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Int J Surg Pathol 2022 Feb 23;30(1):114-119. Epub 2021 Aug 23.

12898Kyoto Prefectural University of Medicine, Kyoto, Japan.

Mesectodermal leiomyoma of the ciliary body is a rare benign tumor, showing both neurogenic and myogenic characteristics. This tumor typically shows predilection for women of reproductive age. Because it is almost impossible to clinically distinguish this tumor from malignant melanoma, unnecessary eye enucleations have been unfortunately performed. Read More

Can J Ophthalmol 2021 04 10;56(2):124-129. Epub 2020 Sep 10.

New York Eye and Ear Infirmary of Mount Sinai, New York City, NY.

Objective: To perform micro-incision, trans-iridal, aspiration-cutter-assisted biopsy for ciliary body tumours.

Design: Retrospective, nonrandomized, observational, interventional case series.

Methods: Five consecutive patients undergoing ciliary body tumour biopsy were clinically diagnosed using slit-lamp photography, gonioscopy, high-frequency ultrasound imaging, and systemic radiographic staging. Read More

Surv Ophthalmol 2020 Jul - Aug;65(4):421-437. Epub 2020 Jan 7.

The New York Eye and Ear Infirmary, Mount Sinai Hospital, New York, NY, USA.

Intraocular leiomyoma is a benign smooth muscle tumor. First recognized before the era of immunohistochemistry, uveal leiomyomas have been described in case reports and small case series. We add 3 new cases, for a total of 80. Read More

Surv Ophthalmol 2017 May - Jun;62(3):366-370. Epub 2016 Nov 24.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address:

Intraocular leiomyomas are uncommon and usually occur in the ciliary body. Primary leiomyoma of the iris is both rare and a difficult diagnosis to make, given melanocytic tumors are more common and may be amelanotic. The somewhat controversial diagnosis of iris leiomyoma requires further confirmation by immunohistochemistry and electron microscopy. Read More

J Fr Ophtalmol 2015 Feb 13;38(2):e29-32. Epub 2015 Jan 13.

Service d'ophtalmologie, CHU d'Amiens, site Sud, avenue René-Laënnec, 80054 Salouel, Amiens, France.

Eye (Lond) 2013 May 22;27(5):669-72. Epub 2013 Mar 22.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Background/aims: A prospective study identified three patients between 2004 and 2010 with mesectodermal leiomyoma. The study was conducted to analyse the presence or absence of sex steroid hormone receptors in mesectodermal leiomyomas.

Methods: The clinical features were collated. Read More

Acta Clin Croat 2012 Dec;51 Suppl 1:83-6

Department of Ultrasonography, Hospital Luis Sánchez Bulnes Asociación Para Evitar la Ceguera en México IAP, DF México.

A 41-year-old female complained of impaired vision on her left eye in the past year. Her visual acuity was 20/20 on the right eye and 20/50 on the left eye. In her left eye, there was an ill-defined, irregularly pigmented, orange lesion at 7 o'clock meridian behind the iris. Read More

Ophthalmology 2012 Dec 20;119(12):2507-13. Epub 2012 Aug 20.

Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Purpose: To describe the outcome of intraocular tumor resection by partial lamellar sclerouvectomy (PLSU) in the pediatric age group.

Design: Retrospective, interventional case series.

Participants: We included 37 patients who underwent PLSU for intraocular tumors under age 21 years. Read More

Arch Ophthalmol 2011 Dec;129(12):1635-7

J Cataract Refract Surg 2012 Jan;38(1):170-3

Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, Florida, USA.

A 61-year-old African American man presented with decreased vision of 2 months duration. Examination revealed a significant lenticular astigmatism and sectoral cataract as a result of an amelanotic iris lesion. Slitlamp optical coherence tomography (OCT) revealed angle crowding. Read More

Int J Gynecol Cancer 2007 May-Jun;17(3):724-8. Epub 2007 Feb 9.

Department of Gynecology, Shinsuma Hospital, Kobe, Hyogo, Japan.

Uterine leiomyosarcoma, initially diagnosed as leiomyoma on magnetic resonance (MR) images, was disclosed after focused ultrasound surgery (FUS). The tumor did not display high signal intensity on either T1- or T2-weighted images on the patient's first visit. Four months thereafter, T2-weighted images revealed a high signal intensity area within the tumor, while T1-weighted images showed low signal intensity. Read More

Vestn Oftalmol 2006 Nov-Dec;122(6):47

Taiwan J Obstet Gynecol 2006 Jun;45(2):124-8

Department of Obstetrics and Gynecology, Chi Mei Hospital, Liouying, Tainan, Taiwan.

Objective: To investigate the change in volume of uterine fibroids after GnRH analog (GnRHa) treatment.

Materials And Methods: Twenty-five patients who had a uterine leiomyoma were included in this study. Four of them were lost to follow-up during the study, and a myomectomy was performed on the remaining subjects. Read More

Acta Ophthalmol Scand 2004 Feb;82(1):112-4

Vet Ophthalmol 2003 Jun;6(2):173-6

Department of Veterinary Clinical Studies, University of Glasgow, UK.

A leiomyoma of the iris is described in an 11-year-old Yorkshire Terrier. This is a rare primary intraocular tumor in dogs and we describe the clinical presentation, gross findings and histopathologic characteristics of this tumor. The diagnosis was made on the basis of light microscopy and immunohistochemical staining using antidesmin antibodies, which is specific for myogenic tissues. Read More

Surv Ophthalmol 2000 Jan-Feb;44(4):336-42

Medical and Vision Research Foundation, Chennai, India.

Leiomyoma of the ciliary body is a rare tumor that often causes a diagnostic dilemma. Sclerouvectomy has been found to be beneficial in the management of iris and ciliary body leiomyoma. We treated a case of leiomyoma of the ciliary body presenting as a fleshy mass in the anterior chamber, removed by partial lamellar sclerouvectomy. Read More

Ultrastruct Pathol 1997 Nov-Dec;21(6):559-67

Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Unlike smooth muscle elsewhere in the body, the smooth muscle of the iris and ciliary body is derived from neuroectoderm (mesectoderm). Leiomyomas that arise from the ciliary body, and therefore are of mesectodermal origin, may resemble spindle cell neurogenic tumors by light microscopy. They show positive immunostaining for smooth muscle actin but negative staining for neural markers. Read More

Acta Ophthalmol Scand 1997 Aug;75(4):470-3

University Eye Department, The National Hospital, Rikshospitalet, University of Oslo, Norway.

Purpose: To report an iris leiomyoma documented in accordance with today's stricter diagnostic criteria.

Methods: Light microscopy, immunohistochemistry and electron microscopy were performed on the 3 mm ball-like, greyish-white vascularized tumour of the iris, close to the sphincter pupillae.

Results: Light microscopy of the extirpated neoplasm showed the characteristic appearance of a leiomyoma with densely packed spindle-shaped cells, with oval nuclei and granular cytoplasm. Read More

Ophthalmology 1994 May;101(5):919-24

Department of Ocular Oncology, Moorfields Eye Hospital, London, UK.

Background: Intraocular smooth muscle tumors have long been a subject of controversy. The advent of immunohistochemistry with antibodies against HMB-45, S-100, smooth muscle actin, desmin, and vimentin has helped greatly in the distinction between smooth muscle tumors and melanocytic lesions.

Methods: Twenty-seven archival tissue blocks from patients who had had intraocular leiomyomas or leiomyosarcomas diagnosed were located and fresh sections cut and stained for the above markers. Read More

Klin Monbl Augenheilkd 1992 Nov;201(5):322-4

Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.

A 20-year-old white man demonstrated a 2-3 mm in diameter ball like, grey white vascularized tumor at 12h in the iris stroma adjacent to the sphincter pupillae OD. The tumor was excised by sector iridectomy. Light microscopically the tumor consisted of densely packed spindle-shaped cells with oval nuclei with granular eosinophilic cytoplasm. Read More

J Pediatr Ophthalmol Strabismus 1990 Nov-Dec;27(6):317-21

Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois, College of Medicine, Chicago 60612.

An 8-year-old white boy had a mass of the ciliary body in his left eye. Both the translucent characteristics and the magnetic resonance imaging findings suggested that this lesion was cystic. Fluid aspiration biopsy and iridocyclectomy were performed. Read More

Can J Ophthalmol 1989 Jun;24(4):169-71

Ivey Institute of Ophthalmology, Victoria Hospital, London, Ont.

A 77-year-old white woman presented with a lightly pigmented iris lesion assumed clinically to be an iris melanoma. Light microscopy of the excised tumour showed it to be a spindle-cell tumour. Electron microscopy confirmed the diagnosis of leiomyoma of the iris. Read More

Fortschr Ophthalmol 1989 ;86(6):631-5

The clinical, surgical and light microscopical features of a mesectodermal leiomyoma of the ciliary body are presented. Slit-lamp examination of a 63-year old woman strongly suggested a malignant lesion of the ciliary body and the peripheral choroid. Following cryoretinopexy and argonlaser-photocoagulation, the tumor and the adjacent portion of the cornea, angle structures, iris, ciliary body, choroid and sclera were removed en bloc. Read More

Graefes Arch Clin Exp Ophthalmol 1989 ;227(2):101-5

Department of Ophthalmology, Tenri Hospital, Tenri City, Japan.

The case of a 28-year-old woman with a well-vascularized, yellowish neoplasm in her right eye is reported. The findings upon slit-lamp examination and fluorescein iridography strongly suggested a malignant lesion. The tumor and the adjacent portion of the iris, angle structures, ciliary body, cornea, and sclera were removed en bloc under the half-thickness corneoscleral flap. Read More

Int Ophthalmol 1987 Oct;11(1):55-61

LSU Eye Center, Louisiana State University Medical Center, School of Medicine, New Orleans.

We used a contact Nd:YAG laser fit with a 0.2-mm diameter sapphire tip to excise a large (5 1/2 clock hour) iris ciliary body-choroidal tumor and a large (15 X 8 X 3 mm) choroidal tumor. The cutting and coagulation action of the laser helped to minimize intraoperative and postoperative hemorrhage. Read More

Arch Ophthalmol 1987 Jun;105(6):819-24

A 4-year-old boy had a jet-black, nodular lesion growing in his right iris. Detailed clinical and histopathologic studies of this unusual tumor showed the lesion to be derived from the anterior iris pigment epithelium. The tumor cells appeared to be benign and exhibited characteristics of both pigment epithelium and smooth muscle. Read More

J Comp Pathol 1987 Mar;97(2):227-9

A leiomyoma of the iris was composed of bundles of spindle-shaped cells with abundant myoglial fibres and represents the first observation of this rare tumour in a rat. Read More

Bull Soc Ophtalmol Fr 1986 Feb;86(2):161-2

Ophthalmologica 1985 ;191(2):127-9

A neoplasm of the ciliary body extending from the equator to the iris and the anterior chamber was observed in an 18-year old girl. Because the visual acuity was lost and the clinical diagnosis was uncertain the eye was enucleated. Both optic and electron microscopic investigations allowed the diagnosis of the mesectodermal type of leiomyoma of the ciliary body. Read More

Boll Soc Ital Biol Sper 1984 Jun;60(6):1253-9

Fluorangiography is a very important investigation in order to have a differential diagnosis in all pathological pattern of the conjunctiva of scleral corneal limbus of the sclera of the iris of the ciliary-body. We have in the literature two different patterns: A) Fluorescein negative pattern (cystic neoformations, benign tumors with or without pigment) B) Fluorescein positive pattern (inflammatory pseudotumors, malignant tumors). Authors agree more or less with this classification; they have, moreover, worked out some variations. Read More