29,788 results match your criteria Leishmaniasis


The Role of CD1a expression in the diagnosis of cutaneous leishmaniasis, its relationship with Leishmania species and clinicopathological features.

Dermatol Ther 2021 May 15. Epub 2021 May 15.

Department of Medical Biology and Genetics, Mersin University, School of Medicine, Mersin, Turkey.

Cutaneous leishmaniasis is caused by a flagellated protozoan transmitted by the bite of a female sandfly. The clinical and demographic details of this disease, predominantly affecting immunocompetent individuals, are recognized by the WHO as a Neglected Tropical Disease. We sought to determine the usability of CD1a immunohistochemical staining to detect amastigotes especially in cases where leishmaniasis is suspected but evident amastigotes could not observed. Read More

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Platelet-rich plasma versus carboxytherapy for the treatment of periocular hyperpigmentation; which approach is superior?

Dermatol Ther 2021 May 14:e14980. Epub 2021 May 14.

Dermatology Department, Skin Diseases and Leishmaniasis Research Center, Isfahan University of medical sciences, Isfahan, Iran.

Periorbital hyperpigmentation (POH) is a common aesthetic condition causing people referring to dermatology clinics. Although the therapeutic approach is steeply dependent to the etiology of POH, the gold standard approach of treatment is still a question. The current study is designed to compare the use of carboxytherapy vs platelet-rich plasma (PRP) for the treatment of POH. Read More

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Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes.

Microbiol Res 2021 May 6;249:126784. Epub 2021 May 6.

Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India. Electronic address:

Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a million people each year. The rising inefficacy of conventional therapeutics to combat these diseases, mainly due to the development of drug resistance to a handful of available licensed options contributes substantially to the rising burden of these ailments. Cysteine proteases are omnipresent enzymes that are critically implicated in the pathogenesis of protozoic infections. Read More

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Cutaneous Leishmaniasis Outbreak Investigation in Hajjah Governorate, Yemen, in 2018: Case-Control Study.

JMIR Public Health Surveill 2021 May 14;7(5):e27442. Epub 2021 May 14.

Department of Public Health, Community Medicine and Family Medicine, Faculty of Medicine, Jordan University of Science & Technology, Amman, Jordan.

Background: Cutaneous leishmaniasis (CL) is endemic in Yemen. About 4440 cases were reported in 2019. On July 23, 2018, a Hajjah governorate surveillance officer notified the Ministry of Public Health and Population about an increase in the number of CL cases in Bani-Oshb, Kuhlan district, Hajjah governorate. Read More

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Platelet-rich Plasma use for facial rejuvenation: a clinical trial and review of current literature.

Acta Biomed 2021 May 12;92(2):e2021187. Epub 2021 May 12.

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Background And Aim Of The Work: Several studies have shown beneficial effects for Platelet-rich plasma (PRP). We aimed to assess the efficacy of pure PRP injection for facial rejuvenation in Iran.

Methods:  30 female consecutive participants were injected with PRP in two sessions with 3 month interval. Read More

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A novel antigen, otubain cysteine peptidase of Leishmania donovani improves serodiagnosis of visceral leishmaniasis and monitors treatment response.

Clin Infect Dis 2021 May 13. Epub 2021 May 13.

Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

Tests for visceral leishmaniasis (VL) are not uniformly effective for all endemic regions. A novel antigen, otubain cysteine peptidase (Ld-OCP) in serological assay showed comparable sensitivity with Indian VL sera and a prominent increase in sensitivity with Brazilian sera compared with rK39. Additionally, Ld-OCP demonstrated improvement in monitoring treatment response. Read More

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Systematic Evaluation of spp. Proteomes for Drug Discovery.

Front Chem 2021 27;9:607139. Epub 2021 Apr 27.

Bioinformatics Plataform, Microbiology Department, Instituto Aggeu Magalhães, Recife, Brazil.

Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million new cases each year, for which the available therapies have serious limitations. Therefore, it is extremely important to apply efficient and low-cost methods capable of selecting the best therapeutic targets to speed up the development of new therapies against those diseases. Read More

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Strengthening data collection for neglected tropical diseases: What data are needed for models to better inform tailored intervention programmes?

PLoS Negl Trop Dis 2021 May 13;15(5):e0009351. Epub 2021 May 13.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Oxford, United Kingdom.

Locally tailored interventions for neglected tropical diseases (NTDs) are becoming increasingly important for ensuring that the World Health Organization (WHO) goals for control and elimination are reached. Mathematical models, such as those developed by the NTD Modelling Consortium, are able to offer recommendations on interventions but remain constrained by the data currently available. Data collection for NTDs needs to be strengthened as better data are required to indirectly inform transmission in an area. Read More

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Effectiveness of vector control methods for the control of cutaneous and visceral leishmaniasis: A meta-review.

PLoS Negl Trop Dis 2021 May 13;15(5):e0009309. Epub 2021 May 13.

Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.

Elimination of visceral leishmaniasis (VL) in Southeast Asia and global control of cutaneous leishmaniasis (CL) and VL are priorities of the World Health Organization (WHO). But is the existing evidence good enough for public health recommendations? This meta-review summarises the available and new evidence for vector control with the aims of establishing what is known about the value of vector control for the control of CL and VL, establishing gaps in knowledge, and particularly focusing on key recommendations for further scientific work. This meta-review follows the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria, including (1) systematic reviews and meta-analyses (SRs/MAs) for (2) vector control methods and strategies and (3) for the control of CL and/or VL. Read More

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Melittin as a promising anti-protozoan peptide: current knowledge and future prospects.

AMB Express 2021 May 13;11(1):69. Epub 2021 May 13.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Protozoan diseases such as malaria, leishmaniasis, Chagas disease, and sleeping sickness still levy a heavy toll on human lives. Deplorably, only few classes of anti-protozoan drugs have thus far been developed. The problem is further compounded by their intrinsic toxicity, emergence of drug resistance, and the lack of licensed vaccines. Read More

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Androgenetic alopecia in women and men is not related to COVID-19 infection severity: A prospective cohort study of hospitalized COVID-19 patients.

J Eur Acad Dermatol Venereol 2021 May 12. Epub 2021 May 12.

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The ongoing outbreak of COVID-19 has posed significant threats to international health. The first biologic step of potential infectivity of COVID-19 is the priming of the spike proteins by transmembrane protease, serine 2 (TMPRSS2). TMPRSS2 cleave angiotensin converting enzyme 2 (ACE2) for augmented viral entry and thus is regarded as essential for viral spread and pathogenesis in the infected hosts . Read More

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Trends in the Epidemiology of Leishmaniasis in the City of Barcelona (1996-2019).

Front Vet Sci 2021 26;8:653999. Epub 2021 Apr 26.

Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain.

Leishmaniasis is a neglected zoonosis produced by 20 different flagellated parasites of the genus, a protozoan transmitted to humans and other vertebrates by the bite of dipteran insects of the subfamily. It is endemic in Mediterranean countries and the number of cases is expected to increase due to climate change and migration. Prioritizing public health interventions for prevention and control is essential. Read More

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Evaluation of Loopamp™ Detection Kit and Antigen ELISA for Post-Elimination Detection and Management of Visceral Leishmaniasis in Bangladesh.

Front Cell Infect Microbiol 2021 26;11:670759. Epub 2021 Apr 26.

Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

With reduced prevalence of visceral leishmaniasis (VL) in the Indian subcontinent (ISC), direct and field deployable diagnostic tests are needed to implement an effective diagnostic and surveillance algorithm for post-elimination VL control. In this regard, here we investigated the diagnostic efficacies of a loop-mediated isothermal amplification (LAMP) assay (Loopamp™ Detection Kit, Eiken Chemical CO., Ltd, Japan), a real-time quantitative PCR assay (qPCR) and the antigen ELISA (CLIN-TECH, UK) with different sampling techniques and evaluated their prospect to incorporate into post-elimination VL control strategies. Read More

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Secretory Mevalonate Kinase Regulates Host Immune Response and Facilitates Phagocytosis.

Front Cell Infect Microbiol 2021 26;11:641985. Epub 2021 Apr 26.

Department of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India.

secretes over 151 proteins during cultivation. Cellular functions of one such novel protein: mevalonate kinase is discussed here; signifying its importance in infection. Visceral Leishmaniasis is a persistent infection, caused by in Indian subcontinent. Read More

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Skin manifestations as potential symptoms of diffuse vascular injury in critical COVID-19 patients.

J Cutan Pathol 2021 May 12. Epub 2021 May 12.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.

As a respiratory viral infection caused by a novel coronavirus, COVID-19 became rapidly pandemic within a few months. Despite the wide range of manifestations and organ involvement in COVID-19 patients, the exact pathogenesis of severe and fatal types of COVID-19 and causes involved with the individual base of the disease is not yet understood. Several studies have reported clinical, laboratory and histopathological data in favor of vascular injury in multiple organs of critically ill patients with COVID-19 as a result of hyperactive immune response, inflammation and cytokine storm. Read More

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Evaluation of an active and early surveillance methodology for visceral leishmaniasis by molecular detection in road-killed wild fauna.

Rev Bras Parasitol Vet 2021 10;30(2):e027920. Epub 2021 May 10.

Departamento de Medicina Veterinária Preventiva, Universidade Estadual de Londrina - UEL, Londrina, PR, Brasil.

The present study aimed to evaluate a methodology for active surveillance of visceral leishmaniasis by detecting Leishmania DNA in organs of wild road-killed animals from November 2016 to October 2018 in the North of Paraná, Brazil. The collection points of road-killed wild animals were georeferenced. The animals were autopsied and samples of bone marrow, lymph node, liver, spleen, and ear skin were collected. Read More

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A systematic review of the histopathologic survey on skin biopsies in patients with Corona Virus Disease 2019 (COVID-19) who developed virus or drug-related mucocutaneous manifestations.

Exp Dermatol 2021 May 11. Epub 2021 May 11.

Department of Dermatology, Rasool Akram Medical Complex, Iran, University of Medical Sciences (IUMS), Tehran, Iran.

The mucocutaneous manifestations of Corona Virus Disease 2019 (COVID-19) logically may reflect systemic visceral involvements. These findings are visible and easy to approach like biopsies for exact histopathologic evaluations. This systematic review was conducted to collect the mucocutaneous histopathologic data of COVID-19 patients for future investigations and interpretations. Read More

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Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana.

mSystems 2021 May 11;6(3). Epub 2021 May 11.

Department of Biosciences, Durham University, Durham, United Kingdom.

Heat shock protein 90 (Hsp90) is a conserved molecular chaperone responsible for the folding and maturation of nascent proteins. Hsp90 is regarded as a master regulator of protein homeostasis in the cell, and its inhibition affects the functions of a large array of client proteins. The classical Hsp90 inhibitor tanespimycin has shown potent antileishmanial activity. Read More

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The thiol-based reduction of Bi(V) and Sb(V) anti-leishmanial complexes.

J Inorg Biochem 2021 Apr 29;221:111470. Epub 2021 Apr 29.

School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. Electronic address:

Low molecular weight thiols including trypanothione and glutathione play an important function in the cellular growth, maintenance and reduction of oxidative stress in Leishmania species. In particular, parasite specific trypanothione has been established as a prime target for new anti-leishmania drugs. Previous studies into the interaction of the front-line Sb(V) based anti-leishmanial drug meglumine antimoniate with glutathione, have demonstrated that a reduction pathway may be responsible for its effective and selective nature. Read More

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Genome mutations of the Turkish strain Leishmania infantum_TR01.

Infect Genet Evol 2021 May 8;92:104907. Epub 2021 May 8.

Ankara University Faculty of Veterinary Medicine, Department of Parasitology, Ankara, Turkey.

Purpose: Today, almost 15 years have passed since the whole genome sequence (WGS) of a Leishmania parasite was completed for the first time. However, information on the genetics of these parasites remains to be elucidated. Genome-based studies may contribute to control strategies for leishmaniasis. Read More

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Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

4Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.

Cutaneous leishmaniasis (CL) is often caused by Leishmania braziliensis (L. braziliensis) in South America. Because of the risk for mucocutaneous leishmaniasis, L. Read More

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Detection of Cutaneous Leishmaniasis Foci in South Ethiopia.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

2Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium.

Cutaneous leishmaniasis (CL) is a major public health problem in Ethiopia. The disease is endemic in Ochollo, a village in southern Ethiopia, but there are no reports of CL in the wider area, although it is ecologically very similar. We conducted a rapid assessment survey in the South Ethiopian Rift Valley and found 100 parasitologically confirmed CL cases in 38 villages not reported endemic for CL. Read More

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Case Report: An Atypical Erysipeloid Presentation of Cutaneous Leishmaniasis from the Hilly Region of Nepal.

Authors:
Suman Nepal

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

Cutaneous leishmaniasis, which is the most common form of leishmaniasis, classically presents as small erythematous papules and nodules that develop into ulcers with indurated, raised outer borders. However, lesions of cutaneous leishmaniasis can have pleomorphic and atypical presentations. The erysipeloid form is one of the rare, atypical presentations of cutaneous leishmaniasis. Read More

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Liposomal amphotericin B is more effective in polymorphic lesions of post kala-azar dermal leishmaniasis.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-6. Epub 2021 Apr 23.

Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, India.

Background: Post kala-azar dermal leishmaniasis (PKDL) is thought to be the reservoir of infection for visceral leishmaniasis in South Asia. The development of strategies for the diagnosis and treatment of PKDL are important for the implementation of the visceral leishmaniasis elimination program.

Aims: Liposomal amphotericin B (L-AMB) has been an overwhelming success in the treatment of visceral leishmaniasis. Read More

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Involvement of Phosphatases in Parasite Biology and Pathogeny.

Front Cell Infect Microbiol 2021 22;11:633146. Epub 2021 Apr 22.

Instituto de Bioquímica Médica Leopoldo De Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

In the lifecycle, the motile promastigote form is transmitted from the sand fly vector to a mammalian host during a blood meal. Inside vertebrate host macrophages, the parasites can differentiate into the amastigote form and multiply, causing leishmaniasis, one of the most significant neglected tropical diseases. parasites face different conditions throughout their development inside sand flies. Read More

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Case Report: and HIV Co-Diagnosis: How to Understand Medical History?

Front Immunol 2021 21;12:669723. Epub 2021 Apr 21.

Infectious Diseases Department, Caen University Hospital, Caen, France.

We report a case of a severe visceral leishmaniasis revealing an HIV-1 infection presenting as an acute primary infection. A young French man living in Paris with history of unprotected sex with a recent male partner and recent travel in Greece was admitted in our Infectious Diseases Department, presenting with acute febrile psychotic disorder, and positive HIV-1 serology with high viral load, very low CD4 T-cells count and a western blot pattern suggesting an acute infection. The psychotic disorder was finally related to hemophagocytic lymphohistiocytosis diagnosed on bone marrow aspiration, supposedly secondary to HIV acute primary infection. Read More

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Nano- and Microformulations to Advance Therapies for Visceral Leishmaniasis.

ACS Biomater Sci Eng 2021 May 14;7(5):1725-1741. Epub 2020 Oct 14.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Visceral leishmaniasis (VL) is a deadly, vector-borne, neglected tropical disease endemic to arid parts of the world and is caused by a protozoan parasite of the genus . Chemotherapy is the primary treatment for this systemic disease, and multiple potent therapies exist against this intracellular parasite. However, several factors, such as systemic toxicity, high costs, arduous treatment regimen, and rising drug resistance, are barriers for effective therapy against VL. Read More

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Genus Triplaris (Polygonaceae): A review on traditional medicinal use, phytochemistry and biological activities.

J Ethnopharmacol 2021 May 6:114188. Epub 2021 May 6.

Laboratório de Farmacognosia e Fitoterapia (LFF) - Universidade Federal do Vale do São Francisco, Petrolina, PE, Brazil; Rede Nordeste de Biotecnologia (RENORBIO) - Universidade Federal Rural de Pernambuco, Recife, PE, Brazil. Electronic address:

Ethnopharmacological Relevance: The genus Triplaris (Polygonaceae) comprises approximately 25 species distributed throughout South and Central America. Some species have been used in folk medicine, mainly, to treat malaria, leishmaniasis, diarrheia, dysenteria, pain and inflammation.

Aim Of The Study: The purpose of this review is to provide information on the traditional uses, phytochemistry and known biological activities of Triplaris, an important genus for South America research groups on medicinal plants, in order to explore its therapeutic potential to direct future research in the search for new bioactive molecules. Read More

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Interdependencies between Toll-Like Receptors in Leishmania infection.

Immunology 2021 May 8. Epub 2021 May 8.

Tripura University, Agartala, Tripura, India.

Multiple pathogen-associated molecular patterns (PAMPs) on a pathogen's surface imply their simultaneous recognition by the host cell membrane-located multiple PAMP-specific Toll-Like Receptors (TLRs). The TLRs on endosomes recognize internalized pathogen-derived nucleic acids and trigger anti-pathogen immune responses aimed at eliminating the intracellular pathogen. Whether the TLRs influence each others expression and effector responses- termed TLRs inter-dependency- remains unknown. Read More

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Antileishmanial activity evaluation of a natural amide and its synthetic analogs against Leishmania (V.) braziliensis: an integrated approach in vitro and in silico.

Parasitol Res 2021 May 8. Epub 2021 May 8.

Federal University of Rondônia - UNIR, Porto Velho, Rondônia, Brazil.

Leishmaniasis is considered a neglected disease, which makes it an unattractive market for the pharmaceutical industry; hence, efforts in the search for biologically active substances are hampered by this lack of financial motivation. Thus, in the present study, we report the leishmanicidal activity and the possible mechanisms of action of compounds with promising activity against the species Leishmania (V.) braziliensis, the causative agent of the skin disease leishmaniasis. Read More

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