27,415 results match your criteria Leprosy


Dermatoscopy in leprosy and its correlation with clinical spectrum and histopathology: A prospective observational study.

J Eur Acad Dermatol Venereol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Venereology, Leprology, Post Graduate Institute of Medical Education and Research, Sector 12Chandigarh, India.

Background: Leprosy is a chronic granulomatous infection with varied clinical presentations. In this study, we aimed to describe the dermatoscopic features of the entire spectrum of leprosy and to correlate with clinical and histopathological findings.

Methodology: This was a prospective observational study of treatment naïve leprosy patients over a period of 1 year. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15635
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http://dx.doi.org/10.1111/jdv.15635DOI Listing
April 2019
1 Read
2.826 Impact Factor

Rationale in diagnosis and management: role of screening and history taking.

Trop Doct 2019 Apr 18:49475519841749. Epub 2019 Apr 18.

2 Assistant Professor, Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

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http://journals.sagepub.com/doi/10.1177/0049475519841749
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http://dx.doi.org/10.1177/0049475519841749DOI Listing
April 2019
1 Read
0.528 Impact Factor

Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin.

Int J Womens Dermatol 2019 Jun 16;5(2):100-104. Epub 2018 Nov 16.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lichen planus (LP) is a chronic inflammatory disease of the skin. Currently, noninvasive techniques are used to evaluate biophysical properties of the skin in vivo.

Objective: In this study, we aimed to evaluate skin biophysical properties in patients with LP and make a comparison between involved and uninvolved skin to provide a better understanding of the pathogenesis of LP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183004
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http://dx.doi.org/10.1016/j.ijwd.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451735PMC
June 2019
1 Read

Changing stigmatisation of leprosy: an exploratory, qualitative life course study in Western Nigeria.

BMJ Glob Health 2019 7;4(2):e001250. Epub 2019 Mar 7.

Faculty of Clinical Sciences, Lagos State University, Department of Behavioural Medicine, Ikeja, Nigeria.

Introduction: Renewed interest in health-related stigma has invigorated calls to understand factors and processes underlying stigma. However, few empirical studies explore the influences of structural discrimination and moral status on leprosy-related stigma. We investigated how sociocultural context and organisational policies and practices influenced the connotations of leprosy, sources of stigma and the changing social responses to leprosy in Western Nigeria. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441294PMC

Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Division of Dermatology, Department of Medicine, and.

DC, through the uptake, processing, and presentation of antigen, are responsible for activation of T cell responses to defend the host against infection, yet it is not known if they can directly kill invading bacteria. Here, we studied in human leprosy, how Langerhans cells (LC), specialized DC, contribute to host defense against bacterial infection. IFN-γ treatment of LC isolated from human epidermis and infected with Mycobacterium leprae (M. Read More

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https://insight.jci.org/articles/view/126955
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http://dx.doi.org/10.1172/jci.insight.126955DOI Listing
April 2019
1 Read

Adverse events in patients with leprosy on treatment with thalidomide.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180385. Epub 2019 Apr 11.

Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic.

Methods: A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Read More

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http://dx.doi.org/10.1590/0037-8682-0385-2018DOI Listing

Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180172. Epub 2019 Apr 11.

Divisão de Dermatologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Introduction: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce.

Methods: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases. Read More

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http://dx.doi.org/10.1590/0037-8682-0172-2018DOI Listing
April 2019
1 Read

Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

l-Asparaginases hydrolyzing plasma l-asparagine and l-glutamine has attracted tremendous attention in recent years owing to remarkable anticancer properties. This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in children, neoplasia, and some other malignancies. Cancer cells reduce the expression of l-asparaginase leading to their elimination. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28563
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http://dx.doi.org/10.1002/jcp.28563DOI Listing
April 2019
2 Reads

Schizophrenia-like psychosis as the presenting feature of neurosyphilis in a non-human immunodeficiency virus-infected Indian man: A reminder of a forgotten complication!

Indian J Psychiatry 2019 Mar-Apr;61(2):213-216

Department of Neurology, N.R.S. Medical College, Kolkata, West Bengal, India.

Syphilis is a great masquerader of several diseases. About 4%-10% of patients with untreated syphilis may develop neurosyphilis (NS). Psychiatric manifestations may rarely be the presenting feature of NS. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_330_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425800PMC
April 2019
1 Read

Delay in tuberculosis diagnosis and treatment in Amhara state, Ethiopia.

BMC Health Serv Res 2019 Apr 16;19(1):232. Epub 2019 Apr 16.

North Shoa Zone Health Department Tuberculosis, HIV and Leprosy program coordinator, Debre Birhan, Shoa, Ethiopia.

Background: Delayed presentation is a major problem contributing to the high burden and transmission of tuberculosis (TB) in developing countries. The delay may be due to patient delay if the patient visits health-facility for diagnosis after the onset of symptoms of more than 3 weeks or health system delay if the patient is not diagnosed and treated at the time of the first visit. Ethiopia, where no more than two-thirds of TB cases are detected is no exception. Read More

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http://dx.doi.org/10.1186/s12913-019-4056-7DOI Listing

Graham-Little-Piccardi-Lasseur Syndrome.

Authors:
Gunjan Verma

Indian Dermatol Online J 2019 Mar-Apr;10(2):180-181

Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_360_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434740PMC
April 2019
1 Read

Recent Laboratory Advances in Diagnostics and Monitoring Response to Treatment in Leprosy.

Authors:
Utpal Sengupta

Indian Dermatol Online J 2019 Mar-Apr;10(2):106-114

Departemnt of Microbiology and Immunology, Stanley Browne Laboratory, TLM Community Hospital, Nand Nagri, New Delhi, India.

The present review briefly summarizes the highlights of the recent advances in -specific tests for early diagnosis of leprosy. In addition to establishing the diagnosis of clinical cases of leprosy, these tests have also been used to detect subclinical infections in endemic population. Several attempts have been made from 1980 onward for standardization of specific diagnostic assays for early detection of leprosy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_260_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434766PMC
April 2019
1 Read

Typing of isolates by phenotypic and genotypic techniques in New Delhi, India.

J Lab Physicians 2019 Jan-Mar;11(1):45-50

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: The objective of this study is to investigate gonococcal isolates using phenotypic and genotypic methods.

Methodology: Sixty gonococcal isolates obtained were examined. Strains were divided into 9 resistant phenotypes: Chromosomally mediated penicillin-resistant (CMRNGP), penicillinase-producing NG (PPNG), chromosomally mediated tetracycline-resistant NG (CMRNG), TRNG, PPNG and TRNG, CMRNG, quinolone resistant NG (QRNG), Azithro R, and decreased susceptibility (DS) to ceftriaxone. Read More

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http://dx.doi.org/10.4103/JLP.JLP_107_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437833PMC

Chronic Arsenicosis: Cases from a Nonendemic Area of South Rajasthan.

Indian J Dermatol 2019 Mar-Apr;64(2):164

Department of Dermatology, Rajmata Vijaya Raje Scindia Government Medical College, Bhilwara, Rajasthan, India.

Two adult patients from a village of district Bhilwara, Rajasthan, consulted Skin Department of R. N. T. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/164/254170
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http://dx.doi.org/10.4103/ijd.IJD_704_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440183PMC
April 2019
3 Reads

Clinico-epidemiological Study of Disability Due to Leprosy at the Time of Diagnosis among Patients Attending a Tertiary Care Institution.

Indian J Dermatol 2019 Mar-Apr;64(2):106-111

Department of Dermatology and Venereology, Government Medical College, Kozhikode, Kerala, India.

Background: With the declared elimination of leprosy as a public health problem, the World Health Organization has shifted the focus on the disabilities and deformities associated with leprosy.

Aims: The aim was to study the Grade 1 and Grade 2 disability among newly diagnosed leprosy patients.

Materials And Methods: All newly diagnosed leprosy patients attending the Outpatient Department of Government Medical College, Kozhikode, from January 1, 2013 to December 31, 2013 were included in the study and the Grade 1 and Grade 2 disabilities observed were analyzed. Read More

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http://dx.doi.org/10.4103/ijd.IJD_185_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440182PMC

Biophysical Measurements and Ultrasonographic Findings in Chronic Dermatitis in Comparison with Uninvolved Skin.

Indian J Dermatol 2019 Mar-Apr;64(2):90-96

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nowadays noninvasive techniques are performed to evaluate the biophysical properties of skin .

Aims: The aim of this study was to evaluate the biophysical and ultrasonographic properties of skin in chronic contact or atopic dermatitis to provide better insight into pathogenesis, diagnosis, and treatment response.

Materials And Methods: The stratum corneum hydration, transepidermal water loss (TEWL), pH, erythema, melanin, sebum, friction, temperature, elasticity parameters (R0, R2, and R5), the thickness and echo-density of epidermis, dermis, and subepidermal low-echogenic band (SLEB) were measured on lesional, perilesional, and symmetrical skin of 22 chronic dermatitis patients. Read More

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http://dx.doi.org/10.4103/ijd.IJD_464_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440184PMC
April 2019
4 Reads

Spontaneously regressing acral congenital leucoderma.

Australas J Dermatol 2019 Apr 14. Epub 2019 Apr 14.

Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry University, Pondicherry, India.

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http://dx.doi.org/10.1111/ajd.13055DOI Listing
April 2019
0.982 Impact Factor

Late onset nevus comedonicus of scalp: a rare site for an uncommon condition.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia Post Graduate Institute of Medical Education and Research, New Delhi.

Nevus comedonicus is an uncommon hamartoma of the pilosebaceous unit characterized by keratin filled pits simulating open comedones. It may present at birth but is more commonly seen during childhood or adolescence. The most commonly affected sites are the face, neck, trunk, and arms with a few reported cases on palms, genitalia, and scalp. Read More

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The nail flag sign in heart transplant recipients: case reports and review of the patients with the flag sign of the nail.

Authors:
Philip R Cohen

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

San Diego Family Dermatology, National City, California.

The nail plate flag sign is a distinctive nail plate change that appears as white, red, white, and red sequential transverse bands beginning at the proximal nail fold. This distinctive nail change was initially described in patients with diabetes mellitus and leprosy; indeed, it was considered to be characteristic, but not diagnostic of leprosy. Subsequently, the flag sign was observed in patients with vitiligo. Read More

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March 2019
1 Read

The rash that becomes an erythroderma.

Clin Dermatol 2019 Mar - Apr;37(2):88-98. Epub 2018 Dec 5.

Department of Dermatology, Venereology & Leprosy, ESI Medical College & Hospital, Bengaluru, Karnataka, India.

Erythroderma is a dermatologic emergency with potentially serious consequences. Several diseases with different etiologies characteristically appear as erythroderma. Depending on the age groups, congenital ichthyosiform disorders, infections, preexisting dermatoses, drug eruptions, and internal malignancies commonly present with, or progress to, erythroderma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.002DOI Listing
December 2018
2 Reads

The rash with painful and erythematous nodules.

Clin Dermatol 2019 Mar - Apr;37(2):129-135. Epub 2018 Dec 5.

Department of Dermatology, Venereology & Leprosy, Shri B. M. Patil Medical College, Hospital & Research Center, BLDE Deemed University, Vijayapur, Karnataka, India.

Erythematous painful cutaneous nodular lesions are associated with a host of disorders that may erupt acutely as a generalized or localized dermatitis or be associated with chronic and/or recurrent illnesses. This review discusses such disorders presenting with painful nodular lesions and attempts to provide a systematic approach to their clinical diagnosis. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.12.006DOI Listing
December 2018

Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania.

PLoS One 2019 12;14(4):e0206334. Epub 2019 Apr 12.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Human tuberculosis (TB) is caused by seven phylogenetic lineages of the Mycobacterium tuberculosis complex (MTBC), Lineage 1-7. Recent advances in rapid genotyping of MTBC based on single nucleotide polymorphisms (SNP), allow for phylogenetically robust strain classification, paving the way for defining genotype-phenotype relationships in clinical settings. Such studies have revealed that, in addition to host and environmental factors, strain variation in the MTBC influences the outcome of TB infection and disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206334PLOS
April 2019
4 Reads

Gridlock from diagnosis to treatment of multidrug-resistant tuberculosis in Tanzania: low accessibility of molecular diagnostic services and lack of healthcare worker empowerment in 28 districts of 5 high burden TB regions with mixed methods evaluation.

BMC Public Health 2019 Apr 11;19(1):395. Epub 2019 Apr 11.

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA.

Background: Multidrug-resistant tuberculosis (MDR-TB) outcomes are adversely impacted by delay in diagnosis and treatment.

Methods: Mixed qualitative and quantitative approaches were utilized to identify healthcare system related barriers to implementation of molecular diagnostics for MDR-TB. Randomly sampled districts from the 5 highest TB burden regions were enrolled during the 4th quarter of 2016. Read More

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http://dx.doi.org/10.1186/s12889-019-6720-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458695PMC
April 2019
52 Reads
2.264 Impact Factor

Comparison of the Clinical Characteristics and Outcomes between Leprosy-Affected Persons in Sorokdo and the General Population Affected by Chronic Hepatitis C in Korea.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Gastroenterology, Chonnam National University Hospital, Gwangju, South Korea.

Background/aims: : Patients with Hansen’s disease are the most vulnerable to hepatitis C; however, no data on the treatment efficacy of direct-acting antiviral agents (DAAs) are available in this group. Therefore, we elucidated the prevalence and clinical outcomes of hepatitis C in persons affected by leprosy in Sorokdo, Jeollanam-do, Korea.

Methods: : We retrospectively included 50 leprosy patients with positive hepatitis C virus (HCV) RNA test results (group A) hospitalized at the Sorokdo National Hospital from May 2016 to March 2018 and 73 patients with chronic hepatitis C who were treated with DAAs at the Chonnam National University Hospital (group B) from May 2016 to December 2017. Read More

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http://dx.doi.org/10.5009/gnl18432DOI Listing
February 2019
1 Read

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.

Cell Rep 2019 Apr;27(2):561-571.e6

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan.

Severe invasive group A Streptococcus (GAS) infection evades anti-bacterial immunity by attenuating the cellular components of innate immune responses. However, this loss of protection is compensated for by interferon (IFN)-γ-producing immature myeloid cells (γIMCs), which are selectively recruited upon severe invasive GAS infection in mice. Here, we demonstrate that γIMCs provide this IFN-γ-mediated protection by sequentially sensing GAS through two distinct pattern recognition receptors. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.056DOI Listing
April 2019
2 Reads

Leprosy transmission in Bahia, 2001-2015: modeling based on Jointpoint regression and spatial scan statistics.

Epidemiol Serv Saude 2019 8;28(1):e2018065. Epub 2019 Apr 8.

Fundação Instituto Oswaldo Cruz, Instituto de Comunicação e Informação Científica e Tecnológica em Saúde, Rio de Janeiro, RJ, Brasil.

Objective: to describe the trend and the spatial distribution of leprosy in the state of Bahia, Brazil, 2001-2015.

Methods: this was a mixed ecological study of epidemiological indicators of leprosy; Jointpoint regression was used for the temporal analysis, while spatial scan statistics were used to identify clusters of the disease; the trend was classified as stationary, increasing or decreasing; we calculated the annual percent change (APC) and average annual percent change (AAPC).

Results: there was a reduction in prevalence (AAPC = -5. Read More

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http://dx.doi.org/10.5123/S1679-49742019000100015DOI Listing

Quick and brief review: Comparison between different in vivo SPF determination methods.

J Cosmet Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Center for Research & Training in Skin Diseases & Leprosy (CRTSDL), Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Background: The use of sunscreen products has grown considerably in the last few decades because sunscreen products considered as one of the most important ways of skin protection against UV rays by different mechanisms such as reflecting, absorbing, or scattering. Excess expose to UV causes sunburn, early skin aging, and skin cancers.

Objective: This review aimed to review and compare prominent in vivo sun protection factor (SPF) determination protocols and investigate their approach in test criteria. Read More

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http://dx.doi.org/10.1111/jocd.12941DOI Listing

Seasonality of childhood tuberculosis cases in Kampala, Uganda, 2010-2015.

PLoS One 2019 9;14(4):e0214555. Epub 2019 Apr 9.

Division of Pulmonology and Critical Care Medicine, University of California, San Francisco, San Francisco, United States of America.

Background: Seasonality in tuberculosis (TB) has been described, especially in children. However, few studies have assessed seasonality of TB in the equatorial region, and none in children.

Objectives: To assess for seasonality of childhood TB cases in Kampala, Uganda, and determine the role of temperature, rainfall patterns, and influenza cases on TB diagnoses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214555PLOS
April 2019
1 Read

Pattern of skin diseases in children attending a dermatology clinic in a referral hospital in Wolaita Sodo, southern Ethiopia.

BMC Dermatol 2019 04 8;19(1). Epub 2019 Apr 8.

College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Epidemiological studies to determine the pattern of skin diseases among children are important for proper health care planning and management. The purpose of this study was to describe the pattern of skin diseases among pediatric patients seen at a dermatology outpatient clinic of Wolaita Sodo Teaching and Referral Hospital, southern Ethiopia.

Method: We conducted a retrospective hospital-based, cross-sectional study between January 2016 and December 2017 at a teaching and referral hospital dermatology outpatient department. Read More

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http://dx.doi.org/10.1186/s12895-019-0085-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454754PMC
April 2019
1 Read

Case detection and diagnosis of tuberculosis in primary-care settings.

Paediatr Int Child Health 2019 Apr 8:1-4. Epub 2019 Apr 8.

b International Union Against Tuberculosis and Lung Disease , Paris , France.

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http://dx.doi.org/10.1080/20469047.2019.1597487DOI Listing
April 2019
1 Read

Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

EC Microbiol 2019 Mar;15(3):160-167

Department of Parasitology, Universidad de Granada, Granada, Spain.

Introduction: Onchocerciasis, remains an unfamiliar condition for health professionals in Mozambique leading to its misdiagnosis as leprosy or scabies as noted in previous studies. Meta-analyses conducted in some African countries, have concluded that onchocerciasis is associated with epilepsy and nodding syndrome. Epilepsy affects at least 3% of the Mozambican population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448571PMC
March 2019
1 Read

A case of imported leprosy in Italy: Implications for surveillance by Public Health Services of Local Health Authorities.

Travel Med Infect Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Biomedical and Neuromotor Sciences, Unit of Hygiene, Public Health and Medical Statistics, University of Bologna, via San Giacomo 12, 40126, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2019.04.002DOI Listing
April 2019
2 Reads

The role of perceptions and knowledge of leprosy in the elimination of leprosy: A baseline study in Fatehpur district, northern India.

PLoS Negl Trop Dis 2019 Apr 5;13(4):e0007302. Epub 2019 Apr 5.

NLR, Amsterdam, Netherlands.

Background: With the introduction of new interventions to prevent leprosy, such as post-exposure prophylaxis (PEP) given to contacts of leprosy patients, it is necessary to update our understanding of knowledge and perception of leprosy among the populations where these interventions will be introduced, in order to tailor communication optimally to the current situation. This study is a baseline study of the PEP++ project and aimed to assess the knowledge, attitudes and practices regarding leprosy in Fatehpur, India.

Methodology: The study used a community-based cross-sectional design with a mixed-methods approach. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007302
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http://dx.doi.org/10.1371/journal.pntd.0007302DOI Listing
April 2019
3 Reads

Authors' reply - Transepidermal elimination: Role in leprosy transmission.

Indian J Dermatol Venereol Leprol 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, Katihar Medical College, Katihar, Bihar, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_192_19DOI Listing

Neutrophils in Leprosy.

Front Immunol 2019 19;10:495. Epub 2019 Mar 19.

Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.

Leprosy is an infectious disease caused by the intracellular bacillus that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of leprosy is the diversity of its clinical forms. Paucibacillary patients are characterized as having less than five skin lesions and rare bacilli while the lesions in multibacillary patients are disseminated with voluminous bacilli. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436181PMC
March 2019
2 Reads

Draft Genome Sequence of sp. Strain NCC-Tsukiji, Isolated from Blood Culture of a Patient with Malignant Lymphoma.

Microbiol Resour Announc 2019 Apr 4;8(14). Epub 2019 Apr 4.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan

A nonidentifiable mycolicibacterium was isolated from a malignant lymphoma patient treated with intensive chemoimmunotherapy. Multilocus sequence analysis showed that this isolate was close to " () ," but the details of this species were still unknown. Here, we report the draft genome sequence data of sp. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.01575-18
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http://dx.doi.org/10.1128/MRA.01575-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449561PMC
April 2019
5 Reads

Mycobacterium tuberculosis cysteine biosynthesis genes mec+-cysO-cysM confer resistance to clofazimine.

Tuberculosis (Edinb) 2019 03 6;115:63-66. Epub 2019 Feb 6.

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.

The Mycobacterium tuberculosis mec+-cysO-cysM gene cluster was shown to be part of a novel cysteine biosynthesis pathway in vitro, but little is known about its essentiality or role in M. tuberculosis physiology. In this study, we generate a knock out of the mec+-cysO-cysM gene cluster in M. Read More

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http://dx.doi.org/10.1016/j.tube.2019.02.002DOI Listing
March 2019
5 Reads

Multiple strain infection of Mycobacterium leprae in a family having 4 patients: A study employing short tandem repeats.

PLoS One 2019 4;14(4):e0214051. Epub 2019 Apr 4.

Department of Epidemiology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, M. Miyazaki Marg, Tajganj, Agra, India.

Background: Leprosy is a slow, chronic disorder caused by Mycobacterium leprae. India has achieved elimination of leprosy in December 2005 but new cases are being detected and continue to occur in some endemic pockets. The possible ways of transmission of leprosy is not fully understood and is believed that leprosy is transmitted from person to person in long term contact. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214051PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449029PMC
April 2019
3 Reads

Position statement: LEPROSY: Diagnosis, treatment and follow-up.

J Eur Acad Dermatol Venereol 2019 Apr 3. Epub 2019 Apr 3.

Department of Dermatovenereology, Ayder Referral Hospital Mekelle University, Mekelle, Tigray, Ethiopia.

Background: Leprosy or Hansen's disease is a chronic infection caused by Mycobacterium leprae (M. leprae) or Mycobacterium lepromatosis (M. lepromatosis). Read More

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http://dx.doi.org/10.1111/jdv.15569DOI Listing
April 2019
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Metabolic, pharmacokinetic, and toxicological issues surrounding dapsone.

Expert Opin Drug Metab Toxicol 2019 Apr 4:1-13. Epub 2019 Apr 4.

a Dermatological Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.

Introduction: In their 70-year history, dapsone and other sulfones have been used as both antibacterial and anti-inflammatory agents. Dapsone has been the main active principle in the multidrug regimen recommended by the World Health Organization for the treatment of leprosy. In addition, dapsone has been successfully used to treat a wide range of dermatological and systemic disorders, mostly characterized by neutrophilic and eosinophilic accumulation and infiltration. Read More

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http://dx.doi.org/10.1080/17425255.2019.1600670DOI Listing
April 2019
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Utility of platelet rich fibrin gel therapy in nonhealing ulcer secondary to ecthyma gangrenosum.

Dermatol Ther 2019 Apr 3:e12887. Epub 2019 Apr 3.

Department of Dermatology, Venereology & Leprology, All India Institute of Medical Sciences, Jodhpur, India.

Platelet rich fibrin (PRF) gel is a new second generation platelet concentrate, which has been widely used in various dermatological conditions such as nonhealing diabetic foot ulcers, venous ulcers, and trophic ulcers in leprosy. In this case report, we present a patient with nonhealing ulcer secondary to ecthyma gangrenosum, who showed dramatic response with PRF gel. This case suggests a role of PRF gel in nonhealing ulcers of infectious etiology which has not been described in English language literature. Read More

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http://dx.doi.org/10.1111/dth.12887DOI Listing
April 2019
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Investigating dietary patterns and organisational structure by using stable isotope analysis: a pilot study of the Danish medieval leprosy hospital at Næstved.

Anthropol Anz 2019 Apr 3. Epub 2019 Apr 3.

Department of Earth Sciences, Durham University, United Kingdom.

During the 12 and 13 centuries, numerous leprosy hospitals were founded in Europe. Given that leprosy was not considered infectious, this may reflect social dimensions of the disease. Aiming at exploring the impact of leprosy on medieval people and the organisation of the Danish at Næstved, we reconstructed the diet of twenty patients using stable isotopes, and compared our results with relevant historical data. Read More

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http://dx.doi.org/10.1127/anthranz/2019/0949DOI Listing
April 2019
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Impact of urbanization on tuberculosis and leprosy prevalence in medieval Denmark.

Anthropol Anz 2019 Apr 3. Epub 2019 Apr 3.

Unit of Anthropology (ADBOU), Institute of Forensic Medicine, University of Southern Denmark, Odense, Denmark.

The consequences of urbanization, such as increased exposure to pathogens, have long been considered detrimental to human health. During the first half of the Danish medieval period, towns were established and throughout the period population increased. The following study analyzes the relationship between urbanization and disease frequency - specifically leprosy and tuberculosis - in four skeletal samples from medieval Denmark using a paleoepidemiological approach. Read More

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http://dx.doi.org/10.1127/anthranz/2019/0962DOI Listing
April 2019
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IL-26 contributes to host defense against intracellular bacteria.

J Clin Invest 2019 Apr 2;130. Epub 2019 Apr 2.

Division of Dermatology, Department of Medicine.

IL-26 is an antimicrobial protein secreted by Th17 cells that has the ability to directly kill extracellular bacteria. To ascertain whether IL-26 contributes to host defense against intracellular bacteria, we studied leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, as a model. Analysis of leprosy skin lesions by gene expression profiling and immunohistology revealed that IL-26 was more strongly expressed in lesions from the self-limited tuberculoid compared with expression in progressive lepromatous patients. Read More

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https://www.jci.org/articles/view/99550
Publisher Site
http://dx.doi.org/10.1172/JCI99550DOI Listing
April 2019
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Evaluation of Toll-like receptor expression profile in patients with psoriasis vulgaris.

Gene 2019 Mar 29;702:166-170. Epub 2019 Mar 29.

Department of Medical Biology, Bozok University School of Medicine, Yozgat, Turkey. Electronic address:

TLRs are thought to play a role in the pathophysiology of such dermatological diseases as leprosy, acne and psoriasis. The study included 20 patients with plaque psoriasis, as well as 20 healthy age- and gender-matched control subjects. Real-time polymerase chain reaction evaluation was made of the messenger RNA expression of TLRs 1-10 in lesional tissue and peripheral blood mononuclear cell samples in psoriasis patients. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.058DOI Listing
March 2019
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Response to letter to the editor.

Hum Vaccin Immunother 2019 Apr 1. Epub 2019 Apr 1.

c Department of Leprosy , Wuhan Institute of Dermatology and Venereology , Wuhan , China.

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http://dx.doi.org/10.1080/21645515.2019.1596714DOI Listing

Leprosy in red squirrels in the UK.

Vet Rec 2019 Mar;184(13):416

University of Melbourne, Parkville VIC 3010, Melbourne, Australia.

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http://dx.doi.org/10.1136/vr.l1385DOI Listing
March 2019
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Pediatric Tuberculosis in a Northeast State of Peninsular Malaysia: Diagnostic Classifications and Determinants.

Oman Med J 2019 Mar;34(2):110-117

Tuberculosis and Leprosy Control Unit, Kelantan State Health Department, Kelantan, Malaysia.

Objectives: We sought to determine the total proportion of pediatric tuberculosis cases, characterize tuberculosis by its anatomical location and pretreatment sputum smear status, and to determine the association of the sociodemographic and clinical factors with tuberculosis disease among pediatric patients in Kelantan from 2012 until 2015.

Methods: We conducted a comparative cross-sectional study between tuberculosis cases and tuberculosis contacts among pediatric patients using the Tuberculosis Information System as a source population. All notified cases that fulfilled the inclusion and exclusion criteria were included in the study. Read More

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http://dx.doi.org/10.5001/omj.2019.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425061PMC

Leprosy neuropathy masquerading as cellulitis.

Postgrad Med J 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK.

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http://dx.doi.org/10.1136/postgradmedj-2019-136392DOI Listing
March 2019
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