554 results match your criteria Leprosy Neuropathy of

Pure neural leprosy or amyloid neuropathy? Systematic review and clinical case report.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):140-149

Universidade Federal de Alagoas, Medical Degree - Arapiraca (AL), Brasil.

Objective: To review the literature and to report a clinical case with initial suspicion of pure neural leprosy and final diagnosis of amyloid neuropathy.

Methods: The study was conducted in two stages. In stage one, a systematic literature review was carried out, with searches performed in the PubMed, Medline, and Lilacs databases, as well as in the leprosy sectoral library of the Virtual Health Library, using the following descriptors: neuritic leprosy, pure neural leprosy, primary neural leprosy, pure neuritic leprosy, amyloid polyneuropathy, amyloid neuropathies, and amyloid polyneuropathy. Read More

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January 2021

Common late complications of longitudinal forefoot amputations in neuropathic foot treatment.

J Wound Care 2021 Jun;30(6):498-503

Department of Orthopedics and Traumatology, Hospital das Clínicas HCFMUSP, Faculty of Medicine, University of São Paulo, Brazil.

Objective: To describe and quantify the complications arising in consecutive neuropathic patients undergoing partial longitudinal amputations of the foot.

Method: A retrospective study was conducted with data collected from the medical records of patients monitored at the Insensitive Foot Clinic of the Foot and Ankle Group of our institution who underwent partial amputation of foot rays from 2000 to 2016.

Results: A total of 28 patients met the inclusion criteria, with a total of 31 amputated/partially amputated feet. Read More

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Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of .

Front Mol Biosci 2021 7;8:663301. Epub 2021 May 7.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

Leprosy, caused by , is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties, respectively, and control the dissemination of infection in the host. However, the current treatment is not cost-effective, does not favor patient compliance due to its long duration (12 months) and does not protect against the incumbent nerve damage, which is a severe leprosy complication. Read More

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Role of shear wave elastography in treatment follow-up of leprosy neuropathy.

J Ultrasound 2021 May 6. Epub 2021 May 6.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Purpose: Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neuropathy. Our purpose was to evaluate the role of shear wave elastography in assessing stiffness changes within the ulnar nerve during treatment of leprosy. Read More

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Sonographic pattern of median nerve enlargement in Hansen's neuropathy.

Acta Neurol Scand 2021 Apr 26. Epub 2021 Apr 26.

Karnataka Medical Research Foundation, Bangalore, India.

Objectives: Median nerve enlargement in leprosy seems to be more proximal than in carpal tunnel syndrome (CTS), but this feature has not been studied systematically. The aim of the study was to compare the sites of median nerve enlargement in patients with leprosy with that of patients with CTS.

Materials And Methods: Transverse sections of the median nerve were recorded from wrist to the mid-forearm (at distal wrist crease and at 2-cm: M1, 4-cm: M2, 6-cm: M3, 8-cm: M4 and 10-cm: M5, proximal to the distal wrist crease in the forearm) in patients with leprosy, CTS and healthy subjects using high-resolution ultrasound. Read More

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Comparison between nerve conduction study and high-resolution ultrasonography with color doppler in type 1 and type 2 leprosy reactions.

Clin Neurophysiol Pract 2021 17;6:97-102. Epub 2021 Mar 17.

Neurophysiology Division, Lauro de Souza Lima Institute, Brazil.

Objective: To analyze the role of high-resolution ultrasonography with color Doppler (HRUS with CD) to diagnose inflammatory activity (IA) in nerves of leprosy patients under type 1 (RT1) and 2 (RT2) reactions compared to Nerve Conduction Studies (NCS).

Methods: Leprosy patients with signs or symptoms suggestive of neuritis (RT1 and RT2) without corticosteroids use were selected. They were evaluated by NCS and subsequently by HRUS with CD. Read More

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Pearls & Oy-sters: "Quiet Nerve Paralysis" due to Symmetrical Neuropathy in Pure Neuritic Leprosy.

Neurology 2021 05 24;96(19):e2451-e2453. Epub 2021 Mar 24.

From the Departments of Pathology (P.S., R.V.) and Neurology (V.K.S., V.K.P.), SGPGIMS, Lucknow, India.

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Death and Rebirth of the Thalidomide Molecule: A Case of Thalidomide-Induced Sensory Neuropathy.

Cureus 2021 Feb 4;13(2):e13140. Epub 2021 Feb 4.

Neurology, Flowers Medical Group, Dothan, USA.

The thalidomide molecule is a remarkable molecule that exists in a racemic mixture of optical isomers. In the 1950s, due to its teratogenicity, the levorotatory isomer led to its dramatic downfall. However, the molecule with its panoramic mechanisms of action and its uncanny ability to intercalate within the geometry of deoxyribonucleic acid (DNA), led to its remarkable renaissance; thalidomide being United States Food and Drug Administration (FDA)-approved for at least 13 different indications ranging from multiple myeloma to leprosy to glioblastoma. Read More

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February 2021

Understanding Demyelination in Leprosy Neuropathy: A Nerve Biopsy Analysis.

Ann Indian Acad Neurol 2020 Nov-Dec;23(6):829-832. Epub 2020 Jun 5.

Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India.

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Sonographic evaluation of leprosy of ulnar nerve.

Radiol Case Rep 2021 May 24;16(5):1057-1060. Epub 2021 Feb 24.

Hamad Medical Corporation, Doha, Qatar.

Leprosy is a chronic granulomatous infection caused by Mycobacterium Leprae that predominantly affects the skin and peripheral nerves. The disease is prevalent in developing countries of Asia and Africa, with occasional cases reported from United States. In this case report we highlight a 33-year-old man from Qatar, who presented with symptoms of progressive weakness in his left wrist and hand for six months and was later found to have a granuloma of the ulnar nerve secondary to leprosy. Read More

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Is Perls Prussian Blue Stain for Hemosiderin a Useful Adjunct in the Diagnosis of Vasculitic Neuropathies?

Neurol India 2021 Jan-Feb;69(1):140-146

Department of Neuropathology, National Institute of Mental Health Neurosciences, Bangalore, Karnataka, India.

Background: Perls Prussian blue stain (PPB) for hemosiderin, a marker of vascular injury is often employed as an adjunct in the diagnosis of vasculitic neuropathies. However, inflammation/vascular injury is also seen in leprosy, immune mediated, paraproteinemic, diabetic neuropathies, etc. The frequency of detection of hemosiderin in these neuropathies and its utility in diagnosis of vasculitis has not been explored. Read More

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Autophagy 2021 Jan 8;17(1):1-382. Epub 2021 Feb 8.

University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Read More

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January 2021

Clinical and pathological features of different types of leprosy.

Eur Rev Med Pharmacol Sci 2021 01;25(2):1050-1059

Department of Dermatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Objective: This study aimed to investigate the clinical and pathological features of leprosy bacillus-related neuropathy in different clinical stages.

Patients And Methods: Four patients confirmed to have leprosy between 2012 and 2020 were chosen as the primary study subjects. The patients' clinical data were retrospectively analyzed to investigate the clinical and pathological features of the different clinical types of leprosy. Read More

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January 2021

Granulomatous interstitial nephritis in granulomatosis with polyangiitis mimicking leprosy: A case report.

J Family Med Prim Care 2020 Nov 30;9(11):5783-5786. Epub 2020 Nov 30.

Department of General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong.

Granulomatous polyangiitis (GPA) is a small vessel vasculitis commonly affecting the upper and lower respiratory tracts and kidneys. About 90% of the cases are associated with ANCA, namely, PR3-ANCA and MPO-ANCA. Herein, we describe a patient of GPA who presented with anasarca, sensory neuropathy, recurrent upper airway congestion, epistaxis, and rapidly progressive glomerulonephritis. Read More

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November 2020

Laser evoked potentials in the evaluation of hypoesthetic patches in tuberculoid leprosy.

Clin Neurophysiol 2021 Feb 9;132(2):542-544. Epub 2020 Dec 9.

Neurophysiology Unit, Neurology Department, Hospital Universitari de Bellvitge, Feixa Llarga, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

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February 2021

The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India.

Ann N Y Acad Sci 2020 Dec 31. Epub 2020 Dec 31.

Department of Obstetrics and Gynecology, Makunda Christian Leprosy and General Hospital, Assam, India.

In this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at-risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies. Read More

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December 2020

Consensus on the diagnosis and management of chronic leg ulcers - Brazilian Society of Dermatology.

An Bras Dermatol 2020 Nov-Dec;95 Suppl 1:1-18. Epub 2020 Oct 4.

Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Background: Chronic leg ulcers affect a large portion of the adult population and cause a significant social and economic impact, related to outpatient and hospital care, absence from work, social security expenses, and reduced quality of life. The correct diagnosis and therapeutic approach are essential for a favorable evolution.

Objective: To gather the experience of Brazilian dermatologists, reviewing the specialized literature to prepare recommendations for the diagnosis and treatment of the main types of chronic leg ulcers. Read More

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December 2020

Neuropathies of leprosy.

J Neurol Sci 2021 01 25;420:117288. Epub 2020 Dec 25.

Foundation for Medical Research, Mumbai, India.

Neuropathies form an integral part of the symptomatology of leprosy. Neuropathies of leprosy take various forms and shapes. At one end is the cutaneous nerve involvement adjacent to the anaesthetic skin patch and the other is of symmetrical pansensory neuropathy and the devastating sensory ataxia of leprous ganglionits. Read More

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January 2021

Morphometric analysis of nerve fibers in neural leprosy.

Muscle Nerve 2021 04 11;63(4):593-599. Epub 2021 Jan 11.

Departament of Neurosciences and Behavioral Sciences, School of Medicine of Ribeirão Preto, University of the State of São Paulo, Ribeirão Preto, Brazil.

Background: The present study assesses the contributions of axonal degeneration and demyelination in leprosy nerve damage. New clinical strategies can emerge from an in-depth understanding of the pathogenesis of neural leprosy (NL).

Methods: Morphometric analysis of myelinated nerve fibers was performed on 44 nerve biopsy samples collected from leprosy patients. Read More

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Nail Changes in Leprosy: Onychoscopy Evaluation.

Indian Dermatol Online J 2020 Nov-Dec;11(6):970-974. Epub 2020 Sep 19.

Department of Social and Preventive Medicine, Government Medical College, Kozhikode, Kerala, India.

Context: Repeated trauma involving extremities (in the setting of peripheral neuropathy) and poor vascularity that impairs wound healing are important causes of disability and deformity in leprosy patients. Nail changes can serve as indicators of trophic changes due to leprosy.

Aims: To describe the onychoscopy findings in leprosy cases and to identify any specific findings in leprosy patients in comparison to controls. Read More

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September 2020

Relationship between Plantar Pressure and Sensory Disturbance in Patients with Hansen's Disease-Preliminary Research and Review of the Literature.

Sensors (Basel) 2020 Dec 6;20(23). Epub 2020 Dec 6.

Department of Dermatology, National Sanatorium Tamazenshoen, Higashi-Murayama, Tokyo 189-0002, Japan.

Orthoses and insoles are among the primary treatments and prevention methods of refractory plantar ulcers in patients with Hansen's disease. While dynamic plantar pressure and tactile sensory disturbance are the critical pathological factors, few studies have investigated whether a relationship exists between these two factors. In this study, dynamic pressure measured using F-scan system and tactile sensory threshold evaluated with monofilament testing were determined for 12 areas of 20 feet in patients with chronic Hansen's disease. Read More

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December 2020

Functional Outcome of Early, Selective Surgical Nerve Decompression in Leprous Neuropathy.

J Hand Surg Asian Pac Vol 2020 Dec;25(4):407-416

Department of Orthopaedic Surgery, Maulana Azad Medical College & Lok Nayak Hospital, New Delhi, India.

Leprous neuropathy is a significant, yet preventable, cause of disability worldwide. Decompressive surgery and oral steroids have been used along with Multi Drug Therapy (MDT) for treating leprous neuropathy with varied success as reported in literature. We prospectively studied 16 peripheral nerves in 10 patients with leprous neuropathy of less than a year duration and not responding to steroid therapy in 3 weeks. Read More

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December 2020

Functional Impairment of Skin Appendages Due to Peripheral Nerve Involvement by .

Open Forum Infect Dis 2020 Oct 12;7(10):ofaa419. Epub 2020 Sep 12.

Leprology-Venereology Service, Muhimbili National Hospital, Dar es Salaam, United Republic of Tanzania.

In the earliest stage of infection, bacteria parasitize fine fiber twigs of autonomic peripheral nerves supplying efferent impulses to appendages of the skin. This obligate intracellular pathogen invades Schwann cells, the glial cells of peripheral nerves. Intracellular events inhibit Schwann cell physiology in complex ways, which include demyelination and dedifferentiation. Read More

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October 2020

Huntington's disease-like 2: a phenocopy not to miss.

Pract Neurol 2020 Dec 29;20(6):479-481. Epub 2020 Sep 29.

Neurology Department, USP Ribeirão Preto, Ribeirão Preto, Brazil.

A 67-year-old Brazilian man of African ancestry and his 60-year-old sister both presented with choreiform movements, although in the man these were significantly overshadowed by additional parkinsonism. The man also had a history of four epileptic seizures. Neurological examination in each also found slow saccades and a dysexecutive syndrome. Read More

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December 2020

Ofloxacin-Containing Multidrug Therapy in Ambulatory Leprosy Patients: A Case Series.

J Cutan Med Surg 2021 Jan-Feb;25(1):45-52. Epub 2020 Sep 1.

Tropical Disease Unit, Toronto General Hospital, Toronto, ON, Canada.

Background: Standard dapsone and clofazimine-containing multidrug therapy (MDT) for leprosy is limited by drug tolerability, which poses treatment adherence barriers. Although ofloxacin-based regimens are promising alternatives, current efficacy and safety data are limited, particularly outside of endemic areas. We evaluated treatment outcomes in patients with leprosy receiving ofloxacin-containing MDT (OMDT) at our center. Read More

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September 2020

Endoneural abscess of common popliteal nerve as first clinical manifestation of leprosy: the first reported case in history in a low-incidence country.

J Prev Med Hyg 2020 Jun 4;61(2):E148-E151. Epub 2020 Jul 4.

Division of Neurosurgery, Department of Neuroscience, Ospedale Policlinico San Martino-IST, University of Genoa, Genoa, Italy.

A migrant from Palestine came to our attention for weakness of dorsiflexion of the left foot and hypoesthesia of the homolateral common peroneal nerve territory. Skin biopsies from skin lesions in the hypoesthetic area were not diagnostic. Radiological investigation showed focal nerve enlargement with a possible focal lesion. Read More

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Leprosy in Refugees and Migrants in Italy and a Literature Review of Cases Reported in Europe between 2009 and 2018.

Microorganisms 2020 Jul 24;8(8). Epub 2020 Jul 24.

Department of Infectious, Tropical Diseases and Microbiology, I.R.C.C.S. Sacro Cuore Don Calabria Hospital, Via Sempreboni 5, 37024 Negrar di Valpolicella, Italy.

Leprosy is a chronic neglected infectious disease that affects over 200,000 people each year and causes disabilities in more than four million people in Asia, Africa, and Latin America. The disease can appear with a wide spectrum of clinical forms, and therefore the clinical suspicion is often difficult. Refugees and migrants from endemic countries affected by leprosy can remain undiagnosed in Europe due to the unpreparedness of clinicians. Read More

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Peripheral nerve biopsy: a tool still needed in the early diagnosis of neural leprosy?

Trans R Soc Trop Med Hyg 2020 11;114(11):792-797

National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberlândia (UFU), 1720 Pará Avenue, Uberlândia, MG, 38400-902, Brazil.

Background: The early recognition of neural impairment in leprosy, especially in primary neural forms, represents a challenge in clinical practice and a peripheral nerve biopsy may be required for diagnostic confirmation. This study aims to characterize the epidemiological, clinical, electroneuromyographic, laboratory and histopathological aspects of patients undergoing peripheral nerve biopsy during investigation of primary neural cases in leprosy.

Methods: A total of 104 patients with peripheral neuropathy who were referred to a national reference centre for leprosy were biopsied from 2014 to 2018. Read More

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November 2020