaundice and haemorrhage. Sph2, a member of the sphingomyelinase haemolysins, is an important virulence factor for leptospire. In this study, the function and mechanism of Sph2 in the pathogenesis of leptospirosis were investigated to further understand the pathogenesis of leptospire. Read More

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http://dx.doi.org/10.1111/cmi.12959DOI Listing
January 2019
4 Reads

Dealing with leptospirosis in dogs.

Authors:
Kate Murphy

Vet Rec 2018 Sep;183(12):384-385

IDEXX Laboratories, Grange House, Sandbeck Way, Wetherby, West Yorkshire LS22 7DN.

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http://dx.doi.org/10.1136/vr.k4093DOI Listing
September 2018

Genetic diversity of Leptospira interrogans circulating isolates and vaccine strains in China from 1954-2014.

Hum Vaccin Immunother 2019 12;15(2):381-387. Epub 2018 Oct 12.

c Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products , National Institutes for Food and Drug Control , Beijing , People's Republic of China.

Leptospirosis is one of the most important but neglected, infectious tropical diseases worldwide. Leptospira interrogans is now recognized as a leading cause of the disease. Little is known of the genetic diversity and phylogenetic characteristics of L. Read More

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http://dx.doi.org/10.1080/21645515.2018.1528839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422446PMC
October 2018
4 Reads

An infection cocktail: malaria, dengue, chikungunya and Japanese encephalitis.

Authors:
Nishanth Dev

Trop Doct 2019 Jan 27;49(1):42-43. Epub 2018 Sep 27.

Assistant Professor, Department of Medicine, ESIC Medical College, Faridabad, Haryana, India.

Vector-borne diseases cause a significant burden on healthcare facilities. An increasing number of cases reported with multiple co-infections only add to the ordeal. The presence of co-infection may modify clinical and laboratory parameters significantly making diagnosis and treatment a challenge. Read More

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http://dx.doi.org/10.1177/0049475518801714DOI Listing
January 2019
8 Reads

Severe pulmonary haemorrhage syndrome in leptospirosis in a returning traveller.

Infection 2019 Feb 18;47(1):125-128. Epub 2018 Sep 18.

Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany.

Clinical presentation of leptospirosis ranges from asymptomatic infection to fulminant, life-threatening disease. Pulmonary involvement in terms of severe pulmonary haemorrhage syndrome (SPHS) has recently become a more frequently reported facet of leptospirosis and correlates with high mortality rates. It has not yet been described in returning German travellers. Read More

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http://dx.doi.org/10.1007/s15010-018-1220-7DOI Listing
February 2019
20 Reads

Development and evaluation of monoclonal antibody-based antigen capture enzyme-linked immunosorbent assay for the diagnosis of acute leptospirosis in humans.

J Immunol Methods 2018 Dec 12;463:134-136. Epub 2018 Sep 12.

Laboratory of Infectious Diseases, Department of Microbiology, Graduate School of Medicine, Hokkaido University, Japan.

Monoclonal antibody (MAb)-based ELISA was developed to detect leptospiral antigens from the plasma of febrile patients. The MAb reacts specifically with pathogenic leptospires and the assay possesses excellent diagnostic test parameters compared to PCR, indicating that this new ELISA is useful for the early diagnosis of leptospirosis with low operational cost. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00221759183028
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http://dx.doi.org/10.1016/j.jim.2018.09.006DOI Listing
December 2018
30 Reads

Detection of pathogenic Leptospira in ornamental water fountains from urban sites in Cali, Colombia.

Int J Environ Health Res 2019 Feb 14;29(1):107-115. Epub 2018 Sep 14.

b Department of Microbiology, School of Basic Sciences , Universidad del Valle , Cali , Colombia.

Leptospirosis is a disease endemic to both rural and urban areas of tropical countries and resource-poor communities. Little information is available on the presence of Leptospira spp. in urban water sources. Read More

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http://dx.doi.org/10.1080/09603123.2018.1519526DOI Listing
February 2019
15 Reads
1.513 Impact Factor

Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis.

PLoS Negl Trop Dis 2018 09 13;12(9):e0006694. Epub 2018 Sep 13.

Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay.

Leptospirosis is a neglected zoonosis with worldwide distribution. The causative agents are spirochete bacteria of the Leptospira genus, displaying huge diversity of serovars, the identity of which is critical for effective diagnosis and vaccination purposes. Among many other mammalian species, Leptospira infects cattle, eliciting acute signs in calves, and chronic disease in adult animals often leading to abortions. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136691PMC
September 2018
9 Reads

[Infectious diseases related to water in Peru].

Rev Peru Med Exp Salud Publica 2018 Apr-Jun;35(2):309-316

Centro Nacional de Salud Pública, Instituto Nacional de Salud. Lima, Perú.

The growth of the world population has increased the demand for water. On the other hand, climate change shows us that the water sources that were previously safe are not anymore. There are inequalities between urban and rural areas, thus 96% of the urban world population uses drinking water sources compared to 84% of the rural population, while 82% of the urban population versus 51% of the rural population use sanitation facilities. Read More

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https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/3761
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http://dx.doi.org/10.17843/rpmesp.2018.352.3761DOI Listing
March 2019
17 Reads

A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas.

Infect Dis Poverty 2018 Sep 3;7(1):87. Epub 2018 Sep 3.

University of Montreal Public Health Research Institute (IRSPUM), Montreal, Canada.

Background: Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings. There is a need to know what rapid diagnostic technologies are available, have been properly assessed, and are being implemented to improve control of these diseases in the urban context. This paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty. Read More

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http://dx.doi.org/10.1186/s40249-018-0474-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120097PMC
September 2018
22 Reads

Leptospirosis in pregnancy: A lesson in subtlety.

Malays J Pathol 2018 Aug;40(2):169-173

University Teknologi MARA, Faculty of Medicine, Centre for Diagnostic & Research Laboratories, Selangor, Malaysia.

Introduction: Leptospirosis is a zoonotic disease caused by spirochaete of the genus Leptospira. Human infection occurs after exposure to water or soil contaminated by urine from an infected animal. Most patients manifest as self-limited systemic illness. Read More

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August 2018
15 Reads

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins.

Cell Microbiol 2019 Feb 26;21(2):e12949. Epub 2018 Sep 26.

Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France.

Pathogenic Leptospira bacteria are the causative agents of leptospirosis, a zoonotic disease affecting animals and humans worldwide. These pathogenic species have the ability to rapidly cross host tissue barriers by a yet unknown mechanism. A comparative analysis of pathogens and saprophytes revealed a higher abundance of genes encoding proteins with leucine-rich repeat (LRR) domains in the genomes of pathogens. Read More

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http://doi.wiley.com/10.1111/cmi.12949
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http://dx.doi.org/10.1111/cmi.12949DOI Listing
February 2019
10 Reads

Fine-scale GPS tracking to quantify human movement patterns and exposure to leptospires in the urban slum environment.

PLoS Negl Trop Dis 2018 08 31;12(8):e0006752. Epub 2018 Aug 31.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.

Background: Human movement is likely an important risk factor for environmentally-transmitted pathogens. While epidemiologic studies have traditionally focused on household risk factors, individual movement data could provide critical additional information about risk of exposure to such pathogens. We conducted global positioning system (GPS) tracking of urban slum residents to quantify their fine-scale movement patterns and evaluate their exposures to environmental sources of leptospirosis transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143277PMC
August 2018
14 Reads