Search our Database of Scientific Publications and Authors

I’m looking for a

    25830 results match your criteria Leprosy

    1 OF 517

    Long-pulsed Nd: YAG Laser and Intense Pulse Light-755 nm for Idiopathic Facial Hirsutism: A Comparative Study.
    J Cutan Aesthet Surg 2017 Jan-Mar;10(1):40-44
    Department of Dermatology, Venereology and Leprosy, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
    Background: Hirsutism means excessive terminal hair growth in a female in male pattern distribution. Perception of hirsutism is subjective. Permanent laser hair reduction is a slow process taking many sessions and tracking of improvement parameters is tedious. Read More

    The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.
    Cell Rep 2017 May;19(7):1394-1405
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
    HLA-B(∗)46:01 was formed by an intergenic mini-conversion, between HLA-B(∗)15:01 and HLA-C(∗)01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B(∗)46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B(∗)46:01 has a low-diversity peptidome that is distinct from those of its parents. Read More

    Expression of interleukin-1β and interleukin-6 in leprosy reactions in patients with human immunodeficiency virus coinfection.
    Acta Trop 2017 May 13;172:213-216. Epub 2017 May 13.
    Tropical Medicine Center, Federal do Para University, Belem-Pa, Brazil; Center of Health and Biological Sciences, State University of Para, Belem-Pa, Brazil. Electronic address:
    Previous studies suggest that coinfection of leprosy and human immunodeficiency virus (HIV) does not decrease the frequency and intensity of leprosy reactions. However, the immunological aspects of leprosy reactions in coinfected patients remain obscure, with a limited number of studies showing contradictory results. Observational study using tissue samples collected during leprosy reactions from 15 patients coinfected with leprosy and HIV and from 15 patients with leprosy alone. Read More

    In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin.
    PLoS One 2017 15;12(5):e0177815. Epub 2017 May 15.
    Department of Clinical Immunology, Colleges of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
    Mycobacterium leprae (M. leprae) infection causes nerve damage and the condition worsens often during and long after treatment. Clearance of bacterial antigens including lipoarabinomannan (LAM) during and after treatment in leprosy patients is slow. Read More

    Clinical and molecular characterization of a 13-year-old Indian boy with cutis laxa type 2B: Identification of two novel PYCR1 mutations by amplicon-based semiconductor exome sequencing.
    J Dermatol Sci 2017 Apr 29. Epub 2017 Apr 29.
    Division of Biology and Genetics, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy; Department of Dermatology, Venereology & Leprosy, Sri B. M. Patil Medical College, Hospital & Research Center, BLDE University, Vijayapur, Karnataka, India; Division of Biology and Genetics, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy; Department of Dermatology, Venereology & Leprosy, Sri B. M. Patil Medical College, Hospital & Research Center, BLDE University, Vijayapur, Karnataka, India; Division of Biology and Genetics, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy; Department of Dermatology, Venereology & Leprosy, Sri B. M. Patil Medical College, Hospital & Research Center, BLDE University, Vijayapur, Karnataka, India; Division of Biology and Genetics, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy. Electronic address:

    Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties.
    Biologics 2017 2;11:55-63. Epub 2017 May 2.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    This article reviews briefly the making of an immunoprophylactic-cum-immunotherapeutic vaccine against leprosy. The vaccine is based on cultivable, heat-killed atypical mycobacteria, whose gene sequence is now known. It has been named Mycobacterium indicus pranii. Read More

    Leprosy and women.
    Int J Womens Dermatol 2016 Dec 25;2(4):117-121. Epub 2016 Oct 25.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India.
    Leprosy has an impact on the physical, social, and psychological health of affected people. Women in developing countries seek health care late for any health-related issues. Leprosy, a disease known for its stigma, adds further to these facts. Read More

    Impact of leishmaniasis in women: a practical review with an update on my ISD-supported initiative to combat leishmaniasis in Yemen (ELYP).
    Int J Womens Dermatol 2016 Sep 16;2(3):93-101. Epub 2016 Jun 16.
    Regional Leishmaniasis Control Center, Sana'a, Yemen.
    Stigma is synonymous with leishmaniasis, an endemic deadly flesh-eating disease in Yemen that affects predominantly poor rural women and children. Women with leishmaniasis often present late and experience not only physical deformities and the risk of death, but also the painful stigma of the disease and its consequences, a similar situation to that of leprosy decades ago. The International Society of Dermatology-sponsored community dermatology project Eradication of Leishmaniasis from Yemen Project has made a difference in the leishmaniasis situation in Yemen and addressed its magnitude. Read More

    Evaluation of occupational allergic contact dermatitis and its related factors in Iran.
    Med J Islam Repub Iran 2016 28;30:468. Epub 2016 Dec 28.
    Assistant Professor, Iran University of Medical Sciences, Tehran, Iran.
    Background: Occupational contact dermatitis, especially in hand, is one of the most common occupational disorders. The present study aimed at evaluating patients with occupational allergic contact dermatitis (ACD) caused by common allergens based on occupation type and disease history. Methods: This cross-sectional study aimed at evaluating the data of the patients with probable diagnosis of ACD in Center for Research and Training in Skin Diseases and Leprosy (CRTSDL) in Iran. Read More

    Modified simple decompression in the treatment of cubital tunnel syndrome: avoiding ulnar nerve subluxation.
    Arq Neuropsiquiatr 2017 Apr;75(4):238-243
    Schwarzwald Baar Klinikum, Division of Neurosurgery, Villigen-Schwennigen, Germany.
    Objective: In this study, we propose a modification to the simple decompression technique that contains the ulnar nerve in the cubital fossa, thus preventing subluxation during forearm flexion movements.

    Methods: Five consecutive patients with leprosy-associated cubital tunnel syndrome underwent surgery with the modified technique between July 2011 and October 2012.

    Results: The most common symptoms were neuropathic pain and sensory changes (both 60%). Read More

    Is Ross Syndrome an Autoimmune Entity? A Case Series of 11 Patients.
    Can J Neurol Sci 2017 May;44(3):318-321
    3Department of Neurology,Christian Medical College,Vellore,Tamil Nadu,India.
    Background: Ross syndrome is diagnosed by the presence of segmental anhidrosis, areflexia, and tonic pupils. Fewer than 60 cases have been described in literature so far. There have been reports of presence of antibodies in such patients, suggesting an autoimmune pathogenesis. Read More

    Fuzzy spectral clustering for automated delineation of chronic wound region using digital images.
    Comput Biol Med 2017 Apr 23. Epub 2017 Apr 23.
    School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India. Electronic address:
    Chronic wound is an abnormal disease condition of localized injury to the skin and its underlying tissues having physiological impaired healing response. Assessment and management of such wound is a significant burden on the healthcare system. Currently, precise wound bed estimation depends on the clinical judgment and remains a difficult task. Read More

    A medical enigma : what "gale chinoise (Chinese scabies)" meant 150 years ago.
    Med Sante Trop 2017 May 4. Epub 2017 May 4.
    Centre René Labusquière, Université de Bordeaux 3, Bordeaux, France.
    Context: The meaning of the term "gale chinoise" mentioned in some articles about French overseas territories in the 19th century, remains unclear. In response to a query of an American colleague dermatologist trying to find out what it meant 150 years ago, we attempted to elucidate the nature of this ancient disease, which today would be translated literally as Chinese scabies.

    Method: We submitted the query to a panel of civilian and military French tropical medicine specialists including dermatologists, through two networks : Association Amicale Santé Navale et d'Outre-Mer and Société de Pathologie Exotique. Read More

    Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens.
    PLoS Negl Trop Dis 2017 May 3;11(5):e0005560. Epub 2017 May 3.
    Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
    Household contacts of multibacillary leprosy patients (HCMB) constitute the group of individuals at the highest risk of developing leprosy. Early diagnosis and treatment of their index cases combined with Bacille Calmette-Guerin (BCG) immunization remain important strategies adopted in Brazil to prevent HCMB from evolving into active disease. In the present study, we assessed the impact of these measures on the immune response to Mycobacterium leprae in HCMB. Read More

    Prevalence and risk factors for hepatitis B and C viruses in patients with leprosy.
    Acta Trop 2017 Apr 28;172:160-163. Epub 2017 Apr 28.
    Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901, Recife, Pernambuco, Brazil; Department of Physiology and Pharmacology, Center for Biosciences, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901, Recife, Pernambuco, Brazil. Electronic address:
    It has been reported a higher seroprevalence of HBV and HCV in leprosy patients than in the general population, but the reasons for these findings are not yet clear. On the other hand, there is evidence that these viruses may influence the onset of leprosy reactional episodes, an important cause of neurological sequelae. This study aimed to determine seroprevalence and risk factors for HBV and HCV in leprosy patients and to investigate its association with leprosy reactions. Read More

    Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment?
    Infect Dis Poverty 2017 May 1;6(1):82. Epub 2017 May 1.
    Center of Health and Biological Science, Pará State University, Belém, Pará, Brazil.
    Background: The impact of leprosy reduces health-related quality of life of affected patients, interfering with different factors such as nutrition. This study investigated the lipid profile, nutritional status, and risk for cardiovascular disease (CVD) in patients who underwent leprosy treatment in Brazil.

    Methods: Eighty-four adult patients of both genders ranging in age from 20 to 60 years and diagnosed with paucibacillary (PB) or multibacillary (MB) leprosy were selected after undergoing multidrug treatment. Read More

    Lepromatous leprosy in a renal transplant recipient.
    Am J Transplant 2017 Apr 27. Epub 2017 Apr 27.
    Department of Nephrology, Haydarpaşa Numune Training and Research Hospital, İstanbul.
    Leprosy is a chronic granulomatous disease caused by acid fast bacillus Mycobacterium Leprae. It is rare in organ transplant patients; cases have been reported in three heart, one liver, and 12 renal transplantation patients in Worldwide (1,2). We report on a patient with lepromatous leprosy presenting six years after renal transplantation. Read More

    Leprosy in Children.
    Curr Infect Dis Rep 2017 Jun;19(6):23
    Dermato-Immunology Laboratory, Federal University of Pará, Av. João Paulo II, 113 - Bairro Dom Aristides, Marituba, Pará, CEP: 67200-000, Brazil.
    Purpose Of Review: This manuscript aims to review the cutting-edge developments regarding to the diagnosis, management, and prevention of leprosy in children.

    Recent Findings: Leprosy transmission still occurs continuously in some endemic areas in the world. Leprosy in children below 15 years old is a robust indicator of active source of infection in the community where they live. Read More

    Clinico-epidemiological profile of patients attending Suraksha Clinic of tertiary care hospital of North India.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):54-59
    Department of Skin and STD, Government Medical College, Amritsar, Punjab, India.
    Background: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area.

    Aims And Objectives: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases. Read More

    Study of pruritus vulvae in geriatric age group in tertiary hospital.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):15-21
    Department of Dermatology, Venereology, Leprosy, Government Medical College, Amritsar, Punjab, India.
    Background: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. Read More

    Knowledge and attitude about sexually transmitted infections other than HIV among college students.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):10-14
    Department of Dermatology, STD and Leprosy, Sapthagiri Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India.
    Background: Sexually transmitted infections (STIs) are the infections which are mainly transmitted through sexual intercourse. Young individuals in the age group of 16 to 24 years are considered to be at more risk for STIs compared to older adults. Young individuals are more likely to practice unprotected sex and have multiple sexual partners. Read More

    Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells?
    BMC Infect Dis 2017 Apr 24;17(1):305. Epub 2017 Apr 24.
    Laboratory of Medical Investigation Unit 56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
    Background: Due to its chronic subclinical course and large spectrum of manifestations, leprosy often represents a diagnostic challenge. Even with proper anti-mycobacteria treatment, leprosy follow up remains challenging: almost half of leprosy patients may develop reaction episodes. Leprosy is an infrequent complication of solid organ transplant recipients. Read More

    Feline leprosy due to Candidatus 'Mycobacterium tarwinense'.
    J Feline Med Surg 2017 May;19(5):498-512
    3 Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC 3000, Australia.
    Objectives: This paper, the first in a series of three on 'feline leprosy', provides a detailed description of disease referable to Candidatus 'Mycobacterium tarwinense', the most common cause of feline leprosy in Victoria, Australia.

    Methods: Cases were sourced retrospectively and prospectively for this observational study, describing clinical, geographical and molecular microbiological data for cats definitively diagnosed with Candidatus 'M tarwinense' infection.

    Results: A total of 145 cases of feline leprosy were scrutinised; 114 'new' cases were sourced from the Victorian Infectious Diseases Reference Laboratory records, veterinary pathology laboratories or veterinarians, and 31 cases were derived from six published studies. Read More

    International inter-rater agreement in scoring acne severity utilizing cloud-based image sharing of mobile phone photographs.
    Int J Dermatol 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, University of California - Davis, Sacramento, CA, USA.
    Background: Cloud-based image sharing technology allows facilitated sharing of images. Cloud-based image sharing technology has not been well-studied for acne assessments or treatment preferences, among international evaluators. We evaluated inter-rater variability of acne grading and treatment recommendations among an international group of dermatologists that assessed photographs. Read More

    Pathways and Genes Associated with Immune Dysfunction in Sheep Paratuberculosis.
    Sci Rep 2017 Apr 24;7:46695. Epub 2017 Apr 24.
    The Roslin Institute &R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG. U.K.
    Multibacillary and paucibacillary paratuberculosis are both caused by Mycobacterium avium subspecies paratuberculosis. Multibacillary lesions are composed largely of infected epithelioid macrophages and paucibacillary lesions contain T cells but few bacteria. Multibacillary disease is similar to human lepromatous leprosy, with variable/high levels of antibody and a dysfunctional immune response. Read More

    IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage.
    Braz J Infect Dis 2017 Apr 20. Epub 2017 Apr 20.
    Chhatrapati Shahu Ji Maharaj University, Institute of Life Sciences, Kanpur, India. Electronic address:
    Mycobacterium tuberculosis (MTB) adopts a special survival strategy to overcome the killing mechanism(s) of host immune system. Amongst the many known factors, small heat shock protein 16.3 (sHSP16. Read More

    Dapsone-associated fixed drug eruption.
    Expert Rev Clin Pharmacol 2017 Apr 28:1-9. Epub 2017 Apr 28.
    b Department of Dermatology , University of California, San Diego , La Jolla , CA , USA.
    Introduction: Dapsone is a sulfone drug used to treat infectious conditions and also numerous dermatologic diseases. Fixed drug eruption is a distinctive adverse cutaneous reaction associated with the initial administration and subsequent delivery of a specific agent. Areas covered: The authors preformed a literature search using the following keywords: dapsone, fixed drug eruption, and adverse cutaneous drug reaction. Read More

    An Innovative Cooling Jacket to Combat Heat Intolerance in Children with Anhidrosis.
    Pediatr Dermatol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Dermatology, Venereology and Leprosy, Sri B.M. Patil Medical College, Hospital and Research Center, BLDE University, Vijayapur, Karnataka, India.
    Hyperthermia and heat intolerance are distressing symptoms in patients with anhidrosis. Body cooling devices are an integral part of management of these patients. A cooling jacket made from easily available materials has been invented for a girl with congenital insensitivity to pain and anhidrosis with severe heat intolerance. Read More

    Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions Th17 Immune Response in Leprosy.
    Scand J Immunol 2017 Apr 20. Epub 2017 Apr 20.
    Laboratory of Molecular Biology, Universidade Federal de Sergipe (UFS), Brazil.
    It is well established that helper T cell responses influence resistance or susceptibility to Mycobacterium leprae infection, but the role of more recently described helper T cell subsets in determining severity is less clear. To investigate the involvement of Th17 cells in the pathogenesis of leprosy, we determined the immune profile with variant presentations of leprosy. Firstly, IL-17A, IFN-γ and IL-10 were evaluated in conjunction with CD4(+) T cell staining by confocal microscopy of lesion biopsies from tuberculoid (TT) and lepromatous (LL) patients. Read More

    Trend of leprosy in individuals under the age of 15 in Mato Grosso (Brazil), 2001-2013.
    Rev Saude Publica 2017 Apr 10;51:28. Epub 2017 Apr 10.
    Programa de Pós-Graduação. Faculdade de Enfermagem. Universidade de Cuiabá e Universidade Federal de Mato Grosso. Cuiabá, MT, Brasil.
    Objective: To identify the historical trend of leprosy epidemiological indicators in individuals under the age of 15 in the state of Mato Grosso.

    Methods: Descriptive study with trend analysis of leprosy indicators in individuals under the age of fifteen registered in the Mato Grosso's System for Notifiable Diseases between 2001 and 2013. We used the Prais-Winsten procedure for analyzing generalized linear regression at a significance level of 5%. Read More

    Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis.
    PLoS One 2017 18;12(4):e0175743. Epub 2017 Apr 18.
    Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular, Centro Biomédico, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, Rio de Janeiro, Brazil.
    Leprosy is a chronic granulomatous infection of skin and peripheral nerves caused by Mycobacterium leprae and is considered the main infectious cause of disability worldwide. Despite the several studies regarding leprosy, little is known about its effects on microvascular structure and function in vivo. Thus, we have aimed to compare skin capillary structure and functional density, cutaneous vasomotion (spontaneous oscillations of arteriolar diameter), which ensures optimal blood flow distribution to skin capillaries) and cutaneous microvascular blood flow and reactivity between ten men with lepromatous leprosy (without any other comorbidity) and ten age- and gender-matched healthy controls. Read More

    Quinolone resistance-associated amino acid substitutions affect enzymatic activity of Mycobacterium leprae DNA gyrase.
    Biosci Biotechnol Biochem 2017 Apr 18:1-5. Epub 2017 Apr 18.
    a Division of Bioresources , Hokkaido University Research Center for Zoonosis Control , Sapporo , Japan.
    Quinolones are important antimicrobials for treatment of leprosy, a chronic infectious disease caused by Mycobacterium leprae. Although it is well known that mutations in DNA gyrase are responsible for quinolone resistance, the effect of those mutations on the enzymatic activity is yet to be studied in depth. Hence, we conducted in vitro assays to observe supercoiling reactions of wild type and mutated M. Read More

    Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy.
    Neurosci Lett 2017 May 12;649:85-92. Epub 2017 Apr 12.
    Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China. Electronic address:
    Post-operative cognitive dysfunction (POCD) is a commonly seen postoperative complication in elderly patients and its underlying mechanisms are still unclear. Autophagy, a degradation mechanism of cellular components, is required for cell survival and many physiological processes. Although propofol is one of the most commonly used intravenous anesthetics, investigations into its mechanisms and effects on cognition in aged rodents are relatively scarce. Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Clinicoepidemiological and Mycological Study of Tinea Capitis in the Pediatric Population of Kashmir Valley: A Study from a Tertiary Care Centre.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):100-103
    Department of Microbiology, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.
    Background: Tinea capitis is a superficial fungal infection that predominantly affects the pediatric population. The etiological factors vary from region to region, and the exact incidence remains obscure. The clinicoepidemiological and mycological aspects of this dermatophytosis were studied in a tertiary care centre in Kashmir valley. Read More

    1 OF 517