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    1063 results match your criteria Lentigo Maligna Melanoma

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    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Chondrosarcomatous Differentiation in a Large Malignant Melanoma of the Scalp.
    Case Rep Med 2016 18;2016:1063569. Epub 2016 Dec 18.
    Castle Hill Hospital, East Yorkshire, UK.
    Background. Divergent differentiation in malignant melanoma is a rare phenomenon, which can lead to delayed diagnosis or misdiagnosis, impacting upon patient treatment and outcome, as well as the understanding of tumour behaviour. Case. Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Jan 7. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland.
    Invasive lentigo maligna melanoma (LMM) and its in situ precursor lentigo maligna (LM) are the most common melanoma types on the head and neck areas (1) . Clinically unsuspected invasion is revealed histologically in 5-52% of LMs (2) . Thus, correct early diagnoses are crucial for determining accurate resection margins and the discussion of sentinel lymph node examination (3) . Read More

    A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures.
    J Eur Acad Dermatol Venereol 2016 Dec 17. Epub 2016 Dec 17.
    Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Read More

    Incidence trends and clinical-pathological characteristics of invasive cutaneous melanoma from 1980 to 2010 in the canton of Zurich, Switzerland.
    Melanoma Res 2016 Dec 6. Epub 2016 Dec 6.
    aDivision of Cancer Epidemiology and Prevention, Epidemiology, Biostatistics and Prevention Institute bCancer Registry Zurich and Zug cDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Read More

    Lifetime UV exposure and Lentigo Maligna Melanoma.
    Br J Dermatol 2016 Dec 7. Epub 2016 Dec 7.
    Department of Dermatology, Warren Alpert Medical School.
    Although ultraviolet light is considered a key factor in the etiology of malignant melanoma (MM), the relationship between sunlight and MM is complex. Intermittent exposure and sunburns are far more predictive of melanoma than chronic exposure, and melanoma can arise in non-sun exposed sites. Furthermore, retrospective studies have shown that outdoor workers exposed to sunlight chronically are not at higher risk of melanoma compared with indoor workers living at the same latitude. Read More

    Follicular Malignant Melanoma: A Rare Morphologic Variant of Melanoma. Report of a Case and Review of the Literature.
    Am J Dermatopathol 2016 Nov 29. Epub 2016 Nov 29.
    *Department of Dermatology, University of Illinois at Chicago, Chicago, IL;†Advanced Dermatology and Mohs Surgery, Batavia, IL; and‡Consolidated Pathology Consultants, Libertyville, IL.
    Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Read More

    Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma.
    Br J Cancer 2017 Jan 29;116(2):253-259. Epub 2016 Nov 29.
    Institute for Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
    Background: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme.

    Methods: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Data from 350 306 SCREEN participants, who had been screened negative for melanoma, were linked to data of the state cancer registry. Read More

    University Hospital Waterford: 5-year experience of cutaneous melanoma.
    Ir J Med Sci 2016 Nov 21. Epub 2016 Nov 21.
    Department of Breast and Endocrine Surgery, University Hospital Waterford, Waterford, Ireland.
    Introduction: The incidence of cutaneous melanoma (CM) continues to rise in Ireland. Despite significant advances in melanoma molecular therapy, surgery remains the mainstay of treatment for CM. The University Hospital Waterford (UHW) prospectively maintained CM registry was established in 2010. Read More

    Desmoplastic melanoma: a challenge for the oncologist.
    Future Oncol 2017 Feb 12;13(4):337-345. Epub 2016 Oct 12.
    Department of Diagnostic & Clinical Medicine & Public Health, Clinical Pathology Unit, University of Modena & Reggio Emilia, Modena, Italy.
    Aim: To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM).

    Materials & Methods: Analysis of all DM records from 1991 to 2015.

    Results: The most common location of DMs was the head and neck (69%); median age and follow-up were 60. Read More

    Effect of topical imiquimod as primary treatment for lentigo maligna - the LIMIT-1 study.
    Br J Dermatol 2016 Oct 6. Epub 2016 Oct 6.
    Cancer Research UK Clinical Trials Unit, University of Birmingham.
    Background: Topical imiquimod is sometimes used for lentigo maligna (LM) in-situ melanoma instead of surgery, but frequency of cure is uncertain. Pathological complete regression (pCR) is a logical surrogate marker for cure after imiquimod, although residual LM and atypical melanocytic hyperplasia may not be reliably distinguished. A trial comparing imiquimod versus surgery might be justified by a high imiquimod pCR rate. Read More

    In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs Surgeons.
    Dermatol Clin 2016 Oct;34(4):497-504
    Melanoma Unit, Dermatology Department, Hospital Clinic and Institut d'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain.
    Confocal microscopy is a modern imaging device that has been extensively applied in skin oncology. More specifically, for tumor margin assessment, it has been used in two modalities: reflectance mode (in vivo on skin patient) and fluorescence mode (on freshly excised specimen). Although in vivo reflectance confocal microscopy is an add-on tool for lentigo maligna mapping, fluorescence confocal microscopy is far superior for basal cell carcinoma and squamous cell carcinoma margin assessment in the Mohs setting. Read More

    Lentigo Maligna, Macules of the Face, and Lesions on Sun-Damaged Skin: Confocal Makes the Difference.
    Dermatol Clin 2016 Oct;34(4):421-429
    Dermatology, Sydney Melanoma Diagnostic Centre (SMDC), Royal Prince Alfred Hospital, Melanoma Institute Australia, Central Clinical School, Sydney University, Missenden Road, Camperdown, New South Wales 2050, Australia. Electronic address:
    Distinguishing lentigo maligna (LM) and lentigo maligna melanoma (LMM) from background pigmented non-melanoma lesions is challenging. The field of solar damage can obscure clinical assessment, and diagnostic ambiguities are created due to the overlap of the clinical features of LM with other benign lesions. Moreover, margin assessment on histology is limited by the resemblance between melanocytic hyperplasia of actinically damaged skin and scattered atypical melanocytes of LM/LMM. Read More

    Dermatol Clin 2016 Oct;34(4):411-419
    Dermatology Unit, UniMore, via del Pozzo, 71, Modena 41121, Italy.
    Melanomas are a wide range of tumors that differ in their epidemiology, morphology, genetic profile, and biological behavior. They can be grouped as superficial spreading melanoma, lentigo maligna, and nodular melanoma. Reflectance confocal microscopy is useful for the evaluation of skin lesions that are dermoscopically doubtful by increasing diagnostic accuracy and specificity. Read More

    Cutaneous Melanoma in Asians.
    Chonnam Med J 2016 Sep 23;52(3):185-93. Epub 2016 Sep 23.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Read More

    Associations between childhood height and morphologically different variants of melanoma in adulthood.
    Eur J Cancer 2016 Nov 16;67:99-105. Epub 2016 Sep 16.
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:
    Aim Of The Study: Melanoma subtypes have different aetiological characteristics. Child height is positively associated with adult melanoma; however, a clarification of associations with specific melanoma variants is necessary for an improved understanding of risk factors underlying the histologic entities. This study investigated associations between childhood height and future development of cutaneous melanoma variants. Read More

    Segmental neurofibromatosis and cancer: report of triple malignancy in a woman with mosaic Neurofibromatosis 1 and review of neoplasms in segmental neurofibromatosis.
    Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.
    Department of Dermatology, University of California San Diego, San Diego, California.
    BackgroundSegmental neurofibromatosis, referred to as mosaic neurofibromatosis 1, patients present with neurofibromas or café au lait macules or both in a unilateral segment of the body.PurposeA woman with segmental neurofibromatosis and triple cancer (renal cell carcinoma, mixed thyroid carcinoma, and lentigo maligna) is described and cancers observed in patients with segmental neurofibromatosis are reviewed.MethodsPubMed was used to search the following terms, separately and in combination: cancer, malignancy, mosaic, neoplasm, neurofibroma, neurofibromatosis, segment, segmental, tumor. Read More

    Reflectance Confocal Microscopy in Lentigo Maligna.
    Actas Dermosifiliogr 2016 Dec 7;107(10):830-835. Epub 2016 Sep 7.
    Hospital Universitario Fundación de Alcorcón, Madrid, España.
    Lentigo maligna is the most common type of facial melanoma. Diagnosis is complicated, however, as it shares clinical and dermoscopic characteristics with other cutaneous lesions of the face. Reflectance confocal microscopy is an imaging technique that permits the visualization of characteristic features of lentigo maligna. Read More

    Survival and Surgical Outcomes for Pediatric Head and Neck Melanoma.
    JAMA Otolaryngol Head Neck Surg 2017 Jan;143(1):34-40
    Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle.
    Importance: Melanoma in children is rare, accounting for approximately 2% of all pediatric malignant neoplasms. However, for the past 30 years, the incidence of melanoma in those younger than 20 years has been increasing. Location of the primary tumor has been shown to be an important prognostic factor, with melanomas of the scalp and neck conferring a worse prognosis than those originating at other sites. Read More

    Association Between Confocal Morphologic Classification and Clinical Phenotypes of Multiple Primary and Familial Melanomas.
    JAMA Dermatol 2016 Oct;152(10):1099-1105
    Hospital Clinic I Provincial de Barcelona, Universitat de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain4Centro de Investigación Biomédica en Red en Enfermedades Raras, Barcelona, Spain.
    Importance: The improved knowledge of clinical, morphologic, and epidemiologic heterogeneity of melanoma in the context of multiple primary and familial melanomas may improve prevention, diagnosis, and prognosis of melanoma.

    Objective: To characterize reflectance confocal microscopy (RCM) morphologic patterns of melanomas in multiple primary and familial melanomas.

    Design, Setting, And Participants: In this cross-sectional, retrospective study, patients in a hospital-based referral center were recruited from March 1, 2010, through August 31, 2013; data analysis was conducted from September 1, 2013, through May 31, 2014. Read More

    Racial differences in six major subtypes of melanoma: descriptive epidemiology.
    BMC Cancer 2016 Aug 30;16:691. Epub 2016 Aug 30.
    School of Statistics and The center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave., Beijing, 100872, China.
    Background: Melanoma accounts for the majority of skin cancer deaths. It has over thirty different subtypes. Different races have been observed to differ in multiple aspects of melanoma. Read More

    Cutaneous head and neck melanoma (CHNM): A population-based study of the prognostic impact of tumor location.
    J Am Acad Dermatol 2016 Nov 18;75(5):975-982.e2. Epub 2016 Aug 18.
    Oslo Center for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
    Background: Most studies of cutaneous head and neck melanomas (CHNM) have reported poorer survival in CHNM compared with other sites, especially on the scalp/neck.

    Objective: We sought to compare patient and tumor characteristics between CHNM and cutaneous trunk and extremity melanomas and between CHNM locations (face/ear vs scalp/neck, anterior vs posterior), and to study prognostic factors in patients with CHNM.

    Methods: We studied all CHNM (n = 1074) from 8120 cases of cutaneous melanomas diagnosed in Norway in 2008 to 2012. Read More

    Ingenol Mebutate for Lentigo Maligna: A Case Report.
    Dermatology 2016 11;232 Suppl 1:24-8. Epub 2016 Aug 11.
    Department of Dermatology, University Hospital Inselspital, University of Bern, Bern, Switzerland.
    Background: Lentigo maligna (LM) is a melanoma in situ on sun-damaged skin, with a strong predilection to the head and neck area of the elderly. Many therapeutic modalities have been proposed in the treatment of this pathology, including surgery, cryotherapy, radiotherapy and topical imiquimod. Up to date surgical excision remains the treatment of choice with the lowest recurrence rate. Read More

    VivaScope® 1500 and 3000 systems for detecting and monitoring skin lesions: a systematic review and economic evaluation.
    Health Technol Assess 2016 Jul;20(58):1-260
    Background: Skin cancer is one of the most common cancers in the UK. The main risk factor is exposure to ultraviolet radiation from sunlight or the use of sunbeds. Patients with suspicious skin lesions are first examined with a dermoscope. Read More

    Total earlobe reconstruction with a superiorly based preauricular flap.
    An Bras Dermatol 2016 May-Jun;91(3):372-4
    Hospital Garcia de Orta - Almada, Portugal.
    An 86-year-old woman was referred for treatment of a lentigo maligna melanoma on the left earlobe, confirmed by cutaneous biopsy. The resulting surgical defect involved the earlobe's full thickness. The authors outline a simple method for reconstructing the entire lobe in one stage, without grafts, whilst offering a pleasant appearance. Read More

    Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study.
    J Am Acad Dermatol 2016 Oct 16;75(4):698-705. Epub 2016 Jul 16.
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island.
    Background: The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features.

    Objective: We sought to determine trends in diagnosis and clinical features of MIS.

    Methods: Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Read More

    Neuropeptide Y expression in primary cutaneous melanoma.
    J Eur Acad Dermatol Venereol 2016 Jul 18. Epub 2016 Jul 18.
    Department of Medicine and Medical Specialities, Alcalá University, Madrid, Spain.
    Background: Neuropeptide Y (NPY) is involved in the carcinogenesis of different tumours, especially neural crest-derived tumours.

    Objective: The aim of our study is to investigate the expression of NPY on melanoma and its relation with prognostic histological parameters and survival.

    Methods: This is a retrospective observational study of two independent series, with a total of 79 primary melanomas, diagnosed in two independent University Hospitals in Spain, from January 2000 to December 2004. Read More

    Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice.
    J Clin Aesthet Dermatol 2016 Jun 1;9(6):25-30. Epub 2016 Jun 1.
    Private practice of dermatology, West Des Moines, Iowa, and Iowa Pathology Associates, Des Moines, Iowa.
    Introduction: Lentigo maligna is a form of in situ melanoma that occurs commonly on sun-exposed skin of middle-aged to elderly adults. Margin-control surgery offers the highest cure rate for lentigo maligna/lentigo maligna melanoma.

    Materials And Methods: Charts from the authors' private office from the 20-year period from January 1986 to December 2005 were reviewed to identify patients with histologically confirmed lentigo maligna or lentigo maligna melanoma treated by staged excision. Read More

    Epidemiology of Lentigo Maligna and Lentigo Maligna Melanoma in the Netherlands, 1989-2013.
    J Invest Dermatol 2016 Oct 24;136(10):1955-60. Epub 2016 Jun 24.
    Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; Department of Research, Netherlands Comprehensive Cancer Center, Utrecht, The Netherlands. Electronic address:
    Lentigo maligna (LM) is considered a precursor to LM melanoma (LMM). We assessed trends in LM and LMM incidence rates between 1989 and 2013 in the Netherlands, and estimated the risk of an LMM after LM. Data on newly diagnosed LM and LMM were obtained from the Netherlands Cancer Registry and PALGA: Dutch Pathology Registry. Read More

    Extrafacial Lentigo Maligna: A Report on 14 Cases and a Review of the Literature.
    Actas Dermosifiliogr 2016 Oct 11;107(8):e57-63. Epub 2016 May 11.
    Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España; Universidad de Valencia, Valencia, España.
    Lentigo maligna is the most common form of in situ melanoma. It is most often found on the head and neck, and its clinical and dermoscopic features in this location have been extensively described in the literature. We present a series of 14 patients diagnosed with extrafacial lentigo maligna and lentigo maligna melanoma at Hospital General de Valencia and Hospital de Manacor in Spain, and describe the clinical, dermoscopic, and histologic features observed. Read More

    Worse outcome for patients with recurrent melanoma after negative sentinel lymph biopsy as compared to sentinel-positive patients.
    Eur J Surg Oncol 2016 Sep 19;42(9):1420-6. Epub 2016 Apr 19.
    Skin Cancer Center Ruhr-University, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.
    Background: The long-term outcome of patients with melanoma who had recurrence after negative sentinel lymph node (SLN) biopsy has rarely been evaluated systematically.

    Methods: We searched our databases for melanoma patients with SLN biopsy from the end of 1999 and the beginning of 2011. Data was analyzed using uni- and multivariate statistics as well as Kaplan-Meier curves. Read More

    Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma.
    Int J Cancer 2016 Sep 30;139(6):1217-22. Epub 2016 May 30.
    Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
    Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, and tumor characteristics. We also assessed the association of nevus count with melanoma-specific survival. Read More

    Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2'-deoxyguanosine and Nitrotyrosine in Melanoma.
    Anticancer Res 2016 Apr;36(4):1497-506
    Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
    Background/aim: Increased expression and prognostic significance of major redox regulator nuclear factor erythroid-2-related factor (Nrf2) is recognized in many cancers. Our aim was to investigate the role of oxidative stress markers in melanoma.

    Materials And Methods: We characterized the immunohistochemical expression of Nrf2, kelch-like ECH-associated protein 1 (Keap1), BRAF(V600E), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and nitrotyrosine in 36 nevi, 14 lentigo maligna and 71 malignant melanomas. Read More

    [Micrographic surgery of lentigo maligna].
    Ned Tijdschr Geneeskd 2016 ;160:A9827
    Erasmus Medisch Centrum, Rotterdam.
    Lentigo maligna is an in situ melanoma which usually affects sun-damaged skin on the head and neck. In patients with lentigo maligna, the clinically visible demarcation often correlates poorly with the histopathologically confirmed demarcation. The standard treatment for lentigo maligna is excision with at least 5 mm margins. Read More

    Sex differences in the incidence of skin and skin-related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide.
    Int J Dermatol 2016 Sep 24;55(9):939-55. Epub 2016 Mar 24.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Many skin and skin-related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin-related diseases affecting males vs. females, we reviewed published population-based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Read More

    Lentigo Maligna: Keys to Dermoscopic Diagnosis.
    Actas Dermosifiliogr 2016 Jul-Aug;107(6):489-97. Epub 2016 Feb 11.
    Centro de Cáncer de Piel y Cirugía Micrográfica de Mohs, Servicio De Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
    Dermoscopy is a noninvasive technique that improves accuracy in the diagnosis of cutaneous lesions. The recognition and differential diagnosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging, especially in the early stages when there are no distinctive clinical features. Early diagnosis and appropriate treatment can improve prognosis. Read More

    Excision Margins for Melanoma In Situ on the Head and Neck.
    Dermatol Surg 2016 Mar;42(3):327-34
    *Department of Dermatology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; †Department of Dermatology Surgery, University of Texas Southwestern, Dallas, Texas.
    Background: Complete surgical excision of melanoma in situ (MIS) is curative. A 5-mm margin is often taken as the standard primary excision margin despite increasing evidence that this is frequently inadequate for tumor clearance.

    Objective: To calculate the proportion of patients requiring >5 mm margin for clearance and to investigate any patient/lesion characteristics necessitating larger margins. Read More

    Unstable solar lentigo: A defined separate entity.
    Australas J Dermatol 2016 Aug 2;57(3):229-34. Epub 2016 Feb 2.
    Dermatology Department, Mater Misericordiae Health Service, South Brisbane, Queensland, Australia.
    An unstable solar lentigo is a solar lentigo with areas of melanocytic hyperplasia not extending past the margin of the lesion. They are discrete, macular, pigmented lesions arising on sun-damaged skin and a subset of typical solar lentigos. Clinically they differ from usual solar lentigines in often being solitary or larger and darker than adjacent solar lentigines. Read More

    Concordance of handheld reflectance confocal microscopy (RCM) with histopathology in the diagnosis of lentigo maligna (LM): A prospective study.
    J Am Acad Dermatol 2016 Jun 27;74(6):1114-20. Epub 2016 Jan 27.
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
    Background: Reflectance confocal microscopy (RCM) provides real-time noninvasive imaging of cell structure and may be useful in diagnosing lentigo maligna (LM). Few studies have compared performance of RCM with histopathology in diagnosing LM, and specific features influencing RCM interpretation are not well described.

    Objective: We sought to determine concordance rate between RCM and histopathology in the evaluation of suspected LM and to identify factors that may obscure diagnosis. Read More

    Dermoscopic clues to differentiate facial lentigo maligna from pigmented actinic keratosis.
    Br J Dermatol 2016 May 20;174(5):1079-85. Epub 2016 Jan 20.
    Department of Dermatology and Venerology, Non-Melanoma Skin Cancer Unit, Medical University of Graz, Graz, Austria.
    Background: Dermoscopy is limited in differentiating accurately between pigmented lentigo maligna (LM) and pigmented actinic keratosis (PAK). This might be related to the fact that most studies have focused on pigmented criteria only, without considering additional recognizable features.

    Objectives: To investigate the diagnostic accuracy of established dermoscopic criteria for pigmented LM and PAK, but including in the evaluation features previously associated with nonpigmented facial actinic keratosis. Read More

    Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma.
    Dermatol Surg 2016 Feb;42(2):167-75
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
    Background: Mohs micrographic surgery (MMS) with frozen section immunohistochemistry is a treatment option for malignant melanoma in situ (MMIS) and lentigo maligna melanoma (LMM). Melan-A is a cytoplasmic melanocyte immunostain useful on frozen sections but may lack specificity. Microphthalmia transcription factor (MITF) is a more specific nuclear melanocyte immunostain less frequently used in MMS. Read More

    Guidelines of the Brazilian Dermatology Society for diagnosis, treatment and follow up of primary cutaneous melanoma--Part I.
    An Bras Dermatol 2015 Nov-Dec;90(6):851-61
    Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    The last Brazilian guidelines on melanoma were published in 2002. Development in diagnosis and treatment made updating necessary. The coordinators elaborated ten clinical questions, based on PICO system. Read More

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