9,524 results match your criteria Leptospirosis in Humans


[Biological risk in agriculture and construction workplaces: a survey on perception, knowledge and prevention measures.]

G Ital Med Lav Ergon 2018 Dec;40(4):195-202

Cattedra di Igiene, Dipartimento di Medicina e Scienze per la Salute "Vincenzo Tiberio", Università degli Studi del Molise.

Objectives: Despite the potential presence in many workplaces, biological risk is little known and largely underestimated, except in healthcare environments. Objectives: To evaluate perception, knowledge and behaviors adopted for protection and prevention of biological risk, related also to the occupational activity, among construction and agricultural workers.

Methods: Workers were recruited at farms and construction companies of Molise Region, Central Italy, which were visited within the surveillance activities planned by local institutions. Read More

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December 2018

The monocytosis during human leptospirosis is associated with modest immune cell activation states.

Med Microbiol Immunol 2018 Dec 12. Epub 2018 Dec 12.

Université de La Réunion, CNRS 9192, INSERM U1187, IRD 249, UMR PIMIT, CHU de La Réunion, Unité Mixte Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion, France.

Leptospirosis is a life-threatening zoonotic disease and it has been hypothesized that the innate immune system fails to control the infection through ill-characterized mechanisms. The aim of this observational study was to better evaluate the activation processes of monocytes at the early stage of the disease. Blood samples were taken from healthy donors (n = 37) and patients hospitalized for either non-severe (n = 25) or severe (n = 32) leptospirosis. Read More

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December 2018

Data and tools to integrate climate and environmental information into public health.

Infect Dis Poverty 2018 Nov 29;7(1):126. Epub 2018 Nov 29.

The International Research Institute for Climate and Society, The Earth Institute, Columbia University, 61 Route 9W, Lamont-Doherty, Palisades, NY, 10964, USA.

Background: During the last 30 years, the development of geographical information systems and satellites for Earth observation has made important progress in the monitoring of the weather, climate, environmental and anthropogenic factors that influence the reduction or the reemergence of vector-borne diseases. Analyses resulting from the combination of geographical information systems (GIS) and remote sensing have improved knowledge of climatic, environmental, and biodiversity factors influencing vector-borne diseases (VBDs) such as malaria, visceral leishmaniasis, dengue, Rift Valley fever, schistosomiasis, Chagas disease and leptospirosis. These knowledge and products developed using remotely sensed data helped and continue to help decision makers to better allocate limited resources in the fight against VBDs. Read More

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November 2018

Leptospira species promote a pro-inflammatory phenotype in human neutrophils.

Cell Microbiol 2018 Dec 10:e12990. Epub 2018 Dec 10.

Laboratory of Animal Viruses, Institute of Biotechnology and Molecular Biology, CONICET-UNLP, La Plata, Argentina.

Leptospirosis is a global zoonosis caused by pathogenic Leptospira. Neutrophils are key cells against bacterial pathogens but can also contribute to tissue damage. Since the information regarding the role of human neutrophils in leptospirosis is scant, we comparatively analyzed the human neutrophil's response to saprophytic Leptospira biflexa serovar Patoc (Patoc) and the pathogenic Leptospira interrogans serovar Copenhageni (LIC). Read More

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December 2018

[Prevalence of dengue and leptospira in febrile patients of the general hospital of specialities in Mexico].

Rev Chilena Infectol 2018 ;35(3):332-333

Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campeche, México.

Among the infectious diseases characterized by a febrile picture are: dengue, leptospirosis, rickettsiosis and salmonellosis, among others. The objective of this study was to identify IgM antibodies against dengue and Leptospira in febrile patientes. The seropositivity for IgM antibodies to dengue was 34%; 26. Read More

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January 2018
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Complete Genome Sequences of Three Leptospira mayottensis Strains from Tenrecs That Are Endemic in the Malagasy Region.

Microbiol Resour Announc 2018 Oct 18;7(15). Epub 2018 Oct 18.

Unité Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Université de La Réunion, INSERM 1187, CNRS 9192, IRD 249, Plateforme de recherche CYROI, Sainte-Clotilde, La Réunion, France.

Leptospirosis is a zoonosis caused by Leptospira, a diversified genus containing more than 10 pathogenic species. Tenrecs are small terrestrial mammals endemic in the Malagasy region and are known to be reservoirs of the recently described species Leptospira mayottensis. We report the complete genome sequences of three L. Read More

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October 2018

Leptospirosis presenting as severe cardiogenic shock: A case report.

J Intensive Care Soc 2018 Nov 29;19(4):351-353. Epub 2018 Jan 29.

Adult Intensive Care Unit, Royal Brompton Hospital, London, UK.

Background: Leptospirosis is a rare infectious illness caused by the Spirochaete Leptospira. It has a wide-varying spectrum of presentation. We present a rare case of severe cardiogenic shock secondary to leptospirosis, in the absence of its common clinical features. Read More

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November 2018
2 Reads

Silver enhanced nano-gold dot blot immunoassay for leptospirosis.

J Microbiol Methods 2018 Nov 28;156:20-22. Epub 2018 Nov 28.

Medical Microbiology Laboratory, Department of Microbiology, Center for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India. Electronic address:

Leptospirosis is a widespread zoonotic disease and lacks in efficient diagnostic tools. In the present study, a nanogold based dot blot immunoassay was developed and evaluated for the detection of leptospirosis in human urine samples. This method was found to be rapid (<4 h) with higher sensitivity (>4. Read More

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November 2018

Diagnostic accuracy of rapid diagnostic tests for the early detection of leptospirosis.

J Infect Public Health 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. Electronic address:

Background: Leptospirosis is often misdiagnosed with several other tropical febrile illnesses in Malaysia due to similarities in clinical manifestations. Although treatment regimens could be started based on clinical judgments, early diagnosis has become paramount as a guide to chemotherapeutic interventions. Confirmed laboratory diagnosis through MAT or PCR is time consuming and usually available only in reference laboratories and not practical in healthcare settings. Read More

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November 2018

Molecular detection and clinical characteristics of Bartonella bacilliformis, Leptospira spp., and Rickettsia spp. in the Southeastern Peruvian Amazon basin.

BMC Infect Dis 2018 Dec 4;18(1):618. Epub 2018 Dec 4.

School of Medicine. Faculty of Health Sciences. Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Background: Acute febrile illness (AFI) represent a significant health challenge in the Peruvian Amazon basin population due to their diverse etiologies and the unavailability of specific on-site diagnostic methods, resulting in underreporting of cases. In Peru, one of the most endemic regions to dengue and leptospirosis is Madre de Dios, a region also endemic to emergent bacterial etiologic agents of AFI, such as bartonellosis and rickettsiosis, whose prevalence is usually underreported. We aimed to molecularly identify the presence of Leptospira spp. Read More

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December 2018
1 Read

Hepatic leptospiral infections in dogs without obvious renal involvement.

J Vet Intern Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

Background: Reports of chronic hepatitis in dogs caused by Leptospira spp. are confined to small case series. Fluorescence in situ hybridization (FISH) allows the identification of spirochetes in liver samples. Read More

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November 2018
3 Reads

A remotely sensed flooding indicator associated with cattle and buffalo leptospirosis cases in Thailand 2011-2013.

BMC Infect Dis 2018 Nov 29;18(1):602. Epub 2018 Nov 29.

Université Clermont Auvergne, Université de Lyon, INRA, VetAgro Sup, UMR EPIA, 63122, Saint Genès Champanelle, France.

Background: Leptospirosis is an important zoonotic disease worldwide, caused by spirochetes bacteria of the genus Leptospira. In Thailand, cattle and buffalo used in agriculture are in close contact with human beings. During flooding, bacteria can quickly spread throughout an environment, increasing the risk of leptospirosis infection. Read More

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November 2018
1 Read

Fatal Dengue, Chikungunya and Leptospirosis: The Importance of Assessing Co-infections in Febrile Patients in Tropical Areas.

Trop Med Infect Dis 2018 Nov 26;3(4). Epub 2018 Nov 26.

Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira 66003, Colombia.

The febrile patient from tropical areas, in which emerging arboviruses are endemic, represents a diagnostic challenge, and potential co-infections with other pathogens (i.e., bacteria or parasites) are usually overlooked. Read More

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November 2018
1 Read

Prevalence of dengue and leptospirosis co-infection in a tertiary care hospital in south India.

Iran J Microbiol 2018 Aug;10(4):227-232

Department of Microbiology, Government TD Medical College, Alappuzha, Kerala, India.

Background And Objectives: Dengue and Leptospirosis were often discussed separately with rash being more common in dengue and jaundice in leptospirosis. But with increasing reports of co-infection, the situation has become worse. The main objective of this study was to look for the presence of both Dengue and Leptospira IgM antibodies in serum samples of patients, presenting with acute febrile illness. Read More

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A Cross-Cutting Approach to Surveillance and Laboratory Capacity as a Platform to Improve Health Security in Uganda.

Health Secur 2018 ;16(S1):S76-S86

Kiersten Kugeler, PhD, MPH, is an Epidemiologist, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO.

Global health security depends on effective surveillance for infectious diseases. In Uganda, resources are inadequate to support collection and reporting of data necessary for an effective and responsive surveillance system. We used a cross-cutting approach to improve surveillance and laboratory capacity in Uganda by leveraging an existing pediatric inpatient malaria sentinel surveillance system to collect data on expanded causes of illness, facilitate development of real-time surveillance, and provide data on antimicrobial resistance. Read More

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January 2018
9 Reads

Diagnostic accuracy of leptospirosis whole-cell lateral flow assays: a systematic review and meta-analysis.

Clin Microbiol Infect 2018 Nov 22. Epub 2018 Nov 22.

Centre for International Health, University of Otago, Dunedin, New Zealand; Kilimanjaro Christian Medical Centre, Moshi, Tanzania; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America; Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America.

Background: Leptospirosis is under-diagnosed by clinicians in many high-incidence countries, as reference diagnostic tests are largely unavailable. Lateral flow assays (LFA) that use antigen derived from heat-treated whole cell Leptospira biflexa serovar Patoc have potential to improve leptospirosis diagnosis in resource-limited settings.

Objectives: We sought to summarize estimates of sensitivity and specificity of LFA by conducting a systematic review and meta-analysis of evaluations of the accuracy of LFA to diagnose human leptospirosis. Read More

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November 2018
2 Reads

Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean.

Acta Trop 2018 Nov 19;190:166-170. Epub 2018 Nov 19.

Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts, West Indies. Electronic address:

In this study, we investigated Leptospira infection and exposure in small Indian mongoose (Herpestes auropunctatus), an invasive animal species, in two different sites in the Caribbean island of Saint Kitts. Overall a low seroprevalence (12/148; 8.1%: 95%CI: 3. Read More

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November 2018
7 Reads

Compatibility between a rabies vaccine and a combined vaccine against canine distemper, adenovirosis, parvovirosis, parainfluenza virus and leptospirosis.

Vet Immunol Immunopathol 2018 Nov 2;205:93-96. Epub 2018 Nov 2.

Boehringer Ingelheim Animal Health, Centre de Recherche de Saint-Vulbas, Parc Industriel de la Plaine de l'Ain, 805 Allée des Cyprès, 01150, Saint-Vulbas, France.

In many cicumstances, veterinarians are requiring to be able to administer rabies vaccine in dogs at the same time as vaccinating against canine distemper, adenovirus, parvovirus, parainfluenza virus and leptospirosis. The aim of this study was to assess the compatibility between a multivalent vaccine and a rabies vaccine when injected at two separate sites. Lack of interference was assessed by comparing serological response to viral components during one year following primary vaccination with vaccines administered alone or concomitantly. Read More

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November 2018
1 Read

Complete genome sequence and in silico analysis of L. interrogans Canicola strain DU114: A virulent Brazilian isolate phylogenetically related to serovar Linhai.

Genomics 2018 Nov 17. Epub 2018 Nov 17.

Núcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico (CDTec), Universidade Federal Pelotas, Capão do Leão, Rio Grande do Sul, Brazil.

Canine leptospirosis is often caused by Leptospira interrogans serovar Canicola. Infected dogs may become asymptomatic carriers of the pathogen, which leads to many public health concerns. In this work, we present the complete genome sequencing and in silico analysis from a virulent Brazilian strain of L. Read More

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November 2018
3 Reads

Locally Acquired Leptospirosis in Expedition Racer, Manitoba, Canada.

Emerg Infect Dis 2018 Dec;24(12):2386-2388

Leptospirosis is found worldwide, except in northern regions. We report a case associated with a backcountry adventure race in Manitoba, Canada. Initially, nonspecific symptomatology and diagnostic pitfalls contributed to a delay in identification. Read More

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December 2018

Immuno-informatics based approaches to design a novel multi epitope-based vaccine for immune response reinforcement against Leptospirosis.

Mol Immunol 2018 Dec 15;104:128-138. Epub 2018 Nov 15.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Leptospirosis is known as a zoonotic disease of global importance originated from infection with the spirochete bacterium Leptospira. Although several leptospirosis vaccines have been tested, the vaccination is relatively unsuccessful in clinical application despite decades of research. Therefore, this study was conducted to construct a novel multi-epitope based vaccine against leptospirosis by using Hap1, LigA, LAg42, SphH and HSP58 antigens. Read More

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December 2018
3 Reads

Evaluation of an in-house LipL32 polymerase chain reaction for diagnosis of leptospirosis and its correlation with various serological diagnostic techniques.

Indian J Med Microbiol 2018 Jul-Sep;36(3):385-390

Department of Biotechnology, University of Mysore, Mysore, Karnataka, India.

Background: Leptospirosis is a zoonotic disease of ubiquitous distribution. During rainy seasons, in spring and summer and also during harvest times, the risk of leptospirosis increases as there are chances of frequent contact with infected rat population which is common in Karnataka as farming is a main source of income to the people here. There is a paucity of data regarding the prevalent serovars from Karnataka. Read More

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November 2018

Seroprevalence and distribution of leptospirosis serovars among wet market workers in northeastern, Malaysia: a cross sectional study.

BMC Infect Dis 2018 Nov 14;18(1):569. Epub 2018 Nov 14.

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.

Background: Leptospirosis is a zoonotic disease associated with occupations which exposed workers to environments contaminated with urine of infected animals. The objective of this study was to determine the seroprevalence of leptospirosis among wet market workers in Kelantan.

Methods: A cross sectional study was conducted in two main wet markets in Kelantan and 232 wet market workers were randomly selected. Read More

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November 2018
1 Read

Persistent Leptospiruria in Five Dogs Despite Antimicrobial Treatment (2000-2017).

J Am Anim Hosp Assoc 2018 Nov 14. Epub 2018 Nov 14.

From the Department of Small Animal Internal Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.

In dogs with leptospirosis, doxycycline therapy is recommended as the preferred therapy for its ability to eliminate the organism from all tissues, including the renal tubules. Elimination of organisms from the renal tubules terminates leptospiruria and prevents transmission of the organism. This report describes the discovery of persistent leptospiruria in the face of therapy with doxycycline in four dogs and enrofloxacin in one dog. Read More

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November 2018
4 Reads

MAT cross-reactions or vaccine cross-protection: retrospective study of 863 leptospirosis canine cases.

Heliyon 2018 Nov 2;4(11):e00869. Epub 2018 Nov 2.

Laboratoire de Bactériologie Médicale et Moléculaire des Leptospires, École Nationale Vétérinaire, ONIRIS, Route de Gachet, CS 40706, 44307 Nantes Cedex 03, France.

Dogs are naturally exposed to numerous pathogenic serogroups. Leptospirosis vaccines are claimed to afford a clinical protection restricted to the serogroups of which they are composed.

Objectives: Dogs exhibiting liver and kidney injury were suspected of having leptospirosis. Read More

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November 2018
8 Reads

Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis.

Front Cell Infect Microbiol 2018 30;8:384. Epub 2018 Oct 30.

Laboratory of Animal Viruses, Institute of Biotechnology and Molecular Biology, UNLP-CONICET, La Plata, Argentina.

Previous studies have suggested that macrophages may contribute to acute dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Gal-3) on the survival, clinical course, bacterial burden, interstitial nephritis, and chronic kidney fibrosis in serovar Copenhageni (LIC)-induced experimental murine leptospirosis. C57BL/6J mice depleted of macrophages by liposome-encapsulated clodronate treatment and infected with LIC presented a higher bacterial burden, had reduced subacute nephritis and enhanced chronic kidney fibrosis relative to untreated, infected mice. Read More

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October 2018
5 Reads

Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan.

Korean J Parasitol 2018 Oct 31;56(5):521-525. Epub 2018 Oct 31.

International Development Group, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Read More

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October 2018
4 Reads

Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design.

Biotechnol Bioeng 2018 Nov 12. Epub 2018 Nov 12.

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.

Recombinant antigens exhibit targeted protectiveproperties and offer important opportunities in the development of therapeutic technologies. Biophysical and structural methods have become important tools for the rational design and engineering of improved antigen-based vaccines. Vaccines containing Leptospira immunoglobulin-like (Lig) protein-derived antigens are currently the most promising candidates for protective immunity against the globally prevalent bacterial pathogen, Leptospira interrogans; however, vaccine trials using these domains have produced inconsistent results. Read More

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November 2018
3 Reads

Geographical and temporal distribution of the residual clusters of human leptospirosis in China, 2005-2016.

Sci Rep 2018 Nov 9;8(1):16650. Epub 2018 Nov 9.

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, QLD, 4343, Australia.

Human leptospirosis outbreaks still persistently occur in part of China, indicating that leptospirosis remains an important zoonotic disease in the country. Spatiotemporal pattern of the high-risk leptospirosis cluster and the key characteristics of high-risk areas for leptospirosis across the country are still poorly understood. Using spatial analytical approaches, we analyzed 8,158 human leptospirosis cases notified during 2005-2016 across China to explore the geographical distribution of leptospirosis hotspots and to characterize demographical, ecological and socioeconomic conditions of high-risk counties for leptospirosis in China. Read More

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November 2018
5 Reads
5.080 Impact Factor

Cardiac involvement in critically ill patients with leptospirosis: A prospective study using myocardial deformation imaging.

Eur Heart J Acute Cardiovasc Care 2018 Nov 8:2048872618809319. Epub 2018 Nov 8.

2 Division of Cardiology, University of Alberta, Canada.

Background:: Myocardial inflammation often complicates leptospirosis, a re-emerging global zoonosis. Leptospirosis associated myocardial dysfunction is equivocal and the pattern of cardiac involvement may not differ from that of sepsis associated myocarditis.

Methods:: We prospectively compared cardiac involvement in 113 intensive care unit patients with severe leptospirosis to 31 patients with sepsis syndrome using a comprehensive assessment comprising of clinical presentation, electrocardiography, two-dimensional echocardiography (with global longitudinal strain calculation), and cardiac biomarker evaluation. Read More

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November 2018
7 Reads

Spectrum of Diseases/conditions Exhibiting Hemostatic Abnormalities in Patients Admitted to a Medical Intensive Care Unit of a Tertiary Care Hospital.

Indian J Crit Care Med 2018 Oct;22(10):711-717

Department of Medicine, Topiwala National Medical College & B.Y.L. Nair Ch Hospital, Mumbai, Maharashtra, India.

Background And Aims: In a medical intensive care unit (MICU), many patients develop hemostatic abnormalities, ranging from abnormal clotting tests to frank bleeding. The aim of this study was to assess the etiology of diseases that present with bleeding, its common bleeding manifestations, incidence, MICU stay, mortality, and transfusion requirements in an Indian setup and also to assess if the Acute Physiology and Chronic Health Evaluation II (APACHE II) score can be used as a predictor for blood transfusion requirements.

Materials And Methods: Between July 2013 and August 2014, 200 patients with clinically significant bleeding admitted in the MICU were prospectively evaluated. Read More

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October 2018
6 Reads

Atypical virulence of Leptospira kirschneri serogroup Icterohaemorrhagiae isolated from capybaras (Hydrochoerus hydrochaeris) in hamster model.

Microb Pathog 2018 Oct 27;126:134-137. Epub 2018 Oct 27.

Laboratório de Bacteriologia Veterinária, Universidade Federal Fluminense, Niterói, RJ, Brazil. Electronic address:

Leptospirosis is an important zoonotic disease and, in urban areas, rodents are considered the main reservoir of Leptospira to human hosts. It has been described that capybaras, the world largest rodent, also harbor and shed leptospires by urine. Although not virulent to their hosts, strains of rodent origin are virulent for the hamster. Read More

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October 2018
3 Reads
2.000 Impact Factor

Leptospirosis in Poland in the years 2014-2017 – characteristics of infections and epidemiological surveillance data

Przegl Epidemiol 2018 ;72(3):303-312

National Institute of Public Health - National Institute of Hygiene, Department of Parasitology and Vector-borne Diseases

Objectives: The aim of the study was the analysis of current Leptospira spp. infections in Poland on the basis of blood serum samples tests results and clinical data collected from clinicians in the Laboratory NIPH-NIH.

Methods: Clinical materials from 48 patients with clinical symptoms suggesting Leptospira spp suspected of leptospirosis from the years 2014-2017 were included to the study. Read More

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January 2018
8 Reads

Knowledge, Attitudes, Practices and Health Beliefs toward Leptospirosis among Urban and Rural Communities in Northeastern Malaysia.

Int J Environ Res Public Health 2018 Nov 1;15(11). Epub 2018 Nov 1.

Health Department of Federal Territory Kuala Lumpur and Putrajaya, Jalan Cenderasari, Kuala Lumpur 50590, Malaysia.

Background: Leptospirosis is a zoonotic disease with a worldwide distribution, especially in developing countries such as Malaysia. This study was designed to explore the knowledge, attitudes, beliefs and practices (KABP) toward leptospirosis among the communities in northeastern Malaysia and to determine the sociodemographic factors associated with the KABP toward leptospirosis. A cross-sectional study using a stratified sampling method was conducted among 214 individuals in four locales in northeastern Malaysia. Read More

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November 2018
7 Reads
2.063 Impact Factor

Seroprevalence of Leptospira spp., Toxoplasma gondii, and Dirofilaria immitis in Free-Roaming Cats in Iowa.

Vector Borne Zoonotic Dis 2018 Nov 1. Epub 2018 Nov 1.

1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University , Ames, Iowa.

By the nature of their environment and behavior, free-roaming cats are at increased risk of exposure to a wide range of pathogens compared with client-owned cats. Consequently, free-roaming cats can act as a reservoir for possible zoonotic infections. In this study, 140 cats were prospectively recruited over a 12-month period from a free-roaming cat spay and neuter clinic and a local animal shelter in the state of Iowa. Read More

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November 2018
1 Read

Leptospira spp. in Rodents and Shrews from Afghanistan.

J Wildl Dis 2018 Oct 30. Epub 2018 Oct 30.

3 Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald-Insel Riems, Germany.

Leptospirosis is an occupational risk for military personnel and many cases have been reported worldwide. Rodents are the most important maintenance hosts for Leptospira spp. and may infect both animals and humans. Read More

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October 2018
1 Read

Seroprevalence, frequency of leptospiuria, and associated risk factors in horses in Kansas, Missouri, and Nebraska from 2016-2017.

PLoS One 2018 29;13(10):e0206639. Epub 2018 Oct 29.

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America.

Leptospirosis is a worldwide veterinary and public health concern, and well recognized infectious disease of horses. Seroprevalence rates vary with geography, but many studies have confirmed a high exposure rate. The correlation between seropositivity and shedding status has not been made in horses, however. Read More

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October 2018
1 Read

A 3-year retrospective analysis on the prevalence of antileptospiral antibodies among children in Chennai City, India.

J Med Microbiol 2018 Dec 29;67(12):1706-1710. Epub 2018 Oct 29.

1​Department of Experimental Medicine, The Tamil Nadu Dr M. G. R. Medical University, Guindy, Chennai - 600 032, India.

Purpose: Leptospirosis is a re-emerging infectious disease that has been reported from all over the world, including South India. Several studies have documented the prevalence of Leptospira in the general population. However, the data on leptospirosis in children were limited. Read More

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December 2018
4 Reads

Bilateral facial paralysis associated with leptospirosis.

Radiol Bras 2018 Sep-Oct;51(5):335

Universidade Federal do Espírito Santo (UFES), Vitória, ES, Brazil.

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October 2018

Economic benefit of leptospirosis prevention in Kelantan, Malaysia: Willingness-to-contribute approach.

Int J Health Plann Manage 2018 Oct 25. Epub 2018 Oct 25.

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Leptospirosis is an endemic disease in Malaysia. Despite the increasing incidence rate, knowledge on the economic assessment of preventing leptospirosis is still limited. This paper introduces the willingness-to-contribute (WTC) method for estimating the economic benefit of preventing leptospirosis. Read More

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October 2018
7 Reads

Leptospirosis following heavy rains in 2017 in Mumbai: Report of large-scale community chemoprophylaxis.

Natl Med J India 2018 Jan-Feb;31(1):19-21

Public Health Department, Municipal Corporation of Greater Mumbai, Mumbai, Maharashtra, India.

Background: Globally, cities get flooded due to heavy rains. As the incidence of leptospirosis increases after such flooding in Mumbai, community chemoprophylaxis to selected individuals was a consensus recommendation by experts.

Methods: We surveyed a total of 1 499 293 houses in severely affected areas of Mumbai (where there was waterlogging or high incidence of leptospirosis in the past) as well as in all slum areas. Read More

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October 2018
16 Reads

Falsely positive anti-glomerular basement membrane antibodies in a patient with hantavirus induced acute kidney injury - a case report.

BMC Nephrol 2018 Oct 22;19(1):286. Epub 2018 Oct 22.

Ziekenhuisgroep Twente, Department of Nephrology, Almelo, The Netherlands.

Background: Hantavirus infection is an uncommon cause of acute renal failure with massive proteinuria. Serology tests to support a presumptive diagnosis usually take a few days. During the initial work-up, autoimmune causes including anti-glomerular basement membrane (GBM) glomerulonephritis need to be excluded, because these require urgent therapy. Read More

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October 2018
7 Reads

vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation.

EBioMedicine 2018 Nov 15;37:428-441. Epub 2018 Oct 15.

Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, PR China; Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, PR China. Electronic address:

Backgroud: Leptospira interrogans is the major causative agent of leptospirosis, a worldwide zoonotic disease. Hemorrhage is a typical pathological feature of leptospirosis. Binding of von Willebrand factor (vWF) to platelet glycoprotein-Ibα (GPIbα) is a crucial step in initiation of platelet aggregation. Read More

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November 2018
6 Reads

Leptospirosis in Ukraine (Lviv Oblast): Clinical and Epidemiological Features.

Vector Borne Zoonotic Dis 2018 Oct 18. Epub 2018 Oct 18.

1 Department of Infectious Diseases, Danylo Halytsky Lviv National Medical University , Lviv, Ukraine .

The article describes the results of a retrospective analysis of medical records of 395 patients with a clinical diagnosis of leptospirosis treated at the Lviv Oblast Infectious Disease Clinical Hospital (Ukraine) between 2002 and 2016. The main risk factors for leptospirosis were contact with rodents or their excrements (26.84%) and bathing in ponds, small lakes, and reservoirs (10. Read More

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October 2018

Review of Diagnostic Procedures and Approaches to Infectious Causes of Reproductive Failures of Cattle in Australia and New Zealand.

Front Vet Sci 2018 2;5:222. Epub 2018 Oct 2.

Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, Hong Kong.

Infectious causes of reproductive failure in cattle are important in Australia and New Zealand, where strict biosecurity protocols are in place to prevent the introduction and spread of new diseases. ranks highly as an important cause of reproductive wastage along with fungal and bacterial infections. , a leading cause of abortion elsewhere in the world, is foreign, following successful programs to control and eradicate the disease. Read More

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October 2018

Characterization of patients transported with extracorporeal respiratory and/or cardiovascular support in the State of São Paulo, Brazil.

Rev Bras Ter Intensiva 2018 Jul-Sept;30(3):317-326

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brasil.

Objective: To characterize the transport of severely ill patients with extracorporeal respiratory or cardiovascular support.

Methods: A series of 18 patients in the state of São Paulo, Brazil is described. All patients were consecutively evaluated by a multidisciplinary team at the hospital of origin. Read More

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January 2018

Effects of natural infection by L. borgpetersenii serovar Hardjo type Hardjo-bovis and L. interrogans serovar Pomona, and leptospiral vaccination, on sheep growth.

Prev Vet Med 2018 Nov 17;159:196-202. Epub 2018 Sep 17.

School of Veterinary Science, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand. Electronic address:

In New Zealand, up to 97% of NZ sheep flocks are seropositive to Leptospira borgpetersenii serovar Hardjo and/or Leptospira interrogans Pomona, yet vaccination is rare. This study evaluated the impact of exposure to these serovars and of vaccination on sheep growth. One third of 2260 ewe lambs on eight farms were randomly selected and vaccinated with a primary and booster bivalent Hardjo and Pomona vaccine starting at one month of age on seven farms and at around five months of age on one farm. Read More

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November 2018

Importation of leptospirosis to New York from Israel by teen travellers.

J Travel Med 2018 Jan;25(1)

Department of Pediatrics, Hofstra Northwell School of Medicine, Hempstead, NY, USA.

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January 2018

Spatiotemporal dynamics and risk factors for human Leptospirosis in Brazil.

Sci Rep 2018 Oct 11;8(1):15170. Epub 2018 Oct 11.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Leptospirosis is an emerging neglected tropical disease with a worldwide significant global health burden. Between 2000 and 2016, there were 63,302 cases of human leptospirosis and 6,064 deaths reported in Brazil. We modeled the spatiotemporal risk dynamics of human leptospirosis morbidity and lethality, and attributed an easily interpretable risk-based priority index (PI) for all Brazilian federative units to suggest improvements to the national surveillance system. Read More

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October 2018
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Predictive risk mapping of an environmentally-driven infectious disease using spatial Bayesian networks: A case study of leptospirosis in Fiji.

PLoS Negl Trop Dis 2018 Oct 11;12(10):e0006857. Epub 2018 Oct 11.

Research School of Population Health, The Australian National University, Canberra, Australia.

Introduction: Leptospirosis is a zoonotic disease responsible for over 1 million severe cases and 60,000 deaths annually. The wide range of animal hosts and complex environmental drivers of transmission make targeted interventions challenging, particularly when restricted to regression-based analyses which have limited ability to deal with complexity. In Fiji, important environmental and socio-demographic factors include living in rural areas, poverty, and livestock exposure. Read More

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October 2018
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