9,578 results match your criteria Leptospirosis


Values of diagnostic tests for the various species of spirochetes.

Med Mal Infect 2019 Feb 11. Epub 2019 Feb 11.

IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Aix Marseille Université, 13005 Marseille, France.

Bacteria of the Borrelia burgdorferi sensu lato complex, responsible for Lyme disease, are members of the spirochetes phylum. Diagnostic difficulties of Lyme disease are partly due to the characteristics of spirochetes as their culture is tedious or even impossible for some of them. We performed a literature review to assess the value of the various diagnostic tests of spirochetes infections of medical interest such as Lyme borreliosis, relapsing fever borreliae, syphilis, and leptospirosis. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.009DOI Listing
February 2019

A simple score to predict severe leptospirosis.

PLoS Negl Trop Dis 2019 Feb 13;13(2):e0007205. Epub 2019 Feb 13.

Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.

Background: The case-fatality rate of severe leptospirosis can exceed 50%. While prompt supportive care can improve survival, predicting those at risk of developing severe disease is challenging, particularly in settings with limited diagnostic support.

Methodology/principal Findings: We retrospectively identified all adults with laboratory-confirmed leptospirosis in Far North Queensland, Australia, between January 1998 and May 2016. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007205DOI Listing
February 2019

Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira.

Sci Rep 2019 Feb 12;9(1):1839. Epub 2019 Feb 12.

Laboratório Especial de Desenvolvimento de Vacinas, Instituto Butantan, Avenida Vital Brasil, 1500, 05503-900, Sao Paulo, SP, Brazil.

Leptospirosis is a worldwide zoonosis caused by pathogenic bacteria of the genus Leptospira, which also includes free-living saprophyte strains. Many aspects of leptospiral basic biology and virulence mechanisms remain unexplored mainly due to the lack of effective genetic tools available for these bacteria. Recently, the type II CRISPR/Cas system from Streptococcus pyogenes has been widely used as an efficient genome engineering tool in bacteria by inducing double-strand breaks (DSBs) in the desired genomic targets caused by an RNA-guided DNA endonuclease called Cas9, and the DSB repair associated machinery. Read More

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http://dx.doi.org/10.1038/s41598-018-37949-xDOI Listing
February 2019

Development and evaluation of latex agglutination test coating with recombinant antigen, LipL32 for serodiagnosis of human leptospirosis.

J Genet Eng Biotechnol 2018 Dec 3;16(2):441-446. Epub 2018 Dec 3.

Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand.

Leptospirosis is a widespread zoonotic disease caused by . Symptoms of disease range from mild symptoms to serious complications including, jaundice, pulmonary hemorrhage, renal and hepatic failure, which may prove fatal. Clinical presentations of this disease are similar with other febrile illness. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353862PMC
December 2018
2 Reads

Estimating the burden of leptospirosis in Sri Lanka; a systematic review.

BMC Infect Dis 2019 Feb 6;19(1):119. Epub 2019 Feb 6.

Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, 50008, Sri Lanka.

Background: Although the assessment of disease burden should be a priority for allocating resources, leptospirosis is grossly underestimated despite its true burden in Sri Lanka. This study aimed to assess the morbidity and mortality of leptospirosis based on routine surveillance data, hospital reported data and scientific publications from Sri Lanka.

Method: A systematic review was carried out, and Pub Med, MEDLINE®, BIOSIS Previews, Zoological Record, Web of Science Core Collection, Current Contents Connect, KCI-Korean Journal Database, BIOSIS Citation Index, Data Citation Index, SciELO Citation Index and Google Scholar databases were searched. Read More

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http://dx.doi.org/10.1186/s12879-018-3655-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364467PMC
February 2019

Inferring pathogen-host interactions between Leptospira interrogans and Homo sapiens using network theory.

Sci Rep 2019 Feb 5;9(1):1434. Epub 2019 Feb 5.

Gujarat Biotechnology Research Centre, Department of Science & Technology, Government of Gujarat, Gandhinagar, 382011, India.

Leptospirosis is the most emerging zoonotic disease of epidemic potential caused by pathogenic species of Leptospira. The bacterium invades the host system and causes the disease by interacting with the host proteins. Analyzing these pathogen-host protein interactions (PHPIs) may provide deeper insight into the disease pathogenesis. Read More

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http://www.nature.com/articles/s41598-018-38329-1
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http://dx.doi.org/10.1038/s41598-018-38329-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363727PMC
February 2019
1 Read

Pharmacokinetics of enrofloxacin HCl-2H O (ENRO-C), PK/PD, and Monte Carlo modeling vs. Leptospira spp. in cows.

J Vet Pharmacol Ther 2019 Feb 3. Epub 2019 Feb 3.

Department of Physiology and Pharmacology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.

The pharmacokinetics, PK/PD ratios, and Monte Carlo modeling of enrofloxacin HCl-2H O (Enro-C) and its reference preparation (Enro-R) were determined in cows. Fifty-four Jersey cows were randomly assigned to six groups receiving a single IM dose of 10, 15, or 20 mg/kg of Enro-C (Enro-C , Enro-C , Enro-C ) or Enro-R. Serial serum samples were collected and enrofloxacin concentrations quantified. Read More

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http://dx.doi.org/10.1111/jvp.12748DOI Listing
February 2019

Identification of a novel protein in the genome sequences of Leptospira interrogans with the ability to interact with host's components.

J Microbiol Immunol Infect 2019 Jan 22. Epub 2019 Jan 22.

Laboratorio Especial de Desenvolvimento de Vacinas-Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, Sao Paulo, SP, Brazil. Electronic address:

Background: Leptospirosis is an infectious disease that affects humans and animals worldwide. The etiological agents of this disease are the pathogenic species of the genus Leptospira. The mechanisms involved in the leptospiral pathogenesis are not full understood. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.012DOI Listing
January 2019
1 Read

Asymptomatic leptospiral infection is associated with canine chronic kidney disease.

Comp Immunol Microbiol Infect Dis 2019 Feb 24;62:64-67. Epub 2018 Nov 24.

Department of Microbiology and Parasitology, Biomedical Institute of the Fluminense Federal University, Brazil. Electronic address:

Canine leptospirosis is characterized by an acute or chronic disease. Some dogs may act as asymptomatic carriers, keeping the agent in the renal tubules and eliminating it in the urine for an extended period. Chronic kidney disease (CKD) is multifactorial and pathophysiology has been widely discussed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01479571183010
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http://dx.doi.org/10.1016/j.cimid.2018.11.009DOI Listing
February 2019
3 Reads

Diagnosis of Murine Typhus by Serology in Peninsular Malaysia: A Case Report Where Rickettsial Illnesses, Leptospirosis and Dengue Co-Circulate.

Trop Med Infect Dis 2019 Jan 31;4(1). Epub 2019 Jan 31.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. Read More

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http://dx.doi.org/10.3390/tropicalmed4010023DOI Listing
January 2019
1 Read

Pathogenic Leptospira species are widely disseminated among small mammals in Atlantic Forest biome.

Transbound Emerg Dis 2019 Jan 31. Epub 2019 Jan 31.

Universidade Federal Fluminense, Laboratório de Bacteriologia Veterinária, Instituto Biomédico, Rua Prof. Hernani Mello, Niterói, Rio de JaneiroBrazil.

Leptospirosis is a common worldwide bacterial zoonosis and has been studied in One Health approaches. Small mammals are described as the most important maintenance reservoirs of several pathogens in nature, including leptospires. The aim of this study was to identify infection by leptospires among small mammals on the Atlantic forest biome and evaluate their potential as carriers of these spirochetes. Read More

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http://dx.doi.org/10.1111/tbed.13135DOI Listing
January 2019

Visual and Rapid Detection of Leptospira interrogans Using Multiple Cross-Displacement Amplification Coupled with Nanoparticle-Based Lateral Flow Biosensor.

Vector Borne Zoonotic Dis 2019 Jan 31. Epub 2019 Jan 31.

2 Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University , Hangzhou, China .

Leptospirosis is a worldwide zoonosis caused by spirochetes from the genus Leptospira. In the present study, a visual and rapid method for detecting Leptospira interrogans was developed based on multiple cross-displacement amplification (MCDA) and nanoparticle-based lateral flow biosensor (LFB). A set of 10 primers was specifically designed to recognize 10 regions of the lipL 41 gene of L. Read More

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http://dx.doi.org/10.1089/vbz.2018.2395DOI Listing
January 2019
1 Read

Leptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay.

Transbound Emerg Dis 2019 Jan 26. Epub 2019 Jan 26.

Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Montevideo, Uruguay.

Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identification of the agent. Here, we report one confirmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5. Read More

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http://dx.doi.org/10.1111/tbed.13133DOI Listing
January 2019
3 Reads

Historical perspective: Leptospirosis outbreaks affecting military forces.

Authors:
Leslie L Clark

MSMR 2019 Jan;26(1):20-22

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January 2019

An outbreak of leptospirosis among reserve military recruits, Hulu Perdik, Malaysia.

Eur J Clin Microbiol Infect Dis 2019 Mar 24;38(3):523-528. Epub 2019 Jan 24.

Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Here, we investigated an outbreak of leptospirosis among reserve military recruits that occurred following a survival exercise in the Hulu Perdik forest within the Hulu Langat district, Kuala Lumpur, Malaysia. Blood samples from the 12 patients that presented symptoms for febrile illness on clinical examination were subjected to laboratory investigation, comprising Lepto IgM rapid test, IgM ELISA, and microscopic agglutination test (MAT). All these patients were interviewed for possible risk factors for leptospirosis. Read More

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http://dx.doi.org/10.1007/s10096-018-03450-6DOI Listing
March 2019
1 Read
2.668 Impact Factor

Discovery of Leptospira spp. seroreactive peptides using ORFeome phage display.

PLoS Negl Trop Dis 2019 Jan 24;13(1):e0007131. Epub 2019 Jan 24.

Institute for Biochemistry, Biotechnology and Bioinformatics, Braunschweig University of Technology, Braunschweig, Germany.

Background: Leptospirosis is the most common zoonotic disease worldwide. The diagnostic performance of a serological test for human leptospirosis is mainly influenced by the antigen used in the test assay. An ideal serological test should cover all serovars of pathogenic leptospires with high sensitivity and specificity and use reagents that are relatively inexpensive to produce and can be used in tropical climates. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007131
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http://dx.doi.org/10.1371/journal.pntd.0007131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363232PMC
January 2019
4 Reads

Environmental risk factors of leptospirosis in urban settings: a systematic review protocol.

BMJ Open 2019 Jan 21;9(1):e023359. Epub 2019 Jan 21.

Center for Communicable Disease Research, Institute for Public Health, Kuala Lumpur, Malaysia.

Introduction: Leptospirosis is the most common zoonotic disease that causes morbidity and mortality worldwide. The disease can cause sporadic epidemics and recent epidemics have become more apparent in urban localities. There is lack of documented evidence on the specific risk factors of leptospirosis infection among the urbanites, thereby impeding initiatives for prevention in urban settings. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02335
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http://dx.doi.org/10.1136/bmjopen-2018-023359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347878PMC
January 2019
3 Reads

Persistent febrile illnesses in Nepal: A systematic review.

Indian J Med Res 2018 Oct;148(4):385-395

Epidemiology and Control of Neglected Tropical Diseases Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background & Objectives: Although febrile illnesses are a frequent cause of consultation and hospitalization in low- and middle-income countries (LMICs), research has mainly focused on acute febrile illnesses (AFIs). In contrast, there are limited data on the causes of persistent febrile illnesses (PFIs) in LMIC. Lack of clarity on the differential diagnosis of PFIs in the rural tropics leads to the absence of diagnostic guidance tools. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_505_18DOI Listing
October 2018
1 Read
1.661 Impact Factor

Junctional Rhythm: A Rare Sign in Leptospirosis.

Indian J Crit Care Med 2018 Dec;22(12):889-891

Department of Radiation Oncology, RIMS, Ranchi, Jharkhand, India.

Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311981PMC
December 2018
2 Reads

Fatal Leptospirosis and Escherichia coli co-infection in a post-partum woman.

Med J Malaysia 2018 Dec;73(6):427-429

Hospital Seri Manjung, Department of Internal Medicine, Manjung, Perak Malaysia.

The occurrence of Leptospirosis and Escherichia coli coinfection in the post-partum period is a novel case. This report illustrated a previously well woman from a suburban area presented with acute neurological deterioration following a two days history of fever during her puerperal period. Early interventions with fluids, broad spectrum antibiotics and intensive supportive care were given. Read More

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December 2018
3 Reads

Circulating Leptospira species identified in cattle of the Brazilian Amazon.

Acta Trop 2019 Mar 11;191:212-216. Epub 2019 Jan 11.

Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

The present study aimed to detect the most prevalent serogroups and circulating Leptospira species in cows from Brazilian Amazon. Samples of blood serum, urine and kidney of 208 animals were collected at a municipal slaughterhouse in the Baixo Tocantins region of Pará State, Northern Brazil. The tests used were microscopic agglutination test (MAT), bacteriological isolation, polymerase chain reaction (PCR) and DNA sequencing. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.011DOI Listing
March 2019
1 Read

Characterization of a novel protein of Leptospira interrogans exhibiting plasminogen, vitronectin and complement binding properties.

Int J Med Microbiol 2019 Jan 6. Epub 2019 Jan 6.

Laboratorio Especial de Desenvolvimento de Vacinas - Centro de Biotecnologia, Instituto Butantan, Sao Paulo, SP, Brazil; Programa de Pós-Graduação Interunidades em Biotecnologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Leptospirosis is a severe zoonosis caused by pathogenic species of the genus Leptospira. This work focuses on a hypothetical protein of unknown function, encoded by the gene LIC13259, and predicted to be a surface protein, widely distributed among pathogenic leptospiral strain. The gene was amplified from L. Read More

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http://dx.doi.org/10.1016/j.ijmm.2018.12.005DOI Listing
January 2019

Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Nagano Central Hospital, Nagano, Japan.

Here, we report a case of a 64-year-old man with severe leptospirosis infected in an area in Japan that is non-endemic to leptospirosis. Initially, findings of high-grade fever, mild generalised arthralgia, rashes on the trunk, mild thrombocytopenia, elevated liver enzymes and renal dysfunction led to the suspicion of rickettsiosis, which was an endemic infectious disease in the area. Subsequently, leptospirosis was also considered after carefully reviewing patient history, which revealed that he may have been exposed to mice urine. Read More

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http://dx.doi.org/10.1136/bcr-2018-226514DOI Listing
January 2019
1 Read

Role of Plasmapheresis and Extracorporeal Membrane Oxygenation in the Treatment of Leptospirosis Complicated with Pulmonary Hemorrhages.

J Trop Med 2018 2;2018:4520185. Epub 2018 Dec 2.

Department of Internal Medicine, Faculty of Medicine, University of Ruhuna, Sri Lanka.

Introduction: Leptospirosis is an emerging infectious disease associated with multiorgan involvement and significant morbidity and mortality. Although pulmonary hemorrhage due to leptospirosis has a high fatality, specific treatment options are limited and their efficacy is not adequately proven. We opted to find out the current evidence on plasmapheresis and extracorporeal membrane oxygenation (ECMO) in pulmonary hemorrhages due to leptospirosis. Read More

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https://www.hindawi.com/journals/jtm/2018/4520185/
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http://dx.doi.org/10.1155/2018/4520185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304550PMC
December 2018
6 Reads

Recombinant BCG strains expressing chimeric proteins derived from Leptospira protect hamsters against leptospirosis.

Vaccine 2019 Feb 7;37(6):776-782. Epub 2019 Jan 7.

Programa de Pós-Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address:

Leptospirosis is a zoonosis that is responsible for one million human cases per year. Fusing multiple immunogenic antigens represents a promising approach to delivering an effective vaccine against leptospirosis. Mycobacterium bovis bacillus Calmette-Guérin (BCG) is a potential vaccine vector due to its adjuvant properties and safety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193000
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http://dx.doi.org/10.1016/j.vaccine.2018.12.050DOI Listing
February 2019
7 Reads

Leptospirosis: An important infectious disease in North American horses.

Equine Vet J 2019 Jan 10. Epub 2019 Jan 10.

Veterinary Diagnostic Laboratory, University of Kentucky, Lexington, Kentucky, USA.

North American horses are commonly exposed to Leptospira organisms. Leptospira Bratislava is the most common infecting serovar but this serovar has not been confirmed to cause clinical disease in North American horses. Leptospira Pomona type kennewicki is responsible for most of the clinical diseases (leptospirosis) in North American horses. Read More

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http://doi.wiley.com/10.1111/evj.13069
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http://dx.doi.org/10.1111/evj.13069DOI Listing
January 2019
3 Reads

Etiologies of Acute Undifferentiated Febrile Illness in Bangkok, Thailand.

Am J Trop Med Hyg 2019 Jan 7. Epub 2019 Jan 7.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Acute undifferentiated febrile illness (AUFI) has been a diagnostic dilemma in the tropics. Without accurate point-of-care tests, information on local pathogens and clinical parameters is essential for presumptive diagnosis. A prospective hospital-based study was conducted at the Bangkok Hospital for Tropical Diseases from 2013 to 2015 to determine common etiologies of AUFI. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0407DOI Listing
January 2019
3 Reads

An outbreak of leptospirosis among kayakers in Brittany, North-West France, 2016.

Euro Surveill 2018 Nov;23(48)

European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden.

In September 2016, a cluster of seven kayakers with clinical symptoms of leptospirosis with onset since July 2016 was reported to French health authorities. Human and animal investigations were undertaken to describe the outbreak, identify the likely place and source of infection and implement necessary control measures. We identified 103 patients with clinical symptoms of leptospirosis between 1 June and 31 October 2016 who lived in the Ille-et-Vilaine district in Brittany. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2018.23.48.1700848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280422PMC
November 2018

Despite high-risk exposures, no evidence of zoonotic transmission during a canine outbreak of leptospirosis.

Zoonoses Public Health 2019 Mar 7;66(2):223-231. Epub 2019 Jan 7.

Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.

Leptospirosis is a bacterial zoonosis that affects many mammals, including humans and dogs; dogs can transmit the bacteria to humans, but the frequency of transmission and highest risk exposures are poorly understood. During 2016-2017, the Maricopa County Department of Public Health, Arizona Department of Health Services and Centers for Disease Control and Prevention investigated the zoonotic potential of a canine leptospirosis outbreak in the Phoenix metro area. We identified symptomatic persons exposed to canine leptospirosis cases by conducting active and passive surveillance. Read More

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http://doi.wiley.com/10.1111/zph.12557
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http://dx.doi.org/10.1111/zph.12557DOI Listing
March 2019
18 Reads

Phagocytosis of Leptospira by leukocytes from mice with different susceptibility to leptospirosis and possible role of chemokines.

BMC Microbiol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Laboratório de Bacteriologia, Instituto Butantan, São Paulo, Brazil.

Background: Leptospirosis is a widespread zoonosis caused by pathogenic prokaryotic microbes of the genus Leptospira. Although there are several reports in the literature, host-pathogen interaction is still poorly understood. The role of chemokine expression is important on the chemotaxis, activation and regulation of immune cells. Read More

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https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12866-018-1371-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323685PMC
January 2019
2 Reads

Comparison of Mycobacterium ulcerans (Buruli ulcer) and Leptospira sp. (Leptospirosis) dynamics in urban and rural settings.

PLoS Negl Trop Dis 2019 01 7;13(1):e0007074. Epub 2019 Jan 7.

Equipe EA 3593, Ecosystèmes amazoniens et pathologie tropicale, Université de la Guyane, Cayenne, Guyane française.

Background: Zoonotic pathogens respond to changes in host range and/or pathogen, vector and host ecology. Environmental changes (biodiversity, habitat changes, variability in climate), even at a local level, lead to variability in environmental pathogen dynamics and can facilitate their transmission from natural reservoirs to new susceptible hosts. Whilst the environmental dynamics of aquatic bacteria are directly linked to seasonal changes of their habitat they also rely on the ecological processes underpining their transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336349PMC
January 2019
2 Reads

Decreasing trend of seroprevalence of leptospirosis at All India Institute of Medical Sciences New Delhi: 2014-2018.

J Family Med Prim Care 2018 Nov-Dec;7(6):1425-1428

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Background: Leptospirosis is an important emerging public health problem in India. There is limited information regarding the seroprevalence of leptospirosis in population from northern states of India. This study reports result of a 4-year-retrospective sero-epidemiological survey of leptospirosis conducted in a teaching tertiary care hospital in New Delhi, India. Read More

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http://www.jfmpc.com/text.asp?2018/7/6/1425/246478
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http://dx.doi.org/10.4103/jfmpc.jfmpc_198_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293953PMC
January 2019
2 Reads

Spontaneous Lens Absorption Initially Misdiagnosed as Crystalline Lens Luxation

Turk J Ophthalmol 2018 Dec;48(6):320-322

Selçuk University Faculty of Medicine, Department of Ophtalmology, Konya, Turkey

Spontaneous lens absorption (SLA) is a rare complication of hypermature cataract. However, this condition has been reported in several cases of hypermature cataracts that were caused by trauma, senility, uveitic disorders such as Fuchs’ uveitis syndrome (FUS), and infectious disorders including leptospirosis and rubella. We report a case of spontaneous absorption of a hypermature cataract secondary to FUS. Read More

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http://dx.doi.org/10.4274/tjo.65725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330671PMC
December 2018
2 Reads

Leptospirosis.

J Med Microbiol 2019 Jan 3. Epub 2019 Jan 3.

1​Respiratory and Vaccine Preventable Bacteria Reference Unit, Public Health England - National Infection Service, London, UK.

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http://dx.doi.org/10.1099/jmm.0.000899DOI Listing
January 2019

Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect.

J Glob Health 2019 Jun;9(1):010302

Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Neston, UK.

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http://dx.doi.org/10.7189/jogh.09.010302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304173PMC
June 2019
1 Read

Human Mozdok leptospirosis first diagnosed by serum agglutinin-absorption tests in the Slovak Republic.

Epidemiol Mikrobiol Imunol 2018 ;67(3):114-120

Introduction: The serovar Mozdok related leptospirosis in humans were not yet feasibly diagnosed using merely the standard micro-agglutination test (MAT) what was perhaps due to the impossibility to distinguish them from illnesses that are caused by Leptospira strains belonging to other serovars of the serogroup Pomona. On the contrary, leptospires of the Mozdok serovar were cultured from rodents and domestic animals world-wide including Central Europe where only Leptospira strains of the serovars Pomona and Mozdok are known to be present till now.

Study Objective: The aim of the study was to discover if leptospires of Mozdok serovar may cause human leptospirosis that remained hidden till now among infections diagnosed merely by MAT as Pomona illnesses. Read More

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January 2018
1 Read

Atypical Renal Presentation in Severe Leptospirosis.

Kidney Int Rep 2019 Jan 29;4(1):168-170. Epub 2018 Aug 29.

Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183019
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http://dx.doi.org/10.1016/j.ekir.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308378PMC
January 2019
6 Reads

Spatial epidemiological approaches to inform leptospirosis surveillance and control: A systematic review and critical appraisal of methods.

Zoonoses Public Health 2019 Mar 28;66(2):185-206. Epub 2018 Dec 28.

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.

Leptospirosis is a global zoonotic disease that the transmission is driven by complex geographical and temporal variation in demographics, animal hosts and socioecological factors. This results in complex challenges for the identification of high-risk areas. Spatial and temporal epidemiological tools could be used to support leptospirosis control programs, but the adequacy of its application has not been evaluated. Read More

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http://dx.doi.org/10.1111/zph.12549DOI Listing
March 2019
2.065 Impact Factor

[Update on leptospirosis].

Rev Med Interne 2018 Dec 24. Epub 2018 Dec 24.

Unité des maladies infectieuses et tropicales, centre hospitalier Andrée-Rosemon, Cayenne, Guyane; Équipe EA 3593, ecosystèmes amazoniens et pathologie tropicale, université de la Guyane, Cayenne, Guyane.

Leptospirosis is a worldwide spirochetal zoonosis whose global incidence is increasing and is probably underestimated. Leptospirosis has long been associated with occupational contact with animals (rats and cattle) and has become in developed countries a pathology more related to recreational activities with exposure to fresh water (canoeing, swimming, canyoning) and to an environment contaminated by urine from leptospires excretory rodents. Leptospirosis should be one of the differential diagnoses to be considered when returning from travel to tropical areas, particularly Southeast Asia, and particularly during the rainy season. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.12.003DOI Listing
December 2018

Erratum to "MAT cross-reactions or vaccine cross-protection: retrospective study of 863 leptospirosis canine cases" [Heliyon 4 (11) (November 2018) e00869].

Heliyon 2018 Dec 17;4(12):e01027. Epub 2018 Dec 17.

Laboratoire de Bactériologie Médicale et Moléculaire des Leptospires, École Nationale Vétérinaire, ONIRIS, Route de Gachet, CS 40706, 44307 Nantes Cedex 03, France.

[This corrects the article DOI: 10.1016/j.heliyon. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e01027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299099PMC
December 2018

Leptospira infection and shedding in cats in Thailand.

Transbound Emerg Dis 2018 Dec 23. Epub 2018 Dec 23.

Clinic of Small Animal Internal Medicine, Centre of Clinical Veterinary Medicine LMU Munich, Munich, Germany.

In Thailand, leptospirosis is considered an emerging disease in humans and animals. Many species can shed pathogenic Leptospira, including domestic cats (felis catus), which might be able to pose a risk to humans. There are no studies on Leptospira infections in cats in Thailand, but in other countries, it was demonstrated that cats can shed pathogenic Leptospira with high prevalences. Read More

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http://doi.wiley.com/10.1111/tbed.13110
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http://dx.doi.org/10.1111/tbed.13110DOI Listing
December 2018
6 Reads

Development of real-time loop-mediated isothermal amplification (RealAmp) method for sensitive and rapid detection of pathogenic and nonpathogenic Leptospira.

Lett Appl Microbiol 2019 Feb;68(2):196-203

Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Leptospirosis is a zoonotic disease that is spread through water contaminated with the spirochete Leptospira. In our study, RealAmp (real-time loop-mediated isothermal amplification) was developed to distinguish between pathogenic and nonpathogenic Leptospira spp. Melt curve analysis of RealAmp showed two distinct melt curves for pathogenic and nonpathogenic Leptospira spp with a Tm value of 90 ± 2 and 88 ± 2°C. Read More

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http://doi.wiley.com/10.1111/lam.13108
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http://dx.doi.org/10.1111/lam.13108DOI Listing
February 2019
1 Read

Leptospirosis complicated with Guillain Barre syndrome, papillitis and thrombotic thrombocytopenic Purpura; a case report.

BMC Infect Dis 2018 Dec 22;18(1):691. Epub 2018 Dec 22.

National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Background: Leptospirosis is a zoonosis commonly prevalent in tropical countries. Clinical course of leptospirosis varies from mild to severe disease. Here we present a case of leptospirosis complicated with Guillain-Barre Syndrome (GBS), papillitis, and Thrombotic Thrombocytopenic Purpura(TTP). Read More

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http://dx.doi.org/10.1186/s12879-018-3616-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303948PMC
December 2018
2 Reads

Hypoxemic Respiratory Failure Secondary to Zika Virus Infection.

P R Health Sci J 2018 Dec;37(Special Issue):S99-S101

VA Caribbean Healthcare System, San Juan, PR.

An 80-year-old man experienced general weakness, myalgias, arthralgias, fever, chills, and diarrhea for one week. He had hypotension and tachycardia. He also had leukocytosis, thrombocytopenia, increased creatinine levels, elevated liver enzymes, elevated creatine phosphokinase (CPK) levels, and metabolic acidosis with hypoxemia, for which he was admitted to the Intensive Care Unit (ICU). Read More

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December 2018
3 Reads

Leptospirosis.

Workplace Health Saf 2018 Dec 21:2165079918818582. Epub 2018 Dec 21.

1 University of Alabama at Birmingham.

Leptospirosis is a leading zoonotic disease for morbidity and mortality in humans globally. Occupational health nurses should teach workers and the public about leptospirosis and the importance of disrupting the infection source through rodent control, animal vaccination, and flood prevention. Read More

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http://dx.doi.org/10.1177/2165079918818582DOI Listing
December 2018

[Level of knowledge on zoonoses in dog and cat owners].

Rev Salud Publica (Bogota) 2018 Mar-Apr;20(2):198-203

DF: MV. Ph. D. Em Medicina Veterinária Universidade Brasil. Fernandópolis, Brasil.

Objectives : To assess knowledge about zoonoses in dog and cat owners.

Materials And Methods : After applying a questionnaire to 100 owners, data was analyzed by calculating simple means and quantifiable percentage.

Results : 77% of the sample owned dogs and 37% cats. Read More

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http://dx.doi.org/10.15446/rsap.V20n2.68155DOI Listing
October 2016
1 Read

First Reported Case of Neuroleptospirosis Complicated With Anton's Syndrome.

Front Neurol 2018 4;9:966. Epub 2018 Dec 4.

Neurology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Leptospirosis is a spirochetal zoonotic disease with a wide clinical spectrum, often underdiagnosed especially when presented as an acute neurological manifestation. We report a case of a 24-year-old man with serologically positive leptospirosis, who presented with altered sensorium, seizures and subsequently developed cortical blindness. His brain MRI revealed bilateral occipital and later parietal lobe cerebritis. Read More

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http://dx.doi.org/10.3389/fneur.2018.00966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288196PMC
December 2018

A 33-year-old man with jaundice, dyspnoea and fever.

Clin Res Hepatol Gastroenterol 2019 Feb 14;43(1):104-107. Epub 2018 Dec 14.

Department of pneumology, Hopital Notre Dame de Grâce de Gosselies, 6041 Charleroi, Belgium.

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http://dx.doi.org/10.1016/j.clinre.2018.11.007DOI Listing
February 2019

[Biological risk in agriculture and construction workplaces: a survey on perception, knowledge and prevention measures.]

G Ital Med Lav Ergon 2018 Dec;40(4):195-202

Cattedra di Igiene, Dipartimento di Medicina e Scienze per la Salute "Vincenzo Tiberio", Università degli Studi del Molise.

Objectives: Despite the potential presence in many workplaces, biological risk is little known and largely underestimated, except in healthcare environments. Objectives: To evaluate perception, knowledge and behaviors adopted for protection and prevention of biological risk, related also to the occupational activity, among construction and agricultural workers.

Methods: Workers were recruited at farms and construction companies of Molise Region, Central Italy, which were visited within the surveillance activities planned by local institutions. Read More

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December 2018

The monocytosis during human leptospirosis is associated with modest immune cell activation states.

Med Microbiol Immunol 2018 Dec 12. Epub 2018 Dec 12.

Université de La Réunion, CNRS 9192, INSERM U1187, IRD 249, UMR PIMIT, CHU de La Réunion, Unité Mixte Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion, France.

Leptospirosis is a life-threatening zoonotic disease and it has been hypothesized that the innate immune system fails to control the infection through ill-characterized mechanisms. The aim of this observational study was to better evaluate the activation processes of monocytes at the early stage of the disease. Blood samples were taken from healthy donors (n = 37) and patients hospitalized for either non-severe (n = 25) or severe (n = 32) leptospirosis. Read More

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http://dx.doi.org/10.1007/s00430-018-0575-9DOI Listing
December 2018