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    Protection against summer solar lentigo over-pigmentation with a SPF30 daily cream.
    Skin Res Technol 2018 Feb 15. Epub 2018 Feb 15.
    Pierre Fabre Dermo-Cosmétique, Centre de Recherche sur la Peau, Toulouse, France.
    Background/purpose: The aim of this study was to measure lentigines' pigmentation over a long period of time and evaluate if summer over-pigmentation can be avoided by the use a SPF30 day skin cream.

    Methods: Seventeen healthy female volunteers aged 50 and over and presenting lentigines participated in the study from spring to summer. Throughout the study, all subjects applied a SPF30 daily skin cream to only one hand. Read More

    Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma.
    J Dermatol 2018 Feb 11. Epub 2018 Feb 11.
    Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Spain.
    The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Read More

    Classification of the clinical images for benign and malignant cutaneous tumors using a deep learning algorithm.
    J Invest Dermatol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:
    We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (20,826 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More

    Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase.
    J Invest Dermatol 2018 Feb 7. Epub 2018 Feb 7.
    Front End Innovation, Beiersdorf AG, Hamburg, Germany. Electronic address:
    Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target to inhibit hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were identified using mushroom tyrosinase as the target. Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Read More

    Variation in the diagnosis and clinical management of Lentigo Maligna across Europe: a survey study among EADV members.
    J Eur Acad Dermatol Venereol 2018 Feb 8. Epub 2018 Feb 8.
    Dermatologist, Department of Dermatology, Erasmus Medical Center Rotterdam, The Netherlands.
    Background: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion and comparative studies are lacking. Read More

    Benign and malignant collision tumors of melanocytic skin lesions with hemangioma: Dermoscopic and reflectance confocal microscopy features.
    Skin Res Technol 2018 Jan 31. Epub 2018 Jan 31.
    Division of Dermatology - Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy.
    Background: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates.

    Methods: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex. Read More

    Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

    Dermoscopy vs. reflectance confocal microscopy for the diagnosis of lentigo maligna.
    J Eur Acad Dermatol Venereol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Dermatology, University Hospital of St-Etienne, Saint-Etienne, France.
    Background: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques.

    Objective: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. Read More

    The limitations of dermoscopy: false-positive and false-negative tumours.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

    Wavelet-based statistical classification of skin images acquired with reflectance confocal microscopy.
    Biomed Opt Express 2017 Dec 8;8(12):5450-5467. Epub 2017 Nov 8.
    University of Toulouse, IRIT-INPT, 2 rue Camichel, BP 7122, 31071 Toulouse cedex 7, France.
    Detecting skin lentigo in reflectance confocal microscopy images is an important and challenging problem. This imaging modality has not yet been widely investigated for this problem and there are a few automatic processing techniques. They are mostly based on machine learning approaches and rely on numerous classical image features that lead to high computational costs given the very large resolution of these images. Read More

    Lymphoedema in Lentigo Maligna patients treated with imiquimod, a long term adverse effect.
    Br J Dermatol 2017 Dec 23. Epub 2017 Dec 23.
    Dermatologist, Erasmus Universiteit Medical Center Rotterdam, the Netherlands.
    Lentigo Maligna (LM) is a potential precursor lesion of Lentigo Maligna Melanoma (LMM). It is treated to prevent progression to LMM. A recent epidemiological study reports a progression rate of 2. Read More

    Folliculotropism in pigmented facial macules: Differential diagnosis with Reflectance confocal microscopy.
    Exp Dermatol 2017 Dec 22. Epub 2017 Dec 22.
    Dermatology Department, University of Modena and Reggio Emilia, Italy.
    Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging. Reflectance confocal microscopy (RCM) has been proven to increase diagnostic accuracy of facial lesions. Read More

    Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients.
    J Photochem Photobiol B 2018 Jan 6;178:577-583. Epub 2017 Dec 6.
    Department of Dermato-venerology, Bispebjerg University Hospital, 2400 Copenhagen, Denmark.
    Importance: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.

    Objectives: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines. Read More

    TIMPs expression in lentigo maligna÷lentigo maligna melanoma versus aged skin - a review of the literature and personal experience.
    Rom J Morphol Embryol 2017 ;58(3):717-721
    Department of Pathophysiology, "Carol Davila" University of Medicine and Pharmacy, "Prof. Dr. Matei Bals" National Institute of Infectious Diseases, Bucharest, Romania;
    Mechanisms involved in melanoma invasiveness and metastasis are essential to understanding the behavior of this aggressive melanocytic skin cancer. The epithelial-mesenchymal transition (EMT) is considered fundamental for overcoming the in situ stage of melanoma and its proliferation beyond the basal membrane. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are key molecules involved in EMT about whose expression in lentigo maligna (LM) and lentigo maligna melanoma (LMM) little has been studied so far. Read More

    A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8591
    aDepartment of Medical Genetics, Naval Medical University, Shanghai 200433, ChinabHebei North University, Zhangjiakou, Hebei Province, ChinacDepartment of Gastroenterology, Airforce General Hospital of PLA, Beijing, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. Read More

    A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach: Case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8466
    aDepartment of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinabDepartment of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi, China.
    Rationale: A solitary Peutz-Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach.

    Patient Concerns: A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. Read More

    The association between Solar Lentigines and Type-2 Diabetes.
    Caspian J Intern Med 2017 ;8(4):317-320
    Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
    Background: Limited information exists between the associations of diabetes mellitus (DM) and solar lentigo (SL); a benign, common skin lesion characterized by hyperpigmented macules.

    Methods: This study was conducted on 90 patients diagnosed with DM and their age and sex matched controls who were referred to the Departments of Endocrinology at Babol University of Medical Science in Northern of Iran from January 2013 to December 2015. All demographic data including age, gender, occupation, family history of DM, estimated average sun exposure and presence of skin lesions were collected and analyzed. Read More

    A Population Based Analysis of Melanoma of the External Ear.
    Otol Neurotol 2018 Feb;39(2):e137-e142
    Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.
    Objective: Malignant melanoma accounts for nearly 75% of all skin cancer deaths, and the incidence is on the rise in the United States. External ear melanoma (EEM) is rare, and there is little long-term data regarding the clinical behavior of this melanoma site. This study analyzes the demographic, clinicopathologic, and survival characteristics of EEM. Read More

    Histopathological diagnosis of small melanocytic lesions suspicious for malignant melanoma.
    An Bras Dermatol 2017 May-Jun;92(3):375-378
    Department of Pathology - School of Medicine at Universidade Federal do Rio de Janeiro (UFRJ) - Rio de Janeiro (RJ), Brazil.
    The concern about malignant skin neoplasms leads to the excision of smaller lesions. This study on small melanocytic lesions aims to evaluate the range of possible histopathological diagnoses, describe histopathological aspects, and assess the usefulness of serial histological sections. We performed a cross-sectional descriptive histopathological study examining 76 pigmented skin lesions up to 6 mm in diameter. Read More

    Nevi and lasers: Practical considerations.
    Lasers Surg Med 2018 Jan 21;50(1):7-9. Epub 2017 Nov 21.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Lasers are increasingly used for elective ablation of melanocytic nevi (MN). However, the associated risks of treating MN with lasers are debated and not well studied. Theoretical risks include inadvertently treating a melanoma mistaken for a nevus, the inability to remove all nevus cells and the possibility for residual cells to undergo malignant transformation, and the difficulty in clinically monitoring the remnant nevus for melanoma progression. Read More

    Gastric and Rectal Metastases from Malignant Melanoma Presenting with Hypochromic Anemia and Treated with Immunotherapy.
    Case Rep Oncol Med 2017 12;2017:2079068. Epub 2017 Oct 12.
    Medical Oncology Unit, Dipartimento di Scienze Chirurgiche, Oncologiche e Stomatologiche, University of Palermo, Palermo, Italy.
    The authors present a case of an 80-year-old Caucasian male with multiple gastric and rectal metastases from malignant melanoma presenting with hypochromic anemia as the sole symptom of disease without evidence of cutaneous and ocular tumor localization. The patient had a medical history positive for malignant lentigo melanoma of the occipital region of the scalp and early stage laryngeal squamous cell carcinoma and prostatic carcinoma treated with radiation therapy. The authors make some considerations on intestinal involvement by metastatic melanoma and discuss the choice of not treating with endoscopic procedures the gastric metastatic lesions most likely responsible for the clinical sign present at diagnosis. Read More

    Melanoma in patients with GATA2 deficiency.
    Pigment Cell Melanoma Res 2018 Mar 10;31(2):337-340. Epub 2017 Dec 10.
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    GATA2 deficiency is a recently described genetic disorder affecting hematopoietic stem cells and is associated with immunodeficiency, hematologic malignancy, and various cutaneous pathologies including cutaneous tumors. To explore the incidence and clinical course of melanoma in patients with germline GATA2 deficiencies, we conducted a retrospective chart review of 71 such patients and identified two with invasive melanoma. One melanoma was diagnosed early because it was associated with pruritus due to a graft-versus-tumor effect following bone marrow transplantation. Read More

    Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy.
    Sci Rep 2017 Nov 16;7(1):15750. Epub 2017 Nov 16.
    Experimental Dermatology Group, Institute of Medical Biology, A*STAR, 8- Biomedical Grove, Singapore, Singapore.
    A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM). Read More

    Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
    BMC Med Genet 2017 11 15;18(1):130. Epub 2017 Nov 15.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd, Shanghai, 200433, China.
    Background: Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer.

    Case Presentation: We reported an isolated PJS patient who died of colon cancer, whose blood sample was collected together with all the available family members'. The entire coding region of the STK11 gene was amplified by PCR and analyzed by Sanger sequencing, through which, a novel mutation, c. Read More

    Multiple primary melanoma: a single centre retrospective review.
    Melanoma Res 2017 Dec;27(6):638-640
    Department of Dermatology, St James' Hospital, Dublin, Republic of Ireland.
    Prognosis has been shown to be worse for patients with multiple primary melanomas than those with a single melanoma. One recent retrospective study showed that older, white men were at higher risk of multiple primary melanomas. In our institution 2057 melanomas were diagnosed between January 1994 and March 2016. Read More

    Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma.
    JAMA Dermatol 2017 Dec;153(12):1278-1284
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Importance: The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins.

    Objectives: To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins. Read More

    A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
    Dig Dis Sci 2017 11 6;62(11):3014-3020. Epub 2017 Oct 6.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
    Background And Aims: Peutz-Jeghers syndrome (PJS) is an autosomal-dominant genetic disease caused by mutations in the tumor suppressor gene, STK11, which is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing both gastrointestinal and extraintestinal malignancies.

    Methods And Results: We treated a PJS patient without a positive family history, who possessed typical clinical manifestations including polyp canceration. In order to explore the genotype of this patient, blood samples were collected from all the available family members. Read More

    Synchronous conjunctival melanoma and lentigo maligna melanoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):565-567
    Division of Dermatopathology in the Anatomical Pathology Service at Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Lentigo maligna has an extensive and neoplastic character. It typically progresses slowly and may eventually develop into an invasive melanoma, which is called lentigo maligna melanoma. Ocular melanoma is the second most common type of melanoma. Read More

    Recurrence Rate of Melanoma in Situ when Treated with Serial Disk Staged Excision: A Case Series.
    J Clin Investig Dermatol 2017 Feb 27;5(1). Epub 2017 Feb 27.
    Department of Dermatology, Dermatologic and Mohs Micrographic Surgery Center, San Diego School of Medicine, University of California.
    Background: Cutaneous melanoma is one of the fastest rising cancer diagnoses in recent years. Melanoma in situ (MIS) constitutes a large proportion of all diagnosed melanomas. While surgical excision is considered the standard of therapy, the literature is not clear on which surgical technique minimizes local recurrence. Read More

    Recent development of signaling pathways inhibitors of melanogenesis.
    Cell Signal 2017 Dec 12;40:99-115. Epub 2017 Sep 12.
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National, University, Daejeon 34134, Republic of Korea.
    Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation. Read More

    Characterization of Surgical Procedures in the Spanish Mohs Surgery Registry (REGESMOHS) for 2013-2015.
    Actas Dermosifiliogr 2017 Nov 9;108(9):836-843. Epub 2017 Aug 9.
    Unidad de Investigación, Fundación Piel Sana, Academia Española de Dermatología, Madrid, España.
    Introduction: The Spanish Mohs Surgery Registry is used to collect data on the use and outcomes of Mohs micrographic surgery (MMS) in Spain. The aim of this study was to describe perioperative and intraoperative data recorded for MMS procedures performed between July 2013 (when the registry started) and January 2016.

    Material And Methods: Prospective cohort study of data from 18 hospitals. Read More

    Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):458-461. Epub 2017 Jul 19.
    Department of Anesthesiology & Intensive Care Medicine, Emergency Medicine & Pain Management, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067, Dresden, Germany.
    Background: Lentigo malignant melanoma is a melanoma subtype of chronic sun-damaged skin in elderly Caucasians. Amelanotic variants of lentigo malignant are extremely rare.

    Case Presentation: This is a case report of an 80-year-old male patient who presented with a non-pigmented exophytic tumour of his bald head. Read More

    SpectraCam: A new polarized hyperspectral imaging system for repeatable and reproducible in vivo skin quantification of melanin, total hemoglobin, and oxygen saturation.
    Skin Res Technol 2018 Feb 2;24(1):99-107. Epub 2017 Aug 2.
    Laboratoires Clarins, Pontoise, France.
    Background: An accurate way to determine skin pigmentation is to acquire the spectral reflectance of a skin sample and to quantify chromophores by reverse calculation from physical models of light propagation. Therefore, we tested a new hyperspectral imaging device and software suite, the SpectraCamsystem, and evaluated its accuracy to quantify skin chromophores.

    Methods: Validation of the SpectraCamsystem was performed by, firstly, comparing the known and the acquired reflectance spectra of color phantoms. Read More

    Seven Non-melanoma Features to Rule Out Facial Melanoma.
    Acta Derm Venereol 2017 Nov;97(10):1219-1224
    Department of Dermatology, Medical University of Vienna, Wien, Austria.
    Facial melanoma is difficult to diagnose and dermatoscopic features are often subtle. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value. In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas. Read More

    Beneficial Effect of Low Fluence 1,064 nm Q-Switched Neodymium:Yttrium-Aluminum-Garnet Laser in the Treatment of Senile Lentigo.
    Ann Dermatol 2017 Aug 21;29(4):427-432. Epub 2017 Jun 21.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo.

    Objective: To investigate the beneficial effect of low fluence 1,064 nm QS Nd:YAG laser in the treatment of senile lentigo on the face. Read More

    Melanoma subtypes demonstrate distinct PD-L1 expression profiles.
    Lab Invest 2017 Sep 24;97(9):1063-1071. Epub 2017 Jul 24.
    Department of Dermatology, Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy, and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
    PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic and predictive biomarker in patients with cutaneous melanoma, a finding closely related to its adaptive (IFN-γ-mediated) mechanism of expression. Approximately 35% of cutaneous melanomas express PD-L1, however, the expression patterns, levels, and prevalence in rarer melanoma subtypes are not well described. We performed immunohistochemistry for PD-L1 and CD8 on 200 formalin-fixed paraffin-embedded specimens from patients with acral (n=16), mucosal (n=36), uveal (n=103), and chronic sun-damaged (CSD) (n=45) melanomas (24 lentigo maligna, 13 'mixed' desmoplastic, and 8 'pure' desmoplastic melanomas). Read More

    Patients' Characteristics, Histopathological Findings, and Tumor Stage in Different Types of Malignant Melanoma: A Retrospective Multicenter Study.
    Acta Med Iran 2017 May;55(5):316-323
    Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AND Universal Scientific Education and Research Network (USERN), Tehran, Iran.
    Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histopathological findings. Read More

    Dermoscopy of Pigmented Actinic Keratosis of the Face: A Study of 232 Cases.
    Actas Dermosifiliogr 2017 Nov 11;108(9):844-851. Epub 2017 Jul 11.
    Department of Dermatology, University Hospital Hassan II, Fez, Morocco.
    The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna.

    Objective: To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients.

    Methods: Descriptive and analytical study of 232 PAK. Read More

    Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour.
    J Cutan Med Surg 2018 Jan/Feb;22(1):51-57. Epub 2017 Jul 7.
    1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
    Amelanotic lentigo maligna melanoma represents <2% of melanomas. Diagnosis is delayed owing to the lack of lesion pigmentation and advanced disease at presentation. Excision with appropriate margins is the treatment standard, but the starting point for such margins is often unclear. Read More

    Anatomic mapping and clinicopathologic analysis of benign acral melanocytic neoplasms: A comparison between adults and children.
    J Am Acad Dermatol 2017 Oct 1;77(4):735-745. Epub 2017 Jul 1.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. Electronic address:
    Background: The clinicopathologic features of benign acral melanocytic neoplasms (BAMNs) remain poorly understood.

    Objective: To define the clinicopathologic features of BAMNs.

    Methods: We analyzed clinical data and mapped BAMNs anatomically. Read More

    Acute exacerbation of myasthenia gravis with topical imiquimod use.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):333
    Texas A&M College of Medicine Health Science Center (Saad, Mansouri, Housewright) and the Department of Dermatology, Scott and White Hospital (Mansouri, Housewright), Temple, Texas.
    Imiquimod activates the immune system when applied to a local area. We report a patient with a history of well-controlled myasthenia gravis who was prescribed imiquimod for lentigo maligna. Treatment was halted after 2 weeks when the patient reported itching and irritating sensations in his throat, consistent with previous myasthenia exacerbations. Read More

    Sporadic Case of Peutz-Jeghers Polyp in a 14-Year Boy.
    J Coll Physicians Surg Pak 2016 Nov;26(11):S95-S96
    Department of Surgical I, Dow University of Health Sciences, Civil Hospital, Karachi.
    Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis of the gastrointestinal tract, with pigmentation around lips, the buccal mucosa, and anal area. Patients have a strong family history. Patients of PJS present with abdominal pain, blood in stools, and occasionally melena because of polyps, along with classical mucocutaneous pigmentation. Read More

    Cancer risk in patients with Peutz-Jeghers syndrome: A retrospective cohort study of 336 cases.
    Tumour Biol 2017 Jun;39(6):1010428317705131
    1 Department of Gastroenterology, Clinical College of Air Force General Hospital, Anhui Medical University, Beijing, China.
    Peutz-Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz-Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz-Jeghers syndrome in China were enrolled. Read More

    Handheld reflectance confocal microscopy to aid in the management of complex facial lentigo maligna.
    Cutis 2017 May;99(5):346-352
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, and Department of Dermatology, Weill Cornell Medical College, New York, USA.
    Diagnosis and management of lentigo maligna (LM) and LM melanoma (LMM) is challenging. Novel noninvasive imaging technologies such as reflectance confocal microscopy (RCM) have advanced the ability to better diagnose and monitor challenging lesions. In addition, the new handheld RCM (HRCM) together with the use of videomosaics has allowed an accurate evaluation of large lesions in concave/convex areas of the body (eg, the face). Read More

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