5,992 results match your criteria Leptospirosis in Humans


Sanitation workers from Portugal: Is there evidence of Leptospira spp?

J Infect Public Health 2019 Feb 15. Epub 2019 Feb 15.

Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Portugal; Global Health and Tropical Medicine (GHTM), UNL, Portugal.

Leptospires are spirochetes of Leptospira genus. Infection in humans occurs by penetration into the mucous membranes, or into the skin (small wounds or abrasions). Humans are infected when they contact with urine of rodents, the main reservoirs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193007
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http://dx.doi.org/10.1016/j.jiph.2019.02.001DOI Listing
February 2019
1 Read

Identification of a novel protein in the genome sequences of Leptospira interrogans with the ability to interact with host's components.

J Microbiol Immunol Infect 2019 Jan 22. Epub 2019 Jan 22.

Laboratorio Especial de Desenvolvimento de Vacinas-Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, Sao Paulo, SP, Brazil. Electronic address:

Background: Leptospirosis is an infectious disease that affects humans and animals worldwide. The etiological agents of this disease are the pathogenic species of the genus Leptospira. The mechanisms involved in the leptospiral pathogenesis are not full understood. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.012DOI Listing
January 2019
1 Read

Pathogenic Leptospira species are widely disseminated among small mammals in Atlantic Forest biome.

Transbound Emerg Dis 2019 Jan 31. Epub 2019 Jan 31.

Universidade Federal Fluminense, Laboratório de Bacteriologia Veterinária, Instituto Biomédico, Niterói, Rio de Janeiro, Brazil.

Leptospirosis is a common worldwide bacterial zoonosis and has been studied in One Health approaches. Small mammals are described as the most important maintenance reservoirs of several pathogens in nature, including leptospires. The aim of this study was to identify infection by leptospires among small mammals on the Atlantic forest biome and evaluate their potential as carriers of these spirochetes. Read More

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http://dx.doi.org/10.1111/tbed.13135DOI Listing
January 2019

Leptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay.

Transbound Emerg Dis 2019 Jan 26. Epub 2019 Jan 26.

Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Montevideo, Uruguay.

Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identification of the agent. Here, we report one confirmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5. Read More

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http://dx.doi.org/10.1111/tbed.13133DOI Listing
January 2019
5 Reads

Junctional Rhythm: A Rare Sign in Leptospirosis.

Indian J Crit Care Med 2018 Dec;22(12):889-891

Department of Radiation Oncology, RIMS, Ranchi, Jharkhand, India.

Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311981PMC
December 2018
2 Reads

Despite high-risk exposures, no evidence of zoonotic transmission during a canine outbreak of leptospirosis.

Zoonoses Public Health 2019 Mar 7;66(2):223-231. Epub 2019 Jan 7.

Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.

Leptospirosis is a bacterial zoonosis that affects many mammals, including humans and dogs; dogs can transmit the bacteria to humans, but the frequency of transmission and highest risk exposures are poorly understood. During 2016-2017, the Maricopa County Department of Public Health, Arizona Department of Health Services and Centers for Disease Control and Prevention investigated the zoonotic potential of a canine leptospirosis outbreak in the Phoenix metro area. We identified symptomatic persons exposed to canine leptospirosis cases by conducting active and passive surveillance. Read More

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http://doi.wiley.com/10.1111/zph.12557
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http://dx.doi.org/10.1111/zph.12557DOI Listing
March 2019
18 Reads

Comparison of Mycobacterium ulcerans (Buruli ulcer) and Leptospira sp. (Leptospirosis) dynamics in urban and rural settings.

PLoS Negl Trop Dis 2019 01 7;13(1):e0007074. Epub 2019 Jan 7.

Equipe EA 3593, Ecosystèmes amazoniens et pathologie tropicale, Université de la Guyane, Cayenne, Guyane française.

Background: Zoonotic pathogens respond to changes in host range and/or pathogen, vector and host ecology. Environmental changes (biodiversity, habitat changes, variability in climate), even at a local level, lead to variability in environmental pathogen dynamics and can facilitate their transmission from natural reservoirs to new susceptible hosts. Whilst the environmental dynamics of aquatic bacteria are directly linked to seasonal changes of their habitat they also rely on the ecological processes underpining their transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336349PMC
January 2019
2 Reads

Human Mozdok leptospirosis first diagnosed by serum agglutinin-absorption tests in the Slovak Republic.

Epidemiol Mikrobiol Imunol 2018 ;67(3):114-120

Introduction: The serovar Mozdok related leptospirosis in humans were not yet feasibly diagnosed using merely the standard micro-agglutination test (MAT) what was perhaps due to the impossibility to distinguish them from illnesses that are caused by Leptospira strains belonging to other serovars of the serogroup Pomona. On the contrary, leptospires of the Mozdok serovar were cultured from rodents and domestic animals world-wide including Central Europe where only Leptospira strains of the serovars Pomona and Mozdok are known to be present till now.

Study Objective: The aim of the study was to discover if leptospires of Mozdok serovar may cause human leptospirosis that remained hidden till now among infections diagnosed merely by MAT as Pomona illnesses. Read More

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January 2018
1 Read

Leptospira infection and shedding in cats in Thailand.

Transbound Emerg Dis 2018 Dec 23. Epub 2018 Dec 23.

Clinic of Small Animal Internal Medicine, Centre of Clinical Veterinary Medicine LMU Munich, Munich, Germany.

In Thailand, leptospirosis is considered an emerging disease in humans and animals. Many species can shed pathogenic Leptospira, including domestic cats (felis catus), which might be able to pose a risk to humans. There are no studies on Leptospira infections in cats in Thailand, but in other countries, it was demonstrated that cats can shed pathogenic Leptospira with high prevalences. Read More

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http://doi.wiley.com/10.1111/tbed.13110
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http://dx.doi.org/10.1111/tbed.13110DOI Listing
December 2018
7 Reads

Development of real-time loop-mediated isothermal amplification (RealAmp) method for sensitive and rapid detection of pathogenic and nonpathogenic Leptospira.

Lett Appl Microbiol 2019 Feb;68(2):196-203

Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Leptospirosis is a zoonotic disease that is spread through water contaminated with the spirochete Leptospira. In our study, RealAmp (real-time loop-mediated isothermal amplification) was developed to distinguish between pathogenic and nonpathogenic Leptospira spp. Melt curve analysis of RealAmp showed two distinct melt curves for pathogenic and nonpathogenic Leptospira spp with a Tm value of 90 ± 2 and 88 ± 2°C. Read More

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http://doi.wiley.com/10.1111/lam.13108
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http://dx.doi.org/10.1111/lam.13108DOI Listing
February 2019
1 Read

Leptospirosis complicated with Guillain Barre syndrome, papillitis and thrombotic thrombocytopenic Purpura; a case report.

BMC Infect Dis 2018 Dec 22;18(1):691. Epub 2018 Dec 22.

National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Background: Leptospirosis is a zoonosis commonly prevalent in tropical countries. Clinical course of leptospirosis varies from mild to severe disease. Here we present a case of leptospirosis complicated with Guillain-Barre Syndrome (GBS), papillitis, and Thrombotic Thrombocytopenic Purpura(TTP). Read More

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http://dx.doi.org/10.1186/s12879-018-3616-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303948PMC
December 2018
2 Reads

Leptospirosis.

Workplace Health Saf 2018 Dec 21:2165079918818582. Epub 2018 Dec 21.

1 University of Alabama at Birmingham.

Leptospirosis is a leading zoonotic disease for morbidity and mortality in humans globally. Occupational health nurses should teach workers and the public about leptospirosis and the importance of disrupting the infection source through rodent control, animal vaccination, and flood prevention. Read More

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http://dx.doi.org/10.1177/2165079918818582DOI Listing
December 2018

Molecular detection and clinical characteristics of Bartonella bacilliformis, Leptospira spp., and Rickettsia spp. in the Southeastern Peruvian Amazon basin.

BMC Infect Dis 2018 Dec 4;18(1):618. Epub 2018 Dec 4.

School of Medicine. Faculty of Health Sciences. Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Background: Acute febrile illness (AFI) represent a significant health challenge in the Peruvian Amazon basin population due to their diverse etiologies and the unavailability of specific on-site diagnostic methods, resulting in underreporting of cases. In Peru, one of the most endemic regions to dengue and leptospirosis is Madre de Dios, a region also endemic to emergent bacterial etiologic agents of AFI, such as bartonellosis and rickettsiosis, whose prevalence is usually underreported. We aimed to molecularly identify the presence of Leptospira spp. Read More

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http://dx.doi.org/10.1186/s12879-018-3541-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280516PMC
December 2018
2 Reads

A remotely sensed flooding indicator associated with cattle and buffalo leptospirosis cases in Thailand 2011-2013.

BMC Infect Dis 2018 Nov 29;18(1):602. Epub 2018 Nov 29.

Université Clermont Auvergne, Université de Lyon, INRA, VetAgro Sup, UMR EPIA, 63122, Saint Genès Champanelle, France.

Background: Leptospirosis is an important zoonotic disease worldwide, caused by spirochetes bacteria of the genus Leptospira. In Thailand, cattle and buffalo used in agriculture are in close contact with human beings. During flooding, bacteria can quickly spread throughout an environment, increasing the risk of leptospirosis infection. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3537-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267035PMC
November 2018
1 Read

Seroprevalence and distribution of leptospirosis serovars among wet market workers in northeastern, Malaysia: a cross sectional study.

BMC Infect Dis 2018 Nov 14;18(1):569. Epub 2018 Nov 14.

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.

Background: Leptospirosis is a zoonotic disease associated with occupations which exposed workers to environments contaminated with urine of infected animals. The objective of this study was to determine the seroprevalence of leptospirosis among wet market workers in Kelantan.

Methods: A cross sectional study was conducted in two main wet markets in Kelantan and 232 wet market workers were randomly selected. Read More

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http://dx.doi.org/10.1186/s12879-018-3470-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236877PMC
November 2018
1 Read

Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan.

Korean J Parasitol 2018 Oct 31;56(5):521-525. Epub 2018 Oct 31.

International Development Group, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.5.521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243181PMC
October 2018
14 Reads

Leptospira spp. in Rodents and Shrews from Afghanistan.

J Wildl Dis 2018 Oct 30. Epub 2018 Oct 30.

3 Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald-Insel Riems, Germany.

Leptospirosis is an occupational risk for military personnel and many cases have been reported worldwide. Rodents are the most important maintenance hosts for Leptospira spp. and may infect both animals and humans. Read More

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http://dx.doi.org/10.7589/2018-05-122DOI Listing
October 2018
1 Read

A 3-year retrospective analysis on the prevalence of antileptospiral antibodies among children in Chennai City, India.

J Med Microbiol 2018 Dec 29;67(12):1706-1710. Epub 2018 Oct 29.

1​Department of Experimental Medicine, The Tamil Nadu Dr M. G. R. Medical University, Guindy, Chennai - 600 032, India.

Purpose: Leptospirosis is a re-emerging infectious disease that has been reported from all over the world, including South India. Several studies have documented the prevalence of Leptospira in the general population. However, the data on leptospirosis in children were limited. Read More

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http://www.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.000825DOI Listing
December 2018
6 Reads

Characterization of patients transported with extracorporeal respiratory and/or cardiovascular support in the State of São Paulo, Brazil.

Rev Bras Ter Intensiva 2018 Jul-Sept;30(3):317-326

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brasil.

Objective: To characterize the transport of severely ill patients with extracorporeal respiratory or cardiovascular support.

Methods: A series of 18 patients in the state of São Paulo, Brazil is described. All patients were consecutively evaluated by a multidisciplinary team at the hospital of origin. Read More

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http://dx.doi.org/10.5935/0103-507X.20180052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180471PMC
December 2018
1 Read

Predictive risk mapping of an environmentally-driven infectious disease using spatial Bayesian networks: A case study of leptospirosis in Fiji.

PLoS Negl Trop Dis 2018 10 11;12(10):e0006857. Epub 2018 Oct 11.

Research School of Population Health, The Australian National University, Canberra, Australia.

Introduction: Leptospirosis is a zoonotic disease responsible for over 1 million severe cases and 60,000 deaths annually. The wide range of animal hosts and complex environmental drivers of transmission make targeted interventions challenging, particularly when restricted to regression-based analyses which have limited ability to deal with complexity. In Fiji, important environmental and socio-demographic factors include living in rural areas, poverty, and livestock exposure. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006857
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http://dx.doi.org/10.1371/journal.pntd.0006857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198991PMC
October 2018
3 Reads

Uncommon manifestation of leptospirosis: a diagnostic challenge.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Leptospirosis is a zoonotic disease commonly affecting the tropical countries. It may have protean clinical manifestations including hepatorenal dysfunction, myocarditis, pulmonary haemorrhage, meningitis, optic neuritis and rhabdomyolysis. Neurological manifestation of leptospirosis without the classical hepatorenal dysfunction is a rare entity. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22528
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http://dx.doi.org/10.1136/bcr-2018-225281DOI Listing
October 2018
2 Reads

Coinfections as an aetiology of acute undifferentiated febrile illness among adult patients in the sub-Himalayan region of north India.

J Vector Borne Dis 2018 Apr-Jun;55(2):130-136

Department of Medicine, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.

Background & Objectives: In India, certain geographic regions witness simultaneous outbreaks of two or more diseases like scrub typhus, dengue fever, malaria, leptospirosis and chikungunya during monsoon and post-monsoon period, sharing common indication of acute febrile illness. The objective of the present study was to assess the prevalence of coinfections among patients with acute undifferentiated fevers (AUF) admitted in a tertiary care hospital in the northern hilly state of Himachal Pradesh, India.

Methods: This was a hospital based open cohort study conducted over a period of two months (September and October) in 2016. Read More

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http://www.jvbd.org/text.asp?2018/55/2/130/242560
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http://dx.doi.org/10.4103/0972-9062.242560DOI Listing
December 2018
4 Reads

Haemolysin Sph2 of Leptospira interrogans induces cell apoptosis via intracellular reactive oxygen species elevation and mitochondrial membrane injury.

Cell Microbiol 2019 Jan 19;21(1):e12959. Epub 2018 Oct 19.

Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.

Leptospira interrogans causes widespread leptospirosis in humans and animals, with major symptoms of jaundice and haemorrhage. Sph2, a member of the sphingomyelinase haemolysins, is an important virulence factor for leptospire. In this study, the function and mechanism of Sph2 in the pathogenesis of leptospirosis were investigated to further understand the pathogenesis of leptospire. Read More

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http://dx.doi.org/10.1111/cmi.12959DOI Listing
January 2019
4 Reads

Dealing with leptospirosis in dogs.

Authors:
Kate Murphy

Vet Rec 2018 Sep;183(12):384-385

IDEXX Laboratories, Grange House, Sandbeck Way, Wetherby, West Yorkshire LS22 7DN.

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http://dx.doi.org/10.1136/vr.k4093DOI Listing
September 2018

Genetic diversity of Leptospira interrogans circulating isolates and vaccine strains in China from 1954-2014.

Hum Vaccin Immunother 2019 12;15(2):381-387. Epub 2018 Oct 12.

c Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products , National Institutes for Food and Drug Control , Beijing , People's Republic of China.

Leptospirosis is one of the most important but neglected, infectious tropical diseases worldwide. Leptospira interrogans is now recognized as a leading cause of the disease. Little is known of the genetic diversity and phylogenetic characteristics of L. Read More

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http://dx.doi.org/10.1080/21645515.2018.1528839DOI Listing
October 2018
4 Reads

Development and evaluation of monoclonal antibody-based antigen capture enzyme-linked immunosorbent assay for the diagnosis of acute leptospirosis in humans.

J Immunol Methods 2018 Dec 12;463:134-136. Epub 2018 Sep 12.

Laboratory of Infectious Diseases, Department of Microbiology, Graduate School of Medicine, Hokkaido University, Japan.

Monoclonal antibody (MAb)-based ELISA was developed to detect leptospiral antigens from the plasma of febrile patients. The MAb reacts specifically with pathogenic leptospires and the assay possesses excellent diagnostic test parameters compared to PCR, indicating that this new ELISA is useful for the early diagnosis of leptospirosis with low operational cost. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00221759183028
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http://dx.doi.org/10.1016/j.jim.2018.09.006DOI Listing
December 2018
17 Reads

Detection of pathogenic Leptospira in ornamental water fountains from urban sites in Cali, Colombia.

Int J Environ Health Res 2019 Feb 14;29(1):107-115. Epub 2018 Sep 14.

b Department of Microbiology, School of Basic Sciences , Universidad del Valle , Cali , Colombia.

Leptospirosis is a disease endemic to both rural and urban areas of tropical countries and resource-poor communities. Little information is available on the presence of Leptospira spp. in urban water sources. Read More

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http://dx.doi.org/10.1080/09603123.2018.1519526DOI Listing
February 2019
13 Reads
1.513 Impact Factor

Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis.

PLoS Negl Trop Dis 2018 09 13;12(9):e0006694. Epub 2018 Sep 13.

Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay.

Leptospirosis is a neglected zoonosis with worldwide distribution. The causative agents are spirochete bacteria of the Leptospira genus, displaying huge diversity of serovars, the identity of which is critical for effective diagnosis and vaccination purposes. Among many other mammalian species, Leptospira infects cattle, eliciting acute signs in calves, and chronic disease in adult animals often leading to abortions. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136691PMC
September 2018
5 Reads

A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas.

Infect Dis Poverty 2018 Sep 3;7(1):87. Epub 2018 Sep 3.

University of Montreal Public Health Research Institute (IRSPUM), Montreal, Canada.

Background: Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings. There is a need to know what rapid diagnostic technologies are available, have been properly assessed, and are being implemented to improve control of these diseases in the urban context. This paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty. Read More

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http://dx.doi.org/10.1186/s40249-018-0474-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120097PMC
September 2018
15 Reads

Leptospirosis in pregnancy: A lesson in subtlety.

Malays J Pathol 2018 Aug;40(2):169-173

University Teknologi MARA, Faculty of Medicine, Centre for Diagnostic & Research Laboratories, Selangor, Malaysia.

Introduction: Leptospirosis is a zoonotic disease caused by spirochaete of the genus Leptospira. Human infection occurs after exposure to water or soil contaminated by urine from an infected animal. Most patients manifest as self-limited systemic illness. Read More

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August 2018
10 Reads

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins.

Cell Microbiol 2019 Feb 26;21(2):e12949. Epub 2018 Sep 26.

Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France.

Pathogenic Leptospira bacteria are the causative agents of leptospirosis, a zoonotic disease affecting animals and humans worldwide. These pathogenic species have the ability to rapidly cross host tissue barriers by a yet unknown mechanism. A comparative analysis of pathogens and saprophytes revealed a higher abundance of genes encoding proteins with leucine-rich repeat (LRR) domains in the genomes of pathogens. Read More

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http://doi.wiley.com/10.1111/cmi.12949
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http://dx.doi.org/10.1111/cmi.12949DOI Listing
February 2019
10 Reads

Fine-scale GPS tracking to quantify human movement patterns and exposure to leptospires in the urban slum environment.

PLoS Negl Trop Dis 2018 08 31;12(8):e0006752. Epub 2018 Aug 31.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.

Background: Human movement is likely an important risk factor for environmentally-transmitted pathogens. While epidemiologic studies have traditionally focused on household risk factors, individual movement data could provide critical additional information about risk of exposure to such pathogens. We conducted global positioning system (GPS) tracking of urban slum residents to quantify their fine-scale movement patterns and evaluate their exposures to environmental sources of leptospirosis transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143277PMC
August 2018
14 Reads

Update on the status of leptospirosis in New Zealand.

Acta Trop 2018 Dec 27;188:161-167. Epub 2018 Aug 27.

AUT - Roche Diagnostics Laboratory, School of Applied Sciences, Auckland University of Technology, Auckland, New Zealand.

Leptospirosis is a zoonotic disease that poses public health and ecological threats worldwide. In New Zealand (NZ), incidence of the disease is relatively high compared to other developed countries. The aim of this review was to describe the epidemiological status, ecological risk of leptospirosis and prevention in NZ. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.08.021DOI Listing
December 2018
15 Reads
2.270 Impact Factor

Evaluation of BOX-PCR and ERIC-PCR as Molecular Typing Tools for Pathogenic .

Dis Markers 2018 1;2018:1351634. Epub 2018 Aug 1.

Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia.

In the last decades, leptospirosis had gained public health concern due to morbidity and mortality rates caused by pathogenic . The need for rapid and robust molecular typing methods to differentiate this zoonotic pathogen is of utmost importance. Various studies had been conducted to determine the genetic relatedness of isolates using molecular typing methods. Read More

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http://dx.doi.org/10.1155/2018/1351634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092967PMC
December 2018
1 Read

Molecular characterization of pathogenic Leptospira sp. in small mammals captured from the human leptospirosis suspected areas of Selangor state, Malaysia.

Acta Trop 2018 Dec 23;188:68-77. Epub 2018 Aug 23.

Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. Electronic address:

Leptospirosis is caused by the spirochetal bacterium Leptospira of which rodents are considered the most important reservoir. This study aims to determine and characterize virulent Leptospira species among rodents and small mammals found in human settlements and recreational spots within the Hulu Langat and Gombak districts of Selangor, Malaysia; regions that frequently report probable human leptospirosis cases. Molecular analysis revealed an overall Leptospira detection rate of 14. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183081
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http://dx.doi.org/10.1016/j.actatropica.2018.08.020DOI Listing
December 2018
5 Reads

Determinants of clinical leptospirosis in Nepal.

Zoonoses Public Health 2018 12 24;65(8):972-983. Epub 2018 Aug 24.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Leptospirosis is an important zoonotic disease in Nepal; however, there is a lack of information on sources of leptospirosis infection for people and associated risk factors. We implemented a case-control study nested within a cross-sectional survey to investigate zoonotic risks of human leptospirosis among adult, febrile patients seeking treatment in healthcare centres in Kaski District, Nepal, from April to October 2013. The study population was 239 febrile patients; the data consisted of paired blood samples; questionnaires on clinical symptoms; occupational, environmental and animal exposures; and a blood sample from animals in the household. Read More

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http://dx.doi.org/10.1111/zph.12516DOI Listing
December 2018
20 Reads

Geographic distribution of anti-Leptospira antibodies in humans in Côte d'Ivoire, West Africa.

Eur J Clin Microbiol Infect Dis 2018 Nov 20;37(11):2177-2180. Epub 2018 Aug 20.

Institut Pasteur de Côte d'Ivoire, 08 B.P. 919, Abidjan, 08, Côte d'Ivoire.

Leptospirosis is a zoonotic bacterial disease with a worldwide importance, mostly frequent in tropical and subtropical countries. In Côte d'Ivoire, little is known about leptospirosis and human data are sparse. This disease is usually misdiagnosed with other febrile illnesses, and determining high-risk areas could allow better management of this disease, leading to policies. Read More

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http://dx.doi.org/10.1007/s10096-018-3359-7DOI Listing
November 2018
1 Read

Aetiology of acute febrile illness: a multicentre study from the province of Kerala in southern India.

Trop Doct 2018 Oct 20;48(4):322-325. Epub 2018 Aug 20.

2 Professor of Medicine, M.O.S.C Medical College & Hospital, Kolenchery, Kerala, India.

Acute febrile illness with varied aetiology but similar symptoms is common in tropical countries. This prospective, multicentre study was conducted in selected centres in the province of Kerala in India principally to analyse the aetiology of acute febrile illnesses in adult patients over the course of one year. Overall, 1324 patients were included in the study. Read More

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http://dx.doi.org/10.1177/0049475518794572DOI Listing
October 2018
17 Reads

Leptospirosis: a diagnostic conundrum.

Trop Doct 2018 Oct 19;48(4):306-309. Epub 2018 Aug 19.

4 Professor, Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Leptospirosis is a serious public health concern worldwide. It is highly endemic in the Andaman Islands and its prevalence is increasing in other Indian states. Clinical features are non-specific and diagnosis relies on laboratory confirmation. Read More

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http://dx.doi.org/10.1177/0049475518788470DOI Listing
October 2018
12 Reads

Proteomic Analysis of Urine from California Sea Lions ( Zalophus californianus): A Resource for Urinary Biomarker Discovery.

J Proteome Res 2018 Sep 28;17(9):3281-3291. Epub 2018 Aug 28.

Hollings Marine Laboratory , College of Charleston , Charleston , South Carolina 29412 , United States.

Urinary markers for the assessment of kidney diseases in wild animals are limited, in part, due to the lack of urinary proteome data, especially for marine mammals. One of the most prevalent kidney diseases in marine mammals is caused by Leptospira interrogans, which is the second most common etiology linked to stranding of California sea lions ( Zalophus californianus). Urine proteins from 11 sea lions with leptospirosis kidney disease and eight sea lions without leptospirosis or kidney disease were analyzed using shotgun proteomics. Read More

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http://dx.doi.org/10.1021/acs.jproteome.8b00416DOI Listing
September 2018
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Temporal analysis of the relationship between leptospirosis, rainfall levels and seasonality, Santa Catarina, Brazil, 2005-2015.

Rev Inst Med Trop Sao Paulo 2018 Jul 30;60:e39. Epub 2018 Jul 30.

Universidade do Sul de Santa Catarina, Programa de Pós-Graduação em Ciências da Saúde, Palhoça, Santa Catarina, Brazil.

The objective of the study is to analyze the temporal trend of leptospirosis incidence, according to rainfall levels in Santa Catarina, according to seasonality, from 2005 to 2015. This is an ecological study of time series, with date of leptospirosis, rainfall levels and population. The incidence rates of leptospirosis, relative excess of incidence, Pearson's correlation coefficient (r) and an angular coefficient (β) were analyzed from the linear regression adjustment, with a 5% significance level. Read More

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http://dx.doi.org/10.1590/S1678-9946201860039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069269PMC

Simplified MLST scheme for direct typing of Leptospira human clinical samples.

Pathog Glob Health 2018 06 31;112(4):203-209. Epub 2018 Jul 31.

a Biotechnology Institute , National Institute of Agropecuarian Technology (INTA) , Hurlingham , Buenos Aires , Argentina.

Leptospirosis is a globally distributed zoonosis. Epidemiological data are scarce and present major challenge because of the varied clinical presentations. Multilocus Sequence Typing has already proven to be a robust molecular typing method providing accurate results for strain characterization. Read More

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https://www.tandfonline.com/doi/full/10.1080/20477724.2018.1
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http://dx.doi.org/10.1080/20477724.2018.1480137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147079PMC
June 2018
12 Reads

A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway.

Emerg Microbes Infect 2018 Jul 31;7(1):135. Epub 2018 Jul 31.

Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

Leptospira interrogans is the major causative agent of leptospirosis, an emerging, globally spreading zoonotic infectious disease. The pathogen induces macrophage apoptosis, but the molecular basis and mechanism remain unknown. In the present study, we found that L. Read More

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http://dx.doi.org/10.1038/s41426-018-0135-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066479PMC
July 2018
1 Read

Characterization of the clonal subpopulation Fiocruz L1-130 of Leptospira interrogans in rats and dogs from Brazil.

J Med Microbiol 2018 Sep 30;67(9):1361-1367. Epub 2018 Jul 30.

1​Laboratory of Veterinary Bacteriology, Department of Microbiology and Parasitology, Universidade Federal Fluminense, Niterói, RJ, Brazil.

Purpose: Leptospira interrogans serogroup Icterohaemorrhagiae strains have been described as causing disease in both humans and animals and as being present worldwide. Icterohaemorrhagiae and Copenhageni serovars are known to cause severe disease in their hosts, and zoonotic outbreaks have been described. The genetic similarity among the strains of these serovars is known. Read More

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http://dx.doi.org/10.1099/jmm.0.000806DOI Listing
September 2018

Antimicrobial Resistance in , , and Other Rarely Investigated Veterinary and Zoonotic Pathogens.

Microbiol Spectr 2018 07;6(4)

School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.

, , and are major agents of zoonotic disease, causing high morbidity and, in some cases, significant mortality in humans. For all three genera, prompt diagnosis and appropriate antimicrobial therapy are required to prevent the development of chronic, debilitating illness. spp. Read More

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http://dx.doi.org/10.1128/microbiolspec.ARBA-0029-2017DOI Listing

Isolation and characterization of Leptospira interrogans from two patients with leptospirosis in Western Province, Sri Lanka.

J Med Microbiol 2018 Sep 19;67(9):1249-1252. Epub 2018 Jul 19.

2​Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Leptospirosis is an endemic infectious disease causing considerable morbidity and mortality in Sri Lanka; however, reports on the isolation of Leptospira from infected patients in Sri Lanka have been largely unavailable since the 1970s. Two isolates were obtained and characterized from 100 blood cultures from leptospirosis-suspected patients. Phylogenic analysis of partial flaB gene sequences identified the isolates as Leptospira interrogans. Read More

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http://dx.doi.org/10.1099/jmm.0.000800DOI Listing
September 2018

A qualitative exploration of the misconceptions, knowledge gaps and constructs of leptospirosis among rural and urban communities in Malaysia.

PLoS One 2018 18;13(7):e0200871. Epub 2018 Jul 18.

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

This qualitative study aimed to explore the misconceptions, knowledge gaps and constructs of leptospirosis among 72 respondents from rural and urban districts in two states of Malaysia. We conducted focus group discussions and data were examined using thematic analyses. The layman term of 'rat urine disease' contributed the most to the misconceptions regarding leptospirosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200871PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051666PMC
January 2019
19 Reads

Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.

Infection 2018 Dec 17;46(6):847-853. Epub 2018 Jul 17.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

To determine epidemiological, clinical and laboratory characteristics of leptospirosis, 24 consecutive patients diagnosed with the infection between 2011 and 2017 at the University Medical Center Hamburg-Eppendorf were retrospectively analyzed. The majority of patients were male travelers who returned from Southeast Asia and had a history of freshwater-associated activities. Considering the lack of discriminatory clinical or clinical chemistry parameters, leptospirosis should be regarded as differential diagnosis in any patient with acute febrile illness, especially with a history of travel to tropical and subtropical regions or freshwater exposure. Read More

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http://dx.doi.org/10.1007/s15010-018-1181-xDOI Listing
December 2018
1 Read

Study on causes of fever in primary healthcare center uncovers pathogens of public health concern in Madagascar.

PLoS Negl Trop Dis 2018 07 16;12(7):e0006642. Epub 2018 Jul 16.

Virology Unit, Institut Pasteur de Madagascar 101, Antananarivo, Madagascar.

Background: The increasing use of malaria diagnostic tests reveals a growing proportion of patients with fever but no malaria. Clinicians and health care workers in low-income countries have few tests to diagnose causes of fever other than malaria although several diseases share common symptoms. We propose here to assess etiologies of fever in Madagascar to ultimately improve management of febrile cases. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062140PMC
July 2018
1 Read

Sero-prevalence of leptospirosis and differentiation in blood parameters between positive and negative cases in dogs of Kathmandu Valley.

Trans R Soc Trop Med Hyg 2018 Aug;112(8):378-382

National Zoonoses and Food Hygiene Research Centre, Kalimati.

Background: Leptospirosis is a zoonotic disease with worldwide distribution. It affects both humans and animals. Dogs may serve as a sentinel as well as a potential carrier for Leptospira infection in human. Read More

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http://dx.doi.org/10.1093/trstmh/try065DOI Listing
August 2018
3 Reads