28,196 results match your criteria Leishmaniasis


Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American populations.

Acta Trop 2020 May 31:105546. Epub 2020 May 31.

Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, España. Electronic address:

The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in five independent Latin American cohorts. A total of 3,087 individuals from Latin American countries (Argentina, Bolivia, Peru, and two cohorts from Colombia) were studied. In all cohorts, patients were classified as seropositive for T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105546DOI Listing

Effects of forest degradation on the sand fly communities of northeast Brazil.

J Vector Ecol 2020 Jun;45(1):89-99

Laboratório de Entomologia e Vetores, Departamento de Biologia, Universidade Federal do Maranhão, Brazil.

The richness and abundance of sand fly species were studied in northeastern Brazil in areas of leishmaniasis transmission. The study was carried out in two forest areas with different deforestation times for agricultural and livestock activities: one modified by long-term settlement (more than 50 years of occupation) and another less impacted by short-term settlement (10 years). The sand flies were captured with CDC light traps from 18:00 to 06:00 for three consecutive nights, once a month, from May, 2012 to April, 2014. Read More

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http://dx.doi.org/10.1111/jvec.12376DOI Listing

Major environmental and socioeconomic determinants of cutaneous leishmaniasis in Brazil - a systematic literature review.

Rev Soc Bras Med Trop 2020 1;53:e20190291. Epub 2020 Jun 1.

Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Cutaneous leishmaniasis (CL) is a zoonotic disease with complex transmission cycle. Some environmental and socioeconomic factors are known to be the major determinants of the transmission process, which are involved in configuring the spatiotemporal patterns and thus can be delimiting. However, the relevance of these socioeconomic and environmental determinants is still not well understood. Read More

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http://dx.doi.org/10.1590/0037-8682-0291-2019DOI Listing

Canine leishmaniasis in the semi-arid region of Pernambuco, northeastern Brazil: epidemiology, factors associated with seropositivity and spatial analysis.

Rev Bras Parasitol Vet 2020 1;29(2):e001120. Epub 2020 Jun 1.

Laboratório de Doenças Parasitárias, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brasil.

This study aimed to determine the seroprevalence, factors associated with seropositivity to Leishmania infection in dogs and spatial analysis in six municipalities in the semiarid region of Pernambuco, Brazil. Blood samples were collected from 462 dogs, 77 in each municipality, and used for serological analysis [dual path platform (DPP®) and enzyme-linked immunosorbent assay (ELISA)]. Clinical signs of dogs were evaluated and associated factors for Leishmania infection were analyzed using robust Poisson regression model. Read More

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http://dx.doi.org/10.1590/s1984-29612020027DOI Listing

infection of the ear treated with photodynamic therapy.

JAAD Case Rep 2020 Jun 24;6(6):514-517. Epub 2020 Apr 24.

Department of Dermatology, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2020.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256222PMC

Visceral leishmaniasis with hemophagocytic lymphohistiocytosis (HLH).

IDCases 2020 12;21:e00804. Epub 2020 May 12.

Department of Laboratory Medicine and BloodBank, Aseer Central Hospital, Abha, Saudi Arabia.

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http://dx.doi.org/10.1016/j.idcr.2020.e00804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256657PMC

Shelter availability and human attitudes as drivers of rock hyrax () expansion along a rural-urban gradient.

Ecol Evol 2020 May 15;10(9):4044-4065. Epub 2020 Apr 15.

School of Zoology Tel Aviv University Tel Aviv Israel.

While anthropogenic land-use changes threaten wildlife globally, some species take advantage of such changes and disperse into urban areas. The wildlife in urban areas often promotes conflicts with humans, notably when the animals are associated with the spread of zoonotic diseases. In Israel, current urban invasion of rock hyraxes () draws public attention, since the species is a reservoir host of cutaneous leishmaniasis, a serious skin disease. Read More

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http://dx.doi.org/10.1002/ece3.6174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244799PMC

The rK39 Antigen from an Iranian Strain of : Detection of Anti- Antibodies in Humans and Dogs.

Iran J Parasitol 2020 Jan-Mar;15(1):48-56

Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Visceral leishmaniasis (VL) is the most severe form of leishmaniasis in Iran with high mortality rates in the case of inaccurate diagnosis and treatment. This study aimed to prepare and evaluate a new rk39 recombinant antigen from an Iranian strain of for diagnosis of VL in humans and dogs.

Methods: rK39-based enzyme-linked immunosorbent assay (ELISA) was compared with the direct agglutination test (DAT) for the detection of anti antibodies. Read More

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Frequency and Molecular Identification of Species among Immunocompromised Patients Referred to Hospitals, Central Iran, 2015-16.

Iran J Parasitol 2020 Jan-Mar;15(1):31-39

Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The purpose of this study was to determine the prevalence and genotype of spp. in different groups of immunocompromised patients admitted to the referral hospitals in center of Iran during 2015-2016.

Methods: This cross-sectional study was conducted on 346 immunocompromised patients (HIV/AIDS, Lymphoma, Leukemia and organ transplants) in referred hospitals from central parts of Iran including Isfahan, Markazi, Yazd and Chaharmahale Bakhtiari provinces. Read More

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Design, Construction and Immunogenicity Assessment of pEGFP-N1-KMP11-GP96 (Fusion) as a DNA Vaccine Candidate against Infection in BALB/c Mice.

Iran J Parasitol 2020 Jan-Mar;15(1):11-21

Department of Parasitology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.

Background: KMP-11 (Kinetoplastid membrane protein-Π) exists in all species of kinetoplastid family. It is fully conserved and the protein produced by this gene can induce a very high cellular immune response. We aimed to design a suitable construction for a DNA vaccine and evaluate the protective efficacy of it as a candidate for DNA vaccine against cutaneous leishmaniasis in BALB/c mice. Read More

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Evaluation of clinical and demographic characteristics of Turkish and Syrian pediatric cutaneous leishmaniasis patients from Hatay, Turkey after the Syrian civil war.

Postepy Dermatol Alergol 2020 Apr 11;37(2):229-233. Epub 2018 Dec 11.

Department of Biostatistics, Faculty of Medicine, Mustafa Kemal University, Hatay/Antakya, Turkey.

Introduction: Cutaneous leishmaniasis (CL) is a skin disease affecting all ages but especially children. Cutaneous leishmaniasis exists in Turkey, and, especially together with emigration from Syria to Turkey in recent years due to the civil war in Syria, the incidence of the disease has increased.

Aim: To investigate Syrian patients (SP) and Turkish patients (TP) in the pediatric age group who were diagnosed with CL and to compare the age, gender, clinical type, number of lesions, and lesion localizations of these patients. Read More

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http://dx.doi.org/10.5114/ada.2018.79729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262808PMC

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity.

Molecules 2020 May 30;25(11). Epub 2020 May 30.

Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP 13083-970, Brazil.

High genetic and phenotypic variability between species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse species can be useful in enabling compound prioritization based on their spectrum of activity. In this study, a robust and reproducible high content assay was developed, and 1280 small molecules were simultaneously screened against clinically relevant cutaneous and visceral species: , , and . Read More

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http://dx.doi.org/10.3390/molecules25112551DOI Listing

Differentiation of (.) , (.) and (.) Using Sequential qPCR Assays and High-Resolution Melt Analysis.

Microorganisms 2020 May 29;8(6). Epub 2020 May 29.

Department of Biomolecular Sciences, University of Urbino "Carlo Bo", 61029 Urbino (PU), Italy.

protozoa are the etiological agents of visceral, cutaneous and mucocutaneous leishmaniasis. In specific geographical regions, such as Latin America, several species are endemic and simultaneously present; therefore, a diagnostic method for species discrimination is warranted. In this attempt, many qPCR-based assays have been developed. Read More

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http://dx.doi.org/10.3390/microorganisms8060818DOI Listing

Biotechnological applications from a Leishmania amastigote-specific hypothetical protein in the canine and human visceral leishmaniasis.

Microb Pathog 2020 May 30:104283. Epub 2020 May 30.

Programa de Pós-Graduação Em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil. Electronic address:

The treatment against visceral leishmaniasis (VL) presents problems, mainly related to the toxicity and/or high cost of the drugs. In this context, a rapid and precise diagnosis of the disease should be performed, mainly to treat patients as soon as possible, aiming to reduce the treatment time and the toxicity of the therapeutics. In the present study, the diagnostic role of an amastigote-specific Leishmania protein was evaluated in the canine and human VL. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104283DOI Listing

Oral delivery and enhanced efficacy of antimonal drug through macrophage-guided multifunctional nanocargoes against visceral Leishmaniasis.

Eur J Pharm Biopharm 2020 May 30. Epub 2020 May 30.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address:

The present study aimed on the site specific delivery and enhanced in-vivo efficacy of antimonial drugs against the visceral leishmaniasis via macrophage targeted mannose anchored thiomer based nanoparticles. Mannose anchored thiolated nanoformulation [M-(CS-g-PEI)-TGA] was developed and evaluated in terms particle size, zeta-potential and entrapment efficacy. The TEM and EDX analysis was carried out to evaluate the morphology and successful entrapment of antimonial drug. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.05.029DOI Listing

The limited knowledge of placental damage due to neglected infections: ongoing problems in Latin America.

Syst Biol Reprod Med 2020 Jun;66(3):151-169

Laboratory of Vascular Biology and Histopathology, Institute of Health Sciences and Health, Federal University of Mato Grosso , Barra Do Garcas, Brazil.

The placenta works as a selective barrier, protecting the fetus from potential infections that may affect the maternal organism during pregnancy. In this review, we will discuss several challenging infections that are common within Latin American countries and that may affect the maternal-fetal interface and pose risks to fetal development. Specifically, we will focus on emerging infectious diseases including the arboviruses, malaria, leishmaniasis, and the bacterial foodborne disease caused by Shiga toxin-producing . Read More

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http://dx.doi.org/10.1080/19396368.2020.1753850DOI Listing

Cutaneous Leishmaniasis in Harrankapı, Şanlıurfa.

Authors:
İlhan Akaslan

Turkiye Parazitol Derg 2020 Jun;44(2):124-125

Biruni Üniversitesi Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Turkiye.

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http://dx.doi.org/10.4274/tpd.galenos.2020.6750DOI Listing

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts.

PLoS Pathog 2020 Jun 1;16(6):e1008291. Epub 2020 Jun 1.

Institut National de la Recherche Scientifique (INRS)-Centre Armand-Frappier Santé Biotechnologie (CAFSB), Laval, Quebec, Canada.

The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a chronic infection which is fatal when untreated. Herein, we investigated whether in addition to altering transcription, L. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008291DOI Listing

Prevalence of Cutaneous Leishmaniasis in Iran (2000-2016): A Systematic Review and Meta-analysis Study.

Infect Disord Drug Targets 2020 Jun 1. Epub 2020 Jun 1.

Parasitology department, school of medicine, Ilam university of medical sciences, Ilam. Iran.

Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis affecting humans. The purpose of this study was to determine the prevalence and epidemiological features of CL in Iran by a systematic review and meta-analysis. The literature search was performed in the SID, Magiran, IranDoc, PubMed, Scopus, Medlib, as well as the Google Scholar search engine databases to find studies on the prevalence of CL. Read More

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http://dx.doi.org/10.2174/1871526520666200601164850DOI Listing

Recalibration of insecticide-measuring containers could prevent underdosing of insecticide during indoor residual spraying for visceral leishmaniasis (kala-azar) elimination in India.

Trans R Soc Trop Med Hyg 2020 Jun 1. Epub 2020 Jun 1.

District Vector Borne Disease Control Office, Health Department, Government of Bihar, Sitamarhi, Bihar 843301, India.

Background: The visceral leishmaniasis (kala-azar) elimination programme in India relies on indoor residual spraying (IRS) for sand-fly vector control. Insecticide supplied by a new manufacturer was introduced for IRS in 2019. We aimed to explore whether this led to a change in insecticide quantity being used in the field. Read More

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http://dx.doi.org/10.1093/trstmh/traa026DOI Listing

An Unusual Presentation of Post kala-azar Dermal Leishmaniasis.

Indian Dermatol Online J 2020 Mar-Apr;11(2):269-271. Epub 2020 Mar 9.

Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_338_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247655PMC

RANK Ligand Helps Immunity to by Skewing M2-Like Into M1 Macrophages.

Front Immunol 2020 12;11:886. Epub 2020 May 12.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Macrophages host infection, which causes cutaneous Leishmaniasis in humans. In the murine model, resistance to infection depends on the host immunity mediated by CD4 T-cell cytokines and macrophages. In association to other stimuli, the Th1 cytokine IFN-γ induces NO-mediated microbial killing by M1/classically-activated macrophages. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235166PMC

Primary Immunodeficiencies in a Mesoregion of São Paulo, Brazil: Epidemiologic, Clinical, and Geospatial Approach.

Front Immunol 2020 12;11:862. Epub 2020 May 12.

Imunnodeficiencies Outpatient Clinic, Regional Hospital of Presidente Prudente, Presidente Prudente, Brazil.

Primary immunodeficiencies (PIDs) are rare genetic disorders leading to immunologic abnormalities that can affect different organs and systems. We determined the epidemiology, clinical, and geospatial characteristics of PID disorders among patients diagnosed over a 5 year period in a reference hospital covering a mesoregion in São Paulo, Brazil. A retrospective analysis of 39 patients with recognizable PIDs according to the criteria of the European Society of Primary Immunodeficiencies were enrolled. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235164PMC

Investigation of the antigenicity and protective efficacy of Leishmania promastigote membrane antigens in search of potential diagnostic and vaccine candidates against visceral leishmaniasis.

Parasit Vectors 2020 May 30;13(1):272. Epub 2020 May 30.

Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, West Bengal, India.

Background: Visceral leishmaniasis (VL), is a parasitic disease that causes serious medical consequences if treatment is delayed. Despite a decline in the number of VL cases in the Indian subcontinent, the commencement of the disease in newer areas continues to be a major concern. Although serological diagnosis mainly by immunochromatographic tests has been found to be effective, a test of cure in different phases of treatment is still desired. Read More

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http://dx.doi.org/10.1186/s13071-020-04138-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260476PMC

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi.

J Struct Biol 2020 May 27:107536. Epub 2020 May 27.

Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 - sala E-32, 21941-902 Rio de Janeiro, RJ, Brazil. Electronic address:

Complete genome sequencing of the kinetoplastid protozoans Trypanosoma cruzi, Trypanosoma brucei and Leishmania major (Tritryp), published in 2005, opened up new perspectives for drug development targeting Chagas disease, African sleeping sickness and Leishmaniasis, neglected diseases affecting millions of most economically disadvantaged people. Still, half of the Tritryp genes code for proteins of unknown function. Moreover, almost 50% of conserved eukaryotic protein domains are missing in the Tritryp genomes. Read More

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http://dx.doi.org/10.1016/j.jsb.2020.107536DOI Listing

Treatment of localized cutaneous leishmaniasis with intralesional meglumine antimoniate and photodynamic therapy.

Actas Dermosifiliogr 2020 May 27. Epub 2020 May 27.

Lisboa, Portugal (Consulta privada), Portugal.

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http://dx.doi.org/10.1016/j.ad.2020.02.004DOI Listing

Treatment of COVID-19 with pentoxifylline: Could it be a potential adjuvant therapy?

Dermatol Ther 2020 May 30. Epub 2020 May 30.

Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.

The world is facing a viral pandemic of a new coronavirus called COVID-19. Pentoxifylline is a methyl-xanthine and it inhibits phosphodiesterase IV (PDE IV). This drug is known for its unique features as an immunomodulatory and anti-inflammatory agent, also it could have antiviral affects. Read More

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http://dx.doi.org/10.1111/dth.13733DOI Listing

A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential anti-leishmanial drug candidate.

J Biol Chem 2020 May 29. Epub 2020 May 29.

CSIR-Indian Institute of Chemical Biology, India.

Emergence of resistance to available anti-leishmanial drugs advocates identification of new drug targets and their inhibitors for visceral leishmaniasis. Here, we identified heat shock protein 78 in (LdHSP78), a putative ClpB protease, as important for parasite infection of host macrophages and a potential therapeutic target. Enrichment of LdHSP78 in infected humans, hamsters and parasite amastigotes suggested its importance for disease persistence. Read More

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http://dx.doi.org/10.1074/jbc.RA120.014587DOI Listing

Chimeric Vaccines Designed by Immunoinformatics-Activated Polyfunctional and Memory T Cells That Trigger Protection against Experimental Visceral Leishmaniasis.

Vaccines (Basel) 2020 May 27;8(2). Epub 2020 May 27.

Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto 35400-000, Brazil.

Many vaccine candidates against visceral leishmaniasis (VL) have been proposed; however, to date, none of them have been efficacious for the human or canine disease. On this basis, the design of leishmaniasis vaccines has been constantly changing, and the use of approaches to select specific epitopes seems to be crucial in this scenario. The ability to predict T cell-specific epitopes makes immunoinformatics an even more necessary approach, as in VL an efficient immune response against the parasite is triggered by T lymphocytes in response to spp. Read More

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http://dx.doi.org/10.3390/vaccines8020252DOI Listing

Antileishmanial drugs activate inflammatory signaling pathways via toll-like receptors (docking approach) from Leishmania amazonensis-infected macrophages.

Int Immunopharmacol 2020 May 26;85:106640. Epub 2020 May 26.

Laboratório de Biotecnologia Aplicada à Saúde, Fundação Oswaldo Cruz (FIOCRUZ Rondônia), Porto Velho, RO, Brazil; Fundação Oswaldo Cruz (FIOCRUZ Ceará), Eusébio, CE, Brazil. Electronic address:

The activation of proinflammatory cellular processes and signals such as those linked to NF-kB in macrophages are involved in the control of infection by Leishmania ssp. However, little is known about the influence of the drugs used in the treatment on the host cellular inflammatory signaling pathways. This study aimed to evaluate the effects of different drugs used in the treatment of leishmaniasis on inflammatory profile related to Toll-like receptors (TLRs) from L. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106640DOI Listing

Entomological Survey for the Detection of Sand Fly Fauna and Vector Species in the Cutaneous Leishmaniasis Endemic Area in East Mediterranean Region of Turkey, Mersin Province.

J Med Entomol 2020 May 29. Epub 2020 May 29.

Department of Parasitology, Faculty of Medicine, Ege University, İzmir, Turkey.

Cutaneous (CL) and visceral (VL) forms of leishmaniasis, transmitted by sand flies, are seen in all countries located in Mediterranean Basin including Turkey. In this study, we aimed to conduct an entomological survey for the detection of sand fly fauna and vector species in Mersin province, one of the important endemic areas for CL in Turkey. In total, 912 sand fly specimens were collected in 2010 and 2011 using CDC light traps. Read More

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http://dx.doi.org/10.1093/jme/tjaa089DOI Listing

Cutaneous leishmaniasis with multiple ulcerated lesions in an immunocompetent patient caused by Leishmania major.

J Dtsch Dermatol Ges 2020 May 29. Epub 2020 May 29.

Department of Dermatology and Allergology, University Hospital of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/ddg.14112DOI Listing

Respiratory Diseases, Malaria and Leishmaniasis: Temporal and Spatial Association with Fire Occurrences from Knowledge Discovery and Data Mining.

Int J Environ Res Public Health 2020 May 25;17(10). Epub 2020 May 25.

Department of Geography, Federal University of Uberlândia, Uberlândia 38408-100, Brazil.

The relationship between the fires occurrences and diseases is an essential issue for making public health policy and environment protecting strategy. Thanks to the Internet, today, we have a huge amount of health data and fire occurrence reports at our disposal. The challenge, therefore, is how to deal with 4 Vs (volume, variety, velocity and veracity) associated with these data. Read More

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http://dx.doi.org/10.3390/ijerph17103718DOI Listing

Effect of El Niño Southern Oscillation cycle on the potential distribution of cutaneous leishmaniasis vector species in Colombia.

PLoS Negl Trop Dis 2020 May 28;14(5):e0008324. Epub 2020 May 28.

Grupo de Investigación Salud-Comunid-UDES, Programa de Medicina, Universidad de Santander, Bucaramanga, Santander, Colombia.

Local anomalies in rainfall and temperature induced by El Niño and La Niña episodes could change the structure of the vector community. We aimed to estimate the effect of the El Niño-La Niña cycle in the potential distribution of cutaneous leishmaniasis (CL) vector species in Colombia and to compare the richness of the vectors with the occurrence of CL in the state of Norte de Santander. The potential distributions of four species were modeled using a MaxEnt algorithm for the following episodes: La Niña 2010-2011, Neutral 2012-2015 and El Niño 2015-2016. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008324DOI Listing

Aptamers as a novel diagnostic and therapeutic tool and their potential use in parasitology

Biomedica 2020 05 1;40(Supl. 1):148-165. Epub 2020 May 1.

Instituto Colombiano de Medicina Tropical, Universidad CES, Medellín, Colombia.

Aptamers are single-stranded DNA or RNA sequences that adopt unique three-dimensional structures that allow them to recognize a specific target with high affinity. They can potentially be used for the diagnosis of diseases, as new therapeutic agents, for the detection of food risks, as biosensors, for the detection of toxins, and as drug carriers and nanoparticle markers, among other applications. To date, an aptamer called pegaptanib is the only aptamer approved by the Food and Drug Administration (FDA) for commercial use. Read More

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http://dx.doi.org/10.7705/biomedica.4765DOI Listing

In vitro effectivity of three approved drugs and their synergistic interaction against Leishmania infantum.

Biomedica 2020 05 1;40(Supl. 1):89-101. Epub 2020 May 1.

Medical Parasitology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Introduction: Leishmaniasis remains one of the neglected tropical diseases. Repurposing existing drugs has proven to be successful for treating neglected tropical diseases while combination therapy is a strategic alternative for the treatment of infectious diseases. Auranofin, lopinavir/ritonavir, and sorafenib are FDA approved drugs used in the treatment of diverse diseases by acting on different essential biological enzymes. Read More

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http://dx.doi.org/10.7705/biomedica.4891DOI Listing

Leishmaniasis en Bolivia. Comprehensive review and current status in Tarija, in the border with Argentina

Biomedica 2020 05 1;40(Supl. 1):45-61. Epub 2020 May 1.

Instituto Nacional Medicina Tropical, Puerto Iguazú, Misiones, Argentina.

Introduction: In the department of Tarija in the Bolivian-Argentine border, human cases with ulcers on uncovered parts of the skin plus clinical and epidemiological characteristics related to leishmaniasis were reported for the first time in 1997. Objective: To describe and to verify the presence of leishmaniasis in Tarija, sixth endemic department in Bolivia. Materials and methods: We conducted both an outbreak study (November, 1998, to December, 2002) and a longitudinal study (1997 to 2018) in humans, as well as captures of Phlebotominae and potential reservoirs. Read More

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http://dx.doi.org/10.7705/biomedica.4990DOI Listing

Variation of the Phlebotominae (Diptera: Psychodidae: Phlebotominae) Assemblage in Response to Land Use Changes in an Endemic Area of Leishmania Transmission in Northeast Argentina.

J Med Entomol 2020 May 28. Epub 2020 May 28.

Instituto Nacional de Medicina Tropical (INMeT), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS), Ministerio de Salud, y Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Puerto Iguazú , Argentina.

Leishmaniases are a global health problem and in Argentina are considered emerging diseases. The new transmission scenarios of tegumentary leishmaniasis are especially important given that large areas of forest are being transformed into rural and urban systems. The aim of this study was to analyze the impact of the construction of a large public building and a neighborhood on the assemblage of Phlebotominae in a rural area with forest remnants and to correlate the changes observed in the species assemblage with characteristics of the environment. Read More

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http://dx.doi.org/10.1093/jme/tjaa090DOI Listing

Antileishmanial activity evaluation of thiazolidine-2,4-dione against Leishmania infantum and Leishmania braziliensis.

Parasitol Res 2020 May 27. Epub 2020 May 27.

Departamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil.

Leishmaniasis is responsible for approximately 65,000 annual deaths. Despite the mortality data, drugs available for the treatment of patients are insufficient and have moderate therapeutic efficacy in addition to serious adverse effects, which makes the development of new drugs urgent. To achieve this goal, the integration of kinetic and DSF assays against parasitic validated targets, along with phenotypic assays, can help the identification and optimization of bioactive compounds. Read More

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http://dx.doi.org/10.1007/s00436-020-06706-3DOI Listing

Histopathology of Cutaneous Leishmaniasis Caused by in Sri Lanka.

Biomed Res Int 2020 2;2020:4926819. Epub 2020 May 2.

Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka.

Cutaneous leishmaniasis (CL) is a neglected tropical disease that is gaining importance in Sri Lanka and internationally. The clinical presentation, pathology, and method of parasite elimination in CL vary according to the species. is the causative organism for leishmaniasis in Sri Lanka. Read More

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http://dx.doi.org/10.1155/2020/4926819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222607PMC

Prevalence and Associated-Factors for in Adolescents in Southeastern Iran by Culture and PCR, 2017.

Iran J Public Health 2020 Feb;49(2):351-359

Department of Pediatric Dentistry, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.

Background: This study aimed to identify the prevalence and potential factors associated with in adolescents in the city of Kerman, southeastern Iran, 2017.

Methods: In this descriptive cross-sectional study, 315 adolescents (mean age; 15 yr) consisting of 189 males and 126 females were randomly selected. For each adolescent, two specimens were collected for culturing and examination by polymerase chain reaction (PCR). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231717PMC
February 2020

Author Correction: Challenges in the serological evaluation of dogs clinically suspect for canine leishmaniasis.

Sci Rep 2020 May 28;10(1):8988. Epub 2020 May 28.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, R. Alfredo Allen, 4200-135, Porto, Portugal.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41598-020-66088-5DOI Listing

LEISHMANICIDAL ACTIVITY in vivo OF A MILTEFOSINE DERIVATIVE IN Mesocricetus auratus.

Acta Trop 2020 May 24;209:105539. Epub 2020 May 24.

Department of Pathology and Parasitology, Institute of Biomedical Science, Universidade Federal de Alfenas, Minas Gerais state, Brazil. Electronic address:

Visceral leishmaniasis (VL) is a chronic and systemic disease; if untreated, it can cause death in a large number of cases. The therapy is based on the use of antimonials, which have been used for over 50 years. However, cases of resistance have been reported in some countries. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105539DOI Listing

B cell profile, B-cell activating factor concentration and IgG levels in human cutaneous and mucosal leishmaniasis.

Parasite Immunol 2020 May 27:e12759. Epub 2020 May 27.

Laboratorio de Inmunología, Instituto de Medicina Experimental-CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina.

Aims: The aim of this study was to evaluate characteristics of B cells in human tegumentary leismaniasis (TL) analyzing cutaneous leishmaniasis (CL), most prevalent form and mucosal leishmaniasis (ML), aggressive form characterized by the destruction of the oral-nasal-pharyngeal cavities.

Methods And Results: By flow cytometry analysis we found decreased percentages of nonclass-switched memory B cells in TL with the degree of the loss related to clinical severity. Using commercial ELISA, we reported high levels of B-cell activating factor (BAFF) and IgG preferentially in aggressive CL and markedly in ML together with decreased BAFF receptors in the latter. Read More

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http://dx.doi.org/10.1111/pim.12759DOI Listing

Membranoproliferative Glomerulonephritis and Mixed Cryoglobulinemia as a Form of Presentation of Visceral Leishmaniasis.

Am J Case Rep 2020 May 27;21:e921445. Epub 2020 May 27.

Department of Nephrology, Virgin Health Hospital, Toledo, Spain.

BACKGROUND Visceral leishmaniasis (VL) is an endemic systemic disease in the Mediterranean countries, including Spain. This vector-borne infection can present with several clinical presentations, from asymptomatic to severe forms. Renal impairment is frequently described in VL but is usually mild and related to interstitial nephritis, being that glomerular involvement is rarely found. Read More

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http://dx.doi.org/10.12659/AJCR.921445DOI Listing

High Performance of ELISA test using recombinant rLiNTPDase2 from Leishmania infantum: a Phase II diagnosis of Canine Visceral Leishmaniasis.

Acta Trop 2020 May 22:105535. Epub 2020 May 22.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Av. P. H. Rolfs, s/n, Campus Universitário, CEP: 36570-000 Viçosa, MG, Brazil.

Canine visceral leishmaniasis (CVL) has been the theme of several studies given the importance of dog as natural reservoir of the pathogen Leishmania infantum in endemic regions and its role on dissemination of CVL and human visceral Lesihmaniasis (VL). The current immunodiagnosis of CVL has limitations concerning accuracy, specificity and sensitivity. Therefore, improvements are required. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105535DOI Listing

Molecular identification of Leishmania in free-ranging black and gold howler monkeys (Alouatta caraya) in northeastern Argentina.

Acta Trop 2020 May 22:105534. Epub 2020 May 22.

Instituto Nacional de Medicina Tropical (INMeT), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS), Ministerio de Salud de la Nación. Almafuerte y Ámbar, CP 3370, Puerto Iguazú, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Godoy Cruz 2290, CABA, Argentina.

Parasitological surveys of non-human primates provides an important opportunity to better understand the epidemiology, transmission dynamics and emergence risk of anthropozoonoses such as leishmaniasis, which affect human populations in several regions accross South America. Our study area, in northeastern Argentina, can be considered a southern marginal region for the presence of leishmaniases and includes the habitat of black and gold howler monkeys, Alouatta caraya. To evaluate if A. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105534DOI Listing

Leishmania infection in cats positive for immunodeficiency virus and feline leukemia virus in an endemic region of Iran.

Vet Parasitol Reg Stud Reports 2020 Apr 26;20:100387. Epub 2020 Feb 26.

Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.

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http://dx.doi.org/10.1016/j.vprsr.2020.100387DOI Listing

A Systematic Literature Review of Curcumin With Promising Antileishmanial Activity.

Infect Disord Drug Targets 2020 May 24. Epub 2020 May 24.

Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, P.O Box: 48471-91971, Sari. Iran.

Background: Curcumin (CUR) is a bright yellow chemical and it is used as an additive in foods. Recently CUR and its associated bioactive compounds have received much attention in the literature review. The aim of this systematic review is to overview antileishmanial properties of CUR and its mechanism, perhaps the results of this study will be used for therapeutic and preventive purposes. Read More

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http://dx.doi.org/10.2174/1871526520666200525013458DOI Listing