28,198 results match your criteria Leprosy


Temporal trends and spatial distribution of leprosy-related mortality in the state of Tocantins, Brazil, 2000-2015.

Epidemiol Serv Saude 2020 1;29(3):e2018336. Epub 2020 Jun 1.

Fundação Escola de Saúde Pública de Palmas, Palmas, TO, Brasil.

Objective to describe temporal trends and spatial distribution patterns of leprosy-related deaths in the state of Tocantins, Brazil, 2000-2015. Methods this study was based on Mortality Information System (SIM) data; mortality coefficient temporal trend analysis was performed using joinpoint regression and descriptive spatial analysis, taking the state's 139 municipalities as geographic units of analysis. Results 201 leprosy-related deaths were identified in Tocantins; average mortality coefficient was 0. Read More

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http://dx.doi.org/10.5123/s1679-49742020000300003DOI Listing

The interference of polypharmacy and the importance of clinical pharmacy advice in the treatment of leprosy: a case-control study.

Rev Soc Bras Med Trop 2020 1;53:e20200114. Epub 2020 Jun 1.

Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.

Introduction: Although supervised doses are essential for reducing leprosy treatment failure, the impact of specific drug interactions has rarely been assessed. This study aimed to estimate the risk of leprosy treatment suspension in patients receiving polypharmacy. METHODS We performed this case-control study in which the primary outcome was defined as the need to discontinue multibacillary leprosy treatment for at least one supervised dose, and the main risk factor was the detection of polypharmacy. Read More

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http://dx.doi.org/10.1590/0037-8682-0114-2020DOI Listing

Primary care quality and its effects on leprosy monitoring indicators.

Rev Bras Enferm 2020 1;73(4):e20190038. Epub 2020 Jun 1.

Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Objectives: to evaluate the quality of primary care in leprosy control actions, to correlate effects on monitoring indicators.

Methods: a cross-sectional study, conducted in Belo Horizonte, from July to September 2014. Interviews with 408 professionals were conducted through the application of a tool that assesses attributes of primary care in leprosy control actions, and monitoring indicators were calculated. Read More

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http://dx.doi.org/10.1590/0034-7167-2019-0038DOI Listing

Visual Dermatology: Epidermodysplasia Verruciformis.

J Cutan Med Surg 2020 Jun 1:1203475420931775. Epub 2020 Jun 1.

72924 Department of Dermatology, Venereology, and Leprosy, R.G.Kar Medical College, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1177/1203475420931775DOI Listing

Visual Dermatology: Pellagroid Dermatitis.

J Cutan Med Surg 2020 Jun 1:1203475420931771. Epub 2020 Jun 1.

72924 Department of Dermatology, Venereology, and Leprosy, R.G.Kar Medical College, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1177/1203475420931771DOI Listing

Dermoscopy of Localized Darier's Disease in Fitzpatrick Type IV Skin.

Indian Dermatol Online J 2020 Mar-Apr;11(2):298-300. Epub 2020 Mar 9.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_412_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247640PMC

The Curious Case of an Elusive Solitary Plaque.

Indian Dermatol Online J 2020 Mar-Apr;11(2):288-290. Epub 2020 Mar 9.

Department of Dermatology, Venereology, and Leprosy, Dr. KN Barua Institute of Dermatological Sciences, Guwahati, Assam, India.

A 60-year-old male patient presented with a solitary pink plaque over the inner aspect of the left forearm of 4 years duration. The lesion was persistent and unresponsive to treatment. A skin biopsy was done with differential diagnosis of lupus vulgaris, tuberculoid leprosy, and granuloma annulare. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_457_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247637PMC

Epidermolytic Nevus: An Instance of Mosaic Epidermolytic Ichthyosis.

Indian Dermatol Online J 2020 Mar-Apr;11(2):272-273. Epub 2020 Mar 9.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_254_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247631PMC

An Unusual Presentation of Post kala-azar Dermal Leishmaniasis.

Indian Dermatol Online J 2020 Mar-Apr;11(2):269-271. Epub 2020 Mar 9.

Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_338_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247655PMC

A Case of Familial Trichomegaly with Synophrys in Association with Loose Anagen Syndrome.

Indian Dermatol Online J 2020 Mar-Apr;11(2):263-265. Epub 2020 Mar 9.

Department of Pathology, Dr. Ram Manohar Lohia and Post Graduate Institute of Medical Education and Research, New Delhi, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_16_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247634PMC

Rubinstein-Taybi Syndrome: A Rare Case Report.

Indian Dermatol Online J 2020 Mar-Apr;11(2):258-260. Epub 2020 Mar 9.

Department of Dermatology, Venereology and Leprosy, Government Medical College, Nagpur, Maharashtra, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_108_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247649PMC

Bardet-Biedl Syndrome with Café-au-Lait Macule: Association or Coincidence?

Indian Dermatol Online J 2020 Mar-Apr;11(2):246-249. Epub 2020 Mar 9.

Department of Dermatology, Venereology and Leprosy, Government Medical College, Nagpur, Maharashtra, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_106_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247639PMC

Washout Period for Pregnancy Post Isotretinoin Therapy.

Indian Dermatol Online J 2020 Mar-Apr;11(2):239-242. Epub 2020 Mar 9.

Dermatology, Venereology and Leprosy, The Venkat Center for Skin and Plastic Surgery - Post Graduate Training Center (Affiliated to RGUHS), Subbanna Garden, Bengaluru, Karnataka, India.

Introduction And Background: Isotretinoin is an oral medication used for the treatment of severe acne unresponsive to other medications. This drug is teratogenic and should be prescribed with appropriate caution in selected group of patients. The washout period for pregnancy post isotrenoin therapy has always been a topic of controversy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_101_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247620PMC

Nail Changes in Leprosy: An Observational Study of 125 Patients.

Indian Dermatol Online J 2020 Mar-Apr;11(2):195-201. Epub 2020 Mar 9.

Department of Skin and VD, SBH Govt. Medical College, Dhule, Maharashtra, India.

Introduction: Leprosy is a disease primarily affecting skin and nerve. Nail involvement, although indirect, is observed in several patients. This is a study to determine the pattern of nail changes in leprosy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_172_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247625PMC

Spectrum of Cutaneous Adverse Drug Reactions to Anti-tubercular Drugs and Safe Therapy after Re-challenge - A Retrospective Study.

Indian Dermatol Online J 2020 Mar-Apr;11(2):177-181. Epub 2020 Mar 9.

Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Background: Tuberculosis (TB) is a major global health problem and leading cause of death. Anti-tubercular therapy (ATT) can lead to various adverse effects including cutaneous reactions. Re-challenge remains the only option to restart the safe therapy with limited number of most efficient primary ATT drugs. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_133_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247648PMC

Intra-Operative Dermoscopy in Assessment of Melanonychia and as a Guide for Biopsy.

Indian Dermatol Online J 2020 Mar-Apr;11(2):171-176. Epub 2020 Mar 9.

Department of Pathology, ESI-PGIMSR Hospital, Basaidarapur, Delhi, India.

Background And Aims: Melanonychia can be a manifestation of benign or malignant pathology and often poses a diagnostic challenge on clinical examination. Even with distinguishing dermoscopic features (nail plate), it can be quite difficult to determine the nature of pigmentation as complete assessment of nail bed and matrix is still not possible. Intraoperative dermoscopy (IOD) can serve as a useful tool to appreciate the bed and matrix changes. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_94_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247626PMC

Molecular Identification and Quantification of Species Isolated from Pityriasis Versicolor.

Indian Dermatol Online J 2020 Mar-Apr;11(2):167-170. Epub 2020 Mar 9.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Pityriasis versicolor (PV) is the most common chronic superficial infection of the stratum corneum, reported in 40-60% of the tropical population. After the description of the new species, only a few studies have been conducted from India.

Aims: Molecular identification, quantification of species implicated with PV and correlation to its clinical presentation. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_142_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247642PMC

Dermoscopic Pigment Network: Characteristics in Non-melanocytic Disorders.

Indian Dermatol Online J 2020 Mar-Apr;11(2):146-153. Epub 2020 Mar 9.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Brown-black pigment network is the hallmark dermoscopic feature of melanocytic lesions. Several non-melanocytic disorders also exhibit a pigment network as one of their main or useful dermoscopic diagnostic features. This article presents a compilation of such disorders to the readers describing their essential dermoscopic features with an emphasis on the characteristics of the pigment network exhibited by them. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_246_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247650PMC

Update on Management of Morphea (Localized Scleroderma) in Children.

Indian Dermatol Online J 2020 Mar-Apr;11(2):135-145. Epub 2020 Mar 9.

Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.

Juvenile localized scleroderma (morphea) is the predominant scleroderma in childhood which affects the skin and may extend to the underlying fascia, muscle, joints and bone. The assessment of activity and damage can be done with a validated instrument like LoSCAT. Disease classified as "low severity" which includes superficial plaque morphea can be treated with topical mid potent- potent steroids, tacrolimus, calcipotriol or imiquimod in combination with phototherapy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_284_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247622PMC

Population Genomics of Reveals a New Genotype in Madagascar and the Comoros.

Front Microbiol 2020 11;11:711. Epub 2020 May 11.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic legacies are still present in Madagascar and other islands of the Indian Ocean. The close relationship between human migration and the introduction and spread of infectious diseases, a well-documented phenomenon, is particularly evident for the causative agent of leprosy, . Read More

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http://dx.doi.org/10.3389/fmicb.2020.00711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233131PMC

Clofazimine: an old drug for never-ending diseases.

Future Microbiol 2020 Jun 1. Epub 2020 Jun 1.

StopTB Italia Onlus, Milan, Italy.

Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases. CFZ has several advantages such as a favorable pharmacokinetic profile, dose-dependent side effects as well as low price. In this narrative review, we have assessed the clinical development of CFZ, starting from the potential mechanism of actions, to the spectrum of side effects and potential drug-drug interactions, highlighting its current place in therapy and future possible use in leprosy, nontuberculous mycobacterial diseases and drug-resistant tuberculosis. Read More

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http://dx.doi.org/10.2217/fmb-2019-0231DOI Listing
June 2020
4.275 Impact Factor

Late leprosy reaction presenting as erythema multiforme-like erythema nodosum leprosum with underlying rifampicin resistance and its potential implications.

Int J Mycobacteriol 2020 Apr-Jun;9(2):226-228

Research Scientist, Stanley Browne Laboratory, The Leprosy Mission Community Hospital, New Delhi, India.

Erythema multiforme (EM)-like erythema nodosum leprosum (ENL) is a rare atypical presentation, and its late appearance after the completion of multidrug therapy (MDT) is unusual. We describe the case of a lepromatous leprosy patient who after the completion of MDT presented to us with late EM-like ENL and was found to be resistant to rifampicin. We discuss the implications of this finding and the potential role of resistant bacilli in causing reactions with atypical presentations. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_26_20DOI Listing

Long-term ulcerations caused by .

Int J Mycobacteriol 2020 Apr-Jun;9(2):223-225

Dermatology Unit, Department of Health Sciences (DISSAL), University of Genoa, San Martino Policlinic Hospital, IRCCS, Genoa, Italy.

Patients with leprosy rarely present ulcerated lesions that can appear during reactional states like Lucio's phenomenon (LP), as in our case. LP is a rare complication of multibacillary leprosy due to massive bacilli invasion of endothelial cells causing a thrombotic syndrome. The initial macular lesion is purpuric followed by multiple infiltrated papules and nodules, some of them ulcerated, associated to loss of sensation on lower limbs. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_40_20DOI Listing

Tuberculous verrucosa cutis with a sporotrichoid distribution.

Int J Mycobacteriol 2020 Apr-Jun;9(2):220-222

Department of Pathology, Venereology and Leprosy, All India Institute of Medical Sciences, Rishikesh, Uttrakhand, India.

Tuberculosis verrucosa cutis (TBVC) is a common paucibacillary form of cutaneous tuberculosis caused by exogenous reinfection in previously sensitized individuals. The typical morphology is usually observed as a single verrucous plaque with inflammatory borders mostly on the hands, knees, ankle, and buttocks; however, several atypical morphologies of the lesions have also been described. TBVC occurring in sporotrichoid pattern is relatively rare. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_19_20DOI Listing

Clinicobacteriological evaluation of leprosy patients with 1-5 skin lesions.

Int J Mycobacteriol 2020 Apr-Jun;9(2):209-211

Department of Dermatology, Era's Lucknow Medical College and Hospital, Lucknow Era University, Lucknow, Uttar Pradesh, India.

Background: Mycobacterium leprae is a noncultivable mycobacteria, and diagnosis of the disease is based on its clinical and histopathological characteristics and finding the bacteria in skin scrapings and in biopsies taken from the patients. The aim of this study was to shed light on the clinical classification (based on the number of skin lesions) used extensively in the field where patients classified as paucibacillary (PB) were positive on skin smears and histopathology leading to treatment failure and drug resistance.

Methods: In this study, we enrolled untreated 62 leprosy patients with 1-5 skin lesions and did a detailed bacterio-histopathological analysis by slit-skin smears (SSSs) and histopathology. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_7_20DOI Listing

Pityriasis lichenoides et varioliformis acuta following measles rubella vaccine.

Indian J Dermatol Venereol Leprol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Venereology and Leprosy, JSS Medical College, Mysore, Karnataka, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_48_18DOI Listing

Are we witnessing a paradigm shift in leprosy: Two atypical presentations of histoid hansen's disease.

Int J Mycobacteriol 2020 Jan-Mar;9(1):103-106

Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India.

Hansen's disease is a chronic infectious granulomatous disease with varied clinical presentation. In the postelimination era, histoid Hansen's disease is an important emerging lepromatous subset known to mimic varied dermatoses, thereby making clinical diagnosis difficult and often delayed. We report two cases of histoid Hansen's disease bereft of clinical cardinal signs of leprosy. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_187_19DOI Listing

Evaluation of the intracellular accumulation of fluoroquinolones in mycobacteria by fluorometric assays.

Int J Mycobacteriol 2020 Jan-Mar;9(1):34-38

Department of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar Pradesh, India.

Background: Fluoroquinolones (FQs) are being used as second-line agents in the treatment of tuberculosis caused by multidrug-resistant strains. Ofloxacin (OFX) is being tried as a part of modified multidrug therapy regimens for leprosy. A preliminary study was carried out to evaluate the accumulation of FQs - OFX, levofloxacin (LFX), norfloxacin (NFX), and ciprofloxacin (CIF) in Mycobacterium smegmatis. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_194_19DOI Listing

Dominant marker (inter-simple sequence repeat-polymerase chain reaction) versus codominant marker (RLEP-polymerase chain reaction) for laboratory diagnosis of leprosy: A comparative evaluation.

Int J Mycobacteriol 2020 Jan-Mar;9(1):18-23

Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.

Background: Leprosy is a contagious disease and was eliminated globally in 2002. Since then, new cases were continuously detected from different parts of the world. Untreated leprosy cases shed millions of bacteria and are the main cause of dissemination of the disease. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_190_19DOI Listing

Leprosy in the Colombian island of Providencia

Biomedica 2020 05 1;40(Supl. 1):26-31. Epub 2020 May 1.

Oficina de Docencia e Investigación, Hospital Universitario Centro Dermatológico Federico Lleras Acosta, Bogotá, D.C., Colombia; Facultad de Medicina, Universidad de la Sabana, Chía, Colombia.

San Andrés and Providencia are Colombian islands in the Caribbean Sea. San Andrés has 68,283 inhabitants and has registered cases of leprosy in immigrants from continental Colombia. Providencia has 5,037 inhabitants and historically health programs did not have records of the disease, but in 2009 two cases of multibacillary histoid leprosy were confirmed and, subsequently, another two, which represents a prevalence of 8 cases per 10,000 inhabitants and places the island as a hyperendemic site for leprosy. Read More

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http://dx.doi.org/10.7705/biomedica.4974DOI Listing

Persistent Infection Versus Type 2 Immunological Reaction in Lepromatous Leprosy.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620927884

University of Texas Medical Branch, Galveston, TX, USA.

The distinction between persistent infection and immunologic reactions in leprosy is often difficult but critically important since their management is different. We present the case of a 51-year-old Vietnamese female who presented in 2015 with areas of erythema and skin infiltration on face and chest, as well as edema on her hands and feet. Skin biopsy was consistent with lepromatous leprosy. Read More

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http://dx.doi.org/10.1177/2324709620927884DOI Listing

"Therapeutic Needling-A Novel & Simple Technique to Treat Non healing Trophic Ulcers in Leprosy".

Dermatol Ther 2020 May 27:e13691. Epub 2020 May 27.

Dermatology, Venereology & Leprosy, Deptt.of Dermatology, All India Institute of Medical Sciences, Gorakhpur, India.

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http://dx.doi.org/10.1111/dth.13691DOI Listing

Ultra-sensitive detection of M. leprae: DNA extraction and PCR assays.

PLoS Negl Trop Dis 2020 May 26;14(5):e0008325. Epub 2020 May 26.

Laboratório de Hanseníase, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.

Leprosy urgently needs a precise and early diagnostic tool. The sensitivity of the direct (bacilli staining, Mycobacterium leprae DNA) and indirect (antibody levels, T cell assays) diagnostics methods vary based on the clinical form. Recently, PCR-based M. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008325DOI Listing

Painful Skin Nodules in Nephrotic Syndrome.

Indian J Pediatr 2020 May 26. Epub 2020 May 26.

Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

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http://dx.doi.org/10.1007/s12098-020-03343-7DOI Listing

Disability progression among leprosy patients released from treatment: a survival analysis.

Infect Dis Poverty 2020 May 24;9(1):53. Epub 2020 May 24.

Health Sciences Graduation Program, Federal University of Mato Grosso (UFMT), Cuiabá, Brazil.

Background: Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT, Brazil in the period 2000 to 2017.

Methods: A retrospective cohort study and survival analysis were performed in the hyperendemic municipality of Cáceres in the state of Mato Grosso. Read More

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http://dx.doi.org/10.1186/s40249-020-00669-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245886PMC

Blaschkoid Angioma Serpiginosum: A Clinico-Dermoscopic Diagnosis.

J Pediatr 2020 May 20. Epub 2020 May 20.

Department of Dermatology, Venereology, and Leprosy; R. G. Kar Medical College, Kolkata; West Bengal, India.

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http://dx.doi.org/10.1016/j.jpeds.2020.05.021DOI Listing

Urticaria Pigmentosa.

J Pediatr 2020 May 20. Epub 2020 May 20.

Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, India.

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http://dx.doi.org/10.1016/j.jpeds.2020.03.053DOI Listing

Management of Leprosy Patients in the Era of COVID19.

Dermatol Ther 2020 May 22:e13631. Epub 2020 May 22.

Associate Professor, Department of Dermatology, Venereology & Leprosy, AIIMS, Gorakhpur, India.

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http://dx.doi.org/10.1111/dth.13631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267076PMC

The role of thymus and activation-regulated chemokine as a marker of severity of atopic dermatitis.

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.jaad.2020.05.052DOI Listing

Computational investigation of phytomolecules as resuscitation-promoting factor B (RpfB) inhibitors for clinical suppression of Mycobacterium tuberculosis dormancy reactivation.

Infect Genet Evol 2020 May 8;83:104356. Epub 2020 May 8.

ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, India. Electronic address:

Among the various strategies of curbing tuberculosis, suppression of Mycobacterium tuberculosis (Mtb) is a primary goal of the WHO to stop its infection, which is further strengthened by the presence of a massive reservoir of latently infected individuals. Several efforts have been made to explore potential candidates, including drug-repurposing, phytomolecules evaluation, and de novo designs. Compared to other strategies, investigation of phytomolecules with known experimental evidence represents a highly cost-effective and less time-consuming approach. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104356DOI Listing
May 2020
3.015 Impact Factor

Immune Complex-Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity.

J Immunol 2020 May 20. Epub 2020 May 20.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742;

To maintain homeostasis, macrophages must be capable of assuming either an inflammatory or an anti-inflammatory phenotype. To better understand the latter, we stimulated human macrophages in vitro with TLR ligands in the presence of high-density immune complexes (IC). This combination of stimuli resulted in a broad suppression of inflammatory mediators and an upregulation of molecules involved in tissue remodeling and angiogenesis. Read More

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http://dx.doi.org/10.4049/jimmunol.1901382DOI Listing

Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.

PLoS Negl Trop Dis 2020 May 20;14(5):e0008247. Epub 2020 May 20.

Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.

Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these associations need to be confirmed through independent replication studies in different ethnicities. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008247DOI Listing

Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study.

J Cosmet Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Oxidative damage to melanocytes, resulting from an imbalance between the damaging oxidative pathways and the protective anti-oxidants likely plays a pathogenic role in vitiligo.

Aim: To evaluate three parameters related to the oxidative stress (OS) pathway namely malondialdehyde (MDA), a marker of oxidative damage, and superoxide dismutase (SOD) and reduced glutathione (rGSH) (both antioxidants) in patients with active and stable vitiligo with either localized or generalized disease.

Patients/methods: Sixty clinically diagnosed vitiligo patients were categorized into generalized (n = 30) or localized vitiligo (n = 30) and were further sub-grouped according to their disease activity into active and stable groups. Read More

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http://dx.doi.org/10.1111/jocd.13499DOI Listing

Xpert Ultra assay on stool to diagnose pulmonary tuberculosis in children.

Clin Infect Dis 2020 May 18. Epub 2020 May 18.

Programme on Emerging Infections, Infectious Diseases Division, icddr,b, Mohakhali, Dhaka, Bangladesh.

Background: World Health Organization recommends Xpert MTB/RIF Ultra assay for diagnosing pulmonary tuberculosis (PTB) in children. Though stool is a potential alternative to respiratory specimens among children, the diagnostic performance of Xpert Ultra on stool is unknown. Thus, we assessed the diagnostic performance of Xpert Ultra on stool to diagnose PTB in children. Read More

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http://dx.doi.org/10.1093/cid/ciaa583DOI Listing
May 2020
8.886 Impact Factor

Family-based genome-wide association study of leprosy in Vietnam.

PLoS Pathog 2020 May 18;16(5):e1008565. Epub 2020 May 18.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.

Leprosy is a chronic infectious disease of the skin and peripheral nerves with a strong genetic predisposition. Recent genome-wide approaches have identified numerous common variants associated with leprosy, almost all in the Chinese population. We conducted the first family-based genome-wide association study of leprosy in 622 affected offspring from Vietnam, followed by replication in an independent sample of 1181 leprosy cases and 668 controls of the same ethnic origin. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008565DOI Listing

Impact of common skin diseases on children in rural Cote d'ivoire with leprosy and buruli ulcer co-endemicity: A mixed methods study.

PLoS Negl Trop Dis 2020 May 18;14(5):e0008291. Epub 2020 May 18.

International Foundation for Dermatology, London, United Kingdom.

Background: Skin-related neglected tropical diseases (skin NTDs) occur against a background of a very high prevalence of common skin diseases in sub-Saharan Africa. In this study, we examined the knowledge, attitude and practices (KAP) and the impact of common skin diseases in children living in a leprosy and Buruli ulcer (BU) co-endemic district in a west African country of Côte d'Ivoire, in order to help inform disease control efforts for skin NTDs.

Methods And Principle Findings: Fourteen focus group discussions (FGDs) with schoolchildren, 5 FGDs with parents of a child affected with skin disease(s), and 27 in-depth semi-structured interviews with key personnel were conducted. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008291DOI Listing

Visual Dermatology: Waardenburg Syndrome Type II.

J Cutan Med Surg 2020 May/Jun;24(3):305

72924 Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1177/1203475420902048DOI Listing

Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality.

J Cosmet Dermatol 2020 May 17. Epub 2020 May 17.

Center for Research & Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Skin boosting with small particles of hyaluronic acid (HA) is a new method of skin rejuvenation.

Aim: Here, we aim to evaluate the efficacy and safety of booster injections of noncross-linked HA in improving the facial skin quality.

Methods: A total of 20 men and women age 40. Read More

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http://dx.doi.org/10.1111/jocd.13493DOI Listing

Bilateral nasal nodules with supraciliary madarosis.

Clin Exp Dermatol 2020 May 18. Epub 2020 May 18.

Indushree Skin Clinic, Lucknow, India.

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http://dx.doi.org/10.1111/ced.14231DOI Listing