1,339 results match your criteria Lentigo Maligna Melanoma

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).

Jpn J Clin Oncol 2021 Jun 12. Epub 2021 Jun 12.

Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

Background: Nivolumab, the anti-programmed cell death protein 1 antibody, has been approved for advanced melanoma, mainly based on evidence from Western countries. The profile of melanoma differs between Caucasian and Asian patients. This study was performed to obtain post-marketing data of nivolumab in Japanese patients with advanced melanoma. Read More

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Melanoma In Situ: A Critical Review and Re-Evaluation of Current Excision Margin Recommendations.

Adv Ther 2021 May 28. Epub 2021 May 28.

Melanoma Institute Australia, The University of Sydney, 40 Rocklands Road, North Sydney, NSW, 2060, Australia.

Most international clinical guidelines recommend 5-10 mm clinical margins for excision of melanoma in situ (MIS). While the evidence supporting this is weak, these guidelines are generally consistent. However, as a result of the high incidence of subclinical extension of MIS, especially of the lentigo maligna (LM) subtype, wider margins will often be needed to achieve complete histologic clearance. Read More

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Risk factors for cardiovascular mortality and melanoma-specific mortality among patients with melanoma: a SEER based study.

Eur J Cancer Prev 2021 May 18. Epub 2021 May 18.

Faculty of Medicine, Alexandria University, Alexandria Faculty of Medicine, Al-Azhar University, Assiut Faculty of Medicine, Fayoum University, Fayoum Faculty of Medicine, Assiut University, Assiut, Egypt.

Objective: This study aims to identify the risk factors for cardiovascular mortality in melanoma patients.

Methods: Data of melanoma patients were obtained from the Surveillance, Epidemiology, and End Results database. We used Person's chi-square test to assess the relationships between categorical variables. Read More

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Lentigo maligna: defining margins and predictors of recurrence utilising clinical, dermoscopic, confocal microscopy and histopathology features.

J Eur Acad Dermatol Venereol 2021 May 17. Epub 2021 May 17.

Melanoma Institute Australia (MIA), The University of Sydney, North Sydney, Australia.

Background: Lentigo maligna (LM) is a subtype of melanoma in situ with poorly defined margins and a high recurrence rate. The biological behaviour of LM appears to differ widely between cases, from biologically indolent to biologically active variants, with some patients experiencing multiple recurrences. It is not known whether this is secondary to inadequate margins, field cancerisation or the innate biology of the lesion itself. Read More

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Histopathologic classification and prognostic factors of melanoma: a 2020 update.

Mattheos Bobos

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Department of Biomedical Sciences, School of Health Sciences, Alexandrian Campus, International Hellenic University, Thessaloniki, Greece -

Despite the rapid recent advances in molecular analysis of tumors, which allow large-scale and high-resolution genomics, the "gold standard" for melanoma diagnosis continues to be histopathology, in conjunction with clinical characteristics and sometimes with important support of immunohistochemistry. Observations, where postulated that cutaneous melanomas may arise through two distinct pathways, discoveries such as that BRAFV600E mutations were mostly common in melanomas on sun-exposed skin with little solar elastosis and seminal works for melanoma progression and evolution set the groundwork for the new WHO Classification of Melanoma; a classification of melanoma that not only encompasses histologic but also clinical, epidemiologic, and genetic characteristics. The melanomas were divided into those etiologically related to sun exposure and those that are not, based on their mutational signatures, anatomic site, and epidemiology. Read More

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Systematic review and meta-analysis of local recurrence rates of head and neck cutaneous melanomas after wide local excision, Mohs micrographic surgery, or staged excision.

J Am Acad Dermatol 2021 May 4. Epub 2021 May 4.

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Prospective trials have not compared the local recurrence rates of different excision techniques for cutaneous melanomas on the head and neck.

Objective: To determine local recurrence rates of cutaneous head and neck melanoma after wide local excision (WLE), Mohs micrographic surgery (MMS), or staged excision.

Methods: A systematic review of PubMed, EMBASE, and Web of Science identified all English case series, cohort studies, and randomized controlled trials that reported local recurrence rates after surgery for cutaneous head and neck melanoma. Read More

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Flat scalp melanoma dermoscopic and reflectance confocal microscopy features correspond to histopathologic type and lesion location.

J Eur Acad Dermatol Venereol 2021 May 7. Epub 2021 May 7.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Background: Dermoscopy and Reflectance Confocal Microscopy (RCM) features of scalp melanoma according to lesion location and histopathology have not been fully investigated.

Objectives: To reveal dermoscopic and RCM features of scalp melanoma according to lesion location and histopathology.

Methods: We retrospectively retrieved images of suspicious, atypical excised, flat melanocytic lesions of the scalp, assessed on dermoscopy and RCM at five centres, from June 2007 to April 2020. Read More

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3'UTR-CDKN2A and CDK4 Germline Variants Are Associated With Susceptibility to Cutaneous Melanoma.

In Vivo 2021 May-Jun;35(3):1529-1536

General Dermatology Group, Hospital Universitario Centro Dermatológico Federico Lleras Acosta E.S.E, Bogotá, Colombia

Background/aim: Genetic variations of the CDKN2A and CDK4 gene have been associated to melanoma development. In the present study we investigated the potential associations of CDKN2A and CDK4 gene variants in a colombian population diagnosed with melanoma.

Materials And Methods: DNA was extracted from whole blood samples from 85 patients diagnosed with cutaneous melanoma and 166 healthy controls. Read More

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January 2021

Desmoplastic Melanoma: A Clinicopathological Analysis of Three Cases in the Chinese Population.

Onco Targets Ther 2021 15;14:2651-2660. Epub 2021 Apr 15.

Department of Pathology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200050, People's Republic of China.

Purpose: To investigate the clinicopathological characteristics and immunophenotype of desmoplastic melanoma (DM) in the Chinese population.

Patients And Methods: We report three cases of DM diagnosed by the Pathology Department of Shanghai Dermatology Hospital. We describe the clinical and pathological characteristics of the three cases and examine molecular markers used in the diagnosis of DM. Read More

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Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study.

BMC Cancer 2021 Apr 16;21(1):420. Epub 2021 Apr 16.

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, No. 88, Jiefang Road, Hangzhou, 310009, China.

Background: Previous studies reported cutaneous melanoma in head and neck (HNM) differed from those in other regions (body melanoma, BM). Individualized tools to predict the survival of patients with HNM or BM remain insufficient. We aimed at comparing the characteristics of HNM and BM, developing and validating nomograms for predicting the survival of patients with HNM or BM. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Change in lentigo maligna score assessed by in vivo reflectance confocal microscopy after one month of imiquimod treatment for lentigo maligna management.

J Am Acad Dermatol 2021 Mar 27. Epub 2021 Mar 27.

Nantes University, Department of Dermatology, CHU Nantes, CIC 1413, CRCINA, Nantes university F-44000 Nantes, France. Electronic address:

Background: Treatment of Lentigo Maligna (LM) is challenging because of the potential functional and esthetic surgical sequelae. Imiquimod has been proposed as an alternative treatment for LM. Reflectance Confocal Microscopy (RCM) is a non-invasive tool used for the diagnosis of LM and margin assessment. Read More

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Unusual Morphological Presentation of Cutaneous Malignant Melanoma: A Rare Case Report.

Indian Dermatol Online J 2021 Jan-Feb;12(1):139-141. Epub 2021 Jan 16.

Department of Pathology, Prolife Diagnostics, Bhubaneswar, Odisha, India.

Cutaneous malignant melanoma is a rapidly progressing skin tumor accounting for most deaths from skin malignancies. Four morphological variants (nodular, superficial spreading, lentigo maligna, and acral lentiginous) are described in the literature. Here we are reporting malignant melanoma in a 35-year-old male who presented with depigmented plaques with few hyperpigmented areas and extensive overlying scaling. Read More

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January 2021

Topical Imiquimod for Lentigo Maligna: Survival Analysis of 103 Cases With 17 Years Follow-up.

J Drugs Dermatol 2021 03;20(3):346-348

Topical imiquimod 5% cream has been investigated as off-label primary or adjuvant treatment for melanoma in situ, lentigo maligna type (LM). Herein, we present the largest known case series of lentigo maligna treated with topical imiquimod, with up to 17 years of follow-up, and include a recurrence-free survival analysis. In this case series, 103 lesions were retrospectively evaluated for treatment response and recurrence following a course of topical imiquimod with or without tazarotene gel 0. Read More

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Evaluating residual melanocytic atypia in a post-excision scar using in vivo reflectance confocal microscopy.

Skin Res Technol 2021 Mar 2. Epub 2021 Mar 2.

Center for Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ, USA.

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Xeroderma pigmentosum in Yemen.

Int J Dermatol 2021 Mar 4;60(3):314-320. Epub 2021 Feb 4.

Department of Dermatology, Saudi Hospital at Hajjah, Sana'a, Republic of Yemen.

Background: The incidence of xeroderma pigmentosum (XP) in Yemen seems to be quite high but there are no previous reports.

Objective: To study the clinicoepidemiologic aspect of XP in Yemen.

Methods: All 40 patients (24 male and 16 female patients from 32 families) treated and followed between 1997 and 2014 were subjected to detailed analysis with the help of a standardized protocol. Read More

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Lentiginous melanoma (lentigo maligna and lentigo maligna melanoma) in Australia: clinicopathological characteristics, management and recurrence rates after 10-year follow-up at a tertiary centre.

J Eur Acad Dermatol Venereol 2021 Jun 3;35(6):1315-1322. Epub 2021 Mar 3.

Sydney Melanoma Diagnostic Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Background: Lentiginous melanoma or lentigo maligna is a slow-growing type of melanoma frequently arising in sun-damaged skin and often first diagnosed in the elderly. Few studies report long-term follow-up.

Objectives: To define characteristics of lentiginous melanoma in situ (LM) and invasive lentiginous melanoma (LMM) in Australian patients managed at a tertiary centre and describe local recurrence or treatment failure rates after long-term follow-up. Read More

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May melanophages hinder the subclinical spread of lentigo maligna and lentigo maligna melanoma? Results from a pilot study.

J Eur Acad Dermatol Venereol 2021 Jun 9;35(6):e365-e367. Epub 2021 Feb 9.

Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.

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In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions.

Sci Rep 2021 Jan 14;11(1):1405. Epub 2021 Jan 14.

Privolzhsky Research Medical University, Minin and Pozharsky Square 10/1, Nizhny Novgorod, Russia, 603950.

There is a wide range of equivocal melanocytic lesions that can be clinically and dermoscopically indistinguishable from early melanoma. In the present work, we assessed the possibilities of combined using of multiphoton microscopy (MPM) and optical coherence angiography (OCA) for differential diagnosis of the equivocal melanocytic lesions. Clinical and dermoscopic examinations of 60 melanocytic lesions revealed 10 benign lesions and 32 melanomas, while 18 lesions remained difficult to diagnose. Read More

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January 2021

Subtyping Cutaneous Melanoma Matters.

JNCI Cancer Spectr 2020 Dec 23;4(6):pkaa097. Epub 2020 Oct 23.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Our aim was to investigate the role of melanoma subtype on survival and focus on the effects stratified by Breslow thickness and ulceration status.

Methods: Patients with cutaneous melanoma stage I, II, or III diagnosed between 2000 and 2014 were derived from the Dutch Nationwide Pathology Registry and overall survival data from the Netherlands Cancer Registry. Patients were followed until 2018. Read More

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December 2020

Skin lesions of face and scalp - Classification by a market-approved convolutional neural network in comparison with 64 dermatologists.

Eur J Cancer 2021 Feb 25;144:192-199. Epub 2020 Dec 25.

Department of Genetic Epidemiology, University of Goettingen, Goettingen, Germany.

Background: The clinical differentiation of face and scalp lesions (FSLs) is challenging even for trained dermatologists. Studies comparing the diagnostic performance of a convolutional neural network (CNN) with dermatologists in FSL are lacking.

Methods: A market-approved CNN (Moleanalyzer-Pro, FotoFinder Systems) was used for binary classifications of 100 dermoscopic images of FSL. Read More

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February 2021

Immunohistochemical study of CD117 in various cutaneous melanocytic lesions.

Exp Ther Med 2021 Jan 26;21(1):78. Epub 2020 Nov 26.

Department of Dermatology, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi 700115, Romania.

The aim of the present study was to carried out a comparative immunohistochemical evaluation of CD117 (c-Kit), a biomarker that evaluates both tumor progression and prognosis, in different melanocytic lesions, to emphasize the significance of this biomarker in malignant melanoma (MM). The study was performed on 55 cases, represented by a control group, which included 5 cases of simple nevi and 5 cases of dysplastic nevi, as well as a study group consisting of 35 cases of primary MM and 10 metastases (one intestinal, 3 cutaneous - one satellite and two distant as well as 6 in the lymph nodes). The study group included 15 cases of superficial spreading melanoma (SSM), 10 cases of nodular melanoma (NM), 3 lentigo maligna melanoma (LMM), 3 cases of acral lentiginous melanoma (ALM) and 4 cases of amelanotic MM. Read More

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January 2021

Diagnostic application of cyclin D1 fluorescent in situ hybridization for histologically undetermined early lesions of acral melanoma in situ: A case series.

Ann Diagn Pathol 2021 Feb 13;50:151681. Epub 2020 Dec 13.

Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Florida, USA.

Histologically undetermined early acral melanoma in situ (HUAMIS) is rare but a diagnostic challenge, being clinically and dermoscopically MIS (late onset, a large size (>7 mm), parallel ridges pattern) but microscopically without recognizable cytological atypia. Cyclin D1 (CCND1) gene amplification is a genetic aberration occurring in the early radial growth phase of AMs and could thus help determine malignancy for this disease. We determine the value of CCND1 amplification by FISH as a diagnostic marker for HUAMIS. Read More

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February 2021

Clinical and Demographic Profile of Cutaneous Melanoma: Pakistani Perspective.

World J Plast Surg 2020 Sep;9(3):296-301

Department of Plastic Surgery, National Institute of Rehabilitation Medicine (NIRM), Islamabad, Pakistan.

Background: Cutaneous melanomas (CMs) account for only a small proportion of skin cancers, however these are responsible for most skin cancer deaths. There has been a consistently increasing trend in their incidence across the globe.

Methods: This prospective case series study spanned over a period of three years. Read More

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September 2020

Dermatoscopy of melanoma according to type, anatomic site and stage: a 2020 update.

G Ital Dermatol Venereol 2020 Dec 14. Epub 2020 Dec 14.

Second Department of Dermatology, Aristotle University, Thessaloniki, Greece.

The indisputable contribution of dermatoscopy in early diagnosis of melanoma is widely recognized. In the last quinquennium, new data concerning specific melanoma subtypes have come to light. The dermatoscopic morphology of superficial spreading melanoma (SSM) has been extensively investigated in the literature. Read More

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December 2020

Surgical procedures in melanoma in 2020: recommended deep and lateral margins, indications for sentinel lymph node biopsy, and complete lymph node dissection.

G Ital Dermatol Venereol 2020 Dec 14. Epub 2020 Dec 14.

Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, València, Spain.

Introduction: Surgery is the main treatment for cutaneous melanoma including the primary melanoma as well as lymph node metastases. The recommended margins have changed over time. Similarly, indications for sentinel lymph node biopsy and complete lymph node dissection are constantly evolving as long as knowledge on the biological behavior of melanomas increases. Read More

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December 2020

PRAME immunohistochemistry as an adjunct for diagnosis and histological margin assessment in lentigo maligna.

Histopathology 2021 Jun 2;78(7):1000-1008. Epub 2021 Apr 2.

Department of Pathology, University of Virginia, Charlottesville, VA, USA.

Aims: Lentigo maligna (LM), the most common type of melanoma in situ, is a diagnostically challenging lesion for pathologists due to abundant background melanocytic hyperplasia in sun-damaged skin. Currently, no laboratory methods reliably distinguish benign from malignant melanocytes. However, preferentially expressed antigen in melanoma (PRAME) has shown promise in this regard, and could potentially be applied to diagnosis and margin assessment in difficult cases of LM. Read More

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Cross-sectional study of pigmented lesions of the head and neck in adults aged 40 years and above.

Australas J Dermatol 2021 May 5;62(2):e267-e271. Epub 2020 Dec 5.

Mater Hospital, South Brisbane, Queensland, Australia.

The diagnosis of junctional and lentiginous naevi on sun-damaged skin of the head and neck in adults has been questioned in the literature, with the implication that these lesions should be classified as melanoma in situ. This could result in the overdiagnosis and overtreatment of non-malignant lesions. We conducted a cross-sectional study of the histopathological diagnosis of pigmented lesions biopsied from the head and neck of adults ≥40 years of age that were submitted to a large, Queensland-based pathology centre over seven months. Read More

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Handheld reflectance confocal microscopy: Personalized and accurate presurgical delineation of lentigo maligna (melanoma).

Head Neck 2021 Mar 24;43(3):895-902. Epub 2020 Nov 24.

Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Background: The surgical treatment of lentigo maligna melanoma is associated with high rates of local recurrence. Handheld reflectance confocal microscopy (HH-RCM) allows for in vivo presurgical detection of subclinical lentigo maligna (melanoma) (LM/LMM).

Methods: A single-center retrospective study from December 2015 to July 2017. Read More

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