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    A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to themetabolome caused by miltefosine.
    Antimicrob Agents Chemother 2018 Feb 20. Epub 2018 Feb 20.
    Centre for Metabolomics and Bioanalysis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain
    With the World Health Organization reporting over 30,000 deaths and 200-400,000 new cases annually, visceralsis is a serious disease affecting some of the world's poorest people. As drug resistance continues to rise, there is a huge unmet need to improve treatment. Miltefosine remains one of the main treatments forsis, yet its mode of action (MoA) is still unknown. Read More

    Human visceral leishmaniasis: factors associated with deaths in Belo Horizonte, Minas Gerais state, Brazil from 2006 to 2013.
    Epidemiol Infect 2018 Feb 21:1-6. Epub 2018 Feb 21.
    Department of Veterinary Medicine,Federal University of Lavras,Lavras, Minas Gerais,Brazil.
    The aim of this study was to evaluate the distribution of cases and the social determinants associated with death from human visceral leishmaniasis (HVL) and VL-HIV co-infection in Belo Horizonte, Minas Gerais state, Brazil, between 2006 and 2013. Descriptive statistics and analysis of associations were performed using chi-square of the raised variables, such as sex, age, skin colour and schooling of cases of HVL. During the study period, there were 866 cases of HVL with 111 deaths in Belo Horizonte. Read More

    [Current and future ecological niche of Leishmaniasis (Kinetoplastida: Trypanosomatidae) in the Neotropical region].
    Rev Biol Trop 2016 Sep;64(3):1237-45
    The leishmaniasis is a complex disease system, caused by the protozoan parasite Leishmania and transmitted to humans by the vector Lutzomyia spp. Since it is listed as a neglected disease according to the World Health Organization, the aim of this study was to determine the current and future niche of cutaneous and visceral leishmaniasis in the Neotropical region. We built the ecological niche model (ENM) of cutaneous (N= 2 910 occurrences) and visceral (N= 851 occurrences) leishmaniasis using MaxEnt algorithm. Read More

    Development of (6R)-2-nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (DNDI-8219): a new lead for visceral leishmaniasis.
    J Med Chem 2018 Feb 20. Epub 2018 Feb 20.
    Discovery of the potent antileishmanial effects of antitubercular 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles and 7-substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines stimulated the examination of further scaffolds (e.g., 2-nitro-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]oxazepines) but the results for these seemed less attractive. Read More

    Leishmaniasis in northern Cyprus: Human cases and their association with risk factors.
    J Vector Borne Dis 2017 Oct-Dec;54(4):358-365
    Faculty of Medicine, Department of Medical Microbiology and Clinical Microbiology, Near East University, Nicosia, Northern Cyprus; Faculty of Medicine, Department of Medical Microbiology, Hitit University, Corum, Turkey.
    Background & Objectives: Cyprus is located in the eastern part of the Mediterranean Region where leishmaniasis is endemic. The primary objective of this study was to investigate human visceral leishmaniasis (VL) in the northern region of Cyprus where presence of canine leishmaniasis (CanL) and sandflies has been documented in earlier studies. The secondary objective was to assess the association of leishmaniasis with demographic and epidemiological variables. Read More

    High seroprevalence and peripheral spatial distribution of visceral leishmaniasis among domestic dogs in an emerging urban focus in Central Brazil: a cross-sectional study.
    Pathog Glob Health 2018 Feb 20:1-8. Epub 2018 Feb 20.
    b School of Medicine , Post-Graduation Program in Health Sciences, Federal University of Mato Grosso , Cuiabá , Brazil.
    The Brazilian municipality of Rondonópolis is an emerging urban focus of intense transmission of visceral leishmaniasis (VL), where few investigations have addressed canine reservoirs. This study assessed the seroprevalence and spatial distribution of canine visceral leishmaniasis (CVL) in the urban area of Rondonópolis. A CVL serosurvey was conducted between October 2016 and February 2017 using an immunochromatographic rapid test and enzyme-linked immunosorbent assay. Read More

    Decanethiol functionalized silver nanoparticles are new powerful leishmanicidals in vitro.
    World J Microbiol Biotechnol 2018 Feb 19;34(3):38. Epub 2018 Feb 19.
    Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Av. Patricio Trueba de Regil s/n, Col. Lindavista, C.P. 24090, San Francisco de Campeche, Camp, Mexico.
    We evaluated, for the first time, the leishmanicidal potential of decanethiol functionalized silver nanoparticles (AgNps-SCH) on promastigotes and amastigotes of different strains and species of Leishmania: L. mexicana and L. major isolated from different patients suffering from localized cutaneous leishmaniasis (CL) and L. Read More

    Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of, but Not for Spontaneous Cure of Subcutaneous Primary or SecondaryInfection.
    Front Immunol 2018 5;9:79. Epub 2018 Feb 5.
    Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
    We previously showed that in mice infected withtype I interferons (IFNs) initiate the innate immune response to the parasite at day 1 and 2 of infection. Here, we investigated which type I IFN subtypes are expressed during the first 8 weeks ofinfection and whether type I IFNs are essential for a protective immune response and clinical cure of the disease. In self-healing C57BL/6 mice infected with a high dose of, IFN-α4, IFN-α5, IFN-α11, IFN-α13, and IFN-β mRNA were most prominently regulated during the course of infection. Read More

    Phlebotomine sand flies (Diptera: Psychodidae) in the Greek Aegean Islands: ecological approaches.
    Parasit Vectors 2018 Feb 20;11(1):97. Epub 2018 Feb 20.
    Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, School of Medicine, University of Crete, Vassilika Vouton, GR-71003, Heraklion, Greece.
    Background: Blood-sucking phlebotomine sand flies are the vectors of the protozoan parasites Leishmania spp. Different Phlebotomus species transmit different Leishmania species causing leishmaniases which are neglected diseases emerging/reemerging in new regions. Thirteen sand fly species, ten belonging to the medically important genus Phlebotomus and three belonging to Sergentomyia are known in Greece. Read More

    CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses.
    BMC Bioinformatics 2018 Feb 20;19(1):56. Epub 2018 Feb 20.
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
    Background: The analysis of modular gene co-expression networks is a well-established method commonly used for discovering the systems-level functionality of genes. In addition, these studies provide a basis for the discovery of clinically relevant molecular pathways underlying different diseases and conditions.

    Results: In this paper, we present a fast and easy-to-use Bioconductor package named CEMiTool that unifies the discovery and the analysis of co-expression modules. Read More

    Ground ultra low volume (ULV) space spray applications for the control of wild sand fly populations (Psychodidae: Phlebotominae) in Europe.
    Acta Trop 2018 Feb 16. Epub 2018 Feb 16.
    European Biological Control Laboratory, USDA-ARS, Tsimiski 43, 54623, Thessaloniki, Greece.
    The Phlebotomus sand flies are considered an important vector of both canine and human leishmaniasis. Current measures for sand fly control include mostly indoor interventions, such as residual spraying of dwellings (IRS) to target endophilic sand fly species with very limited number of vector control tools for outdoor interventions against exophilic sand flies. In this study we investigated the efficacy of ground ultra low volume (ULV) space spray applications of a deltamethrin based product against field populations of P. Read More

    Identification of wild-caught phlebotomine sand flies from Crete and Cyprus using DNA barcoding.
    Parasit Vectors 2018 Feb 17;11(1):94. Epub 2018 Feb 17.
    Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, School of Medicine, University of Crete, Vassilika Vouton, P.O. Box 2208, GR-71003, Heraklion, Greece.
    Background: Phlebotomine sand flies (Diptera: Psychodidae) are vectors of Leishmania spp., protozoan parasites responsible for a group of neglected diseases called leishmaniases. Two sand fly genera, Phlebotomus and Sergentomyia, contain species that are present in the Mediterranean islands of Crete and Cyprus where the visceral (VL), cutaneous (CL) and canine (CanLei) leishmaniases are a public health concern. Read More

    Comments on "A Mathematical Study to Control Visceral Leishmaniasis: An Application to South Sudan".
    Bull Math Biol 2018 Feb 16. Epub 2018 Feb 16.
    School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA.
    Deterministic (ordinary differential equation) models for the transmission dynamics of vector-borne diseases that incorporate disease-induced death in the host(s) population(s) are generally known to exhibit the phenomenon of backward bifurcation (where a stable disease-free equilibrium of the model coexists with a stable endemic equilibrium when the associated reproduction number of the model is less than unity). Further, it is well known that, in these models, the phenomenon of backward bifurcation does not occur when the disease-induced death rate is negligible (e.g. Read More

    Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole.
    Acta Trop 2018 Feb 13. Epub 2018 Feb 13.
    Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Arthur de Sá s/n, Cidade Universitária, CEP 50740-520, Recife, PE, Brazil. Electronic address:
    Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market for treating the disease. Read More

    Recent progress in drug targets and inhibitors towards combating leishmaniasis.
    Acta Trop 2018 Feb 13;181:95-104. Epub 2018 Feb 13.
    Department of Molecular Biology/Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007, India.
    Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the genus Leishmania. The disease has more than one clinical forms and the visceral form is considered fatal. With the lack of potential vaccine, chemotherapy is the major treatment source considered for the control of the disease in the infected people. Read More

    American tegumentary leishmaniasis: diagnostic and treatment challenges in a clinical case.
    Rev Inst Med Trop Sao Paulo 2018 15;60:e3. Epub 2018 Feb 15.
    Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
    This clinical case presents a patient with a raised and ulcerative lesion with erythematous edges in the mouth, on the lower lip that was unsuccessfully treated as herpes labialis. Clinical data and laboratory tests (Montenegro skin test, indirect immunofluorescence, direct parasite search and polymerase chain reaction) led to the diagnosis of American tegumentary leishmaniasis caused by Leishmania (Viannia) sp. Treatment with pentavalent antimonial (Glucantime®) for 120 days was not effective and administration of amphotericin B for 30 days resulted in wound healing. Read More

    First case report of atypical disseminated cutaneous leishmaniasis in an opium abuser in Iran.
    Rev Inst Med Trop Sao Paulo 2018 15;60:e5. Epub 2018 Feb 15.
    Razi Vaccine and Serum Research Institute, Mashhad, Iran.
    Leishmaniasis is a worldwide tropical infectious disease caused by different species of intracellular protozoa parasites of the genus Leishmania . Herein, we report a 78-year-old man with unusual diffuse cutaneous leishmaniasis (DCL) who had a history of opium abuse and chronic obstructive pulmonary disease (COPD). He had multiple papular, crusted and severely ulcerated lesions extended to his arm and chest. Read More

    Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama.
    Rev Inst Med Trop Sao Paulo 2018 15;60:e8. Epub 2018 Feb 15.
    Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama.
    Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V. Read More

    An outbreak of cutaneous leishmaniasis in Modena province (Northern Italy): report of 35 cases.
    Pathologica 2017 Dec;109(4):363-367
    Department of Microbiology and Virology Unit, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
    Canine Leishmaniasis is a disease endemic in many parts of Europe, carried by insects of phlebotomous species. Humans are occasional hosts of the parasites. Cases of human leishmaniasis have been registered in Italy, particularly in the southern and coastal regions. Read More

    Onychomycosis due to dermatophytes species in Iran: Prevalence rates, causative agents, predisposing factors and diagnosis based on microscopic morphometric findings.
    J Mycol Med 2018 Feb 12. Epub 2018 Feb 12.
    Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
    Objective: Onychomycosis (OM) or fungal nail infection is one of the most common fungal infections, which is increasingly prevalent. OM is caused by dermatophytes spp, yeasts and non-dermatophyte moulds (NDMs). The purpose of this study was to identify and determine the prevalence rates, predisposing factors and causative agents of OM using clinical symptoms and microscopic morphometric findings. Read More

    Comparing the therapeutic efficacy of different amphotericin B-carrying delivery systems against visceral leishmaniasis.
    Exp Parasitol 2018 Feb 13;186:24-35. Epub 2018 Feb 13.
    Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address:
    Amphotericin B (Amp) has been well-successfully used to treat against Leishmania infection, although high toxicity has been found in patients. In the present study, Amp was administered in Leishmania infantum-infected BALB/c mice by three distinct delivery systems aiming to compare their efficacy against challenge infection, as well as their side effects in a murine visceral leishmaniasis (VL) model. This product was administered in a Poloxamer P407 (PluronicF127)-based polymeric micelle system (Amp/M), in the Ambisomeformulation (Lip-Amp) or in a free format (free Amp). Read More

    Isolation of Crithidia spp. from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran.
    Trop Med Int Health 2018 Feb 15. Epub 2018 Feb 15.
    Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Objective: Leishmania major has been considered as the main etiological agent of cutaneous leishmaniasis in Iran. However, there are recent reports about existence of Crithidia spp in cutaneous lesions in southern Iran. Therefore, this study was designed to decipher some morphological, biological, and molecular aspects of this phenomenon. Read More

    Corrigendum to "Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study".
    Adv Med 2017 28;2017:7192180. Epub 2017 Dec 28.
    Dermatology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    [This corrects the article DOI: 10.1155/2016/5918393.]. Read More

    Distribution and Seasonal Activity of Phlebotominae Sand Flies in Yazd and Its Outskirts, Center of Iran.
    ScientificWorldJournal 2017 27;2017:1486845. Epub 2017 Dec 27.
    Yazd Health Center, Yazd, Iran.
    Background: Phlebotominae sand flies are the main vectors of leishmaniasis and some other diseases.

    Materials And Methods: Using sticky traps, sand flies were collected fortnightly from outdoors and indoors areas of selected sites.

    Results: A total of 2032 specimens (498 in the city and 1534 in the outskirts of Yazd) belonging to 11 species were collected. Read More

    Evaluation of the Elecsys® Chagas Assay for the Detection ofSpecific Antibodies in a Multicenter Study in Europe and Latin America.
    J Clin Microbiol 2018 Feb 14. Epub 2018 Feb 14.
    National Reference Centre for Tropical Infectious Agents, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany .
    Serology is the preferred method to confirm Chagas disease diagnosis and to screen blood donors. A battery of assays is often required due to the limited accuracy of single assays. The Elecsys® Chagas assay is a newly developed, double-antigen sandwich assay for use on the Elecsys® and cobas® e immunoassay analyzers, intended to identify individuals infected withfor diagnosis and screening. Read More

    Health economic evaluation of moist wound care in chronic cutaneous leishmaniasis ulcers in Afghanistan.
    Infect Dis Poverty 2018 Feb 14;7(1):12. Epub 2018 Feb 14.
    Institute of Public Health, University Hospital Heidelberg, Heidelberg, Germany.
    Background: The present health economic evaluation in Afghanistan aims to support public health decision makers and health care managers to allocate resources efficiently to appropriate treatments for cutaneous leishmaniasis (CL) elicited by Leishmania tropica or Leishmania major.

    Methods: A decision tree was used to analyse the cost and the effectiveness of two wound care regimens versus intra-lesional antimony in CL patients in Afghanistan. Costs were collected from a societal perspective. Read More

    In vitro antileishmanial and cytotoxicity activities of essential oils from Haplophyllum tuberculatum A. Juss leaves, stems and aerial parts.
    BMC Complement Altern Med 2018 Feb 14;18(1):60. Epub 2018 Feb 14.
    Pharmacognosy Research Group (GNOS), Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL), B1.72.03 Av. E. Mounier 72, B-1200, Bruxelles, Belgium.
    Background: Plants used for traditional medicine produce diverse and complex secondary metabolites exhibiting various medicinal properties. The medicinal plant Haplophyllum tuberculatum is used by native people against malaria and parasitic infections.

    Methods: In this study and in order to contribute for the search of new natural drugs for leishmaniasis, the essential oils of H. Read More

    Sensitive and less invasive confirmatory diagnosis of visceral leishmaniasis in Sudan using loop-mediated isothermal amplification (LAMP).
    PLoS Negl Trop Dis 2018 Feb 14;12(2):e0006264. Epub 2018 Feb 14.
    Foundation for Innovative New Diagnostics-FIND, Geneva, Switzerland.
    Background: Confirmatory diagnosis of visceral leishmaniasis (VL), as well as diagnosis of relapses and test of cure, usually requires examination by microscopy of samples collected by invasive means, such as splenic, bone marrow or lymph node aspirates. This causes discomfort to patients, with risks of bleeding and iatrogenic infections, and requires technical expertise. Molecular tests have great potential for diagnosis of VL using peripheral blood, but require well-equipped facilities and trained personnel. Read More

    Liposomal Elongation Factor-1α Triggers Effector CD4 and CD8 T Cells for Induction of Long-Lasting Protective Immunity against Visceral Leishmaniasis.
    Front Immunol 2018 30;9:18. Epub 2018 Jan 30.
    Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
    Despite advances, identification and formulation of safe and effective vaccine for long-lasting protection against leishmaniasis is still inadequate. In this study, we have identified a novel antigen, leishmanial elongation factor-1α (EF1-α), as an immunodominant component of solubilized leishmanial membrane antigens that reacts with visceral leishmaniasis (VL) sera and induces cellular proliferative and cytokine response in PBMCs of cured VL subjects. Leishmanial EF1-α is a 50 kDa antigen that plays a crucial role in pathogen survival by regulating oxidative burst in the host phagocytes. Read More

    Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis.
    Sci Rep 2018 Feb 13;8(1):2898. Epub 2018 Feb 13.
    Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
    The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. Read More

    CRISPR/Cas9 in Leishmania mexicana: A case study of LmxBTN1.
    PLoS One 2018 13;13(2):e0192723. Epub 2018 Feb 13.
    Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.
    Leishmania parasites cause human cutaneous, mucocutaneous and visceral leishmaniasis. Several studies proposed involvement of certain genes in infectivity of these parasites based on differential mRNA expression data. Due to unusual gene expression mechanism, functions of such genes must be further validated experimentally. Read More

    Some aspects of entomological determinants of Phlebotomus orientalis in highland and lowland visceral leishmaniasis foci in northwestern Ethiopia.
    PLoS One 2018 13;13(2):e0192844. Epub 2018 Feb 13.
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
    Visceral leishmaniasis (VL) is one of the major public health problems in northwest Ethiopia, mainly in Libo-Kemkem and Metema districts, where Phlebotomus orientalis is the most probable vector of the disease. The aim of this study was to determine the physiological age, host preference and vectorial potential of P. orientalis in the highland and lowland foci of the region. Read More

    Inhibitor of Serine Peptidases 2 Mediated Inhibition of Lectin Pathway and Upregulation of C5aR Signaling Promote Parasite Survival inside Host.
    Front Immunol 2018 29;9:63. Epub 2018 Jan 29.
    Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna, India.
    , the causative agent of Indian visceral leishmaniasis has to face several barriers of the immune system inside the mammalian host for its survival. The complement system is one of the first barriers and consists of a well-balanced network of proteases including S1A family serine proteases (SPs). Inhibitor of serine peptidases (ISPs) is considered as inhibitor of S1A family serine peptidases and is reported to be present in trypanosomes, including. Read More

    Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region.
    PLoS Negl Trop Dis 2018 Feb 12;12(2):e0006233. Epub 2018 Feb 12.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.
    Background: Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy leads to stigma towards people with the disease. This study aimed at exploring the knowledge, perceptions and attitudes regarding leprosy in rural Cameroon. Read More

    Sensitivity and specificity of an in-clinic point-of-care PCR test for the diagnosis of canine leishmaniasis.
    Vet J 2018 Feb 9;232:46-51. Epub 2017 Dec 9.
    Clinic of Small Animal Medicine, LMU Munich, Veterinaerstr. 13, 80539 Munich, Germany.
    Canine leishmaniasis is an important infectious disease worldwide. Although commonly used, antibody tests are often falsely negative, and in such cases direct detection of the pathogen, such as PCR, is necessary. However, PCR is only performed in specialized laboratories and not available in all localities. Read More

    Climate and environmental factors affecting the incidence of cutaneous leishmaniasis in Isfahan, Iran.
    Environ Sci Pollut Res Int 2018 Feb 9. Epub 2018 Feb 9.
    Communicable Diseases Management Center, Ministry of Health and Medical Education, Tehran, Iran.
    Cutaneous leishmaniasis (CL) is a vector-borne human disease caused by Leishmania, a parasite transmitted by sand flies. CL is endemic in the Isfahan Province, Iran. This study was designed to identify the climate and environmental factors associated with CL incidence in Isfahan Province. Read More

    Fabrication of 3-O-sn-Phosphatidyl-L-serine Anchored PLGA Nanoparticle Bearing Amphotericin B for Macrophage Targeting.
    Pharm Res 2018 Feb 9;35(3):60. Epub 2018 Feb 9.
    Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, UP, 226031, India.
    Purpose: To fabricate, characterize and evaluate 3-O-sn-Phosphatidyl-L-serine (PhoS) anchored PLGA nanoparticles for macrophage targeted therapeutic intervention of VL.

    Materials And Methods: PLGA-AmpB NPs were prepared by well-established nanoprecipitation method and decorated with Phos by thin film hydration method. Physico-chemical characterization of the formulation was done by Zetasizer nano ZS and atomic force microscopy. Read More

    In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series.
    Int J Parasitol Drugs Drug Resist 2018 Jan 31;8(1):81-86. Epub 2018 Jan 31.
    Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Belgium. Electronic address:
    Objectives: Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. Pharmacodynamics studies included both in vitro and in vivo efficacy, cross-resistance profiling against the current antileishmanial reference drugs and evaluation of their cidal activity potential.

    Methods: Efficacy against the reference laboratory strains of Leishmania infantum (MHOM/MA(BE)/67/ITMAP263) and L. Read More

    [When to ask for a skin biopsy in a patient with leg ulcer? Retrospective study of 143 consecutive biopsies].
    J Med Vasc 2018 Feb 21;43(1):4-9. Epub 2017 Nov 21.
    Service de médecine vasculaire, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.
    Objective: A vascular cause is found in around 85% of leg ulcer patients, but non-vascular causes are also observed. Their diagnosis is based on a set of clinical arguments and skin biopsy with histological analysis. The aim of this study was to analyze the results of these biopsies and to find common criteria for ulcers whose skin biopsies had led to the diagnosis of a non-vascular ulcer. Read More

    Successful Treatment of Disseminated Cutaneous Leishmaniasis With Liposomal Amphotericin B and Miltefosine in an Eight-year-old Girl.
    Pediatr Infect Dis J 2018 Mar;37(3):275-277
    This case report presents an 8-year-old girl, from Fars province in Iran, diagnosed with cutaneous leishmaniasis in the form of multiple nodular, ulcerative and crusted lesions disseminated on the face, trunk and extremities. The result of direct smear of ulcers was positive for Leishmania parasite. The patient had no immunodeficiency or relevant family history making her susceptible for disseminated cutaneous leishmaniasis. Read More

    Targeting the folate receptor: improving efficacy in inorganic medicinal chemistry.
    Curr Med Chem 2018 Feb 9. Epub 2018 Feb 9.
    The Centre for Biomimetic & Therapeutic Research, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8. Ireland.
    The discovery of the high-affinity, high-specificity folate receptor in mamalian kidney cells, coupled with the ability of folate to enter cells by folate receptor-mediated endocytosis and the subsequent elucidation of the folate receptor's overexpression in specific cancer cell types; heralded the arrival of the area of chemotherapeutic folate targeting. The application of purely organic folate-based small-molecule drug conjugates that selectively target the folate receptor, which is over expressed in several diseases such as cancer, is well established. The application of inorganic folate-targeted drugs offers significant potential to expand and enhance this therapeutic approach. Read More

    Report of in vitro antileishmanial properties of Iberian macroalgae.
    Nat Prod Res 2018 Feb 9:1-5. Epub 2018 Feb 9.
    a Centre of Marine Sciences , University of Algarve , Faro , Portugal.
    Here is reported the anti Leishmania infantum activity of 48 hexane, CHCland MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CHClCystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC29.8-101. Read More

    Andrographolide engineered gold nanoparticle to overcome drug resistant visceral leishmaniasis.
    Artif Cells Nanomed Biotechnol 2018 Feb 8:1-12. Epub 2018 Feb 8.
    d Department of Pharmaceutical Technology , Adamas University , Kolkata , India.
    Visceral leishmaniasis (VL) is World Health Organization designated most serious leishmaniasis with an annual mortality rate of 50,000. Even after country specific eradication programs, the disease continues to multiply with added complexities like resistance development, drug hypersensitivity and associated infections. Newer therapeutic interventions are urgently warranted to control the spread. Read More

    Glycoproteins in circulating immune complexes are biomarkers of patients with Indian PKDL: A study from endemic districts of West Bengal, India.
    PLoS One 2018 8;13(2):e0192302. Epub 2018 Feb 8.
    Department of Laboratory Medicine, School of Tropical Medicine, West Bengal, India.
    Background: Post Kala Azar Dermal Leishmaniasis (PKDL) occurs as dermal consequence of previous Visceral Leishmaniasis (VL) infection and serves as an important reservoir for transmission of VL. Diagnosis of PKDL is often challenging for its symptomatic resemblance to other co-endemic diseases like Leprosy or Vitiligo. Parasitological examination by slit-skin smear and culture are the standard methods but lack high sensitivity. Read More

    Comparing the Efficacy of Low Dose and Conventional Dose of Oral Isotretinoin in Treatment of Moderate and Severe Acne Vulgaris.
    J Res Pharm Pract 2017 Oct-Dec;6(4):233-238
    Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne.

    Methods: This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The patients were divided into two treatment groups: 0. Read More

    Efficacy of Intense-pulsed Light Therapy with Topical Benzoyl Peroxide 5% versus Benzoyl Peroxide 5% Alone in Mild-to-moderate Acne Vulgaris: A Randomized Controlled Trial.
    J Res Pharm Pract 2017 Oct-Dec;6(4):199-205
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: Acne vulgaris is a disease of pilosebaceous unit with multifactorial pathogenesis and threats patients' social functioning. There is a growing research to find faster, more effective, and easy to use treatments. The aim of this study is to evaluate the efficacy of benzoyl peroxide 5% (BP) with and without concomitant intense-pulsed light (IPL) therapy in mild-to-moderate acne vulgaris. Read More

    New Thiophene-Acridine Compounds: Synthesis, Antileishmanial Activity, DNA Binding, Chemometric and Molecular Docking Studies.
    Chem Biol Drug Des 2018 Feb 7. Epub 2018 Feb 7.
    Laboratório de Síntese e Vetorização de Moléculas, Universidade Estadual da Paraíba, Departamento de Ciências Biológicas, CEP 58070-450, João Pessoa, PB, Brazil.
    In the present study, we synthesized eight new compounds containing the 2-amino-cycloalkyl[b]thiophene and acridine moieties (ACTand ACS-ACS). None tested compounds presented human erythrocyte cytotoxicity. The new compounds presented antipromastigote activity, where ACSand ACSderivatives presented significant antileishmanial activity, with better performance than the reference drugs (tri and pentavalent antimonials), with respective ICvalues of 9. Read More

    Cutaneous Leishmaniasis in the Metropolitan City of Multan, Pakistan, a Neglected Tropical Disease.
    J Med Entomol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA.
    Cutaneous leishmaniasis is a vector-borne infection caused by flagellated parasitic protozoans in the genus Leishmania. Promastigotes are the infective stage, which are transmitted by the bite of female sand flies of the genera Phlebotomus or Lutzomyia. Three clinical forms of Leishmania infection are recognized in humans, and they are caused by different Leishmania species. Read More

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