520 results match your criteria Leprosy Neuropathy of


The Correlation of Semmes-Weinstein Monofilament Test with the Level of P-75 Neurotrophin as Marker of Nerve Damage in Leprosy.

Clin Cosmet Investig Dermatol 2020 15;13:399-404. Epub 2020 Jun 15.

Orthopaedic and Traumatology Department, Faculty of Medicine, Universitas Brawijaya, Saiful Anwar Regional General Hospital, Malang, Indonesia.

Introduction: Leprosy is a chronic infectious disease caused by that causes damage to the peripheral nerve, particularly Schwann cells. Treatment is useful only to kill bacteria but not to recover peripheral nerve damage. However, early detection of peripheral nerve damage is necessary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CCID.S251356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304681PMC

Leprosy: A rare case of infectious peripheral neuropathy in the United States.

IDCases 2020 14;20:e00765. Epub 2020 Apr 14.

University of Massachusetts Medical School, Baystate Medical Center, United States.

Peripheral neuropathy can be the initial presentation of leprosy. Diagnosis can be challenging unless skin manifestations are recognized. Skin biopsy and Fite staining are the keys to the diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2020.e00765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200790PMC

Appropriately Selected Nerve in Suspected Leprous Neuropathy Yields High Positive Results for DNA by Polymerase Chain Reaction Method.

Am J Trop Med Hyg 2020 Apr 13. Epub 2020 Apr 13.

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Identification of DNA by polymerase chain reaction (PCR) is a reliable and an affordable method to confirm leprosy. DNA from 87 nerve samples (56 from paraffin blocks and 26 fresh samples) was extracted. DNA was amplified by PCR from 80/87 (92%) specimens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.19-0746DOI Listing
April 2020
2.699 Impact Factor

Pathological, ultrasonographic, and electrophysiological characterization of clinically diagnosed cases of pure neuritic leprosy.

J Peripher Nerv Syst 2020 Jun 23;25(2):191-203. Epub 2020 Apr 23.

Department of Neurology, KGMU, Lucknow, India.

A subset of neuritic form of leprosy, called pure neuritic leprosy (PNL), seen in a minority of leprosy patients, is characterized by peripheral neuropathy without skin lesions and an absence of acid-fast bacilli on skin smears. Patients with PNL are often started on drug therapy without confirmation of diagnosis. We, therefore, did a prospective study of clinically diagnosed PNL patients with correlation of ultrasonographic and biopsy findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jns.12372DOI Listing
June 2020
2.758 Impact Factor

Orthopedic Surgical Foot Management in Hansen Disease.

Orthop Clin North Am 2020 Apr;51(2):279-291

Federal University Hospital of Rio de Janeiro (UFRJ/HUCFF), Rua Rodolpho Paulo Rocco, 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro - RJ CEP 21941-913, Brazil.

Hansen disease remains a common problem worldwide with 750,000 new cases diagnosed each year. Nerve injury is a central feature of the pathogenesis because of the unique tendency of Mycobacterium leprae to invade Schwann cells and the peripheral nervous system, that can be permanent and develop into disabilities. The orthopedic surgeon has an important role in the management of neuropathy, performing surgical release of the tibial and common peroneal nerves in potentially constricting areas, thus providing a better environment for nerve function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ocl.2019.11.012DOI Listing

Cytokine Levels in Neural Pain in Leprosy.

Front Immunol 2020 24;11:23. Epub 2020 Jan 24.

Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.

Pain is a frequent symptom in leprosy patients. It may be predominantly nociceptive, as in neuritis, or neuropathic, due to injury or nerve dysfunction. The differential diagnosis of these two forms of pain is a challenge in clinical practice, especially because it is quite common for a patient to suffer from both types of pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992577PMC
January 2020

Sarcoidosis with cutaneous perineural granulomas and neurological manifestations: A potential mimicker of leprosy.

J Cutan Pathol 2020 Jul 13;47(7):625-627. Epub 2020 Feb 13.

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Sarcoidosis is a granulomatous condition with diverse clinical presentations, including neurological findings. It was previously hypothesized that perineural sarcoidal granulomas in the skin may be an explanation of small-fiber neuropathy. Herein, we present a case of a 55 year old female with anesthetic cutaneous lesions mimicking leprosy clinically and histopathologically and discuss the importance of this differential diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13660DOI Listing

Clinical characteristics of neuropathic pain in leprosy and associated somatosensory profiles: a deep phenotyping study in India.

Pain Rep 2019 Nov-Dec;4(6):e743. Epub 2019 Dec 6.

Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom.

This study investigated the clinical characteristics and somatosensory profiles of patients suffering from leprosy in Mumbai, India. A cross-sectional deep profiling study was conducted in 86 patients with leprosy (with and without pain) using an extensive battery of phenotyping measures including structured clinical examination, psychological state (General Health Questionnaire [GHQ-12]), and a quality-of-life condition-specific instrument (Brief Pain Inventory-short form). Quantitative sensory testing was performed according to the protocol of the German Research Network on Neuropathic Pain (DFNS) to assess the somatosensory profiles in the ulnar nerve innervation territory of all participants (dorsum of the hand). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PR9.0000000000000743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903357PMC
December 2019

Disabilities in leprosy: an open, retrospective analyses of institutional records.

An Bras Dermatol 2020 Jan - Feb;95(1):52-56. Epub 2019 Dec 28.

Consultant Dermatologist, Twachha Skin Clinic, Ahmedabad, Gujarat, India.

Background And Objectives: Leprosy remains a leading cause of peripheral neuropathy and disability in the world. Primary objective of the study was to determine the incidence of deformities present at a time of diagnosis and new deformities that patients develop over follow up period.

Material And Methods: An open, retrospective cohort study was performed at a tertiary medical center in western India. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abd.2019.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058852PMC

Evidence for Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India.

Am J Trop Med Hyg 2020 03;102(3):547-552

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance to rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within the folP1, rpoB, and gyrA gene regions of the genome predominantly in the neural form of leprosy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.19-0390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056437PMC
March 2020
2.699 Impact Factor

Case report: Hansen's disease in an active duty soldier presenting with type 1 reversal reaction.

MSMR 2019 Dec;26(12):2-6

Leprosy, or Hansen's disease (HD), is caused by the bacterium and is a significant cause of morbidity worldwide. Clinical manifestations range from isolated skin rash to severe peripheral neuropathy. Treatment involves a prolonged course of multiple antimicrobials. Read More

View Article

Download full-text PDF

Source
December 2019

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.

Sci Rep 2019 11 29;9(1):17931. Epub 2019 Nov 29.

Dept. of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

Early diagnosis of leprosy is challenging, particularly its inflammatory reactions, the major cause of irreversible neuropathy in leprosy. Current diagnostics cannot identify which patients are at risk of developing reactions. This study assessed blood RNA expression levels as potential biomarkers for leprosy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-54213-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884598PMC
November 2019

Ulcers in leprosy patients, an unrecognized clinical manifestation: a report of 8 cases.

BMC Infect Dis 2019 Nov 29;19(1):1013. Epub 2019 Nov 29.

Department of Dermatology, Hospital das Clínicas University of São Paulo Medical School, 255, Dr. Enéas de Carvalho Aguiar Ave, 3rd floor, São Paulo, Brazil.

Background: Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae. It is a polymorphic disease with a wide range of cutaneous and neural manifestations. Ulcer is not a common feature in leprosy patients, except during reactional states, Lucio's phenomenon (LP), or secondary to neuropathies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-4639-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884743PMC
November 2019

Neuritic Leprosy; An Intriguing Re-visit to a Forbidden Ailment.

Kathmandu Univ Med J (KUMJ) 2019 Jan.-Mar;17(65):73-76

Department of Neurosurgery, Upendra Devkota Memorial National Institute of Neurological and Allied Sciences, Bansbari, Kathmandu.

Leprosy is a chronic infectious disease that presents with varied manifestations. Pure neuritic leprosy is one of the rarest forms of the disease which is characterized by nerve involvement without the characteristic cutaneous stigmata. Eleven year old, healthy male presented with progressively increasing painful swelling at the medial aspect of the arm near to the right elbow joint with difficulty in extending right ring and little fingers at interphalangeal joint and numbness in the same region for last 1 year with no cutaneous abnormalities. Read More

View Article

Download full-text PDF

Source
February 2020
3 Reads

Reversible Cause of Neuropathy and Monoclonal Gammopathy of Renal Significance.

Am J Med 2020 05 9;133(5):576-579. Epub 2019 Nov 9.

Department of Nephrology, PGIMER, Chandigarh, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2019.10.017DOI Listing
May 2020
5.003 Impact Factor

Myelin breakdown favours Mycobacterium leprae survival in Schwann cells.

Cell Microbiol 2020 Jan 13;22(1):e13128. Epub 2019 Nov 13.

Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Leprosy neuropathy is a chronic degenerative infectious disorder of the peripheral nerve caused by the intracellular obligate pathogen Mycobacterium leprae (M. leprae). Among all nonneuronal cells that constitute the nerve, Schwann cells are remarkable in supporting M. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cmi.13128DOI Listing
January 2020

Neurological Complications of Leprosy.

Authors:
K H Vincent Lau

Semin Neurol 2019 08 18;39(4):462-471. Epub 2019 Sep 18.

Division of Neuromuscular Medicine, Department of Neurology, Boston Medical Center, Boston, Massachusetts.

Leprosy is a challenging international health concern. Despite tremendous efforts in reducing worldwide disease prevalence in the past decades, some countries remain endemic and are plagued by high levels of disability. The neurological complications of leprosy are varied and complex, with current research focused on evaluating tools for earlier diagnosis of neuropathy, especially in resource-limited countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1687884DOI Listing
August 2019
3 Reads

Fibrosis: a distinguishing feature in the pathology of neural leprosy.

Mem Inst Oswaldo Cruz 2019 5;114:e190056. Epub 2019 Aug 5.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, RJ, Brasil.

Background: Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers.

Objectives: The present study describes the frequency of fibrosis along with its characterisation and pathogenic development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0074-02760190056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684007PMC
September 2019
4 Reads

Leprosy presenting as remitting seronegative symmetrical synovitis with pitting oedema syndrome - a case report.

BMC Infect Dis 2019 May 22;19(1):455. Epub 2019 May 22.

Department of Rheumatology, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

Background: Leprosy typically manifests with skin and peripheral nerve involvement. Musculoskeletal complaints are the third most common, and can be the sole presenting manifestation. They range from arthralgia/arthritis in reactional states to full mimics of systemic rheumatic diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-4098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530132PMC
May 2019
8 Reads

Adverse events in patients with leprosy on treatment with thalidomide.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180385. Epub 2019 Apr 11.

Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic.

Methods: A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0385-2018DOI Listing
April 2019
22 Reads

Leprosy neuropathy masquerading as cellulitis.

Postgrad Med J 2019 Apr 27;95(1122):225-226. Epub 2019 Mar 27.

Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/postgradmedj-2019-136392DOI Listing
April 2019
8 Reads
1.549 Impact Factor

Neurosurgical treatment of leprosy neuropathy in a low-incidence, European country.

Neurol Sci 2019 Jul 22;40(7):1371-1375. Epub 2019 Mar 22.

Division of Neurosurgery, Department of Neuroscience (DINOGMI), Ospedale Policlinico San Martino-IST, University of Genoa, Largo Rosanna Benzi 10, 16132, Genoa, Italy.

Introduction: Leprosy is nowaday increasingly encountered in non-endemic countries. Nerve involvement is common. Swelling of the nerves may lead to entrapment neuropathy causing pain and neurological deficits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-019-03835-1DOI Listing
July 2019
4 Reads

Evaluation of the cutaneous sensation of the face in patients with different clinical forms of leprosy.

PLoS One 2019 14;14(3):e0213842. Epub 2019 Mar 14.

Postgraduate Program on Health Sciences, School of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.

Background: Leprosy can be considered to be the most common peripheral neuropathy of infectious etiology and constitutes a public health problem. The standard routine examination for assessing sensory impairment in leprosy neuropathy basically evaluates hands, feet and eyes. However, evaluation of facial cutaneous sensation is not routinely performed. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417732PMC
December 2019
3 Reads

Leprosy in a Midwestern Dermatology Clinic: Report of 9 Patients.

Mayo Clin Proc 2019 03 21;94(3):417-423. Epub 2019 Feb 21.

Department of Dermatology, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Objective: To describe the clinical features and epidemiology of leprosy in patients evaluated in a Midwestern dermatology clinic.

Patients And Methods: We performed a retrospective review of clinical and laboratory data from patients with leprosy who were evaluated in the Department of Dermatology at Mayo Clinic in Rochester, Minnesota, from January 1, 1994, through December 31, 2017.

Results: Nine patients, 7 male and 2 female, were identified, ranging in age from 15 to 63 years (mean age, 38 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mayocp.2018.11.022DOI Listing
March 2019
7 Reads

Brain and Spinal Cord Lesions in Leprosy: A Magnetic Resonance Imaging-Based Study.

Am J Trop Med Hyg 2019 04;100(4):921-931

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neurotropism and infiltration by of peripheral nerves causing neuropathy are well established, but reports of central nervous system (CNS) damage are exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities of the brain and spinal cord as well as lesions in nerve roots and plexus in leprosy patients. Eight patients aged between 17 and 41 years underwent detailed clinical, histopathological, and MRI evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.17-0945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447108PMC
April 2019
33 Reads
2.699 Impact Factor

MRI of radial cutaneous nerve abscess in recurrent neural leprosy.

BMJ Case Rep 2018 Dec 14;11(1). Epub 2018 Dec 14.

Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228704DOI Listing
December 2018
8 Reads

Human immunodeficiency virus neuropathy: A new mimicker of leprous neuropathy.

Indian J Sex Transm Dis AIDS 2018 Jan-Jun;39(1):59-60

Department of Skin and VD, JNU Institute for Medical Sciences and Research Centre, Jaipur, Rajasthan, India.

Peripheral neuropathy is usually the domain of the physician or neurologist. Still, many times patients land up in dermatology department with complaints such as sensory loss, paresthesia, and trophic ulcers. Usually, these patients are evaluated for leprosy and then referred to departments of internal medicine or neurology. Read More

View Article

Download full-text PDF

Source
http://www.ijstd.org/text.asp?2018/39/1/59/228646
Publisher Site
http://dx.doi.org/10.4103/ijstd.IJSTD_90_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111644PMC
September 2018
6 Reads

A 13-Year-Old with Coexistence of Gastric Volvulus and Leprosy: A Case Report of Two Rare Entities.

Case Rep Infect Dis 2018 14;2018:6125215. Epub 2018 Aug 14.

Mission Hospital, Asheville, NC, USA.

Leprosy, or Hansen's disease, is caused by infection with . It is a rare diagnosis within the continental United States. We present the case of a 13-year-old immigrant from the Marshall Islands who presented with recurrent nausea, vomiting, and abdominal pain which are found to be due to intermittent gastric volvulus. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/criid/2018/6125215/
Publisher Site
http://dx.doi.org/10.1155/2018/6125215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112268PMC
August 2018
10 Reads

[A case series of pure neural leprosy in patients diagnosed in a specialized center for the control of Hansen's disease in Colombia].

Biomedica 2018 06 15;38(2):153-161. Epub 2018 Jun 15.

Línea de Investigación en Lepra, Instituto Colombiano de Medicina Tropical, Facultad de Medicina, Universidad CES, Medellín, Colombia Escuela de Graduados, Universidad CES, Medellín, Colombia.

Pure neural leprosy, defined as a peripheral neuropathy in which the patient has no skin lesions, is difficult to diagnose. Its verification by bacteriological index and histopathology is not possible in the majority of the patients.We describe four cases of pure neural leprosy diagnosed by clinical criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7705/biomedica.v38i0.3690DOI Listing
June 2018
3 Reads

Lessons From Leprosy: Peripheral Neuropathies and Deformities in Chronic Demyelinating Diseases.

J Hand Surg Am 2019 May 1;44(5):411-415. Epub 2018 Sep 1.

Peripheral Nerve Research Lab, Gillespie Neuroscience Research Facility, Irvine, Orange, CA; Department of Orthopaedic Surgery, University of California, Irvine, Orange, CA. Electronic address:

In light of the World Health Organization's push to accelerate progress toward a leprosy-free world by 2020, it is fitting to look back on the evolution of progress in treating lepromatous neuropathy and limb deformities. To date, no surgeon has had as great an impact on the understanding and treatment of this disease as Dr Paul Brand. Before Dr Brand's accomplishments, few surgeons participated in the management of the deformed leprous patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhsa.2018.07.007DOI Listing
May 2019
48 Reads

Saphenous nerve transfer: A new approach to restore sensation of the sole.

J Plast Reconstr Aesthet Surg 2018 Dec 2;71(12):1704-1710. Epub 2018 Aug 2.

Plastic surgery unit, Department of Surgery, N.S.C.B. Government Medical College, Jabalpur, 482003 MP India.

Background: Loss of protective sensation of the sole may lead to repeated trauma, chronic nonhealing ulcers, and even amputation. Saphenous nerve (SN) to posterior tibial nerve (PTN) transfer can restore sensation of the sole.

Method: This study was conducted in a tertiary referral center in Central India. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjps.2018.07.011DOI Listing
December 2018
5 Reads

Mandating nerve biopsy: A step towards personalizing therapy in pure neuritic leprosy.

J Peripher Nerv Syst 2018 Sep 27;23(3):190-196. Epub 2018 Aug 27.

Department of Neurology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

Pure neuritic leprosy (PNL) accounts for 5% to 10% of leprosy patients who usually present with asymmetrical neuropathy in the absence of lepra bacilli on slit-skin smears. However, nerve biopsies in PNL lack appropriate categorization in current immunologic terms. We aimed to classify nerve biopsies according to the immune spectrum of leprosy and assess the role of histologic classification of nerve biopsies in treating PNL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jns.12283DOI Listing
September 2018
13 Reads

Guillain-Barre Syndrome: A Rare Presentation of Borderline Tuberculoid Leprosy with Type 1 Lepra Reaction.

J Neurosci Rural Pract 2018 Jul-Sep;9(3):423-425

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Guillain-Barre syndrome (GBS) is an autoimmune polyradiculoneuropathy usually preceded by respiratory tract or gastrointestinal infection. The pathogenesis in GBS is based on molecular mimicry mechanism. Hansen's disease is common in India and is the most common infectious cause of neuropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jnrp.jnrp_510_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050757PMC
August 2018
19 Reads

Rheumatoid arthritis-like features in Hansen disease: A case report.

Medicine (Baltimore) 2018 Jul;97(29):e11590

Department of Rheumatology, Southwest Hospital, the Third Military Medical University (Army Military Medical University), Chongqing, China.

Rationale: Hansen disease is an infectious chronic disease with various clinical manifestations. Its joint performance may easily mimic rheumatoid arthritis.

Patient Concerns: We report a case of a 57-year-old woman diagnosed with Hansen disease 10 years ago, who suffered from joints swelling, pain and joints deformities of both hands for 19 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000011590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086502PMC
July 2018
4 Reads

Peripheral nerve abnormality in HIV leprosy patients.

PLoS Negl Trop Dis 2018 07 18;12(7):e0006633. Epub 2018 Jul 18.

Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil.

Background: The geographical overlap of HIV (human immunodeficiency virus) and leprosy infection has become increasingly frequent and worrying, bringing many clinical issues. Peripheral neuropathy is very frequent in leprosy because of the predilection of its etiologic agent by Schwann cells of the peripheral nervous system, and it also affects individuals with HIV as one of the most common neurological manifestations.

Methodology/principal Findings: The present study compared a cohort of 63 patients diagnosed with leprosy and coinfected with HIV with a cohort of 64 patients with leprosy alone, who were followed at the outpatient clinic of the Nucleus of Tropical Medicine of the Federal University of Pará, Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0006633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066254PMC
July 2018
26 Reads

Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy.

PLoS Negl Trop Dis 2018 07 2;12(7):e0006610. Epub 2018 Jul 2.

Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, England.

Objectives: Neuropathic pain (NP) can occur as a chronic complication of leprosy neuropathy. NP epidemiology and its impact on patients have not been well documented. This study investigates NP prevalence and impact in the years after patients are declared "released from treatment" (RFT) following multidrug therapy (MDT) completion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0006610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044550PMC
July 2018
10 Reads

Correlates of immune exacerbations in leprosy.

Authors:
Annemieke Geluk

Semin Immunol 2018 10 24;39:111-118. Epub 2018 Jun 24.

Dept. of Infectious Diseases, LUMC, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

Leprosy is still a considerable health threat in pockets of several low and middle income countries worldwide where intense transmission is witnessed, and often results in irreversible disabilities and deformities due to delayed- or misdiagnosis. Early detection of leprosy represents a substantial hurdle in present-day leprosy health care. The dearth of timely diagnosis has, however, particularly severe consequences in the case of inflammatory episodes, designated leprosy reactions, which represent the major cause of leprosy-associated irreversible neuropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.smim.2018.06.003DOI Listing
October 2018
37 Reads

Footwear in the causation and prevention of foot ulcers in diabetes mellitus.

Natl Med J India 2017 Sep-Oct;30(5):255-261

Schieffelin Leprosy Research and Training Centre, Karigiri 632106, Tamil Nadu, India.

Background.: Inappropriate footwear may be a major cause of foot ulceration among patients with diabetic neuropathy in India. No study has specifically examined the types of footwear or its components in patients with diabetes mellitus and their role in causing foot ulcers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0970-258X.234391DOI Listing
December 2018
8 Reads

Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy.

Front Immunol 2018 4;9:1223. Epub 2018 Jun 4.

Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Leprosy reactions are responsible for incapacities in leprosy and represent the major cause of permanent neuropathy. The identification of biomarkers able to identify patients more prone to develop reaction could contribute to adequate clinical management and the prevention of disability. Reversal reaction may occur in unstable borderline patients and also in lepromatous patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994478PMC
August 2019
15 Reads

Anti-Lipoarabinomannan-Specific Salivary IgA as Prognostic Marker for Leprosy Reactions in Patients and Cellular Immunity in Contacts.

Front Immunol 2018 30;9:1205. Epub 2018 May 30.

Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Leprosy causes the most common peripheral neuropathy of infectious etiology, posing an important public health problem worldwide. Understanding the molecular and immunological mechanisms of nerve damage induced by is mandatory to develop tools for early diagnosis and preventive measures. The phenolic glycolipid 1 (PGL-1) and lipoarabinomannan (LAM) antigens are major components of the bacterial surface and are implicated on leprosy immunopathogenesis and neural damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990868PMC
August 2019
5 Reads

Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil.

Sci Rep 2018 06 8;8(1):8783. Epub 2018 Jun 8.

Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Leprosy is a chronic infectious peripheral neuropathy that is caused by Mycobacterium leprae, and the skin is one of its preferred target sites. However, the effects of this infection on the skin microbiome remain largely unexplored. Here, we characterize and compare the lesional and non-lesional skin microbiomes of leprosy patients and healthy individuals through the deep sequencing of 16 S rRNA genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-27074-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993821PMC
June 2018
27 Reads

Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update.

Front Immunol 2018 7;9:939. Epub 2018 May 7.

Center of Health and Biological Sciences, State University of Para, Belem, Brazil.

Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.00939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949531PMC
July 2019
9 Reads

Molecular, immunological and neurophysiological evaluations for early diagnosis of neural impairment in seropositive leprosy household contacts.

PLoS Negl Trop Dis 2018 05 21;12(5):e0006494. Epub 2018 May 21.

National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, School of Medicine, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.

Background: Household contacts constitute the highest risk group for leprosy development, and despite significant progress in the disease control, early diagnosis remains the primary goals for leprosy management programs.

Methods: We have recruited 175 seropositive and 35 seronegative household contacts from 2014 to 2016, who were subjected to an extensive protocol that included clinical, molecular (peripheral blood qPCR, slit-skin smear qPCR, skin biopsy qPCR) and electroneuromyographic evaluations.

Results/principal Findings: The positivity of peripheral blood qPCR of seropositive contacts was 40. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0006494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983863PMC
May 2018
36 Reads

Neuropathic pain in leprosy: symptom profile characterization and comparison with neuropathic pain of other etiologies.

Pain Rep 2018 Mar 23;3(2):e638. Epub 2018 Feb 23.

Neurology Departament, Pain Center, University of Sao Paulo, Brazil.

Introduction: Previous studies reported a high prevalence of neuropathic pain in leprosy, being especially present in "pharmacologically cured" patients. The presence of neuropathic pain in leprosy poses a supplementary burden in patient's quality of life, daily activities, and mood.

Objectives: The aim of this study was to assess whether neuropathic pain in leprosy has similar symptom profile as neuropathic pain of other etiologies and to retrospectively assess the efficacy of neuropathic pain medications regularly prescribed to leprosy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PR9.0000000000000638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902246PMC
March 2018
18 Reads

Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study.

J Peripher Nerv Syst 2018 06 7;23(2):120-123. Epub 2018 May 7.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Chronic polyneuropathy is a disabling condition of the peripheral nerves, characterized by symmetrical sensory motor symptoms and signs. There is paucity of studies on the etiological spectrum of polyneuropathy and its impact on quality of life (QoL). The present cross-sectional study in a referral based tertiary care center in North India found diabetic neuropathy as the commonest cause (25. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jns.12269DOI Listing
June 2018
8 Reads

Genetic variants, structural, and functional changes of Myelin Protein Zero and Mannose-Binding Lectin 2 protein involved in immune response and its allelic transmission in families of patients with leprosy in Colombia.

Infect Genet Evol 2018 07 5;61:215-223. Epub 2018 Apr 5.

Colombian Institute of Tropical Medicine (ICMT), CES University, Cra. 43 A # 52 Sur 99, Sabaneta, Antioquia, Colombia; School of Medicine, CES University, Cl. 10 #22 - 04, Medellín, Antioquia, Colombia; Graduate School, CES University, Cl. 10 #22 - 04, Medellín, Antioquia, Colombia. Electronic address:

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Genetic factors associated with immune response contribute to infection development and disease. M. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2018.04.002DOI Listing
July 2018
32 Reads

Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain.

Am J Trop Med Hyg 2018 06 29;98(6):1609-1613. Epub 2018 Mar 29.

Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Brazil.

Neural pain is a frequent symptom in leprosy disease. There is a paucity of data regarding neural pain diagnostics resulting in common prescriptive errors when neuritis is confused with neuropathic or mixed nociceptive-neuropathic pain. The present study identified important demographic, clinical, and neurophysiological features of 42 leprosy neuropathy patients presenting neuropathic pain (NP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.17-0817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086157PMC
June 2018
13 Reads