Cell Signal 2017 Dec 12;40:99-115. Epub 2017 Sep 12.
College of Pharmacy and Institute of Drug Research and Development, Chungnam National, University, Daejeon 34134, Republic of Korea.
Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation. Read More