1,242 results match your criteria Leptomeningeal Carcinomatosis


Outcome and prognostic factors following palliative craniospinal irradiation for leptomeningeal carcinomatosis.

Cancer Manag Res 2019 17;11:789-801. Epub 2019 Jan 17.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg 69120, Germany,

Background: Leptomeningeal carcinomatosis (LC) is a severe complication of metastatic tumor spread to the central nervous system. Prognosis is dismal with a median overall survival (OS) of ~10-15 weeks. Treatment options include radiotherapy (RT) to involved sites, systemic chemo- or targeted therapy, intrathecal chemotherapy and best supportive care with dexamethasone. Read More

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http://dx.doi.org/10.2147/CMAR.S182154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340499PMC
January 2019
1 Read

Anorectal Cancer with Bone Marrow and Leptomeningeal Metastases.

Case Rep Oncol Med 2018 30;2018:9246139. Epub 2018 Dec 30.

Faculty of Medicine, Port Said University, Egypt.

This is an interesting case of anorectal signet ring carcinoma with first presentation of an early stage disease, showing the aggressive disease and the undetectable behavior of this type of histology which can mislead diagnosis. Brain/CNS metastasis from colorectal cancer (CRC) is rare occurring in 3% of cases, and leptomeningeal carcinomatosis (LMC) is extremely rare in CRC (<0.02%). Read More

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https://www.hindawi.com/journals/crionm/2018/9246139/
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http://dx.doi.org/10.1155/2018/9246139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332972PMC
December 2018
4 Reads

[A Case of Cancerous Meningitis in Juvenile Onset Gastric Cancer].

Gan To Kagaku Ryoho 2018 Dec;45(13):1958-1960

Division of General Surgery and Pediatric Surgery, Kyoto Chubu Medical Center.

A 30-year-old woman was diagnosed with advanced gastric cancer(MUL, Circ, Type 4, por1+2, T4a, N3a, M1[LYM, P1, CY1, H0], Stage Ⅳ)on delivery. Because of unresectable, she underwent chemotherapy(first-line: S-1 plus CDDP, secondline: PTX plus Rmab, and third-line: Nmab); approximately 10 months later, she started complaining of headache. We performed a close examination, because she also developed resistance to chemotherapy. Read More

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December 2018
1 Read

Palliative Radiotherapy for Leptomeningeal Carcinomatosis-Analysis of Outcome, Prognostic Factors, and Symptom Response.

Front Oncol 2018 8;8:641. Epub 2019 Jan 8.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.

The purpose of this article is to report our institution's 10-year experience on palliative radiotherapy for the treatment of leptomeningeal carcinomatosis (LC), assessing survival, neurologic outcome, and prognostic factors. We retrospectively analyzed 110 patients who received palliative radiotherapy for LC between 2008 and 2018. The most common histologies were breast cancer ( = 43, 39. Read More

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http://dx.doi.org/10.3389/fonc.2018.00641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331444PMC
January 2019
1 Read

Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease-a case report and literature review.

Acta Neurochir (Wien) 2019 Feb 17;161(2):343-349. Epub 2019 Jan 17.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Hemangioblastomas (HB) are benign tumors of the central nervous system (CNS) that can appear sporadic or as part of von Hippel-Lindau (VHL) disease. It is often curable with surgical resection, but upon relapse, the disease exhibits a treatment-refractory course.

Case Report: A patient treated for sporadic cerebellar HB relapsed 12 years post-surgery. Read More

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http://dx.doi.org/10.1007/s00701-019-03800-zDOI Listing
February 2019
3 Reads

Continued endocrine therapy is associated with improved survival in patients with breast cancer brain metastases.

Clin Cancer Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Medicine, Medical University of Vienna

Background: Brain metastases (BM) are a rare but devastating condition in estrogen receptor (ER)- positive metastatic breast cancer (MBC). While endocrine therapy (ET) is the mainstay of treatment in this disease subtype, only case reports have been published concerning the activity of ET in BM henceforth. Therefore, we aimed to systematically investigate the impact of ET after diagnosis of BM on outcome and clinical course of disease in patients with ERpositive MBC. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1968DOI Listing
January 2019
3 Reads

Palliative cerebrospinal fluid shunting for leptomeningeal metastasis-related hydrocephalus in patients with lung adenocarcinoma: A single-center retrospective study.

PLoS One 2019 10;14(1):e0210074. Epub 2019 Jan 10.

Division of Radiation Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Purpose: Management of leptomeningeal metastasis-related hydrocephalus (LM-H) is particularly challenging regarding the control of severe headache, nausea, and vomiting due to intracranial hypertension. To investigate the improvements of performance status and outcome with cerebrospinal fluid (CSF) shunt surgery for LM-H in patients with lung adenocarcinoma.

Methods: Data on patients with leptomeningeal metastasis-related hydrocephalus from lung adenocarcinoma diagnosed by MR imaging and/or cytological examination were retrospectively analyzed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210074PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328154PMC
January 2019
1 Read

Four lines of anaplastic lymphoma kinase inhibitors and brain radiotherapy in a long-surviving non-small-cell lung cancer anaplastic lymphoma kinase-positive patient with leptomeningeal carcinomatosis.

Anticancer Drugs 2019 Feb;30(2):201-204

Department of Medical Oncology, Sant'Andrea Hospital of Rome.

Lung cancer is the most common tumor and the leading cause of cancer-related death worldwide. Approximately 6.7% of non-small-cell lung cancers (NSCLCs) show anaplastic lymphoma kinase (ALK) rearrangement and could benefit from ALK-targeted treatment. Read More

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http://Insights.ovid.com/crossref?an=00001813-201902000-0001
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http://dx.doi.org/10.1097/CAD.0000000000000699DOI Listing
February 2019
5 Reads

Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer.

Case Rep Oncol 2018 Sep-Dec;11(3):777-783. Epub 2018 Nov 29.

Department of Oncology, Pharmaceutical Care and Sciences, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug. Isolated central nervous system failure without progression at extracranial sites is a common progression pattern in ALK rearrangement-positive NSCLC patients treated with crizotinib. Here, we report the success of crizotinib combined with whole-brain radiotherapy in an ALK rearrangement-positive NSCLC patient who developed leptomeningeal carcinomatosis and progression of multiple brain metastases. Read More

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https://www.karger.com/Article/FullText/492150
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http://dx.doi.org/10.1159/000492150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323405PMC
November 2018
6 Reads

Treatment and survival outcomes of primary intracranial squamous cell carcinoma.

World Neurosurg 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Rep. of Korea.

Background: Primary intracranial squamous cell carcinoma (SCC) is a rare neoplasm associated with malignant transformation of benign epidermoid or dermoid cysts. The optimal treatment and prognosis of this rare disease are unclear.

Methods: A comprehensive literature review identified all reports relevant to clinical presentation, treatment, and outcome of primary intracranial SCC. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.252DOI Listing
December 2018
2 Reads
2.417 Impact Factor

Meningeal carcinomatosis presenting with leukoencephalopathy-like imaging findings.

eNeurologicalSci 2019 Mar 19;14:21-23. Epub 2018 Nov 19.

Department of Neurology, University of Tsukuba, 1-1-1 Tenodai, Tsukuba-city, Japan.

Meningeal carcinomatosis is a unique and rare form of metastasis observed in patients with malignant tumours. Diagnosis is simple when the primary lesion of the malignant tumour is clear, and when multiple miliary lesions are confirmed via cranial contrast MRI; however, many patients exhibit atypical imaging findings. In the present report, we discuss the case of a 72-year-old man who presented with subacute consciousness impairment and MRI findings suggestive of progressive, bilateral leukoencephalopathy-like lesions around the ventricles. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275227PMC
March 2019
1 Read

The Comparative Treatment of Intraventricular Chemotherapy by Ommaya Reservoir vs. Lumbar Puncture in Patients With Leptomeningeal Carcinomatosis.

Front Oncol 2018 20;8:509. Epub 2018 Nov 20.

Emergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.

Leptomeningeal Carcinomatosis (LCM) represents a state of systemic malignant disease with poor prognosis. The purpose of this study is to compare overall survival (OS) between intraventricular chemotherapy through Ommaya reservoir (OR) and chemotherapy through lumbar puncture (LP) in LCM. Forty adult patients with LCM were included. Read More

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http://dx.doi.org/10.3389/fonc.2018.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256195PMC
November 2018
1 Read

Sudden blindness and deafness disclosing meningeal carcinomatosis in non-small cell lung cancer.

Acta Neurol Belg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurology, Rouen University Hospital, 1, rue de Germont, 76031, Rouen Cedex, France.

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http://dx.doi.org/10.1007/s13760-018-01059-2DOI Listing
December 2018

18F-Choline PET/CT in Leptomeningeal Breast Cancer Metastases.

Clin Nucl Med 2019 Feb;44(2):e96-e97

From the Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights that F-choline PET would be used for the identification of leptomeningeal involvement in patients affected by breast cancer, as a support of MRI images. Read More

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http://Insights.ovid.com/crossref?an=00003072-201902000-0003
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http://dx.doi.org/10.1097/RLU.0000000000002407DOI Listing
February 2019
7 Reads

Role of Temozolomide in the Treatment of Cancers Involving the Central Nervous System.

Oncology (Williston Park) 2018 11;32(11):555-60, 569

Temozolomide has been available to oncologists for over 30 years. During this time, it has become an integral part of standard therapy in patients with high-grade gliomas. Given its ability to traverse the blood-brain barrier, temozolomide has also been evaluated in other cancers that involve the central nervous system (CNS). Read More

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November 2018
10 Reads

Symmetric Ventral Brainstem Lesion in Leptomeningeal Carcinomatosis.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Departments of Radiology, National Hospital Organization Higashi-ohmi General Medical Center, Japan.

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http://dx.doi.org/10.2169/internalmedicine.1469-18DOI Listing
November 2018

Leptomeningeal carcinomatosis as primary presentation of metastatic urothelial cancer.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA.

Leptomeningeal spread of carcinoma, referred to here as leptomeningeal carcinomatosis, is an uncommon complication of many cancer types. Its manifestations as the presenting symptoms of a new cancer diagnosis is even less common. This case describes the manifestations of leptomeningeal spread of urothelial carcinoma with review of pathophysiology driving the presenting symptoms of hypertension and headache. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22415
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http://dx.doi.org/10.1136/bcr-2017-224150DOI Listing
November 2018
5 Reads

Sellar Atypical Teratoid/Rhabdoid Tumor Presenting with Subarachnoid and Intraventricular Hemorrhage.

World Neurosurg 2018 Nov 4. Epub 2018 Nov 4.

Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.

Background: Atypical teratoid/rhabdoid tumors (ATRT) are uncommon malignancies of the central nervous system and are often difficult to distinguish radiographically and pathologically from other common tumors. We present the first case of sellar ATRT presenting with subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH).

Case Description: A 62-year-old woman, who had presented with symptoms of headache, diabetes insipidus, hypothyroidism, and seizures, was found to have a sellar tumor with hemorrhagic transformation. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.198DOI Listing
November 2018
7 Reads

Application of 3D T1 Black-Blood Imaging in the Diagnosis of Leptomeningeal Carcinomatosis: Potential Pitfall of Slow-Flowing Blood.

Authors:
S A Nabavizadeh

AJNR Am J Neuroradiol 2018 Dec 1;39(12):E125. Epub 2018 Nov 1.

Department of Neuroradiology Hospital of the University of Pennsylvania Philadelphia, Pennsylvania.

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http://dx.doi.org/10.3174/ajnr.A5832DOI Listing
December 2018

A Retrospective Analysis of the Clinical Outcomes of Leptomeningeal Metastasis in Patients with Solid Tumors.

Brain Tumor Res Treat 2018 Oct;6(2):54-59

Department of Internal Medicine, Kosin University Gaspel Hospital, Busan, Korea.

Background: Leptomeningeal metastasis (LM) is an uncommon, but devastating complication of advanced cancer and has no standard treatment. Herein, we analyzed the clinical characteristics and outcomes of patients with solid tumors who were diagnosed with LM.

Methods: Between January 2007 and December 2017, we retrospectively analyzed the medical records of patients with solid tumors who were diagnosed with LM. Read More

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http://dx.doi.org/10.14791/btrt.2018.6.e12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212684PMC
October 2018
2 Reads

Successful Treatment with Osimertinib and Chemotherapy in a Non-Small Cell Lung Cancer Patient with EGFR Mutation and Meningeal Carcinomatosis.

J Thorac Oncol 2018 Nov;13(11):e219-e220

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183063
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http://dx.doi.org/10.1016/j.jtho.2018.05.023DOI Listing
November 2018
16 Reads

Diagnostic Approach to Chronic Meningitis.

Neurol Clin 2018 Nov 20;36(4):831-849. Epub 2018 Sep 20.

Department of Neurology, Geisinger Commonwealth School of Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, USA.

Chronic meningitis is defined as cerebrospinal fluid pleocytosis that persists for at least 4 weeks without spontaneous resolution. The differential diagnosis of chronic meningitis is broad, encompassing 4 main categories, including infectious, autoimmune, neoplastic, and idiopathic. Up to one-third of cases have no discernible cause, making chronic meningitis a diagnostic dilemma for many clinicians. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183123
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http://dx.doi.org/10.1016/j.ncl.2018.06.004DOI Listing
November 2018
16 Reads

Treatment Results and Prognostic Factors of Brain Metastases From Ovarian Cancer: A Single Institutional Experience of 56 Patients.

Int J Gynecol Cancer 2018 Oct;28(8):1631-1638

Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.

Objectives: The most appropriate treatments for brain metastases from ovarian cancer have not been established mainly because of its rarity. The objective of this study was to describe clinical results of treatment and prognostic factors of patients with brain metastases from ovarian cancer treated at a single institution.

Materials And Methods: We retrieved information from the electronic medical records of 56 consecutive patients (2. Read More

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http://dx.doi.org/10.1097/IGC.0000000000001341DOI Listing
October 2018
4 Reads

Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis.

Eur Neurol 2018 19;80(1-2):68-70. Epub 2018 Sep 19.

Department of Pathomorphology and Oncologic Cytology, Wroclaw Medical University, Wroclaw, Poland.

We present a rare case of primary malignant melanoma of the central nervous system. We underline the difficulties we faced during diagnostic procedures. Finally, postmortem examination revealed the diagnosis of primary pauci--melanotic leptomeningeal melanomatosis. Read More

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http://dx.doi.org/10.1159/000493197DOI Listing
January 2019
7 Reads

Treatment outcomes of radiotherapy for primary spinal cord glioma.

Strahlenther Onkol 2019 Feb 10;195(2):164-174. Epub 2018 Sep 10.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic of).

Purpose: Spinal cord gliomas are rare, and there is no consensus on the optimal radiotherapy (RT) regimen. Herein, we investigated therapeutic outcomes in spinal cord gliomas to obtain clues for the optimal RT regimen.

Methods: We assessed 45 patients who received RT for primary spinal cord non-ependymoma gliomas between 2005 and 2017: 37 (82%) received postoperative RT, 6 (13%) underwent definitive RT without surgery, and 2 (5%) received salvage RT for recurrent tumors. Read More

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http://dx.doi.org/10.1007/s00066-018-1366-3DOI Listing
February 2019
12 Reads

A Novel Implantable Cerebrospinal Fluid Reservoir : A Pilot Study.

J Korean Neurosurg Soc 2018 Sep 31;61(5):640-644. Epub 2018 Aug 31.

Neuro-Oncology Clinic, Center for Specific Organs Center, National Cancer Center, Goyang, Korea.

Objective: The purpose of this pilot study was to examine the safety and function of the newly developed cerebrospinal fluid (CSF) reservoir called the V-Port.

Methods: The newly developed V-Port consists of a non-collapsible reservoir outlined with a titanium cage and a connector for the ventricular catheter to be assembled. It is designed to be better palpated and more durable to multiple punctures than the Ommaya reservoir. Read More

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http://dx.doi.org/10.3340/jkns.2018.0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129757PMC
September 2018
1 Read

Cauda equine syndrome as the primary symptom of leptomeningeal metastases from lung cancer: a case report and review of literature.

Onco Targets Ther 2018 20;11:5009-5013. Epub 2018 Aug 20.

Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China,

Cauda equine syndrome (CES) is a neurological condition caused by compression of the cauda equine. Here, we demonstrate a case of CES as the primary symptom of leptomeningeal metastases from non-small cell lung carcinoma without brain metastases. A 59-year-old male suffered progressive lower extremity motor dysfunction, urinary dysfunction, and lower extremity sensory dysfunction. Read More

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http://dx.doi.org/10.2147/OTT.S165299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109657PMC
August 2018
3 Reads

UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts.

J Neurooncol 2018 Nov 21;140(2):209-224. Epub 2018 Aug 21.

Division of Pediatric Surgery, Department of Surgery, University of Alabama, Birmingham, Birmingham, AL, USA.

Background: Group 3 tumors account for approximately 25-30% of medulloblastomas and have the worst prognosis. UAB30 is a novel synthetic rexinoid shown to have limited toxicities in humans and significant efficacy in the pediatric neuroectodermal tumor, neuroblastoma. We hypothesized that treatment with UAB30 would decrease tumorigenicity in medulloblastoma patient-derived xenografts (PDXs). Read More

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http://link.springer.com/10.1007/s11060-018-2950-1
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http://dx.doi.org/10.1007/s11060-018-2950-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239946PMC
November 2018
14 Reads

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis.

BMC Cancer 2018 Aug 16;18(1):825. Epub 2018 Aug 16.

Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.

Background: Pneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.

Case Presentation: A 71-year-old woman with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma was admitted to our hospital because of reduced consciousness. She was diagnosed as having leptomeningeal carcinomatosis (LM) using lumbar puncture. Read More

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http://dx.doi.org/10.1186/s12885-018-4743-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097412PMC
August 2018
9 Reads

[A case of leptomeningeal carcinomatosis involving loss of eyesight after total gastrectomy for gastric cancer].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(8):755-759

Department of Surgery, Tsu Seikyo Hospital.

A 78-year-old woman had undergone total gastrectomy and chemotherapy for gastric cancer (pT4N3bM0 Stage IIIC, poorly differentiated adenocarcinoma). She received S-1 monotherapy 3 times weekly (S-1 at 80mg twice daily for 14 days, every 3 weeks). She underwent routine examinations, including tumor markers and computed tomography. Read More

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https://www.jstage.jst.go.jp/article/nisshoshi/115/8/115_755
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http://dx.doi.org/10.11405/nisshoshi.115.755DOI Listing
January 2018
21 Reads

Intracranial Response to Anti-Programmed Death 1 Therapy in a Patient with Metastatic Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis.

Oncologist 2018 Dec 2;23(12):e159-e161. Epub 2018 Aug 2.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Central nervous system metastasis in non-small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combined with stereotactic radiosurgery. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0022DOI Listing
December 2018
12 Reads

Management of breast cancer brain metastases.

Chin Clin Oncol 2018 Jun;7(3):30

Section of Neurosurgery, Niigata Cancer Center Hospital, Niigata, Japan.

Brain metastases are usual in breast cancer with poor prognosis and few available therapeutic options. The efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) against brain metastases from EGFR mutation-positive non-small cell lung cancer (NSCLC) showed promising antitumor activity, on the other hand, the main treatment of breast cancer brain metastases (BCBMs) is only local therapy such as surgery or radiotherapy. The goal of treatment includes stabilizing or improving neurological function and palliating neurological symptom. Read More

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http://dx.doi.org/10.21037/cco.2018.05.06DOI Listing
June 2018
15 Reads

[Two Cases of Bilateral Orbital Metastases of Breast Cancer].

No Shinkei Geka 2018 07;46(7):615-621

Department of Neurosurgery, Shinsuma General Hospital.

Two cases of breast cancer with bilateral orbital metastases associated with intracranial metastases are presented. Case 1:A 61-year-old woman who was diagnosed with breast cancer 14 years earlier presented with rapid deterioration of visual acuity, eye pain, and limitation of left-sided extraocular motility. Magnetic resonance(MR)images showed an enhanced lesion in the left orbital apex, ethmoid sinus, and right middle fossa. Read More

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http://dx.doi.org/10.11477/mf.1436203779DOI Listing
July 2018
5 Reads

Malignant transformation of epidermoid cyst with diffuse leptomeningeal carcinomatosis on skull base and trigeminal perineural spread.

J Neuroradiol 2018 Sep 20;45(5):337-340. Epub 2018 Jul 20.

AP-HP, hospital Pitié-Salpêtrière, neuroradiology department, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.neurad.2018.07.002DOI Listing
September 2018
15 Reads

Application of 3D Fast Spin-Echo T1 Black-Blood Imaging in the Diagnosis and Prognostic Prediction of Patients with Leptomeningeal Carcinomatosis.

AJNR Am J Neuroradiol 2018 Aug 12;39(8):1453-1459. Epub 2018 Jul 12.

From the Department of Radiology (J.O., S.H.C., E.L., D.J.S., S.W.J., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea.

Background And Purpose: Contrast-enhanced 3D fast spin-echo T1 black-blood imaging selectively suppresses the signal of blood flow and could provide a higher contrast-to-noise ratio compared with contrast-enhanced 3D ultrafast gradient recalled echo (contrast-enhanced gradient recalled echo) and 2D spin-echo T1WI (contrast-enhanced spin-echo). The purpose of our study was to evaluate whether black-blood imaging can improve the diagnostic accuracy for leptomeningeal carcinomatosis compared with contrast-enhanced gradient recalled-echo and contrast-enhanced spin-echo and, furthermore, to determine whether the grade of leptomeningeal carcinomatosis evaluated on black-blood imaging is a significant predictor of progression-free survival.

Materials And Methods: Leptomeningeal carcinomatosis ( = 78) and healthy ( = 31) groups were enrolled. Read More

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http://dx.doi.org/10.3174/ajnr.A5721DOI Listing
August 2018
4 Reads

Clinical manifestations and location of brain metastases as prognostic markers.

Curr Probl Cancer 2018 Jun 12. Epub 2018 Jun 12.

Instituto Nacional de Cancerología, Mexico City, Mexico.

Background: Brain metastases (BM) are a frequent complication of cancer and are regularly seen in clinical practice. New treatment modalities are improving survival after diagnosis of BM. However, symptoms are rarely reported and their significance is not well established. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2018.06.002DOI Listing
June 2018
16 Reads

Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus: Report of a very unusual combination.

Radiol Case Rep 2018 Jun 7;13(3):555-558. Epub 2018 Mar 7.

The University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA.

Dysembryoplastic neuroepithelial tumors (DNETs) are typically benign World Health Organization (WHO) grade I tumors of the cortical or deep gray matter with a favorable prognosis. We encountered a patient with DNET who has been evaluated and treated for West Nile encephalitis 7 months before presentation. Over the course of 2 years, the patient developed diffuse leptomeningeal carcinomatosis. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030550PMC
June 2018
17 Reads

Posterior Fossa Metastasis-Associated Obstructive Hydrocephalus in Adult Patients: Literature Review and Practical Considerations from the Neuro-Oncology Club of the French Society of Neurosurgery.

World Neurosurg 2018 Sep 20;117:271-279. Epub 2018 Jun 20.

Department of Neurosurgery, Sainte-Anne Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France; Inserm, U894, IMA-Brain, Centre de Psychiatrie et Neurosciences, Paris, France. Electronic address:

Background: There is no consensus concerning the management of adult patients with posterior fossa metastasis-associated obstructive hydrocephalus, especially regarding surgical procedures. A literature review was performed to assess the surgical strategy in the management of patients with metastatic brain tumor.

Methods: A literature search was conducted of PubMed in November 2017 to identify all studies concerning brain metastases and obstructive hydrocephalus in English. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.084DOI Listing
September 2018
3 Reads

An unusual case of leptomeningeal carcinomatosis in a patient with primary adenocarcinoma of the lung.

BMJ Case Rep 2018 Jun 21;2018. Epub 2018 Jun 21.

Department of Respiratory, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

A 72-year-old man was brought to the emergency department with acute onset confusion and haemoptysis. Chest X-ray showed a possible lung mass, while CT head showed a fluid-filled, space-occupying lesion (SOL) in the right frontal lobe of the brain. MRI head indicated that this SOL had spilt its contents into the subarachnoid and intraventricular spaces. Read More

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http://dx.doi.org/10.1136/bcr-2017-223649DOI Listing
June 2018
8 Reads

One-year prognosis of non-traumatic cortical subarachnoid haemorrhage: A prospective series of 34 patients.

Neurologia 2018 Jun 11. Epub 2018 Jun 11.

Servicio de Neurología, Hospital La Fe, Valencia, España.

Introduction: Cortical subarachnoid haemorrhage (cSAH) has multiple aetiologies. No prospective study has reported the long-term progression of the condition. The objective of this study is to describe the clinical and aetiological characteristics of patients with cSAH and to gain insight into prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02134853183002
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http://dx.doi.org/10.1016/j.nrl.2017.12.008DOI Listing
June 2018
25 Reads

Ceritinib Treatment for Carcinomatous Meningitis with a Secondary Mutation at I1171T in Anaplastic Lymphoma Kinase.

Intern Med 2018 Nov 6;57(21):3153-3155. Epub 2018 Jun 6.

Division of Respiratory Medicine, Chiba Cancer Center, Japan.

The mechanisms underlying anaplastic lymphoma kinase (ALK) resistance have not been well investigated in clinical practice. We herein report the case of a lung cancer patient with carcinomatous meningitis who had an ALK I1171T resistance mutation revealed by direct DNA sequencing of the cerebrospinal fluid after treatment with cytotoxic chemotherapy, crizotinib, and alectinib. I1171T is considered to be sensitive to ceritinib. Read More

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http://dx.doi.org/10.2169/internalmedicine.0397-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262718PMC
November 2018
1 Read

Fulminant leptomeningeal carcinomatosis from a malignant melanoma arising in a cerebellopontine epidermoid cyst: A rare case with diagnostic pointers.

Neuropathology 2018 Oct 6;38(5):503-509. Epub 2018 Jun 6.

Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

A malignant component in an epidermoid cyst is rare. We report an exceptionally rare case of a malignant melanoma arising in an epidermoid cyst located in the cerebellopontine (CP) angle. A 26-year-old woman presented with headache, vomiting, ataxia and difficulty in swallowing over the previous 3 months. Read More

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http://dx.doi.org/10.1111/neup.12480DOI Listing
October 2018
10 Reads
1.800 Impact Factor

Treatment of Leptomeningeal Carcinomatosis in a Patient with Metastatic Pancreatic Cancer: A Case Report and Review of the Literature.

Case Rep Oncol 2018 May-Aug;11(2):281-288. Epub 2018 May 17.

Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Pancreatic cancer is the fourth leading cause of cancer-related death with a median survival of 3-11 months when metastatic. We present a patient with metastatic pancreatic cancer and an exceptional response to initial systemic chemotherapy with FOLFIRINOX (fluorouracil, leucovorin, irinotecan, and oxaliplatin). Despite evidence of disease control on body imaging, he developed symptomatic leptomeningeal disease and brain metastases 29 months into treatment. Read More

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http://dx.doi.org/10.1159/000489085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981627PMC
May 2018
19 Reads

[A case of meningeal carcinomatosis mimicking subarachnoid hemorrhage on MRI].

Rinsho Shinkeigaku 2018 Jun 1;58(6):403-406. Epub 2018 Jun 1.

Department of Neurology, Tokyo Medical University.

We report a case of meningeal carcinomatosis that needed to be distinguished from subarachnoid hemorrhage. A 67-year-old female with acute severe headache was admitted to a previous hospital. Since high intensity signal was detected within the parietal cerebral sulci on the right side on brain FLAIR MRI, cerebral angiography was performed due to suspicion of subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001151DOI Listing
June 2018
18 Reads

Embryonal brain tumor with unknown primary lesion and massive cerebrospinal fluid dissemination: A case report.

J Clin Neurosci 2018 Aug 26;54:125-128. Epub 2018 May 26.

Department of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

The 2007 World Health Organization Classification of Tumors of the Central Nervous System (CNS) categorized embryonal tumors of the CNS into three classes: medulloblastoma, CNS primitive neuroectodermal tumor, and atypical teratoid/rhabdoid tumor. Due to the lack of specific histological features, it was sometimes difficult to accurately differentiate CNS embryonal tumors pathologically. Here, we report a case of a young man, who presented with headache. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.04.046DOI Listing
August 2018
33 Reads

Atypical teratoid rhabdoid tumor in a 65-year-old man presenting with disseminated leptomeningeal disease: A case report and review of the literature.

SAGE Open Med Case Rep 2018 14;6:2050313X18775298. Epub 2018 May 14.

Department of Neurology, Duke University Hospital, Durham, NC, USA.

Central nervous system atypical teratoid rhabdoid tumors are very rare aggressive tumor of childhood, primarily occurring at age of less than 3 years old. The prognosis of these tumors is very poor, with a reported median survival of 6-12 months in most cases. Treatment typically consists of aggressive chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.1177/2050313X18775298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954568PMC
May 2018
3 Reads

Tumor-to-Lesion Metastasis: Case Report of Carcinoma Metastasis to Multiple Sclerosis Lesion.

World Neurosurg 2018 Aug 14;116:14-17. Epub 2018 May 14.

Department of Medicine (Neurology), Multiple Sclerosis Centre, University of Alberta, Edmonton, Alberta, Canada.

Background: The term "tumor-to-lesion metastasis" is an extension of "tumor-to-tumor metastasis," which is a rare but well-documented phenomenon. Tumor metastasis to the meninges and/or central nervous system (CNS) is rare in patents with multiple sclerosis (MS), although MS lesions bear many similarities to the primary tumor microenvironment and metastatic niche. We present the first case of malignant tumor metastasis to MS lesions with immunophenotyping of inflammatory cells in the metastatic foci. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183098
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http://dx.doi.org/10.1016/j.wneu.2018.05.031DOI Listing
August 2018
11 Reads

Clinical outcome and prognostic analysis of meningeal carcinomatosis treated by intrathecal chemotherapy.

Expert Rev Pharmacoecon Outcomes Res 2018 Aug 10;18(4):455-460. Epub 2018 May 10.

c Department of Neurology , The Second Hospital of Hebei Medical University , Shijizhuang , China.

Objective: To evaluate the clinical efficacy of meningeal carcinomatosis (MC) treated by intrathecal chemotherapy (IC) and analyzes the prognostic factors.

Methods: The clinical and follow-up data of 33 MC patients was collected and retrospectively analyzed. Potential prognostic factors such as age, gender, primary cancer, transfer time, presence of brain metastasis, intracranial pressure, protein, glucose, vascular endothelial growth factor (VEGF), eastern cooperative oncology group (ECOG) performance status (PS), systemic treatment and IC were discussed. Read More

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http://dx.doi.org/10.1080/14737167.2018.1467269DOI Listing
August 2018
3 Reads

Meningeal carcinomatosis: three case-reports.

World J Surg Oncol 2018 Apr 13;16(1):78. Epub 2018 Apr 13.

Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.

Background: Meningeal carcinomatosis (MC) is characterized by diffuse infiltration of tumor cells in meninges. There is no tumor mass in the brain and parenchyma of the spinal cord. MC is divided into primary and metastatic types. Read More

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http://dx.doi.org/10.1186/s12957-018-1376-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899345PMC
April 2018
8 Reads