27,165 results match your criteria Leprosy Review [Journal]


Genus Psoralea A review of the traditional and modern uses, phytochemistry and pharmacology.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

CSIR-National Botanical Research Institute, Plant Transgenic Laboratory, P.O. Box 436, Rana Pratap Marg,Lucknow-226 001, U.P., India. Electronic address:

Ethnopharmacological Relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. Read More

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December 2018
8 Reads

The inflammasome in leprosy skin lesions: an immunohistochemical evaluation.

Infect Drug Resist 2018 12;11:2231-2240. Epub 2018 Nov 12.

Center of Biological and Health Science, State University of Para, Belem, Brazil,

Objective: Leprosy is a chronic infectious disease presenting with a spectrum of clinical manifestations that correspond to the type of immune response that develops in the host. Factors that may be involved in this process include inflammasomes, cytosolic proteins responsible for the activation of caspase 1, IL-1β and IL-18 secretion, and induction of a type of death called pyroptosis.

Patients And Methods: We evaluated the expression of inflammasome markers (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1 [NLRP1], nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 [NLRP3], caspase 1, IL-1β, and IL-18) by immunohistochemistry in 43 samples of skin lesions of leprosy patients from the groups indeterminate (I) leprosy (13 patients), tuberculoid (TT) leprosy (15 patients), and lepromatous leprosy (LL; 15 patients). Read More

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November 2018

Image Gallery: Multiple cutaneous and oral nodules in histoid leprosy.

Br J Dermatol 2018 Dec;179(6):e227

Department of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

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December 2018

Periorbital Ecchymosis Secondary to Severe Coughing- A Valsalva Associated Phenomenon.

Indian Dermatol Online J 2018 Nov-Dec;9(6):461-462

Department of Dermatology, Venereology and Leprosy, Pandit Bhagwat Dayal Sharma Post graduate Institute of Medical Sciences, Rohtak, Haryana, India.

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December 2018

A Case of Multifocal Tuberculosis Involving Skin and Bone: An Uncommon Presentation.

Indian Dermatol Online J 2018 Nov-Dec;9(6):458-460

Department of Dermatology, Venereology and Leprosy, K S Hegde Medical Academy, affiliated to NITTE (Deemed to be University), Mangalore, Karnataka, India.

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December 2018

Prospective Study of Pulse Therapy in Childhood Pemphigus Disorders.

Indian Dermatol Online J 2018 Nov-Dec;9(6):422-425

Department of Dermatology, Venereology, and Leprosy, Gandhi Medical College, Hyderabad, Telangana, India.

Background: Pemphigus disorders are a group of immunobullous diseases affecting skin and/or mucus membranes. Dexamethasone cyclophosphamide pulse (DCP)/dexamethasone only pulse (DOP) therapy has shown promising results in the management of pemphigus group of diseases in adults.

Aim: To evaluate the outcome of pulse therapy (PT) in pediatric cases diagnosed with pemphigus vulgaris (PV). Read More

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December 2018
2 Reads

A Randomized double Blind Controlled Study Comparing the Efficacy of Intralesional MMR Vaccine with Normal Saline in the Treatment of Cutaneous Warts.

Indian Dermatol Online J 2018 Nov-Dec;9(6):389-393

Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India.

Background: Recently, with better understanding of the immunology of warts, immunotherapeutic approaches have emerged as an effective treatment option for the management of cutaneous warts. Intralesional immunotherapy with MMR vaccine is one such modality but there are still lack of enough placebo-controlled studies.

Aim: To evaluate the efficacy of intralesional MMR in patients of extragenital warts in a double-blinded manner using normal saline as control. Read More

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December 2018

Leprosy cases with respiratory infection - Rule out tuberculosis simultaneously with dapsone syndrome.

Indian J Pharmacol 2018 Jul-Aug;50(4):215-216

Department of Clinical Division, Central Leprosy Teaching and Research Institute, Ministry of Health and Family Welfare, Government of India, Chengalpattu, Tamil Nadu, India.

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December 2018

Etiology of Vaginal/Cervical Discharge Syndrome: Analysis of Data from a Referral Laboratory in Eastern India.

Indian J Dermatol 2018 Nov-Dec;63(6):484-489

Department of VD Serology and Department of STD, Institute of Serology, Kolkata, West Bengal, India.

Context: Sexually transmitted infections (STIs) and reproductive tract infections (RTIs) constitute important public health problem worldwide. Syndromic diagnosis of vaginal/cervical discharge (VCD) is often inaccurate leading to over- or under-treatment.

Aims: This study aimed to ascertain the laboratory-confirmed diagnosis of VCD and their relative frequency in a group of patients presenting to a STI clinic in eastern India and to determine the sensitivity and specificity of clinical diagnosis. Read More

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December 2018

Stigma Associated with Sexually Transmitted Infections among Patients Attending Suraksha Clinic at a Tertiary Care Hospital in Northern India.

Indian J Dermatol 2018 Nov-Dec;63(6):469-474

Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.

Context: Illnesses affecting sexual organs and its correlation with improper sexual behavior lead to a negative attitude and discriminating behavior towards people affected by such disorders.

Aim: The aim was to study the stigma associated with sexually transmitted infections (STIs) among patients attending Suraksha clinic at a tertiary care hospital in northern India.

Settings And Design: This was a hospital-based cross-sectional study. Read More

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December 2018

Clinico-Histological Correlation in Hansen's Disease: Three-year Experience at a Newly Established Tertiary Care Center in Central India.

Indian J Dermatol 2018 Nov-Dec;63(6):465-468

Department of Pathology and Lab Medicine, AIIMS, Bhopal, Madhya Pradesh, India.

Background: Hansen's disease is a chronic infectious disease caused by . It is characterized by a wide range of clinical and histological manifestations. Ridley-Jopling criteria are widely used for classifying leprosy. Read More

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December 2018

Quality of Life of Persons Affected by Leprosy in an Endemic District, West Bengal, India.

Indian J Dermatol 2018 Nov-Dec;63(6):459-464

The Leprosy Mission Trust India, New Delhi, India.

Introduction: Leprosy still remains a public health problem in India. Stigma and associated psychosocial problems are common in leprosy and may affect the quality of life (QoL). This study aimed to assess the QoL of the person affected by leprosy living in Purulia district, West Bengal. Read More

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December 2018

Childhood Leprosy: A Retrospective Descriptive Study from Delhi.

Indian J Dermatol 2018 Nov-Dec;63(6):455-458

Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College, New Delhi, India.

Background: Childhood leprosy is an important marker of the status of the ongoing leprosy control programme, as it is an indicator of active disease transmission in the community. Despite achievement of elimination status of leprosy in 2005, the reported prevalence of childhood cases continue to be high.

Method: A retrospective analysis of 11 year records of leprosy patients aged less than 15 years in a tertiary care hospital of central Delhi was carried out from 2005-2015. Read More

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December 2018

Genomic Reduction at TTC Repeats in the Bacterial Genome of Treated Cases of Hansen's Disease: A Possible Survival Mechanism of .

Indian J Dermatol 2018 Nov-Dec;63(6):449-454

Department of Biochemistry, IPGMER, Kolkata, West Bengal, India.

Introduction: has a small genome and a tendency of persisting as a very low-grade infection. The authors have shown earlier, that the changes in TTC repeats, in genome may contribute to the restriction of the pathogenicity of the bacterium and its survival strategy in case of pure neural Hansen's disease. We suspect, that a similar genomic reduction if happens in treated cases of Hansen's disease, can be a determining factor for developing persisters and relapse. Read More

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December 2018

Author's reply.

Authors:
B B Mahajan

Indian J Dermatol Venereol Leprol 2018 Nov 30. Epub 2018 Nov 30.

Professor, Dermatology, Venereology and Leprosy, Govt. Medical College, Amritsar, Punjab, India.

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November 2018

Factors associated with leprosy in a municipality of the Pre-Amazon region, state of Maranhão, Brazil.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):789-794

Centro de Referência em Doenças Infecciosas e Parasitárias, Departamento de Patologia, Universidade Federal do Maranhão, São Luís, MA, Brasil.

Introduction: The Integrated Program of Leprosy Control was initiated in the municipality of Buriticupu, Maranhão, Brazil, an area considered hyperendemic for leprosy in 2003. It aims at assessing the clinical and epidemiological characteristics of the disease to reduce the detection rate of new cases until 2015. Here, we present the evolution of the indicators of leprosy within the period from 2003 to 2015. Read More

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February 2018
1 Read

Spatial study of leprosy in Bahia, Brazil, 2001-2012: an approach based on the local empirical Bayesian model.

Epidemiol Serv Saude 2018 Nov 29;27(4):e2017479. Epub 2018 Nov 29.

Universidade Federal de Alagoas, Departamento de Medicina, Arapiraca, AL, Brasil.

Objective: to compare the temporal evolution and spatial distribution of epidemiological indicators of leprosy, both crude and also corrected using the empirical Bayesian model, Bahia, Brazil, 2001-2012.

Methods: this was an ecological study using data from the Notifiable Diseases Information System; all 417 municipalities in Bahia were included and the following indicators per 100,000 inhabitants were analyzed - detection rate of new cases in the general population, in those <15 years old, and in those with grade 2 physical disability -; the local empirical Bayesian model was used to smoothen the indicators, and Student's t-test was used to compare means.

Results: indicators estimated by the model were higher than crude indicators; estimated detection rates in the general population and in those <15 years old were higher than crude rates in 253 (60. Read More

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November 2018
1 Read

Second-harmonic generation imaging analysis can help distinguish sarcoidosis from tuberculoid leprosy.

J Biomed Opt 2018 Dec;23(12):1-7

Technology on Photonics Applied to Cell Biology, Campinas, Brazil.

Sarcoidosis and tuberculoid leprosy (TL) are prototypes of granulomatous inflammation in dermatology, which embody one of the histopathology limitations in distinguishing some diseases. Recent advances in the use of nonlinear optical microscopy in skin have enabled techniques, such as second-harmonic generation (SHG), to become powerful tools to study the physical and biochemical properties of skin. We use SHG images to analyze the collagen network, to distinguish differences between sarcoidosis and TL granulomas. Read More

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December 2018
2 Reads

Occult Hepatitis B Virus Infection in Patients with Leprosy.

J Med Virol 2018 Dec 4. Epub 2018 Dec 4.

Sector of Virology, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, Pernambuco, Brazil.

Leprosy patients may present with immune system impairment and have a higher HBV seroprevalence, justifying the investigation of occult HBV infection in these individuals. The aim of this study is to verify the frequency and the clinical factors associated with occult HBV infection in leprosy patients. Between 2015 and 2016, leprosy patients from a Reference Center in Brazil were interviewed to assess clinical data. Read More

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December 2018
3 Reads

HPMA-PLGA Based Nanoparticles for Effective In Vitro Delivery of Rifampicin.

Pharm Res 2018 Dec 3;36(1):19. Epub 2018 Dec 3.

Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, 305817, India.

Purpose: Tuberculosis (TB) chemotherapy witnesses some major challenges such as poor water-solubility and bioavailability of drugs that frequently delay the treatment. In the present study, an attempt to enhance the aqueous solubility of rifampicin (RMP) was made via co-polymeric nanoparticles approach. HPMA (N-2-hydroxypropylmethacrylamide)-PLGA based polymeric nanoparticulate system were prepared and evaluated against Mycobacterium tuberculosis (MTB) for sustained release and bioavailability of RMP to achieve better delivery. Read More

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December 2018
1 Read

LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.

J Immunol 2018 Dec 3. Epub 2018 Dec 3.

Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080.

Both common and rare genetic variants of laccase domain-containing 1 (, previously C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and systemic juvenile idiopathic arthritis. However, the functional relevance of these variants is unclear. In this study, we use LACC1-deficient mice to gain insight into the role of LACC1 in regulating inflammation. Read More

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December 2018
2 Reads

Clinico-microbiological analysis of 121 patients with pulmonary Mycobacteroides abscessus complex disease in Japan - An NTM-JRC study with RIT.

Respir Med 2018 Dec 17;145:14-20. Epub 2018 Oct 17.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

Rationale: No comprehensive analysis has previously been performed to evaluate the clinical aspects of and microbiological evidence associated with Mycobacteroides abscessus complex (MABC) infection in a region, such as Japan, with a low MABC incidence.

Objectives: This study aimed to clarify the clinicopathological characteristics of MABC, which included clinical relatedness to erm(41) sequevar, phenotype (as colony morphology and minimum inhibitory concentration), and genotype.

Methods: A total of 121 MABC patients (68 with M. Read More

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December 2018

Clinical management of leprosy patients during the yellow fever outbreak in Brazil.

Braz J Infect Dis 2018 Nov 27. Epub 2018 Nov 27.

Universidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo, SP, Brazil. Electronic address:

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November 2018

[Leprosy trends following implementation of an intervention project in a state capital in the North of Brazil, 2002-2016].

Cad Saude Publica 2018 Nov 23;34(11):e00007818. Epub 2018 Nov 23.

Instituto Lauro de Souza Lima, Bauru, Brasil.

The project Palmas Free of Leprosy was implemented to improve indicators and deal with the disease, since the capital of Tocantins State is the most hyperendemic state capital in Brazil. This study measures the impact of the project's intervention through trend analysis of the priority indicators in Palmas, from 2002 to 2016. The study was based on an analysis of data from the Brazilian Information System for Notifiable Diseases (SINAN) and reports of applied training courses with problem-solving methodology. Read More

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November 2018

Active search for cases of leprosy in the city of Manaus.

An Bras Dermatol 2018 Nov/Dec;93(6):931-932

Department of Education and Research, Fundação Alfredo da Matta, Manaus (AM), Brazil.

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December 2017

Profile of dermatological consultations in Brazil (2018).

An Bras Dermatol 2018 Nov/Dec;93(6):916-928

Board of directors of the Sociedade Brasileira de Dermatologia, Rio de Janeiro (RJ), Brasil.

Background: Dermatological diseases are among the primary causes of the demand for basic health care. Studies on the frequency of dermatoses are important for the proper management of health planning.

Objectives: To evaluate the nosological and behavioral profiles of dermatological consultations in Brazil. Read More

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September 2018

Leprosy: clinical and epidemiological study in patients above 60 years in Espírito Santo State - Brazil.

An Bras Dermatol 2018 Nov/Dec;93(6):824-828

Discipline of Dermatology, Universidade Federal do Maranhão, São Luís (MA), Brazil.

Background: Leprosy is a chronic infectious disease that is endemic in Brazil and little studied in patients over 60 years old.

Objective: The aim of this study was the epidemiological and clinical description of cases of leprosy in individuals older than 60 years, notified in the State of Espírito Santo - Brazil.

Methods: It was an observational, descriptive and retrospective study of leprosy patients notified between 2001 and 2011. Read More

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VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population.

PLoS Negl Trop Dis 2018 Nov 27;12(11):e0006823. Epub 2018 Nov 27.

Stanley Browne Laboratory, The Leprosy Mission Trust India, The Leprosy Mission Community Hospital, Nand Nagari, New Delhi, Delhi, India.

Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae and mainly affects skin, peripheral nerves. Vitamin D receptor (VDR) gene polymorphism has been found to be associated with leprosy. Vitamin D has been shown to control several host immunomodulating properties through VDR gene. Read More

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November 2018
1 Read

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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October 2018
2 Reads

Major Histocompatibility Complex and Psoriasis.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S79-S80

The Institute of Dermatology and Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, China. Electronic address:

Major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) in humans, is one of the most genetically diverse regions in the genome of various species. The human MHC contains about 400 genes in a ∼7.6-Mb span located on the short arm of the chromosomal region 6p21. Read More

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December 2018
5 Reads

Wide Awake Tendon Transfers in Leprosy Patients in India.

Hand Clin 2019 Feb;35(1):67-84

Division of Plastic Surgery, Dalhousie University, Dalhousie Medicine New Brunswick, Suite C204, 600 Main Street, Saint John, New Brunswick E2K 1J5, Canada.

Dr Akbar Khan began using the wide awake local anesthesia no tourniquet (WALANT) technique for leprosy tendon transfers in the summer of 2015 at the Damien Foundation Hospital in Nellore, India. This article summarizes his first 18 months of experience and describes 5 of his operations. He found that WALANT provides effective anesthesia with good visibility for leprosy tendon transfers. Read More

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February 2019
3 Reads

Falknor's needling method as a potential immunotherapy in palmo-plantar warts.

Indian J Dermatol Venereol Leprol 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Venereology and Leprosy, GMC, Kota, Rajasthan, India.

Background And Aim: Treatment of palmoplantar warts is a challenge for dermatologists. We aimed to study the efficacy and safety of Falknor's needling method in palmoplantar warts.

Methods: In an open, nonrandomized study, the index wart of eligible patients was punctured several times with a 26-gauge needle to produce a "beefy" red wound. Read More

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November 2018
5 Reads

Bilateral facial circumscribed morphea: The first case report.

J Dtsch Dermatol Ges 2018 Nov 22. Epub 2018 Nov 22.

Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.

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November 2018
1 Read

Barriers to Promoting Advance Care Planning for Residents Living in a Sanatorium for Hansen's Disease: A Qualitative Study of Residents and Staff in Japan.

Asian Bioeth Rev 2018 3;10(3):199-217. Epub 2018 Aug 3.

2Advanced Research Center for Human Sciences, Waseda University, Tokyo, Japan.

In Japan, most residents with Hansen's disease (leprosy) live in dedicated sanatoria because of an established quarantine policy, even after being cured of the primary disease. They suffer from secondary diseases and are advancing in age, and advance care planning (ACP) is increasingly crucial for them to live their lives with dignity in a sanatorium. In this study, we have three aims: (1) to understand how to promote communication about their wishes for medical treatment, care, and recuperation; (2) to identify required assistance; and (3) to explore how to promote ACP in a sanatorium. Read More

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August 2018
2 Reads

Discrimination of and in clinical isolates/specimens by multiple PCR assay and prediction of drug susceptibility.

J Clin Microbiol 2018 Nov 21. Epub 2018 Nov 21.

Dental School, Okayama University, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, and Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Next generation sequencing technology revealed the existence of more viable but non-culturable bacteria (VBNC) relative to culturable bacteria (1).…. Read More

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November 2018

Novel nano-sized chitosan amphotericin B formulation with considerable improvement against Leishmania major.

Nanomedicine (Lond) 2018 Nov 22. Epub 2018 Nov 22.

Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran.

Aim: Improvement in the treatment of Leishmania major's pathological effects through increasing the dose of amphotericin B loaded into nanochitosan.

Materials & Methods: The phase separation method was used for nanochitosan synthesis and amphotericin loading. Also a novel solvent was designed and the nanodrug efficacy was evaluated in vitro and in vivo (pathology) environments. Read More

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November 2018
9 Reads

Organization of oversight for integrated control of neglected tropical diseases within Ministries of Health.

PLoS Negl Trop Dis 2018 Nov 21;12(11):e0006929. Epub 2018 Nov 21.

Georgetown University Medical Center, Center for Global Health Science and Security, Washington, District of Columbia, United States of America.

Background: Neglected tropical diseases (NTDs) are communicable diseases that impact approximately 1 billion people, but receive relatively little research, funding, and attention. Many NTDs have similar treatments, epidemiology, and geographic distribution, and as a result, the integration of control efforts can improve accountability, efficiency, and cost-effectiveness of programs. Here, we examine the landscape of efforts towards NTD integration across countries with the highest burden of disease, and review the administrative management of integration in order to identify approaches and pathways for integration. Read More

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November 2018
1 Read

Therapeutic Potential of : A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects.

Front Pharmacol 2018 22;9:1177. Epub 2018 Oct 22.

Department of Pharmacology, School of Pharmacy and Technology Management, SVKM's NMIMS, Dhule, India.

(Cucurbitaceae), a perennial plant grows mainly in India, Southeast Asia, China, Japan, Egypt, and other parts of Africa, it is widely used in the traditional Indian medicinal system to treat various health conditions. The plant has been used in jaundice, diabetes, hemorrhoids, dysentery, headache, ringworm infection, and leprosy. More than 50 chemical compounds have been isolated from a plant which mainly comprises flavonoids, anthraquinones, proteins, fatty acids, saponin triterpene, volatile components, and other phytoconstituents. Read More

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October 2018
5 Reads

Intervention Packages for Early Visceral Leishmaniasis Case Detection and Sandfly Control in Bangladesh: A Comparative Analysis.

Am J Trop Med Hyg 2018 Nov 19. Epub 2018 Nov 19.

Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

We compared the efficacy of three intervention packages for active case detection (ACD) of visceral leishmaniasis (VL)/post-kala-azar dermal leishmaniasis (PKDL) combined with sandfly control around an index case. The packages were 1) no kala-azar transmission activity involving indoor residual spraying (IRS) with deltamethrin, peri-domestic deployment of larvicide with temephos, and house-to-house search for cases; 2) fever camp (FC) plus durable wall lining (DWL) with deltamethrin; and 3) FC plus insecticide (deltamethrin) impregnated bed-nets (ITN) around an index case. Fever camp includes 1-day campaign at the village level to screen and diagnose VL, PKDL, leprosy, malaria, and tuberculosis among residents with chronic fever or skin disease. Read More

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November 2018
2 Reads

Contact dermatitis caused by ballpoint pen ink: A problem for a schoolchild.

Contact Dermatitis 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Venereology and Leprosy, ESI-PGIMSR Hospital, Delhi, India.

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November 2018
1 Read

Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration.

Pharmaceutics 2018 Nov 17;10(4). Epub 2018 Nov 17.

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.

Clofazimine (CFZ) is a broad spectrum antimycobacterial agent recommended by the World Health Organization as a first line treatment for leprosy and second line treatment for multidrug resistant tuberculosis. Oral administration of CFZ leads to a red skin pigmentation side effect. Since CFZ is a weakly basic, red phenazine dye, the skin pigmentation side effect results from lipophilic partitioning of the circulating, free base (neutral) form of CFZ into the skin. Read More

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November 2018
1 Read

Father Adam Wiśniewski, MD, and his work for lepromatous patients in India.

Clin Dermatol 2018 Nov - Dec;36(6):779-784. Epub 2018 Jun 10.

Student, Medical Faculty of the University of Warmia and Mazury, Olsztyn, Poland.

Father Adam Wiśniewski (1913-1987), who was a Pallottine and a medical doctor with specialization in tropical diseases, devoted his life to helping and curing leprosy patients in India. His life proved difficult and varied. He began his medical studies during World War II in occupied Warsaw. Read More

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Household Air Pollution Is Associated with Chronic Cough but Not Hemoptysis after Completion of Pulmonary Tuberculosis Treatment in Adults, Rural Eastern Democratic Republic of Congo.

Int J Environ Res Public Health 2018 Nov 15;15(11). Epub 2018 Nov 15.

Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, 300 Leuven, Belgium.

Little is known about the respiratory health damage related to household air pollution (HAP) in survivors of pulmonary tuberculosis (PTB). In a population-based cross-sectional study, we determined the prevalence and associated predictors of chronic cough and hemoptysis in 441 randomly selected PTB survivors living in 13 remote health zones with high TB burden in the South Kivu province of the Democratic Republic of Congo (DRC). Trained community and health-care workers administered a validated questionnaire. Read More

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November 2018
6 Reads

Association of non-tuberculous mycobacteria with Mycobacterium leprae in environment of leprosy endemic regions in India.

Infect Genet Evol 2018 Nov 13. Epub 2018 Nov 13.

The Leprosy Mission Trust India, Stanley Browne Laboratory, TLM community Hospital Nand Nagari, New Delhi 110093, India.

Non-tuberculous mycobacteria (NTM) are environmental mycobacteria found ubiquitously in nature. The present study was conducted to find out the presence of various species of NTM in leprosy endemic region along with Mycobacterium (M) leprae. Water and wet soil samples from the periphery of ponds used by the community were collected from districts of Purulia of West Bengal and Champa of Chhattisgarh, India. Read More

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November 2018
3 Reads

Leprosy services in primary health care in India: comparative economic cost analysis of two public-health settings.

Trop Med Int Health 2018 Nov 16. Epub 2018 Nov 16.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Objectives: The WHO recommends inclusion of post-exposure chemoprophylaxis with single-dose rifampicin in national leprosy control programmes. The objective was to estimate the cost of leprosy services at primary care level in two different public-health settings.

Methods: Ingredient-based costing was performed in eight primary health centres (PHCs) purposively selected in the Union Territory of Dadra and Nagar Haveli (DNH) and the Umbergaon block of Valsad district, Gujarat, India. Read More

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November 2018
4 Reads

Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions.

BMC Infect Dis 2018 Nov 15;18(1):576. Epub 2018 Nov 15.

Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, PA, Brazil.

Background: Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages in leprosy or other infectious diseases caused by mycobacteria has not yet been clearly characterized. This study aimed to investigate the presence and potential role of M4 macrophages in the immunopathology of leprosy. Read More

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November 2018
1 Read

Integrated Management of Skin NTDs-Lessons Learned from Existing Practice and Field Research.

Authors:
Rie R Yotsu

Trop Med Infect Dis 2018 Nov 14;3(4). Epub 2018 Nov 14.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8102, Japan.

Integration of neglected tropical diseases (NTDs) into the public health agenda has been a priority in global health for the last decade. Because a number of these diseases share not only the geographical distribution, but also a common feature which is skin involvement, bringing together a sub-group of 'skin NTDs' is one way forward to promote further integration among NTDs. With these diseases, which include leprosy, Buruli ulcer, yaws, mycetoma, lymphatic filariasis, and leishmaniasis, patients may be left with life-long deformities and disabilities when diagnosis and treatment are delayed. Read More

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November 2018
1 Read

Cutaneous Mycobacterial Infections.

Clin Microbiol Rev 2018 Jan 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

SUMMARYHumans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

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January 2018
3 Reads