4,732 results match your criteria Lentigo

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).

Jpn J Clin Oncol 2021 Jun 12. Epub 2021 Jun 12.

Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

Background: Nivolumab, the anti-programmed cell death protein 1 antibody, has been approved for advanced melanoma, mainly based on evidence from Western countries. The profile of melanoma differs between Caucasian and Asian patients. This study was performed to obtain post-marketing data of nivolumab in Japanese patients with advanced melanoma. Read More

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Mucocutaneous manifestations of patients with chronic kidney disease under hemodialysis: A cross-sectional study of 49 patients.

Dermatol Ther 2021 Jun 2:e15015. Epub 2021 Jun 2.

Pediatric Department, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Chronic Kidney Disease (CKD) is a common medical problem with well-known dermatologic manifestations, some of which highly disturb the patients' quality of life. This cross-sectional study was designed to identify the prevalence and type of cutaneous involvement in CKD patients. The skin manifestations of 49 patients with CKD undergoing hemodialysis at Akhavan Hospital in Kashan, Iran, were recorded over two months. Read More

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Citral-Containing Essential Oils as Potential Tyrosinase Inhibitors: A Bio-Guided Fractionation Approach.

Plants (Basel) 2021 May 13;10(5). Epub 2021 May 13.

Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, I-10125 Turin, Italy.

Excessive melanin production causes serious dermatological conditions as well as minor aesthetic problems (i.e., freckles and solar lentigo). Read More

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Melanoma In Situ: A Critical Review and Re-Evaluation of Current Excision Margin Recommendations.

Adv Ther 2021 May 28. Epub 2021 May 28.

Melanoma Institute Australia, The University of Sydney, 40 Rocklands Road, North Sydney, NSW, 2060, Australia.

Most international clinical guidelines recommend 5-10 mm clinical margins for excision of melanoma in situ (MIS). While the evidence supporting this is weak, these guidelines are generally consistent. However, as a result of the high incidence of subclinical extension of MIS, especially of the lentigo maligna (LM) subtype, wider margins will often be needed to achieve complete histologic clearance. Read More

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Risk factors for cardiovascular mortality and melanoma-specific mortality among patients with melanoma: a SEER based study.

Eur J Cancer Prev 2021 May 18. Epub 2021 May 18.

Faculty of Medicine, Alexandria University, Alexandria Faculty of Medicine, Al-Azhar University, Assiut Faculty of Medicine, Fayoum University, Fayoum Faculty of Medicine, Assiut University, Assiut, Egypt.

Objective: This study aims to identify the risk factors for cardiovascular mortality in melanoma patients.

Methods: Data of melanoma patients were obtained from the Surveillance, Epidemiology, and End Results database. We used Person's chi-square test to assess the relationships between categorical variables. Read More

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Lentigo maligna: defining margins and predictors of recurrence utilising clinical, dermoscopic, confocal microscopy and histopathology features.

J Eur Acad Dermatol Venereol 2021 May 17. Epub 2021 May 17.

Melanoma Institute Australia (MIA), The University of Sydney, North Sydney, Australia.

Background: Lentigo maligna (LM) is a subtype of melanoma in situ with poorly defined margins and a high recurrence rate. The biological behaviour of LM appears to differ widely between cases, from biologically indolent to biologically active variants, with some patients experiencing multiple recurrences. It is not known whether this is secondary to inadequate margins, field cancerisation or the innate biology of the lesion itself. Read More

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Histopathologic classification and prognostic factors of melanoma: a 2020 update.

Mattheos Bobos

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Department of Biomedical Sciences, School of Health Sciences, Alexandrian Campus, International Hellenic University, Thessaloniki, Greece -

Despite the rapid recent advances in molecular analysis of tumors, which allow large-scale and high-resolution genomics, the "gold standard" for melanoma diagnosis continues to be histopathology, in conjunction with clinical characteristics and sometimes with important support of immunohistochemistry. Observations, where postulated that cutaneous melanomas may arise through two distinct pathways, discoveries such as that BRAFV600E mutations were mostly common in melanomas on sun-exposed skin with little solar elastosis and seminal works for melanoma progression and evolution set the groundwork for the new WHO Classification of Melanoma; a classification of melanoma that not only encompasses histologic but also clinical, epidemiologic, and genetic characteristics. The melanomas were divided into those etiologically related to sun exposure and those that are not, based on their mutational signatures, anatomic site, and epidemiology. Read More

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Effect of reflectance confocal microscopy compared to dermoscopy in the diagnostic accuracy of lentigo maligna: A meta-analysis.

Int J Clin Pract 2021 May 11:e14346. Epub 2021 May 11.

Department of Dermatology, Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin, China.

Introduction: Many concerns were raised about the sensitivity and specificity outcome of reflectance confocal microscopy compared to dermoscopy for the diagnosis of lentigo maligna. However, the reported relationships between their sensitivity and specificity were variable. Our meta-analysis was performed to clarify this relationship. Read More

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Systematic review and meta-analysis of local recurrence rates of head and neck cutaneous melanomas after wide local excision, Mohs micrographic surgery, or staged excision.

J Am Acad Dermatol 2021 May 4. Epub 2021 May 4.

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Prospective trials have not compared the local recurrence rates of different excision techniques for cutaneous melanomas on the head and neck.

Objective: To determine local recurrence rates of cutaneous head and neck melanoma after wide local excision (WLE), Mohs micrographic surgery (MMS), or staged excision.

Methods: A systematic review of PubMed, EMBASE, and Web of Science identified all English case series, cohort studies, and randomized controlled trials that reported local recurrence rates after surgery for cutaneous head and neck melanoma. Read More

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Hydrochlorothiazide and risk of melanoma subtypes.

Pharmacoepidemiol Drug Saf 2021 May 7. Epub 2021 May 7.

Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Background: Hydrochlorothiazide (HCTZ), a common diuretic known to be photosensitizing and previously associated with non-melanoma skin cancer, was recently reported to be associated with two melanoma subtypes, nodular and lentigo, among residents of Denmark. Our goal was to examine whether Danish findings could be replicated in a US cohort, using a similar study design and analysis.

Methods: Among non-Hispanic White enrollees of Kaiser Permanente Northern California, we conducted an analysis of 9176 melanoma cases and 264 781 controls, matched on age, sex and time in health plan. Read More

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Flat scalp melanoma dermoscopic and reflectance confocal microscopy features correspond to histopathologic type and lesion location.

J Eur Acad Dermatol Venereol 2021 May 7. Epub 2021 May 7.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Background: Dermoscopy and Reflectance Confocal Microscopy (RCM) features of scalp melanoma according to lesion location and histopathology have not been fully investigated.

Objectives: To reveal dermoscopic and RCM features of scalp melanoma according to lesion location and histopathology.

Methods: We retrospectively retrieved images of suspicious, atypical excised, flat melanocytic lesions of the scalp, assessed on dermoscopy and RCM at five centres, from June 2007 to April 2020. Read More

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Inhibition of β-Catenin Activity Abolishes LKB1 Loss-Driven Pancreatic Cystadenoma in Mice.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

Pancreatic cancer (PC) is the seventh leading cause of cancer death worldwide, and remains one of our most recalcitrant and dismal diseases. In contrast to many other malignancies, there has not been a significant improvement in patient survival over the past decade. Despite advances in our understanding of the genetic alterations associated with this disease, an incomplete understanding of the underlying biology and lack of suitable animal models have hampered efforts to develop more effective therapies. Read More

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3'UTR-CDKN2A and CDK4 Germline Variants Are Associated With Susceptibility to Cutaneous Melanoma.

In Vivo 2021 May-Jun;35(3):1529-1536

General Dermatology Group, Hospital Universitario Centro Dermatológico Federico Lleras Acosta E.S.E, Bogotá, Colombia

Background/aim: Genetic variations of the CDKN2A and CDK4 gene have been associated to melanoma development. In the present study we investigated the potential associations of CDKN2A and CDK4 gene variants in a colombian population diagnosed with melanoma.

Materials And Methods: DNA was extracted from whole blood samples from 85 patients diagnosed with cutaneous melanoma and 166 healthy controls. Read More

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January 2021

Three-dimensional histological explanation of the dermoscopy patterns in acral melanocytic lesions.

J Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Dermoscopic images of pigmented lesions have distinct features on the sole where skin ridges and furrows exist. Pigmentation of benign nevus usually locates on the skin furrow, while the malignant melanoma is pigmented on the skin ridge. Correspondence between dermoscopy and pathology in the pigmented lesions on soles have been studied based on conventional vertical pathological images. Read More

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Real-world experience on off-label use of imiquimod 5% as an adjuvant therapy after surgery or as a monotherapy for lentigo maligna.

Br J Dermatol 2021 Apr 24. Epub 2021 Apr 24.

Dermatology Unit, University of Campania, Naples, Italy.

Because of the tendency of lentigo maligna (LM) for subclinical extension, staged excisions with margin control achieve lower recurrence rates than conventional wide local excision (0-9.5% vs 8-20%). However, these surgical techniques are limited by their requirement in time, costs and training. Read More

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Desmoplastic Melanoma: A Clinicopathological Analysis of Three Cases in the Chinese Population.

Onco Targets Ther 2021 15;14:2651-2660. Epub 2021 Apr 15.

Department of Pathology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200050, People's Republic of China.

Purpose: To investigate the clinicopathological characteristics and immunophenotype of desmoplastic melanoma (DM) in the Chinese population.

Patients And Methods: We report three cases of DM diagnosed by the Pathology Department of Shanghai Dermatology Hospital. We describe the clinical and pathological characteristics of the three cases and examine molecular markers used in the diagnosis of DM. Read More

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Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study.

BMC Cancer 2021 Apr 16;21(1):420. Epub 2021 Apr 16.

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, No. 88, Jiefang Road, Hangzhou, 310009, China.

Background: Previous studies reported cutaneous melanoma in head and neck (HNM) differed from those in other regions (body melanoma, BM). Individualized tools to predict the survival of patients with HNM or BM remain insufficient. We aimed at comparing the characteristics of HNM and BM, developing and validating nomograms for predicting the survival of patients with HNM or BM. Read More

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Recurrent lentigo maligna in a young patient.

Ital J Dermatol Venerol 2021 Feb;156(1):89-91

Dermatopathological Laboratory, San Gallicano Dermatology Institute, Rome, Italy.

Lentigo maligna (LM) is usually diagnosed in sun-damaged skin of elderly patients and a correct excision of the lesion determines a complete healing from the disease. LM is very rare in young patients and, for this reason, it can be commonly misdiagnosed. We describe the case of a locally recurrent LM in a 19-year-old male patient, which initially arose at the age of 17 years. Read More

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February 2021

Vascular morphology in facial solar lentigo assessed by optical coherence tomography angiography.

J Dermatol Sci 2021 Apr 3. Epub 2021 Apr 3.

Research Institute of Psoriasis, Kojinkai Association of Medical Corporation, Sapporo, Japan.

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Mohs Surgery Outside Usual Indications: A Review.

Acta Dermatovenerol Croat 2020 Dec;28(7):210-214

Pedro Rodríguez-Jiménez, MD, Dermatology Department, Hospital Universitario de la Princesa, Madrid, Calle Diego de Leon 62, 28006 Madrid, Spain;

The body of literature supporting the use of Mohs micrographic surgery (MMS) in tumors outside the main indications (basal cell carcinoma, squamous cell carcinoma, dermatofibrosacroma protuberans, lentigo maligna) is constantly growing, but it is still based on case reports, case series, or at best institutional case series that focus on a single malignancy. Our aim in this review was to assess use of MMS in an array of rare tumors outside the usual indications. A review was performed using the MEDLINE database and the search engine ClinicalKey®. Read More

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December 2020

Intestinal obstruction with oral pigmentation: a clue to Peutz-Jeghers syndrome.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

General Surgery, All India Institute of Medical Sciences, Bhubaneswar, India.

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder, which manifests as mucocutaneous hyperpigmentation and, intestinal and extraintestinal polyps. The classic triad of abdominal pain, mass and jam-like stools are not found commonly. On clinical examination, a strong suspicion of PJS should be made if patients below 18 years, present with mucocutaneous hyperpigmentation and intestinal obstruction. Read More

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Dealing with lentigo maligna: A challenging case.

Aust J Gen Pract 2021 04;50(4):222-224

MBBS, FACD, Consultant Dermatologist, Mater Hospital, Qld; Associate Professor, University of Queensland, Qld.

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Change in lentigo maligna score assessed by in vivo reflectance confocal microscopy after one month of imiquimod treatment for lentigo maligna management.

J Am Acad Dermatol 2021 Mar 27. Epub 2021 Mar 27.

Nantes University, Department of Dermatology, CHU Nantes, CIC 1413, CRCINA, Nantes university F-44000 Nantes, France. Electronic address:

Background: Treatment of Lentigo Maligna (LM) is challenging because of the potential functional and esthetic surgical sequelae. Imiquimod has been proposed as an alternative treatment for LM. Reflectance Confocal Microscopy (RCM) is a non-invasive tool used for the diagnosis of LM and margin assessment. Read More

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Unusual Morphological Presentation of Cutaneous Malignant Melanoma: A Rare Case Report.

Indian Dermatol Online J 2021 Jan-Feb;12(1):139-141. Epub 2021 Jan 16.

Department of Pathology, Prolife Diagnostics, Bhubaneswar, Odisha, India.

Cutaneous malignant melanoma is a rapidly progressing skin tumor accounting for most deaths from skin malignancies. Four morphological variants (nodular, superficial spreading, lentigo maligna, and acral lentiginous) are described in the literature. Here we are reporting malignant melanoma in a 35-year-old male who presented with depigmented plaques with few hyperpigmented areas and extensive overlying scaling. Read More

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January 2021

Dermoscopy of a Lentigo Maligna Less Than 1.5 mm in Diameter.

Karim Saleh

Dermatol Pract Concept 2021 Mar 8;11(2):e2021027. Epub 2021 Mar 8.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.

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Non-Peutz-Jeghers syndrome-associated ovarian sex cord tumor with annular tubules treated by radiotherapy: a case report and literature review.

J Int Med Res 2021 Mar;49(3):300060521996563

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.

There are no standard treatment options for metastatic and recurrent non-Peutz-Jeghers syndrome (PJS)-associated sex cord tumor with annular tubules (SCTAT). The effects of chemotherapy and/or radiotherapy are still not well-defined. Herein, we present a case of a metastatic and recurrent non-PJS-associated SCTAT showing high serum estradiol and progesterone concentrations after surgery and chemotherapy. Read More

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Appendiceal intussusception secondary to hamartomatous polyps of Peutz-Jegher syndrome.

ANZ J Surg 2020 10;90(10):2144-2145

Department of Colorectal Surgery, Royal North Shore Hospital, Sydney, New South Wales, Australia.

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October 2020