6,305 results match your criteria Leptospirosis in Humans


Meta-analysis of risk factors for canine leptospirosis.

Prev Vet Med 2020 Jun 15;181:105037. Epub 2020 Jun 15.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Estación Experimental Agropecuaria Rafaela, Instituto Nacional de Tecnología Agropecuaria (INTA), Ruta 34 Km 227, Rafaela, Santa Fe, Argentina. Electronic address:

Leptospirosis is one of the most widespread zoonotic diseases, with more than one million human cases reported worldwide every year. Dogs could develop infections that range from asymptomatic to severe, and shed leptospires with their urine. Given their close contact with humans, dogs may act both as epidemiological links or as sentinels of pathogenic leptospires in the environment. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.105037DOI Listing

Infection in African Green Monkeys in an Endemic Area: An Opportunity for Comparative Studies in a Natural Environment.

Pathogens 2020 Jun 16;9(6). Epub 2020 Jun 16.

Behavioral Science Foundation, Basseterre KN 0101, Saint Kitts and Nevis.

This study was performed to investigate the potential asymptomatic reservoir status among African green monkeys (AGMs) in the Caribbean island of Saint Kitts, and whether there is any renal pathology associated with exposure. Forty-eight percent of AGMs tested were positive for antibodies by the microscopic agglutination test. DNA was detected in 4% of kidney samples tested using a 32 gene based PCR. Read More

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http://dx.doi.org/10.3390/pathogens9060474DOI Listing

Geoprocessing and spatial analysis for identifying leptospirosis risk areas: a systematic review.

Rev Inst Med Trop Sao Paulo 2020 5;62:e35. Epub 2020 Jun 5.

Universidade Federal Rural do Rio de Janeiro, Instituto de Medicina Veterinária, Departamento de Parasitologia Animal, Seropédica, Rio de Janeiro, Rio de Janeiro, Brazil.

Leptospirosis is a reemerging zoonosis caused by bacteria of the genus Leptospira sp. with global importance in the medical and veterinary fields, being responsible for about 59 thousand deaths each year in the world. The use of Geographic Information Systems (GIS) in the health sector is propitious and has been adopted by human and animal health professionals as an important tool in spatial analyses of health. Read More

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http://dx.doi.org/10.1590/S1678-9946202062035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274766PMC

Optimization of Culture Protocols to Isolate spp. from Environmental Water, Field Investigation, and Identification of Factors Associated with the Presence of spp. in the Environment.

Trop Med Infect Dis 2020 Jun 5;5(2). Epub 2020 Jun 5.

Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

The successful culture of spp. from the environment is challenging. Here, we optimized the isolation of spp. Read More

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http://dx.doi.org/10.3390/tropicalmed5020094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345561PMC

Leptospira interrogans in wild Boa constrictor snakes from Northeast Brazil peri‑urban rainforest fragments.

Acta Trop 2020 Jun 3;209:105572. Epub 2020 Jun 3.

Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil. Electronic address:

Leptospirosis, a disease that occurs worldwide, especially in tropical regions, is caused by bacteria of the genus Leptospira and affects mammals, amphibians, and reptiles. Boa constrictor snakes are commonly found in Atlantic rainforest fragments in peri‑urban areas, which indicates a greater possibility of the contact of these animals with humans residing there. Therefore, the aim of this work was to detect Leptospira spp infection through molecular assays in wild B. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105572DOI Listing

Complete Genome Sequence of Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka.

J Genomics 2020 22;8:49-52. Epub 2020 Apr 22.

Section of Infectious Disease, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.

Leptospirosis is an important cause of acute undifferentiated fever and complex multisystem febrile diseases in the tropics and subtropics. Understanding the evolution of especially as related to the clinical pathogenesis of leptospirosis is facilitated by systematic comparative genomic analysis of human-infecting isolates. Here, we announce the complete genome sequences of three strains that were isolated from blood of humans with undifferentiated fever in Sri Lanka. Read More

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http://dx.doi.org/10.7150/jgen.43953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256012PMC

Spatio-temporal analysis of leptospirosis in Eastern Amazon, State of Pará, Brazil.

Rev Bras Epidemiol 2020 1;23:e200041. Epub 2020 Jun 1.

Laboratory of Enviromental Microbiology, Universidade Federal do Pará, Belém, PA, Brazil.

Introduction: Brazil has registered more than 62,000 confirmed cases of leptospirosis between 2001 and 2017, with more than 2,000 cases confirmed in the State of Pará. Despite a large number of cases, no study has been conducted to trace the spatio-temporal profile of the disease.

Methodology: Confirmed cases of leptospirosis from 2001 to 2017 from the state of Pará were the basis for this space-time study. Read More

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http://dx.doi.org/10.1590/1980-549720200041DOI Listing

Prevalence of leptospirosis in vaccinated working dogs and humans with occupational risk

Biomedica 2020 05 1;40(Supl. 1):62-75. Epub 2020 May 1.

Grupo CIENVET, Departamento Salud Animal, Facultad de Ciencias Agropecuarias, Universidad de Caldas, Manizales, Colombia.

Introduction: Working dogs have been identified as a risk group for developing leptospirosis because they can be infected by Leptospira spp., which can be kept in the renal tubules and interstices for a long time, making them carriers and sources of infection for other hosts, including humans. Objective: To establish the prevalence of Leptospira spp. Read More

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http://dx.doi.org/10.7705/biomedica.5009DOI Listing

Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results.

BMC Infect Dis 2020 May 24;20(1):364. Epub 2020 May 24.

Hasan Sadikin Hospital - Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia.

Background: Reports of human rickettsial infection in Indonesia are limited. This study sought to characterize the epidemiology of human rickettsioses amongst patients hospitalized with fever at 8 tertiary hospitals in Indonesia.

Methods: Acute and convalescent blood from 975 hospitalized non-dengue patients was tested for Rickettsia IgM and IgG by ELISA. Read More

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http://dx.doi.org/10.1186/s12879-020-05057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245627PMC

[Epidemiological characteristics of leptospirosis in Sichuan province, 2004-2018].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 May;41(5):695-699

Department of Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To explore the epidemiological characteristics of leptospirosis in Sichuan province from 2004 to 2018, and provide evidence for the prevention and control of leptospirosis. The descriptive epidemiology analysis was conducted based on the epidemic data of leptospirosis collected from the national notifiable infectious disease reporting information system (NNIDRIS) and sentinel surveillance system in 11 areas in Sichuan from 2004 to 2018. The ArcGIS 10. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20190703-00491DOI Listing

Serological evidence of Leptospira sp. in humans from Fernando de Noronha Island, Brazil.

Comp Immunol Microbiol Infect Dis 2020 Apr 29;71:101486. Epub 2020 Apr 29.

Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil.

The prevalence of leptospirosis in humans is highly variable, being influenced by climatic factors, the presence of reservoirs, occupational exposure, recreational activity, and socioeconomic conditions. The objective of this study was to estimate the prevalence of Leptospira sp. and identify the predominant human serovars on the island of Fernando de Noronha, Brazil, based on a microscopic agglutination test. Read More

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http://dx.doi.org/10.1016/j.cimid.2020.101486DOI Listing

Novel genotypes of serogroup Sejroe isolated from human patients in Okinawa Prefecture, Japan.

J Med Microbiol 2020 Apr;69(4):587-590

Department of Bacteriology I, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of species. It is a public health issue in the tropics, including Okinawa, the southernmost prefecture of Japan. This study reports the first isolation of serogroup Sejroe from two human patients in Japan, and describes its molecular characterization using multilocus sequence typing (MLST) and multiple-locus variable-number tandem repeat analysis (MLVA). Read More

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http://dx.doi.org/10.1099/jmm.0.001169DOI Listing

High seroprevalence of anti- spp. antibodies in domestic and wild mammals from a mixed use rescue center in Ecuador: Lessons for "One Health" based conservation strategies.

One Health 2020 Dec 8;10:100140. Epub 2020 May 8.

One Health Research Group, Universidad de Las Américas, Quito, Ecuador.

Leptospirosis is a zoonotic disease of worldwide distribution that affects humans, domestic and wild animals. This study evaluates the frequency of anti- spp. antibodies in companion, livestock and wild mammals from a mixed use rescue center on Guayaquil, the main city of Ecuador. Read More

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http://dx.doi.org/10.1016/j.onehlt.2020.100140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226863PMC
December 2020

Frequency of Animal Leptospirosis in the Southern United States and the Implications for Human Health.

South Med J 2020 May;113(5):240-249

From the Gillings School of Global Public Health, University of North Carolina, Chapel Hill, and the Department of Marine, Earth, and Atmospheric Sciences, College of Sciences, North Carolina State University, Raleigh.

Leptospirosis is a zoonotic disease with symptoms in humans and animals, ranging from subclinical to serious and fatal. The disease occurs worldwide, but there is limited recognition of the public and animal health risks it poses in the southern United States. A systematic review of the frequency of animal leptospirosis in 17 states and jurisdictions covering the southern continental United States was performed to advance our understanding of the pathogen's distribution and identify transmission patterns that could be targeted for prevention efforts. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000001093DOI Listing

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina.

PLoS Negl Trop Dis 2020 04 24;14(4):e0008222. Epub 2020 Apr 24.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina.

Background: Leptospirosis is a zoonotic disease that can be transmitted by contact with the urine of infected mammals. Rodents play a mayor role in the transmission of leptospires to humans. The province of Santa Fe reports the greatest number of cases in Argentina. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182174PMC

Spatial distribution of leptospirosis incidence in the Upper Yangtze and Pearl River Basin, China: Tools to support intervention and elimination.

Sci Total Environ 2020 Jul 1;725:138251. Epub 2020 Apr 1.

School of Veterinary Science, The University of Queensland, Gatton, Queensland 4343, Australia; Children's Health and Environment Program, Child Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia. Electronic address:

Background: Since 2011 human leptospirosis incidence in China has remained steadily low with persistent pockets of notifications reported in communities within the Upper Yangtze River Basin (UYRB) and Pearl River Basin (PRB). To help guide health authorities within these residual areas to identify communities where interventions should be targeted, this study quantified the local effect of socioeconomic and environmental factors on the spatial distribution of leptospirosis incidence and developed predictive maps of leptospirosis incidence for UYRB and PRB.

Methods: Data on all human leptospirosis cases reported during 2005-2016 across the UYRB and PRB regions were geolocated at the county-level and included in the analysis. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138251DOI Listing
July 2020
4.099 Impact Factor

Incidence of human dog-mediated zoonoses and demographic characteristics/vaccination coverage of the domestic dog population in Algeria.

Rev Sci Tech 2019 12;38(3):809-821

Control of zoonotic diseases requires a One Health integrated action from both human and animal health sectors. The aims of the present study were to estimate the incidence of dog-mediated zoonoses in humans and to describe demographic characteristics and vaccination coverage of the domestic dog population in Algeria. The results show that rabies, leishmaniosis and echinococcosis are the major zoonoses in Algeria, with an average of 20. Read More

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http://dx.doi.org/10.20506/rst.38.3.3028DOI Listing
December 2019

A Validated Multiplex Real-Time PCR Assay for the Diagnosis of Infectious spp.: A Novel Assay for the Detection and Differentiation of Strains From Both Pathogenic Groups I and II.

Front Microbiol 2020 20;11:457. Epub 2020 Mar 20.

Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

Leptospirosis is recognized as the most globally widespread reemerging zoonosis and represents a serious threat for both human and animal health. Indeed, leptospirosis is linked to more than 60,000 human deaths per year and to incalculable economic burden as consequence of medical treatment costs and livestock loss. The increasing number of reports from species of pathogenic spp. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100377PMC

Cytokine response in human leptospirosis with different clinical outcomes: a systematic review.

BMC Infect Dis 2020 Apr 7;20(1):268. Epub 2020 Apr 7.

Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.

Background: Leptospirosis is a neglected zoonotic disease which is a major challenge for clinicians and public health professionals in tropical countries. The cytokine storm during the second (immune) phase is thought to be a major contributory factor for the leptospirosis disease severity. We aim to summarize evidence for cytokine response in leptospirosis at different clinical outcomes. Read More

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http://dx.doi.org/10.1186/s12879-020-04986-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137275PMC

The Leptospira interrogans LIC10774 is a multifunctional surface protein that binds calcium and interacts with host components.

Microbiol Res 2020 May 19;235:126470. Epub 2020 Mar 19.

Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, 05503-900, São Paulo, Brazil; Programa de Pós-Graduação Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900, São Paulo, Brazil. Electronic address:

Leptospirosis is a global re-emerging zoonosis, caused by pathogenic bacteria of the genus Leptospira. Humans are infected mainly through contact with contaminated water or soil. The understanding of the molecular mechanisms of leptospirosis through the characterization of unknown outer membrane proteins may contribute to the development of new treatments, diagnostic methods and vaccines. Read More

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http://dx.doi.org/10.1016/j.micres.2020.126470DOI Listing

Leptospira interrogans  and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia.

PLoS Negl Trop Dis 2020 03 23;14(3):e0008197. Epub 2020 Mar 23.

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Background: Leptospirosis, commonly known as rat-urine disease, is a global but endemic zoonotic disease in the tropics. Despite the historical report of leptospirosis in Malaysia, the information on human-infecting species is limited. Determining the circulating species is important to understand its epidemiology, thereby to strategize appropriate control measures through public health interventions, diagnostics, therapeutics and vaccine development. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117766PMC

spp. in Cats in Estonia: Seroprevalence and Risk Factors for Seropositivity.

Vector Borne Zoonotic Dis 2020 Jul 23;20(7):524-528. Epub 2020 Mar 23.

Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.

Leptospirosis is a zoonotic bacterial disease that affects humans and animals worldwide. Recently, more attention has been paid to spp. infections in domestic cats. Read More

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http://dx.doi.org/10.1089/vbz.2019.2555DOI Listing

Seroprevalence Among Ugandan Slaughter Cattle: Comparison of Sero-Status With Renal Infection.

Front Vet Sci 2020 28;7:106. Epub 2020 Feb 28.

Section of Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Despite evidence of both human and animal exposures in Uganda, the epidemiology of the disease is still not well-investigated. Contact with animals and their environments have been pointed out as potential source of infection with species in humans; and cattle may be an important reservoir in Uganda. In this cross-sectional study, we estimated the prevalence of anti- antibodies by the standard microscopic agglutination test (MAT); and associated risk factors among slaughtered cattle. Read More

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http://dx.doi.org/10.3389/fvets.2020.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058543PMC
February 2020

Leptospira infection and shedding in dogs in Thailand.

BMC Vet Res 2020 Mar 17;16(1):89. Epub 2020 Mar 17.

Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, LMU Munich, Veterinaerstrasse 13, 80539, Munich, Germany.

Background: Leptospirosis is a widespread zoonosis and has been recognized as a re-emerging infectious disease in humans and dogs, but prevalence of Leptospira shedding in dogs in Thailand is unknown. The aim of this study was to determine urinary shedding of Leptospira in dogs in Thailand, to evaluate antibody prevalence by microscopic agglutination test (MAT) and enzyme-linked immunosorbent assay (ELISA), and to assess risk factors for Leptospira infection. In Northern, Northeastern, and Central Thailand, 273 stray (n = 119) or client-owned (n = 154) dogs from rural (n = 139) or urban (n = 134) areas were randomly included. Read More

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http://dx.doi.org/10.1186/s12917-020-2230-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077098PMC
March 2020
1.777 Impact Factor

Zoonotic implications of camel diseases in Iran.

Vet Med Sci 2020 Mar 11. Epub 2020 Mar 11.

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran.

Approximately 60% of all human pathogens and 75% of emerging infectious diseases are zoonotic (of animal origin). Camel zoonotic diseases can be encountered in all camel-rearing countries. In this article, all studies carried out on camel zoonotic diseases in Iran are reviewed to show the importance of camels for public health in this country. Read More

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http://dx.doi.org/10.1002/vms3.239DOI Listing

Doxycycline for Prevention of Spirochetal Infections-Status Report.

Authors:
Gary P Wormser

Clin Infect Dis 2020 Mar 11. Epub 2020 Mar 11.

Division of Infectious Diseases, New York Medical College, Valhalla, NY.

Important human infections caused by spirochetal microorganisms include Lyme disease, syphilis, leptospirosis, and tick-borne relapsing fever. Doxycycline prophylactic regimens have been shown to significantly reduce the risk for developing all of these infections in potentially exposed individuals, which is highly clinically relevant since no vaccines to prevent these infections in humans are currently available. Additional data, however, are needed to define more precisely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and syphilis, infections that can be potentially prevented by a single 200 mg dose of doxycycline given within 72 hours post-exposure. Read More

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http://dx.doi.org/10.1093/cid/ciaa240DOI Listing

First report of pathogenic Leptospira spp. isolated from urine and kidneys of naturally infected cats.

PLoS One 2020 10;15(3):e0230048. Epub 2020 Mar 10.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Leptospirosis is one of the most widespread zoonotic diseases and can infect both humans and animals worldwide. Healthy cat, as a potential source of exposure to humans, are likely underestimated owing to the lack of overt clinical signs associated with Leptospira spp. infection in this species. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230048PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064249PMC
June 2020
3.234 Impact Factor

Strategies used by Leptospira spirochetes to evade the host complement system.

FEBS Lett 2020 Mar 9. Epub 2020 Mar 9.

Laboratory of Complement, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Brazil.

Leptospires are highly invasive spirochetes equipped with efficient strategies for dissemination in the host. The Leptospira genus currently comprises 64 species divided into two major clades: the saprophytes composed of nonpathogenic, free-living organisms, and the pathogens encompassing all the species that cause mild or severe infections in humans and animals. While saprophytes are highly susceptible to the lytic action of the complement system, pathogenic (virulent) strains have evolved virulence strategies that allow efficient colonization of a variety of hosts and target organs, including mechanisms to circumvent hosts' innate and acquired immune responses. Read More

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http://dx.doi.org/10.1002/1873-3468.13768DOI Listing

Cultural, histochemical, and immunohistochemical detection of pathogenic species in the kidneys of cattle slaughtered in two abattoirs in Southwest Nigeria.

J Immunoassay Immunochem 2020 May 6;41(3):337-353. Epub 2020 Mar 6.

Department of Veterinary Public Health and Reproduction, Federal University of Agriculture, Abeokuta, Nigeria.

The impact of leptospirosis on food animals and humans has not been fully elucidated. This study was designed to determine the prevalence of pathogenic organism in renal tissues of slaughtered cattle from two major abattoirs in southwestern Nigeria. One hundred and seventy (170) kidney samples of different breeds, ages, and sexes were collected and examined using cultural isolation, microscopic agglutination test (MAT), Warthin silver (WSs) impregnation and immunohistochemistry (IH). Read More

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http://dx.doi.org/10.1080/15321819.2020.1736096DOI Listing

Wild rodents and insectivores as carriers of pathogenic Leptospira and Toxoplasma gondii in The Netherlands.

Vet Med Sci 2020 Mar 5. Epub 2020 Mar 5.

Wageningen University & Research , Livestock Research, Wageningen, The Netherlands.

Small mammals such as rodents can to carry zoonotic pathogens. Currently, there is impaired knowledge on zoonotic pathogens in rodents and insectivores in the Netherlands. This limits opportunities for preventive measures and complicates risk-assessments for zoonotic transmission to humans. Read More

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http://dx.doi.org/10.1002/vms3.255DOI Listing

Leptospirosis in an asplenic patient -case report.

BMC Infect Dis 2020 Feb 28;20(1):186. Epub 2020 Feb 28.

Departamento de Biología Molecular e Histocompatibilidad, Dirección de investigación, Hospital General "Dr. Manuel Gea González", Mexico City, Mexico.

Background: The presentation of clinical leptospirosis has been historically associated with animal workers, slaughterhouse workers and medical veterinarians. This association has shifted to be related to flooding events and outdoor activities; few cases are related to high-risk factors found in immunosuppressed patients. Scarcely a handful of cases have serological evidence of immune response against Leptospira serovar Bratislava representing serogroup Australis, a serovar associated with poor reproductive performance in swine and horses, and recently with cats. Read More

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http://dx.doi.org/10.1186/s12879-020-4869-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048021PMC
February 2020

A first insight into the genomic diversity of Leptospira strains isolated from patients in Cuba.

PLoS One 2020 27;15(2):e0229673. Epub 2020 Feb 27.

Biology of Spirochetes Unit, Institut Pasteur, Paris, France.

Leptospirosis is a neglected disease causing severe infections in humans and animals. Due in part to misdiagnosis, this infectious disease results in nearly 60,000 deaths per year around the globe. This study represents the first effort to describe the diversity of pathogenic Leptospira in Cuba based on whole-genome sequencing. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229673PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046204PMC

Leptospirosis in Indonesia: diagnostic challenges associated with atypical clinical manifestations and limited laboratory capacity.

BMC Infect Dis 2020 Feb 27;20(1):179. Epub 2020 Feb 27.

National Institute of Health Research and Development (NIHRD), Ministry of Health Republic of Indonesia, Jakarta, Indonesia.

Background: The burden of leptospirosis in Indonesia is poorly understood. Data from an observational study conducted from 2013 to 2016 in seven cities across Indonesia was used to estimate the incidence of leptospirosis and document its clinical manifestations in patients requiring hospitalization.

Methods: Specimens from patients hospitalized with acute fever were collected at enrollment, 14-28 days, and 3 months. Read More

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http://dx.doi.org/10.1186/s12879-020-4903-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045408PMC
February 2020

Leptospira interrogans infection of southern tamanduas (Tamandua tetradactyla, Linnaeus, 1758) in Brazil.

Transbound Emerg Dis 2020 Feb 20. Epub 2020 Feb 20.

Universidade Federal da Paraíba, Areia, Paraíba, Brazil.

Leptospirosis is a zoonotic disease of global importance caused by an obligate aerobic spirochaete that infects a wide variety of domestic and wild animals. Natural hosts are asymptomatic or show moderate signs of the disease. Accidental hosts develop a severe, often lethal, form of the disease. Read More

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http://dx.doi.org/10.1111/tbed.13523DOI Listing
February 2020

Novel kidney injury biomarkers in tropical infections: a review of the literature.

Rev Inst Med Trop Sao Paulo 2020 14;62:e14. Epub 2020 Feb 14.

Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Medicina Clínica, Programa de Pós-Graduação em Ciências Médicas, Fortaleza, Ceará, Brazil.

Tropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associated with increased patients' morbidity and mortality. In most countries, kidney disease associated to tropical diseases is attended at health services with poor infrastructure and inadequate preventive measures. Read More

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http://dx.doi.org/10.1590/S1678-9946202062014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032010PMC

Muskrats are greater carriers of pathogenic Leptospira than coypus in ecosystems with temperate climates.

PLoS One 2020 19;15(2):e0228577. Epub 2020 Feb 19.

Nancy Laboratory for Rabies and Wildlife, ANSES, Malzéville, France.

Knowledge on the possible sources of human leptospirosis, other than rats, is currently lacking. To assess the distribution pattern of exposure and infection by Leptospira serogroups in the two main semi-aquatic rodents of Western France, coypus (Myocastor coypus) and muskrats (Ondatra zibethicus), results of micro-agglutination testing and renal tissue PCR were used. In coypus, the apparent prevalence was 11% (n = 524, CI95% = [9% - 14%]), seroprevalence was 42% (n = 590, CI95% = [38% - 46%]), and the predominant serogroup was Australis (84%). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228577PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029846PMC

[Dramatic achievements in infectious disease prevention and treatment in China during the past 70 years].

Authors:
W Z Yang

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Dec;40(12):1493-1498

Chinese Center for Disease Control and Prevention, Beijing 102206, China.

At the beginning of the founding of People's Republic of China, infectious diseases, such as smallpox, plague, cholera, dysentery, typhoid, measles, diphtheria, pertussis, meningitis, mumps, schistosomiasis, Kala Azar, hemorrhagic fever, leptospirosis, encephalitis B, typhus, malaria, Kala Azar, leprosy, scarlet fever and pinkeye, remained as epidemic in the country and endangered people's health. During the past 70 years, the Chinese government spent huge efforts in infectious disease prevention and treatment by promulgating and implementing series of relative policies, laws and strategies, and also encouraged all Chinese people to participate in. The achievements of these efforts in controlling infectious disease epidemic were extremely successful. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.12.001DOI Listing
December 2019

Leptospira spp., a genus in the stage of diversity and genomic data expansion.

Authors:
K Caimi P Ruybal

Infect Genet Evol 2020 Jul 13;81:104241. Epub 2020 Feb 13.

Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), Facultad de Medicina, Paraguay 2155 Piso: 12, CABA 1121, Argentina.

Leptospirosis is a widespread global zoonotic bacterial disease with a noteworthy human-animal-ecosystem interface. The disease presents different clinical manifestations and a high mortality and morbidity rates in humans and animals throughout the world. Characterization and correct classification of Leptospira isolates is essential for a better understanding the epidemiological properties of the disease. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104241DOI Listing

Diagnostic accuracy of genetic markers and nucleic acid techniques for the detection of Leptospira in clinical samples: A meta-analysis.

PLoS Negl Trop Dis 2020 02 12;14(2):e0008074. Epub 2020 Feb 12.

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.

Background: Leptospirosis is often difficult to diagnose because of its nonspecific symptoms. The drawbacks of direct isolation and serological tests have led to the increased development of nucleic acid-based assays, which are more rapid and accurate. A meta-analysis was performed to evaluate the diagnostic accuracy of genetic markers for the detection of Leptospira in clinical samples. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041858PMC
February 2020

Comparative genomic analysis of Chinese human leptospirosis vaccine strain and circulating isolate.

Hum Vaccin Immunother 2020 Jun 11;16(6):1345-1353. Epub 2020 Feb 11.

Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University , Nanchang, People's Republic of China.

Leptospira Interrogans: serogroup Canicola is one of the most important pathogens causing leptospirosis and is used as a vaccine strain of the current Chinese human leptospirosis accine. To characterize leptospiral pathogens, serogroup Canicola vaccine strain 611 and circulating isolate LJ178 from different hosts at different periods were sequenced using a combined strategy of Illumina X10 and PacBio technologies, and a comprehensive comparative analysis with other published strains was conducted in this study. High levels of genomic similarities were observed between vaccine strain 611 and circulating isolate LJ178; both had two circular chromosomes and two circular extrachromosomal replicons. Read More

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http://dx.doi.org/10.1080/21645515.2020.1720439DOI Listing

Leptospirosis presented with erythema nodosum on four limbs: an unusual presenting.

Oxf Med Case Reports 2020 Jan 31;2020(1):omz130. Epub 2020 Jan 31.

Medical Student, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Leptospirosis is a common disease between humans and animals characterized by a wide range of clinical manifestations. Erythema nodosum (EN) is a common clinical form of panniculitis or subcutaneous adipose inflammation caused by hypersensitivity responses to antigens, but the presence of EN in a subject with leptospirosis is a very rare case presentation. We will present a 42-year-old man with a headache, myalgia, nausea and rigid tender on the shin and both forearms, which was a typical form of EN lesions. Read More

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http://dx.doi.org/10.1093/omcr/omz130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996038PMC
January 2020

Raccoons () and Striped Skunks () as Potential Reservoirs of spp. in California.

Vector Borne Zoonotic Dis 2020 Jun 4;20(6):418-426. Epub 2020 Feb 4.

Department of Veterinary Medicine and Epidemiology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Leptospirosis is a globally important, fatal disease of humans, and over 160 species of animals are associated with more than 250 bacterial serovars in 64 species, but its ecology varies regionally and has changed over time with expansion of human development on previously agricultural and wild land. Sporadic human cases and clusters of canine leptospirosis, primarily attributable to serogroup Pomona, have been detected in northern California. Small mesocarnivores such as raccoons and skunks frequent peridomestic space across much of the western United States and could serve as reservoirs for human and canine leptospirosis. Read More

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http://dx.doi.org/10.1089/vbz.2019.2528DOI Listing

Leptospiral shedding and seropositivity in shelter dogs in the Cumberland Gap Region of Southeastern Appalachia.

PLoS One 2020 30;15(1):e0228038. Epub 2020 Jan 30.

College of Veterinary Medicine, Lincoln Memorial University, Harrogate, TN, United States of America.

Background: Leptospirosis, caused by pathogenic Leptospira spp., is a zoonotic infection that affects humans, dogs and many other mammalian species. Virtually any mammalian species can act as asymptomatic reservoir, characterized by chronic renal carriage and shedding of a host-adapted leptospiral serovar. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992200PMC

A systematic review of Leptospira in water and soil environments.

PLoS One 2020 27;15(1):e0227055. Epub 2020 Jan 27.

Leptospirosis Research and Expertise Unit, Institut Pasteur in New Caledonia, Institut Pasteur International Network, Noumea, New Caledonia.

Background: Leptospirosis, caused by pathogenic Leptospira, is a zoonosis of global distribution. This infectious disease is mainly transmitted by indirect exposure to urine of asymptomatic animals via the environment. As human cases generally occur after heavy rain, an emerging hypothesis suggests that rainfall re-suspend leptospires together with soil particles. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227055PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984726PMC
April 2020
3.234 Impact Factor

[Leptospirosis revealed by acute pancreatitis].

Pan Afr Med J 2019 11;34:83. Epub 2019 Oct 11.

Service de Réanimation, CHU Mohamed VI, Faculté de Médecine et de Pharmacie d'Oujda, Université Mohammed 1, Oujda, Maroc.

Leptospirosis is an ubiquitous anthropozoonosis particularly frequent in the tropical climate zone. It is caused by gram negative, strictly aerobic bacteria belonging to the order Spirochaetales and to the family Leptospira whose transmission usually occurs through contact with water sources contaminated with animal urine (carriers). Acute pancreatitis is a rare complication of leptospirosis; it is associated with high mortality rates. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.83.15680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945671PMC
January 2020

A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction.

J Immunol Res 2019 16;2019:7515346. Epub 2019 Dec 16.

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, China.

Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. Read More

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http://dx.doi.org/10.1155/2019/7515346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942865PMC

Development and Validation of a simple score for diagnosis of Leptospirosis at outpatient departments.

PLoS Negl Trop Dis 2020 01 9;14(1):e0007977. Epub 2020 Jan 9.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: Leptospirosis is an important zoonotic disease within the tropics. Diagnosing leptospirosis is a clinical obstacle, as clinical presentations are similar to other tropical infectious diseases. Available serological tests are often insensitive and not cost-effective. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975559PMC
January 2020

When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use.

PLoS One 2020 8;15(1):e0227409. Epub 2020 Jan 8.

School of Public Health, Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.

Background: Febrile illness caused by viral and bacterial diseases (e.g., dengue and leptospirosis) often have similar symptoms and are difficult to differentiate without diagnostic tests. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948826PMC

Investigation of Infection in Stray Animals in Songkhla, Thailand: Leptospirosis Risk Reduction in Human.

Vector Borne Zoonotic Dis 2020 Jun 6;20(6):432-435. Epub 2020 Jan 6.

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Leptospirosis is a zoonosis of public health concern in Thailand. Human leptospirosis presents severe illness and can be fatal due to pulmonary hemorrhage, kidney failure, or cardiac impairment. Infected animals show no clinical signs and play an important role in the infection of humans and other hosts. Read More

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http://dx.doi.org/10.1089/vbz.2019.2549DOI Listing

Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review.

Eur J Clin Microbiol Infect Dis 2020 May 2;39(5):835-846. Epub 2020 Jan 2.

Laboratory Division, ICMR-National Institute of Epidemiology, R-127, 2nd Main Road, TNHB, Ayapakkam, Chennai, Tamil Nadu, 600 077, India.

Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected, reemerging disease of global public health importance with respect to morbidity and mortality both in humans and animals. Due to negligence, rapid, unplanned urbanization, and poor sanitation, leptospirosis emerges as a leading cause of acute febrile illness in many of the developing countries. Read More

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http://dx.doi.org/10.1007/s10096-019-03797-4DOI Listing