10,856 results match your criteria Leptospirosis


Endothelial biomarkers as predictors for hemodialysis need in severe leptospirosis patients (Weil's disease).

Trop Med Int Health 2022 Jun 27. Epub 2022 Jun 27.

Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, Brazil.

Objective: To investigate the prediction ability of vascular injury biomarkers for hemodialysis requirement in patients with severe leptospirosis.

Methods: Prospective study with severe leptospirosis patients hospitalized in Fortaleza, Brazil. Blood samples were collected at hospital admission to quantify vascular injury biomarkers: syndecan-1, ICAM-1, VCAM-1, angiopoietin-2 and FGF-23. Read More

View Article and Full-Text PDF

Replacement of in vivo leptospirosis vaccine potency testing in the United States.

Biologicals 2022 Jun 23. Epub 2022 Jun 23.

PETA Science Consortium International e.V, Friolzheimer Str. 3, 70499, Stuttgart, Germany.

The U.S. Department of Agriculture (USDA) regulates the potency testing of leptospirosis vaccines, which are administered to animals to protect against infection by Leptospira bacteria. Read More

View Article and Full-Text PDF

Canine leptospirosis in Canada, test-positive proportion and risk factors (2009 to 2018): A cross-sectional study.

PLoS One 2022 24;17(6):e0270313. Epub 2022 Jun 24.

Baltimore Department of Health, Baltimore, MD, United States of America.

Over the past decade, there has been an apparent increased frequency and widened distribution of canine leptospirosis in Canada, however, this has been minimally investigated. Availability and clinical uptake of Leptospira polymerase chain reaction (PCR)-based testing of dogs in Canada may provide important insight into the epidemiology of this canine and zoonotic infectious disease. Study objectives were to evaluate clinical canine Leptospira PCR test results from a large commercial laboratory to determine temporal and spatial distribution in Canada and identify dog, geographic and temporal risk factors for test-positive dogs. Read More

View Article and Full-Text PDF

Impact of Plantation Induced Forest Degradation on the Outbreak of Emerging Infectious Diseases-Wayanad District, Kerala, India.

Int J Environ Res Public Health 2022 Jun 8;19(12). Epub 2022 Jun 8.

Madhya Pradesh Rurban Mission, Government of India, Bhopal 462030, India.

The world has been facing a pandemic owing to COVID-19. We have also seen the geographic expansion and outbreaks of other emerging infectious diseases (EID) in recent years. This paper investigates the direct and indirect effects of land use land cover change (LULCC) on EID outbreaks in the context of Wayanad District of Kerala, India. Read More

View Article and Full-Text PDF

Diagnosis of Human Leptospirosis: Comparison of Microscopic Agglutination Test with Recombinant LigA/B Antigen-Based In-House IgM Dot ELISA Dipstick Test and Latex Agglutination Test Using Bayesian Latent Class Model and MAT as Gold Standard.

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Institute of Chemistry, Academia Sinica, Taipei 115024, Taiwan.

Leptospirosis is a spirochaetal infection that possesses a broad host range affecting almost all mammals. In the present study, the microscopic agglutination test (MAT) was compared with recombinant LigA/B antigen-based point-of-care diagnostics such as the in-house IgM dot ELISA dipstick test (IgM- DEDT) and the latex agglutination test (LAT) for the serodiagnosis of human leptospirosis. The comparison of the MAT with these two point-of-care diagnostics was performed using the MAT as the gold standard test and using Bayesian latent class modelling (BLCM), which considers all diagnostic tests as imperfect. Read More

View Article and Full-Text PDF

Bovine genital leptospirosis: Evidence of ovarian infection by Leptospira interrogans.

Vet Microbiol 2022 Jun 6;271:109489. Epub 2022 Jun 6.

Laboratório de Bacteriologia Veterinária, Instituto Biomédico, Niterói, Universidade Federal Fluminense, Alameda Barros Terra, 57, Niterói, RJ CEP: 24020-150, Brazil. Electronic address:

Leptospirosis in ruminants causes reproductive failures leading to important economic losses. This study assessed the occurrence and genetically identified Leptospira spp. in the follicular fluid (FF) of naturally infected live cows. Read More

View Article and Full-Text PDF

The Relevance of Screening for Vector-Borne Diseases in Dogs with Proteinuria Living in an Endemic Region: A Retrospective Study.

Vet Sci 2022 Jun 1;9(6). Epub 2022 Jun 1.

CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.

This study aims to assess the main causes of proteinuria in dogs from the region of Lisbon (Portugal), estimating the relevance of screening for canine vector-borne diseases (CVBDs). A cross-sectional retrospective study was conducted. Medical records from proteinuric dogs (urinary protein-creatinine ratio > 0. Read More

View Article and Full-Text PDF

Pathogenic Species in Bats: Molecular Detection in a Colombian Cave.

Trop Med Infect Dis 2022 May 27;7(6). Epub 2022 May 27.

Grupo de Enfermedades Infecciosas, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.

Leptospirosis is caused by pathogenic spp., which can be found in nature among domestic and wild animals. In Colombia, the Macaregua cave is known for its bat richness; thus, because bats are reservoir hosts of human microbiological pathogens, we determined if the Macaregua cave bats harbored in the wild. Read More

View Article and Full-Text PDF

Vector-Borne Diseases amidst COVID-19 Pandemic in India - A Mini-Review.

Maedica (Bucur) 2022 Mar;17(1):201-204

Department of Medicine, ESIC Medical College & Hospital, Hyderabad, India.

Vector-borne diseases are infections caused by parasites, viruses and bacteria and transmitted by vectors, which are usually insects. A greater risk of diseases such as dengue, malaria, seasonal influenza, leptospirosis, chikungunya, enteric fever, etc co-exist in COVID-19 cases. This poses challenges in clinical and laboratory diagnosis of COVID-19, which may affect clinical management and patient outcomes. Read More

View Article and Full-Text PDF

Original Leptospira spp. in island native terrestrial mammals: a case study in Pteropus spp. bats of New Caledonia.

Transbound Emerg Dis 2022 Jun 22. Epub 2022 Jun 22.

Institut Pasteur in New Caledonia, Leptospirosis Research and Expertise Unit.

Leptospirosis is a bacterial zoonosis that occurs in tropical and subtropical regions worldwide. Chiroptera are known to be a formidable reservoir of zoonotic pathogens, including leptospires. The epidemiology of leptospirosis in bats in the Pacific Islands is poorly known, both in terms of prevalence and in terms of the bacterial strains involved. Read More

View Article and Full-Text PDF

Canine leptospirosis in stray and sheltered dogs: a systematic review.

Anim Health Res Rev 2022 Jun 21:1-20. Epub 2022 Jun 21.

Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, Minas Gerais, Brazil.

The aim of this systematic review was to investigate the prevalence of leptospirosis among stray and sheltered dogs worldwide. Six databases were searched, which resulted in the retrieval of 476 articles. Sixty articles were selected for analysis according to 10 quality criteria. Read More

View Article and Full-Text PDF

A Novel Breakthrough in spp. Mutagenesis: Knockout by Combination of CRISPR/Cas9 and Non-homologous End-Joining Systems.

Front Microbiol 2022 26;13:915382. Epub 2022 May 26.

Laboratorio de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.

Leptospirosis is of general concern as it is a widespread zoonotic disease caused by pathogenic species of the genus , although this genus also includes free-living saprophytic strains. Understanding the pathophysiology of leptospirosis is still in its infancy even after several years of its discovery, because of the lack of effective genetic tools. The use of the CRISPR/Cas9 system and its variations have pushed the leptospirosis research forward, relying on the simplicity of the technique. Read More

View Article and Full-Text PDF

Clinical evaluation of the BioFire Global Fever Panel for the identification of malaria, leptospirosis, chikungunya, and dengue from whole blood: a prospective, multicentre, cross-sectional diagnostic accuracy study.

Lancet Infect Dis 2022 Jun 15. Epub 2022 Jun 15.

Universidad Nacional Autónoma de Honduras, Centro de Investigaciones Geneticas, Instituto de Investigacion en Microdbiologia, Tegucigalpa, Honduras.

Background: Acute febrile illness is a common presentation for patients at hospitals globally. Assays that can diagnose a variety of common pathogens in blood could help to establish a diagnosis for targeted disease management. We aimed to evaluate the performance of the BioFire Global Fever Panel (GF Panel), a multiplex nucleic acid amplification test performed on whole blood specimens run on the BioFire FilmArray System, in the diagnosis of several pathogens that cause acute febrile illness. Read More

View Article and Full-Text PDF

[Diagnostic protocol for febrile syndrome of respiratory origin in geographical areas of endemic risk of tropical infections].

Medicine (Madr) 2022 Jun 9;13(58):3432-3437. Epub 2022 Jun 9.

Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia.

The syndromic surveillance of a group of diseases that have similar signs and symptoms, a common pathophysiology, and diverse etiology is aimed at rapidly detecting the presence of outbreaks which could potentially harm public health. This includes not only known outbreaks of infectious origin but also those of unknown origin. In patients suspected of having SARS-CoV-2/COVID-19, it is recommended to consider other etiologies of tropical fever in the differential diagnosis when these patients live in or come from endemic areas, as is the case of dengue, malaria, leptospirosis, acute Chagas disease, and rickettsiosis, among other endemic diseases. Read More

View Article and Full-Text PDF

Development of a highly sensitive nucleic acid amplification-based detection for human leptospirosis infection.

Biotechniques 2022 Jun 14. Epub 2022 Jun 14.

Faculty of Medical Technology, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Highly sensitive diagnostic tools are crucial for individual screening during an epidemic of leptospirosis. To aid in developing a diagnostic tool for the sensitive detection of pathogenic strains, a new approach targeting nucleic acid amplification that combines quantitative PCR (qPCR) and strand displacement isothermal amplification was evaluated. The effectiveness of the combined approach, a quantitative polymerase chain displacement reaction (qPCDR), was compared with a qPCR technique. Read More

View Article and Full-Text PDF

Estimating the duration of antibody positivity and likely time of Leptospira infection using data from a cross-sectional serological study in Fiji.

PLoS Negl Trop Dis 2022 Jun 13;16(6):e0010506. Epub 2022 Jun 13.

Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Leptospirosis is a zoonotic disease prevalent throughout the world, but with particularly high burden in Oceania (including the Pacific Island Countries and Territories). Leptospirosis is endemic in Fiji, with outbreaks often occurring following heavy rainfall and flooding. As a result of non-specific clinical manifestation and diagnostic challenges, cases are often misdiagnosed or under-ascertained. Read More

View Article and Full-Text PDF

Unique Posttranslational Modification Sites of Acetylation, Citrullination, Glutarylation, and Phosphorylation Are Found to Be Specific to the Proteins Partitioned in the Triton X-114 Fractions of .

ACS Omega 2022 Jun 25;7(22):18569-18576. Epub 2022 May 25.

ICMR-Regional Medical Research Centre, Port Blair 744103, Andaman and Nicobar Islands, India.

Posttranslational modifications (PTMs) are decisive factors in the structure, function, and localization of proteins in prokaryotic and eukaryotic organisms. However, prokaryotic organisms lack subcellular organelles, and protein localization based on subcellular locations like cytoplasm, inner membrane, periplasm, and outer membrane can be accounted for functional characterization. We have identified 131 acetylated, 1182 citrullinated, 72 glutarylated, 5 palmitoylated, and 139 phosphorylated proteins from Triton X-114 fractionated proteins of , the pathogen of re-emerging zoonotic disease leptospirosis. Read More

View Article and Full-Text PDF

Predictors of lethality in severe leptospirosis in Transcarpathian region of Ukraine.

Infez Med 2022 1;30(2):272-276. Epub 2022 Jun 1.

Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine.

Leptospirosis is one of the most widespread zoonoses in the Transcarpathian region, with an average lethality of 12.5%. To determine the predictors of lethality, a retrospective study of 97 medical records of patients with leptospirosis in the period from 2009 to 2018 was conducted. Read More

View Article and Full-Text PDF

Effects of rainfall on human leptospirosis in Thailand: evidence of multi-province study using distributed lag non-linear model.

Authors:
Arthit Phosri

Stoch Environ Res Risk Assess 2022 Jun 4:1-14. Epub 2022 Jun 4.

Department of Environmental Health Sciences, Faculty of Public Health, Mahidol University, Bangkok, 10400 Thailand.

Leptospirosis is a zoonotic bacterial disease that remains an important public health problem, especially in tropical developing countries. Many previous studies in Thailand have revealed the outbreak of human leptospirosis after heavy rainfall, but research determining its quantitative risks associated with rainfall, especially at the national level, remains limited. This study aims to examine the association between rainfall and human leptospirosis across 60 provinces of Thailand. Read More

View Article and Full-Text PDF

The impact of genetic recombination on pathogenic Leptospira.

Infect Genet Evol 2022 Aug 7;102:105313. Epub 2022 Jun 7.

Institute for Integrative Systems Biology, University of Valencia, Valencia, Spain; Joint Research Unit "Infection and Public Health" FISABIO-University of Valencia, Valencia, Spain; CIBER (Centro de Investigación Biomédica en Red) in Epidemiology and Public Health, Valencia, Spain. Electronic address:

Leptospirosis is the most common zoonosis worldwide, and is increasingly common in poor urban communities, where there is inadequate sewage disposal and abundance of domestic and peridomestic animals. There are many risk factors associated with the disease, such as contaminated water exposure, close contact with animals, floods, recreational activities related to water, wet agriculture. The symptoms of leptospirosis are common to other infectious diseases and, if not treated, it can lead to meningitis, liver failure, kidney damage and death. Read More

View Article and Full-Text PDF

Infectious causes of acute encephalitis syndrome hospitalizations in Central India, 2018-20.

J Clin Virol 2022 May 28;153:105194. Epub 2022 May 28.

Kakatiya Medical College, Warangal, Telangana, India.

Background: We enhanced surveillance of hospitalizations of all ages for acute encephalitis syndrome (AES) along with infectious aetiologies, including the Japanese encephalitis virus (JEV).

Methods: From October 2018 to September 2020, we screened neurological patients for AES in all age groups in Maharashtra and Telangana States. AES cases were enrolled at study hospitals along with other referrals and sampled with cerebrospinal fluid, acute and convalescent sera. Read More

View Article and Full-Text PDF

Zoonotic pathogens and diseases detected in Vietnam, 2020-2021.

One Health 2022 Jun 13;14:100398. Epub 2022 May 13.

Food and Agriculture Organization of the United Nations (FAO), Country Office for Vietnam, Hanoi, Vietnam.

Vietnam has been identified as a country at high-risk for emergence and re-emergence of zoonotic diseases. The government of Vietnam recognized five priority zoonoses, including highly pathogenic avian influenza, rabies, leptospirosis, anthrax, and , and established a framework for One Health investigation and response to these diseases. From July 2020 to February 2021, quantitative data of zoonoses were collected from an online survey in 61 of 63 provinces based on either clinical diagnosis or laboratory confirmation. Read More

View Article and Full-Text PDF

Factors affecting preventive behavior against leptospirosis among the population at risk in Si Sa Ket, Thailand.

One Health 2022 Jun 13;14:100399. Epub 2022 May 13.

Tropical and Parasitic Diseases Research Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand.

Leptospirosis is a major public health problem in Si Sa Ket, Thailand. Humans can become infected direct contact with the urine of infected animal reservoir hosts or by indirect contact with contaminated soil and water in the environment. This study examined the factors affecting preventive behavior against leptospirosis among the population at risk in Si Sa Ket, Thailand. Read More

View Article and Full-Text PDF

Astragalus polysaccharides protects against acute leptospirosis by glycolysis-depended priming effect.

Biomed Pharmacother 2022 Jul 28;151:113198. Epub 2022 May 28.

Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, People's Republic of China. Electronic address:

Leptospirosis, caused by pathogenic leptospira, is a neglected infectious disease that causes acute kidney injury, bleeding disorders, and even death. People can become infected with leptospirosis when they travel into epidemic areas. Except for vaccines and antibiotics, there are few reports of other drugs about prevention of leptospirosis. Read More

View Article and Full-Text PDF

Serological and molecular characteristics of pathogenic Leptospira in rodent populations in Fujian Province, China, 2018-2020.

BMC Microbiol 2022 Jun 7;22(1):151. Epub 2022 Jun 7.

Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, China.

Background: Leptospirosis is a significant emerging infectious disease worldwide. Rodents are considered to be the most critical hosts of Leptospira spp. Fujian Province is a region highly endemic for leptospirosis in China. Read More

View Article and Full-Text PDF

Comparison of the Serion IgM ELISA and Microscopic Agglutination Test for diagnosis of Leptospira spp. infections in sera from different geographical origins and estimation of Leptospira seroprevalence in the Wiwa indigenous population from Colombia.

PLoS Negl Trop Dis 2022 Jun 6;16(6):e0009876. Epub 2022 Jun 6.

Medical Mission Institute, Wuerzburg, Germany.

Leptospirosis is among the most important zoonotic diseases in (sub-)tropical countries. The research objective was to evaluate the accuracy of the Serion IgM ELISA EST125M against the Microscopic Agglutination Test (MAT = imperfect reference test); to assess its ability to diagnose acute leptospirosis infections and to detect previous exposure to leptospires in an endemic setting. In addition, to estimate the overall Leptospira spp. Read More

View Article and Full-Text PDF

Acute kidney injury in leptospirosis: A country-level report.

Travel Med Infect Dis 2022 Jun 2;49:102359. Epub 2022 Jun 2.

Department of Infectious Diseases, University Hospital Center "Mother Theresa", Tirana, Albania.

View Article and Full-Text PDF

Leptospirosis in central & eastern Uttar Pradesh, an underreported disease: A prospective cross-sectional study.

Indian J Med Res 2022 Jun 1. Epub 2022 Jun 1.

Amity Institute of Biotechnology, Amity University, Lucknow, Uttar Pradesh, India.

Background & Objective: Leptospirosis is a zoonotic disease associated with potentially fatal consequences and a grossly underreported disease in Uttar Pradesh. However, only a few studies are available which report the prevalence of leptospirosis in this State. Hence, this study was undertaken to know the status of the disease in central and eastern Uttar Pradesh. Read More

View Article and Full-Text PDF

Serological and molecular epidemiology of leptospirosis and the role of dogs as sentinel for human infection in Nigeria.

Heliyon 2022 May 21;8(5):e09484. Epub 2022 May 21.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, United States.

Objective: Prospective cross-sectional study of dogs in Nigeria to study leptospirosis, inferred to be endemic in all regions of the country by researchers. Aim is to generate empirical updated evidence of leptospiral infection and delineate serovars involved.

Methods: Study determined the sero-prevalence and infection rate in 342 dogs using sero-assays, culture isolation and novel qPCR. Read More

View Article and Full-Text PDF

Population Structure of Curraleiro Pé-Duro Cattle and its Relationship With the Serological Profile Against Pathogens of Economic and Zoonotic Interest.

Front Genet 2022 13;13:872660. Epub 2022 May 13.

Department of Veterinary Medicine, School of Veterinary and Animal Science, Federal University of Goiás, Goiânia, Brazil.

Curraleiro Pé-Duro (CPD) cattle, a Brazilian local breed, are animals that are highly resistant to infectious and parasitic diseases. Strategies for the conservation of the breed and the genetic resistance to diseases should also consider the characteristics of the breed. The objective of this study was to analyze the diversity and population structure of the CPD breed using microsatellite markers and to correlate the serological profiles for causative agents of brucellosis, leptospirosis, neosporosis, leukosis, infectious bovine rhinotracheitis, and bovine viral diarrhea. Read More

View Article and Full-Text PDF