4,350 results match your criteria Lentigo
Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.
Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.
Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).
Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.
Results: Although for the global period LM/LMM represented only 8. Read More
Ugeskr Laeger 2018 Dec;180(50)
Melanonychia is seen, when melanin is incorporated in the nail, which gives a band of dark discolouration of the nail. Nail discolouration is a common cause for patients to seek medical attention, and it is often benign. Melanonychia can be seen due to melanocytic proliferation (ungual naevi), benign hyperplasia (lentigo) and hypermelanosis (infections, traumas). Read More
J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:
Background: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for non-melanocytic lesions (NMLs).
Objective: To review published RCM terms for NMLs and identify likely-synonymous terms.
Methods: Systematic review of original research articles adhering to PRISMA guidelines was conducted until August 19, 2017. Read More
Lasers Surg Med 2018 Nov 27. Epub 2018 Nov 27.
Department of Dermatology, University of California San Diego, La Jolla 92122, California.
Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Read More
Dermatol Pract Concept 2018 Oct 31;8(4):322-323. Epub 2018 Oct 31.
First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
JAAD Case Rep 2018 Nov 10;4(10):1014-1023. Epub 2018 Nov 10.
Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.
Reflectance confocal microscopy (RCM) is a novel technology that provides noninvasive, in vivo imaging of the skin at nearly histologic resolution. In 2016, the US Centers for Medicare and Medicaid Services (CMS) established reimbursement codes for RCM image acquisition and for the reading and interpretation of images. The combination of RCM imaging with dermoscopy has improved the accuracy of skin cancer diagnosis while reducing the number of biopsies of benign skin lesions. Read More
J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Background: Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence.
Objective: To examine the association of UV light with LM by gender remains unclear. Read More
Head Neck 2018 Nov 17. Epub 2018 Nov 17.
Department of Head and Neck Surgery, Centre Antoine Lacassagne, Nice, France.
Background: Preservation of facial harmony is a major challenge in reconstruction after resection of head and neck skin tumors. For large medial cheek-skin defects, we used a derived posterior-based cervicofacial flap, or cervical-medial cheek flap (CMCF).
Methods: We present a retrospective review of cases treated at a university-based cancer center. Read More
Facial Plast Surg Clin North Am 2019 Feb;27(1):35-42
Department of Dermatology, University of Michigan Medical School, University of Michigan, 1500 East Medical Center Drive, UH South Room F7680, Ann Arbor, MI 48109-5218, USA. Electronic address:
Melanoma is a potentially aggressive skin cancer with a steadily rising incidence. Most melanomas are diagnosed at an early stage and associated with an excellent prognosis when treated appropriately. Primary treatment for melanoma is surgical. Read More
J Am Acad Dermatol 2018 Oct 29. Epub 2018 Oct 29.
American Academy of Dermatology, Rosemont, Illinois.
The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More
Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):769-774
Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Read More
Ned Tijdschr Tandheelkd 2018 Oct;125(10):517-523
A 48-year-old man was referred for an evaluation of deviations in the pigmentation of the lower lip, intra-oral swelling and persistent numbness of the sensory area of the left mental nerve. In 2011, the diagnosis lentigo maligna of the lower lip was missed by histopathology of a biopsy performed elsewhere. In 2016, the numbness of the lower lip and chin was diagnosed by a neurologist as numb chin of unknown cause. Read More
Australas J Dermatol 2018 Oct 9. Epub 2018 Oct 9.
Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
Background/objectives: There are limited population-based data documenting the incidence and management of lentigo maligna (LM) and invasive lentigo maligna melanoma (LMM). We report the data on occurrence and management of LM and LMM in an Australian population.
Methods: Prospective collection of incidence and clinician-reported management of melanoma in situ (MIS; n = 450, capped) and localised invasive melanoma (n = 3251) notified to the New South Wales Cancer Registry over 12-months in 2006-2007. Read More
Dermatol Ther 2018 Oct 4:e12757. Epub 2018 Oct 4.
Unit of Dermatology, IRCCS University Vita-Salute San Raffaele, Milan, Italy.
Theranostics 2018 9;8(17):4620-4632. Epub 2018 Sep 9.
Department of Dermatology, Ajou University School of Medicine, Suwon, 443-721, Korea.
Cutaneous ageing is an important extrinsic process that modifies the pigmentary system. Because cellular senescence is a fundamental ageing mechanism, we examined the role of senescent cells in ageing pigmentation. Biopsies obtained from senile lentigo and perilesional normal skin were assayed for a marker of cellular senescence, p16. Read More
J Am Acad Dermatol 2018 Sep 26. Epub 2018 Sep 26.
Memorial Sloan Kettering Cancer Center, New York, NY.
Background: Follicular involvement of lentigo maligna (LM) is considered a histopathologic hallmark, but its prevalence and characteristics have not been well-defined. The depth of intrafollicular extension by neoplastic melanocytes may have clinical importance in the treatment of lentigo maligna.
Objective: To describe the prevalence and features of follicular involvement in LM, including depth of follicular growth by melanocytes. Read More
Clin Exp Dermatol 2018 Sep 27. Epub 2018 Sep 27.
Skin Cancer Center Ruhr-University, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.
Recurrence rates of both lentigo maligna (LM) and lentigo maligna melanoma (LMM) following conventional surgery are usually relatively high. We aimed to assess the frequencies of melanocytes in tumour-free margins around LM/LMM using soluble adenylyl cyclase (sAC) immunohistochemistry, and to compare these with those of matched healthy contralateral skin. Using the primary mouse-anti-human sAC antibody R21, we evaluated pan-nuclear melanocytic R21 immunostaining, and found that it was significantly (P < 0. Read More
Dermatol Online J 2018 Sep 15;24(7). Epub 2018 Sep 15.
Department of Dermatology, University of Minnesota, Minneapolis, Minnesota Department of Dermatology, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota Department of Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota.
A 66-year-old man presented with a grayish 1mm macule on the left cheek. Dermatoscopic examination revealed annular-granular structures partially surrounding a single follicular ostium. Histopathologic examination demonstrated atypical, confluent single melanocytes at the basal layer with nesting, crowding, and upward migration descending along the hair follicle, consistent with the diagnosis of lentigo maligna (LM). Read More
G Ital Dermatol Venereol 2018 Sep 24. Epub 2018 Sep 24.
Dermatology Unit, University of Campania, Naples, Italy -
J Am Acad Dermatol 2018 Oct;79(4):645-651.e4
Victorian Melanoma Service, Alfred Health, Melbourne, Australia.
Background: The recognition and diagnosis of clinically amelanotic or hypomelanotic melanoma is a challenge.
Objective: This study aimed to examine the anatomic distribution and risk factors associated with clinically amelanotic or hypomelanotic melanoma and compare the survival of patients with clinically amelanotic or hypomelanotic melanoma with that of patients with pigmented melanoma.
Methods: A prospective cohort study of all cases of primary invasive melanoma managed at a tertiary referral center was performed. Read More
Clin Case Rep 2018 Sep 9;6(9):1868-1870. Epub 2018 Aug 9.
FB Dermatology/Kleresca® Borupvang 5C, 2750 Ballerup Denmark.
Treating solar lentigines using picosecond-switched lasers that selectively remove the excess pigment was combined with Kleresca biophotonic treatment. This therapy uses fluorescent light energy to stimulate healing by increasing collagen production and reducing inflammation. Combining these therapies successfully removed solar lentigines and achieved normalized and rejuvenated treated skin. Read More
J Clin Aesthet Dermatol 2018 Aug 1;11(8):21-28. Epub 2018 Aug 1.
Drs. Soleymani, Lanoue, and Rahman are with the Department of Dermatology at Stanford University School of Medicine in Redwood City, California.
Chemoexfoliation, also known as chemical peeling, is a method of targeted cutaneous ablation using specific caustic agents that allow for rapid, predictable, and uniform thickness of chemoablation to a desired cutaneous depth, ultimately resulting in an improved appearance of skin. In this review, we provide an up-to-date analysis of all currently available chemical peels for dermatologic use, as well as a step-by-step instructional protocol for an algorithmic approach to treatment. A comprehensive search of the Cochrane Library, MEDLINE, and PUBMED databases was performed to identify relevant literature investigating chemical peeling agents. Read More
J Dermatol 2018 Nov 11;45(11):1337-1339. Epub 2018 Sep 11.
Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised mainly white populations, in which superficial spreading melanoma (SSM) and lentigo maligna melanoma are the major clinical types of melanoma. In contrast, Asians manifest a distinct clinicopathological type of melanoma from that of whites and show much higher frequencies of acral lentiginous melanoma (ALM) and mucosal melanoma, which have been shown to be less susceptible to immune checkpoint inhibitors. Because no comparative studies have been published showing improvement of OS by immune checkpoint inhibitors in Asian melanoma patients, we retrospectively collected the data for 45 melanoma patients treated with checkpoint inhibitors and 24 melanoma patients treated with chemotherapy alone before immune checkpoint inhibitors became available, and compared their OS. Read More
ANZ J Surg 2018 Sep 11. Epub 2018 Sep 11.
Plastic Surgery, St Vincent's Hospital, Melbourne, Victoria, Australia.
Dermatopathology (Basel) 2018 Jul-Sep;5(3):98-107. Epub 2018 Jul 24.
Department of Dermatology, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Melanocytic lesions of the nail unit are traditionally classified as follows: melanocytic activation, lentigo, nevi, and melanoma. Undoubtedly, melanoma is the most important malignant tumor of the nail unit. Differentiating nail unit melanoma from other melanocytic lesions is often difficult both clinically and histopathologically. Read More
Int J Dermatol 2019 Jan 31;58(1):75-79. Epub 2018 Aug 31.
Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.
Background: Melanomas arising from eyelid skin are exceptionally rare, accounting for <1% of eyelid malignancies and all cutaneous melanomas. The aim of this study was to identify the histopathological features and clinical behaviors of the palpebral skin melanoma patients from a single tertiary institution.
Patients And Methods: Seventeen Caucasian patients diagnosed with eyelid cutaneous melanoma were analyzed retrospectively. Read More
J Am Acad Dermatol 2018 Aug 28. Epub 2018 Aug 28.
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:
Background: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.
Objective: To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features.
Methods: All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Read More
Pigment Cell Melanoma Res 2018 Nov 30;31(6):725-727. Epub 2018 Aug 30.
Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
Dermatol Pract Concept 2018 Jul 31;8(3):198-203. Epub 2018 Jul 31.
Department of Dermatology and Venereology, Centro Hospitalar São João, EPE Porto, Portugal.
Recognition of facial lentigo maligna (LM) is often difficult, particularly at early stages. Algorithms and multivariate diagnostic models have recently been elaborated on the attempt to improve the diagnostic accuracy. We conducted a cross-sectional and retrospective study to evaluate dermatoscopic criteria aiding in diagnosis of flat pigmented facial lesions (FPFL). Read More
Dermatol Pract Concept 2018 Jul 31;8(3):188-190. Epub 2018 Jul 31.
Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
Dermatol Res Pract 2018 15;2018:7439807. Epub 2018 Jul 15.
Melanoma Institute Australia, Poche Centre, Crows Nest, Australia.
Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a histopathology report that records completion of excision. Some patients may not be surgical candidates due to comorbidities, patient preference, impact on function, and cosmesis or they have failed surgery with a positive margin. Read More
JMIR Res Protoc 2018 Aug 9;7(8):e170. Epub 2018 Aug 9.
Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Background: In the United Kingdom, 350,000 patients per year are referred to hospital clinics with suspicious moles, and approximately half undergo a biopsy to identify the 5%-10% who require further treatment. If cancer cannot be ruled out clinically and on the basis of biopsy results, the lesion is surgically removed. One type of precancerous mole, called lentigo maligna, is particularly challenging to delineate and treat. Read More
J Am Acad Dermatol 2018 Aug 6. Epub 2018 Aug 6.
Divisions of Dermatology, McGill University, Montréal, Canada. Electronic address:
Background: The incidence of cutaneous malignant melanoma (CMM) is on the rise in many parts of the world. However, there is limited knowledge on the epidemiology of CMM in Canada.
Objective: To conduct a comprehensive population-based study of CMM in Canada. Read More
Am J Dermatopathol 2018 Aug 6. Epub 2018 Aug 6.
Department of Pathology and Dermatopathology, Albany Medical College, Albany, NY.
Malignant melanoma (MM) may display highly variable phenotypic diversity, sometimes associated with loss of immunohistochemical melanocytic markers and acquisition of nonmelanocytic lineage of differentiation. Primary cutaneous MM with rhabdomyosarcomatous differentiation is extremely rare with only 5 reported cases in the literature. To date, a chronological progression of a MM to rhabdomyosarcoma has not been conclusively documented. Read More
Ann Dermatol 2018 Aug 28;30(4):454-457. Epub 2018 Jun 28.
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
A 69-year-old man presented with a black irregular patch on his left cheek. Skin biopsy revealed lentigo maligna melanoma . He was treated via partial excision of the melanoma, followed by the application of 5% imiquimod cream every other night for 6 to 8 hours. Read More
Acta Dermatovenerol Croat 2017 Dec;25(4):300-302
Dario Didona, MD, Prima Divisione Dermatologia Istituto Dermopatico dell'Immacolata, Via dei Monti di Creta 104, 00167 Rome , Italy;
Dear Editor, Reticulate pigmentary disorders (RPD) is a term used to classify a spectrum of several acquired and congenital disorders. Different clinical features can be present, including a reticular pattern and a freckle-like pattern with hyper- or hypo-pigmented macules (1). Dowling-Degos disease (DDD), an autosomal dominant genodermatosis, is the main type of RPD (2). Read More
Case Rep Pathol 2018 28;2018:9410465. Epub 2018 Jun 28.
Department of Pathology, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis, MO 63104, USA.
Cutaneous spindle cell malignancy is associated with a broad differential diagnosis, particularly in the absence of a known primary melanocytic lesion. We present an unusually challenging patient who presented with clinical symptoms involving cranial nerves VII and VIII and a parotid-region mass, which was S100-positive while lacking in melanocytic pigment and markers. Over a year after resection of the parotid mass, both a cutaneous primary lentigo maligna melanoma and a metastatic CP angle melanoma were diagnosed in the same patient, prompting reconsideration of the diagnosis in the original parotid-region mass. Read More
Science 2018 07;361(6400):406-411
Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.
Germline mutations in , which encodes the tumor suppressor liver kinase B1 (LKB1), promote Peutz-Jeghers syndrome (PJS), a cancer predisposition syndrome characterized by the development of gastrointestinal (GI) polyps. Here, we report that heterozygous deletion of in T cells (LT mice) is sufficient to promote GI polyposis. Polyps from LT mice, mice, and human PJS patients display hallmarks of chronic inflammation, marked by inflammatory immune-cell infiltration, signal transducer and activator of transcription 3 (STAT3) activation, and increased expression of inflammatory factors associated with cancer progression [interleukin 6 (IL-6), IL-11, and CXCL2]. Read More
JAMA Dermatol 2018 Sep;154(9):1092-1094
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Am J Surg Pathol 2018 Nov;42(11):1456-1465
Departments of Pathology.
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is known about PRAME protein expression in melanocytic tumors. In this study we examined the immunohistochemical expression of PRAME in 400 melanocytic tumors, including 155 primary and 100 metastatic melanomas, and 145 melanocytic nevi. Read More
Dermatol Ther 2018 09 20;31(5):e12657. Epub 2018 Jul 20.
Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.
Brimonidine gel, originally approved for the treatment of facial rosacea, causes direct vasoconstriction and possesses extensive utilization in dermatologic fields. A Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) laser is generally used to treat solar lentigo (SL), often leaving unwanted postinflammatory hyperpigmentation (PIH), especially in dark-skinned individuals. A 58-year-old man with Fitzpatrick skin type IV presented to remove solar lentigines from his face. Read More
Melanoma Res 2018 Jul 16. Epub 2018 Jul 16.
Institute for Social Medicine and Epidemiology.
Up-to-date melanoma relative survival (RS) estimates and trend analysis facilitate close monitoring of melanoma patients' prognosis. This study aimed to provide recent 5-year and 10-year RS from melanoma, stratified by prognostic factors, and identify latest survival trends. Data from 12 German cancer registries were analysed. Read More
JAAD Case Rep 2018 Jul 12;4(6):568-572. Epub 2018 Jun 12.
Dermatologic Clinic, ASST Spedali Civili of Brescia, Brescia, Italy.
J Surg Oncol 2018 Jul 24;118(1):144-149. Epub 2018 Jun 24.
Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Background: No consensus exists regarding the best surgical strategy to achieve clear surgical margins while minimizing tissue excision when definitely excising lentigo maligna melanoma in situ (LM). The staged margin controlled excision (SMEX) technique is a modification of the spaghetti technique that allows surgeons to minimize margins and ensure complete excision of LM.
Objectives: Our objectives were twofold: a) to evaluate the effectiveness of SMEX for treatment of LM and b) detail the SMEX technique. Read More
Am J Dermatopathol 2018 Dec;40(12):884-889
Department of Anatomic Pathology, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.
Background: Equivocal pigmented lesions of the head are usually biopsied to avoid inappropriate treatment. Clinical approach has evolved from simple visual examination to sophisticated techniques for selecting the biopsy sites.
Objective: This study aimed to retrospectively evaluate the efficiency of dermoscopy (DE) and reflectance confocal microscopy (RCM) in sampling a histopathologically representative focus of lentigo maligna/lentigo maligna melanoma. Read More
Dermatol Surg 2018 Dec;44(12):1615-1618
ENT Department, University Clinic Ulm, Ulm, Germany.
Australas J Dermatol 2018 Jun 22. Epub 2018 Jun 22.
South Perth Specialist Skin Cancer Centre, Perth, Western Australia, Australia.
Background/objectives: There is a paucity of Australian data on the use of Mohs micrographic surgery for treating melanoma in situ and lentigo maligna. We share an Australian centre's experience with the technique.
Methods: A total of 62 patients with 62 lesions of melanoma in situ and lentigo maligna referred for treatment between 2015 and 2017 comprised the study group. Read More
An Bras Dermatol 2018 Jun;93(3):373-376
Department of Pathology, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged.
Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Read More
Dig Liver Dis 2018 08 4;50(8):864-866. Epub 2018 Jun 4.
Department of Gastroenterology, Airforce General Hospital of PLA, Beijing, China. Electronic address:
Dermatology 2018 12;234(1-2):37-42. Epub 2018 Jun 12.
Centro de Dermatologia Epidermis, Instituto CUF, Porto, Portugal.
Introduction: Lentigo maligna (LM) is a rare form of in situ melanoma, frequently seen as a large patch in elderly patients. The aim of this study was to assess clinical and dermoscopic features of LM.
Material And Methods: A retrospective study of LM patients presenting to our center between July 2007 and July 2017 was performed. Read More