31,342 results match your criteria Leishmaniasis

Visceral leishmaniasis: an unusual cause of isolated lymphadenopathy.

BMJ Case Rep 2022 06 22;15(6). Epub 2022 Jun 22.

Hematology, Cochin Hospital, APHP, Paris, France

View Article and Full-Text PDF

Probing O-substituted Nifuroxazide analogues against Leishmania: Synthesis, in vitro efficacy, and hit/lead identification.

Eur J Pharm Sci 2022 Jun 19:106242. Epub 2022 Jun 19.

Drug Discovery, Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address:

Leishmaniasis is a neglected tropical disease affecting millions of people worldwide, with 650 000 to 1.1 million new infections reported annually by the World Health Organization. Current antileishmanial treatments are unsatisfactory due to the development of parasitic resistance and the toxicity associated with the drugs used, and this highlights the need for the development of new antileishmanial drugs. Read More

View Article and Full-Text PDF

Effects of Structurally Different HDAC Inhibitors against , , and .

ACS Infect Dis 2022 Jun 22. Epub 2022 Jun 22.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

Neglected tropical diseases (NTDs), including trypanosomiasis, leishmaniasis, and schistosomiasis, result in a significant burden in terms of morbidity and mortality worldwide every year. Current antiparasitic drugs suffer from several limitations such as toxicity, no efficacy toward all of the forms of the parasites' life cycle, and/or induction of resistance. Histone-modifying enzymes play a crucial role in parasite growth and survival; thus, the use of epigenetic drugs has been suggested as a strategy for the treatment of NTDs. Read More

View Article and Full-Text PDF

Validation of a mixture of rK26 and rK39 antigens from Iranian strain of Leishmania infantum to detect anti-Leishmania antibodies in human and reservoir hosts.

Sci Rep 2022 Jun 21;12(1):10426. Epub 2022 Jun 21.

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mediterranean type of visceral leishmaniasis (VL) is a zoonotic parasitic infection. Some provinces of Iran are endemic for VL while other parts are considered as sporadic areas. This study aimed to assess a combination of recombinant K26 and rK39 antigens as well as crude antigen (CA), derived from an Iranian strain of L. Read More

View Article and Full-Text PDF

Cutaneous leishmaniasis in travellers and migrants: a 10-year case series in a Canadian reference centre for tropical diseases.

CMAJ Open 2022 Apr-Jun;10(2):E546-E553. Epub 2022 Jun 21.

Department of Medicine (Lemieux), Division of Dermatology, Centre Hospitalier de l'Université de Montréal; Department of Medicine (Lagacé, Billick), Division of Dermatology, McGill University Health Centre; J.D. MacLean Centre for Tropical Diseases at McGill University (Billick, Ndao, Yansouni, Semret, Libman, Barkati); National Reference Centre for Parasitology (Ndao), Research Institute of the McGill University Health Centre; Department of Medicine (Yansouni, Semret, Libman, Barkati), Division of Infectious Diseases, McGill University Health Centre, Montréal, Que.

Background: Cutaneous leishmaniasis is increasingly encountered in returned travellers and migrants to nonendemic countries. We sought to describe the clinical characteristics and treatment outcomes of cases of cutaneous leishmaniasis diagnosed at our reference centre over a 10-year period.

Methods: This case series included all laboratory-confirmed cases of cutaneous leishmaniasis in travellers and migrants for whom complete clinical data were available, diagnosed between January 2008 and October 2018 at the J. Read More

View Article and Full-Text PDF

Treatment outcome of imported cutaneous leishmaniasis among travellers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centres 2013 to 2019.

Int J Infect Dis 2022 Jun 18. Epub 2022 Jun 18.

Division of Dermatology and Venerology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travellers and migrants in Europe.

Methods: A retrospective study of parasitological confirmed CL cases caused by L. Read More

View Article and Full-Text PDF

First report of imported canine visceral leishmaniasis cases in Panama, Central America: Public health implications.

Vet Parasitol Reg Stud Reports 2022 Jul 3;32:100745. Epub 2022 Jun 3.

Departamento de Investigación en Parasitología, Instituto Conmemorativo Gorgas de Estudios de la Salud (ICGES), Ave. Justo Arosemena, Calidonia, 0816-02593, Ciudad de Panamá, Panama; Departamento de Microbiología Humana, Facultad de Medicina, Universidad de Panamá, Ave. Octavio Méndez Pereira, Ciudad de Panamá, Panama. Electronic address:

According to the last leishmaniasis report from the Pan American Health Organization (2021) so far Panama is considered free of visceral leishmaniasis (VL). Although the presence of potential vectors and reservoirs involved in the VL transmission cycle have been described in some rural regions of the country, no cases have been reported in humans and domestic or wild animals. Dogs play an important role in the urban transmission of VL; therefore, it is important to detect possible cases of canine visceral leishmaniasis (CVL) in the country. Read More

View Article and Full-Text PDF

Vector-borne pathogens in dogs from areas where leishmaniosis is endemic.

Vet Parasitol Reg Stud Reports 2022 Jul 9;32:100746. Epub 2022 Jun 9.

Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.

Many vector-borne pathogens (VBPs), including Ehrlichia canis and Dirofilaria immitis, may infect simultaneously dogs in areas where Leishmania infantum is endemic, especially in the tropics, where highly abundant arthropod vectors thrive. The aim of this study was to compare the frequency of simultaneous VBPs infection in Leishmania-positive and Leishmania-negative dogs. Animals enrolled in this study were divided in two groups (G1 and G2), G1 being comprised of L. Read More

View Article and Full-Text PDF

Bats as hosts of Leishmania (Leishmania) infantum in Minas Gerais, an endemic area for visceral leishmaniasis.

Vet Parasitol Reg Stud Reports 2022 Jul 18;32:100740. Epub 2022 May 18.

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Bats are parasitized by a wide spectrum of ecto and endoparasites, but their role as a reservoir for some zoonoses is not fully understood. The objective of this work was to evaluate the presence of Leishmania DNA in the blood of bats from 30 municipalities in the state of Minas Gerais, Brazil. We analyzed samples of 120 bats, covering 29 species. Read More

View Article and Full-Text PDF

Distribution and epidemiological features of cutaneous leishmaniasis in Asir province, Saudi Arabia, from 2011 to 2020.

Yasser Alraey

J Infect Public Health 2022 Jun 11;15(7):757-765. Epub 2022 Jun 11.

Department of Clinical Laboratory Sciences, Central Research Laboratory, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. Electronic address:

Background: Cutaneous leishmaniasis (CL) places a major burden on the health authorities in Saudi Arabia. Information about the geographical reach and seasonality of CL in Asir province remains limited. Therefore, this study aimed to investigate the epidemiological features of CL in southwest Saudi Arabia. Read More

View Article and Full-Text PDF

Time Series Transcriptomic Analysis by RNA Sequencing Reveals a Key Role of PI3K in Sepsis-Induced Myocardial Injury in Mice.

Front Physiol 2022 1;13:903164. Epub 2022 Jun 1.

Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China.

Septic cardiomyopathy is the main complication and cause of death of severe sepsis with limited therapeutic strategy. However, the molecular mechanism of sepsis-induced cardiac injury remains unclear. The present study was designed to investigate differentially expressed genes (DEGs) involved in the pathogenesis of septic cardiomyopathy induced by cecal ligation and puncture (CLP) in mice. Read More

View Article and Full-Text PDF

Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis.

R Soc Open Sci 2022 Jun 15;9(6):220058. Epub 2022 Jun 15.

Biomaterials, Drug Delivery and Nanotechnology Unit, Center for Biomedical and Biomaterials Research, University of Mauritius, Réduit 80837, Mauritius.

Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Read More

View Article and Full-Text PDF

Homology Modeling, Design of Ligands, and Molecular Docking Identify Potential Inhibitors of 24-Sterol Methyltransferase.

Front Cell Infect Microbiol 2022 2;12:859981. Epub 2022 Jun 2.

Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Accra, Ghana.

The therapeutic challenges pertaining to leishmaniasis due to reported chemoresistance and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory molecules. 24-sterol methyltransferase (SMT) is vital for the synthesis of ergosterols, the main constituents of cellular membranes. So far, mammals have not been shown to possess SMT or ergosterols, making the pathway a prime candidate for drug discovery. Read More

View Article and Full-Text PDF

A Network Pharmacology Approach for Uncovering the Mechanism of 'Kouchuangling' in Radiation-induced Oral Mucositis Treatment.

Comb Chem High Throughput Screen 2022 Jun 17. Epub 2022 Jun 17.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Background: Radiation-induced oral mucositis (RIOM) is an intractable inflammatory disease whose pathogenesis needs to be clarified. "Kouchuangling" (KCL), a traditional Chinese medicine formula, is composed of Lonicerae Japonicae Flos, Radix Paeoniae Rubra, and Radix Sanguisorbae. Although all of them are Chinese folk medicines which have long been utilized for ameliorating inflammation, the mechanism of KCL to RIOM remains unclear. Read More

View Article and Full-Text PDF

Pamidronate, a promising repositioning drug to treat leishmaniasis, displays antileishmanial and immunomodulatory potential.

Int Immunopharmacol 2022 Jun 15;110:108952. Epub 2022 Jun 15.

Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum (L. infantum). Currently, there are no vaccines and/or prophylactic therapies against VL, and the recentpharmacological approaches come from the drug repositioning strategy. Read More

View Article and Full-Text PDF

Livestock infected with Leishmania spp. in southern Iran.

Parasit Vectors 2022 Jun 17;15(1):215. Epub 2022 Jun 17.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Query ID="Q1" Text="Graphical abstract: As per journal requirements, graphical abstract is necessary. Kindly check and provide the same."The magnitude of the health problems caused by leishmaniasis has been a major driving factor behind the development and implementation of leishmaniasis control programs by the national authorities in Iran, with a priority for health and environmental management. Read More

View Article and Full-Text PDF

Comparison of serum cytokine levels in symptomatic and asymptomatic HIV-Leishmania coinfected individuals from a Brazilian visceral leishmaniasis endemic area.

PLoS Negl Trop Dis 2022 Jun 17;16(6):e0010542. Epub 2022 Jun 17.

Department of Parasitology, Aggeu Magalhães Institute-Oswaldo Cruz Foundation (Fiocruz), Recife, Pernambuco, Brazil.

Background: Visceral leishmaniasis (VL) remains an important infectious disease worldwide. VL-HIV coinfected individuals can present with atypical clinical forms of VL and have a high risk of VL relapse. Some cytokines have been described as potential markers to diagnose active VL and to predict the severity of the cases. Read More

View Article and Full-Text PDF

The role of ATP-binding cassette transporter genes expression in treatment failure cutaneous leishmaniasis.

AMB Express 2022 Jun 16;12(1):78. Epub 2022 Jun 16.

Research Center for Food Hygiene and Safety, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Leishmaniasis is one of the common diseases transmitted by sand flies in tropical and subtropical regions of the world. Currently, antimonial derivatives are the first line of treatment. Some of the members of the ATP-binding cassette (ABC) family of Leishmania are shown to be associated with no response to treatment. Read More

View Article and Full-Text PDF

Therapeutic effects of Lucilia sericata larval excretion/secretion products on Leishmania major under in vitro and in vivo conditions.

Parasit Vectors 2022 Jun 16;15(1):212. Epub 2022 Jun 16.

Department of Parasitology and Medical Entomology, Faculty of Medical Sciences, Tarbiat Modares University, Jalal AleAhmad Highway, Nasr, P.O. Box 14115-111, Tehran, Islamic Republic of Iran.

Background: Leishmaniasis is a neglected infectious disease caused by protozoa of the genus Leishmania. The disease generally manifests as characteristic skin lesions which require lengthy treatment with antimonial drugs that are often associated with adverse side effects. Therefore, a number of studies have focused on natural compounds as promising drugs for its treatment. Read More

View Article and Full-Text PDF

Molecular detection of Leishmania infantum in rats and sand flies in the urban sewers of Barcelona, Spain.

Parasit Vectors 2022 Jun 16;15(1):211. Epub 2022 Jun 16.

Parasite and Health Research Group, Department of Pharmacy, Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, 46100, Burjassot, Valencia, Spain.

Background: Classically, dogs have been considered to be the only reservoir of leishmaniasis in urban areas. However, in a previous study, we found a 33.3% prevalence of Leishmania infantum in the spleens of Norway rats (Rattus norvegicus) sampled in the underground sewer system of the city of Barcelona (Spain). Read More

View Article and Full-Text PDF

A structural vaccinology approach for in silico designing of a potential self-assembled nanovaccine against Leishmania infantum.

Exp Parasitol 2022 Jun 14;239:108295. Epub 2022 Jun 14.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Visceral leishmaniasis (VL) remains a major public health problem across 98 countries. To date, VL has no effective drug. Vaccines, as the most successful breakthroughs in medicine, can promise an effective strategy to fight various diseases. Read More

View Article and Full-Text PDF

How to get away with murder: The multiple strategies employed by pathogenic protozoa to avoid complement killing.

Mol Immunol 2022 Jun 13;149:27-38. Epub 2022 Jun 13.

Departamento de Parasitologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Parasitic protozoa are eukaryotic unicellular organisms that depend on a variety of living organisms and can develop intra- and extracellularly inside their hosts. In humans, these parasites cause diseases with a significant impact on public health, such as malaria, toxoplasmosis, Chagas disease, leishmaniasis and amebiasis. The ability of a parasite in establishing a successful infection depends on a series of intricate evolutionarily selected adaptations, which include the development of molecular and cellular strategies to evade the host immune system effector mechanisms. Read More

View Article and Full-Text PDF

The optimization of PpSP15 purification from salivary glands in Iranian wild (Diptera: Psychodidae).

J Vector Borne Dis 2022 Jan-Mar;59(1):63-69

Molecular Systematics Laboratory, Parasitology Department, Pasteur Institute of Iran, Tehran, Iran.

Background & Objectives: Sand fly saliva contains proteins that modulate the host immune system and it plays an important role in both blood feeding and the outcome of Leishmania infections. The profile of the salivary proteins was examined and analyzed from an endemic focus of zoonotic cutaneous leishmaniasis by wild P. papatasi to find local and suitable antigens as potential proteins for developing Leishmania vaccine alongside the development of a new extraction technique. Read More

View Article and Full-Text PDF

Evaluation of the inhibitory potential of Valproic acid against histone deacetylase of and computational studies of Valproic acid derivatives.

J Biomol Struct Dyn 2022 Jun 15:1-18. Epub 2022 Jun 15.

Computational Biology & Biotechnology Laboratory, Department of Botany, Soban Singh Jeena University, Almora, Uttarakhand, India.

Valproic acid (VA) is a proven inhibitor of human histone deacetylases (HDACs). The homogenous HDAC has been associated with all major human parasitic pathogens and hence, it has been considered an attractive drug target for anti-leishmanial therapy. To assist in drug design endeavors for HDACs, an in- study has been presented to investigate the VA inhibition on HDAC (HDAC). Read More

View Article and Full-Text PDF

Leishmania braziliensis causing human disease in Northeast Brazil presents loci with genotypes in long-term equilibrium.

PLoS Negl Trop Dis 2022 Jun 15;16(6):e0010390. Epub 2022 Jun 15.

Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia (UFBA), Salvador, Brazil.

Background: Leishmaniases are neglected tropical diseases that inflict great burden to poor areas of the globe. Intense research has aimed to identify parasite genetic signatures predictive of infection outcomes. Consistency of diagnostic tools based on these markers would greatly benefit from accurate understanding of Leishmania spp. Read More

View Article and Full-Text PDF

The scientific publication of the Memórias do Instituto Oswaldo Cruz (1909-2020): a history of contribution to the biomedical sciences.

Mem Inst Oswaldo Cruz 2022 13;117:e210376. Epub 2022 Jun 13.

Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular, Rio de Janeiro, RJ, Brasil.

Background: The Memórias do Instituto Oswaldo Cruz (MIOC) is one of the first scientific journals created in Brazil and currently one of the most important biomedical journals in South America. Knowledge of the main themes disseminated over time and its main contributors can contribute towards a better understanding of its trajectory and future.

Objectives: Map the journal's scientific publication between 1909 and 2020. Read More

View Article and Full-Text PDF

Analysis of Pharmacological Activities and Mechanisms of Essential Oil in Leaves of C. grandis 'Tomentosa' by GC-MS/MS and Network Pharmacology.

Comb Chem High Throughput Screen 2022 Jun 10. Epub 2022 Jun 10.

School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.

Background: Citrus grandis 'Tomentosa', as the fruit epicarp of C. grandis 'Tomentosa' or C. grandis (L. Read More

View Article and Full-Text PDF

Leishmania exposure in dogs from two endemic countries from New and Old Worlds (Brazil and Portugal): evaluation of three serological tests using Bayesian Latent Class Models.

Parasit Vectors 2022 Jun 13;15(1):202. Epub 2022 Jun 13.

Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Lisbon, Portugal.

Background: Zoonotic leishmaniosis caused by Leishmania infantum is endemic in several countries of the Mediterranean Basin, Latin America, and Asia. Dogs are the main hosts and reservoirs of human infection. Thus, from a One Health perspective, early diagnosis of Leishmania infection in dogs is essential to control the dissemination of the parasite among other dogs and to humans. Read More

View Article and Full-Text PDF

Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches.

BMC Complement Med Ther 2022 Jun 13;22(1):156. Epub 2022 Jun 13.

Centro de Investigaciones y Transferencia Villa María (CIT VM), Instituto Académico Pedagógico de Ciencias Humanas, Universidad Nacional de Villa María, Arturo Jauretche 1555, X5900 Villa María, Córdoba, Argentina.

Introduction: Despite the number of deaths and the significant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side effects and high toxicity for the patient. Therefore, there is an urgent need for safe, low-cost, and effective treatments. Natural products are an important source of bioactive compounds and there is current interest in finding natural bioactive molecules that can be used for treating these parasitic diseases. Read More

View Article and Full-Text PDF

Ascaridole exerts the leishmanicidal activity by inhibiting parasite glycolysis.

Phytomedicine 2022 Aug 3;103:154221. Epub 2022 Jun 3.

Department of Pharmacology, Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata, WB 700 020, India. Electronic address:

Background: The global burden of leishmaniasis is exacerbated by the limited repertoire of drugs, resulting in an urgent need to develop new therapeutic alternatives. Endoperoxides like ascaridole have emerged as promising anti-parasitic candidates, and its effectiveness was established in an animal model of cutaneous leishmaniasis (CL). However, its impact on Leishmania donovani parasites, causative of visceral leishmaniasis (VL) remains to be established. Read More

View Article and Full-Text PDF