1,275 results match your criteria Lentigo Maligna Melanoma


[Ancillary values of fluorescence in situ hybridization with different gene combination in diagnosis of malignant melanoma].

Zhonghua Bing Li Xue Za Zhi 2020 Aug;49(8):827-833

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the clinical value of the first multicolor fluorescence in situ hybridization (FISH) assay on multiple genes, and combined with 9p21 and 8q24 evaluation in the differential diagnosis of melanoma. Fifty-six melanomas and 36 benign melanocytic nevi diagnosed in Fudan University Shanghai Cancer Center from 2017 to 2019 were included. Each specimen was examined by first multicolor FISH assay targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1) and CEP6, as well as 9p21 (CDKN2A) and 8q24 (MYC). Read More

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http://dx.doi.org/10.3760/cma.j.issn.cn112151-20200601-00435DOI Listing

In vivo and ex vivo confocal microscopy for the evaluation of surgical margins of melanoma.

J Biophotonics 2020 Jul 24:e202000179. Epub 2020 Jul 24.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

Background: We report the first series of melanomas (MMs) where the surgical margins were evaluated both by ex vivo (EVCM) and in vivo (RCM) reflectance confocal microscopy.

Methods: We evaluated the surgical margins of 42 cutaneous MMs of lentigo maligna (LM)/lentigo maligna melanoma (LMM) type and 2 mucosal MMs with EVCM. Cutaneous MMs also underwent RCM mapping. Read More

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http://dx.doi.org/10.1002/jbio.202000179DOI Listing

Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma.

Am J Dermatopathol 2020 Aug;42(8):625-627

Department of Dermatology, Netherlands Institute for Pigment Disorders, Amsterdam UMC, Amsterdam Infection & Immunity Institute, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

The cancer/testis antigens (CTA) are a group of antigens expressed on germ cells of healthy testis and malignant tumors. We studied whether CTA are present on lentigo maligna (LM) and LM melanoma (LMM) samples. Immunohistochemical expression of a panel of CTA (MAGE-A1, A2- A3, NY-ESO-1, PRAME, SSX-2, and a MAGE-A antibody reactive with -A1, -A2, -A3, -A4, -A6, -A10, and -A12) was investigated in formalin-fixed paraffin-embedded samples from LMM (n = 20), LM (n = 8), chronically sun-exposed skin (n = 7), and healthy skin (n = 7). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001607DOI Listing

[Rotation advancement flap with subcutaneous pedicle in the jugal region following excision of lentigo maligna melanoma].

Ann Dermatol Venereol 2020 Jul 14. Epub 2020 Jul 14.

Service de dermatologie, unité de dermatologie interventionnelle, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.annder.2020.06.008DOI Listing

Radiotherapy for lentigo maligna and lentigo maligna melanoma - a systematic review.

Radiat Oncol 2020 Jul 14;15(1):174. Epub 2020 Jul 14.

Department of Radiation Oncology, Kantonsspital St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland.

Lentigo maligna (LM) is the most common subtype of in situ melanoma und occurs frequently in the sun-exposed head and neck region in elderly patients. The therapeutic "gold standard" is surgical excision, as there is the risk of progression to invasive (lentigo maligna) melanoma (LMM). However, surgery is not feasible in certain patients due to age, comorbidities or patient preference. Read More

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http://dx.doi.org/10.1186/s13014-020-01615-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362499PMC

Desmoplastic Melanoma as a Diagnostic Pitfall.

Acta Dermatovenerol Croat 2020 Jul;28(1):49-50

Dear Editor, Desmoplastic melanoma (DM) is a rare histological subtype of melanoma, usually presenting as a slowly-growing, amelanotic, discoid, and/or firm lesion composed of spindle cells with abundant collagen (1). It is more common on sun-exposed areas, especially on head and neck in elderly patients (2). Regional lymph node involvement is reported to be less frequent than in other cutaneous melanomas (3). Read More

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Topical Imiquimod for Management of Recurrent Lentigo Maligna Melanoma in Situ.

Acta Dermatovenerol Croat 2020 Jul;28(1):34-37

Professor Igor Bartenjev, MD, PhD, Department of Dermatovenerology, Medical faculty, University of Ljubljana, Pod kostanji 4, 1000 Ljubljana, Slovenia;

Topical imiquimod is a medication approved for the treatment of external genital and perianal warts, actinic keratosis, and superficial basal cell carcinoma. There have also been reports of its successful use in patients with lentigo maligna melanoma in situ. An 80-year-old female patient was diagnosed with lentigo maligna melanoma in situ which was then surgically removed. Read More

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Amelanotic melanoma in a patient with oculocutaneous albinism.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Hospital Clinico Universitario de Valladolid, Valladolid.

Oculocutaneous albinism is a genetically heterogeneous, autosomal recessive group of disorders characterized by a generalized decreased or absence of melanin pigment in the eyes, hair, and skin. These patients have a greater sensitivity to UV radiation and a predisposition to skin tumors, mainly squamous cell carcinoma and basal cell carcinomas, and to a lesser extent malignant melanomas. Melanoma can be one of the most challenging cancers to diagnose in patients with albinism. Read More

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The dermatoscopic inverse approach significantly improves the accuracy of human readers for lentigo maligna diagnosis.

J Am Acad Dermatol 2020 Jun 24. Epub 2020 Jun 24.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: A recently introduced dermatoscopic method for diagnosis of early lentigo maligna (LM) is based on the absence of prevalent patterns of pigmented actinic keratosis (PAK) and solar lentigo/flat seborrheic keratosis (SL/SK). We term this the "inverse approach" OBJECTIVE: To determine whether training on the inverse approach increases the diagnostic accuracy of readers as compared to classic pattern analysis.

Methods: We used clinical and dermatoscopic images of histopathologically diagnosed LMs, PAKs and SLs/SKs. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.085DOI Listing

Lentigo maligna melanoma in situ with neurotropism.

J Cutan Pathol 2020 Jun 18. Epub 2020 Jun 18.

Department of Pathology, New York University Langone Health, New York, New York, USA.

Perineural invasion, or neurotropism, is defined by the presence of cancer cells either within the neuronal sheath or found along the nerves. In melanoma, it is most commonly associated with invasive desmoplastic melanoma, a melanoma that is most commonly associated with malignant melanoma in situ, lentigo maligna type. Initially, perineural invasion was included in the reported Breslow thickness; however, recent data suggest that it should not be included. Read More

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http://dx.doi.org/10.1111/cup.13778DOI Listing

Cutaneous Head and Neck Melanoma: Changes in Clinical and Histologic Features From 1995 to 2015 in a Tertiary Hospital in Madrid, Spain.

Actas Dermosifiliogr 2020 Jun 12. Epub 2020 Jun 12.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Objectives: Few epidemiological studies have analyzed cutaneous head and neck melanoma (CHNM) in the Spanish population. The aim of this study was to describe the clinical and histologic features of a representative sample of CHNM in Spain and to analyze changes observed over a period of 21 years.

Material And Methods: Descriptive, retrospective, cross-sectional study of 280 patients diagnosed with CHNM at Hospital General Universitario Gregorio Marañón in Madrid, Spain, between January 1, 1995, and December 31, 2015. Read More

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http://dx.doi.org/10.1016/j.ad.2019.12.002DOI Listing

Holistic Patient Assessment: Dermatology in Dental Practice.

Prim Dent J 2020 Mar;9(1):37-42

Consultant Oral and Maxillofacial Surgeon, King's College Hospital, Reader in Oral and Maxillofacial Surgery, King's College London.

As part of the holistic approach to their patients, General Dental Practitioners are well placed to identify common skin lesions. Awareness and recognition of worrying lesions allow timely and appropriate referrals for further investigation and treatment. In this paper, we review benign, premalignant and malignant skin lesions, as well as genetic skin conditions. Read More

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http://dx.doi.org/10.1177/2050168420911028DOI Listing

Junctional Melanocytic Hyperplasia Overlying Benign Fibrous Papule: An Under-recognized Variant of a Common Lesion.

J Cutan Pathol 2020 Jun 4. Epub 2020 Jun 4.

Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Fibrous papule (angiofibroma) is a common benign tumor often presenting as an erythematous papule on the face of an adult, most commonly on the nose. The clinical differential diagnosis is often fibrous papule, basal cell carcinoma, or intradermal nevus. A number of histologic variants of fibrous papule are described, including a variant with junctional melanocytic hyperplasia that can resemble lentigo maligna. Read More

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http://dx.doi.org/10.1111/cup.13767DOI Listing

Epidemiology of Melanoma in the Czech Republic in East Bohemia in the Period 2002-2017 and the Effect of the Annual Sunshine Exposure.

Acta Medica (Hradec Kralove) 2020 ;63(1):10-17

Department of Dermatology and Venereology Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Aim: The evaluation of the trend in the occurrence of melanoma nodulare, melanoma superficiale, lentigo maligna and melanoma in situ in the period of 2002-2017 in East Bohemia region in the Czech Republic. We examine if the annual numbers of hours of sunshine could affect the number of patients with melanoma.

Method: In the peridod of 2002-2017, altogether 2230 patients with new diagnosis of melanoma were examined. Read More

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http://dx.doi.org/10.14712/18059694.2020.10DOI Listing
January 2020

Superficial dermal melanocytosis of the elderly: An exceptional occurrence?

J Cutan Pathol 2020 May 10. Epub 2020 May 10.

Dermatopathology Bodensee, Friedrichshafen, Germany.

The development of flat pigmented lesions on chronically sun-damaged (CSD) skin of the face may represent the clinical manifestation of a wide variety of hyperplastic/neoplastic melanocytic proliferations. We report the exceptional case of an acquired pigmented patch occurring on CSD skin, histopathologically characterized by diffuse hyperplasia of dendritic/spindled melanocytes in the superficial dermis within a widened band of actinic elastosis. This lesion was associated with a small focus of early invasive lentigo maligna melanoma (LMM). Read More

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http://dx.doi.org/10.1111/cup.13737DOI Listing

Lentigo maligna in a patient with xeroderma pigmentosum, variant type: A case report with dermoscopic findings and review of the literature.

Photodermatol Photoimmunol Photomed 2020 May 7. Epub 2020 May 7.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/phpp.12568DOI Listing

SOX-10 and S100 Negative Desmoplastic Melanoma: Apropos a Diagnostically Challenging Case.

Am J Dermatopathol 2020 Feb 25. Epub 2020 Feb 25.

Dermatology Section, Department of Medicine, VA Boston Healthcare System, Boston, MA.

An 83-year-old man presented with a tumor of the neck, clinically consistent with an epidermal inclusion cyst. Excisional biopsy revealed a deeply infiltrating spindled cell tumor. Immunohistochemical markers for S100, SOX-10, Melan-A, HMB-45, and NK1/C3 were negative. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001626DOI Listing
February 2020

Lentigo maligna and intensified ablative fractional laser-assisted PDT: a promising, minimally invasive treatment approach.

Authors:
L Marini S Marini

J Eur Acad Dermatol Venereol 2020 03;34(3):440-441

Queen's University School of Medicine, Belfast, UK.

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http://dx.doi.org/10.1111/jdv.16262DOI Listing

The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.

Arch Pathol Lab Med 2020 04 14;144(4):500-522. Epub 2020 Feb 14.

From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Dr Elder); the Department of Dermatology, University of California San Francisco, San Francisco (Dr Bastian); International Agency for Research on Cancer, Lyon, France (Dr Cree); Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy (Dr Massi); and the Department of Pathology and Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Scolyer).

Context.—: There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0561-RADOI Listing

Incompletely excised lentigo maligna melanoma is associated with unpredictable residual disease: clinical features and the emerging role of reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2020 Feb 7. Epub 2020 Feb 7.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Lentigo maligna/lentigo maligna melanoma (LM/LMM) poses a treatment and surgical challenge given unpredictable subclinical extension resulting in incomplete excision.

Objectives: To describe the demographic, clinical and pathologic characteristics of incompletely excised LM/LMM. To evaluate the potential role of reflectance confocal microscopy (RCM). Read More

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http://dx.doi.org/10.1111/jdv.16272DOI Listing
February 2020

Progressive Disease in Sentinel-negative Melanoma Patients: Biological Differences and Importance of Sentinel Lymph Node Biopsy.

Anticancer Res 2020 Feb;40(2):891-899

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland

Background/aim: Among the most important prognostic factors in melanoma is the sentinel lymph node (SLN) status.

Materials And Methods: Using our electronic database we identified 109 of 890 SLN-negative patients with progressive disease (PD). These patients were characterized for melanoma type, molecular type, sequence and extent of metastatic spread. Read More

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http://dx.doi.org/10.21873/anticanres.14022DOI Listing
February 2020

Upstaging of melanoma in situ and lentigo maligna treated with Mohs micrographic surgery rarely results in additional surgical management.

Arch Dermatol Res 2020 Jan 30. Epub 2020 Jan 30.

Department of Dermatology, Brigham and Women's Hospital, Mohs and Dermatologic Surgery Center, Harvard Medical School, 1153 Centre Street, Suite 4J, Boston, MA, 02130, USA.

As Mohs micrographic surgery (MMS) is more widely utilized for melanoma in situ (MIS) and lentigo maligna (LM), there is increasing concern over whether the procedure can negatively affect the treatment of upstaged tumors. Previous studies have shown that about 1-2% of MIS/LM treated with MMS require sentinel lymph node biopsy, but little is still known regarding surgical outcomes. We performed a retrospective chart review of 117 MIS/LM lesions treated with MMS at Brigham and Women's Hospital. Read More

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http://dx.doi.org/10.1007/s00403-020-02034-9DOI Listing
January 2020

Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma.

Am J Dermatopathol 2020 Jan 14. Epub 2020 Jan 14.

Department of Dermatology, Netherlands Institute for Pigment Disorders, Amsterdam UMC, Amsterdam Infection & Immunity Institute, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

The cancer/testis antigens (CTA) are a group of antigens expressed on germ cells of healthy testis and malignant tumors. We studied whether CTA are present on lentigo maligna (LM) and LM melanoma (LMM) samples. Immunohistochemical expression of a panel of CTA (MAGE-A1, A2- A3, NY-ESO-1, PRAME, SSX-2, and a MAGE-A antibody reactive with -A1, -A2, -A3, -A4, -A6, -A10, and -A12) was investigated in formalin-fixed paraffin-embedded samples from LMM (n = 20), LM (n = 8), chronically sun-exposed skin (n = 7), and healthy skin (n = 7). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001607DOI Listing
January 2020

Melanoma recognition by a deep learning convolutional neural network-Performance in different melanoma subtypes and localisations.

Eur J Cancer 2020 03 20;127:21-29. Epub 2020 Jan 20.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Deep learning convolutional neural networks (CNNs) show great potential for melanoma diagnosis. Melanoma thickness at diagnosis among others depends on melanoma localisation and subtype (e.g. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.11.020DOI Listing

Commentary on: Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars.

J Eur Acad Dermatol Venereol 2020 01;34(1):13

Service de Dermatologie, Hôpital Universitaire de Saint-Etienne, St. Etienne, France.

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http://dx.doi.org/10.1111/jdv.16046DOI Listing
January 2020

Defining Surgical Margins With Wood Lamp.

Dermatol Pract Concept 2020 31;10(1):e2020018. Epub 2019 Dec 31.

Department of Dermatology, University Hospital of Wales, Cardiff, UK.

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http://dx.doi.org/10.5826/dpc.1001a18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936641PMC
December 2019

The anatomic distribution of cutaneous melanoma: A detailed study of 5141 lesions.

Australas J Dermatol 2020 May 27;61(2):125-133. Epub 2019 Dec 27.

Victorian Melanoma Service, Alfred Health, Melbourne, Victoria, Australia.

Background/objectives: There is evidence that cutaneous melanomas at different anatomic sites present with distinctive clinicopathologic features. We examined the anatomic distribution of cutaneous melanoma and its variation by patient characteristics, subtype and Breslow thickness, using high-resolution anatomic site data.

Methods: A cross-sectional study was performed of all primary cutaneous melanoma cases managed at a tertiary referral centre, analysing prospectively collected clinical data across 50 anatomic subsites. Read More

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http://dx.doi.org/10.1111/ajd.13223DOI Listing

Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study.

J Am Acad Dermatol 2019 Dec 5. Epub 2019 Dec 5.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Lentigo maligna/lentigo maligna melanoma (LM/LMM) can present with subclinical extension that may be difficult to define preoperatively and lead to incomplete excision and potential recurrence. Preliminarily studies have used reflectance confocal microscopy (RCM) to assess LM/LMM margins.

Objective: To evaluate the correlation of LM/LMM subclinical extension defined by RCM compared to the gold standard histopathology. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.11.058DOI Listing
December 2019

[Diagnostics and treatment of lentigo maligna melanoma in Denmark].

Ugeskr Laeger 2019 Oct;181(44)

The incidence of maligna melanoma has doubled in Denmark over the latest 30 years. Lentigo maligna melanomas (LMM) account for 10-26% of the melanomas in head and neck. LMM most often strike people over the age of 70 years and frequently occur in sun-exposed skin areas. Read More

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October 2019

Repigmentation of gray hairs with lentigo maligna and response to topical imiquimod.

JAAD Case Rep 2019 Dec 13;5(12):1015-1017. Epub 2019 Nov 13.

Cutaneous Oncology Division, Scully-Welsh Cancer Center, Cleveland Clinic Indian River Hospital, Vero Beach, Florida.

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http://dx.doi.org/10.1016/j.jdcr.2019.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864298PMC
December 2019

Neck Melanoma: Clinical, Dermoscopic and Confocal Features.

Dermatology 2020 8;236(3):241-247. Epub 2019 Nov 8.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: The head and neck are considered one single anatomical unit. No data on clinical, dermoscopic and confocal aspects of neck melanoma are currently available.

Objectives: To identify clinical, dermoscopic and confocal diagnostic features of neck melanomas. Read More

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http://dx.doi.org/10.1159/000503284DOI Listing
November 2019

Topical treatments for skin cancer.

Adv Drug Deliv Rev 2019 Nov 6. Epub 2019 Nov 6.

Cancer Drug Mechanisms Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; School of Biomedical Sciences Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address:

Skin cancer is a broad term used to describe a number of different malignant indications of the skin. Skin cancers mostly comprise of the keratinocyte cancers [Basal Cell Carcinoma (BCC) and cutaneous Squamous Cell Carcinoma (SCC)], and melanoma. Surgical excision of these malignancies has been the preferred treatment of patients for decades. Read More

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http://dx.doi.org/10.1016/j.addr.2019.11.002DOI Listing
November 2019

Mohs surgery for the treatment of lentigo maligna and lentigo maligna melanoma - a systematic review.

J Dermatolog Treat 2019 Nov 20:1-7. Epub 2019 Nov 20.

Department of Dermatology, University of California, Irvine, CA, USA.

The role of Mohs micrographic surgery (MMS) in the treatment of lentigo maligna (LM), and lentigo maligna melanoma (LMM) has been controversial. The use of frozen sections is commonly cited as a suboptimal way to distinguish atypical melanocytes, resulting in traditional wide-local excision techniques as the mainstay of therapy. To compare the success of MMS as a treatment option for LM and LMM with that of traditional surgical and nonsurgical therapies by analyzing the published recurrence rates of these lesions after MMS procedures. Read More

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http://dx.doi.org/10.1080/09546634.2019.1690624DOI Listing
November 2019
1.764 Impact Factor

Evidence-Based Clinical Practice Guidelines for the Management of Patients with Lentigo Maligna.

Dermatology 2020 22;236(2):111-116. Epub 2019 Oct 22.

Dermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia,

Introduction: Lentigo maligna (LM) is a subtype of melanoma in situ that usually occurs in sun-damaged skin and is characterised by an atypical proliferation of melanocytes within the basal epidermis. If left untreated, LM can develop into invasive melanoma, termed lentigo maligna melanoma, which shares the same prognosis as other types of invasive melanoma. The incidence rates of LM are steadily increasing worldwide, in parallel with increases in the incidence rates of invasive melanoma, and establishing appropriate guidelines for the management of LM is therefore of great importance. Read More

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http://dx.doi.org/10.1159/000502470DOI Listing
October 2019

Factors associated with sentinel lymph node status and prognostic role of completion lymph node dissection for thick melanoma.

Eur J Surg Oncol 2020 02 2;46(2):263-271. Epub 2019 Oct 2.

Dermatology Department, Instituto Valenciano de Oncología, Valencia, Spain.

Introduction: Sentinel lymph node (SLN) biopsy is useful for the prognostic stratification of patients with thick melanoma. Identifying which variables are associated with SLN involvement and establishing risk in different subgroups of patients could be useful for guiding the indication of SLN biopsy. The value of complete lymph node dissection (CLND) in patients with a positive SLN biopsy is currently under debate. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.09.189DOI Listing
February 2020
1 Read
3.009 Impact Factor

A Distinct Pretreatment Immune Gene Signature in Lentigo Maligna Is Associated with Imiquimod Response.

J Invest Dermatol 2020 Apr 30;140(4):869-877.e16. Epub 2019 Sep 30.

Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Lentigo maligna (LM) is a common subtype of in situ melanoma on chronically sun-exposed skin, particularly the head and neck of older patients. Although surgery is the standard treatment, there is associated morbidity, and options such as imiquimod cream or radiotherapy may be used if surgery is refused or inappropriate. Complete response rates following imiquimod treatment are variable in the literature. Read More

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http://dx.doi.org/10.1016/j.jid.2019.07.725DOI Listing
April 2020
4 Reads

Dermoscopic Differentiation of Facial Lentigo Maligna from Pigmented Actinic Keratosis and Solar Lentigines.

Acta Dermatovenerol Croat 2019 Sep;27(3):146-152

Ozlem Ozbagcivan, MD, Dokuz Eylul University, Faculty of Medicine, Department of Dermatology, 35340 Inciralti, Izmir, Turkey;

The differential diagnosis of lentigo maligna (LM) from pigmented actinic keratosis (PAK) and solar lentigines (SL) remains a challenge for clinicians, especially in the early stages of LM when there are no distinctive dermoscopic features. Objective of this study was to evaluate the frequencies of selective dermoscopic criteria in LM, PAK, and SL and to find the specific combination of distinguishing dermoscopic criteria for LM. Dermoscopists blinded to histopathological diagnosis evaluated 42 LM, 107 PAK, and 16 SL for the presence of predefined dermoscopic criteria. Read More

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September 2019
5 Reads

Response to 'Long-term outcomes of imiquimod-treated lentigo maligna'.

Clin Exp Dermatol 2020 03 19;45(2):274. Epub 2019 Sep 19.

Department of Dermatology, NHS Treatment Centre, Nottingham, UK.

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http://dx.doi.org/10.1111/ced.14090DOI Listing

Ablative fractional laser-assisted photodynamic therapy for lentigo maligna: a prospective pilot study.

J Eur Acad Dermatol Venereol 2020 Mar 10;34(3):510-517. Epub 2019 Oct 10.

Department of Dermatology, Päijät-Häme Social and Health Care Group, Lahti, Finland.

Background: Lentigo maligna (LM) is an in situ form of melanoma carrying a risk of progression to invasive lentigo maligna melanoma (LMM). LM poses a clinical challenge, with subclinical extension and high recurrence rates after incomplete surgery. Alternative treatment methods have been investigated with varying results. Read More

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http://dx.doi.org/10.1111/jdv.15925DOI Listing
March 2020
2 Reads

Long-term outcomes of imiquimod-treated lentigo maligna: add on cryosurgery to induce inflammation and increase efficacy?

Clin Exp Dermatol 2020 03 5;45(2):272. Epub 2019 Sep 5.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

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http://dx.doi.org/10.1111/ced.14065DOI Listing

Clinical usefulness of dermoscopy in the management of lentigo maligna melanoma treated with topical imiquimod: A case report.

Dermatol Ther 2019 09 12;32(5):e13048. Epub 2019 Aug 12.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

The importance of dermoscopy for diagnosing lentigo maligna melanoma (LMM) is well known. More recently, dermoscopy has been proposed as a useful tool also for the treatment choice and monitoring. Herein, we present an 87-year-old woman, who was successfully treated with imiquimod 5% cream after surgical persistence of residual LMM and for whom dermoscopy was helpful to assist diagnosis and assess tumor persistence after surgery and its response to topical treatment with imiquimod. Read More

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http://dx.doi.org/10.1111/dth.13048DOI Listing
September 2019
5 Reads

OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study.

Photodiagnosis Photodyn Ther 2019 Sep 27;27:481-486. Epub 2019 Jul 27.

UCL Medical School, London, UK; Unit of OMFS, UCL Eastman Dental Institute, London, UK.

Background: Optical coherence tomography (OCT) has been shown to reliably identify skin changes with the combined advantage of resolution and penetration depth. The objective of this study was to assess the accuracy of OCT in diagnosing various skin pathologies, using pre-set diagnostic criteria, by two reviewers blinded to the actual diagnosis.

Patients And Methods: This immediate ex-vivo study included skin specimens from 103 patients with suspicious skin lesions. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.07.019DOI Listing
September 2019
6 Reads

Pigmented Actinic Keratosis: Case Report and Review of an Uncommon Actinic Keratosis Variant that can Mimic Melanoma.

Cureus 2019 May 22;11(5):e4721. Epub 2019 May 22.

Dermatology, San Diego Family Dermatology, National City, USA.

Pigmented actinic keratosis is an uncommon variant of actinic keratosis that can mimic melanocytic lesions. A 54-year-old man who presented with a dark lesion on his nasal tip is described; biopsy of the lesion revealed a pigmented actinic keratosis that was treated with cryotherapy using liquid nitrogen. Pigmented actinic keratoses typically appear on sun-exposed areas of the skin as flat hyperpigmented lesions that grow in a centrifugal pattern. Read More

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http://dx.doi.org/10.7759/cureus.4721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650181PMC
May 2019
5 Reads

Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars.

J Eur Acad Dermatol Venereol 2020 Jan 23;34(1):74-81. Epub 2019 Aug 23.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Determining whether repigmentation within or adjacent to lentigo maligna or lentigo maligna melanoma (LM/LMM) scars represents recurrence of melanoma is challenging. The use of reflectance confocal microscopy (RCM) and dermoscopy may aid in differentiating true melanoma recurrence from other causes of repigmentation.

Objectives: To describe the characteristics of repigmentation within or adjacent to LM/LMM scars observable on RCM and dermoscopy. Read More

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http://dx.doi.org/10.1111/jdv.15819DOI Listing
January 2020
4 Reads

Considerations for Timing of Defect Reconstruction in Cutaneous Melanoma of the Head and Neck.

Facial Plast Surg 2019 Aug 17;35(4):404-409. Epub 2019 Jul 17.

Department of Otolaryngology - Head and Neck Surgery, University of Missouri, Columbia, Missouri.

The objective of this study is to identify the incidence and characteristics of cases with positive margins on wide local excision for cutaneous melanoma of the head and neck (CMHN) and therefore provide a potential basis for selectively delaying reconstruction pending final histological clearance of melanoma. A systematic review of English language articles was performed on studies retrieved from PubMed and Web of Science. Original investigations published between July 1999 and June 2018 reporting on margin status of CMHN wide local excision specimens were included in the review. Read More

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http://dx.doi.org/10.1055/s-0039-1693469DOI Listing
August 2019
9 Reads

Is dermoscopy a good tool for the diagnosis of lentigo maligna and lentigo maligna melanoma? A meta-analysis.

Clin Cosmet Investig Dermatol 2019 5;12:403-414. Epub 2019 Jun 5.

Medical School, Universidade do Oeste Paulista (UNOESTE), Presidente Prudente, SP, 19050-680, Brazil.

Dermoscopy is a low-cost examination performed by a dermatologist and good for the diagnosis of pigmented lesions. However, dermoscopy diagnosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM) is still questionable. The objective of this study was to evaluate whether dermoscopy is an effective diagnostic method to diagnose LM/LMM from other pigmented skin lesions, and to identify which are the most frequent dermoscopic criteria associated with LM/LMM For this systematic review and meta-analysis, we used the following descriptors: dermoscopy, lentigo maligna, lentigo maligna melanoma, histopathology; and the following databases to search for articles: Cochrane Collaboration, MEDLINE; PMC (PubMed Central) - NIH (National Institutes of Health), EMBASE (The Excerpt Medical Database), and SCISEARCH, from inception to March 30, 2018. Read More

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http://dx.doi.org/10.2147/CCID.S208717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556474PMC
June 2019
6 Reads

9-mm Surgical margin required for both LM and MIS as diagnosed in real-world community practice.

J Am Acad Dermatol 2019 10 22;81(4):e117-e118. Epub 2019 Jun 22.

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.jaad.2019.06.034DOI Listing
October 2019
5 Reads

Comment on "Comparison of surgical margins for lentigo maligna versus melanoma in situ".

J Am Acad Dermatol 2019 10 21;81(4):e115-e116. Epub 2019 Jun 21.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.05.104DOI Listing
October 2019
14 Reads