4,926 results match your criteria Lentigo


Treatment of solar lentigo with imiquimod 3.75% cream: a dermoscopic study.

J Cosmet Dermatol 2022 Jun 24. Epub 2022 Jun 24.

Dermatology Unit, Papardo Hospital, Messina, Italy.

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[Translated article] Wood's Lamp for Delineating Surgical Margins in Lentigo Maligna and Lentigo Maligna Melanoma.

Actas Dermosifiliogr 2022 Jun 4;113(6):T642-T645. Epub 2022 May 4.

Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain.

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Clinical features associated with the invasive component in lentigo maligna of the head and neck: A retrospective study of 175 cases.

Ann Dermatol Venereol 2022 Jun 20. Epub 2022 Jun 20.

Department of Dermatology, CHU, Bordeaux, France; INSERM U1053, Bordeaux Research in Translational Oncology, Université Bordeaux, Bordeaux, France.

Background: Lentigo maligna (LM) can develop into lentigo maligna melanoma (LMM) with risk of metastatic dissemination. LMM may be underestimated on the basis of the initial biopsy. The invasion may affect both the therapeutic options and the prognosis. Read More

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New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application.

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:38-50

Dermatology Unit, University of Campania, Naples, Italy.

The incidence of non-melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High-resolution non-invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Read More

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Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy proven lentigo maligna.

J Eur Acad Dermatol Venereol 2022 Jun 22. Epub 2022 Jun 22.

Erasmus MC Cancer institute, University Medical Center Rotterdam, The Netherlands, Department of Dermatology.

Background: Lentigo maligna (LM) based on biopsy material might be lentigo maligna melanoma (LMM) after excision.

Objectives: Investigate whether clinical and dermoscopic mapping increases the detection rate of LMM when investigating staged excision specimens of biopsy proven LM.

Methods: Patients with biopsy proven LM planned for staged excision were included. Read More

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Efficacy and safety of topical hydrogen peroxide 35% solution versus cryotherapy in the treatment of senile lentigo.

J Cosmet Dermatol 2022 Jun 20. Epub 2022 Jun 20.

Skin Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran.

Background: Senile lentigines (SLs) are hyperpigmented macules that predominantly affect the elderly. We aimed to compare the efficacy and safety of hydrogen peroxide35% solution with cryotherapy in the treatment of SLs.

Patients And Methods: This clinical trial included 33 patients with SLs referred to our center. Read More

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Cutaneous melanoma incidence, mortality, and survival in Manizales, Colombia: a population-based study.

J Int Med Res 2022 Jun;50(6):3000605221106706

Population-based Manizales Cancer Registry, Instituto de Investigaciones en Salud, Universidad de Caldas, Manizales, Colombia.

Objective: We estimated the cutaneous melanoma (CM) incidence, mortality, and survival in Manizales, Colombia to establish predictors for survival.

Methods: This analytical cohort study used CM incident cases during 2006 to 2015 in the Manizales Cancer Registry (n = 132). Incidence and mortality rates were standardized using the direct method. Read More

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Practical application of laser reflectance confocal microscopy in the follow-up of patients with lentigo maligna undergoing treatment with Imiquimod.

An Bras Dermatol 2022 Jun 9. Epub 2022 Jun 9.

Dermatology Oncology Outpatient Clinic, Department of Internal Medicine, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

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Endoscopic Therapy of Small Bowel Polyps by Single-Balloon Enteroscopy in Patients with Peutz-Jeghers Syndrome.

Int J Clin Pract 2022 1;2022:7849055. Epub 2022 Feb 1.

Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Background: Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz-Jeghers syndrome (PJS). The aim of this study was to assess the efficacy and safety of SBE for the treatment of small bowel polyps in patients with PJS.

Methods: We conducted a single-center observational study, which included all patients diagnosed with PJS who underwent SBE for polypectomy between January 2018 and March 2021. Read More

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Continuing Medical Education Questions: June 2022.

Authors:
Akwi W Asombang

Am J Gastroenterol 2022 Jun 17;117(6):844. Epub 2022 Feb 17.

Massachusetts General Hospital, Boston, Massachusetts.

Article Title: Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Read More

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A rare cause of mechanical intestinal obstruction due to small bowel intussusception: 'A solitary Peutz-Jeghers type hamartomatous polyp'.

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):879-883

Department of General Surgery, Trakya University Faculty of Medicine, Edirne-Turkey.

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder which is characterized by hyperpigmentation in mucocutaneous membranes and hamartomatous polyps in the gastrointestinal tract (GIT). Common complications reported in patients with PSJ are bleeding and mechanical intestinal obstruction due to the hamartomatous polyps. There is also an increased risk of gastrointestinal and extra-intestinal malignancies in patients with PJS. Read More

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Reactive Pigmentation of Skin Graft Mimicking a Lentigo Maligna Recurrence: a Case Report.

Dermatol Pract Concept 2022 May 1;12(2):e2022054. Epub 2022 Apr 1.

Pathology Section, Oncology Institute, Fundación Arturo López Pérez (FALP), Santiago, Chile.

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From the Cochrane Library: Interventions for Melanoma in Situ, Including Lentigo Maligna.

J Am Acad Dermatol 2022 May 28. Epub 2022 May 28.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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Series of Fourteen Cases of Topical Imiquimod 5% in Lentigo Maligna: Treatment Modalities and Clues for Detecting Recurrences.

Actas Dermosifiliogr 2022 Apr 3;113(4):T407-T412. Epub 2021 Dec 3.

Departamento de Dermatología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España; Unidad de Dermatología Área, Departamento de Medicina Clínica, Universidad Miguel Hernández, Sant Joan de Alicante, Alicante, España.

Topical imiquimod has been used off-label as monotherapy or adjuvant treatment for lentigo maligna. Our aim is to describe treatment modalities, clinical outcomes, and management of recurrence in patients receiving imiquimod for lentigo maligna. Patients from our unit with lentigo maligna or lentigo maligna melanoma treated with imiquimod 5% as monotherapy or in combination with surgery were included in this study. Read More

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Subungual Melanocytic Lesions in Pediatric Patients.

Actas Dermosifiliogr 2022 Apr 11;113(4):388-400. Epub 2021 Nov 11.

Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, Valencia, España.

The study of subungual melanocytic lesions can present challenges because of the clinical and histologic characteristics of the nail unit and the difficulty of performing nail biopsies and processing specimens. These lesions can be even more challenging in children due to differences in clinical and epidemiological profiles between the adult and pediatric populations. Many of the clinical features of subungual melanocytic lesions that would raise alarm in an adult do not have the same implications in children. Read More

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Development of patient decision aids for the treatment of lentigo maligna and low-risk basal cell carcinoma.

J Am Acad Dermatol 2022 May 21. Epub 2022 May 21.

Department of Dermatology, Memorial Sloan Kettering Cancer Center, Dermatology Service, New York, New York.

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Variation in second cancer risk by melanoma subtype among survivors.

J Am Acad Dermatol 2022 May 16. Epub 2022 May 16.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland. Electronic address:

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[A case of Peutz-Jeghers syndrome that developed triple cancers during the course].

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(5):446-451

Department of Gastroenterology and Hepatology, Okayama University Hospital.

At the time of colon polyp follow-up, a 46-year-old Japanese woman with a history of invagination, colon polyps, cervical cancer, and breast cancer was suspected of Peutz-Jeghers syndrome and referred. Multiple polyposes of the jejunum were discovered by capsule endoscopy and double-balloon endoscopy, and the resected specimen was diagnosed with hamartoma. During the follow-up, advanced pancreatic cancer-derived from IPMN developed. Read More

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Lung cancer as a predominant feature in a patient with Peutz-Jeghers syndrome: Case report.

Thorac Cancer 2022 Jun 11;13(12):1862-1865. Epub 2022 May 11.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

Peutz-Jeghers syndrome (PJS) is characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyposis, which can lead to intussusception. PJS patients face high lifetime risks for various cancer types, with the majority of patients being diagnosed with tumors along the gastrointestinal tract. Herein, we present the case of a 34-year-old man who carried a germline STK11 pathogenic variant, while lacking the cardinal features of PJS syndrome. Read More

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Lentigo Maligna of the head and neck: A retrospective study assessing surgical excision margins in a South African population.

JAAD Int 2022 Jun 28;7:169-176. Epub 2022 Apr 28.

Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town, South Africa.

Background: Lentigo maligna (LM) is a subtype of melanoma in situ that occurs on sun-damaged skin and is associated with significant subclinical extension beyond the clinical margins of the lesion.

Objectives: This study aimed to determine if the standard recommended tumor excision margins for LM are adequate to achieve a 97% clearance rate and if any patient or tumor characteristics warranted wider margins.

Methods: This study is a retrospective chart review of all patients who were diagnosed with LM of the head and neck and treated with staged excision. Read More

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Complex management of lentigo maligna in the setting of chrysiasis, argyriasis, and tattoo using in vivo reflectance confocal microscopy.

J Dermatol 2022 May 5. Epub 2022 May 5.

The Melanoma Institute of Australia, New South Wales, Australia.

Lentigo maligna (LM) can be difficult to diagnose and recurrence is not uncommon. In vivo reflectance confocal microscopy (RCM) improves diagnostic accuracy of LM. LM can be difficult to discern from coexistent metal-induced cutaneous hyperpigmentation (MICH). Read More

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The Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspects.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, Dental School, University of Sao Paulo, Sao Paulo, Brazil; and.

Abstract: Oral pigmentations are a heterogeneous group and can be the result of physiological activity of oral mucosal melanocytes, secondary to exogenous causes, associated with systemic or local diseases, or due to proliferative activity of melanocytes. Their diagnosis is critical because these lesions can be markers of internal diseases or, in the case of melanocytic proliferative processes, they may represent a malignant neoplasm. In the past decade, the use of reflectance confocal microscopy, a noninvasive imaging tool, has aided the analysis of such lesions, but the establishment of firm criteria in their evaluation is still lacking. Read More

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Classification and Staging of Melanoma in the Head and Neck.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234

Division of Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine,- Jacksonville 653-1 West 8th, Street, Jacksonville, FL 32209, USA.

The rates of melanoma continue to rise, with recent estimates have shown that 18% to 22% of new melanoma cases occur within the head and neck in the United States each year. The mainstay of treatment of nonmetastatic primary melanomas of the head and neck includes the surgical resection and management of regional disease as indicated. Thorough knowledge of the classification and staging of melanoma is paramount to evaluate prognosis, determine the appropriate surgical intervention, and assess eligibility for adjuvant therapy and clinic trials. Read More

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Introduction to Head and Neck Melanoma: A Dermatologist's Perspective.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):213-220

Caremount Medical, Poughkeepsie, NY, USA.

Melanoma is often initially evaluated by the dermatologist. A methodical evaluation requires complete history and detailed clinical physical examination and appropriate decisions regarding biopsies. Accurate diagnosis and staging require clinicopathologic correlation and an excellent relationship with the dermatopathologist. Read More

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Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer.

Gastroenterology 2022 Jun 26;162(7):2063-2085. Epub 2022 Apr 26.

Veterans Affairs Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant disorders associated with an increased risk of benign and malignant intestinal and extraintestinal tumors. They include Peutz-Jeghers syndrome, juvenile polyposis syndrome, the PTEN hamartoma tumor syndrome (including Cowden's syndrome and Bannayan-Riley-Ruvalcaba syndrome), and hereditary mixed polyposis syndrome. Diagnoses are based on clinical criteria and, in some cases, confirmed by demonstrating the presence of a germline pathogenic variant. Read More

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Diagnosis and management of cancer risk in the gastrointestinal hamartomatous polyposis syndromes: recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer.

Gastrointest Endosc 2022 Jun 26;95(6):1025-1047. Epub 2022 Apr 26.

Veterans Affairs Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant disorders associated with an increased risk of benign and malignant intestinal and extraintestinal tumors. They include Peutz-Jeghers syndrome, juvenile polyposis syndrome, the PTEN hamartoma tumor syndrome (including Cowden's syndrome and Bannayan-Riley-Ruvalcaba syndrome), and hereditary mixed polyposis syndrome. Diagnoses are based on clinical criteria and, in some cases, confirmed by demonstrating the presence of a germline pathogenic variant. Read More

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Peutz-Jeghers syndrome: Evidence-based decision-making, regarding a case.

Rev Gastroenterol Mex (Engl Ed) 2022 Apr-Jun;87(2):263-265. Epub 2022 Apr 25.

Departamento de Gastroenterología, Hospital de Especialidades Puebla, Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico. Electronic address:

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Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer.

Am J Gastroenterol 2022 06 26;117(6):846-864. Epub 2022 Apr 26.

Veterans Affairs Medical Center, White River Junction, Vermont, USA.

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant disorders associated with an increased risk of benign and malignant intestinal and extraintestinal tumors. They include Peutz-Jeghers syndrome, juvenile polyposis syndrome, the PTEN hamartoma tumor syndrome (including Cowden's syndrome and Bannayan-Riley-Ruvalcaba syndrome), and hereditary mixed polyposis syndrome. Diagnoses are based on clinical criteria and, in some cases, confirmed by demonstrating the presence of a germline pathogenic variant. Read More

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