Limitations of current therapeutic options, possible drug targets and scope of natural products in control of leishmaniasis.
Mini Rev Med Chem 2017 Apr 24. Epub 2017 Apr 24.
Department of Biochemistry Institute of Science Banaras Hindu University Varanasi - 221 005. India.
Soon after the identification of Leishmania parasites,the pentavalent antimony compounds have been the mainstay to treat leishmanial infections, worldwide. These compounds were also considered true antileishmanial but the growing incidences of resistance have forced clinicians to use other options. However, due to unavailability of antileishmanial compounds, few drugs like pentamidine (antimicrobial), amphotericin B (antifungal) or miltefosine (antitumor) agents, which are associated with serious side effects, are currently being used. Read More