6,546 results match your criteria Leptospirosis in Humans


Detection and characterization of spp. in dogs diagnosed with kidney and/or liver disease in Selangor, Malaysia.

J Vet Diagn Invest 2021 Jun 19:10406387211024575. Epub 2021 Jun 19.

Departments of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Leptospirosis is a serious bacterial disease that affects both humans and animals. A wide range of symptoms have been described in humans; the disease in dogs is commonly associated with kidney and/or liver disease. In Malaysia, information about the common serovars infecting dogs is limited. Read More

View Article and Full-Text PDF

The epidemiology of bacterial zoonoses in pastoral and dairy cattle in Cameroon, Central Africa.

Zoonoses Public Health 2021 Jun 15. Epub 2021 Jun 15.

Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.

Previous work identified that bacterial zoonoses (Brucella species, Coxiella burnetii and Leptospira hardjo) were present in Cameroonian pastoral cattle. To assess the characteristics of this zoonotic risk, we analyse seroprevalence of each pathogen and the associated management, herd and environmental factors in Cameroonian pastoral and dairy cattle. Cross-sectional samples included pastoralist herds in the Northwest Region (NWR n = 750) and Vina Division (VD n = 748) and small holder dairy herds in the NWR (n = 60). Read More

View Article and Full-Text PDF

Leptospirosis as a neglected burden at human-cattle interface in Mid-Delta of Egypt.

J Infect Dev Ctries 2021 05 31;15(5):704-709. Epub 2021 May 31.

Animal Medicine Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Introduction: Leptospirosis is a neglected zoonosis in developing countries including Egypt where its burden is underestimated.

Methodology: A cross sectional study was carried out to estimate the seroprevalence and associated risk factors of Leptospira interrogans serovar Hardjo infection among cows and leptospirosis among human patients in Mid-Delta of Egypt.

Results: Out of 112 examined cows using ELISA, 3. Read More

View Article and Full-Text PDF

Human leptospirosis in the municipality of São Paulo, SP, Brazil: distribution and trend according to sociodemographic factors, 2007-2016.

Rev Bras Epidemiol 2021 7;24:e210034. Epub 2021 Jun 7.

Department of Epidemiology, School of Public Health, Universidade de São Paulo - São Paulo (SP), Brazil.

Objectives: This study aimed to describe the incidence and proportional lethality of human leptospirosis in the municipality of São Paulo, between 2007 and 2016, according to sociodemographic factors and characteristics of the disease, and to assess the temporal trends of incidence, according to age group and region of residence.

Methods: Proportional distributions of leptospirosis cases of residents in the municipality were built and regression models with a Binomial Negative response were adjusted.

Results: 2,201 cases of leptospirosis were registered, most of them being males (82%), aged between 20 to 59 years (64. Read More

View Article and Full-Text PDF

A rare case of posterior reversible encephalopathy syndrome in a patient with severe leptospirosis complicated with rhabdomyolysis and acute kidney injury; a case report.

BMC Infect Dis 2021 Jun 3;21(1):522. Epub 2021 Jun 3.

National Hospital of Sri Lanka, Colombo 08, Sri Lanka.

Background: Leptospirosis is a zoonotic spirochetal disease caused by Leptospira interrogans. The clinical presentation ranges from an asymptomatic state to a fatal multiorgan dysfunction. Neurological manifestations including aseptic meningitis, spinal cord and peripheral nerve involvement, cranial neuropathies and cerebellar syndrome are well recognized with varying frequencies among patients with this disease. Read More

View Article and Full-Text PDF

Leptospirosis in Ruminants in Yogyakarta, Indonesia: A Serological Survey with Mixed Methods to Identify Risk Factors.

Trop Med Infect Dis 2021 May 20;6(2). Epub 2021 May 20.

International Livestock Research Institute (ILRI), Hanoi 100000, Vietnam.

Leptospirosis is a zoonotic disease occurring worldwide with reproductive symptoms and production losses in livestock, while humans can suffer fatal renal failure. In Yogyakarta Special Province, Indonesia, there have been several outbreaks with high case fatality, demonstrating the public health importance, but there is limited understanding of the epidemiology. This study used an EcoHealth approach to ensure transdisciplinarity and community participation. Read More

View Article and Full-Text PDF

Leptospirosis in febrile patients with suspected diagnosis of dengue fever.

BMC Res Notes 2021 May 29;14(1):209. Epub 2021 May 29.

School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Objective: This study was carried out to determine the prevalence of leptospirosis among febrile patients with a suspicious clinical diagnosis of dengue fever in northern Peru.

Results: A total of 276 serum samples from patients with acute febrile illness (AFI) and suspected diagnosis for dengue virus (DENV) were analyzed. We identified an etiological agent in 121 (47. Read More

View Article and Full-Text PDF

Aseptic meningitis as the initial presentation of Leptospira borgpetersenii serovar Tarassovi: two case reports and a literature review.

BMC Infect Dis 2021 May 27;21(1):488. Epub 2021 May 27.

Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.

Background: Leptospirosis is a zoonotic illness caused by pathogenic spirochetes of the genus Leptospira. The disease spectrum ranges from a mild influenza-like presentation to a more serious Weil's syndrome. Leptospirosis rarely presents as a primary neurological syndrome. Read More

View Article and Full-Text PDF

Leptospirosis with pulmonary haemorrhage and multiple organ failure: a case report and literature review.

J Int Med Res 2021 May;49(5):3000605211019665

Department of Emergency, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China.

Pulmonary haemorrhage is an important complication of leptospirosis. We herein report an uncommon case of severe pulmonary haemorrhage and multiple organ failure caused by leptospirosis in a 49-year-old man who was previously healthy. He was a farm worker who was admitted to the hospital because of haemoptysis. Read More

View Article and Full-Text PDF

Effect of disinfection agents and quantification of potentially viable Leptospira in fresh water samples using a highly sensitive integrity-qPCR assay.

PLoS One 2021 26;16(5):e0251901. Epub 2021 May 26.

Eau de Paris, DRDQE, Ivry-Sur-Seine, France.

Leptospirosis is an emerging worldwide zoonotic disease, but the general biology of the causative agents is still poorly understood. Humans are an occasional host. The main risk factors are water-associated exposure during professional or recreational activities or during outbreaks in endemic areas. Read More

View Article and Full-Text PDF

[Floods and leptospirosis in Brazilian municipalities from 2003 to 2013: use of data mining techniques].

Cad Saude Publica 2021 14;37(5):e00100119. Epub 2021 May 14.

Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

Leptospirosis is related to problems with environmental sanitation, and the incidence tends to increase during flood periods. Considering issues related to climate change, floods can be expected to increase. Floods do not affect populations homogeneously, and communities with worse socioeconomic conditions tend to be impacted more heavily. Read More

View Article and Full-Text PDF

Molecular and serological epidemiology of Leptospira infection in cats in Okinawa Island, Japan.

Sci Rep 2021 May 14;11(1):10365. Epub 2021 May 14.

Department of Bacteriology I, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.

Leptospirosis is a zoonosis caused by pathogenic Leptospira spp. Cats have been reported to be infected with Leptospira spp. and shed the bacteria in the urine. Read More

View Article and Full-Text PDF

Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka.

Case Rep Infect Dis 2021 21;2021:5555613. Epub 2021 Apr 21.

National Hospital-Kandy, Kandy, Sri Lanka.

Hantaviruses are a large family of enveloped viruses with two medically important families Cricetidae and Muridae which are known to cause rodent-borne diseases worldwide. Some strains cause clinical syndromes with multiorgan involvement in humans such as hantavirus haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which is also known as hantavirus pulmonary syndrome. Clinical differentiation of this infection from other endemic infections in Sri Lanka such as leptospirosis and rickettsial infections is extremely difficult due to overlapping clinical and epidemiologic features such as exposure to rodents and farming. Read More

View Article and Full-Text PDF

Outer Membrane Protein-Based Nanohybrid Sensor for the Diagnosis of Leptospirosis.

Sensors (Basel) 2021 Apr 6;21(7). Epub 2021 Apr 6.

School of Bioengineering and Food Technology, Shoolini University, Solan 173229, HP, India.

Leptospirosis is an underestimated tropical disease caused by the pathogenic species and responsible for several serious health problems. Here, we aimed to develop an ultrasensitive DNA biosensor for the rapid and on-site detection of the gene of using a gold nanoparticle-carbon nanofiber composite (AuN/CNF)-based screen-printed electrode. Cyclic voltammetry and electrochemical impedance were performed for electrochemical analysis. Read More

View Article and Full-Text PDF

Seroprevalence of spp. in Horses in Israel.

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.

Leptospirosis has been reported in both humans and animals in Israel but has not been reported in horses. In 2018, an outbreak of spp. serogroup Pomona was reported in humans and cattle in Israel. Read More

View Article and Full-Text PDF

First detection of antibodies against Leptospira among free-ranging neotropical non-human primates in the Peruvian Amazon lowland rainforest.

Transbound Emerg Dis 2021 Apr 25. Epub 2021 Apr 25.

Infectious Diseases, Washington University in St Louis School of Medicine, Saint Louis, MO, USA.

Leptospirosis is a bacterial zoonotic disease with multiple serogroups that infects wildlife and humans alike. Several studies have detected the presence of leptospiral antibodies in captive Neotropical primates, suggesting that they are asymptomatic carriers. However, the presence of antibodies in free-ranging primates and their potential role as reservoirs for this pathogen is not known. Read More

View Article and Full-Text PDF

hTLR2 interacting peptides of pathogenic leptospiral outer membrane proteins.

Microb Pathog 2021 Jun 17;155:104895. Epub 2021 Apr 17.

Medical Microbiology Laboratory (MML), Department of Microbiology, Center for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli, 620024, India. Electronic address:

To adapt into the host system from moist environment Leptospira alter their gene expression by inducing differential expression of the genes encoding virulence factors. Knowledge about the molecular pathogenesis and virulent evolution remains limited to Leptospira. The pathogenic organism sense the environmental changes mainly through their outer membrane proteins that in-turn activates the signal transduction pathways to overcome the stress to adaptation into host system and to evade immunity. Read More

View Article and Full-Text PDF

Serological and molecular study of Leptospira in pediatric patients at a tertiary care centre of northern India.

Indian J Med Microbiol 2021 Apr 12;39(2):245-248. Epub 2021 Apr 12.

Department of Centre for Integrative Medicine & Research, AIIMS, New Delhi, India. Electronic address:

Leptospirosis is considered as one of the most neglected zoonotic tropical diseases. Animals and humans acquire this infection through direct contact with contaminated urine or body fluids of infected animals. This prospective study was undertaken to know the proportion of leptospirosis in pediatric patients presented with acute febrile illness at the Post Graduate Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh. Read More

View Article and Full-Text PDF

[Leptospirosis in pediatrics, a diagnosis to be considered].

Rev Chilena Infectol 2020 Dec;37(6):728-738

Universidad CES y Universidad Pontificia Bolivariana, Medellín, Colombia.

Human leptospirosis is an important cause of acute febrile disease that most frequently affects tropical areas. Its main reserve is rodents, so the infection is limited by factors of poverty, health deficit, recreational and work activities that favor contact with the urine of infected animals, contaminated water or soil. Leptospira spp infections have a non-specific presentation, ranging from asymptomatic to multisystem compromise with high mortality; being the clinical suspicion and the presence of risk factors the initial variables for the diagnosis of the disease. Read More

View Article and Full-Text PDF
December 2020

Leptospirosis prevalence and risk factors in India: Evidence gap maps.

Trop Doct 2021 Apr 9:494755211005203. Epub 2021 Apr 9.

The George Institute for Global Health, New Delhi, India.

Leptospirosis is a zoonotic disease of public health importance in India. A country-level evidence gap map was developed to identify gaps on epidemiology of leptospirosis. It is the first such on leptospirosis globally and on any single disease condition in India. Read More

View Article and Full-Text PDF

Distinct transcriptional profiles of Leptospira borgpetersenii serovar Hardjo strains JB197 and HB203 cultured at different temperatures.

PLoS Negl Trop Dis 2021 Apr 7;15(4):e0009320. Epub 2021 Apr 7.

Infectious Bacterial Disease Research Unit, USDA Agriculture Research Service, National Animal Disease Center, Ames, Iowa, United States of America.

Background: Leptospirosis is a zoonotic, bacterial disease, posing significant health risks to humans, livestock, and companion animals around the world. Symptoms range from asymptomatic to multi-organ failure in severe cases. Complex species-specific interactions exist between animal hosts and the infecting species, serovar, and strain of pathogen. Read More

View Article and Full-Text PDF

infection in people in the city of Durango, Mexico: a cross sectional study.

J Int Med Res 2021 Apr;49(4):3000605211004020

Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Durango, Mexico.

Objective: To determine the seroprevalence of immunoglobulin (Ig)G and IgM antibodies and its association with the characteristics of the study population from the northern Mexican city of Durango, Mexico.

Methods: Through a cross-sectional study design, inhabitants of Durango City, Mexico were surveyed between June 2018 and November 2018. Serum samples from the subjects were analysed for anti- IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Read More

View Article and Full-Text PDF

Seroprevalence and Distribution of Leptospiral Serovars in Livestock (cattle, Goats, and Sheep) in Flood-prone Kelantan, Malaysia.

J Vet Res 2021 Mar 29;65(1):53-58. Epub 2020 Dec 29.

Department of Veterinary Pathology and Microbiology, 43400, Serdang, Selangor, Malaysia.

Introduction: Leptospirosis is a bacterial disease that affects both humans and animals, the occurrence of which increases markedly during and after heavy rainfall and flooding. The aim of this study was to determine the serological prevalence of leptospiral infection in livestock after a voluminous flood in 10 districts of the Malaysian state of Kelantan.

Material And Methods: In December 2014, Kelantan was hit by an extensive flood. Read More

View Article and Full-Text PDF

Blood Levels of Galectin-9, an Immuno-Regulating Molecule, Reflect the Severity for the Acute and Chronic Infectious Diseases.

Biomolecules 2021 03 15;11(3). Epub 2021 Mar 15.

Department of Health Science and Social Welfare, Kibi International University, Takahashi 716-8508, Japan.

Galectin-9 (Gal-9) is a β-galactoside-binding lectin capable of promoting or suppressing the progression of infectious diseases. This protein is susceptible to cleavage of its linker-peptides by several proteases, and the resulting cleaved forms, N-terminal carbohydrate recognition domain (CRD) and C-terminal CRD, bind to various glycans. It has been suggested that full-length (FL)-Gal-9 and the truncated (Tr)-Gal-9s could exert different functions from one another via their different glycan-binding activities. Read More

View Article and Full-Text PDF

Persistence of Serovar Hardjo in Refrigerated Raw Milk: A Transmission Risk of Leptospirosis to Humans.

Pathogens 2021 Mar 3;10(3). Epub 2021 Mar 3.

Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.

serovar Hardjo (LH) is an important infectious agent of reproduction pathologies and lactation decline in cattle, with a possible zoonotic role. To figure out the potential zoonotic risk for human raw-milk consumption, the present study aims at assessing the persistence and viability of LH in refrigerated raw milk over a 10-day period, which is set as the maximum time range for raw-milk domestic consumption. A negative sample of fresh raw milk was contaminated with an LH strain (2 × 10 Leptospires/mL) and analyzed by a rrs (16S) gene targeting real-time PCR (rPCR) protocol for LH DNA at days 1, 2, 3, 6, 7, 9, and 10. Read More

View Article and Full-Text PDF

Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Infection in the First Free Living Wolf ( Linnaeus, 1758) Found Dead in the Friuli Venezia Giulia Region.

Int J Environ Res Public Health 2021 03 3;18(5). Epub 2021 Mar 3.

Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università, 35020 Legnaro, Italy.

Leptospirosis is a worldwide-spread zoonosis causing disease and death in dogs and in humans. A Leptospiral infection has been recorded in several wild carnivore species in Europe, but tissue pathological changes were not commonly described. The Grey wolf () has been expanding its distribution range in north-eastern Italy during the last decade. Read More

View Article and Full-Text PDF

Exposure to spp. and Associated Risk Factors in the Human, Cattle and Dog Populations in Bhutan.

Pathogens 2021 Mar 6;10(3). Epub 2021 Mar 6.

Department of Pathology and Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Thimphu 11001, Bhutan.

Leptospirosis is a neglected worldwide zoonotic bacterial disease with a high prevalence in subtropical and tropical countries. The prevalence of spp. in humans, cattle and dogs is unknown in Bhutan. Read More

View Article and Full-Text PDF

Seroprevalence in Colombian Dairy Herds.

Animals (Basel) 2021 Mar 11;11(3). Epub 2021 Mar 11.

Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, Italy.

Leptospirosis in cattle has important economic effects on the infected farms. Moreover, livestock farming is considered a major occupational risk factor for the transmission of infection to humans. A survey was performed to determine the overall and within-herd seroprevalence and mapping of different serovars in dairy cattle from farms located in some municipalities of the Colombian department of Boyacá. Read More

View Article and Full-Text PDF

GroEL protein of the Leptospira spp. interacts with host proteins and induces cytokines secretion on macrophages.

BMC Microbiol 2021 Mar 31;21(1):99. Epub 2021 Mar 31.

Laboratory of Bacteriology, Butantan Institute, São Paulo, Brazil.

Background: Leptospirosis is a zoonotic disease caused by infection with spirochetes from Leptospira genus. It has been classified into at least 17 pathogenic species, with more than 250 serologic variants. This wide distribution may be a result of leptospiral ability to colonize the renal tubules of mammalian hosts, including humans, wildlife, and many domesticated animals. Read More

View Article and Full-Text PDF

Multisystem Inflammatory Syndrome in a Child with Scrub Typhus and Macrophage Activation Syndrome.

J Trop Pediatr 2021 01;67(1)

Department of Pediatrics and Neonatology, Max Super Speciality Hospital, Mohali, Punjab, India.

Lay Summary: Clinical and laboratory parameters of multisystem inflammatory syndrome in children (MIS-C) mimic Kawasaki disease (KD). KD has been described in association with dengue, scrub typhus and leptospirosis. However, MIS-C with concomitant infection has rarely been reported in literature. Read More

View Article and Full-Text PDF
January 2021