Search our Database of Scientific Publications and Authors

I’m looking for a

    1122 results match your criteria Lentigo Maligna Melanoma

    1 OF 23

    Lentigo maligna: diagnosis and treatment.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Institute of Dermatology, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
    Lentigo maligna (LM) is an in situ subtype of melanoma, clinically presenting as a pigmented, asymmetric macule that originates mostly on the head and neck and spreads slowly. The diagnosis may be challenging both for clinicians and pathologists. Dermatoscopy and reflectance confocal microscopy represent a useful tool in the differentiation of LM from other pigmented lesions, such as pigmented actinic keratosis, solar lentigines, seborrheic keratosis and lichen planus-like keratosis. Read More

    A new dermoscopic algorithm for the differential diagnosis of facial lentigo maligna and pigmented actinic keratosis.
    Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.
    Institute of Dermatology, Catholic University of Rome, Rome, Italy.
    The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. Read More

    Treatment for Lentigo Maligna of the Head and Neck: Survey of Practices in Ontario, Canada.
    Dermatol Surg 2018 Mar 13. Epub 2018 Mar 13.
    Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
    Background: Lentigo maligna is an in situ form of cutaneous melanoma that commonly arises on the head and neck. Various surgical and nonsurgical treatment options are available but no randomized trials exist to guide practice.

    Objective: To determine the current treatment practices for lentigo maligna of the head and neck in Ontario, Canada. Read More

    Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma.
    J Dermatol 2018 Feb 11. Epub 2018 Feb 11.
    Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Spain.
    The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Read More

    Variation in the diagnosis and clinical management of lentigo maligna across Europe: a survey study among European Association of Dermatologists and Venereologists members.
    J Eur Acad Dermatol Venereol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
    Background: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion, and comparative studies are lacking. Read More

    Benign and malignant collision tumors of melanocytic skin lesions with hemangioma: Dermoscopic and reflectance confocal microscopy features.
    Skin Res Technol 2018 May 31;24(2):313-317. Epub 2018 Jan 31.
    Division of Dermatology - Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy.
    Background: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates.

    Methods: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex. Read More

    Dermoscopy vs. reflectance confocal microscopy for the diagnosis of lentigo maligna.
    J Eur Acad Dermatol Venereol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Dermatology, University Hospital of St-Etienne, Saint-Etienne, France.
    Background: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques.

    Objective: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. Read More

    Folliculotropism in pigmented facial macules: Differential diagnosis with reflectance confocal microscopy.
    Exp Dermatol 2018 Mar;27(3):227-232
    Dermatology Department, University of Modena and Reggio Emilia, Modena, Italy.
    Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging. Reflectance confocal microscopy (RCM) has been proven to increase diagnostic accuracy of facial lesions. Read More

    TIMPs expression in lentigo maligna÷lentigo maligna melanoma versus aged skin - a review of the literature and personal experience.
    Rom J Morphol Embryol 2017 ;58(3):717-721
    Department of Pathophysiology, "Carol Davila" University of Medicine and Pharmacy, "Prof. Dr. Matei Bals" National Institute of Infectious Diseases, Bucharest, Romania;
    Mechanisms involved in melanoma invasiveness and metastasis are essential to understanding the behavior of this aggressive melanocytic skin cancer. The epithelial-mesenchymal transition (EMT) is considered fundamental for overcoming the in situ stage of melanoma and its proliferation beyond the basal membrane. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are key molecules involved in EMT about whose expression in lentigo maligna (LM) and lentigo maligna melanoma (LMM) little has been studied so far. Read More

    A Population Based Analysis of Melanoma of the External Ear.
    Otol Neurotol 2018 Feb;39(2):e137-e142
    Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.
    Objective: Malignant melanoma accounts for nearly 75% of all skin cancer deaths, and the incidence is on the rise in the United States. External ear melanoma (EEM) is rare, and there is little long-term data regarding the clinical behavior of this melanoma site. This study analyzes the demographic, clinicopathologic, and survival characteristics of EEM. Read More

    Melanoma in patients with GATA2 deficiency.
    Pigment Cell Melanoma Res 2018 Mar 10;31(2):337-340. Epub 2017 Dec 10.
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    GATA2 deficiency is a recently described genetic disorder affecting hematopoietic stem cells and is associated with immunodeficiency, hematologic malignancy, and various cutaneous pathologies including cutaneous tumors. To explore the incidence and clinical course of melanoma in patients with germline GATA2 deficiencies, we conducted a retrospective chart review of 71 such patients and identified two with invasive melanoma. One melanoma was diagnosed early because it was associated with pruritus due to a graft-versus-tumor effect following bone marrow transplantation. Read More

    Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy.
    Sci Rep 2017 Nov 16;7(1):15750. Epub 2017 Nov 16.
    Experimental Dermatology Group, Institute of Medical Biology, A*STAR, 8- Biomedical Grove, Singapore, Singapore.
    A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM). Read More

    Multiple primary melanoma: a single centre retrospective review.
    Melanoma Res 2017 Dec;27(6):638-640
    Department of Dermatology, St James' Hospital, Dublin, Republic of Ireland.
    Prognosis has been shown to be worse for patients with multiple primary melanomas than those with a single melanoma. One recent retrospective study showed that older, white men were at higher risk of multiple primary melanomas. In our institution 2057 melanomas were diagnosed between January 1994 and March 2016. Read More

    Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma.
    JAMA Dermatol 2017 Dec;153(12):1278-1284
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Importance: The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins.

    Objectives: To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins. Read More

    Synchronous conjunctival melanoma and lentigo maligna melanoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):565-567
    Division of Dermatopathology in the Anatomical Pathology Service at Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Lentigo maligna has an extensive and neoplastic character. It typically progresses slowly and may eventually develop into an invasive melanoma, which is called lentigo maligna melanoma. Ocular melanoma is the second most common type of melanoma. Read More

    Recurrence Rate of Melanoma in Situ when Treated with Serial Disk Staged Excision: A Case Series.
    J Clin Investig Dermatol 2017 Feb 27;5(1). Epub 2017 Feb 27.
    Department of Dermatology, Dermatologic and Mohs Micrographic Surgery Center, San Diego School of Medicine, University of California.
    Background: Cutaneous melanoma is one of the fastest rising cancer diagnoses in recent years. Melanoma in situ (MIS) constitutes a large proportion of all diagnosed melanomas. While surgical excision is considered the standard of therapy, the literature is not clear on which surgical technique minimizes local recurrence. Read More

    Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):458-461. Epub 2017 Jul 19.
    Department of Anesthesiology & Intensive Care Medicine, Emergency Medicine & Pain Management, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067, Dresden, Germany.
    Background: Lentigo malignant melanoma is a melanoma subtype of chronic sun-damaged skin in elderly Caucasians. Amelanotic variants of lentigo malignant are extremely rare.

    Case Presentation: This is a case report of an 80-year-old male patient who presented with a non-pigmented exophytic tumour of his bald head. Read More

    Melanoma subtypes demonstrate distinct PD-L1 expression profiles.
    Lab Invest 2017 09 24;97(9):1063-1071. Epub 2017 Jul 24.
    Department of Dermatology, Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy, and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
    PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic and predictive biomarker in patients with cutaneous melanoma, a finding closely related to its adaptive (IFN-γ-mediated) mechanism of expression. Approximately 35% of cutaneous melanomas express PD-L1, however, the expression patterns, levels, and prevalence in rarer melanoma subtypes are not well described. We performed immunohistochemistry for PD-L1 and CD8 on 200 formalin-fixed paraffin-embedded specimens from patients with acral (n=16), mucosal (n=36), uveal (n=103), and chronic sun-damaged (CSD) (n=45) melanomas (24 lentigo maligna, 13 'mixed' desmoplastic, and 8 'pure' desmoplastic melanomas). Read More

    Patients' Characteristics, Histopathological Findings, and Tumor Stage in Different Types of Malignant Melanoma: A Retrospective Multicenter Study.
    Acta Med Iran 2017 May;55(5):316-323
    Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AND Universal Scientific Education and Research Network (USERN), Tehran, Iran.
    Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histopathological findings. Read More

    Dermoscopy of Pigmented Actinic Keratosis of the Face: A Study of 232 Cases.
    Actas Dermosifiliogr 2017 Nov 11;108(9):844-851. Epub 2017 Jul 11.
    Department of Dermatology, University Hospital Hassan II, Fez, Morocco.
    The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna.

    Objective: To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients.

    Methods: Descriptive and analytical study of 232 PAK. Read More

    Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour.
    J Cutan Med Surg 2018 Jan/Feb;22(1):51-57. Epub 2017 Jul 7.
    1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
    Amelanotic lentigo maligna melanoma represents <2% of melanomas. Diagnosis is delayed owing to the lack of lesion pigmentation and advanced disease at presentation. Excision with appropriate margins is the treatment standard, but the starting point for such margins is often unclear. Read More

    Handheld reflectance confocal microscopy to aid in the management of complex facial lentigo maligna.
    Cutis 2017 May;99(5):346-352
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, and Department of Dermatology, Weill Cornell Medical College, New York, USA.
    Diagnosis and management of lentigo maligna (LM) and LM melanoma (LMM) is challenging. Novel noninvasive imaging technologies such as reflectance confocal microscopy (RCM) have advanced the ability to better diagnose and monitor challenging lesions. In addition, the new handheld RCM (HRCM) together with the use of videomosaics has allowed an accurate evaluation of large lesions in concave/convex areas of the body (eg, the face). Read More

    Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib.
    J Drugs Dermatol 2017 May;16(5):508-511

    The Food and Drug Administration approved Ruxolitinib in 2011 for the treatment of primary myelofibrosis. Five-year safety data showed a higher incidence of skin cancer in patients treated with Ruxolitinib compared to best available therapy for myelofibrosis. This report presents a series of five patients with history of myelofibrosis treated with Ruxolitinib who subsequently developed numerous skin cancers with aggressive biological behavior. Read More


    Histopathologic and Immunohistochemical Correlates of Confocal Descriptors in Pigmented Facial Macules on Photodamaged Skin.
    JAMA Dermatol 2017 Aug;153(8):771-780
    Department of Dermatology, Hospital del Mar-Parc de Salut Mar, Univesitat Autònoma de Barcelona, Barcelona, Spain.
    Importance: Pigmented facial macules on photodamaged skin are a clinical, dermoscopic, and histopathologic challenge.

    Objectives: To clinically and dermoscopically characterize, by means of reflectance confocal microscopy (RCM), ambiguous pigmented facial macules and establish a correlation between RCM, histopathologic, and immunohistochemical findings.

    Design, Setting, And Participants: A prospective study of ambiguous pigmented facial macules on photodamaged skin was conducted in a tertiary referral center for dermatology between January 1, 2009, and December 31, 2015. Read More

    Lentigo maligna melanoma with a history of cosmetic treatment: Prevalence, surgical outcomes and considerations.
    Lasers Surg Med 2017 Nov 29;49(9):819-826. Epub 2017 May 29.
    Memorial Sloan Kettering Cancer Center, Dermatology Service, 16 E. 60th Street, 4th Floor Dermatology, New York, New York, 10022.
    Introduction: Lentigo maligna (LM) is melanoma in situ on sun-damaged skin and presents diagnostic challenges due to overlapping features with benign pigmented lesions. Cosmetic treatments may be inadvertently performed on LM. The aim of this study is to estimate the prevalence of LM with prior cosmetic treatment, and evaluate surgical outcomes. Read More

    Topography of Protein Kinase C βII in Benign and Malignant Melanocytic Lesions.
    Int J Surg Pathol 2017 Sep 24;25(6):497-501. Epub 2017 Apr 24.
    2 Laboratory of Pathology, Division of Morphology, University of Crete, Heraklion, Greece.
    Background: Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro.

    Objective: To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations.

    Methods: Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry. Read More

    Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules.
    Dermatol Surg 2017 Jul;43(7):911-919
    *Department of Dermatology, Paracelsus Medical University of Salzburg, Salzburg, Austria; †Department of Dermatology, Medical University of Graz, Graz, Austria, Europe.
    Background: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.

    Objective: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.

    Patients And Methods: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together. Read More

    Malignant Melanoma in African-Americans: A Population-Based Clinical Outcomes Study Involving 1106 African-American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988-2011).
    Medicine (Baltimore) 2017 Apr;96(15):e6258
    aDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ bSaint George's University School of Medicine, Grenada, West Indies cDepartment of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ dDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ.
    Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Read More

    Elongated Dorsal Nasal Flap to Reconstruct Large Defects of the Nose.
    Dermatol Surg 2017 Aug;43(8):1036-1041
    *All authors are affiliated with the Department of Dermatology, University Clinic of Navarra, Pamplona, Spain.
    Background: The typical reconstructive option for closing large-sized defects of the distal half of the nose is the paramedian forehead flap. Other alternatives are a melolabial interpolation flap and bilobed or trilobed flaps. The dorsal nasal (Rieger) flap is suitable for closing small-sized defects at this location, especially when they are medially located. Read More

    Tumoral Melanosis Associated with Pembrolizumab-Treated Metastatic Melanoma.
    Cureus 2017 Feb 13;9(2):e1026. Epub 2017 Feb 13.
    Department of Dermatology, University of California, San Diego.
    Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. Read More

    Reconstruction of Combined Upper and Lower Eyelid Defects in a Patient With Lentigo Maligna.
    Dermatol Surg 2017 05;43 Suppl 1:S111-S114
    *Department of Ophthalmology, Hospital de l´Espearnça, Parc de Salut Mar, Barcelona, Spain; †Department of Dermatology, Hospital Universitario de Donostia, San Sebastian, Spain; and ‡Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.

    Correlation between digital epiluminescence microscopy parameters and histopathological changes in lentigo maligna and solar lentigo: A dermoscopic index for the diagnosis of lentigo maligna.
    J Am Acad Dermatol 2017 Feb 26;76(2):234-243. Epub 2016 Oct 26.
    Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Luigi Maria Monti (IRCCS-FLMM), Rome, Italy.
    Background: The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult.

    Objective: Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new model of LM dermoscopic progression based on a study of DELM-histopathological correlation.

    Methods: A total of 167 consecutive doubtful pigmented lesions of the head (105 LM and 62 SL/SK) were studied. Read More

    Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery.
    Dermatol Surg 2017 Jun;43(6):792-797
    *Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Various studies have reported local recurrence (LR) rates after surgical treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM). However, the time to LR of LM/LMM is not currently known, as few studies report time to LR and have long-term follow-up.

    Objective: To define time to LR in LM/LMM after surgical treatment, and to describe features of observed LR. Read More

    Characteristic features of cutaneous melanoma in a dermatology referral centre in Tehran, Iran.
    Australas J Dermatol 2017 Nov 15;58(4):e228-e231. Epub 2017 Mar 15.
    Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background/objectives: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran.

    Methods: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Read More

    Diagnosis and management of lentigo maligna: an observational study comparing 2005 with 2014 data in one institution.
    Clin Exp Dermatol 2017 Apr 22;42(3):320-323. Epub 2017 Feb 22.
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
    The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. Read More

    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Apr 20;42(3):266-275. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Clinical and pathologic factors associated with subclinical spread of invasive melanoma.
    J Am Acad Dermatol 2017 Apr 28;76(4):714-721. Epub 2017 Jan 28.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Indications to treat invasive melanoma with Mohs micrographic surgery (MMS) or analogous techniques with exhaustive microscopic margin assessment have not been defined.

    Objective: Identify clinical and histologic factors associated with subclinical spread of invasive melanoma.

    Methods: This retrospective, cross-sectional study evaluated 216 invasive melanomas treated with MMS and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Chondrosarcomatous Differentiation in a Large Malignant Melanoma of the Scalp.
    Case Rep Med 2016 18;2016:1063569. Epub 2016 Dec 18.
    Castle Hill Hospital, East Yorkshire, UK.
    . Divergent differentiation in malignant melanoma is a rare phenomenon, which can lead to delayed diagnosis or misdiagnosis, impacting upon patient treatment and outcome, as well as the understanding of tumour behaviour. . Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Apr 7;76(4):707-713. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures.
    J Eur Acad Dermatol Venereol 2017 Apr 23;31(4):616-624. Epub 2017 Jan 23.
    Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Read More

    Incidence trends and clinical-pathological characteristics of invasive cutaneous melanoma from 1980 to 2010 in the Canton of Zurich, Switzerland.
    Melanoma Res 2017 04;27(2):145-151
    aDivision of Cancer Epidemiology and Prevention, Epidemiology, Biostatistics and Prevention Institute bCancer Registry Zurich and Zug cDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Read More

    1 OF 23