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    Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules.
    Dermatol Surg 2017 Apr 19. Epub 2017 Apr 19.
    *Department of Dermatology, Paracelsus Medical University of Salzburg, Salzburg, Austria; †Department of Dermatology, Medical University of Graz, Graz, Austria, Europe.
    Background: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.

    Objective: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.

    Patients And Methods: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together. Read More

    Malignant Melanoma in African-Americans: A Population-Based Clinical Outcomes Study Involving 1106 African-American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988-2011).
    Medicine (Baltimore) 2017 Apr;96(15):e6258
    aDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ bSaint George's University School of Medicine, Grenada, West Indies cDepartment of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ dDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ.
    Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Read More

    Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
    Biol Pharm Bull 2017 ;40(4):535-539
    Amorepacific R&D Corporation Center.
    Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated. Read More

    Imiquimod treatment for lentigo maligna - LIMIT-1 trial.
    Br J Dermatol 2017 Mar 29. Epub 2017 Mar 29.
    Melanoma Institute Australia, Sydney, Australia.
    We read with interest the methods and results of the LIMIT-1 trial regarding primary imiquimod treatment for lentigo maligna (LM) in the journal.(1) We applaud the authors for using histopathology from a resective specimen as the reference standard. This article is protected by copyright. Read More

    Tumoral Melanosis Associated with Pembrolizumab-Treated Metastatic Melanoma.
    Cureus 2017 Feb 13;9(2):e1026. Epub 2017 Feb 13.
    Department of Dermatology, University of California, San Diego.
    Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. Read More

    Reconstruction of Combined Upper and Lower Eyelid Defects in a Patient With Lentigo Maligna.
    Dermatol Surg 2017 Mar 23. Epub 2017 Mar 23.
    *Department of Ophthalmology, Hospital de l´Espearnça, Parc de Salut Mar, Barcelona, Spain; †Department of Dermatology, Hospital Universitario de Donostia, San Sebastian, Spain; and ‡Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.

    Correlation between digital epiluminescence microscopy parameters and histopathological changes in lentigo maligna and solar lentigo: A dermoscopic index for the diagnosis of lentigo maligna.
    J Am Acad Dermatol 2017 Feb 26;76(2):234-243. Epub 2016 Oct 26.
    Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Luigi Maria Monti (IRCCS-FLMM), Rome, Italy.
    Background: The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult.

    Objective: Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new model of LM dermoscopic progression based on a study of DELM-histopathological correlation.

    Methods: A total of 167 consecutive doubtful pigmented lesions of the head (105 LM and 62 SL/SK) were studied. Read More

    The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    Departments of *Dermatology, and †Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
    Background: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.

    Objective: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo.

    Materials And Methods: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. Read More

    Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery.
    Dermatol Surg 2017 Mar 14. Epub 2017 Mar 14.
    *Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Various studies have reported local recurrence (LR) rates after surgical treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM). However, the time to LR of LM/LMM is not currently known, as few studies report time to LR and have long-term follow-up.

    Objective: To define time to LR in LM/LMM after surgical treatment, and to describe features of observed LR. Read More

    Characteristic features of cutaneous melanoma in a dermatology referral centre in Tehran, Iran.
    Australas J Dermatol 2017 Mar 15. Epub 2017 Mar 15.
    Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background/objectives: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran.

    Methods: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Read More

    Diagnosis and management of lentigo maligna: an observational study comparing 2005 with 2014 data in one institution.
    Clin Exp Dermatol 2017 Apr 22;42(3):320-323. Epub 2017 Feb 22.
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
    The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. Read More

    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Apr 20;42(3):266-275. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Differential morphological and functional features of fibroblasts explanted from Solar Lentigo.
    Br J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    UMR U978 INSERM, Bobigny Cedex, France.
    Upon ageing, chronic exposure to ultraviolet radiations and pollution induces benign hyper-pigmented lesions, such as Solar Lentigo maculae (SL) (1) . Well-defined histologically, SL is distinguishable from other hyper-pigmented diseases and can be classified relative to its evolution (2-4) . Differential gene-profiling analyses comparing SL and normal skin biopsies revealed that SL tissues are mainly composed of epidermal activated melanocytes as well as hypo-proliferating and hypo-differentiated keratinocytes with a background of chronic inflammation. Read More

    Patient and medical barriers preclude uptake of tamoxifen preventative therapy in women with a strong family history.
    Breast 2017 Apr 18;32:93-97. Epub 2017 Jan 18.
    Breast Tumor Stream, Victorian Comprehensive Cancer Centre, Australia; Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, Australia; Familial Cancer Centre, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Australia.
    Aims: To assess the eligibility, uptake and impediments to tamoxifen use in high-risk women attending a risk management clinic due to family history.

    Patients And Methods: All patients with a germline mutation in a cancer predisposing gene or at high genetic risk (based on family history) attending a Breast and Ovarian cancer risk management clinic from February 2014 to May 2015 received both verbal and written evidence-based information on preventive therapy and were recommended to consider endocrine prevention if not contraindicated. Endocrine therapy initiation, use and cessation were captured. Read More

    Chondrosarcomatous Differentiation in a Large Malignant Melanoma of the Scalp.
    Case Rep Med 2016 18;2016:1063569. Epub 2016 Dec 18.
    Castle Hill Hospital, East Yorkshire, UK.
    Background. Divergent differentiation in malignant melanoma is a rare phenomenon, which can lead to delayed diagnosis or misdiagnosis, impacting upon patient treatment and outcome, as well as the understanding of tumour behaviour. Case. Read More

    Dermatoscopy-guided therapy of pigmented basal cell carcinoma with imiquimod.
    An Bras Dermatol 2016 Nov-Dec;91(6):764-769
    San Cecilio University Hospital - Granada, Spain.
    Background:: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod.

    Objective:: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Apr 7;76(4):707-713. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland.
    Invasive lentigo maligna melanoma (LMM) and its in situ precursor lentigo maligna (LM) are the most common melanoma types on the head and neck areas (1) . Clinically unsuspected invasion is revealed histologically in 5-52% of LMs (2) . Thus, correct early diagnoses are crucial for determining accurate resection margins and the discussion of sentinel lymph node examination (3) . Read More

    A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures.
    J Eur Acad Dermatol Venereol 2017 Apr 23;31(4):616-624. Epub 2017 Jan 23.
    Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Read More

    Incidence trends and clinical-pathological characteristics of invasive cutaneous melanoma from 1980 to 2010 in the Canton of Zurich, Switzerland.
    Melanoma Res 2017 Apr;27(2):145-151
    aDivision of Cancer Epidemiology and Prevention, Epidemiology, Biostatistics and Prevention Institute bCancer Registry Zurich and Zug cDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Read More

    Follicular Malignant Melanoma: A Rare Morphologic Variant of Melanoma. Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 May;39(5):e69-e70
    *Department of Dermatology, University of Illinois at Chicago, Chicago, IL; †Advanced Dermatology and Mohs Surgery, Batavia, IL; and ‡Consolidated Pathology Consultants, Libertyville, IL.
    Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Read More

    Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma.
    Br J Cancer 2017 Jan 29;116(2):253-259. Epub 2016 Nov 29.
    Institute for Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
    Background: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme.

    Methods: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Data from 350 306 SCREEN participants, who had been screened negative for melanoma, were linked to data of the state cancer registry. Read More

    University Hospital Waterford: 5-year experience of cutaneous melanoma.
    Ir J Med Sci 2016 Nov 21. Epub 2016 Nov 21.
    Department of Breast and Endocrine Surgery, University Hospital Waterford, Waterford, Ireland.
    Introduction: The incidence of cutaneous melanoma (CM) continues to rise in Ireland. Despite significant advances in melanoma molecular therapy, surgery remains the mainstay of treatment for CM. The University Hospital Waterford (UHW) prospectively maintained CM registry was established in 2010. Read More

    Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
    Acta Derm Venereol 2017 Apr;97(4):483-488
    Department of Dermatology, Nantes University Hospital, INSERM, 892, FR-44000 Nantes, France.
    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of indoleamine 2,3-dioxygenase (IDO), PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. Read More

    Colonisation of basal cell carcinoma by lentigo maligna: a case report, review of the literature, and series follow-up.
    Eur J Dermatol 2016 Oct;26(5):465-469
    Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, CH-1011 Lausanne, Switzerland.
    Background: Melanocytic tumours which colonise basal cell carcinomas (BCC) may be considered as either lentigo maligna (LM) (in situ) or invasive melanomas.

    Objectives: To highlight the diagnostic approach and long-term prognosis of LM which colonises BCC.

    Materials And Methods: Using Satter et al. Read More

    Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey.
    J Dermatolog Treat 2016 Nov 15:1-5. Epub 2016 Nov 15.
    a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Purpose: To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.

    Materials And Methods: The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 patients were enrolled and reviewed for clinical features and factors associated with PIH. Read More

    Molecular screening strategies for NF1-like syndromes with café-au-lait macules (Review).
    Mol Med Rep 2016 Nov 22;14(5):4023-4029. Epub 2016 Sep 22.
    Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China.
    Multiple café-au-lait macules (CALM) are usually associated with neurofibromatosis type 1 (NF1), one of the most common hereditary disorders. However, a group of genetic disorders presenting with CALM have mutations that are involved in human skin pigmentation regulation signaling pathways, including KIT ligand/KIT proto‑oncogene receptor tyrosine kinase and Ras/mitogen‑activated protein kinase. These disorders, which include Legius syndrome, Noonan syndrome with multiple lentigines or LEOPARD syndrome, and familial progressive hyperpigmentation) are difficult to distinguish from NF1 at early stages, using skin appearance alone. Read More

    Prospective, randomized, evaluator-blinded study of the long pulse 532-nm KTP laser alone or in combination with the long pulse 1064-nm Nd: YAG laser on facial rejuvenation in Asian skin.
    Lasers Surg Med 2016 Nov 8;48(9):844-851. Epub 2016 Sep 8.
    Aoyama Institute of Women's Medicine, Tokyo Women's Medical University, Tokyo 107-0061, Japan.
    Background And Objective: Hyperpigmentation is a common concern in Asian patients. Few published studies address overall skin rejuvenation in this group using long-pulse (LP) laser to target pigmentation and stimulate dermal remodeling. The LP KTP 532-nm laser (LP 532-nm) is used primarily to remove epidermal lesions, while the LP Nd: YAG 1064-nm laser (LP 1064-nm) is used to stimulate dermal remodeling in Asian patients with varying efficacy. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    The experience of bilateral cochlear implantation in a child with LEOPARD syndrome.
    Int J Pediatr Otorhinolaryngol 2016 Nov 14;90:125-127. Epub 2016 Sep 14.
    Dept of Otolaryngology, Long Island Jewish Medical Center, NY, USA.
    We present a 3-year old boy with Leopard syndrome. His clinical manifestations included a congenital bilateral sensorineural hearing loss. He underwent cochlear implantation on the right side at age 1 year and on the left side at age 1. Read More

    Desmoplastic melanoma: a challenge for the oncologist.
    Future Oncol 2017 Feb 12;13(4):337-345. Epub 2016 Oct 12.
    Department of Diagnostic & Clinical Medicine & Public Health, Clinical Pathology Unit, University of Modena & Reggio Emilia, Modena, Italy.
    Aim: To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM).

    Materials & Methods: Analysis of all DM records from 1991 to 2015.

    Results: The most common location of DMs was the head and neck (69%); median age and follow-up were 60. Read More

    Effect of topical imiquimod as primary treatment for lentigo maligna: the LIMIT-1 study.
    Br J Dermatol 2016 Oct 6. Epub 2016 Oct 6.
    Cancer Research U.K. Clinical Trials Unit, School of Cancer Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K.
    Background: Topical imiquimod is sometimes used for lentigo maligna (LM) in situ melanoma instead of surgery, but frequency of cure is uncertain. Pathological complete regression (pCR) is a logical surrogate marker for cure after imiquimod, although residual LM and atypical melanocytic hyperplasia may not be reliably distinguished. A trial comparing imiquimod vs. Read More

    Downregulation of melanogenesis: drug discovery and therapeutic options.
    Drug Discov Today 2017 Feb 28;22(2):282-298. Epub 2016 Sep 28.
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 34134, South Korea.
    Melanin, primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a process called melanogenesis. However, the abnormal accumulation of melanin causes dermatological problems such as café-au-lait macules ephelides (freckles), solar lentigo (age spots) and melasma, as well as cancer and vitiligo. Hence the regulation of melanogenesis is very important for treating hyperpigmentary disorders. Read More

    In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs Surgeons.
    Dermatol Clin 2016 Oct;34(4):497-504
    Melanoma Unit, Dermatology Department, Hospital Clinic and Institut d'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain.
    Confocal microscopy is a modern imaging device that has been extensively applied in skin oncology. More specifically, for tumor margin assessment, it has been used in two modalities: reflectance mode (in vivo on skin patient) and fluorescence mode (on freshly excised specimen). Although in vivo reflectance confocal microscopy is an add-on tool for lentigo maligna mapping, fluorescence confocal microscopy is far superior for basal cell carcinoma and squamous cell carcinoma margin assessment in the Mohs setting. Read More

    Lentigo Maligna, Macules of the Face, and Lesions on Sun-Damaged Skin: Confocal Makes the Difference.
    Dermatol Clin 2016 Oct;34(4):421-429
    Dermatology, Sydney Melanoma Diagnostic Centre (SMDC), Royal Prince Alfred Hospital, Melanoma Institute Australia, Central Clinical School, Sydney University, Missenden Road, Camperdown, New South Wales 2050, Australia. Electronic address:
    Distinguishing lentigo maligna (LM) and lentigo maligna melanoma (LMM) from background pigmented non-melanoma lesions is challenging. The field of solar damage can obscure clinical assessment, and diagnostic ambiguities are created due to the overlap of the clinical features of LM with other benign lesions. Moreover, margin assessment on histology is limited by the resemblance between melanocytic hyperplasia of actinically damaged skin and scattered atypical melanocytes of LM/LMM. Read More

    Melanomas.
    Dermatol Clin 2016 Oct;34(4):411-419
    Dermatology Unit, UniMore, via del Pozzo, 71, Modena 41121, Italy.
    Melanomas are a wide range of tumors that differ in their epidemiology, morphology, genetic profile, and biological behavior. They can be grouped as superficial spreading melanoma, lentigo maligna, and nodular melanoma. Reflectance confocal microscopy is useful for the evaluation of skin lesions that are dermoscopically doubtful by increasing diagnostic accuracy and specificity. Read More

    Cutaneous Melanoma in Asians.
    Chonnam Med J 2016 Sep 23;52(3):185-93. Epub 2016 Sep 23.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Read More

    Associations between childhood height and morphologically different variants of melanoma in adulthood.
    Eur J Cancer 2016 Nov 16;67:99-105. Epub 2016 Sep 16.
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:
    Aim Of The Study: Melanoma subtypes have different aetiological characteristics. Child height is positively associated with adult melanoma; however, a clarification of associations with specific melanoma variants is necessary for an improved understanding of risk factors underlying the histologic entities. This study investigated associations between childhood height and future development of cutaneous melanoma variants. Read More

    Phototherapy in cosmetic dermatology.
    Clin Dermatol 2016 Sep-Oct;34(5):623-7. Epub 2016 May 20.
    Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago, IL. Electronic address:
    Light therapy has been incorporated into the art of healing and cosmesis for thousands of years and currently has found utility in many areas of medicine. Various modalities of cosmetic phototherapy are detailed, as well as the indications and mechanism of action for each modality. These modalities can be used to treat many common cosmetic conditions, including acne vulgaris, solar lentigo, and melasma. Read More

    Molecular and histological characterization of age spots.
    Exp Dermatol 2017 Mar 9;26(3):242-248. Epub 2017 Feb 9.
    R&D Front End Innovation, Beiersdorf AG, Hamburg, Germany.
    Age spots, also called solar lentigines and lentigo senilis, are light brown to black pigmented lesions of various sizes that typically develop in chronically sun-exposed skin. It is well known that age spots are strongly related to chronic sun exposure and are associated with photodamage and an increased risk for skin cancer; however, the mechanisms underlying their development remain poorly understood. We used immunohistochemical analysis and microarray analysis to investigate the processes involved in their formation, focusing on specific markers associated with the functions and proliferation of melanocytes and keratinocytes. Read More

    Segmental neurofibromatosis and cancer: report of triple malignancy in a woman with mosaic Neurofibromatosis 1 and review of neoplasms in segmental neurofibromatosis.
    Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.
    Department of Dermatology, University of California San Diego, San Diego, California.
    BackgroundSegmental neurofibromatosis, referred to as mosaic neurofibromatosis 1, patients present with neurofibromas or café au lait macules or both in a unilateral segment of the body.PurposeA woman with segmental neurofibromatosis and triple cancer (renal cell carcinoma, mixed thyroid carcinoma, and lentigo maligna) is described and cancers observed in patients with segmental neurofibromatosis are reviewed.MethodsPubMed was used to search the following terms, separately and in combination: cancer, malignancy, mosaic, neoplasm, neurofibroma, neurofibromatosis, segment, segmental, tumor. Read More

    Reflectance Confocal Microscopy in Lentigo Maligna.
    Actas Dermosifiliogr 2016 Dec 7;107(10):830-835. Epub 2016 Sep 7.
    Hospital Universitario Fundación de Alcorcón, Madrid, España.
    Lentigo maligna is the most common type of facial melanoma. Diagnosis is complicated, however, as it shares clinical and dermoscopic characteristics with other cutaneous lesions of the face. Reflectance confocal microscopy is an imaging technique that permits the visualization of characteristic features of lentigo maligna. Read More

    Survival and Surgical Outcomes for Pediatric Head and Neck Melanoma.
    JAMA Otolaryngol Head Neck Surg 2017 Jan;143(1):34-40
    Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle.
    Importance: Melanoma in children is rare, accounting for approximately 2% of all pediatric malignant neoplasms. However, for the past 30 years, the incidence of melanoma in those younger than 20 years has been increasing. Location of the primary tumor has been shown to be an important prognostic factor, with melanomas of the scalp and neck conferring a worse prognosis than those originating at other sites. Read More

    Histopathological diagnosis of acral lentiginous melanoma in early stages.
    Ann Diagn Pathol 2017 Feb 20;26:64-69. Epub 2016 Aug 20.
    Department of Pathology, Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Kaiser Permanente, Los Angeles, CA 90027-5969.
    Acral lentiginous melanoma is a rare variant of melanoma that is associated with a relatively low survival rate. The latter is partly due to the advanced stage in which the tumor is usually diagnosed. The diagnostic delay is mainly due to difficulties in identifying the very early histopathological signs of acral melanoma. Read More

    Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross-sectional study.
    J Eur Acad Dermatol Venereol 2017 Feb 5;31(2):355-360. Epub 2016 Sep 5.
    Department of Dermatology, Peking University People's Hospital, Beijing, China.
    Background: Skin ageing especially senile lentigo directly affects self-esteem. For decades, senile lentigo has been associated with chronic exposure to solar radiation. However, a study conducted recently in Caucasian subjects suggested that exposure to air pollution was significantly correlated with extrinsic skin ageing, in particular senile lentigines. Read More

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