6,781 results match your criteria Leptospirosis in Humans


Diagnosis of Human Leptospirosis: Comparison of Microscopic Agglutination Test with Recombinant LigA/B Antigen-Based In-House IgM Dot ELISA Dipstick Test and Latex Agglutination Test Using Bayesian Latent Class Model and MAT as Gold Standard.

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Institute of Chemistry, Academia Sinica, Taipei 115024, Taiwan.

Leptospirosis is a spirochaetal infection that possesses a broad host range affecting almost all mammals. In the present study, the microscopic agglutination test (MAT) was compared with recombinant LigA/B antigen-based point-of-care diagnostics such as the in-house IgM dot ELISA dipstick test (IgM- DEDT) and the latex agglutination test (LAT) for the serodiagnosis of human leptospirosis. The comparison of the MAT with these two point-of-care diagnostics was performed using the MAT as the gold standard test and using Bayesian latent class modelling (BLCM), which considers all diagnostic tests as imperfect. Read More

View Article and Full-Text PDF

Original Leptospira spp. in island native terrestrial mammals: a case study in Pteropus spp. bats of New Caledonia.

Transbound Emerg Dis 2022 Jun 22. Epub 2022 Jun 22.

Institut Pasteur in New Caledonia, Leptospirosis Research and Expertise Unit.

Leptospirosis is a bacterial zoonosis that occurs in tropical and subtropical regions worldwide. Chiroptera are known to be a formidable reservoir of zoonotic pathogens, including leptospires. The epidemiology of leptospirosis in bats in the Pacific Islands is poorly known, both in terms of prevalence and in terms of the bacterial strains involved. Read More

View Article and Full-Text PDF

Estimating the duration of antibody positivity and likely time of Leptospira infection using data from a cross-sectional serological study in Fiji.

PLoS Negl Trop Dis 2022 06 13;16(6):e0010506. Epub 2022 Jun 13.

Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Leptospirosis is a zoonotic disease prevalent throughout the world, but with particularly high burden in Oceania (including the Pacific Island Countries and Territories). Leptospirosis is endemic in Fiji, with outbreaks often occurring following heavy rainfall and flooding. As a result of non-specific clinical manifestation and diagnostic challenges, cases are often misdiagnosed or under-ascertained. Read More

View Article and Full-Text PDF

Zoonotic pathogens and diseases detected in Vietnam, 2020-2021.

One Health 2022 Jun 13;14:100398. Epub 2022 May 13.

Food and Agriculture Organization of the United Nations (FAO), Country Office for Vietnam, Hanoi, Vietnam.

Vietnam has been identified as a country at high-risk for emergence and re-emergence of zoonotic diseases. The government of Vietnam recognized five priority zoonoses, including highly pathogenic avian influenza, rabies, leptospirosis, anthrax, and , and established a framework for One Health investigation and response to these diseases. From July 2020 to February 2021, quantitative data of zoonoses were collected from an online survey in 61 of 63 provinces based on either clinical diagnosis or laboratory confirmation. Read More

View Article and Full-Text PDF

Factors affecting preventive behavior against leptospirosis among the population at risk in Si Sa Ket, Thailand.

One Health 2022 Jun 13;14:100399. Epub 2022 May 13.

Tropical and Parasitic Diseases Research Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand.

Leptospirosis is a major public health problem in Si Sa Ket, Thailand. Humans can become infected direct contact with the urine of infected animal reservoir hosts or by indirect contact with contaminated soil and water in the environment. This study examined the factors affecting preventive behavior against leptospirosis among the population at risk in Si Sa Ket, Thailand. Read More

View Article and Full-Text PDF

Comparison of the Serion IgM ELISA and Microscopic Agglutination Test for diagnosis of Leptospira spp. infections in sera from different geographical origins and estimation of Leptospira seroprevalence in the Wiwa indigenous population from Colombia.

PLoS Negl Trop Dis 2022 06 6;16(6):e0009876. Epub 2022 Jun 6.

Medical Mission Institute, Wuerzburg, Germany.

Leptospirosis is among the most important zoonotic diseases in (sub-)tropical countries. The research objective was to evaluate the accuracy of the Serion IgM ELISA EST125M against the Microscopic Agglutination Test (MAT = imperfect reference test); to assess its ability to diagnose acute leptospirosis infections and to detect previous exposure to leptospires in an endemic setting. In addition, to estimate the overall Leptospira spp. Read More

View Article and Full-Text PDF

Pathogenic Leptospira Species Are Widely Disseminated among Wild Rodents in Urban Areas of Guangzhou, Southern China.

Microorganisms 2022 Apr 22;10(5). Epub 2022 Apr 22.

Department of Parasitic Disease and Endemic Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.

Leptospirosis is a neglected zoonotic disease with global importance caused by pathogenic . Rodents are considered the most significant reservoirs for both human and animal infection. Historically, Guangzhou has been an endemic region of human leptospirosis. Read More

View Article and Full-Text PDF

A free customizable tool for easy integration of microfluidics and smartphones.

Sci Rep 2022 May 27;12(1):8969. Epub 2022 May 27.

Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET), Colectora RN 168, S3000GLN, Santa Fe, Argentina.

The integration of smartphones and microfluidics is nowadays the best possible route to achieve effective point-of-need testing (PONT), a concept increasingly demanded in the fields of human health, agriculture, food safety, and environmental monitoring. Nevertheless, efforts are still required to integrally seize all the advantages of smartphones, as well as to share the developments in easily adoptable formats. For this purpose, here we present the free platform appuente that was designed for the easy integration of microfluidic chips, smartphones, and the cloud. Read More

View Article and Full-Text PDF

A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines.

PLoS Negl Trop Dis 2022 05 25;16(5):e0010414. Epub 2022 May 25.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.

Community-acquired bacterial bloodstream infections are caused by diverse pathogens with changing antimicrobial-resistance patterns. In low-middle income countries in Southeast Asia, where dengue fever is endemic and a leading cause of fever, limited information is available about bacterial bloodstream infections due to challenges of implementing a blood culture service. This study describes bacterial bloodstream pathogens and antimicrobial-resistance patterns in Metro Manila, the Philippines. Read More

View Article and Full-Text PDF

Prevalence of leptospirosis among patients attending renal and general outpatient clinics in Mulago Hospital, Kampala, Uganda.

Sci Rep 2022 May 19;12(1):8391. Epub 2022 May 19.

College of Veterinary Medicine, Animal Resources & Biosecurity (COVAB), Makerere University, Kampala, Uganda.

In this study, we sought to establish the prevalence of leptospirosis among renal patients and general outpatients attending Mulago National Referral Hospital, Uganda. A total of 254 patients were recruited, their blood samples collected and interviewer-administered semi-structured questionnaires provided between July and October 2018. These questionnaires captured data on sociodemographic characteristics and symptoms of leptospirosis disease. Read More

View Article and Full-Text PDF

Diverse lineages of pathogenic Leptospira species are widespread in the environment in Puerto Rico, USA.

PLoS Negl Trop Dis 2022 05 18;16(5):e0009959. Epub 2022 May 18.

The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.

Background: Leptospirosis, caused by Leptospira bacteria, is a common zoonosis worldwide, especially in the tropics. Reservoir species and risk factors have been identified but surveys for environmental sources are rare. Furthermore, understanding of environmental Leptospira containing virulence associated genes and possibly capable of causing disease is incomplete, which may convolute leptospirosis diagnosis, prevention, and epidemiology. Read More

View Article and Full-Text PDF

Leptospirosis: Morbidity, mortality, and spatial distribution of hospitalized cases in Ecuador. A nationwide study 2000-2020.

PLoS Negl Trop Dis 2022 05 12;16(5):e0010430. Epub 2022 May 12.

Instituto Nacional de Investigación en Salud Pública (INSPI), Quito, Ecuador.

Background: In Ecuador, leptospirosis surveillance involves a mandatory notification of all cases and a hospitalization for severe illness. Morbidity and mortality are, nevertheless, underestimated and contribute directly to the status of leptospirosis as a neglected disease. Leptospira spp. Read More

View Article and Full-Text PDF

Leptospiral infection: a serosurvey in urban and rural communities in Olavarría county, Argentina.

J Infect Dev Ctries 2022 04 30;16(4):608-615. Epub 2022 Apr 30.

Department of Rural Zoonoses, Provincial Bureau of Public Health Medicine, Ministry of Health, Buenos Aires Province, Azul, Argentina.

Introduction: Leptospirosis is a neglected zoonotic disease, affecting mainly poor and vulnerable populations.

Methodology: A cross sectional-study was carried out in 557 subjects from Olavarría county (Argentina) to estimate the seroprevalence of leptospirosis and the factors associated with seropositivity. A survey was carried out to obtain clinical and epidemiological data. Read More

View Article and Full-Text PDF

Endemic Thoracic Infections in Sub-Saharan Africa.

Radiol Clin North Am 2022 May;60(3):461-479

Alliar Group, Rua Ernesto Nazaré, 389 - Alto de Pinheiros, São Paulo, São Paulo 05462-000, Brazil.

Although many of the thoracic infections endemic to Africa are also present around the world, this article focuses on entities that are emerging or disproportionately affect populations living in sub-Saharan Africa. Important emerging or reemerging viral and bacterial diseases that commonly affect the lung include dengue fever, plague, leptospirosis, and rickettsioses. Most parasitic infections endemic to Africa can also manifest within the thorax, including malaria, amebiasis, hydatid disease, schistosomiasis, paragonimiasis, ascariasis, strongyloidiasis and cysticercosis. Read More

View Article and Full-Text PDF

Some like it hot, some like it cold; proteome comparison of Leptospira borgpetersenii serovar Hardjo strains propagated at different temperatures.

J Proteomics 2022 Jun 6;262:104602. Epub 2022 May 6.

Infectious Bacterial Disease Research Unit, USDA Agriculture Research Service, National Animal Disease Center, Ames, IA, USA. Electronic address:

Leptospirosis is a global zoonotic disease affecting humans and livestock species. Bacterin vaccines lack cross protection between serogroups, and include multiple serovars propagated at 29 °C. Recent work demonstrated substantial variation in the transcriptome of identical species and serovars of Leptospira. Read More

View Article and Full-Text PDF

[Characterization and temporal evolution of mortality due to zoonoses under mandatory declaration, between the years 1997 and 2018].

Rev Chilena Infectol 2021 10;38(5):667-677

Instituto de Salud Poblacional, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Background: Zoonoses are diseases transmitted from an animal host to humans or vice versa. In Chile, the zoonoses of mandatory notification are brucellosis, anthrax, trichinosis, hydatidosis, leptospirosis, dengue, Chagas disease, hantavirosis and rabies.

Aim: To assess the trend and characterize the mortality from zoonoses of mandatory notification in Chile between 1997-2018. Read More

View Article and Full-Text PDF
October 2021

[Severe paediatric leptospirosis caused by a pet rat].

Ned Tijdschr Geneeskd 2022 03 31;166. Epub 2022 Mar 31.

Alrijne Ziekenhuis, Leiderdorp: Afd. Neurologie.

Background: Leptospirosis is a bacterial infection which may cause multiple non-specific symptoms. Transmission of the disease can occur via rats or surface water infected by rats. The Netherlands have seen a record number of cases of leptospirosis in 2019. Read More

View Article and Full-Text PDF

Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis.

BMC Med 2022 05 2;20(1):144. Epub 2022 May 2.

Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Background: Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequencies and diagnostic predictors of the ubiquitous priority (i.e. Read More

View Article and Full-Text PDF

[Leptospirosis: A growing health threat to fish farming and recreational activities].

Ann Pharm Fr 2022 Apr 26. Epub 2022 Apr 26.

Sciences biologiques appliquées à la santé humaine, académie nationale de Pharmacie, France.

Leptospirosis is a cosmopolitan infectious disease caused by the bacteria Leptospirainterrogans, which is worldwide increasing as the result of climate changes favoring the reproduction of asymptomatic reservoir rodents and also flooding that brings mammals and humans into contact with contaminated water. This disease affects many mammals among wild, domestic or farmed animals. In humans, it is manifested through frustrated to severe forms that can lead to liver and kidney failure and death in about one in ten severe cases. Read More

View Article and Full-Text PDF

An outbreak of leptospirosis associated with cattle workers during the wet season, in the Northern Territory of Australia, 2021.

Commun Dis Intell (2018) 2022 Apr 26;46. Epub 2022 Apr 26.

Menzies School of Health Research, Darwin, Northern Territory, Australia.

Abstract: An outbreak of leptospirosis occurred in the Top End of the Northern Territory, Australia, during the wet season in early 2021. There were 14 outbreak cases; most were male (12/14; 86%) and non-Indigenous (13/14; 93%) with a median age of 22 years (range 19-52 years). We conducted a descriptive case series to investigate the outbreak. Read More

View Article and Full-Text PDF

Isolation of Serovar Canicola in a Vaccinated Dog without Clinical Symptoms.

Pathogens 2022 Mar 27;11(4). Epub 2022 Mar 27.

Istituto Zooprofilattico Sperimentale "G. Pegreffi" della Sardegna, Via Duca degli Abruzzi 8, 07100 Sassari, Italy.

More than one million cases of leptospirosis occur across the globe annually, resulting in about 59,000 deaths. Dogs are one of the most important reservoirs of species and play an important role in transmitting the pathogen to humans. Many of these infections are controlled by routine vaccination that has reduced the possible reintroduction of leptospiral serovars into the human population. Read More

View Article and Full-Text PDF

Role of Diagnostics in Epidemiology, Management, Surveillance, and Control of Leptospirosis.

Pathogens 2022 Mar 24;11(4). Epub 2022 Mar 24.

Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.

A One Health approach to the epidemiology, management, surveillance, and control of leptospirosis relies on accessible and accurate diagnostics that can be applied to humans and companion animals and livestock. Diagnosis should be multifaceted and take into account exposure risk, clinical presentation, and multiple direct and/or indirect diagnostic approaches. Methods of direct detection of spp. Read More

View Article and Full-Text PDF

and Leptospirosis: New Systems Science Insights on Proteome, Posttranslational Modifications, and Pathogen-Host Interaction.

OMICS 2022 May 19;26(5):280-289. Epub 2022 Apr 19.

Department of Biochemistry, ICMR-Regional Medical Research Centre, Port Blair, India.

Leptospirosis is one of the most important zoonotic diseases for planetary health. It is caused by spp., which poses a formidable challenge in both rural and urban geographies. Read More

View Article and Full-Text PDF

[Incidence of leptospirosis in Fujian province, 2015-2020].

Zhonghua Liu Xing Bing Xue Za Zhi 2022 Apr;43(4):548-553

Fujian Provincial Center for Disease Control and Prevention/Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou 350012, China College of Public Health, Fujian Medical University, Fuzhou 350122, China.

To analyze the incidence of leptospirosis in Fujian province from 2015 to 2020 and provide the scientific evidences for the risk assessment, prevention and control of leptospirosis. The incidence data of leptospirosis in Fujian during 2015-2020 were collected from China Information System for Disease Control and Prevention for a descriptive analysis, and software ArcGIS 10.3. Read More

View Article and Full-Text PDF

Predictors of Outcome in Acute Respiratory Distress Syndrome in Acute Febrile Illness in Medical Intensive Care Unit.

J Assoc Physicians India 2022 Mar;70(3):11-12

Professor and Head, Department of Medicine, Lokmanya Tilak Municipal General Hospital and Medical College, Mumbai, Maharashtra.

Aims: Acute Respiratory Distress Syndrome (ARDS) is a known complication of acute febrile illness (AFI). The in-hospital mortality rate of ARDS is between 35-44%. Our study aimed to identify the different parameters that could be used to detect patients at higher risk of poor outcome in AFI complicated by ARDS. Read More

View Article and Full-Text PDF

ErpY-like Lipoprotein of Outsmarts Host Complement Regulation by Acquiring Complement Regulators, Activating Alternative Pathways, and Intervening in the Membrane Attack Complex.

ACS Infect Dis 2022 05 14;8(5):982-997. Epub 2022 Apr 14.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.

The survival of pathogenic in the host depends on its proficiency to circumvent the immune response. These pathogens evade the complement system in serum by enticing and amassing the serum complement regulators onto their surface. ErpY-like lipoprotein, a surface-exposed protein of spp. Read More

View Article and Full-Text PDF

Case Report: Lyme Borreliosis and Pregnancy - Our Experience.

Front Med (Lausanne) 2022 28;9:816868. Epub 2022 Mar 28.

Department of Medical Sciences, University of Trieste, Trieste, Italy.

Lyme Borreliosis (LB) is an infection transmitted by sp. ticks. Its early manifestation includes erythema migrans rash. Read More

View Article and Full-Text PDF

Characteristics of human leptospirosis in three different geographical and climatic zones of Vietnam: a hospital-based study.

Int J Infect Dis 2022 Jul 10;120:113-120. Epub 2022 Apr 10.

National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam.

Background: To our knowledge, this study is the first report on the seroprevalence of human leptospirosis and its epidemiological profile in 3 different geographical and climatic zones of Vietnam.

Methodology: A hospital-based surveillance in 11 public hospitals in 3 provinces in Vietnam enrolled 3,815 patients with suspected leptospirosis. Two consecutive enzyme-linked immunosorbent assay IgM and a single microscopic aggregation test were applied at a 1:100 to 1:800 dilution for probable or confirmed cases. Read More

View Article and Full-Text PDF

Rainfall and other meteorological factors as drivers of urban transmission of leptospirosis.

PLoS Negl Trop Dis 2022 04 11;16(4):e0007507. Epub 2022 Apr 11.

Instituto de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Brazil.

Background: Leptospirosis is an important public health problem affecting vulnerable urban slum populations in developing country settings. However, the complex interaction of meteorological factors driving the temporal trends of leptospirosis remain incompletely understood.

Methods And Findings: From March 1996-March 2010, we investigated the association between the weekly incidence of leptospirosis and meteorological anomalies in the city of Salvador, Brazil by using a dynamic generalized linear model that accounted for time lags, overall trend, and seasonal variation. Read More

View Article and Full-Text PDF

Unraveling the invisible leptospirosis in mainland Southeast Asia and its fate under climate change.

Sci Total Environ 2022 Aug 4;832:155018. Epub 2022 Apr 4.

ESPACE-DEV, IRD, Univ Montpellier, Univ. Antilles, Univ Guyane, Univ Réunion, 5 Preah Monivong Blvd, Phnom Penh 12201, Cambodia.

Leptospirosis is a neglected waterborne zoonosis of growing concern in tropical and low-income regions. Endemic in Southeast Asia, its distribution and environmental factors such as climate controlling its dynamics remain poorly documented. In this paper, we investigate for the first time the current and future leptospirosis burden at a local scale in mainland Southeast Asia. Read More

View Article and Full-Text PDF