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    Comparison of Enzyme-Linked Immunosorbent Assay Using Either Natural Octyl Disaccharide-Leprosy IDRI Diagnostic or Phenolic Glycolipid-I Antigens for the Detection of Leprosy Patients in Colombia.
    Am J Trop Med Hyg 2017 Nov 6. Epub 2017 Nov 6.
    Instituto Colombiano de Medicina Tropical-Universidad CES, Sabaneta, Antioquia, Colombia.
    Leprosy is a chronic infectious disease with a broad spectrum of manifestations. Delays in attaining correct diagnosis permit progressive peripheral nerve damage that can produce irreversible disabilities. Tests detecting antigen-specific antibodies can aid the diagnostic process and potentially detect patients earlier. Read More

    Hansen's Disease and Rheumatoid Arthritis Crossover of Clinical Symptoms: A Case Series of 18 Patients in the United States.
    Am J Trop Med Hyg 2017 Oct 23. Epub 2017 Oct 23.
    National Hansen's Disease Program, Baton Rouge, Louisiana.
    Hansen's Disease (HD) is a rare, chronic granulomatous infection of the skin and peripheral nerves caused by the noncultivable organism Mycobacterium leprae. Arthritis is the third most common symptom of HD. Subjects with both confirmed HD on skin biopsy and chronic arthritis were identified at the National Hansen's Disease Program (NHDP). Read More

    Two Cases of Lepromatous Leprosy from Exposure to Armadillos in Florida.
    Skinmed 2017 1;15(5):391-393. Epub 2017 Oct 1.
    Department of Dermatopathology, James A. Haley Veterans Hospital, Tampa, FL.
    The first patient was a 41-year-old white man who was referred to the dermatology clinic with a 2-year history of numerous erythematous, hypoesthetic, poorly demarcated papules and plaques present on the trunk, buttocks, and bilateral upper and lower extremities (Figures 1 and 2). The lesions had initially begun as localized erythematous plaques on the right flank, and were diagnosed and treated as cellulitis and allergic contact dermatitis by primary care on separate occasions, with no resolution and continued gradual but persistent spread. Read More

    Patent landscape of neglected tropical diseases: an analysis of worldwide patent families.
    Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.
    Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
    Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More

    Clinical significance of interferon-γ neutralizing autoantibodies against disseminated nontuberculous mycobacterial disease.
    Clin Infect Dis 2017 Nov 8. Epub 2017 Nov 8.
    Department of Respiratory Medicine and Infectious Disease, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
    Background: Interferon-γ neutralizing autoantibodies (nIFNγ-autoAb) are reported in patients with disseminated nontuberculous mycobacteria (NTM) infection and may function by increasing the infection risk. Notwithstanding, the prevalence of nIFNγ-autoAb as well as the clinical presentation, diagnosis, and natural history, of disseminated NTM infection in these patients is poorly understood.

    Methods: In this retrospective observational study, data and sera for 331 Japanese subjects with mycobacterial infection were collected and analyzed. Read More

    Insignificant Correlation between Thyroid Hormone and Antithyroid Peroxidase Antibodies in Alopecia Areata Patients in Northern Rajasthan.
    Int J Trichology 2017 Oct-Dec;9(4):149-153
    Department of Dermatology, STDs and Leprosy, SMS Medical College, Jaipur, Rajasthan, India.
    Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0. Read More

    Using Patient-Pathway Analysis to Inform a Differentiated Program Response to Tuberculosis: The Case of Kenya.
    J Infect Dis 2017 Nov;216(suppl_7):S714-S723
    Linksbridge, Seattle, Washington.
    Background: A recent tuberculosis prevalence survey in Kenya found that the country is home to nearly twice as many patients with tuberculosis as previously estimated. Kenya has prioritized identifying and treating the unnotified or missing cases of tuberculosis. This requires a better understanding of patient care seeking and system weaknesses. Read More

    Increasing Access to Tuberculosis Services in Ethiopia: Findings From a Patient-Pathway Analysis.
    J Infect Dis 2017 Nov;216(suppl_7):S696-S701
    Bill and Melinda Gates Foundation.
    Background: In Ethiopia, extensive scale-up of the availability of health extension workers (HEWs) at the community level has been credited with increased identification and referral of patients with presumptive tuberculosis, which has contributed to increased tuberculosis case notification and better treatment outcomes. However, nearly 30% of Ethiopia's estimated 191000 patients with tuberculosis remained unnotified in 2015. A better understanding of patient care-seeking practices may inform future government action to reach all patients with tuberculosis. Read More

    IL-37 and leprosy: A novel cytokine involved in the host response to Mycobacterium leprae infection.
    Cytokine 2017 Oct 27. Epub 2017 Oct 27.
    Tropical Medicine Center, Federal University of Pará, Belém, Pará, Brazil; Center of Health and Biological Sciences, State University of Pará, Belém, Pará, Brazil. Electronic address:
    Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae, in which the clinical outcome depends on the pattern of the host immune response. Because it is a spectral disease, leprosy is a good model for studying the immunology of the pathogen-host relationship. Although previous studies have characterized the participation of cytokine profiles such as Th1, Th2, Th7, Treg, Th9, and Th22 responses in leprosy, the role of new cytokines such as IL-37 have not yet been described for the spectral model of the disease. Read More

    Drop-out from the tuberculosis contact investigation cascade in a routine public health setting in urban Uganda: A prospective, multi-center study.
    PLoS One 2017 6;12(11):e0187145. Epub 2017 Nov 6.
    Uganda Tuberculosis Implementation Research Consortium, Makerere University, Kampala, Uganda.
    Setting: Seven public tuberculosis (TB) units in Kampala, Uganda, where Uganda's national TB program recently introduced household contact investigation, as recommended by 2012 guidelines from WHO.

    Objective: To apply a cascade analysis to implementation of household contact investigation in a programmatic setting.

    Design: Prospective, multi-center observational study. Read More

    Skin Surface pH in Acne Vulgaris: Insights from an Observational Study and Review of the Literature.
    J Clin Aesthet Dermatol 2017 Jul 1;10(7):33-39. Epub 2017 Jul 1.
    Drs. Prakash, P. Bhargava, Tiwari and Majumdar are with the Department of Dermatology, Venereology and Leprosy, Sawai Man Singh Medical College and Attached Hospitals, Jaipur, Rajasthan, India.
    OBJECTIVE: Recurrent and chronic course of acne vulgaris, despite effect-proven therapies, point to an underfocused aspect in its pathogenesis and management. This study aims to assess in subjects with and without acne, the skin surface pH, a parameter that cumulatively represents functioning of various units of skin, including the barrier. METHODS: A total of 200 patients with acne and 200 age- and sex-matched controls were included. Read More

    Analysis of CTLA-4+49A/G gene polymorphism in cases with leprosy of Azerbaijan, Northwest Iran.
    Infect Genet Evol 2017 Nov 2. Epub 2017 Nov 2.
    Immunology Unit, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
    Leprosy, which is developed by the obligate intracellular Mycobacterium leprae (ML); has different manifestations, associated with the host immune responses. The protective immune response against ML includes T-cell-mediated immunity. The CTLA-4 has a great impact as a negative regulator of the immune response and maintenance of peripheral tolerance. Read More

    Hodgkin's lymphoma arising in a case of mycosis fungoides: An unusual association.
    Indian J Dermatol Venereol Leprol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pathology, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    Mycosis fungoides is a cutaneous T-cell lymphoma with a high risk for developing secondary malignancies, especially B-cell lymphoproliferative disorders. About 40 cases of Hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. We report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. Read More

    Molecular detection of multi drug resistant Mycobacterium leprae from Indian leprosy patients.
    J Glob Antimicrob Resist 2017 Oct 30. Epub 2017 Oct 30.
    TLM Kothara Community Hospital Kothara, Maharashtra-444 805.
    Objective: Emergence of multi drug resistant (MDR) organism for any infectious disease is a public health concern. Global efforts to control leprosy by intensive chemotherapy have led to a significant decrease in the number of registered patients. Currently recommended control measures for treating leprosy with MDT was designed to prevent the spread of dapsone resistant strains of Mycobacterium leprae. Read More

    Leprosy Presenting with Iridocyclitis: A Diagnostic Dilemma.
    J Ophthalmic Vis Res 2017 Oct-Dec;12(4):437-439
    Department of Pathology, Uttar Pradesh University of Medical Sciences (U.P.U.M.S.), Saifai, Etawah, India.
    Purpose: To report a case of lepromatous iridocyclitis that posed a diagnostic challenge.

    Case Report: A 50-yeasr-old male developed profound loss of vision in the right eye, while he was in the hospital with septicemia presenting with fever, dysuria, and abdominal swelling. He also developed erythema nodosum on the legs. Read More

    The safety of influenza vaccine in clinically cured leprosy patients in China.
    Hum Vaccin Immunother 2017 Oct 31. Epub 2017 Oct 31.
    a Department of Leprosy , Wuhan Institute of Dermatology and Venereology , Wuhan , China.
    Background Leprosy is an infectious disease caused by the bacterium Mycobacterium leprae. Influenza vaccine is an important influenza prevention strategy and the preparations used display good safety and tolerability profiles. But the safety of applying influenza vaccine on the clinical cured leprosy patients is unclear. Read More

    Ethnopharmacological and Phytopharmaceutical Evaluation of Prosopis cineraria: An overview and future prospects.
    Curr Drug Metab 2017 Oct 31. Epub 2017 Oct 31.
    Central Arid Zone Research Institute (ICAR Institute), Jodhpur, Rajasthan. India.
    Prosopis cineraria (L.) Druce ('khejri') is an important tree that occurs worldwide in arid regions. It has been mentioned in the Indian Ayurvedic system of medicines as having several clinical properties. Read More

    Neutrophil extracellular traps in patients with pulmonary tuberculosis.
    Respir Res 2017 Oct 30;18(1):181. Epub 2017 Oct 30.
    Centre for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105, AZ, Amsterdam, The Netherlands.
    Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. Read More

    Peripheral Nerve Stimulation for Painful Mononeuropathy Secondary to Leprosy: A 12-Month Follow-Up Study.
    Neuromodulation 2017 Oct 29. Epub 2017 Oct 29.
    Department of Endocrinology, University Hospital of Brasília, Brasilia, Brazil.
    Objective: Leprosy affects approximately 10-15 million patients worldwide and remains a relevant public health issue. Chronic pain secondary to leprosy is a primary cause of morbidity, and its treatment remains a challenge. We evaluated the feasibility and safety of peripheral nerve stimulation (PNS) for painful mononeuropathy secondary to leprosy that is refractory to pharmacological therapy and surgical intervention (decompression). Read More

    Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial.
    Dermatol Ther 2017 Oct 30. Epub 2017 Oct 30.
    Center for Research & Training in Skin Disease & Leprosy, Tehran University of Medical Science, Tehran, Iran.
    The effect of thermotherapy in the treatment of skin warts in comparison to cryotherapy, as the standard conventional method, has remained uncertain. This study aimed to assess the clinical efficacy and safety of thermotherapy and cryotherapy in removing skin warts. This randomized controlled trial was conducted on 52 patients aged 18 years and over with ≤ 10 skin warts. Read More

    Dermatological moulage collections in the Nordic countries.
    J Eur Acad Dermatol Venereol 2017 Oct 28. Epub 2017 Oct 28.
    Medical Museion, University of Copenhagen, Denmark.
    Background: The art of producing and acquiring dermatological wax models, moulages, flourished all over Europe in the beginning of the twentieth century, whereas very little is known about the existence of moulage collections in the Nordic countries.

    Objective: The aim of this paper is to elucidate the presence, the origin, the production place, the use and the condition of dermatological moulage collections in the Nordic countries.

    Methods: In each Nordic country, an extensive survey was undertaken during spring 2016. Read More

    Phylogeographic and phylogenetic analysis for Tripterygium species delimitation.
    Ecol Evol 2017 Oct 22;7(20):8612-8623. Epub 2017 Sep 22.
    School of Traditional Chinese MedicineCapital Medical UniversityBeijingChina.
    Tripterygium wilfordii (Celastraceae) is a traditional Chinese medicine; and the dried root and rhizome constitute the main officinal parts. Tripterygium wilfordii has been identified as a potential candidate for the treatment of systemic lupus erythematosus, rheumatoid arthritis, nephritis, asthma, leprosy, and cancer. The phylogenetic relationships within the Tripterygium genus are ambiguous; thus, our aim is to clarify the relationships within this genus using phylogeographic and phylogenetic analyses. Read More

    Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study.
    Mol Biol Res Commun 2017 Sep;6(3):113-122
    National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
    The emergence of drug resistance in leprosy is a major hurdle in leprosy elimination programme. Although the problem of drug resistance is presently not acute, it is important that we collect data more systematically and monitor the trend carefully so that effective measures to combat this problem can be developed. The present study aimed at the explication of cross resistance of rifabutin and rifapentine to rifampicin which would be helpful to programme managers for implementing rifabutin or rifapentine in replace of rifampicin. Read More

    Histomorphometric approach to differentiate skin lesions of tuberculoid leprosy from sarcoidosis.
    J Cutan Pathol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Pathology, University of Campinas (Unicamp), Brazil.
    Background: More than 200,000 new cases of leprosy are detected worldwide annually. Physicians commonly have difficulty in differentiating tuberculoid form of leprosy (TL) from sarcoidosis' cutaneous manifestation.

    Methods: Skin biopsies of 33 patients with TL and 24 with sarcoidosis were reviewed on hematoxylin and eosin and Gomori stained sections, in order to find reliable criteria for distinguishing one disease from another. Read More

    Modelling of cerebral tuberculosis in BALB/c mice using clinical strain from patients with CNS tuberculosis infection.
    Indian J Med Res 2017 Jun;145(6):833-839
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, India.
    Background & Objectives: Central nervous system (CNS) infection caused by Mycobacterium tuberculosis (MTB) is the most severe form of extrapulmonary tuberculosis (EPTB) due to a high level of mortality and morbidity. Limited studies are available on CNS-TB animal model development. The present study describes the development of a murine model of CNS-TB using a clinical strain (C3) isolated from the cerebrospinal fluid (CSF) of CNS-TB patients. Read More

    Q-switched Nd: YAG laser alone or with modified Jessner chemical peeling for treatment of mixed melasma in dark skin types: A comparative clinical, histopathological, and immunohistochemical study.
    J Cosmet Dermatol 2017 Oct 22. Epub 2017 Oct 22.
    Dermatology and leprosy Hospital, Al-Minya, Egypt.
    Backgrounds: Treatment of mixed melasma remains challenging. Promising results have been achieved with low-fluence 1064-nm Q-switched Nd-YAG laser; however, multiple sessions are necessary with occurrence of complications especially in dark skin types. So, combination methods may be recommended. Read More

    Dapsone as a potential treatment option for Henoch-Schönlein Purpura (HSP).
    Med Hypotheses 2017 Oct 17;108:42-45. Epub 2017 Jul 17.
    Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Henoch-Schönlein Purpura (HSP, IgA vasculitis) is an immunoglobulin A (IgA) mediated disorder characterized by systemic vasculitis with variable presentation, frequently affecting the skin, mucous membrane, joints, kidneys, and rarely lungs and the central nervous system. Interestingly, enhanced production of interleukin-8 (IL-8) levels are found during active disease and increased levels have been reported in supernatants from human umbilical venous endothelial cells after stimulation with sera from patients affected by HSP. While corticosteroid therapy is currently the recommended treatment for HSP, dapsone, an anti-leprosy agent, has also recently been suggested to have therapeutic efficacy due to its ability to suppress IL-8. Read More

    Diffuse Multibacillary Leprosy of Lucio and Latapí with Lucio's Phenomenon, Peru.
    Emerg Infect Dis 2017 11;23(11):1929-1930
    Diffuse multibacillary leprosy of Lucio and Latapí is mainly reported in Mexico and Central America. We report a case in a 65-year-old man in Peru. He also had Lucio's phenomenon, characterized by vascular thrombosis and invasion of blood vessel walls by leprosy bacilli, causing extensive skin ulcers. Read More

    Autochthonous Leprosy without Armadillo Exposure, Eastern United States.
    Emerg Infect Dis 2017 11;23(11):1928
    Autochthonous leprosy has been reported in New York City, where there are no wild armadillos. Recent autochthonous cases also have been reported in Georgia and Florida and blamed on armadillos, including cases with no known armadillo exposure. International migration needs to be considered as a cause of autochthonous leprosy. Read More

    Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas.
    Emerg Infect Dis 2017 11;23(11):1864-1866
    We report Mycobacterium lepromatosis infection in a US-born person with an extensive international travel history. Clinical symptoms, histopathology, and management are similar to those of infections caused by M. leprae. Read More

    Insights from the Genome Sequence of Mycobacterium lepraemurium: Massive Gene Decay and Reductive Evolution.
    MBio 2017 Oct 17;8(5). Epub 2017 Oct 17.
    Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    Mycobacterium lepraemurium is the causative agent of murine leprosy, a chronic, granulomatous disease similar to human leprosy. Due to the similar clinical manifestations of human and murine leprosy and the difficulty of growing both bacilli axenically, Mycobacterium leprae and M. lepraemurium were once thought to be closely related, although it was later suggested that M. Read More

    The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation.
    J Invest Dermatol 2017 Oct 14. Epub 2017 Oct 14.
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:
    Clofazimine is a weakly basic, FDA-approved antibiotic recommended by the World Health Organization to treat leprosy and multi-drug-resistant tuberculosis. Upon prolonged treatment, clofazimine extensively bioaccumulates and precipitates throughout the organism, forming crystal-like drug inclusions (CLDIs). Because of the drug's red color, it is widely believed that clofazimine bioaccumulation results in skin pigmentation, its most common side effect. Read More

    Effectiveness of rifampicin chemoprophylaxis in preventing leprosy in patient contacts: a systematic review of quantitative and qualitative evidence.
    JBI Database System Rev Implement Rep 2017 Oct;15(10):2555-2584
    1The University of Cuiabá, and Graduate Program, Federal University of Mato Grosso/School of Nursing, Mato Grosso, Brazil 2School of Nursing, University of São Paulo, São Paulo, Brazil 3Mato Grosso State University, Mato Grosso, Brazil 4The Brazilian Centre for Evidence-based Healthcare: a Joanna Briggs Institute Centre of Excellence.
    Background: Individuals in contact with patients who have leprosy have an increased risk of disease exposure, which reinforces the need for chemoprophylactic measures, such as the use of rifampicin.

    Objectives: The objective of the review was to synthesize the best available evidence regarding the effectiveness of rifampicin chemoprophylaxis for contacts with patients with leprosy, and to synthesize the best available evidence on the experience and acceptability of rifampicin chemoprophylaxis as reported by the contacts and health professionals involved in the treatment of leprosy or Hansen's disease.

    Inclusion Criteria Types Of Participants: In the quantitative component, individuals in contact with leprosy patients were included. Read More

    Biological evaluation of novel curcumin-pyrazole-mannich derivative active against drug-resistant Mycobacterium tuberculosis.
    Future Microbiol 2017 Nov 16;12:1349-1362. Epub 2017 Oct 16.
    Division of Microbiology, CSIR-Central Drug Research Institute, Sector 10, Janakipuram Extension, Sitapur Road, Lucknow - 226031, Uttar Pradesh, India.
    Aim: Our objective was to identify a more potent curcumin derivative with specific activity against Mycobacterium tuberculosis.

    Materials & Methods:  A total of 21 curcumin derivatives were synthesized and detailed bio-evaluation was carried out including determination of static/cidality, synergy with front-line antituberculosis drugs and determination of efficacy in the murine model of M. tuberculosis infection. Read More

    Leprosy Associated with Atypical Cutaneous Leishmaniasis in Nicaragua and Honduras.
    Am J Trop Med Hyg 2017 Oct;97(4):1103-1110
    University College London, London, United Kingdom.
    In Central America, few cases of leprosy have been reported, but the disease may be unrecognized. Diagnosis is based on clinical criteria and histology. Preliminary field work in Nicaragua and Honduras found patients, including many children, with skin lesions clinically suggestive of atypical cutaneous leishmaniasis or indeterminate leprosy. Read More

    Clinico-pathological features of erythema nodosum leprosum: A case-control study at ALERT hospital, Ethiopia.
    PLoS Negl Trop Dis 2017 Oct 13;11(10):e0006011. Epub 2017 Oct 13.
    London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.
    Background: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. Read More

    A strong TB programme embedded in a developing primary healthcare system is a lose-lose situation: insights from patient and community perspectives in Cambodia.
    Health Policy Plan 2017 Oct;32(suppl_2):i32-i42
    Saw Swee Hock School of Public Health, National University of Singapore, 0808 Rivergate, 97 Robertson Quay, Singapore 238257, Singapore.
    As exemplified by the situation in Cambodia, disease specific (vertical) health programmes are often favoured when the health system is fragile. The potential of such an approach to impede strengthening of primary healthcare services has been studied from a health systems perspective in terms of access and quality of care. In this bottom-up, qualitative study we investigate patient and community member experiences of health services when a strong tuberculosis (TB) programme is embedded into a relatively underutilized primary healthcare system. Read More

    Assessing the Ovarian Accessory Glands to Determine the Parity of Phlebotomus papatasi, Vector of Zoonotic Cutaneous Leishmaniasis, under Laboratory Condition.
    J Arthropod Borne Dis 2017 Mar 14;11(1):161-165. Epub 2017 Mar 14.
    Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Zoonotic cutaneous leishmaniasis (ZCL) is a neglected tropical disease prevailed in many rural areas of 17 out of 31 provinces in Iran. The main vector of the disease is Phlebotomus papatasi and the causative agent is Leishmania major in ZCL foci of Iran. In the current study we investigated the validity of accessory glands secretions as an indicator to recognize parous from nulliparous Ph. Read More

    Defining the research agenda to measure and reduce tuberculosis stigmas.
    Int J Tuberc Lung Dis 2017 Nov;21(11):87-96
    KNCV Tuberculosis Foundation, The Hague, The Netherlands.
    Crucial to finding and treating the 4 million tuberculosis (TB) patients currently missed by national TB programmes, TB stigma is receiving well-deserved and long-delayed attention at the global level. However, the ability to measure and evaluate the success of TB stigma-reduction efforts is limited by the need for additional tools. At a 2016 TB stigma-measurement meeting held in The Hague, The Netherlands, stigma experts discussed and proposed a research agenda around four themes: 1) drivers: what are the main drivers and domains of TB stigma(s)?; 2) consequences: how consequential are TB stigmas and how are negative impacts most felt?; 3) burden: what is the global prevalence and distribution of TB stigma(s) and what explains any variation? 4): intervention: what can be done to reduce the extent and impact of TB stigma(s)? Each theme was further subdivided into research topics to be addressed to move the agenda forward. Read More

    Tuberculosis among older adults in Zambia: burden and characteristics among a neglected group.
    BMC Public Health 2017 Oct 12;17(1):804. Epub 2017 Oct 12.
    School of Public Health, University of Sydney, Sydney, Australia.
    Background: The 2010 Global Burden of Disease estimates show that 57% of all TB deaths globally occurred among adults older than 50 years of age. Few studies document the TB burden among older adults in Southern Africa. We focused on adults older than 55 years to assess the relative TB burden and associated demographic factors. Read More

    Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary.
    PLoS One 2017 12;12(10):e0185966. Epub 2017 Oct 12.
    Department of Biological Anthropology, Institute of Biology, Faculty of Science, Eötvös Loránd University, Budapest, Hungary.
    At the Abony-Turjányos dűlő site, located in Central Hungary, a rescue excavation was carried out. More than 400 features were excavated and dated to the Protoboleráz horizon, at the beginning of the Late Copper Age in the Carpathian Basin, between 3780-3650 cal BC. Besides the domestic and economic units, there were two special areas, with nine-nine pits that differed from the other archaeological features of the site. Read More

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