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    An Innovative Cooling Jacket to Combat Heat Intolerance in Children with Anhidrosis.
    Pediatr Dermatol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Dermatology, Venereology and Leprosy, Sri B.M. Patil Medical College, Hospital and Research Center, BLDE University, Vijayapur, Karnataka, India.
    Hyperthermia and heat intolerance are distressing symptoms in patients with anhidrosis. Body cooling devices are an integral part of management of these patients. A cooling jacket made from easily available materials has been invented for a girl with congenital insensitivity to pain and anhidrosis with severe heat intolerance. Read More

    Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions Th17 Immune Response in Leprosy.
    Scand J Immunol 2017 Apr 20. Epub 2017 Apr 20.
    Laboratory of Molecular Biology, Universidade Federal de Sergipe (UFS), Brazil.
    It is well established that helper T cell responses influence resistance or susceptibility to Mycobacterium leprae infection, but the role of more recently described helper T cell subsets in determining severity is less clear. To investigate the involvement of Th17 cells in the pathogenesis of leprosy, we determined the immune profile with variant presentations of leprosy. Firstly, IL-17A, IFN-γ and IL-10 were evaluated in conjunction with CD4(+) T cell staining by confocal microscopy of lesion biopsies from tuberculoid (TT) and lepromatous (LL) patients. Read More

    Trend of leprosy in individuals under the age of 15 in Mato Grosso (Brazil), 2001-2013.
    Rev Saude Publica 2017 Apr 10;51:28. Epub 2017 Apr 10.
    Programa de Pós-Graduação. Faculdade de Enfermagem. Universidade de Cuiabá e Universidade Federal de Mato Grosso. Cuiabá, MT, Brasil.
    Objective: To identify the historical trend of leprosy epidemiological indicators in individuals under the age of 15 in the state of Mato Grosso.

    Methods: Descriptive study with trend analysis of leprosy indicators in individuals under the age of fifteen registered in the Mato Grosso's System for Notifiable Diseases between 2001 and 2013. We used the Prais-Winsten procedure for analyzing generalized linear regression at a significance level of 5%. Read More

    Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis.
    PLoS One 2017 18;12(4):e0175743. Epub 2017 Apr 18.
    Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular, Centro Biomédico, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, Rio de Janeiro, Brazil.
    Leprosy is a chronic granulomatous infection of skin and peripheral nerves caused by Mycobacterium leprae and is considered the main infectious cause of disability worldwide. Despite the several studies regarding leprosy, little is known about its effects on microvascular structure and function in vivo. Thus, we have aimed to compare skin capillary structure and functional density, cutaneous vasomotion (spontaneous oscillations of arteriolar diameter), which ensures optimal blood flow distribution to skin capillaries) and cutaneous microvascular blood flow and reactivity between ten men with lepromatous leprosy (without any other comorbidity) and ten age- and gender-matched healthy controls. Read More

    Quinolone resistance-associated amino acid substitutions affect enzymatic activity of Mycobacterium leprae DNA gyrase.
    Biosci Biotechnol Biochem 2017 Apr 18:1-5. Epub 2017 Apr 18.
    a Division of Bioresources , Hokkaido University Research Center for Zoonosis Control , Sapporo , Japan.
    Quinolones are important antimicrobials for treatment of leprosy, a chronic infectious disease caused by Mycobacterium leprae. Although it is well known that mutations in DNA gyrase are responsible for quinolone resistance, the effect of those mutations on the enzymatic activity is yet to be studied in depth. Hence, we conducted in vitro assays to observe supercoiling reactions of wild type and mutated M. Read More

    Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy.
    Neurosci Lett 2017 Apr 12;649:85-92. Epub 2017 Apr 12.
    Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China. Electronic address:
    Post-operative cognitive dysfunction (POCD) is a commonly seen postoperative complication in elderly patients and its underlying mechanisms are still unclear. Autophagy, a degradation mechanism of cellular components, is required for cell survival and many physiological processes. Although propofol is one of the most commonly used intravenous anesthetics, investigations into its mechanisms and effects on cognition in aged rodents are relatively scarce. Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Clinicoepidemiological and Mycological Study of Tinea Capitis in the Pediatric Population of Kashmir Valley: A Study from a Tertiary Care Centre.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):100-103
    Department of Microbiology, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.
    Background: Tinea capitis is a superficial fungal infection that predominantly affects the pediatric population. The etiological factors vary from region to region, and the exact incidence remains obscure. The clinicoepidemiological and mycological aspects of this dermatophytosis were studied in a tertiary care centre in Kashmir valley. Read More

    Economic support intervention improves tuberculosis treatment outcomes in rural Nigeria.
    Int J Tuberc Lung Dis 2017 May;21(5):564-570
    Department of Community Health and Psychiatry, University of West Indies, Kingston, Jamaica.
    Setting: A secondary care hospital in rural Nigeria.

    Objective: To investigate the feasibility of providing financial incentives to tuberculosis (TB) patients under routine conditions, and to determine their impact on TB treatment outcomes in a low-resource setting.

    Design: A prospective, non-randomised intervention study. Read More

    "The legacy of thalidomide" - A multidisciplinary meeting held at the University of York, United Kingdom, on September 30, 2016.
    Birth Defects Res 2017 Mar 10;109(4):296-299. Epub 2017 Feb 10.
    Department of Health Sciences, Faculty of Sciences, University of York, Area 2 Seebohm Rowntree Building, Heslington, York.
    Background: Between 1957 and 1962 thalidomide was used as a nonaddictive, nonbarbiturate sedative that also was successful in relieving the symptoms of morning sickness in early pregnancy. Infamously, thousands of babies were subsequently born with severe birth defects. The drug is used again, today, to successfully treat leprosy, and tragically, there is a new generation of thalidomide damaged children in Brazil. Read More

    Patch testing and cross sensitivity study of adverse cutaneous drug reactions due to anticonvulsants: A preliminary report.
    World J Methodol 2017 Mar 26;7(1):25-32. Epub 2017 Mar 26.
    T N Shiny, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan, Ritu Rawat, Rajni Sharma, Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Himachal Pradesh 176001, India.
    Aim: To evaluate the utility of patch test and cross-sensitivity patterns in patients with adverse cutaneous drug reactions (ACDR) from common anticonvulsants.

    Methods: Twenty-four (M:F = 13:11) patients aged 18-75 years with ACDR from anticonvulsants were patch tested 3-27 mo after complete recovery using carbamazepine, phenytoin, phenobarbitone, lamotrigine, and sodium valproate in 10%, 20% and 30% conc. in pet. Read More

    Functional Toll-Like Receptor (TLR)2 polymorphisms in the susceptibility to inflammatory bowel disease.
    PLoS One 2017 7;12(4):e0175180. Epub 2017 Apr 7.
    Department of Medicine II, Ludwig-Maximilians-University, Munich, Germany.
    Background: The recent genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) suggest significant genetic overlap with complex mycobacterial diseases like tuberculosis or leprosy. TLR variants have previously been linked to susceptibility for mycobacterial diseases. Here we investigated the contribution to IBD risk of two TLR2 polymorphisms, the low-prevalence variant Arg753Gln and the GTn microsatellite repeat polymorphism in intron 2. Read More

    Plants in our combating strategies against Mycobacterium tuberculosis: progress made and obstacles met.
    Pharm Biol 2017 Dec;55(1):1536-1544
    a Department of Biochemistry , National JALMA Institute for Leprosy & Other Mycobacterial Diseases (ICMR) , Agra , India.
    Context: Traditionally used plants for treating chest-related problems/tuberculosis (TB) have not been evaluated in detail and hence a thorough study is needed in this regard. This knowledge may find application in developing new anti-TB drugs.

    Objective: This article elaborates on studying the activity of medicinal plants against different forms of Mycobacterium tuberculosis (Mtb) using different model strains, in vitro and ex vivo assays for studying the tuberculocidal activity and discusses the results from different studies on the activity against different forms of Mtb and human immunodeficiency virus-tuberculosis (HIV-TB) co-infection. Read More

    Enzymatic and Non-Enzymatic Virulence Activities of Dermatophytes on Solid Media.
    J Clin Diagn Res 2017 Feb 1;11(2):DC23-DC25. Epub 2017 Feb 1.
    Professor, Department of Dermatology, Venereology and Leprosy, Sri Ramachandra University , Chennai, Tamil Nadu, India .
    Introduction: Dermatophytes are keratinophilic fungi causing superficial cutaneous infections that account 20-25% of the global population. As per literature search, there is a dearth in the study on virulence factors of dermatophytes from the Indian sub-continent and moreover the association of the virulence factors and the host tissue in vitro helps in understanding the host-pathogen interaction.

    Aim: To analyse the enzymatic and non-enzymatic virulence activities of dermatophytes on solid media. Read More

    M. tuberculosis Hypothetical Proteins and Proteins of Unknown Function: Hope for Exploring Novel Resistance Mechanisms as well as Future Target of Drug Resistance.
    Front Microbiol 2017 21;8:465. Epub 2017 Mar 21.
    Department of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.
    Drug resistance in tuberculosis predominantly, mono-resistance, multi drug resistance, extensively drug resistance and totally drug resistance have emerged as a major problem in the chemotherapy of tuberculosis. Failures of first and second line anti-tuberculosis drugs treatment leads to emergence of resistant Mycobacterium tuberculosis. Few genes are reported as the principal targets of the resistance and apart from the primary targets many explanations have been proposed for drug resistance but still some resistance mechanisms are unknown. Read More

    Current status of Mycobacterium avium subspecies paratuberculosis infection in animals & humans in India: What needs to be done?
    Indian J Med Res 2016 Nov;144(5):661-671
    Department of Microbiology and Molecular Biology, National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
    Mycobacterium avium subspecies paratuberculosis (MAP) has emerged as a major health problem for domestic livestock and human beings. Reduced per animal productivity of domestic livestock seriously impacts the economics of dairy farming globally. High to very high bioload of MAP in domestic livestock and also in the human population has been reported from north India. Read More

    AZALEP a randomized controlled trial of azathioprine to treat leprosy nerve damage and Type 1 reactions in India: Main findings.
    PLoS Negl Trop Dis 2017 Mar 30;11(3):e0005348. Epub 2017 Mar 30.
    Leprosy Mission Trust India, Noida, India.
    Background: Leprosy Type 1 reactions are difficult to treat and only 70% of patients respond to steroid treatment. Azathioprine has been used as an immune-suppressant and we tested its efficacy in treating leprosy T1R.

    Methodology: Randomised controlled trial adding azathioprine to steroid treatment for leprosy reactions. Read More

    Role of Parental Smoking in Severe Bronchiolitis: A Hospital Based Case-Control Study.
    Int J Pediatr 2017 5;2017:9476367. Epub 2017 Mar 5.
    Department of Paediatrics, Sylhet MAG Osmani Medical College, Bangladesh.
    Objective. Bronchiolitis is one of the commonest causes of hospitalization of infants and young children in Bangladesh. About 21% of under 5 children attending different hospitals of Bangladesh have bronchiolitis. Read More

    sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis.
    PLoS Negl Trop Dis 2017 Mar 29;11(3):e0005486. Epub 2017 Mar 29.
    Laboratório de Biologia Molecular-Hospital Universitário-Universidade Federal de Sergipe-Aracaju-Brazil.
    Background: CD163, receptor for the haptoglobin-hemoglobin complex, is expressed on monocytes/macrophages and neutrophils. A soluble form of CD163 (sCD163) has been associated with the M2 macrophage phenotype, and M2 macrophages have been shown to down-modulate inflammatory responses. In particular, previous studies have shown that M2 is closely associated with the most severe clinical presentation of leprosy (i. Read More

    LRRK2 and the Immune System.
    Adv Neurobiol 2017 ;14:123-143
    School of Medical Sciences, University of NSW, Kensington, NSW, 2052, Australia.
    Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of Crohn's inflammatory bowel disease, and increased susceptibility to leprosy. As well as LRRK2 mutations, these diseases share in common immune dysfunction and inflammation. LRRK2 is highly expressed in particular immune cells and has been biochemically linked to the intertwined pathways regulating inflammation, mitochondrial function, and autophagy/lysosomal function. Read More

    A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum.
    Front Immunol 2017 13;8:233. Epub 2017 Mar 13.
    Faculty of Infectious and Tropical Diseases, Clinical Research Department, London School of Hygiene and Tropical Medicine , London , UK.
    Erythema nodosum leprosum (ENL) is a painful inflammatory complication of leprosy occurring in 50% of lepromatous leprosy patients and 5-10% of borderline lepromatous patients. It is a significant cause of economic hardship, morbidity and mortality in leprosy patients. Our understanding of the causes of ENL is limited. Read More

    Identification of Contact Allergens in Food Handlers of Kashmir Valley in North India.
    Dermatitis 2017 Mar 24. Epub 2017 Mar 24.
    Address reprint requests to Iffat Hassan, MD, Department of Dermatology, Sexually Transmitted Diseases & Leprosy, Government Medical College, Srinagar, University of Kashmir, J&K, India 190010. E-mail: Address reprint requests to Iffat Hassan, MD, Department of Dermatology, Sexually Transmitted Diseases & Leprosy, Government Medical College, Srinagar, University of Kashmir, J&K, India 190010. E-mail: Department of Dermatology, Sexually Transmitted Diseases & Leprosy, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.

    Diagnostic delay and associated factors among patients with pulmonary tuberculosis in Dar es Salaam, Tanzania.
    Infect Dis Poverty 2017 Mar 24;6(1):64. Epub 2017 Mar 24.
    Ifakara Health Institute, Bagamoyo Research and Training Centre (BRTC), P O Box 74, Bagamoyo, Tanzania.
    Background: Tanzania is among the 30 countries with the highest tuberculosis (TB) burdens. Because TB has a long infectious period, early diagnosis is not only important for reducing transmission, but also for improving treatment outcomes. We assessed diagnostic delay and associated factors among infectious TB patients. Read More

    Development of a rapid loop-mediated isothermal amplification assay for diagnosis and assessment of cure of Leishmania infection.
    BMC Infect Dis 2017 Mar 23;17(1):223. Epub 2017 Mar 23.
    National Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, 110029, India.
    Background: Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test is warranted for on-time diagnosis and field application. Read More

    Borderline Tuberculoid Leprosy Masquerading as Granuloma Annulare: A Clinical and Histological Pitfall.
    Am J Dermatopathol 2017 Apr;39(4):296-299
    *Keck School of Medicine, University of Southern California, Los Angeles, CA; andDepartments of †Dermatology, and‡Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA.
    Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae, an intracellular acid-fast bacillus that tends to infect the skin and peripheral nerves. Because of the wide array of cutaneous manifestation, diagnosis is not always straightforward, especially in nonendemic regions of the world such as the United States.

    Case Report: The authors report an unusual case of borderline tuberculoid leprosy in an 80-year-old white woman from California. Read More

    A tale of two neglected tropical infections: using GIS to assess the spatial and temporal overlap of schistosomiasis and leprosy in a region of Minas Gerais, Brazil.
    Mem Inst Oswaldo Cruz 2017 Apr;112(4):275-280
    Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, GA, United States.
    Background: Despite public health efforts to reduce the global burden of leprosy, gaps remain in the knowledge surrounding transmission of infection. Helminth co-infections have been associated with a shift towards the lepromatous end of the disease spectrum, potentially increasing transmission in co-endemic areas.

    Objectives: Using this biologically plausible association, we conducted a geographic information systems (GIS) study to investigate the spatial associations of schistosomiasis and leprosy in an endemic area of Minas Gerais (MG), Brazil. Read More

    Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy.
    Mem Inst Oswaldo Cruz 2017 Apr 2;112(4):260-268. Epub 2017 Mar 2.
    Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil.
    Background: Leprosy or hansen's disease is a spectral disease whose clinical forms mostly depends on host's immune and genetic factors. Different Toll-like receptors (TLR) variants have been described associated with leprosy, but with some lack of replication across different populations.

    Objectives: To evaluate the role of polymorphisms in genes TLR1, TLR2 and TLR4 and susceptibility to leprosy in a genetic case control study; to verify the association between genotypes of these markers and the immunological profile in the serum of patients with leprosy. Read More

    Response of iNOS and its relationship with IL-22 and STAT3 in macrophage activity in the polar forms of leprosy.
    Acta Trop 2017 Mar 19;171:74-79. Epub 2017 Mar 19.
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil; Centro de ciências Biológicas e da Saúde, Universidade do Estado do Para, Belem, Brazil. Electronic address:
    Leprosy is a chronic granulomatous infection that manifests as different clinical forms related to the immunological response. The aim of the study was to evaluated the response of IL-22, STAT3, CD68 and iNOS in leprosy skin lesions. The mean number IL-22 positive cells was 12. Read More

    Report of Platythomisus octomaculatus (C. L. Koch, 1845) and Platythomisus sudeepi Biswas, 1977 from India (Araneae, Thomisidae).
    Biodivers Data J 2017 31(5):e10294. Epub 2017 Jan 31.
    Makunda Christian Leprosy and General Hospital, Bazaricherra, District Karimganj, Assam, India.
    Background: The genus Platythomisus Doleschall, 1859 presently comprises 13 valid species, nine known from Africa and four from Asia. All Platythomisus species are known from females only, except P. jucundus Thorell, 1894 and P. Read More

    Vitamin D receptor expression and hepcidin levels in the protection or severity of leprosy: a systematic review.
    Microbes Infect 2017 Mar 16. Epub 2017 Mar 16.
    Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
    Leprosy is a chronic infectious disease whose disequilibrium in the host's genetic, immunological and clinical mechanisms leads to distinct manifestations defining the type of immunological response. This review focuses its attention on the influence of the Vitamin D Receptor and hepcidin expressions that can suggest the protection or severity of leprosy. Read More

    Histoid leprosy: a retrospective clinicopathological study from central Nepal.
    Int J Dermatol 2017 Mar 21. Epub 2017 Mar 21.
    Dermatology, College of Medical Sciences, Bharatpur, Nepal.
    Background: Histoid leprosy is a rare variant of lepromatous leprosy characterized by varied morphological and histopathological appearance while having a high bacillary load. These factors contribute to an ominous threat to the elimination status of leprosy, whereby these patients may act as a reservoir of infection.

    Objective: To identify the clinicopathological characteristics of histoid leprosy in Chitwan, Nepal. Read More

    Evaluation of pulmonary tuberculosis case detection improvement with the deployment of XpertMTB/Rif in the tuberculosis control program of cross River State, Nigeria.
    Int J Mycobacteriol 2017 Jan-Mar;6(1):94-96
    Department of Medical Microbiology and Parasitology, University of Calabar; Institute of Tropical Disease Research and Prevention, University of Calabar Teaching Hospital, Calabar, Nigeria.
    Objective/background: Global indices show that Nigeria has the highest tuberculosis (TB)-related mortality rate. Overdependence on Ziehl-Neelsen (ZN) smear microscopy for diagnosis and human immunodeficiency virus (HIV)/AIDS has limited control efforts. The new polymerase chain reaction-based XpertMTB/Rif (Cepheid Inc. Read More

    Performance of the Xpert MTB/RIF assay in the diagnosis of tuberculosis in formalin-fixed, paraffin-embedded tissues.
    Int J Mycobacteriol 2017 Jan-Mar;6(1):87-93
    Department of Infection, Division of Infection and Immunity, University College London; National Institute for Health Research Biomedical Research Centre at UCL Hospitals, London, United Kingdom.
    Objective/background: Extrapulmonary tuberculosis (EPTB), which accounts for 10%-40% of the global burden of TB, with the highest incidence in Sub-Saharan Africa, is strongly associated with human immunodeficiency virus infection. Diagnosing EPTB is challenging, and recently, there has been a concerted effort to evaluate the latest molecular diagnostics for diagnosing TB in a range of specimen types. The Xpert MTB/RIF assay (Cepheid, Sunnyvale, CA, USA) is one such technology, which simultaneously detects Mycobacterium tuberculosis and rifampicin resistance. Read More

    Mycobacterium lepraemurium uses TLR-6 and MR, but not lipid rafts or DC-sign, to gain access into mouse macrophages.
    Int J Mycobacteriol 2017 Jan-Mar;6(1):52-60
    Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de, México.
    Objective/background: Mycobacterium lepraemurium (MLM), the etiologic agent of murine leprosy, is an intracellular parasite of macrophages; the mechanism used by this bacterium to enter macrophages is not known. The fate of the MLM phagosome inside macrophages is also unknown. This study was conducted to investigate how MLM enters macrophages and to define the maturation process of MLM phagosome inside macrophages. Read More

    Analysis of a novel multiplex polymerase chain reaction assay as a sensitive tool for the diagnosis of indeterminate and tuberculoid forms of leprosy.
    Int J Mycobacteriol 2017 Jan-Mar;6(1):1-8
    Division of Molecular Biology and Immunology, Schieffelin Institute of Health Research and Leprosy Centre, Karigiri, Vellore, Tamil Nadu, India.
    Objective/background: Clinical diagnosis of indeterminate and tuberculoid leprosy is often difficult due to limited and confounding signs and symptoms. In the current study, we evaluated the utility of new multiplex polymerase chain reaction (PCR) using Mycobacterium leprae-specific DNA sequences in the pseudogene regions of ML1545, ML2180, and ML2179 for PCR-based diagnosis of indeterminate leprosy (IND) and leprosy cases across the immunological spectrum. The sensitivity was compared with that of RLEP PCR. Read More

    Association of Nitric Oxide Synthase2 gene polymorphisms with leprosy reactions in northern Indian population.
    Infect Genet Evol 2017 Mar 16;51:67-73. Epub 2017 Mar 16.
    Immunology Division, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, India. Electronic address:
    The pathogen Mycobacterium leprae causes leprosy that affects mainly skin and nerves. Polymorphisms of certain genes are substantiated to be associated with the susceptibility/resistance to leprosy. The present investigation addressed the association of Nitric Oxide Synthase2 gene polymorphisms and leprosy in a population from northern part of India. Read More

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