26,434 results match your criteria Leishmaniasis


Cutaneous leishmaniasis in Qasr-e Shirin, a border area in the west of Iran.

Vet World 2018 Dec 17;11(12):1692-1697. Epub 2018 Dec 17.

Department of Medical Parasitology and Mycology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Aim: The prevalence of cutaneous leishmaniasis (CL) is growing in Iran, and new sources of the disease have been found in the country. The purpose of this study was to describe the epidemiology of CL in Qasr-e Shirin County, Kermanshah Province, West of Iran. Qasr-e Shirin is located near the Iran-Iraq border, and several million pilgrims pass through this area to Iraq every year. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1692-1697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362329PMC
December 2018

Rhinophyma-Like Cutaneous Leishmaniasis due to Treated Successfully with Liposomal Amphotericin B.

Am J Trop Med Hyg 2019 Feb;100(2):231-232

Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.4269/ajtmh.18-0578DOI Listing
February 2019

Cloning, expression and purification of 3'-nucleotidase/nuclease, an enzyme responsible for the Leishmania escape from neutrophil extracellular traps.

Mol Biochem Parasitol 2019 Feb 14. Epub 2019 Feb 14.

Instituto de Bioquímica Médica Leopoldo de Meis (IBqM), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address:

Leishmaniasis is one of the most significant of the neglected tropical diseases, with 350 million people in 98 countries worldwide living at risk of developing one of the many forms of the disease. During the transmission of the parasite from its vector to the vertebrate host, neutrophils are rapidly recruited to the site of the sandfly bite. Using different strategies, neutrophils can often kill a large number of parasites. Read More

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http://dx.doi.org/10.1016/j.molbiopara.2019.02.004DOI Listing
February 2019

Detection of mixed Leishmania infections in dogs from an endemic area in southeastern Brazil.

Acta Trop 2019 Feb 14. Epub 2019 Feb 14.

Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Brazil. Electronic address:

In Brazil, the visceral leishmaniasis (VL) is caused by Leishmania infantum, while the tegumentary leishmaniasis (TL) etiological agents are mainly Leishmania braziliensis and Leishmania amazonensis. The canine visceral leishmaniasis (CVL) diagnosis is an important step of the VL control program in Brazil, which involves the elimination of infected dogs, the main urban VL reservoirs. The current serology-based diagnostic tests have shown cross-reactivity between these three species, whereas molecular diagnosis allows high sensitivity and specie identification. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.016DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019

Focal spleen lesions in visceral leishmaniasis, a neglected manifestation of a neglected disease: report of three cases and systematic review of literature.

Infection 2019 Feb 15. Epub 2019 Feb 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Background: The Mediterranean area is endemic for the zoonotic form of visceral leishmaniasis (VL) caused by Leishmania infantum, a species which has been recently associated with unexpected epidemiological and clinical features.

Method: We report the result of a systematic review of the literature on VL unusually presenting with spleen focal lesions, including three previously unpublished cases.

Results: A total of 28 cases of VL with multiple spleen focal lesions were retrieved. Read More

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http://dx.doi.org/10.1007/s15010-019-01279-5DOI Listing
February 2019

The role of sloths and anteaters as Leishmania spp. reservoirs: a review and a newly described natural infection of Leishmania mexicana in the northern anteater.

Parasitol Res 2019 Feb 15. Epub 2019 Feb 15.

Departamento de Producción Agrícola y Animal, Universidad Autónoma Metropolitana, Calzada del Hueso 1100, Col. Villa Quietud, Del. Coyoacán, C.P. 04960, Mexico City, Mexico.

For years, mammals of the order Pilosa have been considered Leishmania reservoirs. But while most studies have focused on sloth species, anteaters have been overlooked, and in many Leishmania endemic countries like Mexico, no studies have been carried out. The aims of this work were to identify the presence of Leishmania spp. Read More

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http://dx.doi.org/10.1007/s00436-019-06253-6DOI Listing
February 2019
2.327 Impact Factor

Nanostructured cochleates: A multi-layered platform for cellular transportation of therapeutics.

Drug Dev Ind Pharm 2019 Feb 15:1-37. Epub 2019 Feb 15.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM's NMIMS , V. L. Mehta Road , Vile Parle (W), Mumbai , India.

Among lipid-based nanocarriers, multi-layered cochleates emerge as a novel delivery system because of prevention of oxidation of hydrophobic and hydrophilic drugs, enhancement in permeability and reduction in dose of drugs. It also improves oral bioavailability and increases the safety of a drug by targeting at a specific site with less side effects. Nanostructured cochleates are used as a carrier for the delivery of water-insoluble or hydrophobic drugs of anti-cancer, antiviral and anti-inflammatory action. Read More

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http://dx.doi.org/10.1080/03639045.2019.1583757DOI Listing
February 2019

Visceral leishmaniasis with haemophagocytic lymphohistiocytosis.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of General Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

A 27-year-old man presented with high-grade intermittent fever for 4 months, generalised fatigue for 2 months, intermittent gum bleeds for 1 month and loss of weight of 15 kg. He appeared cachectic with generalised wasting, had pallor and features of reticuloendothelial system proliferation. His liver span was 17 cm. Read More

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http://dx.doi.org/10.1136/bcr-2018-226361DOI Listing
February 2019

[Sandflies Fauna of the Focus of Keur Moussa: Current Data on Diversity and Seasonal Variations (Thies, Senegal)].

Bull Soc Pathol Exot 2018 ;111(1):38-45

Laboratoire de zoologie des invertébrés terrestres, Institut fondamental d'Afrique noire Cheikh-Anta-Diop, université Cheikh-Anta-Diop, B.P. 206, Dakar, Sénégal.

An inter-epidemic oversight was conducted in the cutaneous leishmaniasis focus of Keur Moussa (Thies region) between June 2015 and October 2016, more than 20 years after the last epidemic. The three sampling methods (adhesive traps, CDC light traps, and indoor pyrethroids sprays) allowed the capture of 1,746 sand flies belonging to 2 genera and 24 species, those involved in the transmission of leishmaniasis in Senegal, as well as 11 new species for the focus. The vector of human cutaneous leishmaniasis in Senegal, Neveu-Lemaire, 1906, represents 10. Read More

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http://dx.doi.org/10.3166/bspe-2018-0012DOI Listing
January 2018

A chronic bioluminescent model of experimental visceral leishmaniasis for accelerating drug discovery.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007133. Epub 2019 Feb 14.

Departamento de Ciencias Biomédicas, Universidad de León, León, Spain.

Background: Visceral leishmaniasis is a neglected parasitic disease with no vaccine available and its pharmacological treatment is reduced to a limited number of unsafe drugs. The scarce readiness of new antileishmanial drugs is even more alarming when relapses appear or the occurrence of hard-to-treat resistant strains is detected. In addition, there is a gap between the initial and late stages of drug development, which greatly delays the selection of leads for subsequent studies. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007133DOI Listing
February 2019

Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic -infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0982DOI Listing
February 2019

Cloning and molecular characterization of thiol-specific antioxidant gene of Leishmania tropica Turkey isolate

Turk J Med Sci 2019 Feb 11;49(1):392-402. Epub 2019 Feb 11.

Background/aim: Thiol-specific antioxidant (TSA) protein is one of the most promising molecules among candidates for vaccine against cutaneous leishmaniasis. It was found to be significantly protective against different Leishmania species. In this study, cloning and molecular characterization of thiol-specific antioxidant gene of L. Read More

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http://dx.doi.org/10.3906/sag-1808-98DOI Listing
February 2019

Maternal Leishmania infantum infection status has significant impact on leishmaniasis in offspring.

PLoS Negl Trop Dis 2019 Feb 13;13(2):e0007058. Epub 2019 Feb 13.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United States of America.

Visceral Leishmaniasis is a deadly disease caused by Leishmania infantum, endemic in more than 98 countries across the globe. Although the most common means of transmission is via a sand fly vector, there is growing evidence that vertical transmission may be critical for maintaining L. infantum infection within the reservoir, canine, population. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007058DOI Listing
February 2019

Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Species.

J Immunol Res 2019 10;2019:4103819. Epub 2019 Jan 10.

Department of Biology, University of Northern Iowa, Cedar Falls, IA 50614, USA.

Worldwide, an estimated 12 million people are infected with spp. and an additional 350 million are at risk of infection. Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses. Read More

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http://dx.doi.org/10.1155/2019/4103819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348913PMC
January 2019

Fever of Unknown Origin: Don't Forget Kala-Azar Even in Europe.

Eur J Case Rep Intern Med 2018 22;5(2):000772. Epub 2018 Feb 22.

Haematology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.

We present the case of a 70-year-old male patient with fever of unknown origin after a long period of convalescence from a previous admission to a chronic care hospital. During the admission, multiple combinations of antibiotic and antifungal treatments were prescribed, but with persistent fever and, eventually, neutropenia (200 lymphocytes, 0 neutrophils). Given the suspicion of infection at bone marrow level, a biopsy was performed as was serology of , both diagnostic determinations. Read More

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http://dx.doi.org/10.12890/2017_000772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346938PMC
February 2018

Re-Emerging foci of visceral leishmaniasis in Armenia - first molecular diagnosis of clinical samples.

Parasitology 2019 Feb 13:1-8. Epub 2019 Feb 13.

Division Molecular Biotechnology and Functional Genomics,Technical University of Applied Sciences Wildau,Hochschulring 1, 15745 Wildau,Germany.

Visceral leishmaniasis (VL) was firstly reported in Armenia in 1913. Following a considerable increase of the number of cases until the mid 1950s, the disease disappeared after 1969 and re-emerged in 1999. Scientific literature about VL in Armenia is available only in Russian or Armenian. Read More

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http://dx.doi.org/10.1017/S0031182019000064DOI Listing
February 2019

Modeling the Ecological Niche: A Case Study on Bioclimatic Factors Related to the Distribution of Phlebotomus tobbi Adler & Theodor (Diptera: Psychodidae) in Two Endemic Foci of Adana.

Authors:
Hakan Kavur

J Med Entomol 2019 Feb 12. Epub 2019 Feb 12.

Cukurova University, Karaisali Vocational School, Adana, Turkey.

Cutaneous leishmaniasis (CL) is a zoonotic infectious disease caused mainly by Leishmania infantum Nicolle, 1908 (Kinetoplastida: Trypanosomatida) transmitted by dominant species Phlebotomus tobbi Adler & Theodor (Diptera: Psychodidae) in Adana, Turkey. CL has been reported to be detected commonly in low-socioeconomic status population scattered in rural areas. The environmental determinants are relatively poorly understood, especially in Adana despite the fact that Adana is endemic foci of CL. Read More

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http://dx.doi.org/10.1093/jme/tjz008DOI Listing
February 2019

Residual Efficacy of Insecticides Sprayed on Different Types of Surfaces Against Leishmaniasis and Filariasis Vectors in Egypt.

J Med Entomol 2019 Feb 9. Epub 2019 Feb 9.

Entomology Branch, Walter Reed Army Institute of Research, Silver Spring, Silver Spring, MD.

Determination of the residual activity of insecticides is an essential component in the selection of an appropriate insecticide for indoor residual spraying operations. This report presents the results of a laboratory study to evaluate the residual bio-efficacy of four insecticides sprayed on the most common house-wall surfaces that occur in Egypt (wood, mud, and cement) against Phlebotomus papatasi (Scopoli, 1786) (Diptera: Psychodidae) and Culex pipiens Linnaeus, 1758 (Diptera: Culicidae). In total, 28,050 P. Read More

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http://dx.doi.org/10.1093/jme/tjy243DOI Listing
February 2019

Discovery of new organoselenium compounds as antileishmanial agents.

Bioorg Chem 2019 Jan 31;86:339-345. Epub 2019 Jan 31.

Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address:

We report new organoselenium compounds bearing the sulfonamide moiety as effective inhibitors of the β-isoform of Carbonic Anhydrase from the unicellular parasitic protozoan L. donovani chagasi. All derivatives were evaluated in vitro for their leishmanicidal activities against Leishmania infantum amastigotes along with their cytotoxicities in human THP-1 cells. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.069DOI Listing
January 2019
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The safety and efficacy of miltefosine in the long-term treatment of post-kala-azar dermal leishmaniasis in South Asia - A review and meta-analysis.

PLoS Negl Trop Dis 2019 Feb 11;13(2):e0007173. Epub 2019 Feb 11.

Public Health Department, Médecins Sans Frontières, Amsterdam, The Netherlands.

Background: Miltefosine (MF) is the only oral drug available for treatment of visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). Although the drug is effective and well tolerated in treatment of VL, the efficacy and safety of MF for longer treatment durations (>28 days) in PKDL remains unclear. This study provides an overview of the current knowledge about safety and efficacy of long treatment courses with MF in PKDL, as a strategy in the VL elimination in South Asia. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007173DOI Listing
February 2019

Intestinal Nematode Infection Exacerbates Experimental Visceral Leishmaniasis.

Parasite Immunol 2019 Feb 11:e12618. Epub 2019 Feb 11.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.

Leishmania donovani exposure often results in subclinical infection in immunocompetent individuals, and the factors dictating development of visceral leishmaniasis (VL) are not known. Infection with intestinal worms skew immunity towards type 2 and regulatory responses, thereby theoretically increases susceptibility to intracellular infections controlled by type 1 responses. Here we tested how chronic infection with the intestinal nematode Heligmosomoides polygyrus affected immunity to a secondary infection with L. Read More

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http://dx.doi.org/10.1111/pim.12618DOI Listing
February 2019

Host competence of African rodents and for .

Int J Parasitol Parasites Wildl 2019 Apr 24;8:118-126. Epub 2019 Jan 24.

Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.

Cutaneous leishmaniasis caused by is a typical zoonosis circulating in rodents. In Sub-Saharan Africa the reservoirs remain to be identified, although has been detected in several rodent species including members of the genera and . However, differentiation of true reservoir hosts from incidental hosts requires in-depth studies both in the field and in the laboratory, with the best method for testing the infectiousness of hosts to biting vectors being xenodiagnosis. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356118PMC

Anorectal tumor as a debut form of visceral leishmaniasis.

Surgery 2018 Dec 17;164(6):1390-1391. Epub 2018 Sep 17.

Hospital Universitario Reina Sofía, Córdoba, Spain.

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http://dx.doi.org/10.1016/j.surg.2018.08.010DOI Listing
December 2018

Protection induced by Leishmania Major antigens and the imiquimod adjuvant encapsulated on liposomes in experimental cutaneous leishmaniasis.

Infect Genet Evol 2019 Feb 6. Epub 2019 Feb 6.

Immunogenetics Research Center, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

There is a need for new, effective, and less expensive and toxic treatment for Leishmaniasis. It seems that the use of a suitable adjuvant and a delivery system is effective in inducing immune reactions for protection. Liposomes can be applied as immunoadjuvants to trigger immune reactions to different antigens. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.01.005DOI Listing
February 2019
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Use of miltefosine to treat canine visceral leishmaniasis caused by Leishmania infantum in Brazil.

Parasit Vectors 2019 Feb 8;12(1):79. Epub 2019 Feb 8.

Ingrid Menz Self-employed Veterinarian, São Paulo, Campinas, Brazil.

Background: Visceral leishmaniasis (VL) is an infectious disease with a variety of clinical signs. The main form of parasite transmission to humans and other mammalian hosts is through the bite of infected arthropod females with Lutzomyia longipalpis serving as the main vector in the Americas. Dogs are the main urban domestic reservoirs of the parasite and the main source of vector infection due to their high prevalence in endemic areas and the large number of parasites in the skin of infected animals. Read More

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http://dx.doi.org/10.1186/s13071-019-3323-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368741PMC
February 2019

Osteopontin in the host response to Leishmania amazonensis.

BMC Microbiol 2019 Feb 8;19(1):32. Epub 2019 Feb 8.

Immunophysiology and Parasitism Laboratory and Department of Parasites and Insect Vectors, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, France.

Background: Leishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). In C57BL/6 mice virulence with L. Read More

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http://dx.doi.org/10.1186/s12866-019-1404-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368773PMC
February 2019

Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors.

J Enzyme Inhib Med Chem 2019 Dec;34(1):333-342

a Programa de pós-graduação em Biotecnologia , Universidade Estadual de Feira de Santana , Feira de Santana , BA , Brazil.

Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geographic distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, is the most prevalent species in Brazil. Superoxide dismutase (SOD) belongs to the antioxidant pathway of the parasites and human host. Read More

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http://dx.doi.org/10.1080/14756366.2018.1550752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327998PMC
December 2019

Investigation of Safety Profile of Four Species and of Kaurenoic Acid by /Microsome Test.

Evid Based Complement Alternat Med 2019 10;2019:7631531. Epub 2019 Jan 10.

Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil.

Trees of the genus are native to the tropical regions of Latin America and Western Africa. sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Read More

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http://dx.doi.org/10.1155/2019/7631531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348810PMC
January 2019
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In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion.

BMC Genomics 2019 Feb 7;20(1):118. Epub 2019 Feb 7.

Instituto Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz-Pernambuco), Recife, Pernambuco, Brazil.

Background: The leishmaniasis are parasitic diseases caused by protozoans of the genus Leishmania, highly divergent eukaryotes, characterized by unique biological features. To survive in both the mammalian hosts and insect vectors, these pathogens make use of a number of mechanisms, many of which are associated with parasite specific proteases. The metalloprotease GP63, the major Leishmania surface antigen, has been found to have multiple functions required for the parasite's survival. Read More

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http://dx.doi.org/10.1186/s12864-019-5465-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367770PMC
February 2019

Intralesional sodium stibogluconate under inhaled anesthesia for the treatment of cutaneous leishmaniasis in children: A retrospective cohort.

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.01.083DOI Listing
February 2019
4.449 Impact Factor

Socioenvironmental aspects of the Purus Region - Brazilian Amazon: Why relate them to the occurrence of American Tegumentary Leishmaniasis?

PLoS One 2019 7;14(2):e0211785. Epub 2019 Feb 7.

Instituto Leônidas e Maria Deane/Fundação Oswaldo Cruz Manaus-ILMD/FIOCRUZ,-Manaus-AM, Brazil.

This study aims to analyze factors related to the occurrence of American Tegumentary Leishmaniasis in the Purus Region, based on the reporting of cases between 2001 and 2013, correlating them with livelihoods and subsistence farming in the region, and analyzing them in regards to sex, age, clinical form, occupation, diagnostic methods and seasonality. The analysis parameter which was used included all cases of American Tegumentary Leishmaniasis in each sub-region by municipality. The Purus Region, between the states of Amazonas and Acre, consists of three sub-regions: Upper, Middle, and Lower Purus. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211785PLOS
February 2019
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Detection, genotyping, and phylogenetic analysis of Leishmania isolates collected from infected Jordanian residents and Syrian refugees who suffered from cutaneous leishmaniasis.

Parasitol Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Land Management and Environment, Faculty of Natural Resources and Environment, Hashemite University, Zarqa, 13115, Jordan.

Leishmania is a parasitic protozoan which is transmitted to humans through the bite of an infected female Phlebotomus and Lutzomyia sand flies. Cutaneous leishmaniasis (CL), caused by Leishmania major and L. tropica, is an endemic disease in many areas of Jordan and considered as a major public health problem. Read More

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http://dx.doi.org/10.1007/s00436-019-06222-zDOI Listing
February 2019

Entomological inventory of Phlebotomine sand flies and epidemiological study of leishmaniasis in Afourer, Azilal province, High Atlas, Morocco.

Med Sante Trop 2019 Feb 7. Epub 2019 Feb 7.

Laboratoire de biotechnologie, environnement et qualité, Département de biologie, Faculté des sciences, Université Ibn Tofaïl, Kénitra, Maroc.

In Morocco, leishmaniases are a major public health problem due to their genetic diversity and geographical distribution. Cutaneous leishmaniasis caused by L. tropica is endemic in the center of the country; it has a high risk of transmission, with Phlebotomus sergenti as vector. Read More

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http://dx.doi.org/10.1684/mst.2018.0840DOI Listing
February 2019

Visceral leishmaniasis in a patient with lung tumour: a case report.

Trop Doct 2019 Feb 6:49475519825781. Epub 2019 Feb 6.

Professor, Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio," Chieti, Pescara, Italy.

An increasing use of immunosuppressant medication mandates clinicians to look for leishmaniasis even in non-HIV febrile patients. We report this case to highlight leishmaniasis as a cause of fever in patients undergoing chemotherapy in an endemic area. Read More

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http://dx.doi.org/10.1177/0049475519825781DOI Listing
February 2019

Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects.

An Bras Dermatol 2019 Jan-Feb;94(1):9-16

Immunology Service, Hospital Universitário Prof. Edgar Santos, Universidade Federal da Bahia, Salvador (BA), Brazil.

Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is observed in almost half of cases. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360961PMC
September 2018

Evaluation of three recombinant proteins for the development of ELISA and immunochromatographic tests for visceral leishmaniasis serodiagnosis.

Mem Inst Oswaldo Cruz 2019 Feb 4;114:e180405. Epub 2019 Feb 4.

Universidade Federal de Minas Gerais, Faculdade de Farmácia, Belo Horizonte, MG, Brasil.

Background: Visceral Leishmaniasis (VL) is an infectious disease that is a significant cause of death among infants aged under 1 year and the elderly in Brazil. Serodiagnosis is a mainstay of VL elimination programs; however, it has significant limitations due to low accuracy.

Objective: This study aimed to evaluate three recombinant Leishmania infantum proteins (rFc, rC9, and rA2) selected from previous proteomics and genomics analyses to develop enzyme-linked immunosorbent assay (ELISA) and immunochromatographic tests (ICT) for the serodiagnosis of human VL (HVL) and canine VL (CVL). Read More

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http://dx.doi.org/10.1590/0074-02760180405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364332PMC
February 2019
1 Read

Improving the reference standard for the diagnosis of canine visceral leishmaniasis: a challenge for current and future tests.

Mem Inst Oswaldo Cruz 2019 Jan 31;114:e180452. Epub 2019 Jan 31.

Universidade de Brasília, Núcleo de Medicina Tropical, Brasília, DF, Brasil.

Background: Studies aimed at validating canine visceral leishmaniasis diagnostic tests present heterogeneous results regarding test accuracy, partly due to divergences in reference standards used and different infection evolution periods in animals.

Objective: This study aimed to evaluate the accuracy of the rapid test-dual path platform (TR-DPP) (Biomanguinhos®), EIE-Leishmaniose-Visceral-Canina-Biomanguinhos (EIE-LVC) (Biomanguinhos®), enzyme-linked immunosorbent assay (ELISA) rK39 (in-house), and the direct agglutination test (DAT-Canis) against a reference standard comprising parasitological and molecular techniques.

Methods: A phase II/III validation study was carried out in sample sera from 123 predominantly asymptomatic dogs living in an area endemic for visceral leishmaniasis. Read More

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http://dx.doi.org/10.1590/0074-02760180452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358009PMC
January 2019

[Liposomal amphotericin B treatment of cutaneous leishmaniasis caused by L. braziliensis: an imported case report].

Rev Chilena Infectol 2018 ;35(5):612-616

Departamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Leishmaniasis is an infection caused by protozoa of the genus Leishmania sp. and transmitted by sandfly vectors. Cutaneous leishmaniasis (CL) is the most frequent form of presentation. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500612DOI Listing
January 2018

Isolated conjunctival involvement in a case of cutaneous leishmaniasis.

Trop Doct 2019 Feb 5:49475519827112. Epub 2019 Feb 5.

4 Professor, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1177/0049475519827112DOI Listing
February 2019

[Parasitic diseases].

MMW Fortschr Med 2019 Feb;161(2):51-57

beide Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

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http://dx.doi.org/10.1007/s15006-019-0002-1DOI Listing
February 2019
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Detection of multiple circulating Leishmania species in Lutzomyia longipalpis in the city of Governador Valadares, southeastern Brazil.

PLoS One 2019 5;14(2):e0211831. Epub 2019 Feb 5.

Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Leishmaniasis encompasses a group of diverse clinical diseases caused by protozoan parasites of the Leishmania genus. This disease is a major public health problem in the New World affecting people exposed in endemic regions. The city of Governador Valadares (Minas Gerais/Brazil) is a re-emerging area for visceral leishmaniasis, with 191 human cases reported from 2008 to 2017 and a lethality rate of 14. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211831PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363391PMC
February 2019
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Modulation of the immune response and infection pattern to Leishmania donovani in visceral leishmaniasis due to arsenic exposure: An in vitro study.

PLoS One 2019 5;14(2):e0210737. Epub 2019 Feb 5.

Division of Microbiology, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India.

The arsenic contamination of ground water in visceral leishmaniasis (VL) endemic areas in Bihar, India leads to human exposure through drinking water. Possibly, the consumed arsenic (As) accumulates in the tissues of VL patients, who subsequently internalize intracellular amastigotes to confer resistance against chemotherapy to the parasite, leading to modulation in the host's immune response. This hypothesis appears to be consistent with the in vitro findings that in arsenic-exposed parasites, the mitochondrial membrane potential became depolarized, whereas the reduced thiol and lactate production was overexpressed with enhanced glucose consumption; therefore, the reduced thiol possibly supports an immunosuppressive state in the host cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363178PMC
February 2019
2 Reads

Glucose-6-phosphate dehydrogenase (G6PD) activity can modulate macrophage response to Leishmania major infection.

Int Immunopharmacol 2019 Feb 1;69:178-183. Epub 2019 Feb 1.

Department of Clinical Biochemistry, Faculty of Medical Sciences Tarbiat Modares University, Tehran, Iran.

Glucose-6-phosphate dehydrogenase (G6PDH) ultimately plays a critical role in macrophage functions used against infectious agents. The present study investigated whether changes in G6PDH activity could influence the resistance of infected macrophages against Leishmania major infection. Mouse peritoneal and J774 macrophages were infected, respectively, ex vivo and in vitro, with L. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183106
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http://dx.doi.org/10.1016/j.intimp.2019.01.028DOI Listing
February 2019
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Exosome secretion by Leishmania infantum modulate the chemotactic behavior and cytokinic expression creating an environment permissive for early infection.

Exp Parasitol 2019 Feb 1;198:39-45. Epub 2019 Feb 1.

National Reference Center for Leishmaniasis (C.Re.Na.L.), Istituto Zooprofilattico Sperimentale della Sicilia, Via Gino Marinuzzi 3, 90129, Palermo, Italy. Electronic address:

In recent years, several studies demonstrated the role of exosomes in intercellular communications, several Leishmania species belonging to subgenera Leishmania and Viannia have been demonstrated to release exosomes, and their role in parasite-macrophage interactions and in leishmaniasis development has been investigated. However, the release of exosomes by Leishmania infantum has not been studied so far. The aim of this study was to isolate and characterize L. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.01.014DOI Listing
February 2019

Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites.

PLoS Negl Trop Dis 2019 Feb 4;13(2):e0007052. Epub 2019 Feb 4.

Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.

Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis, the potential for emergent resistance to this drug is a considerable threat. Here we characterised four novel amphotericin B-resistant Leishmania mexicana lines. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007052DOI Listing
February 2019

Antimicrobial activity of an antimicrobial peptide against amastigote forms of .

Vet Res Forum 2018 15;9(4):323-328. Epub 2018 Dec 15.

Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Zoonotic cutaneous leishmaniasis caused by is a most common type of vector-borne disease in Iran. The pentavalent antimonial drugs have been used in the treatment of cutaneous leishmaniasis for a long time, but drug resistance and some of serious side effects have been reported. Thus, discovery and development of new therapeutic candidates are needed. Read More

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http://dx.doi.org/10.30466/vrf.2018.33107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346494PMC
December 2018

Visceral Leishmaniasis: Recent Advances in Diagnostics and Treatment Regimens.

Infect Dis Clin North Am 2019 Mar;33(1):79-99

Department of Internal Medicine, University of Gondar, Post Office Box 196, Gondar, Ethiopia.

Diagnostic advances in visceral leishmaniasis include the development of the rK39 and rK28 rapid diagnostic test. The direct agglutination test is also increasingly used, as well as conventional and real-time polymerase chain reaction, which also performs well on peripheral blood. The choice of treatment for visceral leishmaniasis depends on the geographic region where the infection is acquired. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915520183009
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http://dx.doi.org/10.1016/j.idc.2018.10.005DOI Listing
March 2019
6 Reads