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    Diagnosis and management of lentigo maligna: an observational study comparing 2005 with 2014 data in one institution.
    Clin Exp Dermatol 2017 Feb 22. Epub 2017 Feb 22.
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
    The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. Read More

    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Differential morphological and functional features of fibroblasts explanted from Solar Lentigo.
    Br J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    UMR U978 INSERM, Bobigny Cedex, France.
    Upon ageing, chronic exposure to ultraviolet radiations and pollution induces benign hyper-pigmented lesions, such as Solar Lentigo maculae (SL) (1) . Well-defined histologically, SL is distinguishable from other hyper-pigmented diseases and can be classified relative to its evolution (2-4) . Differential gene-profiling analyses comparing SL and normal skin biopsies revealed that SL tissues are mainly composed of epidermal activated melanocytes as well as hypo-proliferating and hypo-differentiated keratinocytes with a background of chronic inflammation. Read More

    Chondrosarcomatous Differentiation in a Large Malignant Melanoma of the Scalp.
    Case Rep Med 2016 18;2016:1063569. Epub 2016 Dec 18.
    Castle Hill Hospital, East Yorkshire, UK.
    Background. Divergent differentiation in malignant melanoma is a rare phenomenon, which can lead to delayed diagnosis or misdiagnosis, impacting upon patient treatment and outcome, as well as the understanding of tumour behaviour. Case. Read More

    Dermatoscopy-guided therapy of pigmented basal cell carcinoma with imiquimod.
    An Bras Dermatol 2016 Nov-Dec;91(6):764-769
    San Cecilio University Hospital - Granada, Spain.
    Background:: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod.

    Objective:: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Jan 7. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland.
    Invasive lentigo maligna melanoma (LMM) and its in situ precursor lentigo maligna (LM) are the most common melanoma types on the head and neck areas (1) . Clinically unsuspected invasion is revealed histologically in 5-52% of LMs (2) . Thus, correct early diagnoses are crucial for determining accurate resection margins and the discussion of sentinel lymph node examination (3) . Read More

    A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures.
    J Eur Acad Dermatol Venereol 2016 Dec 17. Epub 2016 Dec 17.
    Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Read More

    Incidence trends and clinical-pathological characteristics of invasive cutaneous melanoma from 1980 to 2010 in the canton of Zurich, Switzerland.
    Melanoma Res 2016 Dec 6. Epub 2016 Dec 6.
    aDivision of Cancer Epidemiology and Prevention, Epidemiology, Biostatistics and Prevention Institute bCancer Registry Zurich and Zug cDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Read More

    Lifetime UV exposure and Lentigo Maligna Melanoma.
    Br J Dermatol 2016 Dec 7. Epub 2016 Dec 7.
    Department of Dermatology, Warren Alpert Medical School.
    Although ultraviolet light is considered a key factor in the etiology of malignant melanoma (MM), the relationship between sunlight and MM is complex. Intermittent exposure and sunburns are far more predictive of melanoma than chronic exposure, and melanoma can arise in non-sun exposed sites. Furthermore, retrospective studies have shown that outdoor workers exposed to sunlight chronically are not at higher risk of melanoma compared with indoor workers living at the same latitude. Read More

    Follicular Malignant Melanoma: A Rare Morphologic Variant of Melanoma. Report of a Case and Review of the Literature.
    Am J Dermatopathol 2016 Nov 29. Epub 2016 Nov 29.
    *Department of Dermatology, University of Illinois at Chicago, Chicago, IL;†Advanced Dermatology and Mohs Surgery, Batavia, IL; and‡Consolidated Pathology Consultants, Libertyville, IL.
    Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Read More

    Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma.
    Br J Cancer 2017 Jan 29;116(2):253-259. Epub 2016 Nov 29.
    Institute for Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
    Background: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme.

    Methods: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Data from 350 306 SCREEN participants, who had been screened negative for melanoma, were linked to data of the state cancer registry. Read More

    University Hospital Waterford: 5-year experience of cutaneous melanoma.
    Ir J Med Sci 2016 Nov 21. Epub 2016 Nov 21.
    Department of Breast and Endocrine Surgery, University Hospital Waterford, Waterford, Ireland.
    Introduction: The incidence of cutaneous melanoma (CM) continues to rise in Ireland. Despite significant advances in melanoma molecular therapy, surgery remains the mainstay of treatment for CM. The University Hospital Waterford (UHW) prospectively maintained CM registry was established in 2010. Read More

    Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
    Acta Derm Venereol 2016 Nov 10. Epub 2016 Nov 10.
    Department of Dermatology, Nantes University Hospital, INSERM, 892, FR-44000 Nantes, France.
    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. Read More

    Colonisation of basal cell carcinoma by lentigo maligna: a case report, review of the literature, and series follow-up.
    Eur J Dermatol 2016 Oct;26(5):465-469
    Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, CH-1011 Lausanne, Switzerland.
    Background: Melanocytic tumours which colonise basal cell carcinomas (BCC) may be considered as either lentigo maligna (LM) (in situ) or invasive melanomas.

    Objectives: To highlight the diagnostic approach and long-term prognosis of LM which colonises BCC.

    Materials And Methods: Using Satter et al. Read More

    Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey.
    J Dermatolog Treat 2016 Nov 15:1-5. Epub 2016 Nov 15.
    a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Purpose: To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.

    Materials And Methods: The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 patients were enrolled and reviewed for clinical features and factors associated with PIH. Read More

    Prospective, randomized, evaluator-blinded study of the long pulse 532-nm KTP laser alone or in combination with the long pulse 1064-nm Nd: YAG laser on facial rejuvenation in Asian skin.
    Lasers Surg Med 2016 Nov 8;48(9):844-851. Epub 2016 Sep 8.
    Aoyama Institute of Women's Medicine, Tokyo Women's Medical University, Tokyo 107-0061, Japan.
    Background And Objective: Hyperpigmentation is a common concern in Asian patients. Few published studies address overall skin rejuvenation in this group using long-pulse (LP) laser to target pigmentation and stimulate dermal remodeling. The LP KTP 532-nm laser (LP 532-nm) is used primarily to remove epidermal lesions, while the LP Nd: YAG 1064-nm laser (LP 1064-nm) is used to stimulate dermal remodeling in Asian patients with varying efficacy. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    Desmoplastic melanoma: a challenge for the oncologist.
    Future Oncol 2017 Feb 12;13(4):337-345. Epub 2016 Oct 12.
    Department of Diagnostic & Clinical Medicine & Public Health, Clinical Pathology Unit, University of Modena & Reggio Emilia, Modena, Italy.
    Aim: To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM).

    Materials & Methods: Analysis of all DM records from 1991 to 2015.

    Results: The most common location of DMs was the head and neck (69%); median age and follow-up were 60. Read More

    Effect of topical imiquimod as primary treatment for lentigo maligna - the LIMIT-1 study.
    Br J Dermatol 2016 Oct 6. Epub 2016 Oct 6.
    Cancer Research UK Clinical Trials Unit, University of Birmingham.
    Background: Topical imiquimod is sometimes used for lentigo maligna (LM) in-situ melanoma instead of surgery, but frequency of cure is uncertain. Pathological complete regression (pCR) is a logical surrogate marker for cure after imiquimod, although residual LM and atypical melanocytic hyperplasia may not be reliably distinguished. A trial comparing imiquimod versus surgery might be justified by a high imiquimod pCR rate. Read More

    Downregulation of melanogenesis: drug discovery and therapeutic options.
    Drug Discov Today 2017 Feb 28;22(2):282-298. Epub 2016 Sep 28.
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 34134, South Korea.
    Melanin, primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a process called melanogenesis. However, the abnormal accumulation of melanin causes dermatological problems such as café-au-lait macules ephelides (freckles), solar lentigo (age spots) and melasma, as well as cancer and vitiligo. Hence the regulation of melanogenesis is very important for treating hyperpigmentary disorders. Read More

    In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs Surgeons.
    Dermatol Clin 2016 Oct;34(4):497-504
    Melanoma Unit, Dermatology Department, Hospital Clinic and Institut d'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain.
    Confocal microscopy is a modern imaging device that has been extensively applied in skin oncology. More specifically, for tumor margin assessment, it has been used in two modalities: reflectance mode (in vivo on skin patient) and fluorescence mode (on freshly excised specimen). Although in vivo reflectance confocal microscopy is an add-on tool for lentigo maligna mapping, fluorescence confocal microscopy is far superior for basal cell carcinoma and squamous cell carcinoma margin assessment in the Mohs setting. Read More

    Lentigo Maligna, Macules of the Face, and Lesions on Sun-Damaged Skin: Confocal Makes the Difference.
    Dermatol Clin 2016 Oct;34(4):421-429
    Dermatology, Sydney Melanoma Diagnostic Centre (SMDC), Royal Prince Alfred Hospital, Melanoma Institute Australia, Central Clinical School, Sydney University, Missenden Road, Camperdown, New South Wales 2050, Australia. Electronic address:
    Distinguishing lentigo maligna (LM) and lentigo maligna melanoma (LMM) from background pigmented non-melanoma lesions is challenging. The field of solar damage can obscure clinical assessment, and diagnostic ambiguities are created due to the overlap of the clinical features of LM with other benign lesions. Moreover, margin assessment on histology is limited by the resemblance between melanocytic hyperplasia of actinically damaged skin and scattered atypical melanocytes of LM/LMM. Read More

    Dermatol Clin 2016 Oct;34(4):411-419
    Dermatology Unit, UniMore, via del Pozzo, 71, Modena 41121, Italy.
    Melanomas are a wide range of tumors that differ in their epidemiology, morphology, genetic profile, and biological behavior. They can be grouped as superficial spreading melanoma, lentigo maligna, and nodular melanoma. Reflectance confocal microscopy is useful for the evaluation of skin lesions that are dermoscopically doubtful by increasing diagnostic accuracy and specificity. Read More

    Cutaneous Melanoma in Asians.
    Chonnam Med J 2016 Sep 23;52(3):185-93. Epub 2016 Sep 23.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Read More

    Associations between childhood height and morphologically different variants of melanoma in adulthood.
    Eur J Cancer 2016 Nov 16;67:99-105. Epub 2016 Sep 16.
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:
    Aim Of The Study: Melanoma subtypes have different aetiological characteristics. Child height is positively associated with adult melanoma; however, a clarification of associations with specific melanoma variants is necessary for an improved understanding of risk factors underlying the histologic entities. This study investigated associations between childhood height and future development of cutaneous melanoma variants. Read More

    Phototherapy in cosmetic dermatology.
    Clin Dermatol 2016 Sep-Oct;34(5):623-7. Epub 2016 May 20.
    Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago, IL. Electronic address:
    Light therapy has been incorporated into the art of healing and cosmesis for thousands of years and currently has found utility in many areas of medicine. Various modalities of cosmetic phototherapy are detailed, as well as the indications and mechanism of action for each modality. These modalities can be used to treat many common cosmetic conditions, including acne vulgaris, solar lentigo, and melasma. Read More

    Molecular and histological characterization of age spots.
    Exp Dermatol 2016 Sep 13. Epub 2016 Sep 13.
    R&D Front End Innovation, Beiersdorf AG, Hamburg, Germany.
    Age spots, also called solar lentigines and lentigo senilis, are light brown to black pigmented lesions of various sizes that typically develop in chronically sun-exposed skin. It is well known that age spots are strongly related to chronic sun exposure and are associated with photodamage and an increased risk for skin cancer; however, the mechanisms underlying their development remain poorly understood. We used immunohistochemical analysis and microarray analysis to investigate the processes involved in their formation, focusing on specific markers associated with the functions and proliferation of melanocytes and keratinocytes. Read More

    Segmental neurofibromatosis and cancer: report of triple malignancy in a woman with mosaic Neurofibromatosis 1 and review of neoplasms in segmental neurofibromatosis.
    Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.
    Department of Dermatology, University of California San Diego, San Diego, California.
    BackgroundSegmental neurofibromatosis, referred to as mosaic neurofibromatosis 1, patients present with neurofibromas or café au lait macules or both in a unilateral segment of the body.PurposeA woman with segmental neurofibromatosis and triple cancer (renal cell carcinoma, mixed thyroid carcinoma, and lentigo maligna) is described and cancers observed in patients with segmental neurofibromatosis are reviewed.MethodsPubMed was used to search the following terms, separately and in combination: cancer, malignancy, mosaic, neoplasm, neurofibroma, neurofibromatosis, segment, segmental, tumor. Read More

    Reflectance Confocal Microscopy in Lentigo Maligna.
    Actas Dermosifiliogr 2016 Dec 7;107(10):830-835. Epub 2016 Sep 7.
    Hospital Universitario Fundación de Alcorcón, Madrid, España.
    Lentigo maligna is the most common type of facial melanoma. Diagnosis is complicated, however, as it shares clinical and dermoscopic characteristics with other cutaneous lesions of the face. Reflectance confocal microscopy is an imaging technique that permits the visualization of characteristic features of lentigo maligna. Read More

    Survival and Surgical Outcomes for Pediatric Head and Neck Melanoma.
    JAMA Otolaryngol Head Neck Surg 2017 Jan;143(1):34-40
    Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle.
    Importance: Melanoma in children is rare, accounting for approximately 2% of all pediatric malignant neoplasms. However, for the past 30 years, the incidence of melanoma in those younger than 20 years has been increasing. Location of the primary tumor has been shown to be an important prognostic factor, with melanomas of the scalp and neck conferring a worse prognosis than those originating at other sites. Read More

    Histopathological diagnosis of acral lentiginous melanoma in early stages.
    Ann Diagn Pathol 2017 Feb 20;26:64-69. Epub 2016 Aug 20.
    Department of Pathology, Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Kaiser Permanente, Los Angeles, CA 90027-5969.
    Acral lentiginous melanoma is a rare variant of melanoma that is associated with a relatively low survival rate. The latter is partly due to the advanced stage in which the tumor is usually diagnosed. The diagnostic delay is mainly due to difficulties in identifying the very early histopathological signs of acral melanoma. Read More

    Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross-sectional study.
    J Eur Acad Dermatol Venereol 2017 Feb 5;31(2):355-360. Epub 2016 Sep 5.
    Department of Dermatology, Peking University People's Hospital, Beijing, China.
    Background: Skin ageing especially senile lentigo directly affects self-esteem. For decades, senile lentigo has been associated with chronic exposure to solar radiation. However, a study conducted recently in Caucasian subjects suggested that exposure to air pollution was significantly correlated with extrinsic skin ageing, in particular senile lentigines. Read More

    Association Between Confocal Morphologic Classification and Clinical Phenotypes of Multiple Primary and Familial Melanomas.
    JAMA Dermatol 2016 Oct;152(10):1099-1105
    Hospital Clinic I Provincial de Barcelona, Universitat de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain4Centro de Investigación Biomédica en Red en Enfermedades Raras, Barcelona, Spain.
    Importance: The improved knowledge of clinical, morphologic, and epidemiologic heterogeneity of melanoma in the context of multiple primary and familial melanomas may improve prevention, diagnosis, and prognosis of melanoma.

    Objective: To characterize reflectance confocal microscopy (RCM) morphologic patterns of melanomas in multiple primary and familial melanomas.

    Design, Setting, And Participants: In this cross-sectional, retrospective study, patients in a hospital-based referral center were recruited from March 1, 2010, through August 31, 2013; data analysis was conducted from September 1, 2013, through May 31, 2014. Read More

    Racial differences in six major subtypes of melanoma: descriptive epidemiology.
    BMC Cancer 2016 Aug 30;16:691. Epub 2016 Aug 30.
    School of Statistics and The center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave., Beijing, 100872, China.
    Background: Melanoma accounts for the majority of skin cancer deaths. It has over thirty different subtypes. Different races have been observed to differ in multiple aspects of melanoma. Read More

    Syndromic Gastric Polyps: At the Crossroads of Genetic and Environmental Cancer Predisposition.
    Adv Exp Med Biol 2016;908:347-69
    Department of Pathology, The Johns Hopkins University School of Medicine, 401 N Broadway Weinberg 2242, Baltimore, MD, 21231, USA.
    Gastric polyps occur in 1-4 % of patients undergoing gastroscopy. Although most are sporadic, some gastric polyps are part of an underlying hereditary syndrome. Gastric polyps can be seen in each of the well-known gastrointestinal polyposis syndromes, but also in Lynch syndrome and in several rare not primarily gastrointestinal syndromes. Read More

    Lentigo maligna - anatomic location as a potential risk factor for recurrences after non-surgical treatment.
    J Eur Acad Dermatol Venereol 2016 Aug 24. Epub 2016 Aug 24.
    Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    Background: A higher incidence of lentigo maligna (LM) recurrences on the nose was previously observed in our cohort after non-surgical treatment.

    Objectives: To determine histological parameters that might be related to the previously observed higher incidence of LM recurrences on the nose after non-surgical treatment.

    Methods: We randomly selected 22 surgical specimens of LM on the nose and 22 on the cheek. Read More

    Cutaneous head and neck melanoma (CHNM): A population-based study of the prognostic impact of tumor location.
    J Am Acad Dermatol 2016 Nov 18;75(5):975-982.e2. Epub 2016 Aug 18.
    Oslo Center for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
    Background: Most studies of cutaneous head and neck melanomas (CHNM) have reported poorer survival in CHNM compared with other sites, especially on the scalp/neck.

    Objective: We sought to compare patient and tumor characteristics between CHNM and cutaneous trunk and extremity melanomas and between CHNM locations (face/ear vs scalp/neck, anterior vs posterior), and to study prognostic factors in patients with CHNM.

    Methods: We studied all CHNM (n = 1074) from 8120 cases of cutaneous melanomas diagnosed in Norway in 2008 to 2012. Read More

    An update on cutaneous melanoma in Turkey: evaluation of 19-year data in a single tertiary centre and review of the literature.
    J Eur Acad Dermatol Venereol 2017 Feb 13;31(2):236-240. Epub 2016 Aug 13.
    Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
    Background: Information on frequency of melanoma and its clinicopathological subtypes derived from dermatology clinics in Turkey is limited.

    Objective: As data about melanoma show clear differences due to geographic and ethnic distribution, we scrutinized the rich data of our dermatology centre in Istanbul.

    Methods: Consecutive patients diagnosed with melanoma in a tertiary dermatology clinic during the last 19 years were retrospectively investigated about the clinical presentation of the skin lesions during admission, frequency of subtypes and localization of the tumour. Read More

    Ingenol Mebutate for Lentigo Maligna: A Case Report.
    Dermatology 2016 11;232 Suppl 1:24-8. Epub 2016 Aug 11.
    Department of Dermatology, University Hospital Inselspital, University of Bern, Bern, Switzerland.
    Background: Lentigo maligna (LM) is a melanoma in situ on sun-damaged skin, with a strong predilection to the head and neck area of the elderly. Many therapeutic modalities have been proposed in the treatment of this pathology, including surgery, cryotherapy, radiotherapy and topical imiquimod. Up to date surgical excision remains the treatment of choice with the lowest recurrence rate. Read More

    Defining "intermittent UVR exposure".
    Photochem Photobiol Sci 2016 Sep 5;15(9):1176-82. Epub 2016 Aug 5.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Background: Cutaneous malignant melanoma (CMM) has been associated with "intermittent UVR exposure", which in previous studies has mainly been assessed by retrospective questionnaire data. Further, there is no uniform definition of the term "intermittent UVR exposure".

    Objectives: We aimed to define and quantify "intermittent UVR exposure" by an objective measure. Read More

    VivaScope® 1500 and 3000 systems for detecting and monitoring skin lesions: a systematic review and economic evaluation.
    Health Technol Assess 2016 Jul;20(58):1-260
    Background: Skin cancer is one of the most common cancers in the UK. The main risk factor is exposure to ultraviolet radiation from sunlight or the use of sunbeds. Patients with suspicious skin lesions are first examined with a dermoscope. Read More

    Hamartomatous polyps - a clinical and molecular genetic study.
    Dan Med J 2016 Aug;63(8)
    Hamartomatous polyps (HPs) in the gastrointestinal (GI) tract are rare compared to other types of GI polyps, yet they are the most common type of polyp in children. The symptoms are usually rectal bleeding, abdominal pain, obstipation, anaemia, and/or small bowel obstruction. The polyps are typically removed concurrently with endoscopy when located in the colon, rectum, or stomach, whereas polyps in the small bowel are removed during push-enteroscopy, device-assisted enteroscopy, or by surgery. Read More

    Giant rectal polyp prolapse in an adult patient with the Peutz-Jeghers syndrome.
    BMJ Case Rep 2016 Jul 21;2016. Epub 2016 Jul 21.
    Labortorio de Fisiologia DIgestiva y Motilidad, Instituto de Investigaciones Medico Biologicas, Veracruz, Mexico Instituto de Investigaciones Medico Biologicas, Veracruz, Mexico.
    Peutz-Jeghers Syndrome (PJS) is an autosomal dominant intestinal polyposis syndrome characterised by the presence of hamartomatous polyps and mucocutaneous pigmentation. Prolapse of the polyps through the anus is an infrequent manifestation in children with PJS, and this complication is extremely rare in adult patients. We report the case of a 30-year-old man recently diagnosed with PJS who was seen at the emergency department because of the abrupt onset of severe anal pain with a foreign body sensation in the anal canal and rectal bleeding. Read More

    Total earlobe reconstruction with a superiorly based preauricular flap.
    An Bras Dermatol 2016 May-Jun;91(3):372-4
    Hospital Garcia de Orta - Almada, Portugal.
    An 86-year-old woman was referred for treatment of a lentigo maligna melanoma on the left earlobe, confirmed by cutaneous biopsy. The resulting surgical defect involved the earlobe's full thickness. The authors outline a simple method for reconstructing the entire lobe in one stage, without grafts, whilst offering a pleasant appearance. Read More

    Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study.
    J Am Acad Dermatol 2016 Oct 16;75(4):698-705. Epub 2016 Jul 16.
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island.
    Background: The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features.

    Objective: We sought to determine trends in diagnosis and clinical features of MIS.

    Methods: Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Read More

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