Search our Database of Scientific Publications and Authors

I’m looking for a

    25663 results match your criteria Leprosy

    1 OF 514

    Fine Needle Aspiration Cytology of Papulonodular Lesions of Skin: A Study of 50 Cases.
    J Clin Diagn Res 2016 Dec 1;10(12):EC09-EC13. Epub 2016 Dec 1.
    Professor and Head of Department, Department of Pathology, JSS Medical College, JSS University , Mysuru, Karnataka, India .
    Introduction: Skin is one of the frequent site of disease in human body. Fine Needle Aspiration Cytology (FNAC) is a safe diagnostic method in these cases. FNAC has some limitation, particularly related to representativity of samples, exact typing of skin adnexal tumours and classifying the nature of metastatic cutaneous nodules. Read More

    Rifampicin-induced disseminated intravascular coagulation in pulmonary tuberculosis treatment: A case report and literature review.
    Medicine (Baltimore) 2017 Feb;96(7):e6135
    aDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University bDepartment of Geriatrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
    Rationale: Disseminated intravascular coagulation (DIC) induced by daily rifampicin therapy is rare, especially the patient is absent of malignancy, severe infection, and prior exposure to rifampicin.

    Patient Concerns: We report a case of DIC induced by daily rifampicin treatment for pulmonary tuberculosis. A 22-year-old, previously healthy man received an anti-tuberculosis therapy consisting of isoniazid, rifampicin, ethambutol, and pyrazinamide on the daily dose recommended by the World Health Organization tuberculosis guidelines after a diagnosis of pulmonary tuberculosis. Read More

    LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
    Biochem Soc Trans 2017 Feb;45(1):131-139
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.
    Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in familial and idiopathic cases of Parkinson's disease (PD), but are also associated with immune-related disorders, notably Crohn's disease and leprosy. Although the physiological function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in neurodegenerative diseases, including PD. Innate immunity involves macrophages and microglia, in which endogenous LRRK2 expression is precisely regulated and expression is strongly up-regulated upon cell activation. Read More

    Personality disorders and its association with anxiety and depression among patients of severe acne: A cross-sectional study from Eastern India.
    Indian J Psychiatry 2016 Oct-Dec;58(4):378-382
    Department of Psychiatry, Calcutta National Medical College, Kolkata, West Bengal, India.
    Background: In many patients, emotional stress may exacerbate acne. Psychological problems such as social phobias, low self-esteem, or depression may also occur as a result of acne. The presence of acne may have some negative effect on the quality of life, self-esteem, and mood of the affected patients. Read More

    Update on etiopathogenesis and treatment of Acne.
    Indian J Dermatol Venereol Leprol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Dermatology, STD and Leprosy, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.
    Acne, the most common skin disease, is a disorder of pilosebaceous units that affects adolescents mainly and adults occasionally. The pathogenesis is multifactorial. Besides genetic predisposition, other major factors include the action of androgens, pro-inflammatory lipids acting as ligands of peroxisome proliferator-activated receptors in the sebocytes, toll-like receptor-2 acting on keratinocytes, recognition of pathogen-associated molecular patterns, cytokines, chemokines, inflammasomes, neuroendocrine regulatory mechanisms, diet and other pro-inflammatory targets implicated in the activation of immune detection and response. Read More

    Sural artery perforator flap with posterior tibial neurovascular decompression for recurrent foot ulcer in leprosy patients.
    GMS Interdiscip Plast Reconstr Surg DGPW 2017 31;6:Doc01. Epub 2017 Jan 31.
    Plastic Surgery Department, Mansoura University, Mansoura, Egypt.
    Introduction: The sensory loss and alteration of the shape of the foot make the foot liable to trauma and pressure, and subsequently cause more callus formation, blisters, and ulcers. Foot ulcers usually are liable to secondary infection as cellulitis or osteomyelitis, and may result in amputations. Foot ulcers are a major problem and a major cause of handicaps in leprosy patients. Read More

    Multibacillary leprosy by population groups in Brazil: Lessons from an observational study.
    PLoS Negl Trop Dis 2017 Feb 13;11(2):e0005364. Epub 2017 Feb 13.
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.
    Background: Leprosy remains an important public health problem in Brazil where 28,761 new cases were diagnosed in 2015, the second highest number of new cases detected globally. The disease is caused by Mycobacterium leprae, a pathogen spread by patients with multibacillary (MB) leprosy. This study was designed to identify population groups most at risk for MB disease in Brazil, contributing to new ideas for early diagnosis and leprosy control. Read More

    Sexually transmitted infection prevalence and related risk factors among heterosexual male methamphetamine users in China.
    Int J STD AIDS 2017 Jan 1:956462417693165. Epub 2017 Jan 1.
    4 Department of Dermatology, The Third hospital of Chengyang, Qingdao, China.
    Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11. Read More

    A Review on Dapsone Hypersensitivity Syndrome Among Chinese Patients with an Emphasis on Preventing Adverse Drug Reactions with Genetic Testing.
    Am J Trop Med Hyg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Dermatology and Venereology, Shandong Provincial Institute of Dermatology and Venereology, Shandong University, Jinan, China
    Dapsone is a bactericidal and bacteriostatic against Mycobacterium leprae, a causative agent of leprosy. Dapsone is also applied in a range of medical fields because of its anti-inflammatory and immunomodulatory effects. Dapsone hypersensitivity syndrome (DHS) is a rare yet serious adverse drug reaction (ADR) caused by dapsone involving multiple organs. Read More

    Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.
    Nat Genet 2017 Feb 6. Epub 2017 Feb 6.
    Inflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P < 5 × 10(-8)) by direct genotyping and ADO-EGR2 by imputation. Read More

    Outcome of Flap Surgeries in Dermatosurgical Unit at a Tertiary Care Centre in India with a Review of Literature.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):226-231
    Department of Dermatology, Bangalore Medical College and Research Institute, Victoria Hospital, Bengaluru, Karnataka, India.
    Introduction: Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit.

    Materials And Methods: A total of 35 flap surgeries performed from January 2012 to December 2014 formed part of the study. Read More

    The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy.
    Infect Dis Poverty 2017 Feb 6;6(1). Epub 2017 Feb 6.
    Department of Medicine, Molecular Biology Laboratory, University Hospital, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil.
    Leprosy is a chronic infectious disease caused by Mycobacterium leprae. According to official reports from 121 countries across five WHO regions, there were 213 899 newly diagnosed cases in 2014. Although leprosy affects the skin and peripheral nerves, it can present across a spectrum of clinical and histopathological forms that are strongly influenced by the immune response of the infected individuals. Read More

    A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis.
    PLoS Negl Trop Dis 2017 Feb 3;11(2):e0005373. Epub 2017 Feb 3.
    California Institute for Biomedical Research, La Jolla, California, United States of America.
    Cryptosporidiosis has emerged as a leading cause of non-viral diarrhea in children under five years of age in the developing world, yet the current standard of care to treat Cryptosporidium infections, nitazoxanide, demonstrates limited and immune-dependent efficacy. Given the lack of treatments with universal efficacy, drug discovery efforts against cryptosporidiosis are necessary to find therapeutics more efficacious than the standard of care. To date, cryptosporidiosis drug discovery efforts have been limited to a few targeted mechanisms in the parasite and whole cell phenotypic screens against small, focused collections of compounds. Read More

    Leprosy trends at a tertiary care hospital in Mumbai, India, from 2008 to 2015.
    Glob Health Action 2016 Jan;9(1):32962
    a German Leprosy and TB Relief Association Chennai , India.
    Background Leprosy remains an important cause of preventable disabilities. After the advent of multidrug therapy, new leprosy cases have come down dramatically. Despite this achievement, India, which contributes 60% of the global leprosy burden, faces some challenges to eliminate the disease, including active transmission in the community and delayed diagnosis of leprosy patients. Read More

    Nasal PCR assay for the detection of Mycobacterium leprae pra gene to study subclinical infection in a community.
    Microb Pathog 2017 Jan 27;104:336-339. Epub 2017 Jan 27.
    Central Leprosy Teaching & Research Institute, Chengalpattu, Tamil Nadu, India.
    Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Identification of Mycobacterium leprae is difficult in part due to the inability of the leprosy bacillus to grow in vitro. A number of diagnostic methods for leprosy diagnosis have been proposed. Read More

    A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica.
    Reprod Toxicol 2017 Jan 24. Epub 2017 Jan 24.
    School of Integrative Biology, 505 South Goodwin Avenue, University of Illinois, Urbana, IL 61801, USA; Institute for Genomic Biology, 1206 W Gregory Drive, University of Illinois, Urbana, IL 61801, USA. Electronic address:
    From 1957 to 1962, thalidomide caused birth defects in >10,000 children. While the drug was pulled from the market, thalidomide is currently prescribed to treat conditions including leprosy. As a result, a new generation of babies with thalidomide defects is being born in the developing world. Read More

    Modulation of the Immune Response to DNA Vaccine Encoding Gene of 8-kDa Subunit of Echinococcus granulosus Antigen B Using Murine Interleukin-12 Plasmid in BALB/c Mice.
    Iran J Parasitol 2016 Oct-Dec;11(4):480-489
    Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran.
    Background: The current study was designed to evaluate immune responses induced by DNA vaccines encoding 8-kDa subunit of antigen B (HydI) of Echinococcus granulosus and murine interleukin 12 (IL-12) as genetic adjuvants in BALB/c mice.

    Methods: Expression plasmid pcDNA3.1 containing HydI (pcHyd1) as vaccine along with the murine interleukin 12 (pcMIL12) as adjuvant were used. Read More

    Antigen-specific secretion of IFNγ and CXCL10 in whole blood assay detects Mycobacterium leprae infection but does not discriminate asymptomatic infection from symptomatic leprosy.
    Diagn Microbiol Infect Dis 2017 Jan 5. Epub 2017 Jan 5.
    Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO 74605-020, Brazil. Electronic address:
    To advance toward a whole blood assay (WBA)-based test capable of facilitating the diagnosis of paucibacillary (PB) leprosy, we evaluated a prototype in-tube WBA using combinations of Mycobacterium leprae antigens. Blood was collected from newly diagnosed untreated PB (n=38), multibacillary (MB) (n=30), healthy household contacts (HHC) of MB (n=27), and endemic controls (n=61) residing in Goiânia and Fortaleza, Brazil. Blood was incubated with M. Read More

    Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK.
    PLoS Negl Trop Dis 2017 Jan 26;11(1):e0005186. Epub 2017 Jan 26.
    Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, AX Building, University of Surrey, Guildford, Surrey, United Kingdom.
    We have examined the remains of a Pilgrim burial from St Mary Magdalen, Winchester. The individual was a young adult male, aged around 18-25 years at the time of death. Radiocarbon dating showed the remains dated to the late 11th-early 12th centuries, a time when pilgrimages were at their height in Europe. Read More

    Expansion and productive HIV-1 infection of Foxp3 positive CD4 T cells at pleural sites of HIV/TB co-infection.
    J Clin Exp Immunol 2016 31;1(1). Epub 2016 Oct 31.
    Division of Infectious Diseases, Case Western Reserve University, Cleveland OH; Veterans Affairs Medical Center, Cleveland, OH.
    Background: CD4 T-cells expressing Foxp3 are expanded systemically during active tuberculosis (TB) regardless of HIV-1 co-infection. Foxp3(+) CD4 T cells are targets of HIV-1 infection. However, expansion of HIV-1 infected Foxp3(+) CD4 T cells at sites of HIV/TB co-infection, and whether they contribute to promotion of HIV-1 viral activity is not known. Read More

    Isoniazid preventive treatment among child contacts of adults with smear-positive tuberculosis in The Gambia.
    Public Health Action 2016 Dec;6(4):226-231
    Vaccines and Immunity Theme, Medical Research Council Unit-The Gambia, Banjul, The Gambia ; Centre for International Child Health, Academic Department of Paediatrics, Imperial College London, London, UK.
    Setting: Greater Banjul area of The Gambia. Objectives: To evaluate uptake, adherence and completion of treatment among tuberculosis (TB) exposed children in The Gambia when isoniazid preventive treatment (IPT) is delivered at home Design: Child (age <5 years) contacts of adults with smear-positive TB were prospectively enrolled. Following symptom screening, tuberculin skin testing and clinical evaluation where indicated, those without disease were placed on daily isoniazid, provided monthly at home. Read More

    Pilot implementation of a contact tracing intervention for tuberculosis case detection in Kisumu County, Kenya.
    Public Health Action 2016 Dec;6(4):217-219
    Division of TB Elimination, CDC, Atlanta, Georgia, USA.
    Leveraging an existing community health strategy, a contact tracing intervention was piloted under routine programmatic conditions at three facilities in Kisumu County, Kenya. Data collected during a 6-month period were compared to existing programmatic data. After implementation of the intervention, we found enhanced programmatic contact tracing practices, noting an increase in the proportions of index cases traced, symptomatic contacts referred, referred contacts presenting to a facility for tuberculosis screening, and eligible contacts started on isoniazid preventive therapy. Read More

    Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).
    Expert Opin Ther Pat 2017 Jan 31:1-10. Epub 2017 Jan 31.
    a Worldwide Medicinal Chemistry , Pfizer Worldwide Research & Development , Cambridge , MA , USA.
    Introduction: Leucine-rich repeat kinase 2 (LRRK2) is a member of the Tyrosine Kinase-Like (TKL) branch of the kinome tree and is a multi-domain protein that includes GTPase and kinase activity. While genome-wide association studies (GWAS) has linked LRRK2 with Crohn's disease and leprosy, it has received the greatest attention due to it being implicated as one of the genetic loci associated with autosomal dominant inheritance in Parkinson's disease (PD). Areas covered: In this review, the small molecule patent literature from 2014-2016 with a focus on composition of matter and use patents was surveyed. Read More

    Leprosy with Atypical Skin Lesions Masquerading as Relapsing Polychondritis.
    Case Rep Infect Dis 2016 26;2016:7802423. Epub 2016 Dec 26.
    Department of ENT, Asian Institute of Medical Sciences, Faridabad, India.
    Leprosy can present with a variety of clinical manifestations depending on the immune status of the individual. After dermatological and neurological involvement, rheumatic features specially various forms of arthritis are the third most common manifestation of the disease. We describe a unique case of a 22-year-old patient presenting with external ear involvement mimicking relapsing polychondritis along with inflammatory joint symptoms and skin lesions. Read More

    Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia.
    PLoS Negl Trop Dis 2017 Jan 23;11(1):e0005325. Epub 2017 Jan 23.
    Instituto Colombiano de Medicina Tropical-Universidad CES. Department of Microbiology, Sabaneta, Antioquia, Colombia.
    Leprosy in Colombia is in a stage of post elimination-since 1997, prevalence of the disease is less than 1/10000. However, the incidence of leprosy has remained stable, with 400-500 new cases reported annually, with MB leprosy representing 70% of these case and 10% having grade 2 disability. Thus, leprosy transmission is still occurring, and household contacts (HHCs) of leprosy patients are a population at high risk of contracting and suffering from the effects of the disease during their lifetime. Read More

    IL-12 and IL-23 modulate plasticity of FoxP3(+) regulatory T cells in human Leprosy.
    Mol Immunol 2017 Mar 19;83:72-81. Epub 2017 Jan 19.
    Department of Biochemistry, All India Institute of Medical Sciences, AIIMS, New Delhi, 110029, India; GITAM Institute of Medical Sciences and Research, GITAM University, Rushikonda, Visakhapatnam, 530045, India. Electronic address:
    Leprosy is a bacterial disease caused by M. leprae. Its clinical spectrum reflects the host's immune response to the M. Read More

    Granulomatous & histiocytic dermatitides.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical & Cytological Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. Read More

    Endothelium adhesion molecules ICAM-1, ICAM-2, VCAM-1 and VLA-4 expression in leprosy.
    Microb Pathog 2017 Jan 11;104:116-124. Epub 2017 Jan 11.
    Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil; Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil. Electronic address:
    Leprosy triggers a complex relationship between the pathogen and host immune response. Endothelium plays an important role in this immune response by directly influencing cell migration to infected tissues. The objective of this work is to investigate the possible role of endothelium in M. Read More

    A Complete Profile on Blind-your-eye Mangrove Excoecaria Agallocha L. (Euphorbiaceae): Ethnobotany, Phytochemistry, and Pharmacological Aspects.
    Pharmacogn Rev 2016 Jul-Dec;10(20):123-138
    Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
    Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances. This article provides a comprehensive review of the complete profile of an important mangrove plant Excoecaria agallocha L. (Euphorbiaceae) and elaborately describing the ethnobotany, phytochemistry, and pharmacological properties. Read More

    "I Wasted 3 Years, Thinking It's Not a Problem": Patient and Health System Delays in Diagnosis of Leprosy in India: A Mixed-Methods Study.
    PLoS Negl Trop Dis 2017 Jan 12;11(1):e0005192. Epub 2017 Jan 12.
    State Leprosy Officer/Joint Director of Health Services (Leprosy), Government of Maharashtra, Pune, India.
    Background: Worldwide, leprosy is one of the major causes of preventable disability. India contributes to 60% of global leprosy burden. With increasing numbers of leprosy with grade 2 disability (visible disability) at diagnosis, we aimed to determine risk factors associated with grade 2 disability among new cases and explore patients and providers' perspectives into reasons for late presentation. Read More

    Hospitalized care for MDR-TB in Port Harcourt, Nigeria: a qualitative study.
    BMC Infect Dis 2017 Jan 10;17(1):50. Epub 2017 Jan 10.
    Liverpool School of Tropical Medicine, Liverpool, UK.
    Background: In Nigeria multidrug-resistant tuberculosis (MDR-TB) is prevalent in 2.9% of new TB cases and 14% of retreatment cases, and the country is one of 27 with high disease burden globally. Patients are admitted and confined to one of ten MDR-TB treatment facilities throughout the initial 8 months of treatment. Read More

    Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study.
    Indian J Pharmacol 2016 Nov-Dec;48(6):659-664
    Department of Pharmacology, Venerology and Leprosy, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India.
    Objective: Epidermal dermatophyte infections most commonly manifest as tinea corporis or tinea cruris. Topical azole antifungals are commonly used in their treatment but literature suggests that most require twice-daily application and provide lower cure rates than the allylamine antifungal terbinafine. We conducted a head-to-head comparison of the effectiveness of the once-daily topical azole, sertaconazole, with terbinafine in these infections. Read More

    Prevalence of snoring and the risk of sleep apnea in hospital staff.
    Work 2016 ;55(4):765-772
    Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Untreated Obstructive sleep apnea syndrome (OSAS) as a common breathing sleep disorder results in impaired work performance. The economic burden of untreated OSAS accounts for billions of dollars per year.

    Objective: The aim of this study was to evaluate the prevalence of snoring and the risk of OSAS in healthcare system staff. Read More

    Autophagy Is an Innate Mechanism Associated with Leprosy Polarization.
    PLoS Pathog 2017 Jan 5;13(1):e1006103. Epub 2017 Jan 5.
    Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil.
    Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. IFN-γ primes macrophages for inflammatory activation and induces the autophagy antimicrobial mechanism. Read More

    Spectrum and burden of neglected tropical diseases observed in an infectious and tropical diseases unit in Florence, Italy (2000-2015).
    Intern Emerg Med 2017 Jan 4. Epub 2017 Jan 4.
    Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134, Florence, Italy.
    Neglected tropical diseases (NTDs) are a diverse group of acute and chronic conditions with distinct characteristics that thrive mainly among the poorest populations, almost exclusively in tropical countries. To evaluate the relevance and impact of NTDs in a temperate area, the number and features of patients diagnosed with NTDs at the Infectious and Tropical Diseases Unit (ITDU), Azienda Ospedaliero-Universitaria Careggi, Florence, Italy between 2000 and 2015 were retrospectively reviewed. Overall 289 NTD cases were diagnosed in 283 subjects accounting for 2. Read More

    Morphoea with prominent plasma cell endoneuritis.
    Clin Exp Dermatol 2017 Mar 4;42(2):196-199. Epub 2017 Jan 4.
    Department of Dermatopathology, St Thomas' Hospital, London, UK.
    Morphoea (localized scleroderma) is a cutaneous inflammatory condition characterized by the development of indurated and discoloured plaques. The histological features of morphoea typically include a superficial and deep perivascular and periadnexal chronic inflammatory infiltrate associated with variable degrees of dermal and/or subcutaneous sclerosis. The infiltrate is typically composed of lymphocytes, macrophages and conspicuous plasma cells. Read More

    Patch Test as a Diagnostic Tool in Hand Eczema.
    J Clin Diagn Res 2016 Nov 1;10(11):WC04-WC07. Epub 2016 Nov 1.
    Professor and Head, Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences , Pondicherry, India .
    Introduction: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Read More

    Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study.
    J Clin Diagn Res 2016 Nov 1;10(11):EC13-EC16. Epub 2016 Nov 1.
    Assistant Professor, Department of Pathology, ACPM Medical College , Dhule, Maharashtra, India .
    Introduction: Infectious granulomatous dermatitis is a distinctive entity of chronic inflammation. Recognizing the aetiology of granulomatous lesion is challenging to the dermatopathologist. The definitive diagnosis of the granulomatous lesions of skin with identification of aetiological agent is very essential for specific treatment and an appropriate desirable outcome. Read More

    Importance of the α10 helix for DevR activation: A road map for screening inhibitors against DevR-mediated dormancy of Mycobacterium tuberculosis.
    Int J Mycobacteriol 2016 Dec 11;5 Suppl 1:S92-S93. Epub 2016 Nov 11.
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:
    Objective/background: Bacterial persistence is the hallmark of tuberculosis (TB) and poses the biggest threat to the success of any antitubercular drug regimen. The DevR/DosR dormancy regulator of Mycobacterium tuberculosis belongs to the NarL subfamily of response regulators and is essential for M. tuberculosis persistence in macaque models of TB. Read More

    1 OF 514