4,377 results match your criteria Lentigo


Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.

Arch Dermatol Res 2019 Feb 18. Epub 2019 Feb 18.

Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan.

Little is known about the anti-pigmenting effects of whitening agents on solar lentigos (SLs), which comprise ~ 60% of hyperpigmented facial lesions of Asian subjects. Lotions with or without 6% L-ascorbate-2-phosphate trisodium salt (APS) [test lotion (TL) and placebo lotion (PL), respectively] were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs on both sides of their faces. Pigmentation scores were evaluated using a photo-scale and the skin colors were assessed using a color difference meter and a mexameter for SLs and the non-lesional surrounding skin (NLS). Read More

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http://dx.doi.org/10.1007/s00403-019-01892-2DOI Listing
February 2019

Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters.

Dermatol Pract Concept 2019 Jan 31;9(1):54-62. Epub 2019 Jan 31.

Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.

Background: mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as a therapeutic target in advanced melanoma, their prognostic value is still debated.

Objective: To assess mutation status in primary, recurrent, or metastatic MM and its correlations with histopathological findings. Read More

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http://dx.doi.org/10.5826/dpc.0901a13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368075PMC
January 2019

Ten Years experience using the Johnson Square Procedure for Lentigo Maligna.

Br J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, NHS Treatment Centre, Nottingham, UK.

Lentigo maligna (LM) accounts for 4-15% of all melanomas with risk of progression to lentigo maligna melanoma (LMM) estimated to be as high as 20% or as low as 5%. Due to the size, location and sub-clinical spread of these lesions, margin control can be difficult. Clearance rates 24-70% have been reported when using standard excision with 5mm margins and bread-loaf histological processing Recurrence rates of 7-20%. Read More

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http://doi.wiley.com/10.1111/bjd.17774
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http://dx.doi.org/10.1111/bjd.17774DOI Listing
February 2019
1 Read

[Nasal cavity mucosal melanoma with skin extension mimicking a malignant lentigo with mucosal extension].

Ann Chir Plast Esthet 2019 Feb 7. Epub 2019 Feb 7.

Service de chirurgie maxillofaciale, university hospital Estaing, CHU Clermont-Ferrand, 1, place Lucie Aubrac, 63003 Clermont-Ferrand cedex 1, France; UMR Inserm U1107, Neuro-Dol, Trigeminal Pain and Migraine, faculté de chirurgie dentaire, université d'Auvergne, 2, rue de Braga, 63100 Clermont-Ferrand, France. Electronic address:

Mucosal melanoma is a rare malignant disease developed from melanocyte. We report the case of a patient with nasal cavity mucosal melanoma with a primary clinical and histological diagnosis of malignant lentigo with mucosal spreading. The presence of a c-Kit mutation, in a second lecture and the evolving nature of the lesion, reorientated the diagnosis of malignant lentigo to mucosal melanoma with skin extension. Read More

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http://dx.doi.org/10.1016/j.anplas.2019.01.005DOI Listing
February 2019
1 Read

Spontaneous Hair Repigmentation in an 80-Year-Old Man: A Case of Melanoma-Associated Hair Repigmentation and Review of the Literature.

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Geisel School of Medicine at Dartmouth, Hanover, NH.

Spontaneous hair repigmentation of physiologically white or gray hair is a rare occurrence that may be associated with melanoma in elderly individuals. We present the first case of this phenomenon in a man. A gray-haired, 80-year-old man presented to dermatology clinic with a 3-cm lock of black hair on his vertex scalp that developed over 1 year. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001353DOI Listing
January 2019
3 Reads

Nine percent of biopsy proven lentigo maligna are reclassified as lentigo maligna melanoma after surgery.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Lentigo maligna (LM) is a melanoma in situ and the incidence is still rising in The Netherlands. LM is mostly located in the face, therefore radical surgical removal, which is the first choice of treatment, can be challenging in this delicate anatomical region. Staged excision is considered a useful alternative. Read More

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http://dx.doi.org/10.1111/bjd.17714DOI Listing
February 2019

Peutz-Jeghers Syndrome.

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

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http://dx.doi.org/10.1056/NEJMicm1806623DOI Listing
January 2019
1 Read

Long-term outcomes of imiquimod-treated lentigo maligna.

Clin Exp Dermatol 2019 Jan 20. Epub 2019 Jan 20.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Background: Lentigo maligna (LM) may be disfiguring and can progress to LM melanoma. Surgical excision remains the mainstay of treatment, but may result in disfigurement when used for large facial lesions. Topical imiquimod is a nonsurgical alternative although data on its long-term efficacy remain limited. Read More

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http://doi.wiley.com/10.1111/ced.13896
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http://dx.doi.org/10.1111/ced.13896DOI Listing
January 2019
7 Reads

[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1323-1327

Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
 Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
 Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.007DOI Listing
December 2018
4 Reads

Cheek Cutaneous Melanomas: A Review of 98 Cases.

Ann Plast Surg 2019 Jan 9. Epub 2019 Jan 9.

From the Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

Background: Most head and neck melanomas occur on the face, with the cheek being the most frequently affected site. So far, small numbers of researches on cheek melanomas have yielded insufficient and controversial results. In this trial, we aimed to define the histopathological and clinical features specific to cheek melanomas and to compare them with other head and neck melanomas by using a large group of patients from a single tertiary center. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001695DOI Listing
January 2019
1 Read

Teaching Benign Skin Lesions as a Strategy to Improve the Triage Amalgamated Dermoscopic Algorithm (TADA).

J Am Board Fam Med 2019 Jan-Feb;32(1):96-102

From Maine Medical Center, Division of Dermatology, Portland, ME (EVS); Department of Family & Community Medicine (HTA) and Department of Dermatology (AG, MB), Penn State Milton S. Hershey Medical Center, Hershey, PA; Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain (OY); Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY (OY, SWD, AAM).

Introduction: Dermoscopy aids family physicians (FPs) in skin cancer detection. The triage amalgamated dermoscopic algorithm (TADA) was created to simplify the dermoscopic evaluation of a skin growth. The purpose of this image-based study was to evaluate the effect of teaching the clinical and dermoscopic features of benign skin lesions on the diagnostic accuracy of skin cancer identification using TADA. Read More

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http://www.jabfm.org/lookup/doi/10.3122/jabfm.2019.01.180049
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http://dx.doi.org/10.3122/jabfm.2019.01.180049DOI Listing
February 2018
11 Reads

Incidence of melanoma and outcomes of longitudinal melanonychia in a cohort of cases referred to a London dermatology department.

Authors:
Z Jiyad V Akhras

Br J Dermatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Dermatology, St George's Hospital, London, United Kingdom.

Longitudinal melanonychia is a pigmented longitudinal band on the nail plate and may occur due to melanocyte activation, nail matrix nevus, lentigo or subungual melanoma. In a racially diverse community, melanonychia is a relatively common presenting complaint. However, despite this, little is known about the incidence of melanoma in longitudinal melanonychia, as well as variations in management approaches. Read More

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http://dx.doi.org/10.1111/bjd.17607DOI Listing
January 2019
1 Read

Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.

Surv Ophthalmol 2018 Dec 20. Epub 2018 Dec 20.

Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Cutaneous melanoma, a potentially lethal malignancy of the periocular skin, represents only a small proportion of the roughly 87,000 new cases of cutaneous melanoma diagnosed annually in the United States. Most of our understanding of melanoma of the eyelid skin is extrapolated from studies of cutaneous melanoma located elsewhere. Recent years have witnessed major breakthroughs in molecular biology and genomics of cutaneous melanoma, some of which have led to the development of targeted therapies. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.12.002DOI Listing
December 2018
4 Reads

Epidemiological profile of primary cutaneous melanoma over a 15-year period at a private skin cancer center in Colombia.

Rev Salud Publica (Bogota) 2018 Mar-Apr;20(2):226-231

AA: MD. Oncologist Dermatologist Universidad Nacional de Colombia, Universidad Javeriana. Instituto Nacional de Cancerología. Bogotá, Colombia.

Objective : To describe clinical, histopathological and treatment characteristics of melanoma in a private institution of Bogotá, Colombia, and to identify differences regarding sex and age.

Materials And Methods : Observational, retrospective study. 415 medical records between January 1999 and May 2014 were analyzed. Read More

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https://revistas.unal.edu.co/index.php/revsaludpublica/artic
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http://dx.doi.org/10.15446/rsap.V20n2.65616DOI Listing
June 2017
9 Reads

Confocal Microscopy and Lentigo Maligna: An in vivo Pilot Study for the Assessment of Response to Imiquimod Therapy.

Dermatology 2018 Dec 14:1-6. Epub 2018 Dec 14.

Background: Reflectance confocal microscopy (RCM) is a noninvasive technique that provides real-time in vivo images of the epidermal layer. Imiquimod has been recommended as an alternative treatment in lentigo maligna (LM) when surgical excision is not the treatment of choice. In the present study we compare the results of in vivo RCM to the histopathological examination before and after treatment of LM with topical imiquimod. Read More

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http://dx.doi.org/10.1159/000495034DOI Listing
December 2018
1 Read

Evaluation of the Novel Synthetic Tyrosinase Inhibitor ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) and .

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

College of Pharmacy, Pusan National University, Busan 46241, Korea.

Tyrosinase is a key enzyme in melanin synthesis, catalyzing the initial rate-limiting steps of melanin synthesis. Abnormal and excessive melanin synthesis is the primary cause of serious skin disorders including melasma, senile lentigo, freckles, and age spots. In attempts to find potent and safe tyrosinase inhibitors, we designed and synthesized a novel compound, ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498), and evaluated its tyrosinase inhibitory activity and . Read More

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http://dx.doi.org/10.3390/molecules23123307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321646PMC
December 2018
2 Reads

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.

Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).

Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.

Results: Although for the global period LM/LMM represented only 8. Read More

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http://dx.doi.org/10.1111/ijd.14334DOI Listing
December 2018
9 Reads

[Melanonychia].

Ugeskr Laeger 2018 Dec;180(50)

Melanonychia is seen, when melanin is incorporated in the nail, which gives a band of dark discolouration of the nail. Nail discolouration is a common cause for patients to seek medical attention, and it is often benign. Melanonychia can be seen due to melanocytic proliferation (ungual naevi), benign hyperplasia (lentigo) and hypermelanosis (infections, traumas). Read More

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December 2018
1 Read

Reflectance confocal microscopy terminology glossary for non-melanocytic skin lesions: A systematic review.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

Background: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for non-melanocytic lesions (NMLs).

Objective: To review published RCM terms for NMLs and identify likely-synonymous terms.

Methods: Systematic review of original research articles adhering to PRISMA guidelines was conducted until August 19, 2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.007DOI Listing
December 2018
3 Reads

Treatment of benign pigmented lesions using a novel Dermal Cooling System.

Lasers Surg Med 2019 Jan 27;51(1):59-61. Epub 2018 Nov 27.

Department of Dermatology, University of California San Diego, La Jolla 92122, California.

Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Read More

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http://dx.doi.org/10.1002/lsm.23037DOI Listing
January 2019
1 Read

A tiny facial pigmented macule: overcoming the diagnostic challenge.

Dermatol Pract Concept 2018 Oct 31;8(4):322-323. Epub 2018 Oct 31.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

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http://dx.doi.org/10.5826/dpc.0804a15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246060PMC
October 2018
4 Reads

Introduction to reflectance confocal microscopy and its use in clinical practice.

JAAD Case Rep 2018 Nov 10;4(10):1014-1023. Epub 2018 Nov 10.

Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.

Reflectance confocal microscopy (RCM) is a novel technology that provides noninvasive, in vivo imaging of the skin at nearly histologic resolution. In 2016, the US Centers for Medicare and Medicaid Services (CMS) established reimbursement codes for RCM image acquisition and for the reading and interpretation of images. The combination of RCM imaging with dermoscopy has improved the accuracy of skin cancer diagnosis while reducing the number of biopsies of benign skin lesions. Read More

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http://dx.doi.org/10.1016/j.jdcr.2018.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232695PMC
November 2018
9 Reads

Gender differences, UV exposure and risk of lentigo maligna in a nationwide healthcare population cohort study.

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA.

Background: Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence.

Objective: To examine the association of UV light with LM by gender remains unclear. Read More

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http://doi.wiley.com/10.1111/jdv.15348
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http://dx.doi.org/10.1111/jdv.15348DOI Listing
November 2018
8 Reads

Versatility of cervicofacial flaps: Cervical-medial cheek flap for reconstruction in cutaneous substance loss of the inner cheek.

Head Neck 2018 Dec 17;40(12):2574-2582. Epub 2018 Nov 17.

Department of Head and Neck Surgery, Centre Antoine Lacassagne, Nice, France.

Background: Preservation of facial harmony is a major challenge in reconstruction after resection of head and neck skin tumors. For large medial cheek-skin defects, we used a derived posterior-based cervicofacial flap, or cervical-medial cheek flap (CMCF).

Methods: We present a retrospective review of cases treated at a university-based cancer center. Read More

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http://doi.wiley.com/10.1002/hed.25183
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http://dx.doi.org/10.1002/hed.25183DOI Listing
December 2018
9 Reads

Management of Early-Stage Melanoma.

Facial Plast Surg Clin North Am 2019 Feb;27(1):35-42

Department of Dermatology, University of Michigan Medical School, University of Michigan, 1500 East Medical Center Drive, UH South Room F7680, Ann Arbor, MI 48109-5218, USA. Electronic address:

Melanoma is a potentially aggressive skin cancer with a steadily rising incidence. Most melanomas are diagnosed at an early stage and associated with an excellent prognosis when treated appropriately. Primary treatment for melanoma is surgical. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647406183006
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http://dx.doi.org/10.1016/j.fsc.2018.08.003DOI Listing
February 2019
33 Reads

Guidelines of care for the management of primary cutaneous melanoma.

J Am Acad Dermatol 2019 01 1;80(1):208-250. Epub 2018 Nov 1.

American Academy of Dermatology, Rosemont, Illinois.

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183258
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http://dx.doi.org/10.1016/j.jaad.2018.08.055DOI Listing
January 2019
15 Reads

[Lentigo maligna and lentigo maligna melanoma: a clinicopathologic analysis of twenty-four cases].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):769-774

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.007DOI Listing
October 2018
12 Reads

[Spontaneous numbness along with pre-existing deviations in the pigmentation of the lower lip].

Ned Tijdschr Tandheelkd 2018 Oct;125(10):517-523

A 48-year-old man was referred for an evaluation of deviations in the pigmentation of the lower lip, intra-oral swelling and persistent numbness of the sensory area of the left mental nerve. In 2011, the diagnosis lentigo maligna of the lower lip was missed by histopathology of a biopsy performed elsewhere. In 2016, the numbness of the lower lip and chin was diagnosed by a neurologist as numb chin of unknown cause. Read More

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https://www.ntvt.nl/artikel/125/10/een-spontaan-dove-lip-met
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http://dx.doi.org/10.5177/ntvt.2018.10.18142DOI Listing
October 2018
8 Reads

The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management.

Australas J Dermatol 2018 Oct 9. Epub 2018 Oct 9.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.

Background/objectives: There are limited population-based data documenting the incidence and management of lentigo maligna (LM) and invasive lentigo maligna melanoma (LMM). We report the data on occurrence and management of LM and LMM in an Australian population.

Methods: Prospective collection of incidence and clinician-reported management of melanoma in situ (MIS; n = 450, capped) and localised invasive melanoma (n = 3251) notified to the New South Wales Cancer Registry over 12-months in 2006-2007. Read More

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http://doi.wiley.com/10.1111/ajd.12928
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http://dx.doi.org/10.1111/ajd.12928DOI Listing
October 2018
17 Reads

Imiquimod 5% cream in occlusion, for the treatment of lentigo maligna: A new scheme of short cycles and the need for clinical trials.

Dermatol Ther 2019 Jan 4;32(1):e12757. Epub 2018 Nov 4.

Unit of Dermatology, IRCCS University Vita-Salute San Raffaele, Milan, Italy.

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http://doi.wiley.com/10.1111/dth.12757
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http://dx.doi.org/10.1111/dth.12757DOI Listing
January 2019
7 Reads

Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo.

Theranostics 2018 9;8(17):4620-4632. Epub 2018 Sep 9.

Department of Dermatology, Ajou University School of Medicine, Suwon, 443-721, Korea.

Cutaneous ageing is an important extrinsic process that modifies the pigmentary system. Because cellular senescence is a fundamental ageing mechanism, we examined the role of senescent cells in ageing pigmentation. Biopsies obtained from senile lentigo and perilesional normal skin were assayed for a marker of cellular senescence, p16. Read More

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http://www.thno.org/v08p4620.htm
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http://dx.doi.org/10.7150/thno.26975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160768PMC
September 2018
10 Reads

Follicular involvement is frequent in lentigo maligna: Implications for treatment.

J Am Acad Dermatol 2019 Feb 26;80(2):532-537. Epub 2018 Sep 26.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

Background: Follicular involvement of lentigo maligna (LM) is considered a histopathologic hallmark, but its prevalence and characteristics have not been well defined. The depth of intrafollicular extension by neoplastic melanocytes may have clinical importance in the treatment of LM.

Objective: To describe the prevalence and features of follicular involvement in LM, including depth of follicular growth by melanocytes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183262
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http://dx.doi.org/10.1016/j.jaad.2018.07.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333487PMC
February 2019
3 Reads

Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin.

Clin Exp Dermatol 2018 Sep 27. Epub 2018 Sep 27.

Skin Cancer Center Ruhr-University, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.

Recurrence rates of both lentigo maligna (LM) and lentigo maligna melanoma (LMM) following conventional surgery are usually relatively high. We aimed to assess the frequencies of melanocytes in tumour-free margins around LM/LMM using soluble adenylyl cyclase (sAC) immunohistochemistry, and to compare these with those of matched healthy contralateral skin. Using the primary mouse-anti-human sAC antibody R21, we evaluated pan-nuclear melanocytic R21 immunostaining, and found that it was significantly (P < 0. Read More

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http://dx.doi.org/10.1111/ced.13754DOI Listing
September 2018

Dermoscopy findings of a one mm lentigo maligna.

Dermatol Online J 2018 Sep 15;24(7). Epub 2018 Sep 15.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota Department of Dermatology, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota Department of Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota.

A 66-year-old man presented with a grayish 1mm macule on the left cheek. Dermatoscopic examination revealed annular-granular structures partially surrounding a single follicular ostium. Histopathologic examination demonstrated atypical, confluent single melanocytes at the basal layer with nesting, crowding, and upward migration descending along the hair follicle, consistent with the diagnosis of lentigo maligna (LM). Read More

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September 2018
5 Reads

[Peutz-Jegher syndrome presenting with intussusception].

Laeknabladid 2018 Oktober;104(10):439-441

Surgical unit at Landspítali, University Hospital, Iceland.

In this case report we describe a patient with a confirmed diagnosis of Peutz-Jegher syndrome. A diagnosis made from a positive tissue sample from the small bowels and characteristic hyperpigmentation on the patient's lips. This particular patient wasn't diagnosed till he got intussusception which required an operation. Read More

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http://dx.doi.org/10.17992/lbl.2018.10.200DOI Listing
January 2019
1 Read

Clinically amelanotic or hypomelanotic melanoma: Anatomic distribution, risk factors, and survival.

J Am Acad Dermatol 2018 Oct;79(4):645-651.e4

Victorian Melanoma Service, Alfred Health, Melbourne, Australia.

Background: The recognition and diagnosis of clinically amelanotic or hypomelanotic melanoma is a challenge.

Objective: This study aimed to examine the anatomic distribution and risk factors associated with clinically amelanotic or hypomelanotic melanoma and compare the survival of patients with clinically amelanotic or hypomelanotic melanoma with that of patients with pigmented melanoma.

Methods: A prospective cohort study of all cases of primary invasive melanoma managed at a tertiary referral center was performed. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.045DOI Listing
October 2018
2 Reads

Treatment of solar lentigines using a combination of picosecond laser and biophotonic treatment.

Clin Case Rep 2018 Sep 9;6(9):1868-1870. Epub 2018 Aug 9.

FB Dermatology/Kleresca® Borupvang 5C, 2750 Ballerup Denmark.

Treating solar lentigines using picosecond-switched lasers that selectively remove the excess pigment was combined with Kleresca biophotonic treatment. This therapy uses fluorescent light energy to stimulate healing by increasing collagen production and reducing inflammation. Combining these therapies successfully removed solar lentigines and achieved normalized and rejuvenated treated skin. Read More

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http://dx.doi.org/10.1002/ccr3.1749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132099PMC
September 2018
1 Read

A Practical Approach to Chemical Peels: A Review of Fundamentals and Step-by-step Algorithmic Protocol for Treatment.

J Clin Aesthet Dermatol 2018 Aug 1;11(8):21-28. Epub 2018 Aug 1.

Drs. Soleymani, Lanoue, and Rahman are with the Department of Dermatology at Stanford University School of Medicine in Redwood City, California.

Chemoexfoliation, also known as chemical peeling, is a method of targeted cutaneous ablation using specific caustic agents that allow for rapid, predictable, and uniform thickness of chemoablation to a desired cutaneous depth, ultimately resulting in an improved appearance of skin. In this review, we provide an up-to-date analysis of all currently available chemical peels for dermatologic use, as well as a step-by-step instructional protocol for an algorithmic approach to treatment. A comprehensive search of the Cochrane Library, MEDLINE, and PUBMED databases was performed to identify relevant literature investigating chemical peeling agents. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122508PMC

Use of immune checkpoint inhibitors prolonged overall survival in a Japanese population of advanced malignant melanoma patients: Retrospective single institutional study.

J Dermatol 2018 Nov 11;45(11):1337-1339. Epub 2018 Sep 11.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised mainly white populations, in which superficial spreading melanoma (SSM) and lentigo maligna melanoma are the major clinical types of melanoma. In contrast, Asians manifest a distinct clinicopathological type of melanoma from that of whites and show much higher frequencies of acral lentiginous melanoma (ALM) and mucosal melanoma, which have been shown to be less susceptible to immune checkpoint inhibitors. Because no comparative studies have been published showing improvement of OS by immune checkpoint inhibitors in Asian melanoma patients, we retrospectively collected the data for 45 melanoma patients treated with checkpoint inhibitors and 24 melanoma patients treated with chemotherapy alone before immune checkpoint inhibitors became available, and compared their OS. Read More

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http://dx.doi.org/10.1111/1346-8138.14637DOI Listing
November 2018
11 Reads

Locally recurrent lentigo maligna within a skin graft: a case report.

ANZ J Surg 2018 Sep 11. Epub 2018 Sep 11.

Plastic Surgery, St Vincent's Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ans.14492DOI Listing
September 2018
1 Read
1.120 Impact Factor

Melanocytic Lesions of the Nail Unit.

Dermatopathology (Basel) 2018 Jul-Sep;5(3):98-107. Epub 2018 Jul 24.

Department of Dermatology, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Melanocytic lesions of the nail unit are traditionally classified as follows: melanocytic activation, lentigo, nevi, and melanoma. Undoubtedly, melanoma is the most important malignant tumor of the nail unit. Differentiating nail unit melanoma from other melanocytic lesions is often difficult both clinically and histopathologically. Read More

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https://www.karger.com/Article/FullText/490557
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http://dx.doi.org/10.1159/000490557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120410PMC
July 2018
10 Reads

Palpebral cutaneous melanomas: a review of 17 cases from a tertiary center.

Int J Dermatol 2019 Jan 31;58(1):75-79. Epub 2018 Aug 31.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

Background: Melanomas arising from eyelid skin are exceptionally rare, accounting for <1% of eyelid malignancies and all cutaneous melanomas. The aim of this study was to identify the histopathological features and clinical behaviors of the palpebral skin melanoma patients from a single tertiary institution.

Patients And Methods: Seventeen Caucasian patients diagnosed with eyelid cutaneous melanoma were analyzed retrospectively. Read More

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http://dx.doi.org/10.1111/ijd.14212DOI Listing
January 2019
2 Reads

Clinical spectrum of cutaneous melanoma morphology.

J Am Acad Dermatol 2019 Jan 28;80(1):178-188.e3. Epub 2018 Aug 28.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.

Objective: To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features.

Methods: All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Read More

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http://dx.doi.org/10.1016/j.jaad.2018.08.028DOI Listing
January 2019
29 Reads
4.450 Impact Factor

Widespread keratosis pilaris in a patient with Noonan syndrome with multiple lentigines.

Int J Dermatol 2018 11 27;57(11):e140-e141. Epub 2018 Aug 27.

Department of Dermatology, University of Health Sciences, Ankara Numune Training and Research Hospital, Ankara, Turkey.

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http://doi.wiley.com/10.1111/ijd.14209
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http://dx.doi.org/10.1111/ijd.14209DOI Listing
November 2018
5 Reads

3D microvascular analysis reveals irregularly branching blood vessels in the hyperpigmented skin of solar lentigo.

Pigment Cell Melanoma Res 2018 Nov 30;31(6):725-727. Epub 2018 Aug 30.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1111/pcmr.12731DOI Listing
November 2018
1 Read

Dermatoscopy of flat pigmented facial lesions-evolution of lentigo maligna diagnostic criteria.

Dermatol Pract Concept 2018 Jul 31;8(3):198-203. Epub 2018 Jul 31.

Department of Dermatology and Venereology, Centro Hospitalar São João, EPE Porto, Portugal.

Recognition of facial lentigo maligna (LM) is often difficult, particularly at early stages. Algorithms and multivariate diagnostic models have recently been elaborated on the attempt to improve the diagnostic accuracy. We conducted a cross-sectional and retrospective study to evaluate dermatoscopic criteria aiding in diagnosis of flat pigmented facial lesions (FPFL). Read More

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https://www.derm101.com/dpc/july-2018-volume-8-no.3/dp0803a1
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http://dx.doi.org/10.5826/dpc.0803a10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092074PMC
July 2018
14 Reads

Challenging facial pigmented lesions: values and limits of confocal microscopy.

Dermatol Pract Concept 2018 Jul 31;8(3):188-190. Epub 2018 Jul 31.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.5826/dpc.0803a08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092073PMC
July 2018
3 Reads

Experience with Treating Lentigo Maligna with Definitive Radiotherapy.

Dermatol Res Pract 2018 15;2018:7439807. Epub 2018 Jul 15.

Melanoma Institute Australia, Poche Centre, Crows Nest, Australia.

Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a histopathology report that records completion of excision. Some patients may not be surgical candidates due to comorbidities, patient preference, impact on function, and cosmesis or they have failed surgery with a positive margin. Read More

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http://dx.doi.org/10.1155/2018/7439807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076978PMC
July 2018
19 Reads

Evaluating the Diagnostic Accuracy of Reflectance Confocal Microscopy to Diagnose Skin Cancer: Protocol for a Prospective, Multicenter Study.

JMIR Res Protoc 2018 Aug 9;7(8):e170. Epub 2018 Aug 9.

Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: In the United Kingdom, 350,000 patients per year are referred to hospital clinics with suspicious moles, and approximately half undergo a biopsy to identify the 5%-10% who require further treatment. If cancer cannot be ruled out clinically and on the basis of biopsy results, the lesion is surgically removed. One type of precancerous mole, called lentigo maligna, is particularly challenging to delineate and treat. Read More

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http://dx.doi.org/10.2196/resprot.9296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107731PMC
August 2018
8 Reads