1,193 results match your criteria Lentigo Maligna Melanoma


Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: Evaluation of a series of 41 cases.

Australas J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology Service, Hospital Fundación de Alcorcón, Madrid, Spain.

Background/objectives: Lentigo maligna is usually located on the face. Extrafacial lentigo maligna is less common, and diagnosis of early forms is very difficult. Confocal microscopy of facial and extrafacial lentigo maligna shares the same features (abundant dendritic cells and generalised atypical junctional thickenings) and helps us to identify the dermoscopic features of extrafacial lentigo maligna. Read More

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http://dx.doi.org/10.1111/ajd.13051DOI Listing

A Collision Tumor: Reflectance Confocal Microscopy Features and Correlation between Dermoscopy and Histopathology.

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/155/254153
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http://dx.doi.org/10.4103/ijd.IJD_278_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440176PMC
April 2019
2 Reads

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

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http://dx.doi.org/10.1159/000496539DOI Listing
April 2019
4 Reads

Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition.

Photochem Photobiol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, Dermatology Unit, University of Modena & Reggio Emilia, Modena, Italy.

In vivo reflectance confocal microscopy (RCM) is a noninvasive high-resolution skin imaging tool that has become an important adjunct to clinical exam, dermoscopy and histopathology assessment, in the diagnosis and management of pigmented macules of the face. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging and RCM improves the diagnostic accuracy in the differential diagnosis of LM with other macules of the face such as solar lentigo (SL), pigmented actinic keratosis (PAK), seborrheic keratosis (SK) and lichen planus-like keratosis (LPLK). Here we review the state-of-the-art of RCM morphologic descriptors, standardized terminology, and diagnostic algorithms for the RCM assessment of pigmented macules of the face including melanocytic, and nonmelanocytic lesions. Read More

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http://dx.doi.org/10.1039/c8pp00525gDOI Listing
April 2019
2 Reads

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma.

Cancer Med 2019 Apr 1. Epub 2019 Apr 1.

Prognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society, Kumamoto, Japan.

Background: The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported.

Objectives: To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors.

Methods: Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. Read More

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http://dx.doi.org/10.1002/cam4.2110DOI Listing
April 2019
2 Reads

Melanoma on Chronically Sun Damaged Skin: Lentigo Maligna and Desmoplastic Melanoma.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, University of Connecticut Health Center, Farmington, CT.

There are multiple, genetically distinct pathways that give rise to melanoma. Melanomas on sun damaged skin (MSDS) - including lentigo maligna (LM) and desmoplastic melanoma (DM) - have distinct genetic profiles and are uniquely linked to chronic ultraviolet (UV) exposure. In this article we discuss the etiologies of LM and DM, emerging diagnostic adjuncts that may be helpful in accurately identifying these lesions, and the clinical relevance of their frequent co-occurrence. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.066DOI Listing
March 2019
2 Reads

Surgical Management of Localized Melanoma: A National Cancer Database Retrospective Review.

Br J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Rutgers New Jersey Medical School, Newark, NJ, USA.

Mohs micrographic surgery (MMS) for melanoma remains controversial. Currently, no published clinical trials have examined the role of MMS versus wide local excision (WLE) for melanoma, despite the fact that the use of MMS for melanoma is increasing in the United States. The limited retrospective data that does exist demonstrates MMS as an equally effective modality for the management of melanoma in-situ, lentigo maligna melanoma, and cutaneous head and neck melanomas. Read More

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http://dx.doi.org/10.1111/bjd.17901DOI Listing
March 2019
1 Read

Is melanocyte density our last hope? Comparison of histologic features of photodamaged skin and melanoma in situ after staged surgical excision with concurrent scouting biopsies.

J Cutan Pathol 2019 Mar 23. Epub 2019 Mar 23.

Division of Dermatology, Department of Medicine, Loyola University Chicago Stritch School of Medicine.

How much is too much? How much is not enough? These questions frequently come to mind when performing and examining a staged excision for a malignant pigmented lesion. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/cup.13462DOI Listing

Histologic predictors of invasion in partially biopsied lentigo maligna melanoma.

J Am Acad Dermatol 2019 Apr 26;80(4):1150-1152. Epub 2018 Oct 26.

Research Unit EA 4340 Biomarkers in Cancerology and in Hemato-oncology, University of Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, Boulogne-Billancourt, France; Department of Dermatology, Ambroise Paré Hospital, Boulogne-Billancourt, France.

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http://dx.doi.org/10.1016/j.jaad.2018.10.036DOI Listing

Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters.

Dermatol Pract Concept 2019 Jan 31;9(1):54-62. Epub 2019 Jan 31.

Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.

Background: mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as a therapeutic target in advanced melanoma, their prognostic value is still debated.

Objective: To assess mutation status in primary, recurrent, or metastatic MM and its correlations with histopathological findings. Read More

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http://dx.doi.org/10.5826/dpc.0901a13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368075PMC
January 2019
1 Read

Ten Years experience using the Johnson Square Procedure for Lentigo Maligna.

Br J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, NHS Treatment Centre, Nottingham, UK.

Lentigo maligna (LM) accounts for 4-15% of all melanomas with risk of progression to lentigo maligna melanoma (LMM) estimated to be as high as 20% or as low as 5%. Due to the size, location and sub-clinical spread of these lesions, margin control can be difficult. Clearance rates 24-70% have been reported when using standard excision with 5mm margins and bread-loaf histological processing Recurrence rates of 7-20%. Read More

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http://doi.wiley.com/10.1111/bjd.17774
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http://dx.doi.org/10.1111/bjd.17774DOI Listing
February 2019
4 Reads

Spontaneous Hair Repigmentation in an 80-Year-Old Man: A Case of Melanoma-Associated Hair Repigmentation and Review of the Literature.

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Geisel School of Medicine at Dartmouth, Hanover, NH.

Spontaneous hair repigmentation of physiologically white or gray hair is a rare occurrence that may be associated with melanoma in elderly individuals. We present the first case of this phenomenon in a man. A gray-haired, 80-year-old man presented to dermatology clinic with a 3-cm lock of black hair on his vertex scalp that developed over 1 year. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001353DOI Listing
January 2019
12 Reads

Nine per cent of biopsy-proven lentigo maligna lesions are reclassified as lentigo maligna melanoma after surgery.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/bjd.17714DOI Listing
February 2019

Long-term outcomes of imiquimod-treated lentigo maligna.

Clin Exp Dermatol 2019 Jan 20. Epub 2019 Jan 20.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Background: Lentigo maligna (LM) may be disfiguring and can progress to LM melanoma. Surgical excision remains the mainstay of treatment, but may result in disfigurement when used for large facial lesions. Topical imiquimod is a nonsurgical alternative although data on its long-term efficacy remain limited. Read More

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http://doi.wiley.com/10.1111/ced.13896
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http://dx.doi.org/10.1111/ced.13896DOI Listing
January 2019
12 Reads

Cheek Cutaneous Melanomas: A Review of 98 Cases.

Ann Plast Surg 2019 Apr;82(4):407-410

From the Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

Background: Most head and neck melanomas occur on the face, with the cheek being the most frequently affected site. So far, small numbers of researches on cheek melanomas have yielded insufficient and controversial results. In this trial, we aimed to define the histopathological and clinical features specific to cheek melanomas and to compare them with other head and neck melanomas by using a large group of patients from a single tertiary center. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001695DOI Listing
April 2019
3 Reads

Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.

Surv Ophthalmol 2018 Dec 20. Epub 2018 Dec 20.

Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Cutaneous melanoma, a potentially lethal malignancy of the periocular skin, represents only a small proportion of the roughly 87,000 new cases of cutaneous melanoma diagnosed annually in the United States. Most of our understanding of melanoma of the eyelid skin is extrapolated from studies of cutaneous melanoma located elsewhere. Recent years have witnessed major breakthroughs in molecular biology and genomics of cutaneous melanoma, some of which have led to the development of targeted therapies. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.12.002DOI Listing
December 2018
7 Reads

Epidemiological profile of primary cutaneous melanoma over a 15-year period at a private skin cancer center in Colombia.

Rev Salud Publica (Bogota) 2018 Mar-Apr;20(2):226-231

AA: MD. Oncologist Dermatologist Universidad Nacional de Colombia, Universidad Javeriana. Instituto Nacional de Cancerología. Bogotá, Colombia.

Objective : To describe clinical, histopathological and treatment characteristics of melanoma in a private institution of Bogotá, Colombia, and to identify differences regarding sex and age.

Materials And Methods : Observational, retrospective study. 415 medical records between January 1999 and May 2014 were analyzed. Read More

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https://revistas.unal.edu.co/index.php/revsaludpublica/artic
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http://dx.doi.org/10.15446/rsap.V20n2.65616DOI Listing
June 2017
14 Reads

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.

Int J Dermatol 2019 May 13;58(5):577-581. Epub 2018 Dec 13.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.

Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).

Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.

Results: Although for the global period LM/LMM represented only 8. Read More

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http://dx.doi.org/10.1111/ijd.14334DOI Listing
May 2019
14 Reads

A tiny facial pigmented macule: overcoming the diagnostic challenge.

Dermatol Pract Concept 2018 Oct 31;8(4):322-323. Epub 2018 Oct 31.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

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http://dx.doi.org/10.5826/dpc.0804a15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246060PMC
October 2018
4 Reads

Introduction to reflectance confocal microscopy and its use in clinical practice.

JAAD Case Rep 2018 Nov 10;4(10):1014-1023. Epub 2018 Nov 10.

Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.

Reflectance confocal microscopy (RCM) is a novel technology that provides noninvasive, in vivo imaging of the skin at nearly histologic resolution. In 2016, the US Centers for Medicare and Medicaid Services (CMS) established reimbursement codes for RCM image acquisition and for the reading and interpretation of images. The combination of RCM imaging with dermoscopy has improved the accuracy of skin cancer diagnosis while reducing the number of biopsies of benign skin lesions. Read More

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http://dx.doi.org/10.1016/j.jdcr.2018.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232695PMC
November 2018
13 Reads

Gender differences, UV exposure and risk of lentigo maligna in a nationwide healthcare population cohort study.

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA.

Background: Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence.

Objective: To examine the association of UV light with LM by gender remains unclear. Read More

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http://doi.wiley.com/10.1111/jdv.15348
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http://dx.doi.org/10.1111/jdv.15348DOI Listing
November 2018
13 Reads

Management of Early-Stage Melanoma.

Facial Plast Surg Clin North Am 2019 Feb;27(1):35-42

Department of Dermatology, University of Michigan Medical School, University of Michigan, 1500 East Medical Center Drive, UH South Room F7680, Ann Arbor, MI 48109-5218, USA. Electronic address:

Melanoma is a potentially aggressive skin cancer with a steadily rising incidence. Most melanomas are diagnosed at an early stage and associated with an excellent prognosis when treated appropriately. Primary treatment for melanoma is surgical. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647406183006
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http://dx.doi.org/10.1016/j.fsc.2018.08.003DOI Listing
February 2019
40 Reads

Guidelines of care for the management of primary cutaneous melanoma.

J Am Acad Dermatol 2019 01 1;80(1):208-250. Epub 2018 Nov 1.

American Academy of Dermatology, Rosemont, Illinois.

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183258
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http://dx.doi.org/10.1016/j.jaad.2018.08.055DOI Listing
January 2019
19 Reads

[Lentigo maligna and lentigo maligna melanoma: a clinicopathologic analysis of twenty-four cases].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):769-774

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.007DOI Listing
October 2018
16 Reads

[Spontaneous numbness along with pre-existing deviations in the pigmentation of the lower lip].

Ned Tijdschr Tandheelkd 2018 Oct;125(10):517-523

A 48-year-old man was referred for an evaluation of deviations in the pigmentation of the lower lip, intra-oral swelling and persistent numbness of the sensory area of the left mental nerve. In 2011, the diagnosis lentigo maligna of the lower lip was missed by histopathology of a biopsy performed elsewhere. In 2016, the numbness of the lower lip and chin was diagnosed by a neurologist as numb chin of unknown cause. Read More

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https://www.ntvt.nl/artikel/125/10/een-spontaan-dove-lip-met
Publisher Site
http://dx.doi.org/10.5177/ntvt.2018.10.18142DOI Listing
October 2018
11 Reads

The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management.

Australas J Dermatol 2018 Oct 9. Epub 2018 Oct 9.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.

Background/objectives: There are limited population-based data documenting the incidence and management of lentigo maligna (LM) and invasive lentigo maligna melanoma (LMM). We report the data on occurrence and management of LM and LMM in an Australian population.

Methods: Prospective collection of incidence and clinician-reported management of melanoma in situ (MIS; n = 450, capped) and localised invasive melanoma (n = 3251) notified to the New South Wales Cancer Registry over 12-months in 2006-2007. Read More

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http://doi.wiley.com/10.1111/ajd.12928
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http://dx.doi.org/10.1111/ajd.12928DOI Listing
October 2018
24 Reads

Follicular involvement is frequent in lentigo maligna: Implications for treatment.

J Am Acad Dermatol 2019 Feb 26;80(2):532-537. Epub 2018 Sep 26.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

Background: Follicular involvement of lentigo maligna (LM) is considered a histopathologic hallmark, but its prevalence and characteristics have not been well defined. The depth of intrafollicular extension by neoplastic melanocytes may have clinical importance in the treatment of LM.

Objective: To describe the prevalence and features of follicular involvement in LM, including depth of follicular growth by melanocytes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183262
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http://dx.doi.org/10.1016/j.jaad.2018.07.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333487PMC
February 2019
3 Reads

Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin.

Clin Exp Dermatol 2019 Apr 27;44(3):300-303. Epub 2018 Sep 27.

Skin Cancer Center Ruhr-University, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.

Recurrence rates of both lentigo maligna (LM) and lentigo maligna melanoma (LMM) following conventional surgery are usually relatively high. We aimed to assess the frequencies of melanocytes in tumour-free margins around LM/LMM using soluble adenylyl cyclase (sAC) immunohistochemistry, and to compare these with those of matched healthy contralateral skin. Using the primary mouse-anti-human sAC antibody R21, we evaluated pan-nuclear melanocytic R21 immunostaining, and found that it was significantly (P < 0. Read More

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http://dx.doi.org/10.1111/ced.13754DOI Listing

Dermoscopy findings of a one mm lentigo maligna.

Dermatol Online J 2018 Sep 15;24(7). Epub 2018 Sep 15.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota Department of Dermatology, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota Department of Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota.

A 66-year-old man presented with a grayish 1mm macule on the left cheek. Dermatoscopic examination revealed annular-granular structures partially surrounding a single follicular ostium. Histopathologic examination demonstrated atypical, confluent single melanocytes at the basal layer with nesting, crowding, and upward migration descending along the hair follicle, consistent with the diagnosis of lentigo maligna (LM). Read More

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September 2018
6 Reads

Clinically amelanotic or hypomelanotic melanoma: Anatomic distribution, risk factors, and survival.

J Am Acad Dermatol 2018 Oct;79(4):645-651.e4

Victorian Melanoma Service, Alfred Health, Melbourne, Australia.

Background: The recognition and diagnosis of clinically amelanotic or hypomelanotic melanoma is a challenge.

Objective: This study aimed to examine the anatomic distribution and risk factors associated with clinically amelanotic or hypomelanotic melanoma and compare the survival of patients with clinically amelanotic or hypomelanotic melanoma with that of patients with pigmented melanoma.

Methods: A prospective cohort study of all cases of primary invasive melanoma managed at a tertiary referral center was performed. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.045DOI Listing
October 2018
2 Reads

Use of immune checkpoint inhibitors prolonged overall survival in a Japanese population of advanced malignant melanoma patients: Retrospective single institutional study.

J Dermatol 2018 Nov 11;45(11):1337-1339. Epub 2018 Sep 11.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised mainly white populations, in which superficial spreading melanoma (SSM) and lentigo maligna melanoma are the major clinical types of melanoma. In contrast, Asians manifest a distinct clinicopathological type of melanoma from that of whites and show much higher frequencies of acral lentiginous melanoma (ALM) and mucosal melanoma, which have been shown to be less susceptible to immune checkpoint inhibitors. Because no comparative studies have been published showing improvement of OS by immune checkpoint inhibitors in Asian melanoma patients, we retrospectively collected the data for 45 melanoma patients treated with checkpoint inhibitors and 24 melanoma patients treated with chemotherapy alone before immune checkpoint inhibitors became available, and compared their OS. Read More

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http://dx.doi.org/10.1111/1346-8138.14637DOI Listing
November 2018
11 Reads

Palpebral cutaneous melanomas: a review of 17 cases from a tertiary center.

Int J Dermatol 2019 Jan 31;58(1):75-79. Epub 2018 Aug 31.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

Background: Melanomas arising from eyelid skin are exceptionally rare, accounting for <1% of eyelid malignancies and all cutaneous melanomas. The aim of this study was to identify the histopathological features and clinical behaviors of the palpebral skin melanoma patients from a single tertiary institution.

Patients And Methods: Seventeen Caucasian patients diagnosed with eyelid cutaneous melanoma were analyzed retrospectively. Read More

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http://dx.doi.org/10.1111/ijd.14212DOI Listing
January 2019
2 Reads

Clinical spectrum of cutaneous melanoma morphology.

J Am Acad Dermatol 2019 Jan 28;80(1):178-188.e3. Epub 2018 Aug 28.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.

Objective: To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features.

Methods: All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Read More

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http://dx.doi.org/10.1016/j.jaad.2018.08.028DOI Listing
January 2019
41 Reads
4.450 Impact Factor

Experience with Treating Lentigo Maligna with Definitive Radiotherapy.

Dermatol Res Pract 2018 15;2018:7439807. Epub 2018 Jul 15.

Melanoma Institute Australia, Poche Centre, Crows Nest, Australia.

Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a histopathology report that records completion of excision. Some patients may not be surgical candidates due to comorbidities, patient preference, impact on function, and cosmesis or they have failed surgery with a positive margin. Read More

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http://dx.doi.org/10.1155/2018/7439807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076978PMC
July 2018
26 Reads

Evaluating the Diagnostic Accuracy of Reflectance Confocal Microscopy to Diagnose Skin Cancer: Protocol for a Prospective, Multicenter Study.

JMIR Res Protoc 2018 Aug 9;7(8):e170. Epub 2018 Aug 9.

Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: In the United Kingdom, 350,000 patients per year are referred to hospital clinics with suspicious moles, and approximately half undergo a biopsy to identify the 5%-10% who require further treatment. If cancer cannot be ruled out clinically and on the basis of biopsy results, the lesion is surgically removed. One type of precancerous mole, called lentigo maligna, is particularly challenging to delineate and treat. Read More

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http://dx.doi.org/10.2196/resprot.9296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107731PMC
August 2018
9 Reads

Cutaneous malignant melanoma incidence and mortality trends in Canada: A comprehensive population-based study.

J Am Acad Dermatol 2019 Feb 6;80(2):448-459. Epub 2018 Aug 6.

Divisions of Dermatology, McGill University, Montréal, Canada. Electronic address:

Background: The incidence of cutaneous malignant melanoma (CMM) is on the rise in many parts of the world. However, there is limited knowledge on the epidemiology of CMM in Canada.

Objective: To conduct a comprehensive population-based study of CMM in Canada. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.07.041DOI Listing
February 2019
7 Reads

Undifferentiated Sarcoma as Intermediate Step in the Progression of Malignant Melanoma to Rhabdomyosarcoma: Histologic, Immunohistochemical, and Molecular Studies of a New Case of Malignant Melanoma With Rhabdomyosarcomatous Differentiation.

Am J Dermatopathol 2019 Mar;41(3):221-229

Department of Pathology and Dermatopathology, Albany Medical College, Albany, NY.

Malignant melanoma (MM) may display highly variable phenotypic diversity, sometimes associated with loss of immunohistochemical melanocytic markers and acquisition of nonmelanocytic lineage of differentiation. Primary cutaneous MM with rhabdomyosarcomatous differentiation is extremely rare with only 5 reported cases in the literature. To date, a chronological progression of a MM to rhabdomyosarcoma has not been conclusively documented. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001236DOI Listing
March 2019
3 Reads

Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream.

Ann Dermatol 2018 Aug 28;30(4):454-457. Epub 2018 Jun 28.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 69-year-old man presented with a black irregular patch on his left cheek. Skin biopsy revealed lentigo maligna melanoma . He was treated via partial excision of the melanoma, followed by the application of 5% imiquimod cream every other night for 6 to 8 hours. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5021/ad.2018.30.
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http://dx.doi.org/10.5021/ad.2018.30.4.454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029957PMC
August 2018
14 Reads

Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis.

Case Rep Pathol 2018 28;2018:9410465. Epub 2018 Jun 28.

Department of Pathology, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis, MO 63104, USA.

Cutaneous spindle cell malignancy is associated with a broad differential diagnosis, particularly in the absence of a known primary melanocytic lesion. We present an unusually challenging patient who presented with clinical symptoms involving cranial nerves VII and VIII and a parotid-region mass, which was S100-positive while lacking in melanocytic pigment and markers. Over a year after resection of the parotid mass, both a cutaneous primary lentigo maligna melanoma and a metastatic CP angle melanoma were diagnosed in the same patient, prompting reconsideration of the diagnosis in the original parotid-region mass. Read More

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http://dx.doi.org/10.1155/2018/9410465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046181PMC
June 2018
3 Reads

PRAME Expression in Melanocytic Tumors.

Am J Surg Pathol 2018 Nov;42(11):1456-1465

Departments of Pathology.

PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is known about PRAME protein expression in melanocytic tumors. In this study we examined the immunohistochemical expression of PRAME in 400 melanocytic tumors, including 155 primary and 100 metastatic melanomas, and 145 melanocytic nevi. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001134DOI Listing
November 2018
19 Reads

Long-term relative survival from melanoma in Germany 1997-2013.

Melanoma Res 2018 Jul 16. Epub 2018 Jul 16.

Institute for Social Medicine and Epidemiology.

Up-to-date melanoma relative survival (RS) estimates and trend analysis facilitate close monitoring of melanoma patients' prognosis. This study aimed to provide recent 5-year and 10-year RS from melanoma, stratified by prognostic factors, and identify latest survival trends. Data from 12 German cancer registries were analysed. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000482DOI Listing
July 2018
7 Reads

Mohs micrographic surgery with melanoma antigen recognized by T cells 1 (MART-1) immunostaining for atypical intraepidermal melanocytic proliferation.

J Am Acad Dermatol 2018 Dec 10;79(6):1109-1116.e1. Epub 2018 Jul 10.

Department of Dermatology, University of Pennsylvania Health System, Philadelphia, Pennsylvania.

Background: The efficacy of Mohs micrographic surgery (MMS) for atypical intraepidermal melanocytic proliferation (AIMP) is unknown.

Objective: To ascertain the frequency of diagnostic change to melanoma (upstaging) and the frequency of local recurrence after MMS for AIMP. A secondary outcome was the frequency of subclinical spread (defined as the requirement for >1 stage of MMS to achieve tumor-free margins). Read More

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http://dx.doi.org/10.1016/j.jaad.2018.06.058DOI Listing
December 2018
11 Reads

Staged margin-controlled excision (SMEX) for lentigo maligna melanoma in situ.

J Surg Oncol 2018 Jul 24;118(1):144-149. Epub 2018 Jun 24.

Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: No consensus exists regarding the best surgical strategy to achieve clear surgical margins while minimizing tissue excision when definitely excising lentigo maligna melanoma in situ (LM). The staged margin controlled excision (SMEX) technique is a modification of the spaghetti technique that allows surgeons to minimize margins and ensure complete excision of LM.

Objectives: Our objectives were twofold: a) to evaluate the effectiveness of SMEX for treatment of LM and b) detail the SMEX technique. Read More

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http://dx.doi.org/10.1002/jso.25109DOI Listing
July 2018
8 Reads

Impact of Dermoscopy and Reflectance Confocal Microscopy on the Histopathologic Diagnosis of Lentigo Maligna/Lentigo Maligna Melanoma.

Am J Dermatopathol 2018 Dec;40(12):884-889

Department of Anatomic Pathology, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

Background: Equivocal pigmented lesions of the head are usually biopsied to avoid inappropriate treatment. Clinical approach has evolved from simple visual examination to sophisticated techniques for selecting the biopsy sites.

Objective: This study aimed to retrospectively evaluate the efficiency of dermoscopy (DE) and reflectance confocal microscopy (RCM) in sampling a histopathologically representative focus of lentigo maligna/lentigo maligna melanoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001212DOI Listing
December 2018
8 Reads

Repair of a Complex Marginal Auricular Defect After Lentigo Maligna Melanoma Excision.

Dermatol Surg 2018 12;44(12):1615-1618

ENT Department, University Clinic Ulm, Ulm, Germany.

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http://dx.doi.org/10.1097/DSS.0000000000001589DOI Listing
December 2018
15 Reads

Treating melanoma in situ and lentigo maligna with Mohs micrographic surgery in Australia.

Australas J Dermatol 2019 Feb 22;60(1):33-37. Epub 2018 Jun 22.

South Perth Specialist Skin Cancer Centre, Perth, Western Australia, Australia.

Background/objectives: There is a paucity of Australian data on the use of Mohs micrographic surgery for treating melanoma in situ and lentigo maligna. We share an Australian centre's experience with the technique.

Methods: A total of 62 patients with 62 lesions of melanoma in situ and lentigo maligna referred for treatment between 2015 and 2017 comprised the study group. Read More

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http://dx.doi.org/10.1111/ajd.12845DOI Listing
February 2019
25 Reads

Melanoma: clinical, evolutive and histopathological characteristics of a series of 136 cases.

An Bras Dermatol 2018 Jun;93(3):373-376

Department of Pathology, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged.

Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001085PMC
June 2018
5 Reads

Association between Breslow thickness and dermoscopic findings in acral melanoma.

J Am Acad Dermatol 2018 Nov 13;79(5):831-835. Epub 2018 Jun 13.

Department of Dermatology, Pusan National University College of Medicine, Busan, South Korea; Medical Research Institute, Pusan National University Hospital, Busan, South Korea. Electronic address:

Background: Dermoscopy is a useful tool for the diagnosis of acral melanomas (AMs). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM.

Objective: To investigate the affect Breslow thickness (BT) has on the dermoscopic patterns of AM. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.06.004DOI Listing
November 2018
4 Reads