9,649 results match your criteria Leptospirosis


Endocytic recycling and vesicular transport systems mediate transcytosis of across cell monolayer.

Elife 2019 Apr 23;8. Epub 2019 Apr 23.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.

Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with -containing animal urine-contaminated water. The spirochetes invade internal organs after septicemia to cause disease aggravation, but the mechanism of leptospiral excretion and spreading remains unknown. Read More

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https://elifesciences.org/articles/44594
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http://dx.doi.org/10.7554/eLife.44594DOI Listing
April 2019
1 Read

Identification of Leptospira spp. from environmental sources in areas with high human leptospirosis incidence in the Philippines.

Pathog Glob Health 2019 Apr 22:1-8. Epub 2019 Apr 22.

a Institute of Biology, College of Science , University of the Philippines , Quezon City , Philippines.

Leptospira is the causative agent of leptospirosis, which is considered an emerging major threat to public health due to its increasing frequency reported worldwide. In the Philippines, the prevalence of the disease continuously rises, particularly in urban areas. Because leptospirosis is commonly transmitted through contact with contaminated environment, water and soil samples were collected in regions in the Philippines where high incidence of human leptospirosis cases was reported recently. Read More

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http://dx.doi.org/10.1080/20477724.2019.1607460DOI Listing

Evaluation of C-reactive protein and its kinetics as a prognostic indicator in canine leptospirosis.

J Small Anim Pract 2019 Apr 22. Epub 2019 Apr 22.

Division of Small Animal Internal Medicine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, 3001, Switzerland.

Objective: To evaluate C-reactive protein at presentation and during hospitalisation in dogs with acute kidney injury resulting from leptospirosis to compare C-reactive protein at presentation in dogs with acute kidney injury of different aetiology and to study its correlation with markers of inflammation, azotaemia and survival.

Materials And Methods: Prospective observational study of 41 dogs with acute kidney injury secondary to leptospirosis and 15 control dogs with acute kidney injury of different aetiology. C-reactive protein was measured at presentation in both groups and daily for 7 days in a subgroup of 28 dogs with leptospirosis. Read More

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http://dx.doi.org/10.1111/jsap.13004DOI Listing

Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil.

Res Vet Sci 2019 Apr 11;124:280-283. Epub 2019 Apr 11.

Fluminense Federal University, Laboratory of Veterinary Bacteriology, Biomedical Institute, 101 Prof. Hernani Mello Street, Niterói, Rio de Janeiro, Brazil. Electronic address:

Leptospirosis is an important worldwide zoonosis, caused by a bacterium of the genus Leptospira. For a better understanding of the disease, it is relevant the application of the one health concept. The Atlantic Forest is considered a biodiversity hotspot, with a great endemism of species and despite its importance and proximity to urban areas, the potential role of its fauna as carriers of infectious agents is still poorly understood. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.04.001DOI Listing

Severe Myasthenic Manifestation of Leptospirosis Associated with New Sequence Type of Leptospira interrogans.

Emerg Infect Dis 2019 May;25(5):968-971

We report the rapid development of a myasthenic crisis as the first-time manifestation of myasthenia gravis. The symptoms developed in the course of acute leptospirosis associated with a new sequence type of Leptospira interrogans. Antibiotic treatment led to rapid amelioration of myasthenia. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1591_article.htm
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http://dx.doi.org/10.3201/eid2505.181591DOI Listing
May 2019
1 Read

A Review of Four Cases of Leptospirosis Presenting for Acute Care to a Tertiary Paediatric Hospital in Singapore.

Ann Acad Med Singapore 2019 Mar;48(3):104-108

Department of Paediatrics, KK Women's and Children's Hospital, Singapore.

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March 2019
1.221 Impact Factor

Vaccine potential of LenA and LcpA proteins of in combination with heat-labile enterotoxin, B subunit (LTB).

Iran J Microbiol 2019 Feb;11(1):39-47

Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Leptospirosis is a zooanthroponosis caused by the genus of . It is an emerging public health problem due to its increasing incidence. The achievement to a vaccine that prevent from entrance of to the deeper tissues of the host is needed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462271PMC
February 2019

Systematic Review of Important Bacterial Zoonoses in Africa in the Last Decade in Light of the 'One Health' Concept.

Pathogens 2019 04 16;8(2). Epub 2019 Apr 16.

Infectious Diseases and Anti-Infective Therapy Research Group, Sharjah Medical Research Institute and College of Pharmacy, University of Sharjah, Sharjah 27272, UAE.

Zoonoses present a major public health threat and are estimated to account for a substantial part of the infectious disease burden in low-income countries. The severity of zoonotic diseases is compounded by factors such as poverty, living in close contact with livestock and wildlife, immunosuppression as well as coinfection with other diseases. The interconnections between humans, animals and the environment are essential to understand the spread and subsequent containment of zoonoses. Read More

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http://dx.doi.org/10.3390/pathogens8020050DOI Listing
April 2019
3 Reads

Prevention and control of leptospirosis in people and surveillance of the pathogenic Leptospira in rats and in surface water found at villages.

J Infect Public Health 2019 Apr 12. Epub 2019 Apr 12.

College of Medicine and Public Health, Ubon Ratchathani University, Warin Chamrap, Ubon Ratchathani, 34190, Thailand. Electronic address:

Background: Leptospirosis is a major public health problem in Thailand. This disease is caused by a Leptospira infection. Leptospira is found in rats and other animals that can contaminate soil and water resources. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.019DOI Listing

Health Risks of Flood Disasters.

Clin Infect Dis 2018 Oct;67(9):1450-1454

Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.

Floods are the most common natural disaster occurring worldwide, with their impact expected to grow in the future due to the effects of climate change and population shift. Floodwaters pose immediate dangers to human health, but also long-term effects resulting from displacement and worsened living conditions. This review examines the health impact of flood disasters, including skin and soft-tissue infections, gastroenteritis, and zoonotic infections such as leptospirosis, and the impact on noncommunicable diseases and health infrastructure. Read More

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http://dx.doi.org/10.1093/cid/ciy227DOI Listing
October 2018
3 Reads

Serological evidence of human leptospirosis in patients with acute undifferentiated febrile illness from Uttarakhand, India: A pilot study.

J Lab Physicians 2019 Jan-Mar;11(1):11-16

Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Context: To the best of our knowledge, there are no reports of serological evidence of human leptospirosis from Uttarakhand state in India.

Aims: The aim of this study was to screen for serological evidence of leptospirosis in patients with acute undifferentiated febrile illness at a tertiary care teaching hospital in Uttarakhand.

Settings And Design: A pilot study was conducted from March to November 2017. Read More

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http://dx.doi.org/10.4103/JLP.JLP_121_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437824PMC
April 2019
2 Reads

Polyphasic Rhabdomyositis in California Sea Lions ( Zalophus Californianus): Pathology and Potential Causes.

Vet Pathol 2019 Apr 14:300985819829526. Epub 2019 Apr 14.

3 The Marine Mammal Center, Sausalito, CA, USA.

A myositis syndrome has been recognized for more than a decade in California sea lions (CSLs; Zalophus californianus) but a detailed description of the lesions and potential causes of this condition is lacking. The tissues of 136 stranded CSLs with rhabdomyositis were examined. Rhabdomyositis was considered incidental in 67% (91/136) of the CSLs, and a factor contributing to the animal stranding (significant rhabdomyositis) in 33% (45/136). Read More

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http://journals.sagepub.com/doi/10.1177/0300985819829526
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http://dx.doi.org/10.1177/0300985819829526DOI Listing
April 2019
3 Reads

[Zoonoses related to leisure activities].

Authors:
Nadia Haddad

Rev Prat 2019 Mar;69(3):336-340

UMR BIPAR, Ecole nationale vétérinaire d'Alfort, Anses, INRA, université Paris-Est, Maisons- Alfort, France.

Zoonoses related to leisure activities. Many zoonoses can be contracted by humans during recreational activities. In the context of a walk, some of them, such as Lyme disease, are transmissible by biological vectors, particularly ticks, or by aerosol (Q fever, hantavirose), whereas others can be contracted in case of aquatic activities (leptospirosis), hunting (tularaemia), and visits to pet farms or fairs (especially the hemolytic uremic syndrome). Read More

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March 2019
3 Reads

Seroprevalence of leptospirosis in human groups at risk due to environmental, labor or social conditions.

Rev Argent Microbiol 2019 Apr 9. Epub 2019 Apr 9.

Bacteriology and Virology Department, Institute of Hygiene, Medicine Faculty, Universidad de la República, Uruguay.

Leptospirosis is important in Uruguay due to the economic loss caused by the diseases of production animals, mainly bovines, and also due to frequent human infection. We decided to study anti-Leptospira antibodies in the sera of dairy workers, rice laborers, veterinarians, suburban slum dwellers and garbage recyclers. Our aims were to estimate the seroprevalence of infection by Leptospira spp. Read More

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http://dx.doi.org/10.1016/j.ram.2019.01.005DOI Listing

Recreational 'mud fever': induced diffuse alveolar hemorrhage and severe acute respiratory distress syndrome in a U.S. Navy seaman following 'mud-run' in Hawaii.

IDCases 2019 23;15:e00529. Epub 2019 Mar 23.

University of Maryland School of Medicine, Baltimore, MD, United States.

A 23-year-old man with a viral-like prodrome developed sudden severe dyspnea and was found to have renal failure, anemia, shock, and diffuse alveolar hemorrhage with acute respiratory distress syndrome, requiring emergent endotracheal intubation and extracorporeal membrane oxygenation (ECMO). Travel and exposure history from peripheral sources revealed that the patient had participated in a 'mud-run' in Hawaii two weeks prior to symptom onset. The patient was subsequently diagnosed with leptospirosis and treated with ceftriaxone and doxycycline. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441746PMC
March 2019
3 Reads

Chronology of emergence of the genus Leptospira and over-representation of gene families enriched by vitamin B2, B12 biosynthesis, cell adhesion and external encapsulating structure in L. interrogans isolates from asymptomatic dogs.

Infect Genet Evol 2019 Apr 8;73:7-12. Epub 2019 Apr 8.

Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand; Diagnosis and Monitoring of Animal Pathogens Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand. Electronic address:

The spirochete species Leptospira interrogans is the most common cause of leptospirosis, producing acute to chronic infections in most mammalian species. This pathogenic bacterium has an ability to evolve in many ways to occupy various environments and hosts. In this study, we performed chronology analysis to look for insight into the emergence of Leptospira species, focusing on L. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.005DOI Listing
April 2019
2 Reads

Treatment of Hydropsical Conditions Using Transcervical Gradual Fetal Fluid Drainage in Mares With or Without Concurrent Abdominal Wall Disease.

J Equine Vet Sci 2018 May 27;64:81-88. Epub 2018 Feb 27.

Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada.

Hydropsical conditions are exceedingly rare in the horse. However, when they occur, they are true emergencies due to the severe enlargement of the pregnant uterus, which can result in clinical signs, such as an enlarged round abdomen, dyspnea, reluctance to walk, and colic, and may lead to the development of abdominal wall disease. The pathogenesis of hydropsical conditions is not fully elucidated, but they have been associated with placentitis and fetal abnormalities. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.02.021DOI Listing

Acute kidney injury management using intermittent low efficiency haemodiafiltration in a critical care unit: 39 dogs (2012-2015).

Acta Vet Scand 2019 Apr 10;61(1):17. Epub 2019 Apr 10.

Physiology Unit, Université de Lyon, VetAgro Sup, APCSe, 69280, Marcy l'Etoile, France.

Background: Veterinary studies describing acute kidney injury (AKI) management using renal replacement therapy (RRT) are limited and have primarily focused on intermittent haemodialysis in North American populations. European data are lacking, although differences in populations, pathogen and toxin exposure and RRT modalities may exist between Europe and North America. The present study reviewed RRT-managed cases from the intensive care unit (ICU) of VetAgro Sup, Lyon, France, for the period 2012-2015. Read More

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http://dx.doi.org/10.1186/s13028-019-0452-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457005PMC
April 2019
1 Read

Whole cell matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for identification of Leptospira spp. in Thailand and Lao PDR.

PLoS Negl Trop Dis 2019 04 10;13(4):e0007232. Epub 2019 Apr 10.

Proteomics Research Laboratory, National Center for Genetic Engineering and Biotechnology, Pathumthani, Thailand.

Leptospirosis is a zoonosis with a worldwide distribution, caused by pathogenic spirochetes of the genus Leptospira. The classification and identification of leptospires can be conducted by both genotyping and serotyping which are time-consuming and established in few reference laboratories. This study used matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as rapid and accurate tool for the identification of leptospires. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007232DOI Listing

[Animal and human bites : what to do and what to know ?]

Rev Med Suisse 2019 Apr;15(646):780-785

Service des maladies infectieuses, HUG, 1211 Genève 14.

Animal and human bites are a common cause of admission to the emergency room and the infections are common, although they are often trivialized. Complications can range from simple cellulitis to septic shock especially in asplenic patients with Capnoyctophaga canimorsus infection. Other less common infections are possible such as rat-bite fever, leptospirosis, tularemia, and evaluation of post-exposure prophylaxis (anti-tetanus, anti-rabies, HIV, HBV) is essential. Read More

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April 2019
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Molecular epidemiology of Leptospira interrogans in Rattus norvegicus in Hanoi, Vietnam.

Acta Trop 2019 Apr 6;194:204-208. Epub 2019 Apr 6.

Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Leptospirosis is a zoonotic disease that is caused by pathogenic spirochaetes of Leptospira spp. and it has become a public health concern in urban localities in the tropics. Rats are important reservoir animals for the transmission of leptospirosis in urban areas. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.008DOI Listing
April 2019
2 Reads

Diagnosis of Canine Leptospirosis.

Vet Clin North Am Small Anim Pract 2019 Apr 5. Epub 2019 Apr 5.

Department of Medicine and Epidemiology, University of California, 1 Shields Ave Davis, CA 95616, USA.

Several diagnostic tests are available to aid veterinarians in diagnosis of leptospirosis. Understanding the course of infection is imperative to determining which diagnostic test to order and sample to submit. Diagnostic tests for dogs suspected of having leptospirosis include antibody-based tests and polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1016/j.cvsm.2019.02.008DOI Listing

Leptospirosis in horses: A European perspective.

Authors:
F Malalana

Equine Vet J 2019 May;51(3):285-286

Institute of Veterinary Science, University of Liverpool, Neston, UK.

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http://dx.doi.org/10.1111/evj.13022DOI Listing

Epidemiological investigation of Leptospira spp. in a dairy farming enterprise after the occurrence of three human leptospirosis cases.

Zoonoses Public Health 2019 Apr 3. Epub 2019 Apr 3.

School of Veterinary Science, EpiCentre, Massey University, Palmerston North, New Zealand.

An epidemiological investigation was conducted in an unvaccinated dairy farming enterprise in which three workers on one of the milking herds (Herd 1) were diagnosed with leptospirosis due to serovars Hardjo (H) (n = 2) and Pomona (P) (n = 1) between January and March 2015. Blood and urine samples were collected from milking cows in Herd 1 (N = 230) and Herd 2 (N = 400), rising one- (R1, N = 125) and rising two-year-old (R2, N = 130) replacement heifers, and four pigs associated with Herd 1, in March 2015. Sera were tested using the MAT for serovars H, P, Copenhageni (C), Ballum (B) and Tarassovi (T), and urine samples were tested by qPCR. Read More

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http://dx.doi.org/10.1111/zph.12578DOI Listing
April 2019
1 Read

Leptospirosis in Campinas, São Paulo, Brazil: 2007-2014.

Rev Bras Epidemiol 2019 Apr 1;22:e190016. Epub 2019 Apr 1.

Faculdade de Ciências Médicas, Universidade Estadual de Campinas - Campinas (SP), Brasil.

Objective: to analyze the distribution of leptospirosis according to sociodemographic, epidemiologic, and clinical characteristics, assistance time, rainfall and spatial distribution in Campinas/SP in the period from 2007 to 2014.

Method: This is an ecological study using information from the confirmed cases. A descriptive analysis was carried out according to the selected variables. Read More

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http://dx.doi.org/10.1590/1980-549720190016DOI Listing

Doxycycline Usage for Prevention of Leptospirosis among Farmers and Reasons for Failure to Use Chemoprophylaxis: A Descriptive Study from Southern Sri Lanka.

J Trop Med 2019 3;2019:2917154. Epub 2019 Mar 3.

Department of Internal Medicine, University of Ruhuna, Sri Lanka.

Background: Leptospirosis causes substantial morbidity and mortality in Sri Lanka. Health authorities have implemented a chemoprophylaxis programme for prevention of disease for farmers who are at a high risk of leptospirosis. Only 39% of general population is aware of chemoprophylaxis. Read More

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http://dx.doi.org/10.1155/2019/2917154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420970PMC
March 2019
1 Read

Fatal visceral leishmaniosis in a dog caused by Leishmania infantum in Bosnia and Herzegovina: A case report.

Vet Parasitol Reg Stud Reports 2019 Jan 27;15:100260. Epub 2018 Dec 27.

Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.

Canine leishmaniosis (CanL) caused by Leishmania infantum, is a zoonotic vector-borne disease endemic in the Mediterranean region. Here, we report a molecularly confirmed case of fatal CanL caused by L. infantum in the south of Bosnia and Herzegovina where epidemiology data are scarce. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.100260DOI Listing
January 2019
3 Reads

Culture-attenuated pathogenic Leptospira lose the ability to survive to complement-mediated-killing due to lower expression of factor H binding proteins.

Microbes Infect 2019 Mar 25. Epub 2019 Mar 25.

Laboratorio de Inmunología Molecular, Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Av. Universidad 3000, Ciudad Universitaria, Coyoacán, C.P. 04510, Ciudad de México, Mexico. Electronic address:

Several pathogens including Gram-negative bacteria hijack complement regulators to escape host's innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of Leptospira, to bind Factor H. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.03.001DOI Listing

Leptospirosis incidence in a state capital in the Western Brazilian Amazon and its relationship with climate and environmental variability, 2008-2013.

Epidemiol Serv Saude 2019 03 21;28(1):e2017224. Epub 2019 Mar 21.

Universidade de São Paulo, Faculdade de Saúde Pública, São Paulo, SP, Brasil.

Objective: to analyze association between environmental variables and leptospirosis incidence in the municipality of Rio Branco, Acre, Brazil, 2008-2013.

Methods: this was an ecological study of association between monthly average environmental variables and monthly leptospirosis incidence, according to generalized autoregressive score models and moving averages.

Results: increases in the monthly average levels of the River Acre and days of precipitation per month were associated with a 7% increase (incidence rate ratio [RR] 1. Read More

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http://dx.doi.org/10.5123/S1679-49742019000100009DOI Listing

Environmental and socioeconomic determinants of leptospirosis incidence in Colombia.

Cad Saude Publica 2019 Mar 25;35(3):e00118417. Epub 2019 Mar 25.

Escuela de Economía y Administración, Universidad Industrial de Santander, Bucaramanga, Colombia.

Human leptospirosis is an infection that most often affects tropical countries. Since 2007, Colombia requires the notification of disease cases, enabling the observation of an increase in cases in recent years. The objectives of this article were to analyze environmental and socioeconomic variables and to evaluate their relationship with human leptospirosis cases. Read More

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http://dx.doi.org/10.1590/0102-311X00118417DOI Listing

High Prevalence of spp. in Rodents in an Urban Setting in Madagascar.

Am J Trop Med Hyg 2019 Mar 25. Epub 2019 Mar 25.

Plague Unit, WHO Collaborating Center, Institut Pasteur, Antananarivo, Madagascar.

Leptospirosis is a neglected zoonotic bacterial disease caused by pathogenic spp. Only limited studies have been conducted on the presence of spp. in rats in Antananarivo, the capital city of Madagascar. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0642DOI Listing
March 2019
1 Read

Three Strains From Western Indian Ocean Wildlife Show Highly Distinct Virulence Phenotypes Through Hamster Experimental Infection.

Front Microbiol 2019 11;10:382. Epub 2019 Mar 11.

Unité Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Université de La Réunion, INSERM 1187, CNRS 9192, IRD 249, Plateforme de Recherche CYROI, Sainte-Clotilde, Reunion, France.

Leptospirosis is one of the most widespread zoonoses worldwide, with highest incidence reported on tropical islands. Recent investigations carried out in a One-Health framework have revealed a wide diversity of pathogenic lineages on the different islands of Western Indian Ocean carried out by a large diversity of mammal reservoirs, including domestic and wild fauna. Using golden Syrian hamsters as a model of acute infection, we studied the virulence of and isolates obtained from rats, tenrecs, and bats, respectively. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421516PMC

Anti-microbial Activity of Aqueous Gall Extract against Pathogenic .

Malays J Med Sci 2018 Jul 30;25(4):42-50. Epub 2018 Aug 30.

School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: gall extract is known to have broad spectrum anti-microbial activity . This study was conducted to determine the anti-microbial activity of gall extract against pathogenic and to evaluate the morphological changes of extract-treated cells using a scanning electron microscope (SEM).

Methods: A two-fold serial microdilution broth assay was used to determine the minimum inhibitory concentration (MIC) of aqueous gall extract against the serovar Javanica and the serovar Icterohaemorrhagiae, at concentrations ranging from 4. Read More

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http://dx.doi.org/10.21315/mjms2018.25.4.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422538PMC

Myositis associated with A bacteremia appears to be common.

J Family Med Prim Care 2019 Jan;8(1):125-129

Department of Neurology, JIPMER, Puducherry, India.

Background: Fever and severe myalgia in a tropical country like India bring to mind leptospirosis, rickettsioses, dengue, and other viral fevers. Enteric fever is widely prevalent in Asia, but myositis has not been previously described in A bacteremia.

Materials And Methods: Retrospectively, we recruited patients with enteric fever admitted to our treating unit over a 6-month period. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_202_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396611PMC
January 2019
3 Reads

Factors Associated with Leptospirosis in Domestic Cattle in Salakphra Wildlife Sanctuary, Thailand.

Int J Environ Res Public Health 2019 Mar 22;16(6). Epub 2019 Mar 22.

Wildlife and Plant Research Center, Faculty of Environment and Resource Studies, Mahidol University, Nakhonpathom 73170, Thailand.

Leptospirosis found in cattle () has potentially increased in economic impact. The objective was to investigate the factors associated with leptospirosis in cattle in the protected area. We investigated the seroprevalence of leptospirosis in cattle in Salakphra Wildlife Sanctuary, Thailand. Read More

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http://dx.doi.org/10.3390/ijerph16061042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466321PMC

Characterization of CRISPR-Cas systems in Leptospira reveals potential application of CRISPR in genotyping of Leptospira interrogans.

APMIS 2019 Apr;127(4):202-216

Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.

Leptospirosis is a zoonotic disease caused by pathogenic Leptospira. However, understanding of the pathogenic mechanism of Leptospira is still elusive due to the limited number of genetic tools available for this microorganism. Currently, the reason for the genetic inaccessibility of Leptospira is still unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apm.12935
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http://dx.doi.org/10.1111/apm.12935DOI Listing
April 2019
7 Reads
1.922 Impact Factor

Leptospirosis in French Polynesia: 11 years of surveillance data, 2007-2017.

New Microbes New Infect 2019 May 14;29:100518. Epub 2019 Feb 14.

Bureau de veille sanitaire, Direction de la santé, Papeete, Tahiti, French Polynesia.

Leptospirosis is a worldwide zoonosis with higher incidence in tropical areas and is a neglected disease in the Pacific region. French Polynesia (FP) is a French overseas territory located in the South Pacific. Data on the epidemiology in FP are scarce. Read More

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http://dx.doi.org/10.1016/j.nmni.2019.100518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406075PMC

Guillain-Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection.

Trop Doct 2019 Mar 21:49475519836038. Epub 2019 Mar 21.

3 Consultant, Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

Guillain-Barré syndrome (GBS) is a potentially life-threatening immune-mediated acute inflammatory polyneuropathy associated with several antecedent infections. We report a 20-year-old man with GBS associated with concurrent leptospirosis and scrub typhus infection. GBS was confirmed with clinical examination and nerve conduction studies. Read More

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http://dx.doi.org/10.1177/0049475519836038DOI Listing
March 2019
1 Read

Antimicrobial Susceptibility Testing of spp. in the Lao People's Democratic Republic Using Disk Diffusion.

Am J Trop Med Hyg 2019 Mar 18. Epub 2019 Mar 18.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic.

Leptospirosis is a global zoonotic disease caused by pathogenic bacteria of the genus, which are fastidious, slow-growing organisms. Antimicrobial susceptibility data are limited; traditionally, the organisms have not been culturable on solid media. The recent development of Vanaporn Wuthiekanun (LVW) agar, which facilitates rapid growth of spp. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0955DOI Listing

An outbreak of leptospirosis with predominant cardiac involvement: a case series.

BMC Infect Dis 2019 Mar 18;19(1):265. Epub 2019 Mar 18.

Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.

Background: Severe leptospirosis is known to cause multi organ dysfunction including cardiac involvement. In the clinical setting with limited resources, high degree of suspicion is needed to diagnose cardiac involvement including myocarditis. Although myocarditis is not reported as a common complication due to lack of diagnostic facilities, there are evidence to support myocarditis is more prevalent in post mortem studies of patients died due to leptospirosis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3905-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423826PMC
March 2019
5 Reads

Clinical and biochemical differences between hantavirus infection and leptospirosis: a retrospective analysis of a patient series in Belgium.

Acta Clin Belg 2019 Mar 18:1-8. Epub 2019 Mar 18.

a Department of General Internal Medicine , UZ Leuven , Leuven , Belgium.

Objectives: Hantavirus infection and leptospirosis are infectious diseases transmitted by rodents. The clinical picture is nonspecific, often involving the kidneys but other organs can be affected too. Clinical and biochemical clues to make a difference between these two entities will be described. Read More

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http://dx.doi.org/10.1080/17843286.2019.1591654DOI Listing

Evaluation of a Rapid Kit for Detection of IgM against in Human.

Can J Infect Dis Med Microbiol 2019 7;2019:5763595. Epub 2019 Feb 7.

Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia.

Introduction: Leptospirosis is an acute febrile illness, known for its protean clinical manifestations and the challenge in differentiating from other infectious diseases. Standardized confirmatory test is antibody dependent and not accessible by the suburban community. This study measures efficiency of an immune-chromatographic assay, Leptocheck WB, in detecting acute leptospirosis. Read More

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http://dx.doi.org/10.1155/2019/5763595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383415PMC
February 2019

Epidemiology of Leptospira infection in livestock species in Saint Kitts.

Trop Anim Health Prod 2019 Mar 15. Epub 2019 Mar 15.

Ross University School of Veterinary Medicine, PO Box 334, Basseterre, West Indies, Saint Kitts and Nevis.

This pilot study describes the prevalence of Leptospira infection and exposure in livestock species, cattle, pig, sheep, and goats in Saint Kitts in the Caribbean region. Serum and kidney samples were collected from cattle, pigs, sheep, and goats at a local abattoir between September 2016 and March 2017. Cattle had the highest seroprevalence (79. Read More

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http://dx.doi.org/10.1007/s11250-019-01859-5DOI Listing

Probe-specific loop-mediated isothermal amplification magnetogenosensor assay for rapid and specific detection of pathogenic Leptospira.

Mol Cell Probes 2019 04 12;44:63-68. Epub 2019 Mar 12.

Department of Medical Microbiology & Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150, Kota Bharu, Kelantan, Malaysia. Electronic address:

This study highlighted the performance of the developed integrated loop-mediated isothermal amplification (LAMP) coupled with a colorimetric DNA-based magnetogenosensor. The biosensor operates through a DNA hybridization system in which a specific designed probe captures the target LAMP amplicons. We demonstrated the magnetogenosensor assay by detecting pathogenic Leptospira, which causes leptospirosis. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.03.001DOI Listing

Pathology and Host Immune Evasion During Human Leptospirosis: a Review.

Int Microbiol 2019 Mar 14. Epub 2019 Mar 14.

I Department of Medical Microbiology & Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

Human leptospirosis is considered as one of the most widespread and potentially fatal zoonotic diseases that causes high mortality and morbidity in the endemic regions of tropical and subtropical countries. The infection can arise from direct or indirect exposure of human through contaminated environment that contains leptospires or animal reservoirs that carry leptospires. The clinical manifestations during human leptospirosis ranges from asymptomatic, mild infections to severe and life-threatening complications involving multi-organ failures with kidneys, lungs and liver severely affected. Read More

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http://dx.doi.org/10.1007/s10123-019-00067-3DOI Listing

A novel diagnostic algorithm equipped on an automated hematology analyzer to differentiate between common causes of febrile illness in Southeast Asia.

PLoS Negl Trop Dis 2019 03 14;13(3):e0007183. Epub 2019 Mar 14.

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands.

Background: Distinguishing arboviral infections from bacterial causes of febrile illness is of great importance for clinical management. The Infection Manager System (IMS) is a novel diagnostic algorithm equipped on a Sysmex hematology analyzer that evaluates the host response using novel techniques that quantify cellular activation and cell membrane composition. The aim of this study was to train and validate the IMS to differentiate between arboviral and common bacterial infections in Southeast Asia and compare its performance against C-reactive protein (CRP) and procalcitonin (PCT). Read More

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http://dx.doi.org/10.1371/journal.pntd.0007183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435198PMC
March 2019
6 Reads

Louse-borne relapsing fever (Borrelia recurrentis infection).

Authors:
David A Warrell

Epidemiol Infect 2019 Jan;147:e106

Nuffield Department of Clinical Medicine,University of Oxford,Oxford,UK.

Louse-borne relapsing fever (LBRF) is an epidemic disease with a fascinating history from Hippocrates' times, through the 6th century 'Yellow Plague', to epidemics in Ireland, Scotland and England in the 19th century and two large Afro-Middle Eastern pandemics in the 20th century. An endemic focus persists in Ethiopia and adjacent territories in the Horn of Africa. Since 2015, awareness of LBRF in Europe, as a re-emerging disease, has been increased dramatically by the discovery of this infection in dozens of refugees arriving from Africa. Read More

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http://dx.doi.org/10.1017/S0950268819000116DOI Listing
January 2019
4 Reads

Feral cats do not play a major role in leptospirosis epidemiology on Reunion Island.

Epidemiol Infect 2019 Jan;147:e97

Université de La Réunion, UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical),INSERM 1187, CNRS 9192, IRD 249,Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion,France.

Although previous studies have reported Leptospira carriage in kidneys and urine of cats, the role of these animals in leptospirosis epidemiology remains poorly understood. Using molecular methods, we investigated Leptospira renal carriage in 172 feral cats from Reunion Island, an oceanic geographically isolated island located in the South West Indian Ocean. Only one out of the 172 analysed specimens tested positive for Leptospira DNA through quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1017/S0950268819000190DOI Listing
January 2019

Health monitoring during water scarcity in Mayotte, France, 2017.

BMC Public Health 2019 Mar 12;19(1):288. Epub 2019 Mar 12.

Santé publique France, cellule d'intervention en région océan Indien (CIRE OI) [French public health agency in the Indian Ocean Region], 2 bis avenue Georges Brassens CS 61002 - 97743 Saint-Denis cedex 9, Saint-Denis, La Réunion, France.

Background: During the 2016-2017 austral summer, unprecedented water scarcity was observed in the south of Mayotte, French island in the Indian Ocean. Therefore, authorities introduced restrictive measures to save the water of this part of the island. The rationing system affected over 65,000 people, for four months. Read More

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http://dx.doi.org/10.1186/s12889-019-6613-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416849PMC

Leptospiral phosphatidylinositol-specific phospholipase C: a novel conserved antigen for the definitive diagnosis of Leptospirosis.

Authors:
T H Samaha

Mol Biol Rep 2019 Mar 8. Epub 2019 Mar 8.

Regional Medical Research Centre (Indian Council of Medical Research), WHO Collaborating Centre for Diagnosis, Reference, Research and Training in Leptospirosis, Port Blair-744103, Andaman and Nicobar Islands, India.

Identification and characterisation of novel antigenic proteins of Leptospira are necessary to unravel the secrets of the Leptospiral disease biology. Besides, the current scenario of Leptospirosis demands the development of advanced diagnostics with the potential of an early and specific diagnosis. This work reports the diagnostic efficacy of a PI-PLC (LA_1375) of Leptospira interrogans serovar Lai strain 56601. Read More

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http://dx.doi.org/10.1007/s11033-019-04726-6DOI Listing