580 results match your criteria Leprosy Neuropathy of


A review of nutrition in neuropathic pain of leprosy.

Ther Adv Infect Dis 2022 Jan-Dec;9:20499361221102663. Epub 2022 Jun 1.

Tropical Disease Unit, Toronto General Hospital, 200 Elizabeth Street, 13EN-218, Toronto, ON M5G 2C4, Canada.

Leprosy is a neglected tropical disease (NTD) that continues to burden low- and middle-income countries (LMICs), despite being eliminated as a public health concern by the World Health Organization (WHO) in 2000. The causative agents, and , affect nearly 200,000 individuals globally each year, with over 19,000 new cases detected in the Americas in 2020 alone. Canada has experienced an increasing incidence of leprosy, due to rising levels of travel and migration from endemic areas, reaching over 37,000 individuals with leprosy by the end of 2020. Read More

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Ulnar Artery Perforator Adiposal Flap for Paraffinoma Treatment in a Patient With Leprosy: A Case Report.

J Hand Surg Glob Online 2022 May 10;4(3):172-175. Epub 2021 Dec 10.

Department of Orthopaedic Surgery, Yodogawa Christian Hospital, Kunijima, Higashiyodogawa-ku, Osaka, Japan.

Leprosy is a chronic infection in humans that mainly affects the peripheral nerves and skin. Paraffin filling has been previously used for muscle atrophy treatment. However, the formation of paraffin granulomas (paraffinomas) can occur over the long term. Read More

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A Young Female With Borderline Lepromatous Leprosy and Tuberculous Lymphadenitis: A Rare Coinfection.

Cureus 2022 Apr 6;14(4):e23892. Epub 2022 Apr 6.

Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.

In Bangladesh, tuberculosis and leprosy are endemic mycobacterial diseases; however, co-infection is rarely seen. Our patient had a high-grade fever, symmetrical polyarthritis, polymorphous erythematous lesions, widespread lymphadenopathy, peripheral neuropathy, bilaterally thickened ulnar nerves, and claw hands. A lymph node biopsy revealed tuberculosis having acid-fast bacilli with caseating epithelioid histiocytic granuloma. Read More

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Gene Expression Profile of Contribution in the Pathology of Leprosy Neuropathy.

Front Med (Lausanne) 2022 15;9:861586. Epub 2022 Apr 15.

Laboratory of Cell Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Peripheral neuropathy is the main cause of physical disability in leprosy patients. Importantly, the extension and pattern of peripheral damage has been linked to how the host cell will respond against () infection, in particular, how the pathogen will establish infection in Schwann cells. Interestingly, viable and dead have been linked to neuropathology of leprosy by distinct mechanisms. Read More

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Ultrasonography as a diagnostic tool for Neural Pain in Leprosy.

PLoS Negl Trop Dis 2022 04 29;16(4):e0010393. Epub 2022 Apr 29.

Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.

Leprosy is still a prevalent disease in Brazil, representing 93% of all occurrences in the Americas. Leprosy neuropathy is one of the most worrying manifestations of the disease. Acute neuropathy usually occurs during reaction episodes and is called neuritis. Read More

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Circulation, sensation, and hair growth: A reply.

J Am Acad Dermatol 2022 Apr 25. Epub 2022 Apr 25.

Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

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Mycobacterium leprae induces Schwann cell proliferation and migration in a denervated milieu following intracutaneous excision axotomy in nine-banded armadillos.

Exp Neurol 2022 06 24;352:114053. Epub 2022 Mar 24.

Neurology, Johns Hopkins University, Baltimore, MD, USA.

Nine-banded armadillos develop peripheral neuropathy after experimental Mycobacterium leprae infection that recapitulates human disease. We used an intracutaneous excision axotomy model to assess the effect of infection duration by M. leprae on axonal sprouting and Schwan cell density. Read More

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Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19.

Front Cell Infect Microbiol 2022 24;12:815738. Epub 2022 Feb 24.

Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. Read More

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Follow-up assessment of patients with Pure Neural Leprosy in a reference center in Rio de Janeiro-Brazil.

PLoS Negl Trop Dis 2022 01 11;16(1):e0010070. Epub 2022 Jan 11.

Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.

Introduction: Pure Neural Leprosy (PNL) is a rare clinical form of leprosy in which patients do not present with the classical skin lesions but have a high burden of the disability associated with the disease. Clinical characteristics and follow up of patients in PNL are still poorly described in the literature.

Objective: This paper aims to describe the clinical, electrophysiological and histopathological characteristics of PNL patients, as well as their evolution after multidrug therapy (MDT). Read More

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January 2022

Platelet-Rich Plasma: A Comprehensive Review of Emerging Applications in Medical and Aesthetic Dermatology.

J Clin Aesthet Dermatol 2021 Nov;14(11):44-57

Dr. White is with Dermatology Partners in Strongsville, Ohio.

Platelet-rich plasma (PRP) has been integrated into numerous treatment regimens for medical and aesthetic dermatology. While some of these approaches are well-established, many uses are underreported in the literature. We sought to identify and summarize the emerging dermatologic applications for PRP by conducting a comprehensive PubMed search of studies published between 2000 and 2020. Read More

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November 2021

Lepra reactions: A study of 130 cases from Pakistan.

J Pak Med Assoc 2021 Oct;71(10):2317-2320

Marie Adelaide Leprosy Centre MALC, Karachi, Pakistan.

Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients.

Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Read More

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October 2021

Clinical and electrophysiological characteristics of neuropathic pain in leprosy patients: A prospective cross-sectional study.

Indian J Dermatol Venereol Leprol 2021 Oct 20:1-4. Epub 2021 Oct 20.

Department of Dermatology, Federal University of Para, Belém, Pará, Brazil.

Introduction: Neuropathic pain is a common and disabling late complication of leprosy. We investigated the clinical and electrophysiological characteristics of neuropathic pain in leprosy patients by evaluating nerve conduction, sympathetic skin response (SSR) and A-waves.

Methods: Twenty one leprosy patients with neuropathic pain validated by the Douleur Neuropathique en 4 (DN4)Questionnaire were selected for study. Read More

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October 2021

Efficacy of Autologous Smashed Follicular Dermal Graft and Epidermal Cell Suspension in the Treatment of Chronic Nonhealing Trophic Ulcers in Hansen's Patients.

Indian Dermatol Online J 2021 Nov-Dec;12(6):868-872. Epub 2021 Nov 22.

Department of Dermatology, Venereology and Leprosy, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.

Context: Plantar ulcers occur in patients with leprosy not because of the disease but because of its neuropathic effects on the skin on the feet. Neuropathy increases the risk of trauma to patients' feet, leading to the development of ulcers. With the introduction of new therapeutic regimens, leprosy can now be cured. Read More

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November 2021

Bilateral ptosis/blepharitis due to lepromatous leprosy.

Am J Ophthalmol Case Rep 2022 Mar 30;25:101236. Epub 2021 Nov 30.

Department of Ophthalmology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA.

Purpose: To underscore the importance of histopathological evaluation in cases presenting with a constellation of unusual ocular inflammation and physical findings.

Observation: A 51-year-old male, presented with a chief complaint of worsening visual field loss due to droopy eyelids two months post excision of a right upper eyelid squamous cell carcinoma. His past medical history included chronic edematous facial features, chronic sinusitis, unexplained peripheral neuropathy, and worsening fatigue. Read More

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Clinical Significance of Non-invasive Skin Autofluorescence Measurement in Patients with Diabetes: A Systematic Review and Meta-analysis.

EClinicalMedicine 2021 Dec 16;42:101194. Epub 2021 Nov 16.

Nivanpharmed Pharmaceutical Company, Tehran, Iran.

Background: Advanced glycation end products (AGE), one of the main factors causing diabetic end-organ damage, accumulate in long half-life proteins, such as skin and cartilage collagen. AGE measurement may offer additional evidence to predict diabetic vascular complications. Skin autofluorescence (SAF) is suggested as a non-invasive, quick, and reliable method to measure tissue AGE level. Read More

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December 2021

Intraneural ganglion cyst of the ulnar nerve causing cubital tunnel syndrome masquerading a peripheral nerve abscess of a neuritic leprosy.

J Clin Orthop Trauma 2022 Jan 11;24:101692. Epub 2021 Nov 11.

Jubilee Mission Medical College and Research Center, Thrissur, Kerala, India.

Cubital tunnel syndrome is a common entrapment neuropathy affecting the ulnar nerve. Intraneural ganglion cyst and nerve abscess due to leprosy can cause cubital tunnel syndrome. In this article, we are presenting a case of cubital tunnel syndrome caused due to an intraneural ganglion cyst in a 48-year-old lady. Read More

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January 2022

Treatment and Evaluation Advances in Leprosy Neuropathy.

Neurotherapeutics 2021 10 19;18(4):2337-2350. Epub 2021 Nov 19.

National Hansen's Disease Programs, Baton Rouge, LA, 70816, USA.

Neuropathy and related disabilities are the major medical consequences of leprosy, which remains a global medical concern. Despite major advances in understanding the mechanisms of M. leprae entry into peripheral nerves, most aspects of the pathogenesis of leprosy neuropathy remain poorly understood. Read More

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October 2021

The red flags of ulnar neuropathy in leprosy.

PLoS One 2021 19;16(11):e0259804. Epub 2021 Nov 19.

Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.

The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in the differential diagnosis of ulnar neuropathy (UN) in leprosy and that of non-leprosy etiology. In addition, we include putative markers to better understand the inflammatory process that may occur in the nerve. Read More

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January 2022

Parsonage-Turner syndrome: a firsthand experience of an uncommon malady.

Am J Neurodegener Dis 2021 15;10(4):34-37. Epub 2021 Aug 15.

Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Government Medical College Kangra (Tanda) 176001, Himachal Pradesh, India.

Parsonage Turner Syndrome (syn. idiopathic brachial plexopathy, neurologic amyotrophy) is a rare syndrome of poorly understood etiology with a reported incidence of 1.64 in 1 lakh persons per year. Read More

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Primary neural leprosy: clinical, neurophysiological and pathological presentation and progression.

Brain 2022 05;145(4):1499-1506

Division of Neuromuscular Disorders, Department of Neurology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto 14048-900, Brazil.

Disability in leprosy is a direct consequence of damage to the peripheral nervous system which is usually worse in patients with no skin manifestations, an underdiagnosed subtype of leprosy known as primary neural leprosy. We evaluated clinical, neurophysiological and laboratory findings of 164 patients with definite and probable primary neural leprosy diagnoses. To better understand the disease progression and to improve primary neural leprosy clinical recognition we compared the characteristics of patients with short (≤12 months) and long (>12 months) disease duration. Read More

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Role of diffusion tensor imaging in the evaluation of ulnar nerve involvement in leprosy.

Br J Radiol 2022 Jan 24;95(1129):20210290. Epub 2021 Sep 24.

Department of Radiology, AIIMS, New Delhi, India.

Objective: Early detection of peripheral neuropathy is extremely important as leprosy is one of the treatable causes of peripheral neuropathy. The study was undertaken to assess the role of diffusion tensor imaging (DTI) in ulnar neuropathy in leprosy patients.

Methods: This was a case-control study including 38 patients (72 nerves) and 5 controls (10 nerves) done between January 2017 and June 2019. Read More

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January 2022

Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study.

PLoS Negl Trop Dis 2021 09 23;15(9):e0009794. Epub 2021 Sep 23.

National Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Federal University of Uberlandia, Uberlândia, Brazil.

Background: Neuropathic pain (NP) is one of the main complications of leprosy, and its management is challenging. Infrared thermography (IRT) has been shown to be effective in the evaluation of peripheral autonomic function resulting from microcirculation flow changes in painful syndromes. This study used IRT to map the skin temperature on the hands and feet of leprosy patients with NP. Read More

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September 2021

Polyarthritis, neuropathy, and persistent violaceous plaques.

JAAD Case Rep 2021 Sep 1;15:97-99. Epub 2021 Feb 1.

Department of Pathology and Laboratory Medicine, University of California, Davis, California.

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September 2021

Clinical prediction rules for the diagnosis of neuritis in leprosy.

BMC Infect Dis 2021 Aug 23;21(1):858. Epub 2021 Aug 23.

Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil.

Background: Diagnosing neuritis in leprosy patients with neuropathic pain or chronic neuropathy remains challenging since no specific laboratory or neurophysiological marker is available.

Methods: In a cross-sectional study developed at a leprosy outpatient clinic in Rio de Janeiro, RJ, Brazil, 54 individuals complaining of neural pain (single or multiple sites) were classified into two groups ("neuropathic pain" or "neuritis") by a neurological specialist in leprosy based on anamnesis together with clinical and electrophysiological examinations. A neurologist, blind to the pain diagnoses, interviewed and examined the participants using a standardized form that included clinical predictors, pain features, and neurological symptoms. Read More

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Leprous Neuropathy: Observational Study Highlighting the Role of Electrophysiology in Early Diagnosis.

J Neurosci Rural Pract 2021 Jul 16;12(3):530-534. Epub 2021 Jun 16.

Kerala University of Health Sciences, Thrissur, Kerala, India.

 Worldwide leprosy is a common cause of peripheral neuropathy. Electrophysiology is underutilized in its diagnosis.  This study aims to evaluate the usefulness of electrophysiological study in the diagnosis of leprous neuropathy. Read More

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Pure neural leprosy or amyloid neuropathy? Systematic review and clinical case report.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):140-149

Universidade Federal de Alagoas, Medical Degree - Arapiraca (AL), Brasil.

Objective: To review the literature and to report a clinical case with initial suspicion of pure neural leprosy and final diagnosis of amyloid neuropathy.

Methods: The study was conducted in two stages. In stage one, a systematic literature review was carried out, with searches performed in the PubMed, Medline, and Lilacs databases, as well as in the leprosy sectoral library of the Virtual Health Library, using the following descriptors: neuritic leprosy, pure neural leprosy, primary neural leprosy, pure neuritic leprosy, amyloid polyneuropathy, amyloid neuropathies, and amyloid polyneuropathy. Read More

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January 2021

Common late complications of longitudinal forefoot amputations in neuropathic foot treatment.

J Wound Care 2021 Jun;30(6):498-503

Department of Orthopedics and Traumatology, Hospital das Clínicas HCFMUSP, Faculty of Medicine, University of São Paulo, Brazil.

Objective: To describe and quantify the complications arising in consecutive neuropathic patients undergoing partial longitudinal amputations of the foot.

Method: A retrospective study was conducted with data collected from the medical records of patients monitored at the Insensitive Foot Clinic of the Foot and Ankle Group of our institution who underwent partial amputation of foot rays from 2000 to 2016.

Results: A total of 28 patients met the inclusion criteria, with a total of 31 amputated/partially amputated feet. Read More

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Clinical evolution of neural function in a series of leprosy neuropathy cases after ulnar neurolysis.

An Bras Dermatol 2021 Jul-Aug;96(4):500-502. Epub 2021 Jun 5.

Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

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Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of .

Front Mol Biosci 2021 7;8:663301. Epub 2021 May 7.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

Leprosy, caused by , is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties, respectively, and control the dissemination of infection in the host. However, the current treatment is not cost-effective, does not favor patient compliance due to its long duration (12 months) and does not protect against the incumbent nerve damage, which is a severe leprosy complication. Read More

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