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    Characterization of Ofloxacin Interaction with Mutated (A91V) Quinolone Resistance Determining Region of DNA Gyrase in Mycobacterium Leprae through Computational Simulation.
    Cell Biochem Biophys 2017 Aug 18. Epub 2017 Aug 18.
    Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
    Mycobacterium leprae, the causal agent of leprosy is non-cultivable in vitro. Thus, the assessment of antibiotic activity against Mycobacterium leprae depends primarily upon the time-consuming mouse footpad system. The GyrA protein of Mycobacterium leprae is the target of the antimycobacterial drug, Ofloxacin. Read More

    [Cutaneous tuberculosis in Bamako, Mali].
    Pan Afr Med J 2017 8;27:102. Epub 2017 Jun 8.
    Service de Dermatologie, Centre National d'Appui à la Lutte contre la Maladie, Bamako, Mali.
    Introduction: Tuberculosis is the most common mycobacteriosis in sub-Saharan Africa. Cutaneous tuberculosis is rare and underdiagnosed due to its clinical polymorphism and to the smallness of technical equipment. This study aims to describe the epidemiological, clinical, histopathological aspects of cutaneous tuberculosis in Bamako (Mali). Read More

    Complete Genome Sequence of Mycobacterium stephanolepidis.
    Genome Announc 2017 Aug 17;5(33). Epub 2017 Aug 17.
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Mycobacterium stephanolepidis is a rapid-growing nonpigmented species isolated from marine teleost fish (Stephanolepis cirrhifer) and is closely related to Mycobacterium chelonae Here, we report the complete sequence of its genome, comprising a 4.9-Mb chromosome. The sequence represents essential data for future phylogenetic and comparative genome studies of this fish pathogen. Read More

    An outlier in public health history in India: A.T.W. Simeons's scheme for rural medical relief, Kolhapur, 1943-47.
    Natl Med J India 2017 Mar-Apr;30(2):103-107
    Acworth Leprosy Hospital, Society for Research, Rehabilitation and Education in Leprosy, Wadala, Mumbai 400031, Maharashtra, India.
    It is customary to date provision of health services in rural India to the Report of the Bhore Committee (1946) and its descendants. It is presumed that in pre-Bhore India (the last half-century of the British era) the rural public health scenario was devoid of discerning commentators and practical effort. The presumption is misleading. Read More

    Short-term leprosy forecasting from an expert opinion survey.
    PLoS One 2017 16;12(8):e0182245. Epub 2017 Aug 16.
    Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America.
    We conducted an expert survey of leprosy (Hansen's Disease) and neglected tropical disease experts in February 2016. Experts were asked to forecast the next year of reported cases for the world, for the top three countries, and for selected states and territories of India. A total of 103 respondents answered at least one forecasting question. Read More

    Lychee-associated acute hypoglycaemic encephalopathy outbreaks in Muzaffarpur, India - Author's reply.
    Lancet Glob Health 2017 Sep;5(9):e861-e862
    Global Disease Detection Program-India, US Centers for Disease Control and Prevention, New Delhi, India; Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, GA, USA.

    A skeletal case of hypertrophic osteoarthropathy from the Canary Islands dating from 1000 BP.
    Int J Paleopathol 2015 Dec 3;11:1-6. Epub 2015 Aug 3.
    Departamento de Geografía e Historia, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
    A left tibia, the distal right tibia, and the proximal four fifths of the right ulna and radius, probably belonging to an adult prehispanic man (antiquity of ≈1000 years BP) were found among commingled bone remains in a collective burial cave of the island of El Hierro, in the Canary Archipelago. All four bones show an intense periosteal bone formation, encrusting the preserved cortical bone of the diaphyses. Differential diagnosis include melorheostosis, syphilis, and leprosy, although the most likely diagnosis is hypertrophic osteoarthropathy, which is usually associated with lung neoplasm or non-malignant diseases leading to chronic hypoxemia. Read More

    Sustained expression of DevR/DosR during long-term hypoxic culture of Mycobacterium tuberculosis.
    Tuberculosis (Edinb) 2017 Sep 27;106:33-37. Epub 2017 Jun 27.
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India; Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Faridabad, Haryana, India. Electronic address:
    DevR/DosR is a key mediator of 'dormancy' adaptation in Mycobacterium tuberculosis in response to gaseous stresses such as hypoxia that inhibit aerobic mode of respiration. In the present study, a temporal analysis over a 1 year period has revealed robust expression of representative DevR regulon genes devR, hspX and tgs1, during long-term 'dormancy' adaptation to hypoxia. Notably, a predominant proportion of long-term hypoxia-adapted bacteria were characterized by their inability to grow on solid media, accumulation of triacylglycerols and recovery of growth in liquid media. Read More

    A synopsis of the history of Hansen's disease.
    Wien Med Wochenschr 2017 Aug 11. Epub 2017 Aug 11.
    University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
    Leprosy is a contagious infectious disease caused by the bacillus Mycobacterium leprae. This microorganism was discovered by Dr. Gerhard Hansen, and the illness was then baptized as Hansen's disease. Read More

    Enhanced Worldwide Dermatology-Pathology Interaction via Facebook, Twitter, and Other Social Media Platforms.
    Am J Dermatopathol 2017 Aug 3. Epub 2017 Aug 3.
    *Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Sawangi (Meghe), India; and †Departments of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR.
    The practice of dermatopathology requires close interaction between dermatologists and dermatopathologists. Yet, in many areas of the developing world, dermatologists lack easy access to pathologists with expertise in skin disease. Twitter, Facebook, and other social media provide free powerful tools that enhance interaction between dermatology and pathology regardless of geographic barriers. Read More

    Mucocutaneous Manifestations in Patients with Rheumatoid Arthritis: A Cross-sectional Study from Eastern India.
    Indian J Dermatol 2017 Jul-Aug;62(4):411-417
    Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, West Bengal, India.
    Background: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease.

    Aims: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India.

    Methodology: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India. Read More

    Vitamin D Level in Alopecia Areata.
    Indian J Dermatol 2017 Jul-Aug;62(4):407-410
    Department of Dermatology, STD and Leprosy, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.
    Background: Alopecia areata (AA) is an immune-mediated disease in which autoantigens play an important part in activating T-lymphocytes. Vitamin D has been associated with various autoimmune diseases, and Vitamin D receptors are strongly expressed in hair follicles and their expression in keratinocytes is necessary for the maintenance of the normal hair cycle.

    Aim: The aim of this study was to find the association between Vitamin D level and AA. Read More

    Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.
    PLoS Genet 2017 Aug 9;13(8):e1006952. Epub 2017 Aug 9.
    Program in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
    Leprosy is a human infectious disease caused by Mycobacterium leprae. A strong host genetic contribution to leprosy susceptibility is well established. However, the modulation of the transcriptional response to infection and the mechanism(s) of disease control are poorly understood. Read More

    Factors associated with the functional capacity of older adults with leprosy.
    Rev Bras Enferm 2017 Jul-Aug;70(4):711-718
    Universidade Federal do Ceará, Faculty of Pharmacy Dentistry and Nursing, Postgraduate Program in Nursing. Fortaleza, Ceará, Brazil.
    Objective:: to investigate the association between socio-demographic and clinical factors and the functional capacity of older adults with leprosy.

    Method:: cross-sectional analytical study conducted in Fortaleza, Ceará, Brazil, with 77 older adult patients with leprosy in a referral service, through interview, medical records and application of the Katz Index and the Lawton and Brody Scale.

    Results:: the mean age was 68. Read More

    The role of DNA polymerase chain reaction, culture and histopathology in the diagnosis of cutaneous tuberculosis.
    Int J Dermatol 2017 Aug 9. Epub 2017 Aug 9.
    Department of Skin, STD and Leprosy, S.M.S. Medical College & Hospital, Jaipur, Rajasthan, India.
    Background: Cutaneous tuberculosis (TB) is re-emerging as a significant problem in India due to increased incidence of human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), other immunosuppressive states/factors like drugs, and emergence of multidrug resistance (MDR-TB). Proper diagnosis is warranted as there is varied clinical presentation and similarity with many other diseases.

    Objective: To assess the sensitivities of DNA polymerase chain reaction (PCR), culture, and histopathology for the diagnosis of cutaneous TB in clinically suspected skin lesions. Read More

    An observational study on the effects of aviation turbine fuel and lubricants on the skin of Indian Air Force ground crew in flying stations.
    Med J Armed Forces India 2017 Jul 11;73(3):294-298. Epub 2016 Aug 11.
    Assistant Surgeon, O/o Deputy Director Medical Services (Leprosy), Collectorate, Salem District, Tamil Nadu 636001, India.
    Background: Ground crew of the Air Force routinely handle aviation turbine fuel (ATF) and lubricants and a need was felt to study the adverse effects of these substances on their skin so that remedial measures could be taken to prevent these adverse effects.

    Methods: A multi-centric, cross-sectional, observational study was performed at three Air Force flying stations. 109 ground crew members of the Indian Air Force (IAF) who were in direct contact with ATF and lubricants were screened for dermatological manifestations on exposed areas. Read More

    Prioritization of natural compounds against mycobacterium tuberculosis 3-dehydroquinate dehydratase: A combined in-silico and in-vitro study.
    Biochem Biophys Res Commun 2017 Aug 5. Epub 2017 Aug 5.
    Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar 382030, Gujarat, India. Electronic address:
    Enormous efforts have been endeavored to develop inhibitors against the potential therapeutic target, mycobacterium tuberculosis 3-dehydroquinate dehydratase (MtbDHQase) to combat resistance. Over a dozen of small molecules have been crystallized to characterize the structural basis of the inhibition. However, the studies accomplished so far, have not incorporated all the essential interactions of these complexes simultaneously, to identify the novel inhibitors. Read More

    What happened to patients with RMP-resistant/MDR-TB in Zambia reported as lost to follow-up from 2011 to 2014?
    Int J Tuberc Lung Dis 2017 Aug;21(8):887-893
    National TB and Leprosy Control Programme, Lusaka, Zambia; Department of Public Health and Research, Ministry of Health, Lusaka, Zambia.
    Setting: University Teaching Hospital, Lusaka, and Ndola Central Hospital, Ndola, Zambia, which implemented active tracing of multidrug-resistant tuberculosis (MDR-TB) patients reported as lost to follow-up (LTFU).

    Objective: To determine 1) the number of patients treated for MDR-TB between 2011 and 2014; 2) the number, proportion, month when LTFU and characteristics of patients registered as LTFU; and 3) final outcomes observed following active patient tracing.

    Design: Retrospective cohort study. Read More

    Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda.
    Int J Tuberc Lung Dis 2017 Aug;21(8):862-868
    Mbarara University of Science and Technology, Mbarara, Uganda.
    Setting: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children.

    Objective: To assess the feasibility and yield of hospital-based screening and IPT in Uganda, and to evaluate the utility of symptom-based screening.

    Design: Household child (age <5 years) contacts of adults with pulmonary TB were assessed for TB or latent tuberculous infection (LTBI). Read More

    Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
    PLoS Negl Trop Dis 2017 Aug 4;11(8):e0005834. Epub 2017 Aug 4.
    Department of Pathology, Kagoshima University, Kagoshima, Japan.
    Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. Read More

    Preservation of sputum samples with cetylpyridinium chloride (CPC) for tuberculosis cultures and Xpert MTB/RIF in a low-income country.
    BMC Infect Dis 2017 Aug 4;17(1):542. Epub 2017 Aug 4.
    Ifakara Health Institute, Bagamoyo, Tanzania.
    Background: Culture contamination with environmental bacteria is a major challenge in tuberculosis (TB) laboratories in hot and humid climate zones. We studied the effect of cetylpyridinium chloride (CPC) preservation on culture results and performance of Xpert MTB/RIF.

    Methods: Consecutive sputum samples from microscopy smear-positive TB patients were collected. Read More

    An evaluation of innovative community-based approaches and systematic tuberculosis screening to improve tuberculosis case detection in Ebonyi State, Nigeria.
    Int J Mycobacteriol 2017 Jul-Sep;6(3):246-252
    Department of Internal Medicine, Federal University Teaching Hospital, Abakaliki, Nigeria.
    Background: National tuberculosis (TB) programmes globally rely heavily on passive case finding for detecting TB in the community as advocated by the World Health Organization (WHO). TB case detection is low in Nigeria despite improvement in TB services and coverage.

    Methods: A retrospective evaluation of an active case-finding intervention utilizing community-based approaches and targeted systematic TB screening in Ebonyi State, Nigeria was done. Read More

    Challenges beyond elimination in leprosy.
    Int J Mycobacteriol 2017 Jul-Sep;6(3):222-228
    Director Incharge, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar Pradesh, India.
    Every year >200,000 new leprosy cases are registered globally. This number has been fairly stable over the past 8 years. The World Health Organization has set a target to interrupt the transmission of leprosy globally by 2020. Read More

    Case of Mycobacterium haemophilum misdiagnosed as Mycobacterium intracellulare due to one base insertion in the bacterial genome.
    J Dermatol 2017 Aug 3. Epub 2017 Aug 3.
    Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
    Mycobacterium haemophilum is a slow-growing, non-tuberculous mycobacteria that causes cutaneous infection. We describe a case of cutaneous infection in a 68-year-old Japanese man with polymyositis. This was caused by M. Read More

    Distinct clinico-immunological profile of patients infected with human papilloma virus genotypes 6 and 11.
    Virusdisease 2017 Jun 20;28(2):200-204. Epub 2017 May 20.
    Room NO. 92B, Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
    Anogenital warts are primarily caused by Human Papillomavirus (HPV) type 6 and 11, which belong to the taxonomic family Papillomaviridae, genus alpha-papillomavirus and species 10. The presentation of the warts is varied and most of the patients have high recurrence rate of wart lesions. Studies had shown that an effective cellular immune response is required for the control of HPV infection. Read More

    Bullous Erythema Nodosum Leprosum as the First Manifestation of Multibacillary Leprosy: A Rare Phenomenon.
    Am J Dermatopathol 2017 Jul 24. Epub 2017 Jul 24.
    Departments of *Histopathology, and †Dermatology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.
    Erythema nodosum leprosum (ENL) may uncommonly present before treatment in patients with multibacillary leprosy. Atypical manifestations are known in ENL and may be clinically misleading. Such wide variations in the clinical presentation of leprosy in reaction make histopathology an important tool for supporting clinical diagnosis. Read More

    Multiple Verrucous Hemangiomas: A Case Report with New Therapeutic Insight.
    Indian Dermatol Online J 2017 Jul-Aug;8(4):254-256
    Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research (PGIMER) and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
    Verrucous hemangioma is an uncommon congenital vascular malformation, which may clinically masquerade angiokeratoma, lymphangioma circumscriptum, or malignant melanoma. Differentiation is essential owing to varied therapeutic and prognostic implications. We present a rare case of multiple verrucous hemangiomas in a teenage girl who presented with multiple warty lesions over the dorsal aspect of the left foot since birth. Read More

    Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions.
    Sci Rep 2017 Jul 28;7(1):6810. Epub 2017 Jul 28.
    Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
    Bacteria can proliferate perpetually without ageing, but they also face conditions where they must persist. Mycobacteria can survive for a long period. This state appears during mycobacterial diseases such as tuberculosis and leprosy, which are chronic and develop after long-term persistent infections. Read More

    Extensive sonographic ulnar nerve enlargement above the medial epicondyle is a characteristic sign in Hansen's neuropathy.
    PLoS Negl Trop Dis 2017 Jul 28;11(7):e0005766. Epub 2017 Jul 28.
    Department of Neurology and Clinical Neurophysiology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
    Objective: Earlier studies have shown sonographic enlargement of the ulnar nerve in patients with Hansen's neuropathy. The present study was performed to determine whether sonography or electrophysiological studies can detect the specific site of ulnar nerve pathology in leprosy.

    Methods: Eighteen patients (thirty arms) with Hansen's disease and an ulnar neuropathy of whom 66% had borderline tuberculoid (BT), 27% lepromatous leprosy (LL) and 7% mid-borderline (BB) leprosy were included in the study. Read More

    Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis.
    PLoS One 2017 27;12(7):e0180677. Epub 2017 Jul 27.
    Federal University of Pará, Tropical Medicine Nucleus, Belem, Pará, Brazil.
    Objective: To evaluate the heart rate variability (HRV) in patients with multibacillary leprosy using dynamic linear and nonlinear analysis.

    Material And Methods: Twenty-one leprosy patients (mean age: 39.14 ±10. Read More

    Assessment of immunomodulatory activity of aqueous extract of Calamus rotang.
    Avicenna J Phytomed 2017 May-Jun;7(3):199-205
    Vidya Pratishthan's School of Biotechnology (VSBT, Research centre affiliated to Savitribai Phule Pune University) Baramati, Maharashtra, India.
    Objective: There are a number of medicinal plant products which has been used to treat various immunological diseases. Out of these medicinal plants, Calamus rotang has shown several medicinal properties including anti-viral, anti-diabetic, anti-inflammatory effects. Normally, the roots of C. Read More

    Social determinants of leprosy in a hyperendemic State in North Brazil.
    Rev Saude Publica 2017 Jul 20;51:70. Epub 2017 Jul 20.
    Departamento de Saúde Comunitária. Faculdade de Medicina. Universidade Federal do Ceará. Fortaleza, CE, Brasil.
    Objective: To identify the socioeconomic, demographic, operational, and health service-related factors associated with the occurrence of leprosy in a hyperendemic State in North Brazil.

    Methods: This is an ecological study based on secondary data from the Sistema de Informações de Agravos de Notificação in municipalities of the State of Tocantins from 2001 to 2012. Units of analysis were the 139 municipalities of the State. Read More

    Hearing thresholds in patients with drug-resistant tuberculosis: baseline audiogram configurations and associations.
    J Bras Pneumol 2017 May-Jun;43(3):195-201
    . Ogun State Tuberculosis, Leprosy and Buruli Ulcer Control Program, Ministry of Health, Ogun State, Nigeria.
    Objective:: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations.

    Methods:: This was a prospective study involving patients diagnosed with DR-TB at a tuberculosis treatment center in the state of Ogun, in Nigeria. The patients included in the study were submitted to pure tone audiometry at baseline (within two weeks after treatment initiation). Read More

    The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.
    Chem Res Toxicol 2017 Aug 2;30(8):1622-1628. Epub 2017 Aug 2.
    Departments of Chemistry and Life Sciences, SONS, Shiv Nadar University , Greater Noida, Uttar Pradesh 201314, India.
    Thalidomide [α-(N-phthalimido)glutarimide] (1) is a sedative and antiemetic drug originally introduced into the clinic in the 1950s for the treatment of morning sickness. Although marketed as entirely safe, more than 10 000 babies were born with severe birth defects. Thalidomide was banned and subsequently approved for the treatment of multiple myeloma and complications associated with leprosy. Read More

    pH-sensitive nanoparticles for improved oral delivery of dapsone: risk assessment, design, optimization and characterization.
    Nanomedicine (Lond) 2017 Aug 26;12(16):1975-1990. Epub 2017 Jul 26.
    UCIBIO, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
    Aim: To optimize the production of pH-sensitive dapsone (DAP) nanoparticles based on Eugradit L100 (NPs-EL100-DAP) for oral delivery.

    Materials & Methods: NPs-EL100-DAP were optimized using a Plackett-Burman design and a Box-Behnken design. The physicochemical properties of the obtained nanoparticles were monitored by microscopy, dynamic light scattering, Fourier transform infrared spectroscopy, differential scanning calorimetry, in vitro release assays, and examined for cytotoxicity and permeation across intestinal barrier. Read More

    Influence of Ebola on tuberculosis case finding and treatment outcomes in Liberia.
    Public Health Action 2017 Jun;7(Suppl 1):S62-S69
    National Leprosy & Tuberculosis Control Programme, Ministry of Health, Monrovia, Liberia.
    Setting: National Leprosy and Tuberculosis (TB) Control Programme, Liberia. Objectives: To assess TB case finding, including human immunodeficiency virus (HIV) associated interventions and treatment outcomes, before (January 2013-March 2014), during (April 2014-June 2015) and after (July-December 2015) the Ebola virus disease outbreak. Design: A cross-sectional study and retrospective cohort analysis of outcomes. Read More

    Identification of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors: A combined in-silico and in-vitro analysis.
    J Mol Graph Model 2017 Jul 14;76:172-180. Epub 2017 Jul 14.
    Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, 382030, Gujarat, India. Electronic address:
    Mycobacterium tuberculosis (Mtb), had developed evolutionary changes in its genome to adapt for survival and thereby generated multi-drug resistant strains. However, novel drug targets that remained unchanged for their biochemical role has impressed the research community to target such proteins. The comprehensive analysis of multiple protein targets has influenced us to make a consensus structural rule exploited by pharmacophore and other allied techniques from a large repository of protein structures. Read More

    Infectious diseases causing autonomic dysfunction.
    Clin Auton Res 2017 Jul 20. Epub 2017 Jul 20.
    Neurology Department, Raigmore Hospital, Inverness, UK.
    Objectives: To review infectious diseases that may cause autonomic dysfunction.

    Methods: Review of published papers indexed in medline/embase.

    Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

    Adverse reactions in leprosy patients who underwent dapsone multidrug therapy: a retrospective study.
    Clin Pharmacol 2017 29;9:73-78. Epub 2017 Jun 29.
    Dermatology Department, Green Pastures Hospital and Rehabilitation Centre, Pokhara, Nepal.
    Objective: To investigate the occurrence and clinical characteristics of dapsone-related adverse drug reactions (ADRs) among leprosy patients who underwent multidrug therapy (MDT) from 2010 to 2013 in the western region of Nepal.

    Methods: A retrospective review was carried out in the rehabilitation center. Data were collected from the record files of the hospital. Read More

    Therapeutic Dilemma of Refractory Erythema Nodosum Leprosum.
    Am J Trop Med Hyg 2017 Jun;96(6):1362-1364
    Department of Leprosy, Shanghai Dermatology Hospital, Shanghai, People's Republic of China.
    AbstractErythema nodosum leprosum (ENL), also known as type II leprosy reaction, is a severe immune-mediated complication of multibacillary leprosy. For ENL, corticosteroids and thalidomide are the mainstays of treatment. Other immunosuppressants, such as clofazimine, cyclosporine, and azathioprine have also been used. Read More

    Leprosy in a Lombard-Avar cemetery in central Italy (Campochiaro, Molise, 6th-8th century AD): ancient DNA evidence and demography.
    Ann Hum Biol 2017 Jul 17:1-12. Epub 2017 Jul 17.
    e Centre for Clinical Microbiology , Division of Infection and Immunity , UCL , London , UK.
    Background: The study of past infectious diseases increases knowledge of the presence, impact and spread of pathogens within ancient populations.

    Aim: Polymerase chain reaction (PCR) was used to examine bones for the presence of Mycobacterium leprae ancient DNA (aDNA) as, even when leprosy is present, bony changes are not always pathognomonic of the disease. This study also examined the demographic profile of this population and compared it with two other populations to investigate any changes in mortality trends between different infectious diseases and between the pre-antibiotic and antibiotic eras. Read More

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