29,012 results match your criteria Leprosy


Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic.

Int Rev Immunol 2021 May 7:1-14. Epub 2021 May 7.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine that was developed about 100 years ago by Albert Calmette and Camille Guérin. Many countries have been using the vaccine for decades against tuberculosis (TB). The World Health Organization (WHO) recommends a single dose of BCG for infants in TB endemic as well as leprosy high risk countries, and globally almost 130 million infants are vaccinated yearly. Read More

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Infliximab in leprosy type 1 reaction: a case report.

Int J Dermatol 2021 May 6. Epub 2021 May 6.

Department of Dermatology, Andrée Rosemon Hospital, Cayenne, French Guiana.

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Role of shear wave elastography in treatment follow-up of leprosy neuropathy.

J Ultrasound 2021 May 6. Epub 2021 May 6.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Purpose: Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neuropathy. Our purpose was to evaluate the role of shear wave elastography in assessing stiffness changes within the ulnar nerve during treatment of leprosy. Read More

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Atrophia Maculosa Varioliformis Cutis: A Rare Case Report.

Indian Dermatol Online J 2021 Mar-Apr;12(2):346-348. Epub 2020 Sep 28.

Department of Dermatology, Venereology and Leprosy, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India.

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September 2020

Newer Signs in Dermatology [2016-2020].

Indian Dermatol Online J 2021 Mar-Apr;12(2):342-345. Epub 2020 Sep 28.

Department of Dermatology, Venereology and Leprosy, Jawahar Lal Medical College and Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India.

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September 2020

Segmental Zoster Paresis of Lower Thoracic Segment Presenting as Pseudohernia-A Report of Three Cases.

Indian Dermatol Online J 2021 Mar-Apr;12(2):324-326. Epub 2021 Feb 22.

Department of Dermatology, Venereology and Leprosy, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Segmental zoster paresis is characterized by focal motor weakness affecting the myotome corresponding to the dermatomal distribution of the rash. Clinically, it presents as pseudohernia when it involves abdominal wall muscles. We report three cases of segmental zoster paresis presenting as pseudohernia of abdominal wall. Read More

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February 2021

Pleomorphic and Widespread Lesions of Phaeohyphomycosis in a Leprosy Patient on Corticosteroid.

Indian Dermatol Online J 2021 Mar-Apr;12(2):319-323. Epub 2021 Mar 2.

Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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Basidiobolomycosis: Case Report and Literature Overview.

Indian Dermatol Online J 2021 Mar-Apr;12(2):307-311. Epub 2021 Mar 2.

Department of Dermatology, Venereology and Leprosy, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India.

Basidiobolomycosis or subcutaneous zygomycosis or subcutaneous phycomycosis is a chronic granulomatous infection of skin and subcutaneous tissue, caused by a saprophytic filamentous fungus, , clinically characterized by firm, painless subcutaneous swelling with smooth and rounded edges. Histopathological features include the peculiar Splendore-Hoeppli phenomenon. Culture on Sabouraud dextrose agar shows creamy white, heaped up, and furrowed colonies. Read More

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Nevus Unius Lateris with Bilateral Oral Mucosal Lesions: An Unusual Presentation.

Indian Dermatol Online J 2021 Mar-Apr;12(2):302-306. Epub 2021 Feb 22.

Department of Dermatology, Venereology and Leprosy, Government Medical College, Amritsar, Punjab, India.

Verrucous epidermal nevi (VEN) are cutaneous hamartomas characterized by keratinocytic hyperplasia. Majority are linear in distribution and tend to follow the Blaschko lines; however, some may have zosteriform (segmental) or systematized distribution involving widespread areas of skin. The systematized ones are further classified into "" when one-half of the body is affected, and "" showing bilateral distribution, both being the uncommon forms. Read More

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February 2021

Leprosy in Elderly and Children among New Cases - A 3-Year Retrospective Study.

Indian Dermatol Online J 2021 Mar-Apr;12(2):294-297. Epub 2021 Mar 2.

Department of Dermatology, Navodaya Medical College, Raichur, Karnataka, India.

Background: Leprosy occurs in all age groups, with adults constituting the majority. However, leprosy in children always drew the attention of epidemiologists as a guide to transmission of leprosy. With increasing life expectancy and decreasing prevalence of leprosy, there is going to be a significant rise of leprosy among elderly in India. Read More

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Entodermoscopy Update: A Contemporary Review on Dermoscopy of Cutaneous Infections and Infestations.

Indian Dermatol Online J 2021 Mar-Apr;12(2):220-236. Epub 2021 Mar 2.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Infectious cutaneous diseases are very common, especially in certain geographic and tropical regions. Sometimes they may simulate other dermatoses, ordering verification of diagnosis with particular investigations. Dermoscopy is among one of the most important tools readily available in the outpatient setting for the dermatologist to confirm the diagnosis. Read More

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Polymorphous Light Eruption- An Indian Scenario.

Indian Dermatol Online J 2021 Mar-Apr;12(2):211-219. Epub 2021 Mar 2.

Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences, Pondicherry, India.

Polymorphous light eruption (PMLE) is the most common, idiopathic, acquired photodermatosis, characterized by abnormal, recurrent, and delayed reaction to sunlight. Polymorphous light eruption is common worldwide but the morphology, distribution, and pigmentary changes are unique in Indian skin which is discussed in this review. The prevalence of PMLE is around 10-20% in the general population. Read More

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Evaluation of the 2016-2020 regional tuberculosis response framework, WHO Western Pacific Region.

Bull World Health Organ 2021 May 2;99(5):330-341A. Epub 2021 Mar 2.

WHO Collaborating Centre for Tuberculosis and the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.

Objective: To assess the implementation of the in countries and areas in the World Health Organization Western Pacific Region.

Methods: We used a mixed methods approach to assess the framework's measurable and perceived impact. We conducted an analysis of national tuberculosis strategic plans, a cross-sectional survey of senior staff of tuberculosis programmes, key informant interviews and some country case studies. Read More

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Evaluation of a self-help intervention to promote the health and wellbeing of marginalised people including those living with leprosy in Nepal: a prospective, observational, cluster-based, cohort study with controls.

BMC Public Health 2021 May 6;21(1):873. Epub 2021 May 6.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Background: People affected by leprosy are at increased risk of ulcers from peripheral nerve damage. This in turn can lead to visible impairments, stigmatisation and economic marginalisation. Health care providers suggest that patients should be empowered to self-manage their condition to improve outcomes and reduce reliance on services. Read More

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Digital adherence technology for tuberculosis treatment supervision: A stepped-wedge cluster-randomized trial in Uganda.

PLoS Med 2021 May 6;18(5):e1003628. Epub 2021 May 6.

Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda.

Background: Adherence to and completion of tuberculosis (TB) treatment remain problematic in many high-burden countries. 99DOTS is a low-cost digital adherence technology that could increase TB treatment completion.

Methods And Findings: We conducted a pragmatic stepped-wedge cluster-randomized trial including all adults treated for drug-susceptible pulmonary TB at 18 health facilities across Uganda over 8 months (1 December 2018-31 July 2019). Read More

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A Review on Molecular Mechanisms of Antifungal Resistance in : Update and Recent Advances.

Microb Drug Resist 2021 May 5. Epub 2021 May 5.

Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

is the second frequent etiologic agent of mucosal and invasive candidiasis. Based on the recent developments in molecular methods, has been introduced as a complex composed of , , and . The four main classes of antifungal drugs effective against are pyrimidine analogs (flucytosine), azoles, echinocandins, and polyenes. Read More

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Internal Migration and Leprosy in Shanghai from 2000 to 2019: an Epidemiological Study of New Cases.

Acta Derm Venereol 2021 May 6. Epub 2021 May 6.

Department of infectious Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Massive internal migration from rural to urban areas poses new challenges for leprosy control in Shanghai, China. This retrospective epidemiological study examined new cases of leprosy diagnosed in Shanghai from 2000 to 2019, with emphasis on internal migration cases. Read More

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Leprosy-Induced Hip Arthritis: A Rare Case Report.

J Orthop Case Rep 2020 May-Jun;10(3):71-75

Department of Orthopaedic Surgery, Dr. B.R Ambedkar Central Railway Hospital, Byculla, Mumbai, Maharashtra, India.

Introduction: Leprosy is a chronic granulomatous infection, classically presents with cutaneous and neurological manifestations. Joint involvement in leprosy can present as acute symmetrical or chronic polyarthritis with or without tenosynovitis resembling rheumatoidarthritis.

Case Report: We report a rare case of lepromatous hip arthritis in a 32-year-old male, known case of leprosytenosynovitis and symmetrical polyarthritis of hands and feet 3 weeks after appearance of typical cutaneous lesion. Read More

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Dermoscopy in Leprosy: A Clinical and Histopathological Correlation Study.

Dermatol Pract Concept 2021 Mar 12;11(2):e2021032. Epub 2021 Apr 12.

Department of Dermatology, Venereology and Leprosy, Government Medical College, Kota, India.

Background: Leprosy, an insidious infectious granulomatous disease, is diagnosed traditionally through clinical examination coupled with skin smears and histopathology. It has myriad clinical presentations that pose diagnostic challenges. Lately, dermoscopy has emerged as a rapid, noninvasive diagnostic modality for many dermatoses. Read More

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Sphingomyelin liposome bearing whole lysate antigens induce strong Th2 immune response in BALB/c mice.

Iran J Basic Med Sci 2021 Feb;24(2):222-231

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Whole lysate antigens (WLL) has been shown to be effective to tackle leishmaniasis in murine models. Although liposomes can be considered as promising vaccines, the activity of phospholipase-A (PLA) in WLL, breeds difficulties to preparing stable liposomal WLL. One strategy to overcome this shortcoming is to use lipids such as sphingomyelin (SM) which is resistant against PLA. Read More

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February 2021

Incidence and demographic characteristics of Syrian Civil War-related amputations: A multi-center study.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):48-55. Epub 2021 Mar 4.

Istanbul Leprosy, Skin and Venereal Diseases Hospital, Istanbul, Turkey.

Objectives: The aim of this study was to identify the causes, levels, and rates of amputations performed in civilians during the Syrian Civil War and to present epidemiological data of the amputees.

Patients And Methods: Between August 2017 and February 2019, a total of 363 amputations of 307 amputees (266 males, 41 females; mean age 29.9±13. Read More

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Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.

BMC Public Health 2021 May 4;21(1):859. Epub 2021 May 4.

Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop US1-1, Atlanta, GA, 30030, USA.

Background: The Ministry of Health Zambia recommends tuberculosis preventive treatment (TPT) with 6 months daily isoniazid for all people living with human immunodeficiency virus (HIV) after ruling out active tuberculosis disease. We sought to estimate the percentage of people living with HIV who progress through each stage of the tuberculosis case-finding and prevention cascade in two provinces with the highest tuberculosis burden in Zambia.

Methods: In this cross-sectional survey, we used a two-stage cluster sampling method. Read More

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Taxonomy, Population Structure and Genetic Diversity of Iranian Leishmania Strains of Cutaneous and Visceral Leishmaniasis.

Acta Parasitol 2021 May 3. Epub 2021 May 3.

Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Despite the broad distribution of leishmaniasis in Iran, there is a little genetic information about the causative agents and epidemiological status of the disease. Genetic diversity of the parasite is suggested to be one of the factors, which influences the clinical manifestations of the disease. In this study, we investigated the genetic variations, population structure, and evolutionary history of Leishmania species from endemic foci of Iran. Read More

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Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center.

PLoS Negl Trop Dis 2021 May 3;15(5):e0009382. Epub 2021 May 3.

Souza Araújo Outpatient Clinic, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

The World Health Organization has raised concerns about the increasing number of Hansen disease (HD) relapses worldwide, especially in Brazil, India, and Indonesia that report the highest number of recurrent cases. Relapses are an indicator of MDT effectiveness and can reflect Mycobacterium leprae persistence or re-infection. Relapse is also a potential marker for the development or progression of disability. Read More

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Leprosy as a Diagnostic Challenge in the United States.

Skinmed 2021 1;19(2):137-141. Epub 2021 Apr 1.

Department of Dermatology, Mayo Clinic, Jacksonville, FL.

A 63-year-old woman from Central Florida presented to an outside clinic with a 2-year history of a progressive, asymptomatic cutaneous eruption and arthralgias. Her past medical history was significant for reported seronegative rheumatoid arthritis, for which adalimumab, methotrexate, and low-dose prednisone therapy were initiated 5 years prior. The skin eruption occurred shortly after a 4-week hospitalization during which these medications were withheld. Read More

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Acral Amelanotic Melanoma in Fitzpatrick Type IV Skin.

Skinmed 2021 1;19(2):134-136. Epub 2021 Apr 1.

Department of Dermatology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

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Epistaxis Runs in the Family.

Oman Med J 2021 Mar 31;36(2):e253. Epub 2021 Mar 31.

Department of Dermatology, Venereology, and Leprosy, R.G. Kar Medical College, Kolkata, India.

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Erythromelanosis follicularis faciei et colli.

Paediatr Child Health 2021 Jun 3;26(3):133-134. Epub 2020 Apr 3.

Department of Dermatology, Venereology, and Leprosy, R.G.Kar Medical College, Kolkata, West Bengal, India.

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Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation in -Infected Monocyte-Derived Macrophages With Low Multiplicity of Infection.

Front Immunol 2021 16;12:647832. Epub 2021 Apr 16.

Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

Leprosy is a disease with a clinical spectrum of presentations that is also manifested in diverse histological features. At one pole, lepromatous lesions (L-pole) have phagocytic foamy macrophages heavily parasitized with freely multiplying intracellular . At the other pole, the presence of epithelioid giant cells and granulomatous formation in tuberculoid lesions (T-pole) lead to the control of replication and the containment of its spread. Read More

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