497 results match your criteria Leprosy Neuropathy of


Adverse events in patients with leprosy on treatment with thalidomide.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180385. Epub 2019 Apr 11.

Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic.

Methods: A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Read More

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http://dx.doi.org/10.1590/0037-8682-0385-2018DOI Listing

Leprosy neuropathy masquerading as cellulitis.

Postgrad Med J 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK.

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http://dx.doi.org/10.1136/postgradmedj-2019-136392DOI Listing
March 2019
1 Read
1.549 Impact Factor

Neurosurgical treatment of leprosy neuropathy in a low-incidence, European country.

Neurol Sci 2019 Mar 22. Epub 2019 Mar 22.

Division of Neurosurgery, Department of Neuroscience (DINOGMI), Ospedale Policlinico San Martino-IST, University of Genoa, Largo Rosanna Benzi 10, 16132, Genoa, Italy.

Introduction: Leprosy is nowaday increasingly encountered in non-endemic countries. Nerve involvement is common. Swelling of the nerves may lead to entrapment neuropathy causing pain and neurological deficits. Read More

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http://dx.doi.org/10.1007/s10072-019-03835-1DOI Listing
March 2019
1 Read

Evaluation of the cutaneous sensation of the face in patients with different clinical forms of leprosy.

PLoS One 2019 14;14(3):e0213842. Epub 2019 Mar 14.

Postgraduate Program on Health Sciences, School of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.

Background: Leprosy can be considered to be the most common peripheral neuropathy of infectious etiology and constitutes a public health problem. The standard routine examination for assessing sensory impairment in leprosy neuropathy basically evaluates hands, feet and eyes. However, evaluation of facial cutaneous sensation is not routinely performed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417732PMC
March 2019
1 Read

Leprosy in a Midwestern Dermatology Clinic: Report of 9 Patients.

Mayo Clin Proc 2019 Mar 21;94(3):417-423. Epub 2019 Feb 21.

Department of Dermatology, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Objective: To describe the clinical features and epidemiology of leprosy in patients evaluated in a Midwestern dermatology clinic.

Patients And Methods: We performed a retrospective review of clinical and laboratory data from patients with leprosy who were evaluated in the Department of Dermatology at Mayo Clinic in Rochester, Minnesota, from January 1, 1994, through December 31, 2017.

Results: Nine patients, 7 male and 2 female, were identified, ranging in age from 15 to 63 years (mean age, 38 years). Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.11.022DOI Listing
March 2019
1 Read

Brain and Spinal Cord Lesions in Leprosy: A Magnetic Resonance Imaging-Based Study.

Am J Trop Med Hyg 2019 Apr;100(4):921-931

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neurotropism and infiltration by of peripheral nerves causing neuropathy are well established, but reports of central nervous system (CNS) damage are exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities of the brain and spinal cord as well as lesions in nerve roots and plexus in leprosy patients. Eight patients aged between 17 and 41 years underwent detailed clinical, histopathological, and MRI evaluation. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447108PMC
April 2019
6 Reads
2.699 Impact Factor

Human immunodeficiency virus neuropathy: A new mimicker of leprous neuropathy.

Indian J Sex Transm Dis AIDS 2018 Jan-Jun;39(1):59-60

Department of Skin and VD, JNU Institute for Medical Sciences and Research Centre, Jaipur, Rajasthan, India.

Peripheral neuropathy is usually the domain of the physician or neurologist. Still, many times patients land up in dermatology department with complaints such as sensory loss, paresthesia, and trophic ulcers. Usually, these patients are evaluated for leprosy and then referred to departments of internal medicine or neurology. Read More

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http://www.ijstd.org/text.asp?2018/39/1/59/228646
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http://dx.doi.org/10.4103/ijstd.IJSTD_90_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111644PMC
September 2018
2 Reads

A 13-Year-Old with Coexistence of Gastric Volvulus and Leprosy: A Case Report of Two Rare Entities.

Case Rep Infect Dis 2018 14;2018:6125215. Epub 2018 Aug 14.

Mission Hospital, Asheville, NC, USA.

Leprosy, or Hansen's disease, is caused by infection with . It is a rare diagnosis within the continental United States. We present the case of a 13-year-old immigrant from the Marshall Islands who presented with recurrent nausea, vomiting, and abdominal pain which are found to be due to intermittent gastric volvulus. Read More

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https://www.hindawi.com/journals/criid/2018/6125215/
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http://dx.doi.org/10.1155/2018/6125215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112268PMC
August 2018
5 Reads

[A case series of pure neural leprosy in patients diagnosed in a specialized center for the control of Hansen's disease in Colombia].

Biomedica 2018 06 15;38(2):153-161. Epub 2018 Jun 15.

Línea de Investigación en Lepra, Instituto Colombiano de Medicina Tropical, Facultad de Medicina, Universidad CES, Medellín, Colombia Escuela de Graduados, Universidad CES, Medellín, Colombia.

Pure neural leprosy, defined as a peripheral neuropathy in which the patient has no skin lesions, is difficult to diagnose. Its verification by bacteriological index and histopathology is not possible in the majority of the patients.We describe four cases of pure neural leprosy diagnosed by clinical criteria. Read More

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http://dx.doi.org/10.7705/biomedica.v38i0.3690DOI Listing

Lessons From Leprosy: Peripheral Neuropathies and Deformities in Chronic Demyelinating Diseases.

J Hand Surg Am 2018 Aug 31. Epub 2018 Aug 31.

Peripheral Nerve Research Lab, Gillespie Neuroscience Research Facility, Irvine, Orange, CA; Department of Orthopaedic Surgery, University of California, Irvine, Orange, CA. Electronic address:

In light of the World Health Organization's push to accelerate progress toward a leprosy-free world by 2020, it is fitting to look back on the evolution of progress in treating lepromatous neuropathy and limb deformities. To date, no surgeon has had as great an impact on the understanding and treatment of this disease as Dr Paul Brand. Before Dr Brand's accomplishments, few surgeons participated in the management of the deformed leprous patient. Read More

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http://dx.doi.org/10.1016/j.jhsa.2018.07.007DOI Listing
August 2018
32 Reads

Mandating nerve biopsy: A step towards personalizing therapy in pure neuritic leprosy.

J Peripher Nerv Syst 2018 Sep 27;23(3):190-196. Epub 2018 Aug 27.

Department of Neurology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

Pure neuritic leprosy (PNL) accounts for 5% to 10% of leprosy patients who usually present with asymmetrical neuropathy in the absence of lepra bacilli on slit-skin smears. However, nerve biopsies in PNL lack appropriate categorization in current immunologic terms. We aimed to classify nerve biopsies according to the immune spectrum of leprosy and assess the role of histologic classification of nerve biopsies in treating PNL. Read More

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http://dx.doi.org/10.1111/jns.12283DOI Listing
September 2018
4 Reads

Guillain-Barre Syndrome: A Rare Presentation of Borderline Tuberculoid Leprosy with Type 1 Lepra Reaction.

J Neurosci Rural Pract 2018 Jul-Sep;9(3):423-425

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Guillain-Barre syndrome (GBS) is an autoimmune polyradiculoneuropathy usually preceded by respiratory tract or gastrointestinal infection. The pathogenesis in GBS is based on molecular mimicry mechanism. Hansen's disease is common in India and is the most common infectious cause of neuropathy. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_510_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050757PMC
August 2018
11 Reads

Rheumatoid arthritis-like features in Hansen disease: A case report.

Medicine (Baltimore) 2018 Jul;97(29):e11590

Department of Rheumatology, Southwest Hospital, the Third Military Medical University (Army Military Medical University), Chongqing, China.

Rationale: Hansen disease is an infectious chronic disease with various clinical manifestations. Its joint performance may easily mimic rheumatoid arthritis.

Patient Concerns: We report a case of a 57-year-old woman diagnosed with Hansen disease 10 years ago, who suffered from joints swelling, pain and joints deformities of both hands for 19 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000011590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086502PMC
July 2018
1 Read

Peripheral nerve abnormality in HIV leprosy patients.

PLoS Negl Trop Dis 2018 07 18;12(7):e0006633. Epub 2018 Jul 18.

Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil.

Background: The geographical overlap of HIV (human immunodeficiency virus) and leprosy infection has become increasingly frequent and worrying, bringing many clinical issues. Peripheral neuropathy is very frequent in leprosy because of the predilection of its etiologic agent by Schwann cells of the peripheral nervous system, and it also affects individuals with HIV as one of the most common neurological manifestations.

Methodology/principal Findings: The present study compared a cohort of 63 patients diagnosed with leprosy and coinfected with HIV with a cohort of 64 patients with leprosy alone, who were followed at the outpatient clinic of the Nucleus of Tropical Medicine of the Federal University of Pará, Brazil. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066254PMC
July 2018
6 Reads

Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy.

PLoS Negl Trop Dis 2018 07 2;12(7):e0006610. Epub 2018 Jul 2.

Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, England.

Objectives: Neuropathic pain (NP) can occur as a chronic complication of leprosy neuropathy. NP epidemiology and its impact on patients have not been well documented. This study investigates NP prevalence and impact in the years after patients are declared "released from treatment" (RFT) following multidrug therapy (MDT) completion. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044550PMC
July 2018
4 Reads

Correlates of immune exacerbations in leprosy.

Authors:
Annemieke Geluk

Semin Immunol 2018 10 24;39:111-118. Epub 2018 Jun 24.

Dept. of Infectious Diseases, LUMC, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

Leprosy is still a considerable health threat in pockets of several low and middle income countries worldwide where intense transmission is witnessed, and often results in irreversible disabilities and deformities due to delayed- or misdiagnosis. Early detection of leprosy represents a substantial hurdle in present-day leprosy health care. The dearth of timely diagnosis has, however, particularly severe consequences in the case of inflammatory episodes, designated leprosy reactions, which represent the major cause of leprosy-associated irreversible neuropathy. Read More

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http://dx.doi.org/10.1016/j.smim.2018.06.003DOI Listing
October 2018
21 Reads

Footwear in the causation and prevention of foot ulcers in diabetes mellitus.

Natl Med J India 2017 Sep-Oct;30(5):255-261

Schieffelin Leprosy Research and Training Centre, Karigiri 632106, Tamil Nadu, India.

Background.: Inappropriate footwear may be a major cause of foot ulceration among patients with diabetic neuropathy in India. No study has specifically examined the types of footwear or its components in patients with diabetes mellitus and their role in causing foot ulcers. Read More

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http://dx.doi.org/10.4103/0970-258X.234391DOI Listing
December 2018
4 Reads

Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy.

Front Immunol 2018 4;9:1223. Epub 2018 Jun 4.

Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Leprosy reactions are responsible for incapacities in leprosy and represent the major cause of permanent neuropathy. The identification of biomarkers able to identify patients more prone to develop reaction could contribute to adequate clinical management and the prevention of disability. Reversal reaction may occur in unstable borderline patients and also in lepromatous patients. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994478PMC
June 2018
6 Reads

Anti-Lipoarabinomannan-Specific Salivary IgA as Prognostic Marker for Leprosy Reactions in Patients and Cellular Immunity in Contacts.

Front Immunol 2018 30;9:1205. Epub 2018 May 30.

Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Leprosy causes the most common peripheral neuropathy of infectious etiology, posing an important public health problem worldwide. Understanding the molecular and immunological mechanisms of nerve damage induced by is mandatory to develop tools for early diagnosis and preventive measures. The phenolic glycolipid 1 (PGL-1) and lipoarabinomannan (LAM) antigens are major components of the bacterial surface and are implicated on leprosy immunopathogenesis and neural damage. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990868PMC

Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil.

Sci Rep 2018 Jun 8;8(1):8783. Epub 2018 Jun 8.

Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Leprosy is a chronic infectious peripheral neuropathy that is caused by Mycobacterium leprae, and the skin is one of its preferred target sites. However, the effects of this infection on the skin microbiome remain largely unexplored. Here, we characterize and compare the lesional and non-lesional skin microbiomes of leprosy patients and healthy individuals through the deep sequencing of 16 S rRNA genes. Read More

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http://dx.doi.org/10.1038/s41598-018-27074-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993821PMC
June 2018
6 Reads

Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update.

Front Immunol 2018 7;9:939. Epub 2018 May 7.

Center of Health and Biological Sciences, State University of Para, Belem, Brazil.

Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949531PMC
May 2018
4 Reads

Molecular, immunological and neurophysiological evaluations for early diagnosis of neural impairment in seropositive leprosy household contacts.

PLoS Negl Trop Dis 2018 05 21;12(5):e0006494. Epub 2018 May 21.

National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, School of Medicine, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.

Background: Household contacts constitute the highest risk group for leprosy development, and despite significant progress in the disease control, early diagnosis remains the primary goals for leprosy management programs.

Methods: We have recruited 175 seropositive and 35 seronegative household contacts from 2014 to 2016, who were subjected to an extensive protocol that included clinical, molecular (peripheral blood qPCR, slit-skin smear qPCR, skin biopsy qPCR) and electroneuromyographic evaluations.

Results/principal Findings: The positivity of peripheral blood qPCR of seropositive contacts was 40. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983863PMC
May 2018
17 Reads

Neuropathic pain in leprosy: symptom profile characterization and comparison with neuropathic pain of other etiologies.

Pain Rep 2018 Mar 23;3(2):e638. Epub 2018 Feb 23.

Neurology Departament, Pain Center, University of Sao Paulo, Brazil.

Introduction: Previous studies reported a high prevalence of neuropathic pain in leprosy, being especially present in "pharmacologically cured" patients. The presence of neuropathic pain in leprosy poses a supplementary burden in patient's quality of life, daily activities, and mood.

Objectives: The aim of this study was to assess whether neuropathic pain in leprosy has similar symptom profile as neuropathic pain of other etiologies and to retrospectively assess the efficacy of neuropathic pain medications regularly prescribed to leprosy. Read More

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http://dx.doi.org/10.1097/PR9.0000000000000638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902246PMC
March 2018
8 Reads

Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study.

J Peripher Nerv Syst 2018 Jun 7;23(2):120-123. Epub 2018 May 7.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Chronic polyneuropathy is a disabling condition of the peripheral nerves, characterized by symmetrical sensory motor symptoms and signs. There is paucity of studies on the etiological spectrum of polyneuropathy and its impact on quality of life (QoL). The present cross-sectional study in a referral based tertiary care center in North India found diabetic neuropathy as the commonest cause (25. Read More

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http://dx.doi.org/10.1111/jns.12269DOI Listing
June 2018
4 Reads

Genetic variants, structural, and functional changes of Myelin Protein Zero and Mannose-Binding Lectin 2 protein involved in immune response and its allelic transmission in families of patients with leprosy in Colombia.

Infect Genet Evol 2018 07 5;61:215-223. Epub 2018 Apr 5.

Colombian Institute of Tropical Medicine (ICMT), CES University, Cra. 43 A # 52 Sur 99, Sabaneta, Antioquia, Colombia; School of Medicine, CES University, Cl. 10 #22 - 04, Medellín, Antioquia, Colombia; Graduate School, CES University, Cl. 10 #22 - 04, Medellín, Antioquia, Colombia. Electronic address:

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Genetic factors associated with immune response contribute to infection development and disease. M. Read More

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http://dx.doi.org/10.1016/j.meegid.2018.04.002DOI Listing
July 2018
5 Reads

Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain.

Am J Trop Med Hyg 2018 Jun 29;98(6):1609-1613. Epub 2018 Mar 29.

Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Brazil.

Neural pain is a frequent symptom in leprosy disease. There is a paucity of data regarding neural pain diagnostics resulting in common prescriptive errors when neuritis is confused with neuropathic or mixed nociceptive-neuropathic pain. The present study identified important demographic, clinical, and neurophysiological features of 42 leprosy neuropathy patients presenting neuropathic pain (NP). Read More

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http://dx.doi.org/10.4269/ajtmh.17-0817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086157PMC
June 2018
5 Reads

Cutaneous manifestations of diabetic peripheral neuropathy.

Dermatoendocrinol 2017 6;9(1):e1395537. Epub 2017 Dec 6.

Department of Dermatology, Venereology and Leprosy, Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamilnadu, India.

There is a rise in number of people diagnosed with Diabetes Mellitus. The incidence is rising in modern Indian society because of Industrial development and drastically changing lifestyles. Diabetic neuropathies are microvascular disorders that are usually associated with the duration of Diabetes. Read More

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http://dx.doi.org/10.1080/19381980.2017.1395537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821163PMC
December 2017
5 Reads

Association between the Rosén and Lundborg Score and the Screening Activity Limitation and Safety Awareness scale in hand functional evaluation of patients with leprosy diagnosis.

Disabil Rehabil 2018 Jan 30:1-6. Epub 2018 Jan 30.

b Department of Applied Physical Therapy , Federal University of Triângulo Mineiro , Uberaba , Brazil.

Purpose: To evaluate the association of results from the Rosén and Lundborg Score and the screening activity limitation and Safety Awareness scale for the assessment of hand in patients diagnosed with leprosy.

Method: An association between the Rosén and Lundborg Score and the Screening Activity Limitation and Safety Awareness scale for hand was evaluated in a cross-section study with 25 people of a mean age of 51 years old (SD 14), undergoing drug treatment for leprosy.

Results: The mean quantitative score in the Screening Activity Limitation and Safety Awareness scale was 27. Read More

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http://dx.doi.org/10.1080/09638288.2018.1432708DOI Listing
January 2018
4 Reads

Sensory improvement of leprosy peripheral neuropathy in patients treated with perineural injection of platelet-rich plasma.

Int J Dermatol 2018 04 22;57(4):491-492. Epub 2018 Jan 22.

Dermatology, Amala Institute of Medical Sciences, Thrissur, India.

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http://dx.doi.org/10.1111/ijd.13914DOI Listing
April 2018
9 Reads

Revisiting primary neural leprosy: Clinical, serological, molecular, and neurophysiological aspects.

PLoS Negl Trop Dis 2017 Nov 27;11(11):e0006086. Epub 2017 Nov 27.

National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, School of Medicine, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.

Background: Leprosy neuropathy is considered the most common peripheral neuropathy of infectious etiology worldwide, representing a public health problem. Clinical diagnosis of primary neural leprosy (PNL) is challenging, since no skin lesions are found and the slit skin smear bacilloscopy is negative. However, there are still controversial concepts regarding the primary-neural versus pure-neural leprosy definition, which will be explored by using multiple clinical-laboratory analyses in this study. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720806PMC
November 2017
31 Reads

Peripheral Nerve Stimulation for Painful Mononeuropathy Secondary to Leprosy: A 12-Month Follow-Up Study.

Neuromodulation 2018 Apr 29;21(3):310-316. Epub 2017 Oct 29.

Department of Endocrinology, University Hospital of Brasília, Brasilia, Brazil.

Objective: Leprosy affects approximately 10-15 million patients worldwide and remains a relevant public health issue. Chronic pain secondary to leprosy is a primary cause of morbidity, and its treatment remains a challenge. We evaluated the feasibility and safety of peripheral nerve stimulation (PNS) for painful mononeuropathy secondary to leprosy that is refractory to pharmacological therapy and surgical intervention (decompression). Read More

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http://dx.doi.org/10.1111/ner.12714DOI Listing
April 2018
1 Read

Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas.

Emerg Infect Dis 2017 11;23(11):1864-1866

We report Mycobacterium lepromatosis infection in a US-born person with an extensive international travel history. Clinical symptoms, histopathology, and management are similar to those of infections caused by M. leprae. Read More

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http://dx.doi.org/10.3201/eid2311.171104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652441PMC
November 2017
5 Reads

Diseases of the peripheral nerves.

Handb Clin Neurol 2017 ;145:453-474

Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system. Read More

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http://dx.doi.org/10.1016/B978-0-12-802395-2.00031-6DOI Listing
January 2018
16 Reads

Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial.

PLoS Negl Trop Dis 2017 Oct 4;11(10):e0005952. Epub 2017 Oct 4.

Dept. of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: While prednisolone is commonly used to treat recent nerve function impairment (NFI) in leprosy patients, the optimal treatment duration has not yet been established. In this "Treatment of Early Neuropathy in Leprosy" (TENLEP) trial, we evaluated whether a 32-week prednisolone course is more effective than a 20-week course in restoring and improving nerve function.

Methods: In this multi-centre, triple-blind, randomized controlled trial, leprosy patients who had recently developed clinical NFI (<6 months) were allocated to a prednisolone treatment regimen of either 20 weeks or 32 weeks. Read More

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https://dx.plos.org/10.1371/journal.pntd.0005952
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0005952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643133PMC
October 2017
24 Reads

Evaluation of polymerase chain reaction in nerve biopsy specimens of patients with Hansen's disease.

J Neurol Sci 2017 Sep 27;380:187-190. Epub 2017 Jul 27.

Department of Neurology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India. Electronic address:

Background: Pure neuritic variety of leprosy (PNL) presents as peripheral neuropathy with absent skin lesions and negative skin smears. Diagnosing PNL is an uphill task as most of these patients have nonspecific changes on nerve biopsy. In such circumstances, additional molecular diagnostic tools like polymerase chain reaction (PCR) has proven to be useful in diagnosing leprosy. Read More

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http://dx.doi.org/10.1016/j.jns.2017.07.038DOI Listing
September 2017
8 Reads
2.474 Impact Factor

Early detection of neuropathy in leprosy: a comparison of five tests for field settings.

Infect Dis Poverty 2017 Sep 1;6(1):115. Epub 2017 Sep 1.

Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.

Background: Early detection and treatment of neuropathy in leprosy is important to prevent disabilities. A recent study showed that the Nerve Conduction Studies (NCS) and Warm Detection Thresholds (WDT) tests can detect leprosy neuropathy the earliest. These two tests are not practical under field conditions, however, because they require climate-controlled rooms and highly trained staff and are expensive. Read More

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http://dx.doi.org/10.1186/s40249-017-0330-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580225PMC
September 2017
6 Reads

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Cell 2017 Aug;170(5):973-985.e10

Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Immunology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; MRC Laboratory of Molecular Biology, Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 OQH, UK. Electronic address:

Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their subsequent infection. Read More

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http://dx.doi.org/10.1016/j.cell.2017.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848073PMC
August 2017
34 Reads

Extensive sonographic ulnar nerve enlargement above the medial epicondyle is a characteristic sign in Hansen's neuropathy.

PLoS Negl Trop Dis 2017 Jul 28;11(7):e0005766. Epub 2017 Jul 28.

Department of Neurology and Clinical Neurophysiology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.

Objective: Earlier studies have shown sonographic enlargement of the ulnar nerve in patients with Hansen's neuropathy. The present study was performed to determine whether sonography or electrophysiological studies can detect the specific site of ulnar nerve pathology in leprosy.

Methods: Eighteen patients (thirty arms) with Hansen's disease and an ulnar neuropathy of whom 66% had borderline tuberculoid (BT), 27% lepromatous leprosy (LL) and 7% mid-borderline (BB) leprosy were included in the study. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549994PMC
July 2017
14 Reads

Infectious diseases causing autonomic dysfunction.

Clin Auton Res 2018 02 20;28(1):67-81. Epub 2017 Jul 20.

Neurology Department, Raigmore Hospital, Inverness, UK.

Objectives: To review infectious diseases that may cause autonomic dysfunction.

Methods: Review of published papers indexed in medline/embase.

Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

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http://link.springer.com/10.1007/s10286-017-0452-4
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http://dx.doi.org/10.1007/s10286-017-0452-4DOI Listing
February 2018
55 Reads

Multidrug therapy for leprosy: a game changer on the path to elimination.

Lancet Infect Dis 2017 09 7;17(9):e293-e297. Epub 2017 Jul 7.

Instituto Lauro de Souza Lima, Bauru, Brazil.

Leprosy is present in more than 100 countries, where it remains a major cause of peripheral neuropathy and disability. Attempts to eliminate the disease have faced various obstacles, including characteristics of the causative bacillus Mycobacterium leprae: the long incubation period, limited knowledge about its mode of transmission, and its poor growth on culture media. Fortunately, the leprosy bacillus is sensitive to several antibiotics. Read More

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http://dx.doi.org/10.1016/S1473-3099(17)30418-8DOI Listing
September 2017
4 Reads

Anticeramide antibody and butyrylcholinesterase in peripheral neuropathies.

J Clin Neurosci 2017 Aug 30;42:204-208. Epub 2017 May 30.

Nireekshana-ACET/CODEWEL, Hyderabad, Telangana 500029, India. Electronic address:

Ceramide is a glycosphingolipid, a component of nerve and non neuronal cell membrane and plays a role in maintaining the integrity of neuronal tissue. Butyrylcholinesterase (BChE) is a multifunctional enzyme, its involvement in neurodegenerative diseases has been well established. Anticeramide antibody (Ab-Cer) and enzyme BChE have been implicated in peripheral neuropathies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868163073
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http://dx.doi.org/10.1016/j.jocn.2017.04.023DOI Listing
August 2017
17 Reads

Is Ross Syndrome an Autoimmune Entity? A Case Series of 11 Patients.

Can J Neurol Sci 2017 May;44(3):318-321

3Department of Neurology,Christian Medical College,Vellore,Tamil Nadu,India.

Background: Ross syndrome is diagnosed by the presence of segmental anhidrosis, areflexia, and tonic pupils. Fewer than 60 cases have been described in literature so far. There have been reports of presence of antibodies in such patients, suggesting an autoimmune pathogenesis. Read More

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http://dx.doi.org/10.1017/cjn.2016.417DOI Listing
May 2017
27 Reads
1.600 Impact Factor

An Employee With Undiagnosed Leprosy: Are Other Employees at Risk?

Authors:
Ann R Lurati

Workplace Health Saf 2017 Jul 9;65(7):284-286. Epub 2017 May 9.

1 California State University, Monterey Bay.

MJ is a janitor working in an office building for the past 5 years. He sustained a third-degree burn with a secondary infection and was sent to the county hospital. He was diagnosed with leprosy. Read More

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http://dx.doi.org/10.1177/2165079917697994DOI Listing
July 2017
18 Reads

Ultrasound elastography assessment of the median nerve in leprosy patients.

Muscle Nerve 2017 09 4;56(3):393-398. Epub 2017 Mar 4.

Physics Department, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, University of São Paulo, Brazil.

Introduction: We sought to compare median nerve elasticity between leprosy patients (LPs) and healthy volunteers (HVs) using ultrasound elastography (UE).

Methods: Two radiologists independently measured the strain ratio of the median nerve/flexor digitorum superficialis muscle (MN/FDSM) of 18 LP and 18 HV using real-time freehand UE. Statistical analysis included intra-class correlation coefficients (ICC) and Mann-Whitney test. Read More

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http://dx.doi.org/10.1002/mus.25510DOI Listing
September 2017
29 Reads

A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy.

Nat Commun 2016 12 15;7:13760. Epub 2016 Dec 15.

Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong 250000, China.

Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. Read More

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http://dx.doi.org/10.1038/ncomms13760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172377PMC
December 2016
42 Reads

Leprosy in a patient infected with HIV.

Pract Neurol 2017 Apr 9;17(2):135-139. Epub 2016 Dec 9.

St George's University Hospitals, London, UK.

A 60-year-old Nigerian man, who had lived in Europe for 30 years but had returned home frequently, presented with right frontalis muscle weakness and right ulnar nerve palsy, without skin lesions. Neurophysiology showed a generalised neuropathy with demyelinating features. Blood tests were positive for HIV, with a normal CD4 count. Read More

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http://dx.doi.org/10.1136/practneurol-2016-001519DOI Listing
April 2017
34 Reads

Protocol for a Randomised Controlled Trial Investigating Decompression for Leprous Neuropathy (The DELN Protocol).

Lepr Rev 2016 Dec;87(4):553-61

Objectives: An expert group of peripheral nerve surgeons, reconstructive surgeons, and immunologists who have extensive experience with Hansen’s Disease convened to discuss the status of nerve decompression as a treatment for leprous neuropathy. The expert group recommended an international, multi-center randomised controlled trial (RCT). Subsequently, a study protocol called Decompression for Leprous Neuropathy (DELN) was designed and further refined by multiple investigators worldwide. Read More

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December 2016
3 Reads

High resolution sonographic examination: a newer technique to study ulnar nerve neuropathy in leprosy.

Lepr Rev 2016 Dec;87(4):464-75

Objectives: A prospective case control study was conducted to calculate normal dimensions of ulnar nerve and study the size, echotexture and morphologic alterations in ulnar nerve in patients with leprosy.

Methods: The study group included 48 patients diagnosed with leprosy on basis of clinical, bacteriologic and/or histopathologic evaluation. Sonographic measurements were taken at 3 levels around elbow. Read More

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December 2016

Ultrasonography of Leprosy Neuropathy: A Longitudinal Prospective Study.

PLoS Negl Trop Dis 2016 11 16;10(11):e0005111. Epub 2016 Nov 16.

Radiology Division, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo Ribeirão Preto, São Paulo, Brazil.

Background: Previous studies have shown that leprosy multi-drug therapy (MDT) does not stop the progression of nerve function impairment. There are no prospective studies investigating the evolution of nerve anatomic abnormalities after treatment. We examined leprosy patients aiming to investigate the evolution of nerve ultrasonography (US) abnormalities and the risk factors for poor outcomes after MDT. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112942PMC
November 2016
3 Reads