4,573 results match your criteria Lentigo


A Retrospective Analysis of Er:YAG Laser Treatment in Solar Lentigines: Our Clinical Observations.

Sisli Etfal Hastan Tip Bul 2020 18;54(2):193-196. Epub 2020 May 18.

Department of Dermatology and Venereology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey.

Objectives: To investigate the efficacy of erbium-doped yttrium aluminium garnet (Er:YAG) laser in the treatment of solar lentigines.

Methods: A retrospective study was conducted on patients treated with the only Er:YAG laser. In this study, 14 patients with multiple solar lentigines before treatment were included. Read More

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http://dx.doi.org/10.14744/SEMB.2018.46548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326671PMC

The dermatoscopic inverse approach significantly improves the accuracy of human readers for lentigo maligna diagnosis.

J Am Acad Dermatol 2020 Jun 24. Epub 2020 Jun 24.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: A recently introduced dermatoscopic method for diagnosis of early lentigo maligna (LM) is based on the absence of prevalent patterns of pigmented actinic keratosis (PAK) and solar lentigo/flat seborrheic keratosis (SL/SK). We term this the "inverse approach" OBJECTIVE: To determine whether training on the inverse approach increases the diagnostic accuracy of readers as compared to classic pattern analysis.

Methods: We used clinical and dermatoscopic images of histopathologically diagnosed LMs, PAKs and SLs/SKs. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.085DOI Listing

Reflectance confocal microscopy. Part II. Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathological correlates of key confocal criteria, and diagnostic algorithms.

J Am Acad Dermatol 2020 Jun 18. Epub 2020 Jun 18.

The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Dermatology Service, Memorial Sloan-Kettering Center, New York, NY.

Reflectance confocal microscopy (RCM) is a high-resolution, non-invasive tool currently FDA-approved for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing biopsy of benign lesions. Part II of this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers-melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions-melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus-like keratosis, and sebaceous hyperplasia. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.154DOI Listing

Lentigo Maligna Melanoma In-Situ with Neurotropism.

J Cutan Pathol 2020 Jun 18. Epub 2020 Jun 18.

Department of Pathology, New York University Langone Health, New York, NY.

Perineural invasion, or neurotropism, is defined by the presence of cancer cells either within the neuronal sheath or found along the nerves. In melanoma, it is most commonly associated with invasive desmoplastic melanoma, a melanoma that is most commonly associated with malignant melanoma in situ, lentigo maligna type. Initially, perineural invasion was included in the reported Breslow thickness, however, recent data suggests that it should not be included. Read More

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http://dx.doi.org/10.1111/cup.13778DOI Listing

Cutaneous Head and Neck Melanoma: Changes in Clinical and Histologic Features From 1995 to 2015 in a Tertiary Hospital in Madrid, Spain.

Actas Dermosifiliogr 2020 Jun 12. Epub 2020 Jun 12.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Objectives: Few epidemiological studies have analyzed cutaneous head and neck melanoma (CHNM) in the Spanish population. The aim of this study was to describe the clinical and histologic features of a representative sample of CHNM in Spain and to analyze changes observed over a period of 21 years.

Material And Methods: Descriptive, retrospective, cross-sectional study of 280 patients diagnosed with CHNM at Hospital General Universitario Gregorio Marañón in Madrid, Spain, between January 1, 1995, and December 31, 2015. Read More

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http://dx.doi.org/10.1016/j.ad.2019.12.002DOI Listing

Change of the diagnostic distribution in applicants to dermatology after COVID-19 pandemic: What it whispers to us?

Dermatol Ther 2020 Jun 12:e13804. Epub 2020 Jun 12.

Department of Dermatology and Venereology, the Republic of Turkey, Health Sciences University Erzurum Regional Training and Research Hospital, Turkey.

We aim to evaluate the change in the diagnostic spectrum in dermatology outpatient applications compared to before COVID-19. All patients were enrolled from the Department of Dermatology between February 12 and May 8, 2020, the duration of 4 weeks before COVID-19 and eight weeks after were analyzed in 3 parts consisting of 4 weeks. Data obtained from the database such as age, gender, diagnoses were anonymized. Read More

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http://dx.doi.org/10.1111/dth.13804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300472PMC

Holistic Patient Assessment: Dermatology in Dental Practice.

Prim Dent J 2020 Mar;9(1):37-42

Consultant Oral and Maxillofacial Surgeon, King's College Hospital, Reader in Oral and Maxillofacial Surgery, King's College London.

As part of the holistic approach to their patients, General Dental Practitioners are well placed to identify common skin lesions. Awareness and recognition of worrying lesions allow timely and appropriate referrals for further investigation and treatment. In this paper, we review benign, premalignant and malignant skin lesions, as well as genetic skin conditions. Read More

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http://dx.doi.org/10.1177/2050168420911028DOI Listing

Junctional Melanocytic Hyperplasia Overlying Benign Fibrous Papule: An Under-recognized Variant of a Common Lesion.

J Cutan Pathol 2020 Jun 4. Epub 2020 Jun 4.

Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Fibrous papule (angiofibroma) is a common benign tumor often presenting as an erythematous papule on the face of an adult, most commonly on the nose. The clinical differential diagnosis is often fibrous papule, basal cell carcinoma, or intradermal nevus. A number of histologic variants of fibrous papule are described, including a variant with junctional melanocytic hyperplasia that can resemble lentigo maligna. Read More

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http://dx.doi.org/10.1111/cup.13767DOI Listing

Staged Excision With Micrographic Monitoring of Margins in Lentigo Maligna.

Actas Dermosifiliogr 2020 May 26. Epub 2020 May 26.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España; Escuela de Medicina, Universidad Católica de Valencia San Vicente Mártir, Valencia, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2019.09.005DOI Listing

Epidemiology of Melanoma in the Czech Republic in East Bohemia in the Period 2002-2017 and the Effect of the Annual Sunshine Exposure.

Acta Medica (Hradec Kralove) 2020 ;63(1):10-17

Department of Dermatology and Venereology Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Aim: The evaluation of the trend in the occurrence of melanoma nodulare, melanoma superficiale, lentigo maligna and melanoma in situ in the period of 2002-2017 in East Bohemia region in the Czech Republic. We examine if the annual numbers of hours of sunshine could affect the number of patients with melanoma.

Method: In the peridod of 2002-2017, altogether 2230 patients with new diagnosis of melanoma were examined. Read More

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http://dx.doi.org/10.14712/18059694.2020.10DOI Listing
January 2020

Superficial dermal melanocytosis of the elderly: An exceptional occurrence?

J Cutan Pathol 2020 May 10. Epub 2020 May 10.

Dermatopathology Bodensee, Friedrichshafen, Germany.

The development of flat pigmented lesions on chronically sun-damaged (CSD) skin of the face may represent the clinical manifestation of a wide variety of hyperplastic/neoplastic melanocytic proliferations. We report the exceptional case of an acquired pigmented patch occurring on CSD skin, histopathologically characterized by diffuse hyperplasia of dendritic/spindled melanocytes in the superficial dermis within a widened band of actinic elastosis. This lesion was associated with a small focus of early invasive lentigo maligna melanoma (LMM). Read More

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http://dx.doi.org/10.1111/cup.13737DOI Listing

Should topical imiquimod be used for positive margins in lentigo maligna?

J Am Acad Dermatol 2020 May 6. Epub 2020 May 6.

University of Toledo College of Medicine, Toledo, Ohio.

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http://dx.doi.org/10.1016/j.jaad.2020.02.087DOI Listing

Lentigo maligna in a patient with xeroderma pigmentosum, variant type: A case report with dermoscopic findings and review of the literature.

Photodermatol Photoimmunol Photomed 2020 May 7. Epub 2020 May 7.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/phpp.12568DOI Listing

Inflammatory features and rete ridge patterns of facial solar lentigo may guide laser treatment.

Dermatol Ther 2020 Apr 27:e13464. Epub 2020 Apr 27.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Relatively little is known about the clinicopathological characteristics of solar lentigo (SL), rendering the choice of laser treatment a clinical challenge. This study compared the clinicohistopathological characteristics of patients with SL on the face with and without conspicuous inflammation. The medical records were evaluated to determine the clinical and histopathological characteristics. Read More

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http://dx.doi.org/10.1111/dth.13464DOI Listing

Zigzag longitudinal melanonychia: a peculiar dermoscopic pattern.

J Eur Acad Dermatol Venereol 2020 Apr 22. Epub 2020 Apr 22.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: Longitudinal melanonychia (LM) can present a diagnostic challenge and dermoscopy is of utmost importance for its evaluation and differential diagnosis of LM.

Objective: This report aimed to describe an unusual dermoscopic pattern in a group of patients that presented with LM.

Methods: The clinical course and features of five LM patients that presented with an unusual 'zigzag' dermoscopic pattern were analyzed retrospectively. Read More

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http://dx.doi.org/10.1111/jdv.16517DOI Listing

Benefits of Teledermatology for Geriatric Patients: Population-Based Cross-Sectional Study.

J Med Internet Res 2020 Apr 21;22(4):e16700. Epub 2020 Apr 21.

Telemedicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: Teledermatology is a health care tool that has been increasingly used around the world, mostly because dermatology has an emphasis on visual diagnosis. Many studies have shown that access to specialized care improves using teledermatology, which provides accurate diagnosis and reduces the time taken for treatment, with high patient satisfaction. As the population around the world grows old, there will be even more demand for dermatologists in years to come. Read More

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http://dx.doi.org/10.2196/16700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201316PMC

Clinicopathologic diversity and outcome of longitudinal melanonychia in children and adolescents: Analysis of 35 cases identified by excision specimens.

Histopathology 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, First People's Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.

Aims: Longitudinal melanonychia in pediatric patients often represents a difficult diagnostic challenge and studies emphasizing on its clinical and histopathologic features are limited due to its low incidence in childhood.

Methods And Results: We retrospectively analyzed 35 pediatric cases identified by excision specimens on their clinicopathologic features, and performed fluorescence in situ hybridization test on available 13 cases. Fingernails (77. Read More

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http://dx.doi.org/10.1111/his.14121DOI Listing

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus.

Skin Res Technol 2020 Apr 6. Epub 2020 Apr 6.

Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To investigate the application and challenge of reflectance confocal microscopy (RCM) in the diagnosis of pigmented nevus.

Method: A total of 997 patients with clinical diagnosis of pigmented nevus were included in the study, and RCM imaging was performed on the lesion of each patient. A biopsy was performed in 78 of these patients for histological diagnosis. Read More

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http://dx.doi.org/10.1111/srt.12854DOI Listing

Emerging role of dermal compartment in skin pigmentation: comprehensive review.

J Eur Acad Dermatol Venereol 2020 Apr 3. Epub 2020 Apr 3.

Department of Dermatology, PGIMER, Chandigarh, India.

The variations in human skin colour mainly occur due to differences in the distribution of melanin pigment throughout the body, synthesized by epidermal melanocytes which are further taken up by keratinocytes present in epidermis. Recently, it has been discovered that besides these cells, dermis derived fibroblast factors also play a prominent role in regulating skin pigmentation. There exists a signal crosstalk between epidermal melanocytes, keratinocytes and dermal fibroblasts and any impairment in these signalling pathways may give rise to pigmentary disorders. Read More

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http://dx.doi.org/10.1111/jdv.16404DOI Listing
April 2020
2.826 Impact Factor

Clinical management of very small pigmented lesions: Improved clinical outcome through dermoscopy and reflectance confocal microscopy combination.

Skin Res Technol 2020 Mar 24. Epub 2020 Mar 24.

Clinical Dermatology, San Gallicano Dermatological Institute-IRCCS, Rome, Italy.

Introduction: Small-sized pigmented lesions (SSPL) <3 mm in diameter are common pitfall in the daily dermatology practice. Dermoscopy alone is hampered by the lack of specific features inversely proportional to the diameter of the lesions and its performance is highly operator-dependent. Reflectance confocal microscopy (RCM) has been demonstrated to be effective in the diagnosis of several difficult lesions where dermoscopy lacks to provide conclusive information. Read More

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http://dx.doi.org/10.1111/srt.12863DOI Listing

SOX-10 and S100 Negative Desmoplastic Melanoma: Apropos a Diagnostically Challenging Case.

Am J Dermatopathol 2020 Feb 25. Epub 2020 Feb 25.

Dermatology Section, Department of Medicine, VA Boston Healthcare System, Boston, MA.

An 83-year-old man presented with a tumor of the neck, clinically consistent with an epidermal inclusion cyst. Excisional biopsy revealed a deeply infiltrating spindled cell tumor. Immunohistochemical markers for S100, SOX-10, Melan-A, HMB-45, and NK1/C3 were negative. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001626DOI Listing
February 2020

Lentigo maligna and intensified ablative fractional laser-assisted PDT: a promising, minimally invasive treatment approach.

Authors:
L Marini S Marini

J Eur Acad Dermatol Venereol 2020 03;34(3):440-441

Queen's University School of Medicine, Belfast, UK.

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http://dx.doi.org/10.1111/jdv.16262DOI Listing

The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.

Arch Pathol Lab Med 2020 Apr 14;144(4):500-522. Epub 2020 Feb 14.

From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Dr Elder); the Department of Dermatology, University of California San Francisco, San Francisco (Dr Bastian); International Agency for Research on Cancer, Lyon, France (Dr Cree); Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy (Dr Massi); and the Department of Pathology and Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Scolyer).

Context.—: There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0561-RADOI Listing

Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation.

J Cosmet Dermatol 2020 Feb 13. Epub 2020 Feb 13.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Extrinsic skin aging caused by atmospheric pollutants is associated with a sustained inflammatory response which is a significant risk factor for lentigines and melasma.

Aims: The aim of this study was to evaluate the efficacy of topical application of combination formulation of vitamin C, vitamin E, and ferulic acid as an adjuvant to Q-switched Nd:YAG (QSNY) lasers treatment in individuals with lentigines and melasma.

Methods: A single blinded, prospective, randomized split-face trial was conducted. Read More

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http://dx.doi.org/10.1111/jocd.13323DOI Listing
February 2020
1.000 Impact Factor

Retrospective photographic review of nontattoo indications treated by picosecond laser.

J Cosmet Dermatol 2020 Mar;19(3):612-621

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation.

Objective: We report our experience treating our patients for different indications using a PS laser. Read More

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http://dx.doi.org/10.1111/jocd.13285DOI Listing

Efficacy of imiquimod 3.75% cream for the treatment of solar lentigo.

Dermatol Ther 2020 Mar 16;33(2):e13256. Epub 2020 Feb 16.

Unit of Dermatology, Policlinico Umberto I Hospital, Sapienza Medical School University of Rome, Rome, Italy.

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http://dx.doi.org/10.1111/dth.13256DOI Listing

Incompletely excised lentigo maligna melanoma is associated with unpredictable residual disease: clinical features and the emerging role of reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2020 Feb 7. Epub 2020 Feb 7.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Lentigo maligna/lentigo maligna melanoma (LM/LMM) poses a treatment and surgical challenge given unpredictable subclinical extension resulting in incomplete excision.

Objectives: To describe the demographic, clinical and pathologic characteristics of incompletely excised LM/LMM. To evaluate the potential role of reflectance confocal microscopy (RCM). Read More

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http://dx.doi.org/10.1111/jdv.16272DOI Listing
February 2020

Progressive Disease in Sentinel-negative Melanoma Patients: Biological Differences and Importance of Sentinel Lymph Node Biopsy.

Anticancer Res 2020 Feb;40(2):891-899

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland

Background/aim: Among the most important prognostic factors in melanoma is the sentinel lymph node (SLN) status.

Materials And Methods: Using our electronic database we identified 109 of 890 SLN-negative patients with progressive disease (PD). These patients were characterized for melanoma type, molecular type, sequence and extent of metastatic spread. Read More

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http://dx.doi.org/10.21873/anticanres.14022DOI Listing
February 2020

[Facial skin cancers: Comparison of opinions in French multidisciplinary team meetings].

Ann Dermatol Venereol 2020 Mar 28;147(3):179-187. Epub 2020 Jan 28.

Service de dermatologie, CHU Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.

Background: The aim of our study was to evaluate the diversity, or homogeneity, of recommendations made in multidisciplinary team meetings (MTM) concerning the management of facial skin cancers in France, and to analyze the determinants thereof.

Patients And Methods: We contacted a panel of dermatology and ENT multidisciplinary teams (MDT) and collected their recommendations made at meetings regarding 3 clinical cases: squamous cell carcinoma in a renal transplant patient with an incomplete excision margin (case 1), locally advanced basal cell carcinoma (case 2), and lentigo maligna (case 3). The responses were analyzed globally and then based on 2 subgroups defined by the presence or absence of a dermatologist in the MTM. Read More

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http://dx.doi.org/10.1016/j.annder.2019.09.614DOI Listing

Upstaging of melanoma in situ and lentigo maligna treated with Mohs micrographic surgery rarely results in additional surgical management.

Arch Dermatol Res 2020 Jan 30. Epub 2020 Jan 30.

Department of Dermatology, Brigham and Women's Hospital, Mohs and Dermatologic Surgery Center, Harvard Medical School, 1153 Centre Street, Suite 4J, Boston, MA, 02130, USA.

As Mohs micrographic surgery (MMS) is more widely utilized for melanoma in situ (MIS) and lentigo maligna (LM), there is increasing concern over whether the procedure can negatively affect the treatment of upstaged tumors. Previous studies have shown that about 1-2% of MIS/LM treated with MMS require sentinel lymph node biopsy, but little is still known regarding surgical outcomes. We performed a retrospective chart review of 117 MIS/LM lesions treated with MMS at Brigham and Women's Hospital. Read More

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http://dx.doi.org/10.1007/s00403-020-02034-9DOI Listing
January 2020

Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma.

Am J Dermatopathol 2020 Jan 14. Epub 2020 Jan 14.

Department of Dermatology, Netherlands Institute for Pigment Disorders, Amsterdam UMC, Amsterdam Infection & Immunity Institute, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

The cancer/testis antigens (CTA) are a group of antigens expressed on germ cells of healthy testis and malignant tumors. We studied whether CTA are present on lentigo maligna (LM) and LM melanoma (LMM) samples. Immunohistochemical expression of a panel of CTA (MAGE-A1, A2- A3, NY-ESO-1, PRAME, SSX-2, and a MAGE-A antibody reactive with -A1, -A2, -A3, -A4, -A6, -A10, and -A12) was investigated in formalin-fixed paraffin-embedded samples from LMM (n = 20), LM (n = 8), chronically sun-exposed skin (n = 7), and healthy skin (n = 7). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001607DOI Listing
January 2020

Melanoma recognition by a deep learning convolutional neural network-Performance in different melanoma subtypes and localisations.

Eur J Cancer 2020 Mar 20;127:21-29. Epub 2020 Jan 20.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Deep learning convolutional neural networks (CNNs) show great potential for melanoma diagnosis. Melanoma thickness at diagnosis among others depends on melanoma localisation and subtype (e.g. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.11.020DOI Listing

Commentary on: Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars.

J Eur Acad Dermatol Venereol 2020 01;34(1):13

Service de Dermatologie, Hôpital Universitaire de Saint-Etienne, St. Etienne, France.

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http://dx.doi.org/10.1111/jdv.16046DOI Listing
January 2020

Defining Surgical Margins With Wood Lamp.

Dermatol Pract Concept 2020 31;10(1):e2020018. Epub 2019 Dec 31.

Department of Dermatology, University Hospital of Wales, Cardiff, UK.

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http://dx.doi.org/10.5826/dpc.1001a18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936641PMC
December 2019

Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines.

Anticancer Res 2020 Jan;40(1):557-564

Department of Dermatology, Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background/aim: Ultraviolet radiation (UVR) causes solar lentigines (SL) and skin cancer (SC) in humans. The association between measured lifetime UVR dose and SC has not been investigated. This study investigated this relation through their common relationship to SL. Read More

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http://dx.doi.org/10.21873/anticanres.13985DOI Listing
January 2020

Anti-melanogenic activity of salacinol by inhibition of tyrosinase oligosaccharide processing.

J Biochem 2020 May;167(5):503-511

Pharmaceutical & Healthcare Research Laboratories, FUJIFILM Inc., 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa 258-8577, Japan.

Hyperpigmentation that manifests through melasma and solar lentigo (age spots), although mostly harmless for health, bothers many people. Controlling the rate-limiting activity of tyrosinase is most effective for suppressing excessive melanin formation and accordingly recent research has focused on the maturation of tyrosinase. Salacia, a medicinal plant, has been used to treat diabetes in India and Sri Lanka. Read More

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http://dx.doi.org/10.1093/jb/mvz115DOI Listing

The anatomic distribution of cutaneous melanoma: A detailed study of 5141 lesions.

Australas J Dermatol 2020 May 27;61(2):125-133. Epub 2019 Dec 27.

Victorian Melanoma Service, Alfred Health, Melbourne, Victoria, Australia.

Background/objectives: There is evidence that cutaneous melanomas at different anatomic sites present with distinctive clinicopathologic features. We examined the anatomic distribution of cutaneous melanoma and its variation by patient characteristics, subtype and Breslow thickness, using high-resolution anatomic site data.

Methods: A cross-sectional study was performed of all primary cutaneous melanoma cases managed at a tertiary referral centre, analysing prospectively collected clinical data across 50 anatomic subsites. Read More

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http://dx.doi.org/10.1111/ajd.13223DOI Listing

[Peutz-Jeghers syndrome and cancer:a retrospective study in 14 Japanese patients with Peutz-Jeghers syndrome].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(12):1015-1021

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

We retrospectively investigated 14 Japanese patients with Peutz-Jeghers (PJ) syndrome who were treated in six hospitals to determine the prevalence of cancer in Japanese patients with PJ syndrome. The study included seven males and seven females. The mean age at the time of diagnosis of PJ syndrome was 28. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.1015DOI Listing
December 2019

Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study.

J Am Acad Dermatol 2019 Dec 5. Epub 2019 Dec 5.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Lentigo maligna/lentigo maligna melanoma (LM/LMM) can present with subclinical extension that may be difficult to define preoperatively and lead to incomplete excision and potential recurrence. Preliminarily studies have used reflectance confocal microscopy (RCM) to assess LM/LMM margins.

Objective: To evaluate the correlation of LM/LMM subclinical extension defined by RCM compared to the gold standard histopathology. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.11.058DOI Listing
December 2019

A meta-analysis comparing confocal microscopy and dermoscopy in diagnostic accuracy of lentigo maligna.

Skin Res Technol 2019 Dec 6. Epub 2019 Dec 6.

Department of Dermatology, Chinese PLA General Hospital, Beijing, China.

Purpose: We aimed to summarize the sensitivity and specificity between RCM and dermoscopy in LM diagnosis.

Methods: A meta-analysis was conducted to the study. PubMed, Google Scholar, Cochrane Library, and Wiley Online Library database were searched for relevant studies. Read More

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http://dx.doi.org/10.1111/srt.12821DOI Listing
December 2019

Peutz-Jeghers syndrome complicated with intussusception in late pregnancy.

Lancet Oncol 2019 12;20(12):e729

Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

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http://dx.doi.org/10.1016/S1470-2045(19)30692-8DOI Listing
December 2019

[Diagnostics and treatment of lentigo maligna melanoma in Denmark].

Ugeskr Laeger 2019 Oct;181(44)

The incidence of maligna melanoma has doubled in Denmark over the latest 30 years. Lentigo maligna melanomas (LMM) account for 10-26% of the melanomas in head and neck. LMM most often strike people over the age of 70 years and frequently occur in sun-exposed skin areas. Read More

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October 2019

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).

Gut 2020 03 28;69(3):411-444. Epub 2019 Nov 28.

Genetic Medicine, Central Manchester University Hospitals Foundation Trust, Manchester, UK.

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. Read More

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http://dx.doi.org/10.1136/gutjnl-2019-319915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034349PMC

PIGMENTED MACULES REMOVAL WITH COSMETIC TREATMENT MAY COVER UP PEUTZ-JEGHERS SYNDROME: A CASE REPORT.

Gastroenterol Nurs 2019 Nov/Dec;42(6):504-507

Feihong Ji, MD, Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. Chenyu Sun, MD, MSc, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China Province. Feras Kamel Rizeq, MPH, The Avalon University School of Medicine, Santa Rosaweg, Willemstad, Curaçao. Minglong Pu, MD, Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. Hongwei Yang, PhD, MD, Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. Xinhua Dong, MD, Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. Zhengyang Wang, PhD, MD, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. Weilong Chang, PhD, MD, Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. Zhen Yang, MD, is Associate Professor and Associate Chief Physician, Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

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http://dx.doi.org/10.1097/SGA.0000000000000449DOI Listing
June 2020
0.561 Impact Factor

Repigmentation of gray hairs with lentigo maligna and response to topical imiquimod.

JAAD Case Rep 2019 Dec 13;5(12):1015-1017. Epub 2019 Nov 13.

Cutaneous Oncology Division, Scully-Welsh Cancer Center, Cleveland Clinic Indian River Hospital, Vero Beach, Florida.

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http://dx.doi.org/10.1016/j.jdcr.2019.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864298PMC
December 2019

Dermoscopic-Histopathological Correlation of Eccrine Poroma: An Observational Study.

Dermatol Pract Concept 2019 Oct 31;9(4):283-291. Epub 2019 Oct 31.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

Background: Eccrine poroma (EP) is a benign adnexal neoplasm that can be pigmented in 17% of cases. Four histopathological variants of EP exist. Dermoscopically, EP can mimic many other skin neoplasms. Read More

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http://dx.doi.org/10.5826/dpc.0904a07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830555PMC
October 2019

Neck Melanoma: Clinical, Dermoscopic and Confocal Features.

Dermatology 2020 8;236(3):241-247. Epub 2019 Nov 8.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: The head and neck are considered one single anatomical unit. No data on clinical, dermoscopic and confocal aspects of neck melanoma are currently available.

Objectives: To identify clinical, dermoscopic and confocal diagnostic features of neck melanomas. Read More

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http://dx.doi.org/10.1159/000503284DOI Listing
November 2019