4,409 results match your criteria Lentigo


Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: Evaluation of a series of 41 cases.

Australas J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology Service, Hospital Fundación de Alcorcón, Madrid, Spain.

Background/objectives: Lentigo maligna is usually located on the face. Extrafacial lentigo maligna is less common, and diagnosis of early forms is very difficult. Confocal microscopy of facial and extrafacial lentigo maligna shares the same features (abundant dendritic cells and generalised atypical junctional thickenings) and helps us to identify the dermoscopic features of extrafacial lentigo maligna. Read More

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http://dx.doi.org/10.1111/ajd.13051DOI Listing

A Collision Tumor: Reflectance Confocal Microscopy Features and Correlation between Dermoscopy and Histopathology.

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/155/254153
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http://dx.doi.org/10.4103/ijd.IJD_278_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440176PMC
April 2019
2 Reads

Einsatz des 2940 nm ER:YAG-Lasers zur Behandlung der Lentigo maligna.

J Dtsch Dermatol Ges 2019 04;17(4):425-432

Department of Dermatovenereology, Charles University, Faculty of Medicine and Teaching Hospital in Pilsen, Tschechien.

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http://dx.doi.org/10.1111/ddg.13814_gDOI Listing

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

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http://dx.doi.org/10.1159/000496539DOI Listing
April 2019
4 Reads

Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition.

Photochem Photobiol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, Dermatology Unit, University of Modena & Reggio Emilia, Modena, Italy.

In vivo reflectance confocal microscopy (RCM) is a noninvasive high-resolution skin imaging tool that has become an important adjunct to clinical exam, dermoscopy and histopathology assessment, in the diagnosis and management of pigmented macules of the face. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging and RCM improves the diagnostic accuracy in the differential diagnosis of LM with other macules of the face such as solar lentigo (SL), pigmented actinic keratosis (PAK), seborrheic keratosis (SK) and lichen planus-like keratosis (LPLK). Here we review the state-of-the-art of RCM morphologic descriptors, standardized terminology, and diagnostic algorithms for the RCM assessment of pigmented macules of the face including melanocytic, and nonmelanocytic lesions. Read More

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http://dx.doi.org/10.1039/c8pp00525gDOI Listing
April 2019
2 Reads

The use of 2940-nm ER:YAG laser for the treatment of lentigo maligna.

J Dtsch Dermatol Ges 2019 Apr 1;17(4):425-431. Epub 2019 Apr 1.

Department of Dermatovenereology, Charles University, Faculty of Medicine and Teaching Hospital in Pilsen, Czech Republic.

Objectives: Lentigo maligna is a common in situ malignancy in elderly patients, with a low risk of progression to an invasive tumor. Surgical treatment may be complicated or refused. Non-surgical treatment options (such as lasers) may therefore be needed. Read More

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http://dx.doi.org/10.1111/ddg.13814DOI Listing
April 2019
2 Reads

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma.

Cancer Med 2019 Apr 1. Epub 2019 Apr 1.

Prognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society, Kumamoto, Japan.

Background: The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported.

Objectives: To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors.

Methods: Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. Read More

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http://dx.doi.org/10.1002/cam4.2110DOI Listing
April 2019
2 Reads

Melanoma on Chronically Sun Damaged Skin: Lentigo Maligna and Desmoplastic Melanoma.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, University of Connecticut Health Center, Farmington, CT.

There are multiple, genetically distinct pathways that give rise to melanoma. Melanomas on sun damaged skin (MSDS) - including lentigo maligna (LM) and desmoplastic melanoma (DM) - have distinct genetic profiles and are uniquely linked to chronic ultraviolet (UV) exposure. In this article we discuss the etiologies of LM and DM, emerging diagnostic adjuncts that may be helpful in accurately identifying these lesions, and the clinical relevance of their frequent co-occurrence. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.066DOI Listing
March 2019
2 Reads

Surgical Management of Localized Melanoma: A National Cancer Database Retrospective Review.

Br J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Rutgers New Jersey Medical School, Newark, NJ, USA.

Mohs micrographic surgery (MMS) for melanoma remains controversial. Currently, no published clinical trials have examined the role of MMS versus wide local excision (WLE) for melanoma, despite the fact that the use of MMS for melanoma is increasing in the United States. The limited retrospective data that does exist demonstrates MMS as an equally effective modality for the management of melanoma in-situ, lentigo maligna melanoma, and cutaneous head and neck melanomas. Read More

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http://dx.doi.org/10.1111/bjd.17901DOI Listing
March 2019
1 Read

Is melanocyte density our last hope? Comparison of histologic features of photodamaged skin and melanoma in situ after staged surgical excision with concurrent scouting biopsies.

J Cutan Pathol 2019 Mar 23. Epub 2019 Mar 23.

Division of Dermatology, Department of Medicine, Loyola University Chicago Stritch School of Medicine.

How much is too much? How much is not enough? These questions frequently come to mind when performing and examining a staged excision for a malignant pigmented lesion. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/cup.13462DOI Listing

Inadequacy of Recommended Margins in the Treatment of Lentigo Maligna.

Skinmed 2019 19;17(1):40-42. Epub 2019 Mar 19.

Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ.

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March 2019
8 Reads

Immunohistochemical characterization of benign activation of junctional melanocytes and melanoma in-situ of the nail unit.

J Cutan Pathol 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology, Pathology and the Knight Cancer Institute, Oregon Health & Sciences University, Portland, OR, USA.

Background: Immunohistochemical stains that distinguish benign, pigmented nail lesions from malignancy are needed. Candidate markers of malignant transformation include p16, HMB45 and Ki-67, with p16 being of particular interest. There is limited knowledge about the spectrum of p16 expression in pigmented lesions, especially junctional melanocytic proliferations of the nail. Read More

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http://dx.doi.org/10.1111/cup.13457DOI Listing

The dermoscopic features of facial aging among Egyptians: A comparative study between males and females.

J Cosmet Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.

Background: Few studies have evaluated facial photoaging by dermoscopy. Only one study has been performed among Egyptians.

Objective: To study and compare the dermoscopic features of facial aging in males and females and to relate these features to clinical criteria. Read More

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http://dx.doi.org/10.1111/jocd.12913DOI Listing
March 2019
1 Read

Histologic predictors of invasion in partially biopsied lentigo maligna melanoma.

J Am Acad Dermatol 2019 Apr 26;80(4):1150-1152. Epub 2018 Oct 26.

Research Unit EA 4340 Biomarkers in Cancerology and in Hemato-oncology, University of Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, Boulogne-Billancourt, France; Department of Dermatology, Ambroise Paré Hospital, Boulogne-Billancourt, France.

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http://dx.doi.org/10.1016/j.jaad.2018.10.036DOI Listing

Low-fluenced erbium:yttrium-aluminium-garnet laser treatment in combination with broadband light pretreatment for various pigmentation disorders in Asian patients.

J Cosmet Dermatol 2019 Mar 1. Epub 2019 Mar 1.

Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.

Background: Low-fluenced 2940-nm erbium (Er):yttrium-aluminium-garnet (YAG) resurfacing elicits ablative photothermal tissue reactions confined to the uppermost parts of the epidermis.

Objective: To demonstrate the efficacy and safety of low-fluenced ablative Er:YAG laser treatment in combination with broadband light (BBL) pretreatment for various pigmentation disorders.

Methods: In total, 35 Korean patients with various pigmentation disorders were pretreated with BBL, and then, low-fluenced Er:YAG laser resurfacing was performed with a beam size of 4 mm and a fluence of 1. Read More

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http://dx.doi.org/10.1111/jocd.12897DOI Listing

Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines.

Dermatopathology (Basel) 2019 Jan-Mar;6(1):1-11. Epub 2019 Jan 3.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Introduction: Solar lentigines (SL) affect chronically UV-radiated skin. Treatment is often refractory. Deeper knowledge on its pathogenesis might improve therapeutic effects. Read More

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http://dx.doi.org/10.1159/000495404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381907PMC
January 2019

Braf-V600e immunohistochemical analyses in a series of 15, Caucasian patients affected by lentigo maligna.

Acta Histochem 2019 Apr 20;121(3):380-381. Epub 2019 Feb 20.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

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http://dx.doi.org/10.1016/j.acthis.2019.02.003DOI Listing

Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.

Arch Dermatol Res 2019 Apr 18;311(3):183-191. Epub 2019 Feb 18.

Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan.

Little is known about the anti-pigmenting effects of whitening agents on solar lentigos (SLs), which comprise ~ 60% of hyperpigmented facial lesions of Asian subjects. Lotions with or without 6% L-ascorbate-2-phosphate trisodium salt (APS) [test lotion (TL) and placebo lotion (PL), respectively] were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs on both sides of their faces. Pigmentation scores were evaluated using a photo-scale and the skin colors were assessed using a color difference meter and a mexameter for SLs and the non-lesional surrounding skin (NLS). Read More

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http://dx.doi.org/10.1007/s00403-019-01892-2DOI Listing
April 2019
1 Read

Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters.

Dermatol Pract Concept 2019 Jan 31;9(1):54-62. Epub 2019 Jan 31.

Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.

Background: mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as a therapeutic target in advanced melanoma, their prognostic value is still debated.

Objective: To assess mutation status in primary, recurrent, or metastatic MM and its correlations with histopathological findings. Read More

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http://dx.doi.org/10.5826/dpc.0901a13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368075PMC
January 2019
1 Read

Ten Years experience using the Johnson Square Procedure for Lentigo Maligna.

Br J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, NHS Treatment Centre, Nottingham, UK.

Lentigo maligna (LM) accounts for 4-15% of all melanomas with risk of progression to lentigo maligna melanoma (LMM) estimated to be as high as 20% or as low as 5%. Due to the size, location and sub-clinical spread of these lesions, margin control can be difficult. Clearance rates 24-70% have been reported when using standard excision with 5mm margins and bread-loaf histological processing Recurrence rates of 7-20%. Read More

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http://doi.wiley.com/10.1111/bjd.17774
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http://dx.doi.org/10.1111/bjd.17774DOI Listing
February 2019
5 Reads

[Nasal cavity mucosal melanoma with skin extension mimicking a malignant lentigo with mucosal extension].

Ann Chir Plast Esthet 2019 Feb 7. Epub 2019 Feb 7.

Service de chirurgie maxillofaciale, university hospital Estaing, CHU Clermont-Ferrand, 1, place Lucie Aubrac, 63003 Clermont-Ferrand cedex 1, France; UMR Inserm U1107, Neuro-Dol, Trigeminal Pain and Migraine, faculté de chirurgie dentaire, université d'Auvergne, 2, rue de Braga, 63100 Clermont-Ferrand, France. Electronic address:

Mucosal melanoma is a rare malignant disease developed from melanocyte. We report the case of a patient with nasal cavity mucosal melanoma with a primary clinical and histological diagnosis of malignant lentigo with mucosal spreading. The presence of a c-Kit mutation, in a second lecture and the evolving nature of the lesion, reorientated the diagnosis of malignant lentigo to mucosal melanoma with skin extension. Read More

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http://dx.doi.org/10.1016/j.anplas.2019.01.005DOI Listing
February 2019
1 Read

Spontaneous Hair Repigmentation in an 80-Year-Old Man: A Case of Melanoma-Associated Hair Repigmentation and Review of the Literature.

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Geisel School of Medicine at Dartmouth, Hanover, NH.

Spontaneous hair repigmentation of physiologically white or gray hair is a rare occurrence that may be associated with melanoma in elderly individuals. We present the first case of this phenomenon in a man. A gray-haired, 80-year-old man presented to dermatology clinic with a 3-cm lock of black hair on his vertex scalp that developed over 1 year. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001353DOI Listing
January 2019
12 Reads

Nine per cent of biopsy-proven lentigo maligna lesions are reclassified as lentigo maligna melanoma after surgery.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/bjd.17714DOI Listing
February 2019

Peutz-Jeghers Syndrome.

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

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http://dx.doi.org/10.1056/NEJMicm1806623DOI Listing
January 2019
1 Read

[Clinicopathological features of non-neoplastic colorectal polyps].

Authors:
L Jiang Y F Jiao

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):98-101

Department of Pathology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.

To characterize clinicopathological characteristics of the non-neoplastic colorectal polyps for accurate diagnosis. 1 190 cases were collected from the Second Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 and their clinicopathological characteristics were reviewed. There were 746 males and 444 females patients with male/female ratio of 1. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.004DOI Listing
February 2019
1 Read

Long-term outcomes of imiquimod-treated lentigo maligna.

Clin Exp Dermatol 2019 Jan 20. Epub 2019 Jan 20.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Background: Lentigo maligna (LM) may be disfiguring and can progress to LM melanoma. Surgical excision remains the mainstay of treatment, but may result in disfigurement when used for large facial lesions. Topical imiquimod is a nonsurgical alternative although data on its long-term efficacy remain limited. Read More

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http://doi.wiley.com/10.1111/ced.13896
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http://dx.doi.org/10.1111/ced.13896DOI Listing
January 2019
12 Reads

[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1323-1327

Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
 Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
 Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.007DOI Listing
December 2018
15 Reads

Cheek Cutaneous Melanomas: A Review of 98 Cases.

Ann Plast Surg 2019 Apr;82(4):407-410

From the Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

Background: Most head and neck melanomas occur on the face, with the cheek being the most frequently affected site. So far, small numbers of researches on cheek melanomas have yielded insufficient and controversial results. In this trial, we aimed to define the histopathological and clinical features specific to cheek melanomas and to compare them with other head and neck melanomas by using a large group of patients from a single tertiary center. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001695DOI Listing
April 2019
3 Reads

Teaching Benign Skin Lesions as a Strategy to Improve the Triage Amalgamated Dermoscopic Algorithm (TADA).

J Am Board Fam Med 2019 Jan-Feb;32(1):96-102

From Maine Medical Center, Division of Dermatology, Portland, ME (EVS); Department of Family & Community Medicine (HTA) and Department of Dermatology (AG, MB), Penn State Milton S. Hershey Medical Center, Hershey, PA; Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain (OY); Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY (OY, SWD, AAM).

Introduction: Dermoscopy aids family physicians (FPs) in skin cancer detection. The triage amalgamated dermoscopic algorithm (TADA) was created to simplify the dermoscopic evaluation of a skin growth. The purpose of this image-based study was to evaluate the effect of teaching the clinical and dermoscopic features of benign skin lesions on the diagnostic accuracy of skin cancer identification using TADA. Read More

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http://www.jabfm.org/lookup/doi/10.3122/jabfm.2019.01.180049
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http://dx.doi.org/10.3122/jabfm.2019.01.180049DOI Listing
February 2018
18 Reads

Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.

Surv Ophthalmol 2018 Dec 20. Epub 2018 Dec 20.

Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Cutaneous melanoma, a potentially lethal malignancy of the periocular skin, represents only a small proportion of the roughly 87,000 new cases of cutaneous melanoma diagnosed annually in the United States. Most of our understanding of melanoma of the eyelid skin is extrapolated from studies of cutaneous melanoma located elsewhere. Recent years have witnessed major breakthroughs in molecular biology and genomics of cutaneous melanoma, some of which have led to the development of targeted therapies. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.12.002DOI Listing
December 2018
7 Reads

Epidemiological profile of primary cutaneous melanoma over a 15-year period at a private skin cancer center in Colombia.

Rev Salud Publica (Bogota) 2018 Mar-Apr;20(2):226-231

AA: MD. Oncologist Dermatologist Universidad Nacional de Colombia, Universidad Javeriana. Instituto Nacional de Cancerología. Bogotá, Colombia.

Objective : To describe clinical, histopathological and treatment characteristics of melanoma in a private institution of Bogotá, Colombia, and to identify differences regarding sex and age.

Materials And Methods : Observational, retrospective study. 415 medical records between January 1999 and May 2014 were analyzed. Read More

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https://revistas.unal.edu.co/index.php/revsaludpublica/artic
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http://dx.doi.org/10.15446/rsap.V20n2.65616DOI Listing
June 2017
14 Reads

Peutz-Jeghers syndrome: need for early screening.

BMJ Case Rep 2018 Dec 13;11(1). Epub 2018 Dec 13.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Peutz-Jeghers syndrome (PJS) is an autosomal dominant cancer-predisposing condition characterised by intestinal hamartomatous polyps and distinct melanin depositions in skin and mucosa. Small intestinal cancer in patients with PJS usually presents by the third decade. A 7-year-old-PJS boy presented with recurrent episodes of colicky abdominal pain and melena requiring repeated blood transfusions. Read More

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http://dx.doi.org/10.1136/bcr-2018-225076DOI Listing
December 2018

Confocal Microscopy and Lentigo Maligna: An in vivo Pilot Study for the Assessment of Response to Imiquimod Therapy.

Dermatology 2019 14;235(2):150-155. Epub 2018 Dec 14.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: Reflectance confocal microscopy (RCM) is a noninvasive technique that provides real-time in vivo images of the epidermal layer. Imiquimod has been recommended as an alternative treatment in lentigo maligna (LM) when surgical excision is not the treatment of choice. In the present study we compare the results of in vivo RCM to the histopathological examination before and after treatment of LM with topical imiquimod. Read More

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http://dx.doi.org/10.1159/000495034DOI Listing
December 2018
1 Read

Evaluation of the Novel Synthetic Tyrosinase Inhibitor ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) and .

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

College of Pharmacy, Pusan National University, Busan 46241, Korea.

Tyrosinase is a key enzyme in melanin synthesis, catalyzing the initial rate-limiting steps of melanin synthesis. Abnormal and excessive melanin synthesis is the primary cause of serious skin disorders including melasma, senile lentigo, freckles, and age spots. In attempts to find potent and safe tyrosinase inhibitors, we designed and synthesized a novel compound, ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498), and evaluated its tyrosinase inhibitory activity and . Read More

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http://dx.doi.org/10.3390/molecules23123307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321646PMC
December 2018
3 Reads

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.

Int J Dermatol 2019 May 13;58(5):577-581. Epub 2018 Dec 13.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.

Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).

Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.

Results: Although for the global period LM/LMM represented only 8. Read More

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http://dx.doi.org/10.1111/ijd.14334DOI Listing
May 2019
14 Reads

[Melanonychia].

Ugeskr Laeger 2018 Dec;180(50)

Melanonychia is seen, when melanin is incorporated in the nail, which gives a band of dark discolouration of the nail. Nail discolouration is a common cause for patients to seek medical attention, and it is often benign. Melanonychia can be seen due to melanocytic proliferation (ungual naevi), benign hyperplasia (lentigo) and hypermelanosis (infections, traumas). Read More

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December 2018
3 Reads

Reflectance confocal microscopy terminology glossary for nonmelanocytic skin lesions: A systematic review.

J Am Acad Dermatol 2019 May 8;80(5):1414-1427.e3. Epub 2018 Dec 8.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

Background: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for nonmelanocytic lesions (NMLs).

Objective: To review published RCM terms for NMLs and identify likely synonymous terms.

Methods: We conducted a systematic review of original research articles published up to August 19, 2017, adhering to Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.007DOI Listing
May 2019
5 Reads

Treatment of benign pigmented lesions using a novel Dermal Cooling System.

Lasers Surg Med 2019 Jan 27;51(1):59-61. Epub 2018 Nov 27.

Department of Dermatology, University of California San Diego, La Jolla 92122, California.

Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Read More

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http://dx.doi.org/10.1002/lsm.23037DOI Listing
January 2019
4 Reads

A tiny facial pigmented macule: overcoming the diagnostic challenge.

Dermatol Pract Concept 2018 Oct 31;8(4):322-323. Epub 2018 Oct 31.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

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http://dx.doi.org/10.5826/dpc.0804a15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246060PMC
October 2018
4 Reads

Introduction to reflectance confocal microscopy and its use in clinical practice.

JAAD Case Rep 2018 Nov 10;4(10):1014-1023. Epub 2018 Nov 10.

Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.

Reflectance confocal microscopy (RCM) is a novel technology that provides noninvasive, in vivo imaging of the skin at nearly histologic resolution. In 2016, the US Centers for Medicare and Medicaid Services (CMS) established reimbursement codes for RCM image acquisition and for the reading and interpretation of images. The combination of RCM imaging with dermoscopy has improved the accuracy of skin cancer diagnosis while reducing the number of biopsies of benign skin lesions. Read More

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http://dx.doi.org/10.1016/j.jdcr.2018.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232695PMC
November 2018
13 Reads

Gender differences, UV exposure and risk of lentigo maligna in a nationwide healthcare population cohort study.

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA.

Background: Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence.

Objective: To examine the association of UV light with LM by gender remains unclear. Read More

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http://doi.wiley.com/10.1111/jdv.15348
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http://dx.doi.org/10.1111/jdv.15348DOI Listing
November 2018
13 Reads

Possible hints and pitfalls in diagnosing Peutz-Jeghers syndrome.

J Pediatr Endocrinol Metab 2018 Dec;31(12):1381-1386

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Background Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal polyposis, mucocutaneous pigmentation and cancer predisposition. Patients with PJS can develop large calcifying Sertoli cell tumors (LCSTs). Case presentation A patient presented at 3 years of age with delayed development, hypermobility and later also with tall stature and advanced bone age. Read More

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http://www.degruyter.com/view/j/jpem.ahead-of-print/jpem-201
Publisher Site
http://dx.doi.org/10.1515/jpem-2018-0265DOI Listing
December 2018
18 Reads

Versatility of cervicofacial flaps: Cervical-medial cheek flap for reconstruction in cutaneous substance loss of the inner cheek.

Head Neck 2018 Dec 17;40(12):2574-2582. Epub 2018 Nov 17.

Department of Head and Neck Surgery, Centre Antoine Lacassagne, Nice, France.

Background: Preservation of facial harmony is a major challenge in reconstruction after resection of head and neck skin tumors. For large medial cheek-skin defects, we used a derived posterior-based cervicofacial flap, or cervical-medial cheek flap (CMCF).

Methods: We present a retrospective review of cases treated at a university-based cancer center. Read More

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http://doi.wiley.com/10.1002/hed.25183
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http://dx.doi.org/10.1002/hed.25183DOI Listing
December 2018
14 Reads

Management of Early-Stage Melanoma.

Facial Plast Surg Clin North Am 2019 Feb;27(1):35-42

Department of Dermatology, University of Michigan Medical School, University of Michigan, 1500 East Medical Center Drive, UH South Room F7680, Ann Arbor, MI 48109-5218, USA. Electronic address:

Melanoma is a potentially aggressive skin cancer with a steadily rising incidence. Most melanomas are diagnosed at an early stage and associated with an excellent prognosis when treated appropriately. Primary treatment for melanoma is surgical. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647406183006
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http://dx.doi.org/10.1016/j.fsc.2018.08.003DOI Listing
February 2019
41 Reads

Guidelines of care for the management of primary cutaneous melanoma.

J Am Acad Dermatol 2019 01 1;80(1):208-250. Epub 2018 Nov 1.

American Academy of Dermatology, Rosemont, Illinois.

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183258
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http://dx.doi.org/10.1016/j.jaad.2018.08.055DOI Listing
January 2019
19 Reads

Underwater endoscopic mucosal resection of a large jejunal polyp by single-balloon enteroscopy in a patient with Peutz-Jeghers syndrome.

Dig Liver Dis 2019 01 20;51(1):170-172. Epub 2018 Aug 20.

University Division of Gastroenterology, Department of Medical Sciences, University of Turin, City of Health and Science, Turin, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183089
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http://dx.doi.org/10.1016/j.dld.2018.08.017DOI Listing
January 2019
9 Reads

[Lentigo maligna and lentigo maligna melanoma: a clinicopathologic analysis of twenty-four cases].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):769-774

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.007DOI Listing
October 2018
17 Reads

[Spontaneous numbness along with pre-existing deviations in the pigmentation of the lower lip].

Ned Tijdschr Tandheelkd 2018 Oct;125(10):517-523

A 48-year-old man was referred for an evaluation of deviations in the pigmentation of the lower lip, intra-oral swelling and persistent numbness of the sensory area of the left mental nerve. In 2011, the diagnosis lentigo maligna of the lower lip was missed by histopathology of a biopsy performed elsewhere. In 2016, the numbness of the lower lip and chin was diagnosed by a neurologist as numb chin of unknown cause. Read More

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https://www.ntvt.nl/artikel/125/10/een-spontaan-dove-lip-met
Publisher Site
http://dx.doi.org/10.5177/ntvt.2018.10.18142DOI Listing
October 2018
11 Reads

The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management.

Australas J Dermatol 2018 Oct 9. Epub 2018 Oct 9.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.

Background/objectives: There are limited population-based data documenting the incidence and management of lentigo maligna (LM) and invasive lentigo maligna melanoma (LMM). We report the data on occurrence and management of LM and LMM in an Australian population.

Methods: Prospective collection of incidence and clinician-reported management of melanoma in situ (MIS; n = 450, capped) and localised invasive melanoma (n = 3251) notified to the New South Wales Cancer Registry over 12-months in 2006-2007. Read More

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http://doi.wiley.com/10.1111/ajd.12928
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http://dx.doi.org/10.1111/ajd.12928DOI Listing
October 2018
24 Reads