26,198 results match your criteria Leishmaniasis


Update on therapy and prevention of canine leishmaniasis.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):315-322. Epub 2018 Dec 12.

Canine leishmaniasis is an emerging infection with increasing importance because the main vector also exists in Germany and autochthonous infections have been described. In this article we present the latest information available regarding therapy and prevention of this disease. Allopurinol-resistant strains were isolated from dogs which experienced recurrent disease while being treated with allopurinol, highlighting the need for alternative treatment options. Read More

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October 2018

Detection of IgG1 against rK39 improves monitoring of treatment outcome in visceral leishmaniasis.

Clin Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Medicine, University of Khartoum, Sudan.

Background: Visceral leishmaniasis (VL), caused by the Leishmania donovani complex, is a fatal neglected tropical disease that is targeted for elimination in India, Nepal and Bangladesh. Improved diagnostic tests are required for early case detection and for monitoring outcome of treatment. Previous investigations using Leishmania lysate antigen demonstrated that IgG1 response is a potential indicator of clinical status after chemotherapy. Read More

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December 2018

Complete and de novo assembly of the Leishmania braziliensis (M2904) genome.

Mem Inst Oswaldo Cruz 2018 Dec 10;114:e180438. Epub 2018 Dec 10.

Universidad Autónoma de Madrid, Centro de Biología Molecular Severo Ochoa, Madrid, Spain.

Leishmania braziliensis is the etiological agent of American mucosal leishmaniasis, one of the most severe clinical forms of leishmaniasis. Here, we report the assembly of the L. braziliensis (M2904) genome into 35 continuous chromosomes. Read More

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December 2018

Molecular typing reveals the co-existence of two transmission cycles of American cutaneous leishmaniasis in the Andean Region of Venezuela with Lutzomyia migonei as the vector.

Mem Inst Oswaldo Cruz 2018 Dec 6;113(12):e180323. Epub 2018 Dec 6.

Universidad de Carabobo, Facultad de Ciencias de la Salud, Centro Nacional de Referencia de Flebotomos y otros Vectores, Instituto de Investigaciones Biomédicas Dr Francisco J Triana-Alonso, Maracay, Venezuela.

BACKGROUND The transmission routes for American cutaneous leishmaniasis (ACL) are in flux, so studies examining its transmission in humans, mammalian hosts, and sand fly vectors are urgently needed. OBJECTIVES The aim of this work was understand the epidemiological cycles of Leishmania spp., which causes ACL in the Andean Region of Venezuela, by identifying the Leishmania and the sand fly species involved in human and dog infections. Read More

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December 2018

Zoonotic impact and epidemiological changes of leishmaniasis in Ethiopia.

Open Vet J 2018 16;8(4):432-440. Epub 2018 Nov 16.

Veterinary Public Health, Aksum University Shire Campus, College of Agriculture, Department of Animal Science, Shire, Ethiopia.

Leishmaniasis is one of the growing public health challenges in Ethiopia and estimated over 7,000 and 50,000 new cases of visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) per year, respectively. The aim of the review is to address zoonotic impact and epidemiological changes of leishmaniasis in Ethiopia. VL is caused by and it is endemic in many parts of the country with one third of the country's landmass is highly suitable for VL. Read More

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November 2018

Evaluation of the efficacy of intralesional Glucantime plus niosomal zinc sulphate in comparison with intralesional Glucantime plus cryotherapy in the treatment of acute cutaneous leishmaniasis, a randomized clinical trial.

J Parasit Dis 2018 Dec 13;42(4):616-620. Epub 2018 Oct 13.

1Leishmaniasis Research Center, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.

Current treatment modalities in cutaneous leishmaniasis have low efficacy and high toxicity as well as high rate of resistance to treatment. In this study, for the first time we decided to evaluate efficacy of intralesional Glucantime plus niosomal zinc sulphate in comparison with intralesional Glucantime plus cryotherapy in the treatment of acute cutaneous leishmaniasis. This is a case-control study on 64 patients with cutaneous leishmaniasis in Kerman-Iran. Read More

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December 2018

Spatio-temporal distribution analysis of zoonotic cutaneous leishmaniasis in Qom Province, Iran.

J Parasit Dis 2018 Dec 13;42(4):570-576. Epub 2018 Oct 13.

6Department of Public Health, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.

Geographic information system (GIS) nowadays is one of the most helpful epidemiological tools for identifying the high risk areas of cutaneous leishmaniasis (CL). This study was conducted to determine the spatio-temporal distribution of CL in Qom province during 2009-2017. In a cross-sectional study, for the survey of spatial dispersion of CL in the study region, the incidence rate of disease was calculated in all of 23 villages during 2009-2017. Read More

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December 2018

Bionomics of phlebotomine sand flies species (Diptera: Psychodidae) and their natural infection with and in Fars province, southern Iran.

J Parasit Dis 2018 Dec 22;42(4):511-518. Epub 2018 Aug 22.

5Research Center for Health Sciences, Institute of Health, Department of Medical Entomology and Vector Control, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Phlebotominae sand flies are involved in human diseases, such as leishmaniasis, and cause a considerable number of deaths every year. Besides, some of them have been identified as allergen sources or the potential mechanical vectors related to nosocomial infections. The present study aimed to assess the monthly activity, fauna, and detection of protozoan agents in phlebotomine sand flies using polymerase chain reaction (PCR) in re-emerging zoonotic cutaneous leishmaniasis foci of Shiraz and Kharameh in Fars province, southern Iran during 2016-2017. Read More

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December 2018

Role of IL-21 in host pathogenesis in experimental visceral leishmaniasis.

J Parasit Dis 2018 Dec 22;42(4):500-504. Epub 2018 Aug 22.

2Department of Biotechnology, Gauhati University, Guwahati, Assam India.

Visceral leishmaniasis (VL) is a major global health problem but still remains one of the neglected tropical diseases. Currently available chemotherapeutics are associated with severe toxicity and increased drug resistance. There is a need to explore for novel therapeutic strategies that could modulate host immune responses or work in synergy with chemotherapy of VL. Read More

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December 2018

Alkyl Length Effects on the DNA Transport Properties of Cu (II) and Zn(II) Metallovesicles: An and Study.

J Drug Deliv 2018 11;2018:2851579. Epub 2018 Nov 11.

Department of Chemistry and Biochemistry, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.

Cationic liposomes with DNA-transportation properties have attracted considerable attention for their ability to deliver medicinal oligonucleotides to mammalian cells. Amongst these are metalloliposomes that use transition metal ions to confer the lipid molecules cationic charge and unique advantages such as redox- and ligand-exchange triggered DNA-release properties. In this study, lipophilic copper (II) and zinc (II) complexes of 1-alkyl-1,4,7-triazacyclononane were prepared to investigate their ability to bind and transfect double stranded DNA with mammalian cells in vitro and in vivo. Read More

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November 2018

Leptin Functions in Infectious Diseases.

Front Immunol 2018 26;9:2741. Epub 2018 Nov 26.

Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and peripheral tissues. Leptin is secreted by adipose tissue and encoded by the obese () gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Read More

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November 2018

Draft Whole-Genome Sequence of Leishmania (Viannia) braziliensis Presenting Leishmania RNA Virus 1, from Western Amazon, Brazil.

Microbiol Resour Announc 2018 Sep 6;7(9). Epub 2018 Sep 6.

Laboratório de Epidemiologia Genética, Fundação Oswaldo Cruz, Fiocruz Rondônia, Porto Velho, Brazil.

Leishmania (Viannia) braziliensis is the main etiological agent of tegumentary leishmaniasis in the neotropics. Here, we report a draft genome sequence (31.2 Mb) of an L. Read More

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September 2018

Effectiveness of deltamethrin-impregnated dog collars on the incidence of canine infection by Leishmania infantum: A large scale intervention study in an endemic area in Brazil.

PLoS One 2018 10;13(12):e0208613. Epub 2018 Dec 10.

Laboratório de Imunopatologia, Programa de Pós-Graduação em Ciências Biológicas, Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.

To reduce morbidity and mortality caused by visceral leishmaniasis (VL), the Brazilian Visceral Leishmaniasis Control and Surveillance Program promotes the diagnosis and treatment of cases, vector control, euthanasia of seropositive dogs, and health education. Nevertheless, the effectiveness of these measures is questionable as they lead to little reduction in the transmission of the disease. Thus, the effectiveness of strategies such as insecticide-impregnated collars, spot-on insecticides, and immunization of dogs should be assessed. Read More

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December 2018

Leishmania infection: Misdiagnosis as cancer and tumor-promoting potential.

Acta Trop 2018 Dec 7. Epub 2018 Dec 7.

Université Côte d'Azur, Inserm, C3M, Nice Cedex 3, France. Electronic address:

Given the prevalence of cancer and leishmaniasis worldwide, the presence of these two pathologies in the same tissue sample may be merely fortuitous. The clinical outcome of both diseases is under the control of innate and adaptive immunity, and in both cases these progressive diseases are characterized by an impaired host Th1 response. As a consequence, the Th2 cytokine microenvironment occurring in progressive leishmaniasis may potentially promote tumor cell proliferation and vice versa. Read More

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December 2018
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The antibiotic resistance-free mammalian expression plasmid vector pPAL for development of third generation vaccines.

Plasmid 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Parasitology, Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (Consejo Superior de Investigaciones Científicas). Calle Ramiro de Maeztu, 9, 28040 Madrid, Spain. Electronic address:

DNA vaccines require a vector to replicate genes and express encoding antigens. Antibiotic resistance genes are often used as selection markers, which must not be released to the environment upon final product commercialization. For this reason, generation of antibiotic resistance-free vectors is imperative. Read More

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December 2018

Transcutaneous immunization using SLA or rLACK skews the immune response towards a Th1 profile but fails to protect BALB/c mice against a Leishmania major challenge.

Vaccine 2018 Dec 5. Epub 2018 Dec 5.

Uniformed Services University of the Health Sciences, Department of Medicine, Bethesda, MD, USA.

Leishmaniasis is an expanding health threat worldwide complicated by the absence of an effective vaccine. We investigated transcutaneous immunization (TCI) as a needle-free immunization route which exploits the abundance of antigen presenting cells in the skin to induce both mucosal and systemic immunity. Leishmania (L. Read More

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December 2018

Progressive dysphonia in a man living in an endemic area for Leishmania infantum.

Med Mal Infect 2018 Dec 6. Epub 2018 Dec 6.

Service de parasitologie-mycologie, centre hospitalier universitaire l'Archet, BP 3079, 062002 Nice cedex 3, France; Inserm U 1065, Centre Méditerranéen de médecine moléculaire, faculté de médecine, université Côte d'Azur, BP 3194, 06204 Nice cedex 3, France.

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December 2018

Cutaneous, mucocutaneous and visceral leishmaniasis in Sweden from 1996-2016: a retrospective study of clinical characteristics, treatments and outcomes.

BMC Infect Dis 2018 Dec 7;18(1):632. Epub 2018 Dec 7.

Division of Dermatology and Venerology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Background: Leishmaniasis is a neglected and poorly reported parasitic infection transmitted by sand flies in tropical and subtropical regions. Knowledge about leishmaniasis has become important in non-endemic countries due to increased migration and travel. Few studies of the clinical management of cutaneous, mucocutaneous and visceral leishmaniasis in non-endemic regions have been published to date. Read More

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December 2018

Validation of NAD Synthase Inhibitors for Inhibiting the Cell Viability of Leishmania donovani: In Silico and In Vitro Approach.

J Biomol Struct Dyn 2018 Dec 10:1-35. Epub 2018 Dec 10.

d Department of Biotechnology , National Institute of Pharmaceutical Education and Research (NIPER) , Hajipur , Bihar , India ;

NAD (nicotinamide adenine dinucleotide) synthase catalyses the biochemical synthesis of NAD, from nicotinic acid adenine dinucleotide (NaAD). NAD may be synthesized through the de novo pathways and/or the salvage pathways in cells. However, in Leishmania parasite, the synthesis of NAD solely depends on the salvage pathways. Read More

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December 2018

In silico Leishmania proteome mining applied to identify drug target potential to be used to treat against visceral and tegumentary leishmaniasis.

J Mol Graph Model 2018 Nov 29;87:89-97. Epub 2018 Nov 29.

Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

New therapeutic strategies against leishmaniasis are desirable, since the treatment against disease presents problems, such as the toxicity, high cost and/or parasite resistance. As consequence, new antileishmanial compounds are necessary to be identified, as presenting high activity against Leishmania, but low toxicity in mammalian hosts. In the present study, a Leishmania proteome mining strategy was developed, in order to select new drug targets with low homology to human proteins, but that are considered relevant for the parasite' survival. Read More

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November 2018
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Visceral leishmaniasis: Spatiotemporal heterogeneity and drivers underlying the hotspots in Muzaffarpur, Bihar, India.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006888. Epub 2018 Dec 6.

Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Background: Despite the overall decrease in visceral leishmaniasis (VL) incidence on the Indian subcontinent, there remain spatiotemporal clusters or 'hotspots' of new cases. The characteristics of these hotspots, underlying transmission dynamics, and their importance for shaping control strategies are not yet fully understood and are investigated in this study for a VL endemic area of ~100,000 inhabitants in Bihar, India between 2007-2015.

Methodology/principal Findings: VL incidence (cases/10,000/year) dropped from 12. Read More

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December 2018

2'-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006930. Epub 2018 Dec 6.

Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil.

Background: To overcome the current problems in leishmaniasis chemotherapy, natural products have become an interesting alternative over the past few decades. Flavonoids have been studied as promising family of compounds for leishmaniasis treatment. 2'-Hydroxyflavanone (2HF) is a flavanone, a class of flavonoid that has shown promising results in cancer studies. Read More

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December 2018
2 Reads

Age trends in asymptomatic and symptomatic Leishmania donovani infection in the Indian subcontinent: A review and analysis of data from diagnostic and epidemiological studies.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006803. Epub 2018 Dec 6.

Zeeman Institute, University of Warwick, Coventry, United Kingdom.

Background: Age patterns in asymptomatic and symptomatic infection with Leishmania donovani, the causative agent of visceral leishmaniasis (VL) in the Indian subcontinent (ISC), are currently poorly understood. Age-stratified serology and infection incidence have been used to assess transmission levels of other diseases, which suggests that they may also be of use for monitoring and targeting control programmes to achieve elimination of VL and should be included in VL transmission dynamic models. We therefore analysed available age-stratified data on both disease incidence and prevalence of immune markers with the aim of collating the currently available data, estimating rates of infection, and informing modelling and future data collection. Read More

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December 2018
2 Reads

Case Reports: Late Emergence of Cutaneous Leishmaniasis in an Immunocompromised Patient in a Non-Endemic Setting.

Am J Trop Med Hyg 2018 Dec 3. Epub 2018 Dec 3.

Monash Medical Centre, School of Clinical Sciences, Monash University, Melbourne, Australia.

We report a case of reactivation of cutaneous leishmaniasis caused by in a 40-year-old man from Afghanistan, in the context of immune suppression. His last potential exposure was 7 years before the clinical presentation. To our knowledge, this is the most temporally distant reactivation of cutaneous leishmaniasis reported in a non-endemic country. Read More

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December 2018

6,7-Dehydroroyleanone diterpene derived from Tetradenia riparia essential oil modulates IL-4/IL-12 release by macrophages that are infected with Leishmania amazonensis.

Parasitol Res 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Colombo Avenue, 5790, bloco J90, sala 03, Maringá, Paraná State, 87020-900, Brazil.

The treatment of cutaneous leishmaniasis in associated with several adverse effects and therapeutic failure, resulting in patients' abandonment of treatment. Research on new drugs with leishmanicidal potential from medicinal plants is essential. The anti-Leishmania activity of Tetradenia riparia essential oil (TrEO) and its derivatives, such as the diterpene 6,7-dehydroroyleanone (TrROY), and the immunomodulatory effects of TrEO have been reported. Read More

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December 2018
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Second-generation pterocarpanquinones: synthesis and antileishmanial activity.

J Venom Anim Toxins Incl Trop Dis 2018 29;24:35. Epub 2018 Nov 29.

1Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCUZ, Av. Brasil, 4365, Pavilhao Leonidas Deane, sala 405A, Manguinhos, Rio de Janeiro, RJ 21040-900 Brazil.

Background: Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The identification of antileishmanial drug candidates is essential to fill the drug discovery pipeline for leishmaniasis. In the hit molecule LQB-118 selected, the first generation of pterocarpanquinones was effective and safe against experimental visceral and cutaneous leishmaniasis via oral delivery. Read More

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November 2018
3 Reads

Immunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against .

Front Immunol 2018 16;9:2558. Epub 2018 Nov 16.

Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil.

Metacyclic promastigotes are transmitted by sand flies that inject parasites and saliva into the host's skin. Previous studies have demonstrated that DNA plasmids encoding salivary proteins LJM17 and LJL143, when used to immunize dogs, resulted in a systemic and local Th1 cell-mediated immunity that interfered in parasite survival . Here we evaluated the ability of these same salivary antigens to induce anti- immunity and to confer protection by immunizing dogs using a novel vaccination strategy more suitable for use in the field. Read More

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November 2018
4 Reads

A randomized, blinded, controlled trial to assess sand fly mortality of fluralaner administered orally in dogs.

Parasit Vectors 2018 Dec 5;11(1):627. Epub 2018 Dec 5.

ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.

Background: Leishmania infantum is the parasite responsible for the disease in humans known as zoonotic visceral leishmaniasis (ZVL). Dogs are considered the main domestic reservoir of ZVL and sand flies are the proven vectors. The use of systemic insecticides in dogs has been studied as an alternative strategy to control ZVL in endemic areas. Read More

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December 2018
1 Read

Ascorbate peroxidase overexpression protects Leishmania braziliensis against trivalent antimony effects.

Mem Inst Oswaldo Cruz 2018 Nov 14;113(12):e180377. Epub 2018 Nov 14.

Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Belo Horizonte, MG, Brasil.

Ascorbate peroxidase (APX) is a redox enzyme of the trypanothione pathway that converts hydrogen peroxide (H2O2) into water molecules. In the present study, the APX gene was overexpressed in Leishmania braziliensis to investigate its contribution to the trivalent antimony (SbIII)-resistance phenotype. Western blot results demonstrated that APX-overexpressing parasites had higher APX protein levels in comparison with the wild-type line (LbWTS). Read More

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November 2018

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in .

mSystems 2018 Nov-Dec;3(6). Epub 2018 Nov 20.

Leishmaniasis Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani, causative agent of the fatal visceral leishmaniasis, HSP90 activity is essential for cell proliferation and survival. Even more importantly, its inhibition causes life cycle progression from the insect stage to the pathogenic, mammalian stage. Read More

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November 2018
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Diffuse Cutaneous Leishmaniasis in an Immunocompromised Patient Resembling Histoid Hansen's Disease.

Indian Dermatol Online J 2018 Nov-Dec;9(6):452-454

Department of Dermatology, Venereology and Leprology, RNT Medical College, Udaipur, Rajasthan, India.

Cutaneous leishmaniasis is caused by protozoan parasites of the genus . Atypical presentation and widespread progression of the lesions may be seen in patients with HIV disease and diffuse cutaneous leishmaniasis and HIV co-infection is emerging as a serious new threat. We report a case of diffuse cutaneous leishmaniasis in a HIV- infected patient resembling Histoid Hansen. Read More

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December 2018
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A nanodelivered Vorinostat derivative is a promising oral compound for the treatment of visceral leishmaniasis.

Pharmacol Res 2018 Nov 29;139:375-383. Epub 2018 Nov 29.

Departamento de Parasitología, Universidad de Granada, Campus de Cartuja sn, 18011, Granada, Spain. Electronic address:

There is currently no satisfactory treatment for visceral leishmaniasis; the disease is thus in desperate need of novel drugs. The ideal candidate should be effective, safe, affordable, and administered via the oral route. Histone deacetylases (HDACs) are involved in silencing critical regulatory pathways, including pro-apoptotic programs, and represent potential therapeutic targets for pharmacological interventions. Read More

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November 2018

An in silico approach in identification of drug targets in Leishmania: A subtractive genomic and metabolic simulation analysis.

Parasitol Int 2018 Nov 29;69:59-70. Epub 2018 Nov 29.

Department of Biotechnology, Savitribai Phule Pune University, Pune 411007, India.

Leishmaniasis is one of the major health issue in developing countries. The current therapeutic regimen for this disease is less effective with lot of adverse effects thereby warranting an urgent need to develop not only new and selective drug candidates but also identification of effective drug targets. Here we present subtractive genomics procedure for identification of putative drug targets in Leishmania. Read More

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November 2018

Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones.

Parasit Vectors 2018 Nov 30;11(1):614. Epub 2018 Nov 30.

Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

Background: The sand fly Lutzomyia longipalpis is the main vector of American visceral leishmaniasis, a disease caused by parasites of the genus Leishmania. Adults of this insect feed on blood (females only) or sugar from plant sources, but their digestion of carbohydrates is poorly studied. Beta-glycosides as esculin and amygdalin are plant compounds and release toxic compounds as esculetin and mandelonitrile when hydrolyzed. Read More

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November 2018

Antiprotozoal action of synthetic cinnamic acid analogs.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):849-853

Plataforma de Bioensaios em Malária e Leishmaniose, Fundação Oswaldo Cruz, Porto Velho, RO, Brasil.

Introduction: Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp. Read More

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December 2017
3 Reads

PCR sensitivity of peripheral blood of dogs co-infected with Leishmania spp. and Ehrlichia spp. in endemic area of Brazil.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):843-847

Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal da Grande Dourados , Dourados, MS, Brasil.

Introduction: Peripheral blood of 400 dogs infected with Leishmania and Ehrlichia were analyzed using polymerase chain reaction (PCR), and clinical signs were characterized.

Methods: PCR and parasitological tests were conducted.

Results: PCR was positive for Leishmania in 84. Read More

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January 2018
1 Read

American cutaneous leishmaniasis in a northeast Brazilian city: clinical and epidemiological features.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):837-842

Faculdade de Medicina, Universidade Federal do Cariri, Barbalha, CE, Brasil.

Introduction: This study characterized the clinico-epidemiological profile of American cutaneous leishmaniasis (ACL) cases in Barbalha, Ceará State, Brazil.

Methods: Medical records of 363 patients visiting Federal University of Cariri between 2009 and 2014 were analyzed.

Results: ACL was more prevalent in men with low education level from rural zones. Read More

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December 2017
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Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):769-780

Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Rio de Janeiro, RJ, Brasil.

Introduction: Favorable responses in American tegumentary leishmaniasis (ATL) patients to treatment with 5 mg Sbv/kg/day meglumine antimoniate (MA) has been reported in Rio de Janeiro, but little is known regarding the therapeutic response to low doses in patients from other locations.

Methods: A retrospective review of medical records was conducted to compare the therapeutic response to 5 mg Sbv/kg/day MA treatment among 36 patients who acquired ATL in Brazilian states other than Rio de Janeiro (OS group) and 72 patients from Rio de Janeiro (RJ group).

Results: One course of 5 mg Sbv/kg/day MA cured 72. Read More

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December 2017
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[Evaluation of ketoconazole formulations for topical use in cutaneous leishmaniasis caused by Leishmania (Viannia)].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):476-482

. Centro de Investigaciones en Enfermedades Tropicales (CINTROP), Escuela de Medicina, Departamento de Ciencias Básicas, Universidad Industrial de Santander. Bucaramanga, Colombia.

The effectiveness of various pharmaceutical formulations of ketoconazole was evaluated in experimental models of cutaneous leishmaniasis (LC) in BALB C mice. Topical gel, lipogel, and cream formulations containing permeation enhancers and different concentrations of ketoconazole were prepared. Stability, toxicity and anti-Leishmania activity were determined in vitro. Read More

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March 2018
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Neutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantum.

Rev Bras Parasitol Vet 2018 Oct-Dec;27(4):430-438

Departamento de Biologia e Ciência Animal, Faculdade de Engenharia de Ilha Solteira - FEIS, Universidade Estadual Paulista - UNESP, Ilha Solteira, SP, Brasil.

Visceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophils, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. Read More

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April 2018
2 Reads

Relationship of peripheral blood mononuclear cells miRNA expression and parasitic load in canine visceral leishmaniasis.

PLoS One 2018 5;13(12):e0206876. Epub 2018 Dec 5.

Department of Animal Clinic, Surgery and Reproduction, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil.

Visceral leishmaniasis (VL) in humans is a chronic and often fatal disease if left untreated. Dogs appear to be the main reservoir host for L. infantum infection, however, in many regions other canids such as jackals, foxes, wolves and other mammals, such as hares or black rats, have been implicated as wild reservoirs. Read More

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December 2018
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The LPG1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties.

Sci Rep 2018 Dec 4;8(1):17566. Epub 2018 Dec 4.

Institut de Chimie Organique et Analytique, UMR CNRS 7311, Université d'Orléans, Rue de Chartres, BP6759, Orléans, Cedex 02, France.

Galactofuranosyltransferases are poorly described enzymes despite their crucial role in the virulence and the pathogenicity of numerous microorganisms. These enzymes are considered as potential targets for therapeutic action. In addition to the only well-characterised prokaryotic GlfT2 from Mycobacterium tuberculosis, four putative genes in Leishmania major were previously described as potential galactofuranosyltransferases. Read More

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December 2018

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.

Parasit Vectors 2018 Dec 4;11(1):622. Epub 2018 Dec 4.

Department of Parasitology, Faculty of Science, University of Granada, Granada, Spain.

Background: Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. In this study, we examine the potential functions of two proteins of Leishmania major, PHB1 and PHB2, as well as how they might help protect the protozoan against oxidative stress. Read More

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December 2018

Leishmanicidal Activity of Withanolides from var. .

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), 210360-040 Rio de Janeiro, Brazil.

Leishmaniasis is the generic denomination to the neglected diseases caused by more than 20 species of protozoa belonging to the genus . The toxic and parenteral-delivered pentavalent antimonials remain to be the first-line treatment. However, all the current used drugs have restrictions. Read More

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November 2018

Human antibody reaction against recombinant salivary proteins of Phlebotomus orientalis in Eastern Africa.

PLoS Negl Trop Dis 2018 Dec 4;12(12):e0006981. Epub 2018 Dec 4.

Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.

Background: Phlebotomus orientalis is a vector of Leishmania donovani, the causative agent of life threatening visceral leishmaniasis spread in Eastern Africa. During blood-feeding, sand fly females salivate into the skin of the host. Sand fly saliva contains a large variety of proteins, some of which elicit specific antibody responses in the bitten hosts. Read More

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December 2018
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Composition and Vertical Stratification of Phlebotomine Sand Fly Fauna and the Molecular Detection of Leishmania in Forested Areas in Rondônia State Municipalities, Western Amazon, Brazil.

Vector Borne Zoonotic Dis 2018 Dec 4. Epub 2018 Dec 4.

1 Laboratório de Entomologia, Fundação Oswaldo Cruz - Fiocruz Rondônia, Porto Velho, Rondônia, Brazil .

This study examined sand fly diversity and the natural infection of sand flies by Leishmania in three localities in Rondônia State: Santo Antônio and São Vicente farm, which are anthropized environments, and the Jamari FLONA, which has not been anthropized. Sand flies were collected in canopies and at ground level using CDC light traps and BG-Sentinel CO traps. Female sand flies were grouped into pools that were subjected to DNA extraction and the samples were subjected to PCR to detect and identify Leishmania. Read More

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December 2018
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Understanding the economic impact of leishmaniasis on households in endemic countries: a systematic review.

Expert Rev Anti Infect Ther 2018 Dec 4. Epub 2018 Dec 4.

b Early Detection and Prevention Section , International Agency for Research on Cancer 150 Cours Albert Thomas, 69008 Lyon , France.

Introduction: Leishmaniasis is a poverty-related disease that causes a significant socioeconomic burden to affected households. Visceral leishmaniasis is fatal if untreated, yet illness costs may lead to delays in accessing care. Skin manifestations of leishmaniasis cause a psychological burden and even longer treatment trajectories. Read More

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December 2018
3 Reads

Zoonotic Leishmaniasis, Bosnia and Herzegovina.

Emerg Infect Dis 2019 Feb 17;25(2). Epub 2019 Feb 17.

Leishmania infantum causes potentially life-threatening disease in humans. To determine the extent of the animal reservoir for this pathogen in Bosnia and Herzegovina, we tested dogs and cats. We found that a large proportion of dogs were exposed to or infected with L. Read More

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February 2019