1,415 results match your criteria Lentigo Maligna Melanoma


[Translated article] Wood's Lamp for Delineating Surgical Margins in Lentigo Maligna and Lentigo Maligna Melanoma.

Actas Dermosifiliogr 2022 Jun 4;113(6):T642-T645. Epub 2022 May 4.

Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain.

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Clinical features associated with the invasive component in lentigo maligna of the head and neck: A retrospective study of 175 cases.

Ann Dermatol Venereol 2022 Jun 20. Epub 2022 Jun 20.

Department of Dermatology, CHU, Bordeaux, France; INSERM U1053, Bordeaux Research in Translational Oncology, Université Bordeaux, Bordeaux, France.

Background: Lentigo maligna (LM) can develop into lentigo maligna melanoma (LMM) with risk of metastatic dissemination. LMM may be underestimated on the basis of the initial biopsy. The invasion may affect both the therapeutic options and the prognosis. Read More

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New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application.

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:38-50

Dermatology Unit, University of Campania, Naples, Italy.

The incidence of non-melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High-resolution non-invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Read More

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Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy proven lentigo maligna.

J Eur Acad Dermatol Venereol 2022 Jun 22. Epub 2022 Jun 22.

Erasmus MC Cancer institute, University Medical Center Rotterdam, The Netherlands, Department of Dermatology.

Background: Lentigo maligna (LM) based on biopsy material might be lentigo maligna melanoma (LMM) after excision.

Objectives: Investigate whether clinical and dermoscopic mapping increases the detection rate of LMM when investigating staged excision specimens of biopsy proven LM.

Methods: Patients with biopsy proven LM planned for staged excision were included. Read More

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From the Cochrane Library: Interventions for Melanoma in Situ, Including Lentigo Maligna.

J Am Acad Dermatol 2022 May 28. Epub 2022 May 28.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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Series of Fourteen Cases of Topical Imiquimod 5% in Lentigo Maligna: Treatment Modalities and Clues for Detecting Recurrences.

Actas Dermosifiliogr 2022 Apr 3;113(4):T407-T412. Epub 2021 Dec 3.

Departamento de Dermatología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España; Unidad de Dermatología Área, Departamento de Medicina Clínica, Universidad Miguel Hernández, Sant Joan de Alicante, Alicante, España.

Topical imiquimod has been used off-label as monotherapy or adjuvant treatment for lentigo maligna. Our aim is to describe treatment modalities, clinical outcomes, and management of recurrence in patients receiving imiquimod for lentigo maligna. Patients from our unit with lentigo maligna or lentigo maligna melanoma treated with imiquimod 5% as monotherapy or in combination with surgery were included in this study. Read More

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Development of patient decision aids for the treatment of lentigo maligna and low-risk basal cell carcinoma.

J Am Acad Dermatol 2022 May 21. Epub 2022 May 21.

Department of Dermatology, Memorial Sloan Kettering Cancer Center, Dermatology Service, New York, New York.

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Variation in second cancer risk by melanoma subtype among survivors.

J Am Acad Dermatol 2022 May 16. Epub 2022 May 16.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland. Electronic address:

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Lentigo Maligna of the head and neck: A retrospective study assessing surgical excision margins in a South African population.

JAAD Int 2022 Jun 28;7:169-176. Epub 2022 Apr 28.

Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town, South Africa.

Background: Lentigo maligna (LM) is a subtype of melanoma in situ that occurs on sun-damaged skin and is associated with significant subclinical extension beyond the clinical margins of the lesion.

Objectives: This study aimed to determine if the standard recommended tumor excision margins for LM are adequate to achieve a 97% clearance rate and if any patient or tumor characteristics warranted wider margins.

Methods: This study is a retrospective chart review of all patients who were diagnosed with LM of the head and neck and treated with staged excision. Read More

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Complex management of lentigo maligna in the setting of chrysiasis, argyriasis, and tattoo using in vivo reflectance confocal microscopy.

J Dermatol 2022 May 5. Epub 2022 May 5.

The Melanoma Institute of Australia, New South Wales, Australia.

Lentigo maligna (LM) can be difficult to diagnose and recurrence is not uncommon. In vivo reflectance confocal microscopy (RCM) improves diagnostic accuracy of LM. LM can be difficult to discern from coexistent metal-induced cutaneous hyperpigmentation (MICH). Read More

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Classification and Staging of Melanoma in the Head and Neck.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234

Division of Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine,- Jacksonville 653-1 West 8th, Street, Jacksonville, FL 32209, USA.

The rates of melanoma continue to rise, with recent estimates have shown that 18% to 22% of new melanoma cases occur within the head and neck in the United States each year. The mainstay of treatment of nonmetastatic primary melanomas of the head and neck includes the surgical resection and management of regional disease as indicated. Thorough knowledge of the classification and staging of melanoma is paramount to evaluate prognosis, determine the appropriate surgical intervention, and assess eligibility for adjuvant therapy and clinic trials. Read More

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Introduction to Head and Neck Melanoma: A Dermatologist's Perspective.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):213-220

Caremount Medical, Poughkeepsie, NY, USA.

Melanoma is often initially evaluated by the dermatologist. A methodical evaluation requires complete history and detailed clinical physical examination and appropriate decisions regarding biopsies. Accurate diagnosis and staging require clinicopathologic correlation and an excellent relationship with the dermatopathologist. Read More

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Series of Fourteen Cases of Topical Imiquimod 5% in Lentigo Maligna: Treatment Modalities and Clues for Detecting Recurrences.

Actas Dermosifiliogr 2022 Apr 4;113(4):407-412. Epub 2022 Mar 4.

Departamento de Dermatología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain; Unidad de Dermatología Área, Departamento de Medicina Clínica, Universidad Miguel Hernández, Sant Joan de Alicante, Alicante, Spain.

Topical imiquimod has been used off-label as monotherapy or adjuvant treatment for lentigo maligna. Our aim is to describe treatment modalities, clinical outcomes, and management of recurrence in patients receiving imiquimod for lentigo maligna. Patients from our unit with lentigo maligna or lentigo maligna melanoma treated with imiquimod 5% as monotherapy or in combination with surgery were included in this study. Read More

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The peculiar dermatoscopic pattern of scalp melanoma.

J Eur Acad Dermatol Venereol 2022 Apr 14. Epub 2022 Apr 14.

First Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Melanomas developing on anatomic sites other than the trunk and extremities have a special pathogenetic and mutational profile, morphologic characteristics and biologic behaviour.

Objective: By retrospectively screening the databases of our centres, we aimed to investigate the dermatoscopic morphology of early scalp melanoma, including in situ and invasive tumours with a Breslow thickness up to 1 mm.

Methods: The databases of three specialized centres for skin cancer diagnosis and management in Greece were retrospectively evaluated to retrieve dermatoscopic images of scalp melanomas. Read More

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Does the morphology of cutaneous melanoma help explain the international differences in survival? Results from 1,578,482 adults diagnosed during 2000-2014 in 59 countries (CONCORD-3).

Br J Dermatol 2022 Mar 29. Epub 2022 Mar 29.

Cancer Survival Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: CONCORD-3 highlighted wide disparities in population-based 5-year net survival during 2000-2014. Clinical evidence suggests marked international differences in the proportion of lethal acral and nodular subtypes.

Objectives: We aim to assess whether the differences in morphology may explain global variation in survival. Read More

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Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma.

Am J Dermatopathol 2022 Jun 21;44(6):416-423. Epub 2022 Mar 21.

Department of Dermatology and the Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands; and.

Abstract: The infiltration of tissue-resident memory (TRM) cells in melanoma correlates with improved survival, suggesting an important role for TRM cells in immunity against melanoma. However, little is known about the presence of TRM cells in nonmalignant and premalignant melanocytic lesions. This study aimed to evaluate the presence of TRM cells in human skin melanocytic lesions, representing the spectrum from healthy skin to metastatic melanoma. Read More

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Wood's Lamp for Delineating Surgical Margins in Lentigo Maligna and Lentigo Maligna Melanoma.

Actas Dermosifiliogr 2022 Jun 16;113(6):642-645. Epub 2021 Dec 16.

Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, España.

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Dermoscopy of external ear melanoma (EEM).

Arch Dermatol Res 2022 Mar 17. Epub 2022 Mar 17.

Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Cracow Branch, Cracow, Poland.

External ear melanoma (EEM) belongs to extremely rare melanoma locations. So far, only single cases of EEM have been described in terms of dermoscopic presentations. This case study report presents dermoscopic patterns of EEM in six patients. Read More

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The Effect of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for Cells Irradiated with Grenz Rays.

Cancers (Basel) 2022 Feb 28;14(5). Epub 2022 Feb 28.

Department of Radiology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.

Grenz-ray therapy (GT) is commonly used for dermatological radiotherapy and has a higher linear energy transfer, relative biological effectiveness (RBE) and oxygen enhancement ratio (OER). GT is a treatment option for lentigo maligna and lentigo maligna melanoma. This study aims to calculate the RBE for DNA double-strand break (DSB) induction and cell survival under hypoxic conditions for GT. Read More

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February 2022

Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna.

Australas J Dermatol 2022 05 9;63(2):e197-e198. Epub 2022 Mar 9.

Faculty of Medicine, University of Queensland, Bri, Queensland, Australia.

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Update on the Diagnosis and Management of Desmoplastic Melanoma.

Actas Dermosifiliogr 2022 Jan 1;113(1):47-57. Epub 2021 Jul 1.

Servicio de Dermatología. Hospital Universitari Germans Trias i Pujol. Badalona, Barcelona, España; Institut d'investigació Germans Trias. Badalona, Barcelona, España; Universitat Autónoma de Barcelona, Barcelona, España.

Desmoplastic melanoma (DM) accounts for 0.4% to 4% of all melanomas. These skin tumors are mainly formed by amelanotic spindled melanocytes immersed in an abundant collagen stroma and are classified as pure when the desmoplastic component accounts for at least 90% of the invasive tumor and as mixed or combined otherwise. Read More

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January 2022

Incidence of Melanoma in the Basque Province of Álava, Spain, From 2015 to 2018: A Descriptive Study.

Actas Dermosifiliogr 2022 Feb 26;113(2):178-182. Epub 2021 Jul 26.

Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, España; Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, España; Biomedical Research Networking Center on Rare Diseases (CIBERER), ISCIII, 28029, Barcelona, España. Electronic address:

Introduction: The incidence of cutaneous melanoma is rising fast, and its prevalence has doubled in the past 3 decades. Detailed local epidemiological information is essential for informing community-based prevention strategies and optimizing hospital resources.

Material And Methods: We included all patients diagnosed with cutaneous melanoma at Hospital Universitario Araba in the Basque province of Álava, Spain, between January 2015 and December 2018. Read More

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February 2022

Extrafacial Lentigo Maligna: A Clinical And Dermoscopic Analysis According to Localization.

Dermatol Pract Concept 2022 Feb 1;12(1):e2022035. Epub 2022 Jan 1.

Dermatology Department, Universidad de Buenos Aires, Argentina.

Introduction: Whether extrafacial lentigo maligna (EFLM) differs clinically and/or dermoscopically according to location has not been analyzed in depth.

Objectives: To evaluate clinical and dermoscopic characteristics regarding different localization in a series of EFLM.

Methods: We conducted a retrospective analysis of clinical and dermoscopic characteristics of 69 histologically proven EFLM retrieved from the database of two private institutions. Read More

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February 2022

Clinical, Dermoscopic, and Histopathologic Aspects of Amelanotic Lentigo Maligna Melanoma.

Dermatol Pract Concept 2021 Oct 1;11(4):e2021137. Epub 2021 Oct 1.

Military Emergency Hospital Sibiu, Dermatology Department, Sibiu, Romania.

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October 2021

Modified Mohs Micrographic Surgery in Lentigo Maligna Treatment: A Series of Six Cases.

Acta Dermatovenerol Croat 2021 Dec;29(3):127-134

Alexandra Zota, MD, Dr. Leventer Centre, Bucharest, Romania;

The surgical approach to lentigo maligna is a challenge to dermatologists, given its clinical and histopathological particularities. Staged excision with paraffin-embedded, permanent sections for histopathological evaluation of surgical margins is an effective treatment of lentigo maligna because it enables complete excision of the tumor, at the same time preserving maximum amount of healthy tissue. We report a case series of 6 patients diagnosed with lentigo maligna who underwent this procedure in our Institution and we describe the procedure we used. Read More

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December 2021

Amelanotic nodular appearance within superficial spreading melanoma.

J Cosmet Dermatol 2021 Dec 27. Epub 2021 Dec 27.

Bagcilar Research and Training Hospital, Department of Pathology, University of Health Sciences, Istanbul, Turkey.

Usual clinical types of malignant melanoma (MM) are lentigo maligna, superficial spreading, nodular, and acral lentiginous MMs. Rarer variants of MM are amelanotic, neurotropic, desmoplastic, metastatic, invisible, pedunculatedmelanoma (PM), or nodal melanoma (NM), which constitute less than 5% of cases. Recognition and discrimination of these variants are important to avoid misdiagnosis of MM. Read More

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December 2021

A review of Mohs micrographic surgery for skin cancer. Part 1: Melanoma and rare skin cancers.

Clin Exp Dermatol 2022 May 22;47(5):833-849. Epub 2022 Feb 22.

Department of Dermatology, Manor Hospital, Walsall Healthcare NHS Trust, Walsall, UK.

Mohs micrographic surgery (MMS) is a precise and effective method commonly used to treat high-risk basal cell carcinoma and squamous cell carcinoma on the head and neck. Although the majority of evidence for MMS relates to keratinocyte cancers, there is published evidence for other types of skin cancer. This review aims to discuss the evidence for using MMS to treat six different types of skin cancer [malignant melanoma, lentigo maligna, dermatofibrosarcoma protuberans, atypical fibroxanthoma (AFX), microcystic adnexal carcinoma and pleomorphic dermal sarcoma (PDS)] particularly in the context of survival rates and cancer recurrence. Read More

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Indoor Tanning and the Risk of Overall and Early-Onset Melanoma and Non-Melanoma Skin Cancer: Systematic Review and Meta-Analysis.

Cancers (Basel) 2021 Nov 25;13(23). Epub 2021 Nov 25.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.

The aim of this study was to examine the association between indoor tanning use and the risk of overall and early-onset (age < 50) melanoma and non-melanoma skin cancer (NMSC). To evaluate the association between indoor tanning and skin cancer, a systematic review of the literature published until July 2021 was performed using PubMed, EMBASE, and MEDLINE. Summary relative risk (RR) from 18 studies with 10,406 NMSC cases and 36 studies with 14,583 melanoma cases showed significant association between skin cancer and indoor tanning (melanoma, RR= 1. Read More

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November 2021

[Micrographic surgery of lentigo maligna 5 years later].

Ned Tijdschr Geneeskd 2021 10 21;165. Epub 2021 Oct 21.

Erasmus MC Kanker Instituut, Rotterdam: Afd. Dermatologie.

Lentigo maligna is an in situ melanoma which usually affects sun-damaged skin on the head and neck. In patients with lentigo maligna, the clinically visible demarcation often correlates poorly with the histopathologically confirmed demarcation. Micrograhic surgery of lentigo maligna offers certainty of the presence of clear histological margins and is at the same time tissue sparing. Read More

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October 2021