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    Handheld reflectance confocal microscopy to aid in the management of complex facial lentigo maligna.
    Cutis 2017 May;99(5):346-352
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, and Department of Dermatology, Weill Cornell Medical College, New York, USA.
    Diagnosis and management of lentigo maligna (LM) and LM melanoma (LMM) is challenging. Novel noninvasive imaging technologies such as reflectance confocal microscopy (RCM) have advanced the ability to better diagnose and monitor challenging lesions. In addition, the new handheld RCM (HRCM) together with the use of videomosaics has allowed an accurate evaluation of large lesions in concave/convex areas of the body (eg, the face). Read More

    Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib.
    J Drugs Dermatol 2017 May;16(5):508-511

    The Food and Drug Administration approved Ruxolitinib in 2011 for the treatment of primary myelofibrosis. Five-year safety data showed a higher incidence of skin cancer in patients treated with Ruxolitinib compared to best available therapy for myelofibrosis. This report presents a series of five patients with history of myelofibrosis treated with Ruxolitinib who subsequently developed numerous skin cancers with aggressive biological behavior. Read More


    [Overlap syndrome. LEOPARD and neurofibromatosis. A case report].
    Rev Med Inst Mex Seguro Soc 2017 Jul-Aug;55(4):540-543
    Servicio de Terapia Intensiva, Hospital General de Zona 30 "Iztacalco", Instituto Mexicano del Seguro Social, Ciudad de México, México.
    We expose a clinical case of a 43-year-old patient who was attended at the Dermatology service in a general hospital of the Instituto Mexicano del Seguro Social, with a disseminated pattern of lentigines, psychomotor retardation and electrocardiographic abnormalities. Afterwards, we made an analysis of the literature. Read More

    Lentigo maligna of the face: A quantitative simple method to identify individual patient risk probability on dermoscopy.
    Australas J Dermatol 2017 Jun 7. Epub 2017 Jun 7.
    Department of Oncological and Preventative Dermatological, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
    Background/objectives: The clinical and dermoscopic differential diagnosis of flat pigmented facial lesions represents a great challenge for the clinicians. Our aim was to report a quantitative method based on dermoscopic features to better classify pigmented facial lesions.

    Methods: This is a retrospective case-series study that analysed the dermoscopic features of 582 pigmented facial lesions. Read More

    Histopathologic and Immunohistochemical Correlates of Confocal Descriptors in Pigmented Facial Macules on Photodamaged Skin.
    JAMA Dermatol 2017 May 31. Epub 2017 May 31.
    Department of Dermatology, Hospital del Mar-Parc de Salut Mar, Univesitat Autònoma de Barcelona, Barcelona, Spain2Institut Mar d'Investigacions Mèdiques, Barcelona, Spain.
    Importance: Pigmented facial macules on photodamaged skin are a clinical, dermoscopic, and histopathologic challenge.

    Objectives: To clinically and dermoscopically characterize, by means of reflectance confocal microscopy (RCM), ambiguous pigmented facial macules and establish a correlation between RCM, histopathologic, and immunohistochemical findings.

    Design, Setting, And Participants: A prospective study of ambiguous pigmented facial macules on photodamaged skin was conducted in a tertiary referral center for dermatology between January 1, 2009, and December 31, 2015. Read More

    Lentigo maligna melanoma with a history of cosmetic treatment: Prevalence, surgical outcomes and considerations.
    Lasers Surg Med 2017 May 29. Epub 2017 May 29.
    Memorial Sloan Kettering Cancer Center, Dermatology Service, 16 E. 60th Street, 4th Floor Dermatology, New York, New York, 10022.
    Introduction: Lentigo maligna (LM) is melanoma in situ on sun-damaged skin and presents diagnostic challenges due to overlapping features with benign pigmented lesions. Cosmetic treatments may be inadvertently performed on LM. The aim of this study is to estimate the prevalence of LM with prior cosmetic treatment, and evaluate surgical outcomes. Read More

    Longitudinal melanonychia in childhood: a clinical and histopathological review of Korean patients.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
    Longitudinal melanonychia is not frequently observed in children, and few studies exist on longitudinal melanonychia in paediatric patients, especially in Asian populations. We aimed to evaluate the clinical and histological findings of longitudinal melanonychia in Korean paediatric patients. A retrospective review of paediatric patients (≤18 years old) with longitudinal melanonychia who underwent nail biopsy between January 2010 and October 2015 was performed. Read More

    Peutz-Jeghers syndrome with intermittent upper intestinal obstruction: A case report and review of the literature.
    Medicine (Baltimore) 2017 Apr;96(17):e6538
    aDepartment of Pediatric Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China bDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic syndrome characterized by a unique type of gastrointestinal hamartomatous polyp associated with oral and anal mucocutaneous pigmentations. Peutz-Jeghers polyps occur most numerously in the small intestine but frequently in the colon and stomach, only a few cases have been reported in the duodenum.

    Patient Concern: A further family history survey discovered 10 out of 14 members of the family (in 4 generations) had mucocutaneous pigmentations, but many of them were living in rural areas where they had no access to specialized medical services, so none were checked with endoscopy for polyps of hamartoma. Read More

    Topography of Protein Kinase C βII in Benign and Malignant Melanocytic Lesions.
    Int J Surg Pathol 2017 Apr 1:1066896917706026. Epub 2017 Apr 1.
    2 Laboratory of Pathology, Division of Morphology, University of Crete, Heraklion, Greece.
    Background: Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro.

    Objective: To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations.

    Methods: Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry. Read More

    Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules.
    Dermatol Surg 2017 Jul;43(7):911-919
    *Department of Dermatology, Paracelsus Medical University of Salzburg, Salzburg, Austria; †Department of Dermatology, Medical University of Graz, Graz, Austria, Europe.
    Background: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.

    Objective: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.

    Patients And Methods: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together. Read More

    Malignant Melanoma in African-Americans: A Population-Based Clinical Outcomes Study Involving 1106 African-American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988-2011).
    Medicine (Baltimore) 2017 Apr;96(15):e6258
    aDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ bSaint George's University School of Medicine, Grenada, West Indies cDepartment of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ dDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ.
    Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Read More

    Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
    Biol Pharm Bull 2017 ;40(4):535-539
    Amorepacific R&D Corporation Center.
    Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated. Read More

    Tumoral Melanosis Associated with Pembrolizumab-Treated Metastatic Melanoma.
    Cureus 2017 Feb 13;9(2):e1026. Epub 2017 Feb 13.
    Department of Dermatology, University of California, San Diego.
    Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. Read More

    Reconstruction of Combined Upper and Lower Eyelid Defects in a Patient With Lentigo Maligna.
    Dermatol Surg 2017 May;43 Suppl 1:S111-S114
    *Department of Ophthalmology, Hospital de l´Espearnça, Parc de Salut Mar, Barcelona, Spain; †Department of Dermatology, Hospital Universitario de Donostia, San Sebastian, Spain; and ‡Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.

    Correlation between digital epiluminescence microscopy parameters and histopathological changes in lentigo maligna and solar lentigo: A dermoscopic index for the diagnosis of lentigo maligna.
    J Am Acad Dermatol 2017 Feb 26;76(2):234-243. Epub 2016 Oct 26.
    Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Luigi Maria Monti (IRCCS-FLMM), Rome, Italy.
    Background: The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult.

    Objective: Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new model of LM dermoscopic progression based on a study of DELM-histopathological correlation.

    Methods: A total of 167 consecutive doubtful pigmented lesions of the head (105 LM and 62 SL/SK) were studied. Read More

    The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    Departments of *Dermatology, and †Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
    Background: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.

    Objective: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo.

    Materials And Methods: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. Read More

    Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery.
    Dermatol Surg 2017 Jun;43(6):792-797
    *Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Various studies have reported local recurrence (LR) rates after surgical treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM). However, the time to LR of LM/LMM is not currently known, as few studies report time to LR and have long-term follow-up.

    Objective: To define time to LR in LM/LMM after surgical treatment, and to describe features of observed LR. Read More

    Characteristic features of cutaneous melanoma in a dermatology referral centre in Tehran, Iran.
    Australas J Dermatol 2017 Mar 15. Epub 2017 Mar 15.
    Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background/objectives: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran.

    Methods: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Read More

    A novel mutation in the STK11 gene causes heritable Peutz-Jeghers syndrome - a case report.
    BMC Med Genet 2017 Feb 23;18(1):19. Epub 2017 Feb 23.
    Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, No. 74 Zhongshan 2 Road, Guangzhou, 510080, China.
    Background: Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. STK11 has been identified as a causative gene for this disease.

    Case Presentation: Herein we report a Chinese Han kindred with PJS. Read More

    Diagnosis and management of lentigo maligna: an observational study comparing 2005 with 2014 data in one institution.
    Clin Exp Dermatol 2017 Apr 22;42(3):320-323. Epub 2017 Feb 22.
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
    The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. Read More

    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Apr 20;42(3):266-275. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Differential morphological and functional features of fibroblasts explanted from Solar Lentigo.
    Br J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    UMR U978 INSERM, Bobigny Cedex, France.
    Upon ageing, chronic exposure to ultraviolet radiations and pollution induces benign hyper-pigmented lesions, such as Solar Lentigo maculae (SL) (1) . Well-defined histologically, SL is distinguishable from other hyper-pigmented diseases and can be classified relative to its evolution (2-4) . Differential gene-profiling analyses comparing SL and normal skin biopsies revealed that SL tissues are mainly composed of epidermal activated melanocytes as well as hypo-proliferating and hypo-differentiated keratinocytes with a background of chronic inflammation. Read More

    Patient and medical barriers preclude uptake of tamoxifen preventative therapy in women with a strong family history.
    Breast 2017 Apr 18;32:93-97. Epub 2017 Jan 18.
    Breast Tumor Stream, Victorian Comprehensive Cancer Centre, Australia; Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, Australia; Familial Cancer Centre, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Australia.
    Aims: To assess the eligibility, uptake and impediments to tamoxifen use in high-risk women attending a risk management clinic due to family history.

    Patients And Methods: All patients with a germline mutation in a cancer predisposing gene or at high genetic risk (based on family history) attending a Breast and Ovarian cancer risk management clinic from February 2014 to May 2015 received both verbal and written evidence-based information on preventive therapy and were recommended to consider endocrine prevention if not contraindicated. Endocrine therapy initiation, use and cessation were captured. Read More

    Chondrosarcomatous Differentiation in a Large Malignant Melanoma of the Scalp.
    Case Rep Med 2016 18;2016:1063569. Epub 2016 Dec 18.
    Castle Hill Hospital, East Yorkshire, UK.
    Background. Divergent differentiation in malignant melanoma is a rare phenomenon, which can lead to delayed diagnosis or misdiagnosis, impacting upon patient treatment and outcome, as well as the understanding of tumour behaviour. Case. Read More

    Dermatoscopy-guided therapy of pigmented basal cell carcinoma with imiquimod.
    An Bras Dermatol 2016 Nov-Dec;91(6):764-769
    San Cecilio University Hospital - Granada, Spain.
    Background:: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod.

    Objective:: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Apr 7;76(4):707-713. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland.
    Invasive lentigo maligna melanoma (LMM) and its in situ precursor lentigo maligna (LM) are the most common melanoma types on the head and neck areas (1) . Clinically unsuspected invasion is revealed histologically in 5-52% of LMs (2) . Thus, correct early diagnoses are crucial for determining accurate resection margins and the discussion of sentinel lymph node examination (3) . Read More

    A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures.
    J Eur Acad Dermatol Venereol 2017 Apr 23;31(4):616-624. Epub 2017 Jan 23.
    Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Read More

    Incidence trends and clinical-pathological characteristics of invasive cutaneous melanoma from 1980 to 2010 in the Canton of Zurich, Switzerland.
    Melanoma Res 2017 Apr;27(2):145-151
    aDivision of Cancer Epidemiology and Prevention, Epidemiology, Biostatistics and Prevention Institute bCancer Registry Zurich and Zug cDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Read More

    Follicular Malignant Melanoma: A Rare Morphologic Variant of Melanoma. Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 May;39(5):e69-e70
    *Department of Dermatology, University of Illinois at Chicago, Chicago, IL; †Advanced Dermatology and Mohs Surgery, Batavia, IL; and ‡Consolidated Pathology Consultants, Libertyville, IL.
    Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Read More

    Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma.
    Br J Cancer 2017 Jan 29;116(2):253-259. Epub 2016 Nov 29.
    Institute for Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
    Background: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme.

    Methods: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Data from 350 306 SCREEN participants, who had been screened negative for melanoma, were linked to data of the state cancer registry. Read More

    University Hospital Waterford: 5-year experience of cutaneous melanoma.
    Ir J Med Sci 2017 May 21;186(2):309-314. Epub 2016 Nov 21.
    Department of Breast and Endocrine Surgery, University Hospital Waterford, Waterford, Ireland.
    Introduction: The incidence of cutaneous melanoma (CM) continues to rise in Ireland. Despite significant advances in melanoma molecular therapy, surgery remains the mainstay of treatment for CM. The University Hospital Waterford (UHW) prospectively maintained CM registry was established in 2010. Read More

    Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
    Acta Derm Venereol 2017 Apr;97(4):483-488
    Department of Dermatology, Nantes University Hospital, INSERM, 892, FR-44000 Nantes, France.
    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of indoleamine 2,3-dioxygenase (IDO), PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. Read More

    Three novel mutations of STK11 gene in Chinese patients with Peutz-Jeghers syndrome.
    BMC Med Genet 2016 Nov 8;17(1):77. Epub 2016 Nov 8.
    The State Key Laboratory of Medical Genetics, Central South University, 110 Xiangya Road, Changsha, Hunan, 410078, China.
    Background: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disorder characterized by gastrointestinal (GI) hamartomatous polyps, mucocutaneous hyperpigmentation, and an increased risk of cancer. Mutations in the serine-threonine kinase 11 gene (SKT11) are the major cause of PJS.

    Case Presentation: Blood samples were collected from six PJS families including eight patients. Read More

    Genetics and genomics of ovarian sex cord-stromal tumors.
    Clin Genet 2017 Feb;91(2):285-291
    Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Australia.
    Ovarian sex cord-stromal tumors (SCST) represent approximately 8% of malignant ovarian tumors. The most common are granulosa cell tumors (GCT) which account for approximately 90% of malignant SCST. Recent studies have unraveled the key genomic and genetic events contributing to their pathogenesis. Read More

    Colonisation of basal cell carcinoma by lentigo maligna: a case report, review of the literature, and series follow-up.
    Eur J Dermatol 2016 Oct;26(5):465-469
    Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, CH-1011 Lausanne, Switzerland.
    Background: Melanocytic tumours which colonise basal cell carcinomas (BCC) may be considered as either lentigo maligna (LM) (in situ) or invasive melanomas.

    Objectives: To highlight the diagnostic approach and long-term prognosis of LM which colonises BCC.

    Materials And Methods: Using Satter et al. Read More

    Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey.
    J Dermatolog Treat 2016 Nov 15:1-5. Epub 2016 Nov 15.
    a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Purpose: To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.

    Materials And Methods: The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 patients were enrolled and reviewed for clinical features and factors associated with PIH. Read More

    Molecular screening strategies for NF1-like syndromes with café-au-lait macules (Review).
    Mol Med Rep 2016 Nov 22;14(5):4023-4029. Epub 2016 Sep 22.
    Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China.
    Multiple café-au-lait macules (CALM) are usually associated with neurofibromatosis type 1 (NF1), one of the most common hereditary disorders. However, a group of genetic disorders presenting with CALM have mutations that are involved in human skin pigmentation regulation signaling pathways, including KIT ligand/KIT proto‑oncogene receptor tyrosine kinase and Ras/mitogen‑activated protein kinase. These disorders, which include Legius syndrome, Noonan syndrome with multiple lentigines or LEOPARD syndrome, and familial progressive hyperpigmentation) are difficult to distinguish from NF1 at early stages, using skin appearance alone. Read More

    Prospective, randomized, evaluator-blinded study of the long pulse 532-nm KTP laser alone or in combination with the long pulse 1064-nm Nd: YAG laser on facial rejuvenation in Asian skin.
    Lasers Surg Med 2016 Nov 8;48(9):844-851. Epub 2016 Sep 8.
    Aoyama Institute of Women's Medicine, Tokyo Women's Medical University, Tokyo 107-0061, Japan.
    Background And Objective: Hyperpigmentation is a common concern in Asian patients. Few published studies address overall skin rejuvenation in this group using long-pulse (LP) laser to target pigmentation and stimulate dermal remodeling. The LP KTP 532-nm laser (LP 532-nm) is used primarily to remove epidermal lesions, while the LP Nd: YAG 1064-nm laser (LP 1064-nm) is used to stimulate dermal remodeling in Asian patients with varying efficacy. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

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