27,294 results match your criteria Leprosy


Routine surveillance for the identification of drug resistant Tuberculosis in Tanzania: A cross-sectional study of stakeholders' perceptions.

PLoS One 2019 22;14(2):e0212421. Epub 2019 Feb 22.

Liverpool School of Tropical Medicine, Centre for Applied Health Research and Delivery, Liverpool, United Kingdom.

Background: Routine surveillance is required to monitor the performance of tuberculosis diagnostic programme and is essential for the rapid detection of drug resistance. The main objective of this study was to explore the effectiveness and stakeholder perception of the current routine surveillance system for previously treated tuberculosis cases in Tanzania with a view to identify interventions to improve and accelerate positive patient outcomes.

Methods: A study using quantitative and qualitative methods of data collection including in-depth interviews and focus group discussions with health care service providers was conducted in four regions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212421PLOS
February 2019

Sub-national TB prevalence surveys in India, 2006-2012: Results of uniformly conducted data analysis.

PLoS One 2019 22;14(2):e0212264. Epub 2019 Feb 22.

National Institute for Research in Tuberculosis, Chennai, India.

Setting: Community based tuberculosis (TB) prevalence surveys in ten sites across India during 2006-2012.

Objective: To re-analyze data of recent sub-national surveys using uniform statistical methods and obtain a pooled national level estimate of prevalence of TB.

Methods: Individuals ≥15 years old were screened by interview for symptoms suggestive of Pulmonary TB (PTB) and history of anti-TB treatment; additional screening by chest radiography was undertaken in five sites. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212264PLOS
February 2019

[Retrospective Study of Leprosy in Togo (2000-2014): about 2,630 cases].

Bull Soc Pathol Exot 2018 ;111(2):99-103

Service de dermatologie-vénérologie, CHU de Lomé, faculté des sciences de la santé, université de Lomé, Togo.

The aim of this retrospective study carried out from January 2000 to December 2014 was to determine and map the epidemiological evolutionary trends and the clinical forms of leprosy cases notified in Togo. All the 2,630 new leprosy cases notified by all districts to the National Leprosy/Buruli Ulcer Control Program (PNLLUB-Togo) were included. The mean annual incidence was 175 cases with extremes of 73 to 266 cases. Read More

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http://dx.doi.org/10.3166/bspe-2018-0021DOI Listing
January 2018

A Survey on the Adjuvant Role of Naloxone Alone or Combined with Alum in Vaccination Against Fasciolosis in BALB/c Mice.

Acta Parasitol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Fasciolosis is a zoonotic parasitic disease imposing a heavy load of livestock losses worldwide.

Purpose: We aimed to evaluate immune-stimulatory effects of naloxone (NLX), an opioid receptor antagonist, in combination with alum in mice vaccinated with excretory-secretory antigens (E/S) of Fasciola hepatica.

Methods: 8-week-old female BALB/c mice were subcutaneously vaccinated using E/S antigens of F. Read More

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http://dx.doi.org/10.2478/s11686-019-00030-2DOI Listing
February 2019

A 10-year Retrospective Descriptive Study on Pure Neuritic Leprosy from a Tertiary Referral Centre.

Indian Dermatol Online J 2019 Jan-Feb;10(1):13-18

Health Services Department, Koyilandi Taluk Hospital, Koyilandy, Kerala, India.

Context: Pure neuritic leprosy is a risk factor for grade 2 disability owing to the early nerve damage.

Aims: To study the clinical patterns of neuritic leprosy, to determine the percentage of patients manifesting grade 2 disability at the time of diagnosis and to identify any risk factors for the same.

Settings And Design: Retrospective descriptive study from previous case records of pure neuritic leprosy patients who attended a tertiary centre from 1 July 2007 to 30 June 2017. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_118_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362753PMC
February 2019

HACE1, an E3 ubiquitin-protein ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Infection Induced Oxidative Stress by Promoting Nrf2 Activity.

J Virol 2019 Feb 20. Epub 2019 Feb 20.

Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.

KSHV-induced activation of Nrf2 is essential for both the expression of viral genes (latency) and modulation of the host anti-oxidant machinery. ROS are also regulated by the ubiquitously expressed HACE1 protein (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1) which targets the Rac1 protein for proteasomal degradation, and this blocks the generation of ROS by Rac1-dependent NADPH oxidases. Here, we examined the role of HACE1 in KSHV infection. Read More

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http://dx.doi.org/10.1128/JVI.01812-18DOI Listing
February 2019

Non-communicable diseases and tuberculosis: Anticipating the impending global storm.

Glob Public Health 2019 Feb 20:1-10. Epub 2019 Feb 20.

e Medecins du Monde , Athens , Greece.

The epidemiological transitions that have occurred in low and middle income countries (LMIC) during the past decades have led to an increased prevalence on non-communicable diseases (NCDs) in these countries, where the burden of infectious diseases (IDs), especially tuberculosis (TB), remains high. Although the true dimensions of this comorbidity have not yet been fully understood, there is a growing amount of data, over the last 10 years, that suggest a clear association between NCDs and TB. In particular, there is a continuously increasing body of evidence that diabetes mellitus, chronic respiratory conditions, tobacco use, mental health illnesses and chronic kidney disease increase TB morbidity and mortality and vice versa. Read More

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http://dx.doi.org/10.1080/17441692.2019.1580760DOI Listing
February 2019

Risk factors for physical disability upon release from multidrug therapy in new cases of leprosy at a referral center in Brazil.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e13. Epub 2019 Feb 14.

Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências da Saúde, Infectologia e Medicina Tropical, Belo Horizonte, Minas Gerais, Brazil.

The present study sought to investigate the risk factors for physical disability upon release from multidrug therapy (MDT) in new cases of leprosy, registered at a referral center in Brazil. This is a longitudinal and retrospective study that evaluated 260 patients. Multivariate analyses, using both the ordinal logistic regression, as well as the classification and regression tree (CART) algorithm were performed to determine the factors associated with physical disability upon release from treatment. Read More

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http://dx.doi.org/10.1590/S1678-9946201961013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376927PMC
February 2019

Reading of the Mitsuda test: comparison between diameter and total area by means of a computerized method.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e5. Epub 2019 Feb 14.

Universidade Federal de Minas Gerais, Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Belo Horizonte, Minas Gerais, Brazil.

The Mitsuda test is a skin test based on the individual's immune response through late and highly specific hypersensitivity reaction to the Mycobacterium leprae bacillus. A negative reaction identifies individuals who present a higher risk of becoming ill if exposed to M. leprae and, if they become ill, to develop the virchowian form of disease. Read More

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http://dx.doi.org/10.1590/S1678-9946201961005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376929PMC
February 2019

De novo histoid leprosy in a Colombian patient with multiple skin nodules on the ears and extremities.

Rev Soc Bras Med Trop 2019 Feb 14;52:e20160502. Epub 2019 Feb 14.

School of Medicine, Universidad del Valle, Cali, Colombia.

Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathological, immunological, and bacteriological features. This variant usually occurs in multibacillary patients who have irregular or inadequate treatment. Herein, we report a case of de novo histoid leprosy diagnosed in a patient from Cali, Colombia. Read More

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http://dx.doi.org/10.1590/0037-8682-0502-2016DOI Listing
February 2019

[Persistence of leprosy in household social networks: overlapping cases and vulnerability in endemic regions in Brazil].

Cad Saude Publica 2019 Feb 18;35(2):e00105318. Epub 2019 Feb 18.

Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Brasil.

The study sought to analyze the magnitude of occurrence and the sociodemographic, economic and clinical profiles of leprosy associated with household social networks (HSN), with disease overlap in cities from the states of Bahia, Piauí and Rondônia, Brazil, from 2001 to 2014. This is a cross-sectional study using primary and secondary data regarding new cases of leprosy notified to the Brazilian Information System for Notifiable Diseases (SINAN, in Portuguese) residing in the cities. We applied a standardized instrument to the new cases and reviewed data from charts and from SINAN. Read More

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http://dx.doi.org/10.1590/0102-311X00105318DOI Listing
February 2019

First Report of Alternaria dianthicola Causing Leaf Blight on Withania somnifera from India.

Plant Dis 2007 Apr;91(4):467

Botany Department, Calcutta University, Kolkata, West Bengal, India.

Withania somnifera (L.) Dunal, a potential medicinal plant used for the treatment of nervous disorders, intestinal infection, leprosy, and cancer, is a perennial herb belonging to Solanaceae and distributed throughout the drier parts of India. Leaf blight disease of this plant generally occurs during March in various districts of South Bengal, India. Read More

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http://dx.doi.org/10.1094/PDIS-91-4-0467BDOI Listing

Does histoid leprosy represent a locally hyperimmune variant of lepromatous leprosy?

QJM 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

Background: Histoid leprosy is a subtype of leprosy with distinct clinical presentation and histologic features. It accounts for less than 4 per cent of leprosy cases. The exact location of histoid leprosy along the immune spectrum and its relation to other subtypes is unclear. Read More

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http://dx.doi.org/10.1093/qjmed/hcz043DOI Listing
February 2019

Hepatoprotective and antioxidant effects of Hedera helix extract on acetaminophen induced oxidative stress and hepatotoxicity in mice.

Biotech Histochem 2019 Feb 19:1-7. Epub 2019 Feb 19.

e Center for Research and Training in Skin Diseases and Leprosy , Tehran University of Medical Sciences , Tehran , Iran.

Exposure to high doses of acetaminophen is the most common cause of drug induced liver injury. We investigated the protective effects of Hedera helix extract against acetaminophen induced oxidative stress and hepatotoxicity using a mouse model. We used two control groups: group A was given 0. Read More

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http://dx.doi.org/10.1080/10520295.2019.1566569DOI Listing
February 2019

British Red Squirrels Remain the Only Known Wild Rodent Host for Leprosy Bacilli.

Front Vet Sci 2019 1;6. Epub 2019 Feb 1.

Global Health Institute, Federal Institute of Technology in Lausanne, Lausanne, Switzerland.

Eurasian red squirrels in the British Isles are the most recently discovered animal reservoir for the leprosy bacteria and . Initial data suggest that prevalence of leprosy infection is variable and often low in different squirrel populations. Nothing is known about the presence of leprosy bacilli in other wild squirrel species despite two others (Siberian chipmunk [], and Thirteen-lined ground squirrel []) having been reported to be susceptible to experimental infection with . Read More

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http://dx.doi.org/10.3389/fvets.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367869PMC
February 2019

Diffuse Hair Loss in Females.

Indian Dermatol Online J 2019 Jan-Feb;10(1):73-74

Department of Dermatology, Venereology and Leprosy Lady Hardinge Medical College, New Delhi, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_129_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362745PMC
February 2019

Clinico-Epidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):38-44

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: We studied clinico-epidemiological features of 945 patients with vitiligo with an objective to delineate epidemiological and clinical aspects of vitiligo from this part of the country.

Materials And Methods: The medical records of patients with vitiligo attending outpatient clinic over a 5-year period from January 2013 to December 2017 were analyzed retrospectively for this descriptive, observational study.

Results: There were 449 men and 496 women (m:f 1:1. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_124_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362747PMC
February 2019

The Efficacy and Safety of Intralesional Immunotherapy with Measles, Mumps, Rubella Virus Vaccine for the Treatment of Common Warts in Adults.

Indian Dermatol Online J 2019 Jan-Feb;10(1):19-26

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: Most therapeutic modalities for common warts remain unsatisfactory.

Objectives: To evaluate efficacy and safety of intralesional MMR (measles, mumps, rubella virus) vaccine in the treatment of common warts in adults.

Patients And Methods: There were 110 (M:F = 61:49) patients aged 19-62 years having 1-211 warts over dorsal hands, feet, palms, soles, and periungual skin for 1-252 months. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_142_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362737PMC
February 2019

Correspondence to histoid leprosy: a retrospective clinicopathological study from central Nepal.

Int J Dermatol 2019 Feb 17. Epub 2019 Feb 17.

Scheer Memorial Adventist Hospital, Banepa, Nepal.

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http://dx.doi.org/10.1111/ijd.14396DOI Listing
February 2019
1 Read

A systematic review of multi-level stigma interventions: state of the science and future directions.

BMC Med 2019 Feb 15;17(1):41. Epub 2019 Feb 15.

Department of Health Behavior, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

Background: Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural levels. While existing interventions have produced modest reductions in stigma, their full reach and impact remain limited by a nearly exclusive focus targeting only one level of analysis.

Methods: We conducted the first systematic review of original research on multi-level stigma-reduction interventions. Read More

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http://dx.doi.org/10.1186/s12916-018-1244-yDOI Listing
February 2019

The Health Stigma and Discrimination Framework: a global, crosscutting framework to inform research, intervention development, and policy on health-related stigmas.

BMC Med 2019 Feb 15;17(1):31. Epub 2019 Feb 15.

Yale University, New Haven, CT, USA.

Stigma is a well-documented barrier to health seeking behavior, engagement in care and adherence to treatment across a range of health conditions globally. In order to halt the stigmatization process and mitigate the harmful consequences of health-related stigma (i.e. Read More

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http://dx.doi.org/10.1186/s12916-019-1271-3DOI Listing
February 2019

Out of the silos: identifying cross-cutting features of health-related stigma to advance measurement and intervention.

BMC Med 2019 Feb 15;17(1):13. Epub 2019 Feb 15.

College of Global Public Health, New York University, New York, NY, USA.

Background: Many health conditions perceived to be contagious, dangerous or incurable, or resulting in clearly visible signs, share a common attribute - an association with stigma and discrimination. While the etiology of stigma may differ between conditions and, sometimes, cultural settings, the manifestations and psychosocial consequences of stigma and discrimination are remarkably similar. However, the vast majority of studies measuring stigma or addressing stigma through interventions employ a disease-specific approach. Read More

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https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291
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http://dx.doi.org/10.1186/s12916-018-1245-xDOI Listing
February 2019
3 Reads

Stigma in health facilities: why it matters and how we can change it.

BMC Med 2019 Feb 15;17(1):25. Epub 2019 Feb 15.

Centre for Longitudinal & Life Course Studies, University of Antwerp, Sint-Jacobstraat 2, B-2000, Antwerp, Belgium.

Stigma in health facilities undermines diagnosis, treatment, and successful health outcomes. Addressing stigma is fundamental to delivering quality healthcare and achieving optimal health. This correspondence article seeks to assess how developments over the past 5 years have contributed to the state of programmatic knowledge-both approaches and methods-regarding interventions to reduce stigma in health facilities, and explores the potential to concurrently address multiple health condition stigmas. Read More

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http://dx.doi.org/10.1186/s12916-019-1256-2DOI Listing
February 2019
1 Read

[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax].

Bull Soc Pathol Exot 2018 ;111(1):17-23

Direction d'épidémiologie, de laboratoire et de recherches, 52 angle Delmas 33 et rue Charbonnières, Port-au-Prince, Haïti.

Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungiasis, leprosy and anthrax. Read More

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http://dx.doi.org/10.3166/bspe-2018-0005DOI Listing
January 2018
1 Read

Brain and Spinal Cord Lesions in Leprosy: A Magnetic Resonance Imaging-Based Study.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neurotropism and infiltration by of peripheral nerves causing neuropathy are well established, but reports of central nervous system (CNS) damage are exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities of the brain and spinal cord as well as lesions in nerve roots and plexus in leprosy patients. Eight patients aged between 17 and 41 years underwent detailed clinical, histopathological, and MRI evaluation. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0945DOI Listing
February 2019
3 Reads
2.699 Impact Factor

Prevalence, Predictors, and Successful Treatment Outcomes of Xpert MTB/RIF-identified Rifampicin-resistant Tuberculosis in Post-conflict Eastern Democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study.

Clin Infect Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania.

Background: Multidrug-resistant tuberculosis (MDR-TB) jeopardizes global TB control. The prevalence and predictors of Rifampicin-resistant (RR) TB, a proxy for MDR-TB, and the treatment outcomes with standard and shortened regimens have not been assessed in post-conflict regions, such as the South Kivu province in the eastern Democratic Republic of the Congo (DRC). We aimed to fill this knowledge gap and to inform the DRC National TB Program. Read More

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http://dx.doi.org/10.1093/cid/ciy1105DOI Listing
February 2019

Seronegative Bilateral Symmetrical Inflammatory Polyarthritis: Think Twice Before Starting Immunosuppression.

Eur J Case Rep Intern Med 2018 28;5(8):000895. Epub 2018 Aug 28.

Department of Medicine (Rheumatology), Hamad Medical Corporation, Doha, Qatar.

The most common cause of bilateral symmetrical polyarthritis in the small joints is rheumatoid arthritis. However, if seronegative arthritis is involved, it could be the case that other underlying causes need to be diagnosed. This is particularly important for those coming from or living in developing countries where infectious causes should always be considered. Read More

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http://dx.doi.org/10.12890/2018_000895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346836PMC
August 2018
1 Read

Giant and Extensive Localized Xanthoma Associated with Primary Lymphedema.

Indian J Dermatol 2019 Jan-Feb;64(1):65-67

Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Lymphedema is extravasation of lymphatic fluid into extracellular spaces and may be primary or secondary. Primary lymphedema may be caused by truncular lymphatic malformation. Long-standing lymphedema may result in various complications due to increased porosity of lymphatics, defective valves, and increased lymphatic pressure. Read More

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http://dx.doi.org/10.4103/ijd.IJD_150_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340231PMC
February 2019
1 Read

Linear Lichen Nitidus with Onychodystrophy in a Child.

Indian J Dermatol 2019 Jan-Feb;64(1):62-64

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Lichen nitidus is a common dermatosis described classically as shiny, skin-colored, nonfollicular, flat-topped papules. A number of variants have been described in literature including localized, generalized, actinic, vesicular, perforating, hemorrhagic, palmar/plantar, purpuric, and linear forms. Here, we report an unusual case of linear lichen nitidus in an 11-year-old boy mimicking lichen striatus along the left thumb with isolated nail involvement of the affected digit. Read More

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http://dx.doi.org/10.4103/ijd.IJD_754_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340236PMC
February 2019
1 Read

Generalized Livedo Reticularis: A Rare Variety.

Indian J Dermatol 2019 Jan-Feb;64(1):59-61

Department of Dermatology, Venereology and Leprosy, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

Livedo reticularis can present with progressive ischemia and diffuse cutaneous involvement with or without any evidence of systemic diseases. Livedo reticularis (LR) is a livedoid discoloration of the skin in a reticular pattern. We report the case of a 30-year-old male who presented with an asymptomatic, red-colored, net-like rash all over the body for 4 years. Read More

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http://dx.doi.org/10.4103/ijd.IJD_246_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340240PMC
February 2019
1 Read

The Association of Metabolic Syndrome and Insulin Resistance in Early-Onset Androgenetic Alopecia in Males: A Case-Control Study.

Indian J Dermatol 2019 Jan-Feb;64(1):23-27

Department of Dermatology, Venereology and Leprosy, Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka, India.

Background: Men with premature androgenetic alopecia (AGA) are found to be susceptible to cardiovascular diseases, metabolic syndrome (MS), diabetes mellitus and hypertension, and also premature baldness can have a definite negative impact on self-image and self-esteem in these patients. The aim of this study was to assess the strength of association between MS and/or insulin resistance (IR) in males with early-onset AGA.

Methods: A total of 50 male patients with premature AGA and equal number of age-matched controls were enrolled in the study. Read More

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http://dx.doi.org/10.4103/ijd.IJD_724_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340235PMC
February 2019
2 Reads

Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study.

Lancet Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; Centre for Infectious Disease Epidemiology & Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

Background: Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory.

Methods: This multicentre cohort study was done in Côte d'Ivoire, Democratic Republic of the Congo, Kenya, Nigeria, South Africa, Peru, and Thailand. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30673-XDOI Listing
February 2019
1 Read

Spatial and temporal projections of the prevalence of active tuberculosis in Cambodia.

BMJ Glob Health 2019 24;4(1):e001083. Epub 2019 Jan 24.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.

Introduction: Cambodia is among the 30 highest burden of tuberculosis (TB) countries. Active TB prevalence has been estimated using nationally representative multistage sampling that represents urban, rural and remote parts of the country, but the prevalence in non-sampled communes remains unknown. This study uses geospatial Bayesian statistics to estimate point prevalence across Cambodia, and demographic modelling that accounts for secular trends in fertility, mortality, urbanisation and prevalence rates to project the future burden of active TB. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347953PMC
January 2019
1 Read

Plantar ulcer occurrence among leprosy patients in Northern Nigeria: A study of contributing factors.

Ann Afr Med 2019 Jan-Mar;18(1):7-11

Netherlands Leprosy Relief, Tador House Rayfield Jos, Nigeira.

Background: The study was conducted in three major leprosy referral hospitals in Northern Nigeria, which are NKST Rehabilitation Hospital, Benue State, Yadakunya Leprosy Hospital, Kano, and National Tuberculosis/Leprosy Training Hospital, Zaria. The main objective of the study was to investigate factors responsible for the occurrence of ulcers among leprosy patients reporting to the leprosy referral hospitals.

Materials And Methods: An analytic study of case-control design was used, with patients having plantar ulcers as cases and those without as control. Read More

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http://dx.doi.org/10.4103/aam.aam_162_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380119PMC
February 2019

[The refinement of leprosy PCR diagnostics by the amplification of specie-specific repeated fragment of the Mycobacterium leprae genome.]

Klin Lab Diagn 2018 ;63(8):511-516

FGBU "State Scientific Center of Dermatovenereology and Cosmetology" Ministry of Health of Russia, 107076, Moscow, Russia.

Certain level of new registered cases of leprosy in a number of endemic countries in the world, as well as growing rate of transboundary migratory flows, raise the issue of effective diagnosis of this disease in countries with sporadic incidence of leprosy, including the Russian Federation. The purpose of the study was to develop a highly sensitive PCR test for detecting the genetic material of Mycobacterium leprae and to compare the test robustness and sensitivity with the commercially available Leprosy Genesig Standard Kit (Primerdesign Ltd., UK). Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-8-511-516DOI Listing
January 2018

Erythroderma as a manifestation of leprosy.

An Bras Dermatol 2019 Jan-Feb;94(1):89-92

Department of Dermatology, Hospital Universitário Evangélico de Curitiba, Faculdade Evangélica do Paraná, Curitiba (PR), Brazil.

Erythroderma consists of erythema and scaling involving most or all of the body surface. This generalized eruption may be idiopathic, drug-induced or secondary to cutaneous or systemic disease. A 71-year-old man is reported presenting generalized erythema and desquamation with deck-chair sign, nail dystrophy, and plantar ulcers associated with loss of local tactile sensitivity. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360983PMC
November 2017
2 Reads

Spatial approach of leprosy in the State of São Paulo, 2009-2012.

An Bras Dermatol 2019 Jan-Feb;94(1):37-41

Envirommental Science Post-Graduation Program, Universidade de Taubaté, Taubaté (SP), Brazil.

Background: Leprosy is a chronic, infectious disease that affects the skin and the peripheral nervous system and can lead to permanent disability and/or deformity.

Objectives: To identify the distribution and to quantify the spatial dependence of the detection rates of new cases of Hansen's disease in the State of São Paulo, correlating with socioeconomic variables.

Methods: Ecological and exploratory study with data on the detection rates of new cases of Hansen's disease among residents of São Paulo State municipalities between 2009-2012. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360960PMC
June 2017
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Hansen's disease deformities in a high risk area in Mozambique: A case study.

Rev Soc Bras Med Trop 2019 Jan 31;52:e20180103. Epub 2019 Jan 31.

Nampula Provincial Health Directorate, Ministry of Health, Nampula, Mozambique.

Introduction: Hansen's disease is no longer a public health problem in Mozambique, since 2008 (incidence under 1 / 10,000 inhabitants). The country is one of the most affected in the world and Nampula province's Murrupula district (incidence 1.7 / 10,000) has a high deformity rate (22% in 2010). Read More

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http://dx.doi.org/10.1590/0037-8682-0103-2018DOI Listing
January 2019
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"If you will counsel properly with love, they will listen": A qualitative analysis of leprosy affected patients' educational needs and caregiver perceptions in Nepal.

PLoS One 2019 6;14(2):e0210955. Epub 2019 Feb 6.

Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Background: Leprosy remains a disease of concern in many countries including Nepal. To achieve the target of elimination, the WHO strategy promotes comprehensive education of patients, healthcare workers (HCWs), and the public on leprosy-related issues. However most educational programs are based on the concerns of HCWs and not on patients' needs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210955PLOS
February 2019

Abandoning the stigma of leprosy.

Authors:
The Lancet

Lancet 2019 02;393(10170):378

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http://dx.doi.org/10.1016/S0140-6736(19)30164-3DOI Listing
February 2019

Chronic aspects of leprosy-neglected but important.

Trans R Soc Trop Med Hyg 2019 Jan 31. Epub 2019 Jan 31.

Professor of Tropical Medicine, London School of Hygiene and Tropical Medicine, Keppel St London, UK.

The chronic aspects of leprosy are discussed here. They are a consequence of the peripheral nerve damage that affects many patients during their lifetime with leprosy. The peripheral nerve damage leaves people unable to feel and with weakness in their hands and feet. Read More

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http://dx.doi.org/10.1093/trstmh/try131DOI Listing
January 2019
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When amplified direct (MTD) testing confuses leprosy diagnosis: A case report.

JAAD Case Rep 2019 Feb 17;5(2):131-133. Epub 2019 Jan 17.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, New York.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348301PMC
February 2019
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The mystery of 'saturation gap': a case of dapsone-induced methaemoglobinemia in a pregnant mother with leprosy.

Oxf Med Case Reports 2019 Jan 24;2019(1):omy111. Epub 2019 Jan 24.

Dermatology Unit, Department of Internal Medicine, Sarawak General Hospital, Sarawak, Malaysia.

Limited data regarding methemoglobinemia in pregnancy, particularly secondary to dapsone is available up to date. We report a case of dapsone-induced methemoglobinemia in a pregnant mother with multibacillary leprosy who presented with fever, productive cough and cyanosis of 2 days duration 2 weeks after multidrug therapy was commenced. On examination, she had central cyanosis with low oxygen saturation (SpO = 84-88%). Read More

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http://dx.doi.org/10.1093/omcr/omy111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345088PMC
January 2019
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Fingerstick test quantifying humoral and cellular biomarkers indicative for M. leprae infection.

Clin Biochem 2019 Jan 26. Epub 2019 Jan 26.

Dept. of Infectious Diseases, Leiden University Medical Center, The Netherlands. Electronic address:

Objectives: New user-friendly diagnostic tests for detection of individuals infected by Mycobacterium leprae (M. leprae), the causative pathogen of leprosy, can help guide therapeutic and prophylactic treatment, thus positively contributing to clinical outcome and reduction of transmission. To facilitate point-of-care testing without the presence of phlebotomists, the use of fingerstick blood (FSB) rather than whole blood-derived serum is preferred. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00099120183076
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http://dx.doi.org/10.1016/j.clinbiochem.2019.01.007DOI Listing
January 2019
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Bathing Suit Variant of Autosomal Recessive Congenital Ichthyosis (ARCI) in Two Indian Patients.

Case Rep Dermatol Med 2018 30;2018:3140473. Epub 2018 Dec 30.

Department of Dermatology, University Hospital Muenster, Muenster, Germany.

Bathing suit ichthyosis (BSI) is a rare variant of autosomal recessive congenital ichthyosis (ARCI) due to transglutaminase-1 gene () mutations leading to a temperature sensitive phenotype. It is characterized by dark-grey or brownish scaling restricted to the "bathing suit" areas. We report two Indian girls with bathing suit ichthyosis and mutations in (patient 1: homozygous for c. Read More

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http://dx.doi.org/10.1155/2018/3140473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332984PMC
December 2018
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Picturing health: a new face for leprosy.

Lancet 2019 Feb 25;393(10172):629-638. Epub 2019 Jan 25.

London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736193015
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http://dx.doi.org/10.1016/S0140-6736(19)30158-8DOI Listing
February 2019
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Assessing the Impact of the Twin Track Socio-Economic Intervention on Reducing Leprosy-Related Stigma in Cirebon District, Indonesia.

Int J Environ Res Public Health 2019 Jan 26;16(3). Epub 2019 Jan 26.

Athena Institute, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

The consequences of leprosy go beyond the physical, social and psychological, as leprosy can drive persons affected and their families into poverty, stigmatization and disability. This paper describes the impact of a socio-economic development (SED) intervention that uses a twin-track approach (two micro-credit models) to reduce leprosy-related stigma in Cirebon District, Indonesia. A randomized-controlled mixed-methods study design was used to test the effectiveness of the SED intervention. Read More

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http://dx.doi.org/10.3390/ijerph16030349DOI Listing
January 2019
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Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum.

PLoS Negl Trop Dis 2019 01 28;13(1):e0007089. Epub 2019 Jan 28.

Department of Biochemistry, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Background: Leprosy is a treatable infectious disease caused by Mycobacterium leprae. However, there is additional morbidity from leprosy-associated pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL), which occur in 1 in 3 people with leprosy, even with effective treatment of M. leprae. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007089DOI Listing
January 2019
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Unusual association of leprosy with Lucio phenomenon with secondary antiphospholipid antibody syndrome and ischemic stroke.

Neurol India 2019 Jan-Feb;67(Supplement):S150-S151

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/0028-3886.250724DOI Listing
January 2019
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Macular hypopigmentation, hair loss and follicular spongiosis: A distinct clinicopathological entity.

Indian J Dermatol Venereol Leprol 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Hypopigmented macules are seen in a variety of disorders and the diagnosis rests on clinicopathological correlation. However, some cases are difficult to classify and pose a diagnostic challenge.

Aim: To describe the clinical and histopathological features of patients with hypopigmented macules and follicular spongiosis on histopathology. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_679_17DOI Listing
January 2019
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