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    An extremely rare association of Sweet's syndrome with active pulmonary tuberculosis.
    Indian J Tuberc 2018 Jan 19;65(1):87-90. Epub 2017 May 19.
    Indira Gandhi Medical College (IGMC) Shimla, HP, Department of Dermatology, Venereology and Leprosy, Shimla, Himachal Pradesh 171001, India. Electronic address:
    Sweet's syndrome is a skin manifestation of various systemic infections, drugs, malignancies and autoimmune disorders. There are very few case reports describing the relationship between Sweet's syndrome and non-tubercular mycobacterium infection. Further development of Sweet's syndrome secondary to mycobacterium tuberculosis (active pulmonary tuberculosis) is extremely uncommon and this is the second well established case reported from India. Read More

    Current Affairs, Future Perspectives of Tuberculosis and Antitubercular Agents.
    Indian J Tuberc 2018 Jan 14;65(1):15-22. Epub 2017 Aug 14.
    Department of Pharmaceutical Chemistry, SVKM's NMIMS School of Pharmacy and Technology Management, Shirpur Campus, 425 405 MS, India.
    Tuberculosis (TB) is the major threat for humans from past several decades. Even after advent of several antitubercular drugs, researchers are still struggling for the mycobacterial infections in humans are TB and leprosy. Chronic infections caused by Mycobacterium tuberculosis and Mycobacterium leprae. Read More

    Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation.
    PLoS Negl Trop Dis 2018 Jan 12;12(1):e0006141. Epub 2018 Jan 12.
    Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
    Introduction: Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatment recommendations, as shown by systematic reviews on old-world and new-world CL (OWCL and NWCL).

    Materials And Methods: Using a previously published guidance paper on CL treatment trial methodology as the reference, consensus was sought on key parameters including core eligibility and outcome measures, among OWCL (7 countries, 10 trial sites) and NWCL (7 countries, 11 trial sites) during two separate meetings. Read More

    Nail changes in autoimmune blistering disorders: A case-control study.
    Indian J Dermatol Venereol Leprol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
    Background: Pemphigus and pemphigoid disorders produce blistering cutaneous lesions. Earlier case reports state that nail involvement is uncommon in these autoimmune blistering disorders.

    Aims And Objectives: To study nail changes in autoimmune blistering disorders. Read More

    Surveillance of intradomiciliary contacts of leprosy cases: perspective of the client in a hyperendemic municipality.
    Rev Bras Enferm 2018 Jan-Feb;71(1):163-169
    Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo / Universidade Cidade de São Paulo, Postgraduate Program in Health Sciences. São Paulo, Brazil.
    Objective: To characterize approach methods for intradomiciliary contacts (IdC) of leprosy cases resident in Northern Brazil, during 2001-2012.

    Method: A cross-sectional and descriptive study in the state of Rondônia. Included IdC of leprosy cases diagnosed/reported in SINAN-Ministry of Health (MS), 2001-2012. Read More

    Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis.
    Front Microbiol 2017 11;8:2452. Epub 2017 Dec 11.
    Department of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.
    Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of Mycobacterium tuberculosis. Repurposing and revival of the drugs are the new trends/options to combat these worsen situations of tuberculosis in the antibiotics resistance era or in the situation of global emergency. Bactericidal and synergistic effect of repurposed/revived drugs along with the latest drugs bedaquiline and delamanid used in the treatment of MDR-TB, XDR-TB, and TDR-TB might be the choice for future promising combinatorial chemotherapy against these bad bugs. Read More

    Arresting Leprosy: Therapeutic Outcomes Besides Cure.
    Am J Public Health 2018 Feb;108(2):196-202
    Raúl Necochea López is with the Department of Social Medicine and the Department of History, University of North Carolina, Chapel Hill.
    This essay focuses on the use of the concept of "arrest" in Hansen's disease (leprosy) in the United States in the early to middle part of the 20th century, as well as the transformations the concept underwent with the arrival of sulfone drugs and the implications of these changes for patients and public health officers. An "arrest" was a therapeutic outcome characterized by a long course of treatment, noncontagiousness, a very small chance of reactivation, and a need for postdischarge maintenance that depended on sociomedical infrastructures beyond the clinic as well as self-imposed lifestyle limitations. The concept of disease arrest shows that experts and laypeople alike have valued therapeutic outcomes other than "cure" that signal certain optimal therapeutic milestones, despite the practical difficulties they imply and despite the fact that they do not promise a return to a pre-illness stage. Read More

    Granulosis Rubra Nasi Response to Topical Tacrolimus.
    Case Rep Dermatol Med 2017 29;2017:2519814. Epub 2017 Nov 29.
    Department of Dermatology, Venereology & Leprosy, Jawaharlal Nehru Medical College and KLE's Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka 590 010, India.
    Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face, most commonly on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip. It is commonly seen in childhood but it can present in adults. Read More

    Cationic liposomes formulated with a novel whole Leishmania lysate (WLL) as a vaccine for leishmaniasis in murine model.
    Immunobiology 2017 Dec 28. Epub 2017 Dec 28.
    Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whole killed Leishmania showed more successful results in clinical trials. It seems that the main reason for the low efficacy of these vaccines is lack of a suitable adjuvant. Read More

    Immune Checkpoints in Leprosy: Immunotherapy As a Feasible Approach to Control Disease Progression.
    Front Immunol 2017 11;8:1724. Epub 2017 Dec 11.
    Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
    Leprosy remains a health problem in several countries. Current management of patients with leprosy is complex and requires multidrug therapy. Nonetheless, antibiotic treatment is insufficient to prevent nerve disabilities and control Mycobacterium leprae. Read More

    The Medicinal Usage and Restriction of Ginseng in Britain and America, 1660-1900.
    Uisahak 2017 Dec;26(3):503-544
    This article demonstrates the medicinal usage of ginseng in the West from 1660 to 1914. Asian[Korea] ginseng was first introduced into England in the early 17th century, and North American ginseng was found in the early 18th century. Starting from the late 17th century doctors prescribed ginseng to cure many different kinds of ailments and disease such as: fatigue general lethargy, fever, torpidity, trembling in the joints, nervous disorder, laughing and crying hysteria, scurvy, spermatic vessel infection, jaundice, leprosy, dry gripes and constipation, strangury, yellow fever, dysentery, infertility and addictions of alcohol, opium and tobacco, etc. Read More

    ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis.
    J Immunol 2018 Jan 8. Epub 2018 Jan 8.
    Laboratório de Imunobiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Santa Catarina CEP 88040-900, Brazil;
    IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attributed to its extracellular cytokine-like activity. In this study, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, unique to primary human monocytes. A balanced ISG15-induced monocyte/IL-10 versus lymphoid/IFN-γ expression, correlating with p38 MAPK and PI3K signaling, was found using targeted in vitro and ex vivo systems analysis of human transcriptomic datasets. Read More

    Epidemiology of Leprosy in Iran from 2005 to 2015.
    Tanaffos 2017 ;16(2):144-148
    Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
    Background: Leprosy is a chronic infectious disease with permanent complications that mainly affect the skin, peripheral nerves, mucosal surfaces of the upper respiratory tract, and eyes. The aim of this study was to investigate the epidemiology and trends of leprosy in Iran from 2005 to 2015.

    Materials And Methods: This was a cross-sectional study analyzing leprosy records from the Center for Communicable Disease Control, Ministry of Health and Medical Education, during 2005-2015. Read More

    The repetitive element RLEP is a highly specific target for the detection of Mycobacterium leprae.
    J Clin Microbiol 2018 Jan 5. Epub 2018 Jan 5.
    Dept. Biomedical sciences, Institute of Tropical Medicine, Antwerp, Belgium.
    Leprosy, caused by Mycobacterium leprae (M. leprae), is a mutilating and highly stigmatized disease that still affects hundreds of thousands of new patients annually.…. Read More

    Household expenditure on leprosy outpatient services in the Indian health system: A comparative study.
    PLoS Negl Trop Dis 2018 Jan 4;12(1):e0006181. Epub 2018 Jan 4.
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    Background: Leprosy is a major public health problem in many low and middle income countries, especially in India, and contributes considerably to the global burden of the disease. Leprosy and poverty are closely associated, and therefore the economic burden of leprosy is a concern. However, evidence on patient's expenditure is scarce. Read More

    First report of OXA-143-lactamase producing Acinetobacter baumannii in Qom, Iran.
    Iran J Basic Med Sci 2017 Nov;20(11):1282-1286
    Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
    Objectives: Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran.

    Materials And Methods: For this study, 108 non-duplicate A. Read More

    Renal function of MDR-TB patients treated with kanamycin regimens or concomitantly with antiretroviral agents.
    Int J Tuberc Lung Dis 2017 Dec;21(12):1245-1250
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
    Setting: To compare renal insufficiency among multidrug-resistant tuberculosis (MDR-TB) patients treated with kanamycin (KM) based regimens and those treated concomitantly with tenofovir disoproxil fumarate (TDF) or other antiretroviral therapy (ART) regimens in Namibia.

    Design: Retrospective review of the treatment records and laboratory tests of patients initiated on MDR-TB treatment (January-December 2014). The glomerular filtration rates (eGFR) estimated pre- and post-treatment were compared using the analysis of variance test. Read More

    Neutrophils and the S100A9 protein critically regulate granuloma formation.
    Blood Adv 2016 Dec 14;1(3):184-192. Epub 2016 Dec 14.
    Laboratory of Cell Regulation, Institute for Virus Research, and.
    Macrophages have the potential to undergo cellular transformation into epithelioid cells, and their concentric accumulation in tissues results in the development of granulomas. Although epithelioid cells are an essential and dominant component of granulomas, other cell types have also been detected, which may contribute to the establishment of well-organized granulomas, as observed in human granulomatous diseases. We herein demonstrated that neutrophils may mediate these functions. Read More

    Xanthelasma palpebrarum - a brief review.
    Clin Cosmet Investig Dermatol 2018 18;11:1-5. Epub 2017 Dec 18.
    Department of Dermatology, Venereology and Leprosy, Pramukhswami Medical College, Gujarat, India.
    Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial reticular dermis. Read More

    Natural history of Mycobacterium fortuitum pulmonary infection presenting with migratory infiltrates: a case report with microbiological analysis.
    BMC Infect Dis 2018 Jan 2;18(1). Epub 2018 Jan 2.
    Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
    Background: Presence of Mycobacterium fortuitum in respiratory tracts usually indicates mere colonization or transient infection, whereas true pulmonary infection occurs in patients with gastroesophageal disease. However, little is known about the diagnostic indications for true M. fortuitum pulmonary infection and the natural history of the disease. Read More

    A novel vitamin D receptor polymorphism associated with leprosy.
    J Dermatol Sci 2017 Dec 23. Epub 2017 Dec 23.
    Federal University of Uberlandia, Institute of Genetics and Biochemistry, Laboratory of Nanobiotechnology, MG, Brazil; University of California Davis, Dept. of Medical Microbiology and Immunology, Davis, CA, USA. Electronic address:

    Retrospective active case finding in Cambodia: An innovative approach to leprosy control in a low-endemic country.
    Acta Trop 2017 Dec 28;180:26-32. Epub 2017 Dec 28.
    Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:
    Currently, leprosy control relies on the clinical diagnosis of leprosy and the subsequent administration of multidrug therapy (MDT). However, many health workers are not familiar with the cardinal signs of leprosy, particularly in low-endemic settings including Cambodia. In response, a new approach to early diagnosis was developed in the country, namely retrospective active case finding (RACF) through small mobile teams. Read More

    A Pathway-Based Association Analysis Identified FMNL1-MAP3K14 as Susceptibility Genes for Leprosy.
    Exp Dermatol 2017 Dec 28. Epub 2017 Dec 28.
    Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, 250000, China.
    The nuclear transcription factor-κB (NF-κB) plays a pivotal role in controlling both innate and adaptive immunity and regulates the expressions of many immunological mediators. Abundant evidences have showed that the importance of NF-κB pathway in the host immune responses against Mycobacterium leprae in the development of leprosy. However, no particular association study between leprosy and NF-κB pathway related gene polymorphisms was reported. Read More

    Humanitarian quarantine in practice: medicine, religion and leprosy in New Caledonia.
    Anthropol Med 2017 Dec;24(3):301-318
    a Department of Archaeology and History , University of Latrobe , Melbourne , Australia.
    Medicine and religion worked in close synchronisation during the leprosy outbreak of New Caledonia (1890-1950). Once isolation of leprosy-affected people became mandatory doctors and missionaries came together to promote a particular form of medical practice that tied charitable zeal with cutting-edge medical research, developing a sophisticated set of medical practices that catered for the soul as well as the body. Such practices went hand-in-hand with ideas developed by doctors in the earlier stages of the epidemic about the way in which the disease had entered the Kanak (local Melanesian) population. Read More

    Swan Neck Deformity Mimicking Claw Hand Caused by Arthritis in Leprosy.
    Case Rep Dermatol 2017 Sep-Dec;9(3):231-235. Epub 2017 Nov 14.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
    Swan neck deformity is a hyperextension of the proximal interphalangeal (PIP) joints and flexion of the distal interphalangeal (DIP) joints. Claw hand is a hyperextension of the metacarpal joints and flexion of the PIP joints, accompanied by reduced motor strength. A 23-year-old female, who was released from leprosy treatment, presented with a bend of the second to fifth fingers of both hands. Read More

    Hyaluronic Acid in Dermatology.
    Skinmed 2017 1;15(6):441-448. Epub 2017 Dec 1.
    Department of Dermatology, STD and Leprosy, Government Medical College and Associated SMHS Hospital Srinagar, Jammu and Kashmir, India;
    Hyaluronic acid (HA) is a major component of the extracellular matrix of the skin and plays an important role in the metabolism of the dermis. It has a key position in wound healing and tissue repair processes owing to its ability to maintain a humid environment favorable to healing and the stimulation of growth factors, cellular constituents, and the migration of various cells essential for healing. This review aims to describe briefly the physical, chemical, and biologic properties of HA, together with some details of the dermatologic indications of this unique molecule. Read More

    Incidence of mycobacterial disorders in Indian adult male service population followed for over two decades.
    J Infect Public Health 2017 Dec 23. Epub 2017 Dec 23.
    Department of Pediatrics, Army Hospital (Research & Referral), Delhi 110010, India. Electronic address:
    Background: The comprehensive epidemiology of mycobacterial disorders is scarce from our country. The incidence of Tuberculosis (TB) and Leprosy in a cohort of military personnel followed for a long duration was evaluated in this study.

    Methods: The data for this descriptive epidemiologic study was derived from the electronic medical records (EMR) data of the service personnel enrolled between 1990 and 2015. Read More

    Evaluation of 16S rRNA qPCR for detection of Mycobacterium leprae DNA in nasal secretion and skin biopsy samples from multibacillary and paucibacillary leprosy cases.
    Pathog Glob Health 2017 Dec 26:1-7. Epub 2017 Dec 26.
    f Department of Community Health, Medicine School , Federal University of Ceará , Fortaleza , Brazil.
    Mycobacterium leprae bacilli are mainly transmitted by the dissemination of nasal aerosols from multibacillary (MB) patients to susceptible individuals through inhalation. The upper respiratory tract represents the main entry and exit routes of M. leprae. Read More

    Disfiguring facial lesions and loss of sensation.
    JAAPA 2018 Jan;31(1):27-29
    Marleen Hundemer and Claire Ramsay Wan practice in family medicine with Cambridge (Mass.) Health Alliance. Ms. Hundemer also practices in emergency medicine in Boston, Mass. The authors have disclosed no potential conflicts of interest, financial or otherwise.
    Hansen disease (leprosy) continues to be prevalent in some regions of Africa, Asia, and South America, and each year 100 to 300 cases are reported in the United States, especially in immigrants and patients exposed to armadillos. Treatment depends on patient presentation. Hansen disease remains highly stigmatized, though it is now clear that it is not readily transmitted through casual physical contact. Read More

    Elevated Pentraxin-3 Concentrations in Patients With Leprosy: Potential Biomarker of Erythema Nodosum Leprosum.
    J Infect Dis 2017 Dec;216(12):1635-1643
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
    Background: Leprosy, the leading infectious cause of disability worldwide, remains a major public health challenge in the most severely affected countries despite the sharp decline in new cases in recent years. The search for biomarkers is essential to achieve a better understanding of the molecular and cellular mechanisms underlying the disease.

    Methods: Pentraxin-3 (PTX3) analyses of sera from 87 leprosy patients with or without reactions were conducted via enzyme-linked immunosorbent assay. Read More

    Analysis of the epidemiological situation of leprosy in an endemic area in Brazil: spatial distribution in the periods 2001 - 2003 and 2010 - 2012.
    Rev Bras Epidemiol 2017 Oct-Dec;20(4):702-713
    Instituto de Pesquisa Econômica Aplicada - Brasília (DF), Brasil.
    Introduction: In Brazil, the spatial distribution of leprosy is heterogeneous. Areas with high transmission of the disease remain in the North, Center-west and Northeast. Areas with high transmission of the disease remain in the Northern, Central-Western and Northeastern regions of the country. Read More

    Pattern of dermatoses in two groups of admitted psychiatric patients: a cross-sectional study from a tertiary care hospital in Kashmir.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):89-95
    Postgraduate department of Psychiatry, Institute of Mental Health and Neurosciences (IMHANS), Government Medical College Srinagar, University of Kashmir, Srinagar, India.
    Background: Various specific and non-specific dermatological manifestations can be found in patients with psychiatric ailments. Most studies in this regard have been conducted on an outpatient basis and not much work has been done on patients admitted with psychiatric diseases.

    Methods: This cross-sectional hospital-based study involved two groups of admitted psychiatric patients over a period of 1 year, involving 100 patients in each group. Read More

    Cutaneous Cysts with Nail Dystrophy in a Young Female: A Classical Association.
    Indian J Dermatol 2017 Nov-Dec;62(6):661-664
    Department of Dermatology, Venereology and Leprosy, School of Tropical Medicine, Kolkata, West Bengal, India.
    Pachyonychia Congenita (PC) refers to a group of autosomal dominant disorders with variable clinical presentations. While nail dystrophy and plantar keratoderma are the most consistent features in all the variants, a myriad of other manifestations has been observed. This report highlights a case of young female presenting with multiple asymptomatic cutaneous cysts associated with plantar kearatoderma and nail dystrophy. Read More

    Electrophysiological Study of Nerves in Type-II Reaction in Leprosy.
    Indian J Dermatol 2017 Nov-Dec;62(6):644-648
    Department of Medicine, BRD Medical College, Gorakhpur, Uttar Pradesh, India.
    Background: Leprosy is a chronic granulomatous infection primarily affecting the peripheral nervous system, skin and reticuloendothelial system. Cutaneous nerves are severely affected in lepra reaction and this leads to morbidity.

    Objective: To study electrophysiological pattern of different nerves involved in Type-II reactions in leprosy. Read More

    Use of Fine Needle Aspirate from Peripheral Nerves of Pure-neural Leprosy for Cytology and Polymerase Chain Reaction to Confirm the Diagnosis: A Follow-up Study of 4 Years.
    Indian J Dermatol 2017 Nov-Dec;62(6):635-643
    Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.
    Background: Pure neural leprosy (PNL) still remains a diagnostic challenge because of the absence of sine qua non skin lesions of leprosy and a confirmatory diagnostic method. The authors had earlier described a simple yet objective technique of combining fine needle aspiration cytology (FNAC) coupled with a multiplex polymerase chain reaction (PCR) in a pilot study, wherein the technique showed promise of a reliable diagnostic tool. In the pursuit of further evidence, the authors carried out a 4-year study with PNL cases to find the efficacy and reliability of the said method in a larger sample size. Read More

    Inpatient Mortality Resulting from Dermatological Disorders at a Tertiary Care Center in Eastern India: A Record-based Observational Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):626-629
    Department of Dermatology, Venereology, and Leprosy, Medical College, Kolkata, West Bengal, India.
    Background: Contrary to popular perception, several dermatological conditions may be associated with lethal outcome in the absence of timely intervention or due to complications.

    Aims: The aim was to estimate the number of deaths and analyze their causes due to skin disorders at a tertiary level inpatient dermatology ward.

    Materials And Methods: We conducted a retrospective, record-based observational study involving 538 patients spanning over 4 years (2013-2016) at our dermatology indoor setup. Read More

    Clinical, Histopathological Characteristics and Immunohistochemical Findings in Lichen Planus Pigmentosus.
    Indian J Dermatol 2017 Nov-Dec;62(6):612-617
    Department of Dermatology, Venereology and Leprosy, Father Muller Medical College and Hospital, Kankanady, Mangalore, Karnataka, India.
    Background: Lichen planus pigmentosus (LPP), a rare variant of lichen planus, is reported in various ethnic groups, more often from the Indian subcontinent and the Middle East.

    Aims: Although the condition is encountered quite often by dermatologists of this region, the data on the clinical, pathological, and immunohistochemical (IHC) aspects of LPP are limited. This prospective study is aimed towards filling this lacuna. Read More

    Clinico-epidemiological Study of Congenital Ichthyosis in a Tertiary Care Center of Eastern India.
    Indian J Dermatol 2017 Nov-Dec;62(6):606-611
    Department of Dermatology, Venereology and Leprosy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.
    Background: Congenital ichthyoses comprises various specific genetic diseases and can range from mild to very severe presentation. Furthermore, these may be associated with various syndromes. There is scanty data regarding the demographic profile and clinical features of patients with congenital ichthyosis in India. Read More

    A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction?
    BMC Dermatol 2017 Dec 20;17(1):16. Epub 2017 Dec 20.
    Clinical and Experimental Allergy and Immunology Laboratory LIM-56, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis of the underlying disorder is therefore crucial to institute the appropriate therapy. Read More

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