29,918 results match your criteria Leprosy

Intravenous pulsed corticosteroids for leprosy neuritis: Logical or irrational?

Indian J Dermatol Venereol Leprol 2022 May 9:1-2. Epub 2022 May 9.

Department of Dermatology, Shalby Hospital, SAS Nagar, Punjab, India.

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Hansen's disease masquerading as rheumatoid arthritis: A case report.

Clin Case Rep 2022 May 12;10(5):e05822. Epub 2022 May 12.

Department of Internal Medicine Mount Sinai Hospital Chicago Illinois USA.

Hansen's disease, a chronic granulomatous disease, classically has cutaneous and neurological manifestations. Musculoskeletal manifestation of the disease is underappreciated. This case report conveys that musculoskeletal manifestation of the disease should not be missed, as sometimes it is the only presenting symptom, to avoid delay in correct diagnosis and treatment. Read More

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Recurrent palmar erythematous plaques with pseudovesicles: Sweet's syndrome affecting palms only.

Arun Inamadar

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Department of Dermatology, Venereology & Leprosy, Shri BM Patil Medical College, Vijayapur, Karnataka, India

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Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study.

Acta Biotheor 2022 May 19;70(2):16. Epub 2022 May 19.

Sri Sathya Sai Institute of Higher Learning - SSSIHL, Anantapur, India.

The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. Read More

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Effect of "Mehrpishegan" web-based support group on depression, anxiety, and stress among elderly informal caregivers: a protocol for a randomized-controlled trial.

Trials 2022 May 17;23(1):413. Epub 2022 May 17.

Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: Elderly population in low- and middle-income countries is rapidly growing, which indicates an increase in the number of dependent people needing long-term care. Caring for the elderly is difficult and stressful and threatens physical and mental health of informal caregivers. We aim to design a web-based support group and assess its effectiveness on depression, anxiety, and stress among elderly informal caregivers. Read More

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Co-occurrence of linear scleroderma en coup de sabre and segmental vitiligo on the face.

BMJ Case Rep 2022 May 16;15(5). Epub 2022 May 16.

Dermatology, Venereology and Leprosy, Kasturba Medical College Mangalore, Mangalore, India.

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Reorienting to mild and borderline intellectual disability: an appeal from south Asia.

Lancet Psychiatry 2022 06;9(6):e26

CBM India Trust, Delhi, India; The Leprosy Mission Trust India, Delhi 110001, India. Electronic address:

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Potassium permanganate: A 'Desert Island drug' in Dermatology.

Clin Exp Dermatol 2022 May 15. Epub 2022 May 15.

Department of Dermatology,Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, India.

Potassium permanganate (KMnO4) is an over the-counter available astringent with oxidising and antiseptic property used by the dermatologists since ages. It is often used as compresses and baths for various exudative dermatoses. Its advantages include lower cost, good healing rate and reduced allergenic potential. Read More

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Laboratory perspectives for Leprosy: Diagnostic, prognostic and predictive tools.

Indian J Pathol Microbiol 2022 May;65(Supplement):S300-S309

Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Gomti Nagar, Lucknow, Uttar Pradesh, India.

The diagnosis of leprosy poses several challenges. The bacillary load, serology, and tissue response are determined by the host immune status, which make individual tests unsuitable across the spectrum. The sensitivity of tests for identifying paucibacillary cases remains limited, on the other hand, many tests lack specificity in differentiating contacts from diseased cases. Read More

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Neglected tropical diseases in Australia: a narrative review.

Med J Aust 2022 May 12. Epub 2022 May 12.

Australian National University, Canberra, ACT.

•Neglected tropical diseases (NTDs) represent a threat to the health, wellbeing and economic prosperity of billions of people worldwide, often causing serious disease or death. •Commonly considered diseases of low and middle-income nations, the presence of NTDs in high income countries such as Australia is often overlooked. •Seven of the 20 recognised NTDs are endemic in Australia: scabies, soil-transmitted helminths and strongyloidiasis, echinococcosis, Buruli ulcer, leprosy, trachoma, and snakebite envenoming. Read More

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Arginase 1 is a marker of protection against illness in contacts of leprosy patients.

Sci Rep 2022 May 12;12(1):7850. Epub 2022 May 12.

Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21040-360, Brazil.

Leprosy household contacts are generally more prone to develop the disease compared to the general population. Previous studies have demonstrated that genes related to the alternative activation (M2) profile in macrophages are associated with the increased bacillary load in multibacillary leprosy patients (MB), and that contacts of MB patients have a higher risk of contracting the disease. In addition, positive serological responses to PGL-1 or LID-1 are associated with a higher risk of disease. Read More

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Computational assessment of phytomolecules as putative inhibitors of CTP synthase PyrG.

J Biomol Struct Dyn 2022 May 12:1-14. Epub 2022 May 12.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.

Genome evolution of (Mtb) produces new strains resistant to various pre-existing anti-tubercular drugs. Hence, there is an urgent need to explore potent compounds with the most negligible side effects and effective Mtb inhibition. Mtb PyrG (CTP synthase) is a crucial enzyme for the conversion of the uridine triphosphate (UTP) into cytidine triphosphate (CTP) and is essential for the growth of Mtb. Read More

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Can Leprosy Reaction States Mimic Symptoms of Fibromyalgia? A Cross-Sectional Analytical Study.

Front Med (Lausanne) 2022 25;9:870584. Epub 2022 Apr 25.

Programa de Pós-Graduação em Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasilia, Brazil.

Leprosy causes significant pain in affected patients, especially those experiencing reactional states. Fibromyalgia is characterized by widespread pain and is often accompanied by fatigue. Confusion between the clinical manifestations of fibromyalgia and those of leprosy reactions is possible at the primary care level, the first contact with the health system in most cases. Read More

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Implementation of genetic screening test to reduce the incidence of dapsone hypersensitivity syndrome among patients with leprosy in Papua, Indonesia: a study protocol.

BMJ Open 2022 May 11;12(5):e057173. Epub 2022 May 11.

Papua Provincial Health Office, Jayapura, Indonesia.

Introduction: The mainstay of leprosy treatment is multidrug treatment (MDT), which contains rifampicin, dapsone and clofazimine. The occurrence of dapsone hypersensitivity syndrome (DHS), a sudden, potentially fatal and traumatic adverse reaction due to dapsone, may affect treatment adherence and may result in fatality if untreated. Before MDT administration, screening for in patients with leprosy can potentially reduce DHS risk. Read More

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Dapsone is an anticatalysis for Alzheimer's disease exacerbation.

iScience 2022 May 20;25(5):104274. Epub 2022 Apr 20.

College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.

Brain inflammation generally accelerates neurodegeneration. Alzheimer's disease (AD) triggers an innate immune response by activating a cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway. Our study investigated patients with leprosy and AD. Read More

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Potential Cross-Transmission of Mycobacterium abscessus among Non-Cystic Fibrosis Patients at a Tertiary Hospital in Japan.

Microbiol Spectr 2022 May 10:e0009722. Epub 2022 May 10.

Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.

(M. abscessus) is a highly antimicrobial-resistant pathogen that causes refractory pulmonary disease. Recently, the possibility of M. Read More

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Visibly enlarged feeder nerve in Hansen disease.

Neurol India 2022 Mar-Apr;70(2):837-838

Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Pondicherry, India.

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Complete Chromosomal Genome Sequence of Mycobacterium sp. Strain IWGMT90018-18076.

Microbiol Resour Announc 2022 May 9:e0007822. Epub 2022 May 9.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

We have isolated a strain that we believe is identical to strain IWGMT90018-an unidentified nontuberculous mycobacterium (NTM) species published in 1981-and named it IWGMT90018-18076. Here, we report its complete chromosomal genome sequence. This study will help us understand the diversity and pathogenicity of NTM. Read More

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Effectiveness of Topical 0.5% Ivermectin Shampoo in the Treatment of Pediculosis Capitis among School-going Female Children.

Int J Trichology 2022 Mar-Apr;14(2):55-59. Epub 2022 Apr 4.

Department of Dermatology, Venereology and Leprosy and Community Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.

Background: Pediculosis is a common ectoparasitic infestation in children. There are different treatment modalities that have been used in the treatment of pediculosis capitis from time immemorial, each with their own shortcomings. Increasing emergence of resistance to permethrin has led to the lookout for newer alternatives. Read More

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A Young Female With Borderline Lepromatous Leprosy and Tuberculous Lymphadenitis: A Rare Coinfection.

Cureus 2022 Apr 6;14(4):e23892. Epub 2022 Apr 6.

Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.

In Bangladesh, tuberculosis and leprosy are endemic mycobacterial diseases; however, co-infection is rarely seen. Our patient had a high-grade fever, symmetrical polyarthritis, polymorphous erythematous lesions, widespread lymphadenopathy, peripheral neuropathy, bilaterally thickened ulnar nerves, and claw hands. A lymph node biopsy revealed tuberculosis having acid-fast bacilli with caseating epithelioid histiocytic granuloma. Read More

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Does endovascular repair of post-traumatic thoracic vascular injury of the subclavian/axillary arteries followed by brachial plexus injury improve outcome?

Indian J Thorac Cardiovasc Surg 2022 May 3;38(3):294-299. Epub 2021 Dec 3.

Department of Hand and Leprosy Reconstructive Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu 632004 India.

Traumatic injuries to the axillary artery or subclavian artery along with a brachial plexus injury are infrequent. Although the traditional management has been conservative because of robust collaterals, the functional improvement of the limb depends on the degree of brachial plexus injury and on the revascularization status. We report three cases of endovascular repair post-traumatic axillo-subclavian artery injuries followed by brachial plexus injury with good functional outcomes. Read More

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Molecular identification of species isolated from candiduria and its risk factors in neonates and children.

Curr Med Mycol 2021 Sep;7(3):9-12

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background And Purpose: The present study was performed to raise attention on the frequency of spp. and evaluation of risk factors of candiduria in neonates and children.

Materials And Methods: In total, 60 urine samples were collected from the suspected neonates and children. Read More

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September 2021

Genomics of Ancient Pathogens: First Advances and Prospects.

Biochemistry (Mosc) 2022 Mar;87(3):242-258

Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119333, Russia.

Paleogenomics is one of the urgent and promising areas of interdisciplinary research in the today's world science. New genomic methods of ancient DNA (aDNA) analysis, such as next generation sequencing (NGS) technologies, make it possible not only to obtain detailed genetic information about historical and prehistoric human populations, but also to study individual microbial and viral pathogens and microbiomes from different ancient and historical objects. Studies of aDNA of pathogens by reconstructing their genomes have so far yielded complete sequences of the ancient pathogens that played significant role in the history of the world: Yersinia pestis (plague), Variola virus (smallpox), Vibrio cholerae (cholera), HBV (hepatitis B virus), as well as the equally important endemic human infectious agents: Mycobacterium tuberculosis (tuberculosis), Mycobacterium leprae (leprosy), and Treponema pallidum (syphilis). Read More

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Feasibility and acceptability of using the novel urine-based FujiLAM test to detect tuberculosis: A multi-country mixed-methods study.

J Clin Tuberc Other Mycobact Dis 2022 May 25;27:100316. Epub 2022 Apr 25.

Epicentre Paris, France.

Background: The novel urine-based FujiLAM test identifies tuberculosis in HIV-positive patients but may be challenging to use at point-of-care (POC).

Objectives: We assessed the feasibility and acceptability of using the FujiLAM test at point of care in outpatient settings.

Methods: We conducted a mixed methods study in four outpatient settings in Kenya, Mozambique, South Africa, and Uganda between November 2020 and September 2021. Read More

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Proportion and trend of primary resistance among Multidrug resistant Tuberculosis patients in Ethiopia.

J Clin Tuberc Other Mycobact Dis 2022 May 25;27:100315. Epub 2022 Apr 25.

Armauer Hansen Research Institute, Jimma Road, ALERT Compound, P.O.Box 1005, Addis Ababa, Ethiopia.

Background: Evidence based information on the proportion & trend of primary resistance among multidrug resistance (MDR) TB patients is important for designing effective strategies in the control of the disease.

Methods: A retrospective record review of 348 MDR/RR-TB patients treated at All African Leprosy Rehabilitation & Training (ALERT) Center from January 2014- December 2018. Categorical variables were compared using Chi-square/Fisher exact test as appropriate. Read More

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Grade 2 disability among leprosy patients: A pilot study from an endemic area of Central India.

J Family Med Prim Care 2022 Apr 18;11(4):1416-1420. Epub 2022 Mar 18.

Department of Dermatology, Venereology and Leprosy, BRLSABV Medical College, Pendri, Rajnandgaon, Chhattisgarh, India.

Background And Aim: Deformities and disabilities in leprosy lead to significant morbidity to the individual and financial burden to the family. As the prevalence of leprosy is higher in central India, this study was conducted to know the burden of deformity and disability among leprosy patients in central India and the factors associated with it.

Materials And Methods: This was a hospital-based, cross-sectional study, conducted on 50 new or on treatment or released from treatment leprosy patients, attending the Dermatology OPD of a tertiary care institute in Central India. Read More

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Identification of shared loci associated with both Crohn's disease and leprosy in east Asians.

Hum Mol Genet 2022 May 5. Epub 2022 May 5.

Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.

Genome-wide association studies (GWAS) of Crohn's disease (CD) in European and leprosy in Chinese population have shown that CD and leprosy share genetic risk loci. As these shared loci were identified through cross-comparisons across different ethnic populations, we hypothesized that meta-analysis of GWAS on CD and leprosy in East Asian populations would increase power to identify additional shared loci. We performed a cross-disease meta-analysis of GWAS data from CD (1621 cases and 4419 controls) and leprosy (2901 cases 3801 controls) followed by replication in additional datasets comprising 738 CD cases and 488 controls and 842 leprosy cases and 925 controls. Read More

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Global epidemiology of leprosy from 2010 to 2020: A systematic review and meta-analysis of the proportion of sex, type, grade 2 deformity and age.

Pathog Glob Health 2022 May 4:1-10. Epub 2022 May 4.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Dingjiaqiao, Nanjing, China.

The objectives of this study were to explore global epidemiological characteristics of leprosy, and to provide reference for the construction of prevention strategies for leprosy. Computer retrieval of the study on the epidemiology of leprosy from 2010 to 2020 in Web of Science, PubMed, and SCOPUS databases were summarized. The included studies were assessed for the quality of the AHRQ; the proportions of the study indices were meta-analyzed with Stata 16. Read More

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