26,683 results match your criteria Leishmaniasis


Virulence factor RNA transcript expression in the subgenus: influence of species, isolate source, and RNA virus-1.

Trop Med Health 2019 11;47:25. Epub 2019 Apr 11.

1Institute of Medical Sciences, University of Toronto, Toronto, ON Canada.

Background: RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20-25% of -species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time. Our objective was to quantify known virulence factor (VF) RNA transcript expression according to LRV1 status, causative species, and isolate source.

Methods: Eight cultured isolates of were used, four of which were LRV1-positive ( [ = 1], . Read More

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http://dx.doi.org/10.1186/s41182-019-0153-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458769PMC

Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis.

Exp Parasitol 2019 Apr 17. Epub 2019 Apr 17.

Laboratório de Farmacologia e Imunologia- Universidade Federal de Alagoas, Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Av. Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP:57072-900, Maceió - AL, Brazil; Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR)(3). Universidade Federal do Rio de Janeiro, Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio(®))(4) CCS, Cidade Universitária, P.O. Box 68024, ZIP, 21941-971, Rio de Janeiro-RJ, Brazil. Electronic address:

In the present study, we investigated the in vitro and in vivo leishmanicidal activity of synthetic compounds, containing a semicarbazone scaffold as a peptide mimetic framework. The leishmanicidal effect against amastigotes of Leishmania amazonensis was also evaluated at concentration of 100 μM-0.01 nM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144894183038
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http://dx.doi.org/10.1016/j.exppara.2019.04.003DOI Listing
April 2019
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Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice.

Eur J Immunol 2019 Apr 18. Epub 2019 Apr 18.

INRS-Institut Armand Frappier and Center for Host-Parasite Interactions, 531 Boulevard des Prairies, Laval, H7V 1B7.

Visceral leishmanisiais, a chornic, potentially fatal disease, is characterized by high production of low-affinity antibodies. In humans, hypergammaglobulinemia is prediction of disease progression. Nevertheless, the contribution of hypermutated and/or class-switched immunoglobulins to disease pathogenesis has never been studied. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184791
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http://dx.doi.org/10.1002/eji.201847917DOI Listing
April 2019
1 Read

Neutrophil properties in healthy and Leishmania infantum-naturally infected dogs.

Sci Rep 2019 Apr 18;9(1):6247. Epub 2019 Apr 18.

Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-970, Rio de Janeiro, RJ, Brazil.

Visceral leishmaniasis is a chronic disease that affects humans and dogs as well. Dogs, the domestic reservoir of Leishmania, play a central role in the transmission of visceral leishmaniasis, the most severe form of this disease. Neutrophils are the most abundant leukocytes in blood and interact with the parasite after infection. Read More

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http://www.nature.com/articles/s41598-019-42687-9
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http://dx.doi.org/10.1038/s41598-019-42687-9DOI Listing
April 2019
1 Read

Direct-acting antivirals and visceral leishmaniasis: a case report.

BMC Infect Dis 2019 Apr 18;19(1):328. Epub 2019 Apr 18.

Dipartimento di Scienze per la promozione della Salute e Materno-infantile, Università di Palermo, Palermo, Italy.

Background: Visceral leishmaniasis is a vector-borne parasitic disease caused by protozoa belonging to the genus Leishmania. The clinical presentation of visceral leishmaniasis strictly depends on the host immunocompetency, whereas depressive conditions of the immune system impair the capability to resolve the infection and allow reactivation from sites of latency of the parasite.

Case Presentation: We describe a case of visceral leishmaniasis (VL) that occurred in a patient with chronic hepatitis C treated with direct-acting antiviral drugs (DAA). Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3947-xDOI Listing
April 2019
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Efficacy of miltefosine compared with glucantime for the treatment of cutaneous leishmaniasis: a systematic review and meta-analysis.

Epidemiol Health 2019 Mar 31:e2019011. Epub 2019 Mar 31.

Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: The objective of this paper is a systematic review and meta-analysis of clinical trials that compared the efficacy of miltefosine and glucantime in the treatment of Cutaneous leishmaniasis (CL).

Methods: We searched the following databases: Cochrane, PubMed, Embase, Scopus, Web of Science, ProQuest, CENTRAL, ICTRP, Sid, irandoc, magiran, and clinicaltrials.gov. Read More

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http://dx.doi.org/10.4178/epih.e2019011DOI Listing

Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: an insight for dendritic cells based vaccine.

Immunol Lett 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université Tunis El Manar, 13 Place Pasteur, BP 74, 1002 Tunis-Belvedère, Tunisia. Electronic address:

We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183041
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http://dx.doi.org/10.1016/j.imlet.2019.04.001DOI Listing
April 2019
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Leishmaniasis in Istanbul; A new epidemiological data about refugee leishmaniasis.

Acta Trop 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Leishmania is an intracellular parasite, which is transmitted by the bite of infected female Phlebotominae sand flies. Turkey is a crossroad between Europe and Asia that makes it important in terms of epidemiology. In the present study, we aimed to evaluate Leishmania infection among non-autochthonous patients admitted to Health Sciences University, Dr. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X193037
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http://dx.doi.org/10.1016/j.actatropica.2019.04.008DOI Listing
April 2019
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Dermatological Implications of Galectin-3 in Circulation: An Evaluation From the Perspective of Patients With Differential Manifestations of Post-Kala-Azar Dermal Leishmaniasis.

Am J Dermatopathol 2019 Apr 10. Epub 2019 Apr 10.

Departments of Laboratory Medicine, and.

Galectin-3, a β-galactoside-binding lectin, has been implicated in vast repertoire of inflammatory and immunomodulatory processes including skin diseases. However, galectin-3 has not been comprehensively studied in infectious diseases. This study emphasizes on fascinating aspects of galectin-3 expression in dermal infection by studying post-kala-azar dermal leishmaniasis (PKDL), an intracellular infection caused by Leishmania donovani. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001412DOI Listing

High resolution melting analysis as an accurate method for identifying in canine serum samples.

J Vector Borne Dis 2018 Oct-Dec;55(4):315-320

Department of Medical Parasitology and Mycology, School of Public Health, Tehran, Iran.

Background & Objectives: Leishmania (L.) infantum is the principal agent of visceral leishmaniasis (VL) in the Mediterranean and American regions. So far different molecular methods including high resolution melting (HRM) analysis have been developed for detecting and identifying L. Read More

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http://dx.doi.org/10.4103/0972-9062.256568DOI Listing
April 2019
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Modeling spatial distribution of as the main reservoir host of zoonotic cutaneous leishmaniasis in northeastern Iran.

J Vector Borne Dis 2018 Oct-Dec;55(4):297-304

Department of Epidemiology and Biostatistics, Kerman University of Medical Sciences, Kerman, Iran.

Background & Objectives: Zoonotic cutaneous leishmaniasis (ZCL) is among the most endemic zoonotic diseases in Golestan Province of Iran. The aim of this study was to find the high risk areas of this infection by considering the distribution of reservoirs and human infection.

Methods: A cross-sectional study was conducted, in which Rhombomys opimus (Gerbils) were captured from different collection sites across the Golestan Province, Iran. Read More

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http://dx.doi.org/10.4103/0972-9062.256565DOI Listing
April 2019
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Activated cytotoxic T cells within zoonotic cutaneous leishmaniasis lesions.

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Transmission, Control and Immunobiology of Infections, Pasteur Institute of Tunis, Tunis, Tunisia.

Introduction: Zoonotic cutaneous leishmaniasis (ZCL), due to infection by Leishmania (L). major, is characterized by polymorphic clinical manifestations which could be attributed to the host's immune response. In this study we investigated the involvement of cytotoxic cells on the outcome of the disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iid3.240
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http://dx.doi.org/10.1002/iid3.240DOI Listing
April 2019
2 Reads

-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis.

ACS Med Chem Lett 2019 Apr 27;10(4):413-418. Epub 2018 Nov 27.

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino (Firenze), Italy.

and Leishmania spp. are protozoa of the Trypanosomatidae family, respectively, responsible of the neglected tropical disorders (NTDs) Chagas disease and leishmaniasis. The present pharmacotherapy is often ineffective and exhibits serious side effects. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466549PMC

Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007313. Epub 2019 Apr 17.

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Leishmaniasis is a zoonotic disease of worldwide relevance. Visceral leishmaniasis is endemic in Brazil, where it is caused by Leishmania infantum with Lutzomyia longipalpis being the most important invertebrate vector. Non-human primates are susceptible to L. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007313DOI Listing

Identification of dehydroxy isoquine and isotebuquine as promising antileishmanial agents.

Arch Pharm (Weinheim) 2019 Apr 17:e1800281. Epub 2019 Apr 17.

Laboratorio de Ingeniería Genética, Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.

Traditional antimalarial drugs based on 4-aminoquinolines have exhibited good antiproliferative activities against Leishmania parasites; however, their clinical use is currently limited. To identify new 4-aminoquinolines to combat American cutaneous leishmaniasis, we carried out a full in vitro evaluation of a series of dehydroxy isoquines and isotebuquines against two Leishmania parasites such as Leishmania braziliensis and Leishmania mexicana. First, the antiproliferative activity of the quinolines was studied against the promastigote forms of L. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.2018002
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http://dx.doi.org/10.1002/ardp.201800281DOI Listing
April 2019
2 Reads

First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination?

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180323. Epub 2019 Apr 11.

Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil.

We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. Read More

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http://dx.doi.org/10.1590/0037-8682-0323-2018DOI Listing

Cost-effectiveness analysis of diagnostic-therapeutic strategies for visceral leishmaniasis in Brazil.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180272. Epub 2019 Apr 11.

Instituto de Avaliação de Tecnologia em Saúde, Porto Alegre, RS, Brasil.

Introduction: Visceral leishmaniasis (VL) is fatal if not diagnosed and treated. This study aimed to estimate the cost-effectiveness of diagnostic-therapeutic alternatives for VL in Brazil.

Methods: A decision model estimated the life expectancy and costs of six diagnostic-therapeutic strategies. Read More

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http://dx.doi.org/10.1590/0037-8682-0272-2018DOI Listing

Use of pharmaceutical nanotechnology for the treatment of leishmaniasis.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180246. Epub 2019 Apr 11.

Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brasil.

Introduction: Leishmaniasis is a global public health concern. Currently available treatments are associated with considerable side effects. The use of nanotechnology has shown promise for improving efficacy and bioavailability and minimizing side effects. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0037-8682-0246-2018DOI Listing
April 2019
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Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180172. Epub 2019 Apr 11.

Divisão de Dermatologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Introduction: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce.

Methods: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases. Read More

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http://dx.doi.org/10.1590/0037-8682-0172-2018DOI Listing
April 2019
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The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180278. Epub 2019 Apr 11.

Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy.

Methods: For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical response. Read More

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http://dx.doi.org/10.1590/0037-8682-0278-2018DOI Listing
April 2019
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Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation.

Sci Rep 2019 Apr 16;9(1):6127. Epub 2019 Apr 16.

Centro de Biología Molecular "Severo Ochoa" (CSIC/UAM), Campus de Excelencia Internacional (CEI) UAM+CSIC, Universidad Autónoma de Madrid, Madrid, Spain.

Leishmania donovani is a unicellular parasite that causes visceral leishmaniasis, a fatal disease in humans. In this study, a complete assembly of the genome of L. donovani is provided. Read More

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http://dx.doi.org/10.1038/s41598-019-42511-4DOI Listing

A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division.

Sci Rep 2019 Apr 16;9(1):6114. Epub 2019 Apr 16.

Centre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo, 01246-000, Brazil.

Leishmaniasis is a neglected disease that affects more than 12 million people, with a limited therapy. Plant-derived natural products represent a useful source of anti-protozoan prototypes. In this work, four derivatives were prepared from neolignans isolated from the Brazilian plant Nectandra leucantha, and their effects against intracellular amastigotes of Leishmania (L. Read More

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http://dx.doi.org/10.1038/s41598-019-42273-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467890PMC

Evaluation of antileishmanial drugs activities in an ex vivo model of leishmaniasis.

Parasitol Int 2019 Apr 13. Epub 2019 Apr 13.

Department of Animal Biology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil. Electronic address:

Leishmaniasis is a poverty-related disease, the chemotherapy of which is based on few drugs. The in vitro macrophage-amastigote model using mouse peritoneal cells, human-monocyte transformed macrophages and immortalized cell lines have been used to test new and safe antileishmanial drugs. Considering the differences for drug sensitivities between these Leishmania infected cells, the efficacy of amphotericin B, pentavalent antimonial, miltefosine and resveratrol was evaluated in a recently developed ex vivo culture of macrophages isolated from mouse lesion induced by L. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835769193003
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http://dx.doi.org/10.1016/j.parint.2019.04.011DOI Listing
April 2019
2 Reads

Progressive late-onset porokeratotic eccrine ostial and dermal duct naevus.

Australas J Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

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http://dx.doi.org/10.1111/ajd.13040DOI Listing

An HIV + patient with visceral enlarged lymph nodes.

Eur Clin Respir J 2019 1;6(1):1591843. Epub 2019 Apr 1.

Department of Respiratory Diseases & Allergy, Aarhus University Hospital, Aarhus, Denmark.

An HIV positive patient with enlarged visceral lymph nodes was diagnosed to be affected by visceral leishmaniasis. Transesophageal endoscopic ultrasound with fine needle aspiration, a diagnostic approach used when mediastinal or intra-abdominal lymphadenopathy is evident, was the first diagnostic test. Read More

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http://dx.doi.org/10.1080/20018525.2019.1591843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450598PMC

Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazoles and Indolizine Containing Compounds Flagged against Anti-Targets.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Institute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.

Due to the lack of approved vaccines against human leishmaniasis and the limitations of the current chemotherapy inducing side effects and drug resistance, development of new, effective chemotherapeutic agents is essential. This study describes the synthesis of a series of novel oxadiazoles and indolizine-containing compounds. The compounds were screened in silico using an EIIP/AQVN filter followed by ligand-based virtual screening and molecular docking to parasite arginase. Read More

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https://www.mdpi.com/1420-3049/24/7/1282
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http://dx.doi.org/10.3390/molecules24071282DOI Listing
April 2019
3 Reads

Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.

PLoS One 2019 15;14(4):e0215408. Epub 2019 Apr 15.

Department of Veterinary Public Health Safety and Management, Chinese Academy of Agricultural Sciences, Beijing, China.

Cathepsin L (CTSL) has been proved to help contain leishmaniasis and mycoplasma infection in mice by supporting cellular immune responses, but the regulatory functions of CTSL on mucosal immune responses haven't been tested and remain undefined. Here, we investigated the effects of CTSL on SIgA responses and invariant chain (Ii) degradations in the co-cultured swine dendritic cells (DCs) and B cells system in vitro. When the cells system were transfected with vector CTSL-GFP or incubated with recombinant CTSL (rCTSL) before they were infected with Mycoplasma hyopneumoniae (M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215408PLOS
April 2019
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An outbreak of cutaneous leishmaniasis among a displaced population in North Sudan: Review of cases.

J Family Med Prim Care 2019 Feb;8(2):556-563

Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.

Background: Human cutaneous leishmaniasis (CL) is an endemic disease in many parts of Sudan.

Objective: To document an outbreak of CL among internally displaced people (IDP) in north Sudan.

Methods: A household survey was conducted in the rural region of New Manasir, at El Damer Locality in north Sudan during the year 2013. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_432_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436281PMC
February 2019
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Chronic Relapsing Cutaneous Leishmaniasis in an Elderly Female: A Rare Clinical Presentation from a Nonendemic Area.

Indian Dermatol Online J 2019 Mar-Apr;10(2):165-167

Department of Dermatology and STDs, Government Medical College, Srinagar, J and K, India.

The presentation of cutaneous leishmaniasis (CL) varies from asymptomatic erythematous papules to nodulo-ulcerative forms over the exposed parts of body, generally healing slowly in 3-12 months. Besides, rare and atypical presentations of disease are being reported that pose both a diagnostic and therapeutic challenge especially in nonendemic areas. There has been an increase in the incidence of CL in our region over the past decade, and most of our patients belong to district Kupwara which is the north-most district of Kashmir valley, situated at an altitude of 5300 feet above sea level sharing borders with Pakistan-administered Kashmir. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_264_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434751PMC

Tocopherol biosynthesis in (.) promastigotes.

FEBS Open Bio 2019 Apr 5;9(4):743-754. Epub 2019 Mar 5.

Department of Parasitology Institute of Biomedical Sciences University of São Paulo Brazil.

Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus . Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug-resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Read More

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http://dx.doi.org/10.1002/2211-5463.12613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443866PMC
April 2019
2 Reads

[Leishmaniose].

Rev Prat 2019 Feb;69(2):178

60e antenne médicale, Valdahon, France.

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February 2019

Evaluation of Sexual Life and Marital Satisfaction in Patients with Anogenital Wart.

Actas Dermosifiliogr 2019 Apr 10. Epub 2019 Apr 10.

Centro de Investigación de Ciencias del Comportamiento y Psiquiatría, Universidad Mashhad de Ciencias Médicas, Mashhad, Irán. Electronic address:

Anogenital wart (AGW) resulting from human papilloma virus (HPV) is one of the most common sexually transmitted diseases worldwide. Herein, we aimed to evaluate the effects of AGW on patients'marital satisfaction and sexual function. This cross-sectional study was consisted of 74 consecutive patients including 37 patients with AGW and 37 healthy controls. Read More

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http://dx.doi.org/10.1016/j.ad.2018.08.005DOI Listing

Experimental Cutaneous Leishmaniasis: Mouse Models for Resolution of Inflammation Versus Chronicity of Disease.

Methods Mol Biol 2019 ;1971:315-349

Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.

Experimental cutaneous leishmaniasis of mice is a valuable model to study the immune response to the protozoan pathogen Leishmania and to define mechanisms of parasite control and resolution of inflammation as well as of parasite evasion and chronicity of disease. In addition, over many years Leishmania-infected mice have been successfully used to analyze the function of newly discovered immune cell types, transcription factors, cytokines, and effector mechanisms in vivo. In this chapter we present detailed protocols for the culture, propagation, and inoculation of Leishmania promastigotes, the monitoring of the course of cutaneous infection, the determination of the tissue parasite burden and for the phenotyping of the ensuing immune response. Read More

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http://link.springer.com/10.1007/978-1-4939-9210-2_18
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http://dx.doi.org/10.1007/978-1-4939-9210-2_18DOI Listing
January 2019
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Syrian Hamster as an Advanced Experimental Model for Visceral Leishmaniasis.

Methods Mol Biol 2019 ;1971:303-314

Department of Animal Health, ICPVet Research Group, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain.

Animal models are needed along the development and evaluation of potential chemotherapeutic agents against leishmaniasis. Infections of Syrian hamsters with Leishmania species causing visceral leishmaniasis (VL) closely mimic the disease in the natural hosts, including target organs, lesions, and clinical course. Therefore, despite some shortcomings (e. Read More

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http://link.springer.com/10.1007/978-1-4939-9210-2_17
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http://dx.doi.org/10.1007/978-1-4939-9210-2_17DOI Listing
January 2019
4 Reads

Quantification of Leishmania Parasites in Murine Models of Visceral Infection.

Methods Mol Biol 2019 ;1971:289-301

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Visceral leishmaniasis (VL) is mainly caused by Leishmania donovani (India and East Africa), and Leishmania infantum (Mediterranean Basin and South America) infections. Although murine models of visceral infection lack the clinicopathological aspects of VL in humans, they have been proven useful at advancing our knowledge in the Leishmania field. Indeed, these models have been used not only to better understand the pathophysiology of the infection but also in drug and vaccine development. Read More

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http://dx.doi.org/10.1007/978-1-4939-9210-2_16DOI Listing
January 2019

In Vitro Infections of Macrophage-Like Cell Lines with Leishmania infantum for Drug Screening.

Methods Mol Biol 2019 ;1971:265-277

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

The study of in vitro infections is essential to evaluate distinct aspects of Leishmania biology and also invaluable for more meaningful in vitro screening of promising chemical entities. Macrophage-like cells lines from different origins are amenable to Leishmania infection. Cell lines due to their stability and standardization potential are highly valued for their capacity to support reproducible infections and consistent data. Read More

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http://dx.doi.org/10.1007/978-1-4939-9210-2_14DOI Listing
January 2019

Health Considerations for HIV-Infected International Travelers.

Curr Infect Dis Rep 2019 Apr 12;21(5):16. Epub 2019 Apr 12.

Harvard Medical School, Boston, MA, USA.

Purpose Of The Review: International travel continues to steadily increase, including leisure travel, travel to one's country of origin to visit friends and relatives, travel for service work, and business travel. Travelers with HIV may have an increased risk for travel-associated infections. The pre-travel medical consultation is an important means of assessing one's risk for travel-related health issues. Read More

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http://dx.doi.org/10.1007/s11908-019-0672-yDOI Listing
April 2019
6 Reads

Identification of a peptide derived from a Bothrops moojeni metalloprotease with in vitro inhibitory action on the Plasmodium falciparum purine nucleoside phosphorylase enzyme (PfPNP).

Biochimie 2019 Apr 9;162:97-106. Epub 2019 Apr 9.

Center for the Study of Biomolecules Applied to Health, CEBio, Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, Rondônia, Brazil; Graduate Program in Experimental Biology, PGBIOEXP, Federal University of Rondônia, UNIR, Porto Velho, Rondônia, Brazil; National Institute of Science and Technology in Epidemiology of the Western Amazonia, INCT-EpiAmO, Porto Velho, Rondônia, Brazil; São Lucas University Center, UniSL, Porto Velho, Rondônia, Brazil.

There is a growing need for research on new antimalarial agents against Plasmodium falciparum infection, especially in regards to planning molecular architecture for specific molecular targets of the parasite. Thus, a metalloprotease from Bothrops moojeni, known as BmooMPα-I, was explored in this study, through in silico assays, aiming at the development of a peptide generated from this molecule with potential inhibitory action on PfPNP, an enzyme necessary for the survival of the parasite. In order to isolate BmooMPα-I, cation exchange and reverse phase chromatographies were performed, followed by in vitro assays of antiparasitic activity against the W2 strain of P. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.04.009DOI Listing
April 2019
2 Reads

Inventory and taxonomy of phlebotomine sand flies of the Mokolo leishmaniasis focus, northern Cameroon, with description of new Sergentomyia taxa (Diptera: Psychodidae).

Acta Trop 2019 Apr 9;194:172-180. Epub 2019 Apr 9.

Tropical Microbiology & Entomology Unit, Bundeswehr-Hospital Hamburg, Germany. Electronic address:

Leishmaniasis is endemic in northern Cameroon. However, the sand fly vectors have not been incriminated. A sand fly species inventory was generated by integrating a number of techniques. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.006DOI Listing

Label-free proteomic analysis reveals parasite-specific protein alterations in macrophages following Leishmania amazonensis, Leishmania major or Leishmania infantum infection.

ACS Infect Dis 2019 Apr 12. Epub 2019 Apr 12.

Leishmania is an obligate intracellular parasite known to modulate the host cell to survive and proliferate. However, the complexity of host-parasite interactions remains unclear. Also, the outcome of the disease has been recognized to be species-specific and dependent on the host`s immune responses. Read More

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http://dx.doi.org/10.1021/acsinfecdis.8b00338DOI Listing

Identification of priority areas for surveillance of cutaneous leishmaniasis using spatial analysis approaches in Southeastern Brazil.

BMC Infect Dis 2019 Apr 11;19(1):318. Epub 2019 Apr 11.

Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil.

Background: Cutaneous leishmaniasis (CL) is an important public health problem in Brazil and in several tropical regions of the world. In the Americas, Brazil is the country with the highest number of registered cases. In Brazil, the state of Minas Gerais has the highest number of cases in the southeastern region. Read More

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http://dx.doi.org/10.1186/s12879-019-3940-4DOI Listing

Cutaneous leishmaniasis among Syrian refugees in Jordan.

Acta Trop 2019 Apr 8;194:169-171. Epub 2019 Apr 8.

World Health Organization, Cairo, Egypt. Electronic address:

Introduction: Old World cutaneous leishmaniasis (CL) is one of the most prevalent vector-borne diseases within the World Health Organization's Eastern Mediterranean Region. The conflict in the Syrian Arab Republic generated large population movements and raised concerns about spreading of CL to countries where Syrians have relocated, including Jordan.

Methods: A review of electronic and paper-based registries of CL cases in Jordan was conducted to assess burden of disease and associated socio-demographic factors. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.005DOI Listing

Axenic amastigote cultivation and in vitro development of Leishmania orientalis.

Parasitol Res 2019 Apr 10. Epub 2019 Apr 10.

Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.

Leishmania (Mundinia) orientalis is a recently described new species that causes leishmaniasis in Thailand. To facilitate characterization of this new species, an in vitro culture system to generate L. orientalis axenic amastigotes was developed. Read More

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http://dx.doi.org/10.1007/s00436-019-06311-zDOI Listing

American Tegumentary Leishmaniasis in the Brazilian Amazon from 2010 to 2014.

Rev Inst Med Trop Sao Paulo 2019 8;61:e22. Epub 2019 Apr 8.

Universidade Federal do Amazonas, Escola de Enfermagem de Manaus, Manaus, Amazonas, Brazil.

American tegumentary leishmaniasis (ATL) is one of the most important but neglected infectious diseases, and can cause severe deformities. ATL incidence remains high in forest regions, such as in the Amazonas State, Brazil. However, differences within the State and over time have been observed, since infection patterns are not homogeneous, and these aspects need to be clarified. Read More

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http://dx.doi.org/10.1590/S1678-9946201961022DOI Listing

[Pancytopenia of unknown origin in a 52-year-old patient].

Internist (Berl) 2019 Apr 10. Epub 2019 Apr 10.

Klinik für Stammzelltransplantation, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

A 52-year-old patient developed pancytopenia of unknown origin 1.5 years after allogeneic stem cell transplantation. The bone marrow aspirate showed visceral leishmaniasis (VL). Read More

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http://link.springer.com/10.1007/s00108-019-0596-5
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http://dx.doi.org/10.1007/s00108-019-0596-5DOI Listing
April 2019
3 Reads

Cutaneous leishmaniasis: an evolving disease with ancient roots.

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Cutaneous leishmaniasis (CL) remains a prioritized neglected tropical disease. CL novel presentations call for updating its features.

Methods: A multiregional cohort of 396 patients with confirmed CL was reviewed. Read More

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http://dx.doi.org/10.1111/ijd.14451DOI Listing

-Host Interactions-An Epigenetic Paradigm.

Front Immunol 2019 22;10:492. Epub 2019 Mar 22.

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University, Madina, Saudi Arabia.

Leishmaniasis is one of the major neglected tropical diseases, for which no vaccines exist. Chemotherapy is hampered by limited efficacy coupled with development of resistance and other side effects. parasites elude the host defensive mechanisms by modulating their surface proteins as well as dampening the host's immune responses. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438953PMC

trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability.

Eur J Pharmacol 2019 Apr 6;853:275-288. Epub 2019 Apr 6.

Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Rod. Celso Garcia Cid PR445 Km 380, 86057-970, Londrina, Paraná, Brazil.

Leishmania parasites infect macrophages causing a wide spectrum of human diseases encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis treatment are highly toxic and associated with acquired resistance. Seeking novel therapeutic targets, we conducted a comprehensive in vitro study to investigate the action of trans-chalcone (TC) against Leishmania amazonensis promastigote and amastigote forms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193021
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http://dx.doi.org/10.1016/j.ejphar.2019.03.049DOI Listing
April 2019
2 Reads

Epidemiological features of a recent zoonotic cutaneous leishmaniasis outbreak in Zagora province, southern Morocco.

PLoS Negl Trop Dis 2019 Apr 9;13(4):e0007321. Epub 2019 Apr 9.

Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Maroc, Casablanca, Morocco.

Background: Leishmania major is an endemic vector-borne disease in Morocco that causes zoonotic cutaneous leishmaniasis (ZCL), especially in arid pre-Saharan regions where its unique vector and reservoir are Phlebotomus papatasi and Meriones shawi, respectively, and may cause epidemics. In late 2017, the Zagora province, an endemic focus for ZCL in southern Morocco, had CL outbreak. The main objective of our investigation was to analyze the epidemiological features of this latest ZCL outbreak. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007321DOI Listing
April 2019
1 Read

Comparative antileishmanial efficacy of the biosynthesised ZnO NPs from genus .

IET Nanobiotechnol 2018 Dec;12(8):1067-1073

Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan.

This study describes ZnO NPs biosynthesis using leaf extracts of and . The extracts serve as natural reducing, capping and stabilization facilitators. Plant extracts phytochemical analysis, revealed that showed higher total phenolic and flavonoid content (22. Read More

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http://dx.doi.org/10.1049/iet-nbt.2018.5076DOI Listing
December 2018