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    1 OF 532

    Is disability in leprosy still a burden? A cross-sectional study in a rural block in Tamil Nadu, India.
    Trans R Soc Trop Med Hyg 2018 Mar 16. Epub 2018 Mar 16.
    SRM Medical College Hospital and Research Centre, Potheri, Kancheepuram District, Tamil Nadu, India.
    Background: Leprosy, a disease caused by Mycobacterium leprae, is an important cause of preventable disability.

    Methods: The present cross-sectional study was undertaken among leprosy-affected persons in a rural block in Kanchipuram District, Tamil Nadu, India in the year 2013. The sample included treatment completed leprosy affected persons ≥18 y of age. Read More

    Blood coagulation abnormalities in multibacillary leprosy patients.
    PLoS Negl Trop Dis 2018 Mar 22;12(3):e0006214. Epub 2018 Mar 22.
    Lab. of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
    Background: Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae infection. In 2016, more than 200,000 new cases of leprosy were detected around the world, representing the most frequent cause of infectious irreversible deformities and disabilities.

    Principal Findings: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients. Read More

    Work and Leprosy: women in their pains, struggles and toils.
    Rev Bras Enferm 2018 ;71(suppl 1):660-667
    Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Postgraduate Program in Nursing in Public Health. Ribeirão Preto, São Paulo, Brazil.
    Objective: To analyze the interference of leprosy in women's life regarding work and daily life activities.

    Method: Exploratory qualitative study developed from semi-structured interviews and with the use of field diaries. The strategy of the organization of data was a thematic analysis of content and referential of the work process in health and gender. Read More

    Drug targeted virtual screening and molecular dynamics of LipU protein of Mycobacterium tuberculosis and Mycobacterium leprae.
    J Biomol Struct Dyn 2018 Mar 20:1-38. Epub 2018 Mar 20.
    a Department of Biotechnology , Panjab University , BMS Block-1, South Campus, Chandigarh.
    The lipolytic protein LipU was conserved in mycobacterium sp. including M. tuberculosis (MTB LipU) and M. Read More

    Coinfection of leprosy and tuberculosis.
    BMJ Case Rep 2018 Mar 15;2018. Epub 2018 Mar 15.
    Department of Pathology, Grande International Hospital, Kathmandu, Nepal.
    Leprosy and tuberculosis (TB) are endemic to India, however, their coinfection is not frequently encountered in clinical practice. Here, we report a 32-year-old female patient who presented with a history of high-grade intermittent fever, cough and painless skin lesions since a month, along with bilateral claw hand (on examination). The haematological profile was suggestive of anaemia of chronic disease, chest radiograph showed consolidation, sputum smears were positive for Mycobacterium tuberculosis, and skin slit smear confirmed leprosy. Read More

    The leprosarium of Saint-Thomas d'Aizier: The cementochronological proof of the medieval decline of Hansen disease in Europe?
    Int J Paleopathol 2016 Dec 20;15:140-151. Epub 2015 Mar 20.
    Centre Michel de Bouärd, CNRS, UMR 6273, Université de Caen, Esplanade de la paix, 14032 Caen Cedex, France. Electronic address:
    This study compares the adult survivorship profiles of people interred in the Saint-Thomas d'Aizier leprosarium, estimated by cementochronology, to eight archaeological series in northern France dated from Late Antiquity to the Late Middle Ages, periods of significant visibility for Hansen's disease (leprosy). The goals are to understand the impact of leprosy on various social groups and to explore the cause of leprosy's decline by analyzing male and female fertility. Survival rates differed between medieval leprosy-free sites and the Saint-Thomas d'Aizier leprosarium, although this difference was statistically significant only for the female leprosarium sample. Read More

    Age-at-death estimation of pathological individuals: A complementary approach using teeth cementum annulations.
    Int J Paleopathol 2016 Dec 26;15:120-127. Epub 2014 Apr 26.
    Unité de Taphonomie Médico-Légale, Institut de Médecine Légale de Lille, Université de Lille 2, France.
    Bioarchaeologists rely on accurate estimations of age-at-death. Clearly, some pathological conditions are associated with gross morphological changes in the skeleton that could impact the effectiveness of age-at-death estimation (i.e. Read More

    Begotten of Corruption? Bioarchaeology and "othering" of leprosy in South Asia.
    Int J Paleopathol 2016 Dec 18;15:1-9. Epub 2016 Sep 18.
    Associate professor of anthropology, Appalachian State University, Boone, NC, USA. Electronic address:
    Leprosy is strongly stigmatized in South Asia, being regarded as a manifestation of extreme levels of spiritual pollution going back through one or more incarnations of the self. Stigma has significant social consequences, including surveillance, exclusion, discipline, control, and punishment; biologically speaking, internalized stigma also compounds the disfigurement and disability resulting from this disease. Stigma results from an othering process whereby difference is recognized, meaning is constituted, and eventually, sufferers may be negatively signified and marked for exclusion. Read More

    Biological and social implications of a medieval burial from Cyprus for understanding leprosy in the past.
    Int J Paleopathol 2014 Mar 12;4:17-24. Epub 2013 Nov 12.
    School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287-2402, USA. Electronic address:
    An early 15th-century burial from a basilica at Polis Chrysochous provides the first archaeological evidence of leprosy in Cyprus, extending the temporal depth and illuminating the biological and social history of this disease on the island. The skeletal remains of a young adult female (age 20-34 years) display pathognomonic features of lepromatous leprosy including maxillary alveolar resorption with antemortem loss of all but one incisor, remodeling of the margin of the nasal sill and resorption of the anterior nasal spine, with diaphyseal remodeling of hand and foot phalanges and the distal third through fifth metatarsals of both feet. Periosteal reaction on distal tibiae and the majority of both fibulae demonstrates tracking of inflammation from the feet to lower legs. Read More

    Severe erosive polyarthritis in a human skeleton dated to the early modern period of Japan.
    Int J Paleopathol 2015 Mar 6;8:10-18. Epub 2014 Nov 6.
    Research Institute, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-machi, Obu City, Aichi, Japan.
    A human skeleton apparently afflicted with severe polyarthritis was unearthed from an early modern grave at the Tamukai site in the northernmost part of Honshu in Japan. The bones, likely from a late middle-aged male, showed severe resorptive lesions and ankylosis in many of the peripheral joints. Lesions were found in both bilateral and symmetrical distributions, sometimes accompanied by juxta-articular osteoporosis. Read More

    A contextual study of the medieval hospital and cemetery of St Mary Magdalen, Winchester, England.
    Int J Paleopathol 2012 Dec 6;2(4):170-180. Epub 2012 Nov 6.
    Department of Archaeology, University of Winchester, Hampshire SO22 4NR, United Kingdom. Electronic address:
    This paper examines the osteoarchaeological evidence for leprosy in 38 skeletons excavated from the north cemetery of the hospital of St Mary Magdalen, Winchester (founded by the late 11th century) between 2009 and 2011. This cemetery, to the north of the medieval chapel, represents a discrete burial area, separate from the main, more recent cemetery to the south. The analysis indicates skeletal evidence for leprosy in over 85% (33) of the burials. Read More

    Using genes to triangulate the pathophysiology of granulomatous autoinflammatory disease: NOD2, PLCG2 and LACC1.
    Int Immunol 2018 Mar 12. Epub 2018 Mar 12.
    Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.
    The intersection of granulomatosis and autoinflammatory disease is a rare occurrence that can be generally subdivided into purely granulomatous phenotypes and disease spectra that are inclusive of granulomatous features. NOD2 (nucleotide binding oligomerization domain containing 2)-related disease, which includes Blau syndrome and early onset sarcoidosis, is the prototypic example of granulomatous inflammation in the context of monogenic autoinflammation. Granulomatous inflammation has also been observed in two related autoinflammatory diseases caused by mutations in PLCG2 (phospholipase C gamma 2). Read More

    [Leprosy trends in children under 15 years of age in Brazil, 2001-2016].
    Cad Saude Publica 2018 Mar 12;34(3):e00101817. Epub 2018 Mar 12.
    Faculdade de Enfermagem, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
    The aim of this study was to analyze trends in the detection rate of leprosy in children under 15 years of age in Brazil from 2001 to 2016. A time series study used the Prais-Winsten procedure for generalized linear regression analysis, with significance set at 5%. The mean detection rate was 5. Read More

    Resistance to anti leprosy drugs in multi-bacillary leprosy: A cross sectional study from a tertiary care centre in eastern Uttar Pradesh, India.
    Indian J Dermatol Venereol Leprol 2018 Mar 14. Epub 2018 Mar 14.
    Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
    Background: WHO MDT is the main drug regimen for treating leprosy and has been used for more than three decades. Many cases of relapse of leprosy have been reported, which points towards the emergence of drug resistance with the antileprotic drugs.

    Objectives: To find the resistance with the antileprotic drugs by detecting the mutations in drug resistance determining region of the rpoB, folP1 and gyrA genes of Mycobacterium leprae. Read More

    Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application.
    Front Immunol 2018 26;9:308. Epub 2018 Feb 26.
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
    Tuberculosis (TB) and leprosy still represent significant public health challenges, especially in low- and lower middle-income countries. Both poverty-related mycobacterial diseases require better tools to improve disease control. For leprosy, there has been an increased emphasis on developing tools for improved detection of infection and early diagnosis of disease. Read More

    Dietary diversity and poverty as risk factors for leprosy in Indonesia: A case-control study.
    PLoS Negl Trop Dis 2018 Mar 13;12(3):e0006317. Epub 2018 Mar 13.
    Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands.
    Background: Poverty has long been considered a risk factor for leprosy and is related to nutritional deficiencies. In this study, we aim to investigate the association between poverty-related diet and nutrition with leprosy.

    Methodology/principal Findings: In rural leprosy-endemic areas in Indonesia, we conducted a household-based case-control study using two controls for each case patient (100 recently diagnosed leprosy patients and 200 controls), matched for age and gender. Read More

    Socioeconomic benefit to individuals of achieving 2020 targets for four neglected tropical diseases controlled/eliminated by innovative and intensified disease management: Human African trypanosomiasis, leprosy, visceral leishmaniasis, Chagas disease.
    PLoS Negl Trop Dis 2018 Mar 13;12(3):e0006250. Epub 2018 Mar 13.
    Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
    Background: The control or elimination of neglected tropical diseases (NTDs) has targets defined by the WHO for 2020, reinforced by the 2012 London Declaration. We estimated the economic impact to individuals of meeting these targets for human African trypanosomiasis, leprosy, visceral leishmaniasis and Chagas disease, NTDs controlled or eliminated by innovative and intensified disease management (IDM).

    Methods: A systematic literature review identified information on productivity loss and out-of-pocket payments (OPPs) related to these NTDs, which were combined with projections of the number of people suffering from each NTD, country and year for 2011-2020 and 2021-2030. Read More

    Evaluation of Association Between the Serum Levels of MMP-9 and MMP-9/TIMPs With Soluble Forms of Selectins and Itching Induced by Sulfur Mustard.
    Iran J Pathol 2017 27;12(3):257-264. Epub 2017 Jan 27.
    Dept. of Immunology, Tarbiat Moddares University, Tehran, Iran.
    Background & Objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP)-9 and their endogenous inhibitors, and serum levels of soluble forms of selectins (sL-, sP-, and sE-selectins) as adhesion molecules involved in the development of different inflammatory reactions. Read More

    Mutation in the Squalene epoxidase gene ofandassociated with allylamine resistance.
    Antimicrob Agents Chemother 2018 Mar 12. Epub 2018 Mar 12.
    Department of Medical Microbiology, Department of Dermatology, Venerology and Leprosy, Postgraduate Institute of Medical Education and Research, Chandigarh, India, and
    Dermatophytosis, the commonest superficial fungal infection, has gained recent attention due to its change of epidemiology and treatment failures. Despite availability of several effective antifungal agents against dermatophytes, the incidence of chronic infection, re-infection and treatment failures are on the rise.andare the two frequent clinical isolates in India. Read More

    Protective effect of Sesbania grandiflora on acetic acid induced ulcerative colitis in mice by inhibition of TNF-α and IL-6.
    J Ethnopharmacol 2018 Mar 9. Epub 2018 Mar 9.
    Dadasaheb Balpnade college of Pharmacy, Department of Pharmaceutical Quality Assurance, Near Swami Samarth Dham Mandir, Manewada road, Besa, Nagpur-440 034, Maharashtra, India. Electronic address:
    Ethnopharmacological Relevance: The plant Sesbania grandiflora (Linn) belonging to the family Fabaceae is commonly known as sesbania, agathi, and katurai. The plant is accredited for alleviating a spectrum of ailments including inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, bronchitis, convulsion and anxiety. It is also used as antitumour, anthelmintic, and laxatives in Ayurveda and Siddha system of Indian traditional medicine. Read More

    Palmoplantar Lesions of Lichen Planus.
    Indian J Dermatol 2018 Jan-Feb;63(1):57-61
    Department of Dermatology, STD and Leprosy, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
    Introduction: Palmoplantar lesions of lichen planus (LP) are uncommon and may not always have classical clinical features of LP. A variety of morphological types has been described in literature.

    Aim And Objectives: The aim was to study and classify the clinical variants into distinct easily recognisable categories for quick recognition and early treatment initiation. Read More

    A Comparative Study of Efficacy and Safety of Eberconazole versus Terbinafine in Patients of Tinea Versicolor.
    Indian J Dermatol 2018 Jan-Feb;63(1):53-56
    Department of Skin, VD and Leprosy, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India.
    Background: Tinea versicolor (TV) is characterised by the appearance of maculosquamous lesions sometimes associated with mild erythema and pruritus in characteristic areas of the body. Eberconazole and terbinafine though drugs of different classes provide both mycological and clinical cure.

    Aim: This study aims to compare the efficacy and safety of eberconazole versus terbinafine in patients of TV. Read More

    Clinical and Histopathological Response to Multidrug Therapy in Paucibacillary Leprosy at the end of 6 Months: A Prospective Observational Study from Eastern India.
    Indian J Dermatol 2018 Jan-Feb;63(1):47-52
    Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.
    Background: At present, the WHO recommends fixed duration multidrug therapy (FD-MDT) for the treatment of leprosy, in which treatment is provided for a fixed duration regardless of clearance of skin lesions or bacterial status of the patient. There is divided opinion regarding the efficacy of FD-MDT; especially for paucibacillary Hansen's disease, in which treatment is provided for 6 months. In addition, there is a paucity of literature on clinical and histopathological features of treated leprosy. Read More

    Cutaneous Adverse Reactions of Chemotherapy in Cancer Patients: A Clinicoepidemiological Study.
    Indian J Dermatol 2018 Jan-Feb;63(1):41-46
    Department of Dermatology, Venereology and Leprosy, S. P. Medical College, Bikaner, Rajasthan, India.
    Background: The diagnosis of cutaneous adversities in the cancer patient is especially difficult, given the complexity of their illness and combination protocols used for the treatment. The present study was undertaken to know the spectrum of cutaneous adversities in patients undergoing chemotherapy and the drug(s) most commonly associated with it.

    Materials And Methods: A total of 1000 patients with malignancies under chemotherapy in the oncology ward and outpatient department were screened in this observational study from January 2013 to February 2015. Read More

    Quantitative evaluation of maxillary bone deformation by computed tomography in patients with leprosy.
    PLoS Negl Trop Dis 2018 Mar 9;12(3):e0006341. Epub 2018 Mar 9.
    National Sanatorium Hoshizuka-Keiaien, Kanoya, Kagoshima, Japan.
    Background: Facial deformation as a sequela of leprosy is caused not only by a saddle nose but also by regression of the maxilla, as well documented in paleopathological observations of excavated skeletal remains of patients with leprosy. However, maxillary changes in living patients have been evaluated only by the subjective visual grading. Here, we attempted to evaluate maxillary bone deformation in patients with leprosy using three-dimensional computed tomography (3D-CT). Read More

    Reactive perforating leprosy, erythema multiforme-like reactions, sweet's syndrome-like reactions as atypical clinical manifestations of Type 2 leprosy reaction.
    Int J Mycobacteriol 2018 Jan-Mar;7(1):97-100
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction. Read More

    Fatal dapsone hypersensitivity syndrome with hypothyroidism and steroid-induced diabetes mellitus.
    Indian J Pharmacol 2017 Sep-Oct;49(5):396-398
    Department of Dermatology, TN Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.
    Dapsone has been part of the World Health Organization multidrug therapy for the treatment of leprosy. While it has been efficacious in the management of leprosy, there are many patients who develop adverse drug reactions to the drug including life-threatening reactions such as dapsone hypersensitivity syndrome (DHS). We report a case of a patient who was prescribed dapsone as part of multidrug therapy for leprosy following which she developed DHS. Read More

    Anti-phospholipid syndrome in seven leprosy patients with thrombotic events on corticosteroid and/or thalidomide regimen: insights on genetic and laboratory profiles.
    Rev Soc Bras Med Trop 2018 Jan-Feb;51(1):99-104
    Divisão de Dermatologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
    Introduction: Corticosteroids and/or thalidomides have been associated with thromboembolism events (TBE) in multibacillary (MB) leprosy. This report aimed to determine genetic and laboratory profiles associated with leprosy and TBE.

    Methods: Antiphospholipid antibodies (aPL), coagulation-related exams, prothrombin and Leiden's factor V mutations, and ß2-glycoprotein-I (ß2GPI) Val247Leu polymorphism were assessed. Read More

    Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy.
    Mem Inst Oswaldo Cruz 2018 26;113(5):e170467. Epub 2018 Feb 26.
    Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.
    BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities. Antibodies against several Mycobacterium leprae antigens have, however, shown value as diagnostic and/or prognostic markers. OBJECTIVES The objective of this study was to evaluate serum immunoglobulin (Ig) IgM and IgG subclass reactivity against three M. Read More

    Molecular strain typing of(var.) using non-transcribed spacer region as a molecular marker.
    Indian J Med Res 2017 Nov;146(5):636-641
    Department of Microbiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Chennai, India.
    Background & Objectives: : Dermatophytes are keratinophilic fungi that infect keratinized tissues of human and animal origin. Trichophyton mentagrophytes is considered to be a species complex composed of several strains, which include both anthropophiles and zoophiles. Accurate discrimination is critical for comprehensive understanding of the clinical and epidemiological implications of the genetic heterogeneity of this complex. Read More

    Protective effect of antigen excess immune complex in guinea pigs infected with.
    Indian J Med Res 2017 Nov;146(5):629-635
    Department of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
    Background & Objectives: : Immune complexes (ICs) play a crucial role which can either be beneficial or pathological to the host. Involvement of circulating immune complexes (CICs) has been shown in tuberculosis (TB) cases (adults and neonates form), but its immunomodulatory effect has not been studied in vivo. Hence, this study was carried out to understand and explore the prognostic therapeutic potential of CICs on the host immune system in guinea pigs animal TB model. Read More

    National sample survey to assess the new case disease burden of leprosy in India.
    Indian J Med Res 2017 Nov;146(5):585-605
    ICMR-National Institute of Medical Statistics, New Delhi, India.
    A national sample survey of leprosy was undertaken in partnership with Indian Council of Medical Research (ICMR) institutions, National Leprosy Eradication Programme (NLEP), Panchayati Raj members, and treated leprosy patients to detect new cases of leprosy in India. The objectives of the survey were to estimate the new leprosy case load; record both Grade 1 and Grade 2 disabilities in the new cases; and to assess the magnitude of stigma and discrimination prevalent in the society. A cluster based, cross-sectional survey involving all States was used for the door-to-door survey using inverse sampling methodology. Read More

    Evaluation of safety tool for ambulatory leprosy patients at risk of adverse outcome.
    Trop Dis Travel Med Vaccines 2018 2;4. Epub 2018 Mar 2.
    4Tropical Disease Unit, Toronto General Hospital, 200 Elizabeth Street, 13-EN218, Toronto, ON M5G 2C4 Canada.
    Background: Leprosy is a potentially debilitating disease of the skin and nerves that requires a complex management approach consisting of laboratory monitoring, screening for factors that will adversely affect outcome with corticosteroids, engagement of allied health services, and prolonged follow-up. Given the complexities of leprosy management, a safety tool was developed and implemented in the Tropical Disease Unit at Toronto General Hospital. Our objective was to evaluate the utility of the tool using a retrospective chart review. Read More

    A Rare Case Report of Toxic Epidermal Necrolysis due to Ofloxacin.
    Curr Drug Saf 2018 Mar 2. Epub 2018 Mar 2.
    Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar - 364001 (Gujarat), India.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet uncleared. A 45-year-old male patient by chance on re-exposure to Ofloxacin developed severe cutaneous adverse drug reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN were lead him to death. Read More

    Cytokine profile (IL-2, IL-6, IL-17, IL-22, and TNF-α) in vitiligo-New insight into pathogenesis of disease.
    J Cosmet Dermatol 2018 Mar 4. Epub 2018 Mar 4.
    Department of Biochemistry, Dr. Ram Manohar Lohia Hospital and PGIMER, New Delhi, India.
    Background: Vitiligo is an autoimmune disease associated with alteration in levels of various cytokines. However, there are very few studies in this regard.

    Objectives: To assess the serum levels of cytokines secreted by Th1 (IL-2, TNF-α), Th2 (IL-6), and Th17 cells (IL-17, IL-22) in patients with localized vitiligo and generalized vitiligo and to correlate their levels with the extent, duration, and activity of disease. Read More

    Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response.
    Biochem Biophys Res Commun 2018 03 27;497(4):1104-1109. Epub 2018 Feb 27.
    Genome Institue of Singapore, Singapore. Electronic address:
    As a protein with complex domain structure and roles in kinase, GTPase and scaffolding, LRRK2 is believed to be an important orchestration node leading to several cascades of signal transduction rather than one specific pathway. LRRK2 variants were found to be associated with Parkinson's disease, Crohn's disease and leprosy. Here we disrupt LRRK2 in zebrafish and found hyperactivity rather than hypoactivity in adult zebrafish mutants. Read More

    Complement C1q expression in Erythema nodosum leprosum.
    PLoS Negl Trop Dis 2018 Mar 2;12(3):e0006321. Epub 2018 Mar 2.
    London School of Hygiene and Tropical Medicine, Faculty of Infectious Tropical Diseases, London, United Kingdom.
    Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction. Read More

    Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-2015.
    Clin Microbiol Infect 2018 Feb 26. Epub 2018 Feb 26.
    Global Leprosy Programme, WHO Regional Office for South-East Asia, New Delhi, India.
    Objectives: antimicrobial resistance (AMR) is a priority for surveillance in bacterial infections. For leprosy, AMR could not be assessed so far since Mycobacterium leprae does not grow in vitro. We aim to obtain AMR data using molecular detection of resistance genes and to conduct a prospective open survey of resistance to antileprosy drugs in endemic countries through a WHO surveillance network. Read More

    Tegumentary leishmaniasis and coinfections other than HIV.
    PLoS Negl Trop Dis 2018 Mar 1;12(3):e0006125. Epub 2018 Mar 1.
    Department of Public Health, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
    Background: Tegumentary leishmaniasis (TL) is a disease of skin and/or mucosal tissues caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which may influence the clinical outcome of TL.

    Methodology And Principal Findings: This review focuses on the frequency of TL coinfections in human populations, interactions between Leishmania and other pathogens in animal models and human subjects, and implications of TL coinfections for clinical practice. Read More

    Multiple Asymptomatic Juxta-Articular Nodules Mimicking Tuberous-Xanthoma-A Unusual Presentation of Tophaceous Gout.
    J Cutan Aesthet Surg 2017 Oct-Dec;10(4):223-225
    Department of Dermatology, STD and Leprosy, Indira Gandhi E.S.I.C Hospital, Jhilmil, New Delhi.
    Asymptomatic, juxta-articular nodules are an uncommon morphology, which is usually diagnosed as xanthomas, calcinosis cutis or rheumatoid nodules. This study was represented as a case of gout, which is a disorder of purine metabolism resulting in elevation of serum uric acid and deposition of monosodium urate crystals within and around joints and manifests clinically as inflammatory arthritis. Urate crystal deposits have also been found in tendons, ligaments, viscera, and the skin, with the term "tophi" being used for the non-articular deposits. Read More

    Leprosy of the hard palate: A rare case report.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S121-S125
    BDS Student, D Y Patil Dental College, Pimpri, Pune, Maharastra, India.
    Leprosy is a chronic granulomatous infection caused by, a bacillus that presents a peculiar tropism for the skin and peripheral nerves. Leprosy instigates various types of clinical presentation and exerts influence on the patient's immune response. The clinical gamut of leprosy ranges from the tuberculoid form (TT) to the disseminative and progressive lepromatous form (LL). Read More

    A cross-sectional study of variations in the biophysical parameters of skin among healthy volunteers.
    Indian J Dermatol Venereol Leprol 2018 Mar 1. Epub 2018 Mar 1.
    Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
    Background: Biophysical parameters of skin such as trans-epidermal water loss (TEWL), hydration, elasticity, pH, and sebum reflects it functional integrity. Advances in technology have made it possible to measure these parameters by non-invasive methods. These parameters are useful for the prediction of disease and its prognosis. Read More

    Leprosy and gender in Brazil: trends in an endemic area of the Northeast region, 2001-2014.
    Rev Saude Publica 2018 26;52:20. Epub 2018 Feb 26.
    Departamento de Saúde Comunitária, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
    OBJECTIVE To analyze, stratifield by gender, trends of the new case leprosy detection rates in the general population and in children; of grade 2 disability, and of proportion of multibacillary cases, in the state of Bahia, Brazil from 2001 to 2014. METHODS A time series study based on leprosy data from the National Information System for Notifiable Diseases. The time trend analysis included Poisson regression models by infection points (Joinpoint) stratified by gender. Read More

    Serum Levels of Migration Inhibitory Factor (MIF) andExpression of MIF and Its Receptor CD74 in Lepromatous Leprosy Patients: A Preliminary Report.
    Front Immunol 2018 13;9:246. Epub 2018 Feb 13.
    Centro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
    Leprosy is a chronic disease caused bythat affects the skin and peripheral nerves. It may present as one of two distinct poles: the self-limiting tuberculoid leprosy and the highly infectious lepromatous leprosy (LL) characterized by-specific absence of cellular immune response. The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhance the bactericide activities of macrophages after interaction with its receptor, CD74. Read More

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