22,431 results match your criteria Leiomyoma


Oestrogen receptor alpha PvuII polymorphism and uterine fibroid incidence in Caucasian women.

Prz Menopauzalny 2018 Dec 31;17(4):149-154. Epub 2018 Dec 31.

Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland.

Introduction: Uterine fibroids (UFs) are benign, monoclonal tumours of the female genital tract that originate from the myometrium. They may be diagnosed in as many as 80% of women depending on the selected population. UFs depend mostly on steroid hormones. Read More

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http://dx.doi.org/10.5114/pm.2018.81735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372853PMC
December 2018

Laparoscopic management of a large urethral leiomyoma.

Int Urogynecol J 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.

Introduction And Hypothesis: A 42-year-old female presented with a 12-cm mass bulging the anterior vaginal wall and causing urgency urinary incontinence and bulk symptoms.

Methods: Imaging showed a tumor originating from the dorsal and cranial part of the urethra and developing in the vesicouterine space and vesicovaginal septum, dislocating the bladder ventrally and the uterus cranial-dorsally.

Results: Tranvaginal biopsy showed a benign leiomyoma. Read More

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http://dx.doi.org/10.1007/s00192-019-03889-xDOI Listing
February 2019

Diagnostic Accuracy of Refractory Shadowing from Uterine Leiomyomas: Sonographic-Pathologic Correlation.

Mymensingh Med J 2019 Jan;28(1):120-125

Dr Tapashi Rahman Khan, Assistant Professor, Department Radiology and Imaging, Dhaka Community Medical College & Hospital, Mogbazar, Dhaka, Bangladesh; E-mail:

This cross sectional study was carried out in the Department of Radiology & Imaging, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh from July 2010 to June 2011 with a view to evaluate the diagnostic accuracy of refractory shadowing on transabdominal pelvic sonography for leiomyomas and in differentiating them from other pelvic masses. Histopathological examination of the surgically resected masses was taken as the standard diagnostic tool. A total number of 50 patients of pelvic masses were studied. Read More

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January 2019

Uterine Inflammatory Myofibroblastic Tumor Showing an Atypical ALK Signal Pattern by FISH and DES-ALK Fusion by RNA Sequencing: A Case Report.

Int J Gynecol Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio (S.Z., F.W.A.-K., C.A., M.L.C.P.-N.) University of Arizona College of Medicine Phoenix and Creighton University Phoenix College of Medicine (D.M.C.).

Inflammatory myofibroblastic tumors (IMTs) are spindle cell neoplasms of intermediate (borderline) biologic potential with tendency for local recurrence but low risk of metastasis. They affect children more than adults. The most common sites of involvement are the lung, soft tissue, peritoneum, bladder, and less commonly the gynecologic tract. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000588DOI Listing
February 2019
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Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome: A 5-Year Single Institutional Experience.

Am J Surg Pathol 2019 Feb 6. Epub 2019 Feb 6.

Pathology Department, University of California San Francisco.

Pathology-based screening of uterine smooth muscle tumors (uSMT) for morphology suggestive of fumarate hydratase deficiency (FH-d morphology) has been proposed as a method to identify women at increased risk for hereditary leiomyomatosis renal cell carcinoma (HLRCC) syndrome. For 5 years our clinical diagnostic practice has evaluated all women with any type of uSMT for FH-d morphology (defined, at low magnification, as staghorn shaped blood vessels and alveolar pattern edema and, at high magnification, as tumor macronucleoli surrounded by a halo and cytoplasmic eosinophilic globules) and, when present, used the pathology report to advise genetic counseling to further evaluate for HLRCC syndrome. We now report the results of this prospective screening strategy, with emphasis on the incidence and clinicopathologic features of FH-d morphology in uSMT, the rate of patient uptake of referral to genetic counseling, and the results of genetic testing for FH germline mutation. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001222DOI Listing
February 2019

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
February 2019
7 Reads

A Case of Hemoperitoneum Due to Spontaneous Bleeding from a Uterine Leiomyoma.

Am J Case Rep 2019 Feb 8;20:167-170. Epub 2019 Feb 8.

Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia.

BACKGROUND Uterine leiomyoma, or uterine fibroid, is the most common gynecologic neoplasm and its management usually results in a good clinical outcome. This report is of a rare case of hemoperitoneum associated with spontaneous hemorrhage from a benign uterine leiomyoma. CASE REPORT A 27-year-old single woman presented with generalized acute abdominal pain and vomiting. Read More

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http://dx.doi.org/10.12659/AJCR.914573DOI Listing
February 2019
1 Read

Interactome Analysis Of The Differentially Expressed Proteins In Uterine Leiomyoma.

Anticancer Agents Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062. India.

Background: Recent advances in proteomics present enormous opportunities to discover proteome related disparities and thus understanding the molecular mechanisms related to a disease. Uterine leiomyoma is a benign monoclonal tumor, located in the pelvic region, and affecting 40% of reproductive aged female.

Objective: Identification and characterization of the differentially expressed proteins associated with leiomyogenesis by comparing uterine leiomyoma and normal myometrium. Read More

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http://dx.doi.org/10.2174/1871520619666190206143523DOI Listing
February 2019

Sudden rupture with internal bleeding and shock following torsion and necrosis of a large uterine leiomyoma.

J Obstet Gynaecol 2019 Feb 4:1-3. Epub 2019 Feb 4.

a Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital , The Buddhist Tzu-Chi Medical Foundation , Taipei , Taiwan.

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http://dx.doi.org/10.1080/01443615.2018.1530203DOI Listing
February 2019

Are Fibroid and Bony Pelvis Characteristics Associated with Urinary and Pelvic Symptom Severity?

Am J Obstet Gynecol 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics & Gynecology, Stanford University School of Medicine. Electronic address:

Background: Urinary and pelvic floor symptoms are often attributed to size and location of uterine fibroids. However, direct supporting evidence linking increased size to worsening symptoms is scant and limited to ultrasound evaluation of fibroids. Because management of fibroids is targeted towards symptomatic relief, identification of fibroid and pelvic characteristics associated with worse symptoms is vital to optimizing therapies and preventing needless interventions. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.230DOI Listing
January 2019
1 Read

Evaluation and Management of Abnormal Uterine Bleeding.

Mayo Clin Proc 2019 Feb;94(2):326-335

Division of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN.

Abnormal uterine bleeding (AUB) is a common condition that leads to increased health care costs and decreased quality of life. A systematic approach to AUB evaluation can simplify management and enhance women's well-being. Abnormal uterine bleeding describes any variation from normal bleeding patterns in nonpregnant, reproductive-aged women beyond menarche lasting for at least 6 months. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183099
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http://dx.doi.org/10.1016/j.mayocp.2018.12.012DOI Listing
February 2019
1 Read

Smooth Muscle Tumors of the Visceral Adnexal and Uterine Ligaments and Adnexal Connective Tissue: A Clinicopathologic Study of 67 Cases.

Int J Gynecol Pathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (V.P., J.K.S.) Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland (D.X.) Department of Pathology, University of Florida, Gainesville, Florida (M.F.).

The endopelvic fascia is a biomechanical network of supportive tissue that suspends and secures the female reproductive organs to the pelvic sidewall. Several visceral adnexal and uterine ligaments are part of this framework, and we have observed that smooth muscle tumors (SMTs) arising from these structures morphologically resemble gynecologic smooth muscle neoplasms. To determine whether gynecologic smooth muscle tumor criteria for malignancy are valid in these tumors, we evaluated the morphologic features of 67 tumors from 67 patients and correlated our findings with patient outcome. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000578DOI Listing
January 2019
1 Read

[A STUDY OF UTERINE HEMODYNAMICS USING THREE-DIMENSIONAL POWER DOPPLER SONOGRAPHY IN PATIENTS WITH ADENOMYOSIS].

Georgian Med News 2018 Dec(285):21-27

State Institution "S.P. Hryhoriev Institute of Medical Radiology of the National Academy of Medical Sciences of Ukraine", Kharkiv; Kharkiv Medical Academy of Postgraduate Education.

The goal of the work was the investigation of volumetric blood flow parameters in uterine body of women of different ages suffering from various forms of adenomyosis, in three-dimensional angio mode, in order to search for objective differential-diagnostic criteria of this pathology. The main study group included 46 women aged 18 to 45 who were diagnosed with II-III degree adenomyosis at ultrasound examination of pelvic organs according to the conventional procedure in a two-dimensional mode. The control group included 111 healthy women aged 18 to 45 years old. Read More

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December 2018

High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis.

Cancer Manag Res 2019 17;11:831-837. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China,

Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).

Patients And Methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated. Read More

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http://dx.doi.org/10.2147/CMAR.S187849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340498PMC
January 2019
2 Reads

FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery.

Am J Obstet Gynecol 2019 Feb 26;220(2):174.e1-174.e13. Epub 2018 Oct 26.

Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN. Electronic address:

Background: Uterine leiomyomas (fibroid tumors) cause considerable symptoms in 30-50% of women and are the leading cause of hysterectomy in the United States. Women with uterine fibroid tumors often seek uterine-preserving treatments, but comparative effectiveness trials are lacking.

Objective: The purpose of this study was to report treatment effectiveness and ovarian function after uterine artery embolization vs magnetic resonance imaging-guided focused ultrasound surgery from the Fibroid Interventions: Reducing Symptoms Today and Tomorrow study. Read More

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http://dx.doi.org/10.1016/j.ajog.2018.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355152PMC
February 2019
2 Reads

[Mesenchymal and mixed uterine tumors : Current overview and practical aspects].

Authors:
S F Lax

Pathologe 2019 Feb;40(1):36-45

Institut für Klinische Pathologie und Molekularpathologie, LKH Graz II, Standort West, Akademisches Lehrkrankenhaus der Medizinischen Universität Graz, Göstinger Straße 22, 8020, Graz, Österreich.

Benign leiomyomas are the most frequent mesenchymal tumors of the uterus. In contrast, uterine sarcomas are very rare. Leiomyosarcomas are the most frequent sarcomas followed by endometrial stromal sarcomas (ESS). Read More

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http://link.springer.com/10.1007/s00292-019-0567-6
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http://dx.doi.org/10.1007/s00292-019-0567-6DOI Listing
February 2019
3 Reads

Retrospective characterization of reproductive tract lesions in relation to age, parity, and contraception in captive suidae and tayassuidae.

Theriogenology 2019 Mar 18;127:137-144. Epub 2019 Jan 18.

Department of Veterinary Physiology and Pharmacology, 4466 TAMU Texas A&M University, College Station, TX, 77843, USA. Electronic address:

Reproductive management in zoos requires contraception or physical separation of sexes to ensure captive population viability, but information is sparse on the effects of parity, age, and contraceptive use on lifetime reproductive health in captive Suidae and Tayassuidae species. This retrospective study evaluated reproductive tissues and histories from babirusa (Babyrousa babyrussa), red river hog (Potamochoerus porcus), Visayan warty pig (Sus cebifrons), common warthog (Phacochoerus africanus), Vietnamese pot-bellied pig (Sus scrofa domesticus), domestic cross pig (Sus scrofa), Sunda island pig (Sus celebensis timoriensis), Eurasian boar (Sus scrofa), Bornean bearded pig (Sus barbatus), Ossabaw island hog (Sus scrofa domesticus), Guinea hog (Sus scrofa domesticus), Chacoan peccary (Catagonus wagneri), and collared peccary (Pecari tajacu). Age, parity, litter size, time-since-last-parturition, contraception exposure and type, and lesion prevalence were recorded. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.012DOI Listing
March 2019
2 Reads

Massive prolapsed submucous fibroid treated with laparoscopic surgery: A case report.

J Obstet Gynaecol Res 2019 Jan 25. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Prolapsed uterine fibroids are pedunculated submucous fibroids that prolapse through the cervical canal. Herein, we describe the laparoscopic treatment of massive prolapsed submucous fibroids. A 47-year-old woman had experienced frequent urination and abnormal vaginal bleeding for 7 years. Read More

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http://dx.doi.org/10.1111/jog.13901DOI Listing
January 2019
2 Reads

Nonresective treatments for uterine fibroids: a systematic review of uterine and fibroid volume reductions.

Int J Hyperthermia 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Gynaecology , St Mary's Hospital, Imperial College Healthcare Trust , London , UK.

Patients are increasingly seeking uterus-preserving, minimally invasive treatments for symptomatic uterine fibroids. This has led to a greater use of nonresective treatments such as uterine artery embolization (UAE), focused ultrasound (FUS) and more recently, radiofrequency ablation (RFA) of fibroids. This systematic review, following PRISMA guidelines, examines the change in uterine and fibroid volumes associated with UAE, FUS, and RFA. Read More

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http://dx.doi.org/10.1080/02656736.2018.1564843DOI Listing
January 2019

[Relationship between activation of endometrial CD56+ natural killers and the character of leiomyoma nodules growth in patients with uterine leiomyoma.]

Klin Lab Diagn 2018 ;63(2):119-123

Federal State Budgetary Establishment "Research Institute of Maternity and Childhood named V.N. Gorodkov" of the Ministry of Health of the Russian Federation, 153045, Ivanovo, Russia.

In patients with different clinical variants of uterine leiomyoma (large or small size, presence or absence of intensive proliferation of tumor cells) the comparative analysis of endometrial CD56+ natural killers (NK) activation was carried out. The relative content of CD56+ cells, expressing of CD158a and CD158i molecules from KIR (killer immunoglobuline-like receptors) family, interferon γ (IFNγ) and transforming growth factor β1 (TGFβ1), was estimated by flow cytometry method. It was found that in the endometrium of all patients with uterine leiomyoma independently of tumor size the content of CD56+ cells and the amount of NK, expressing both activating (CD158i) and inhibitory (CD158a) receptors, were increased. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-2-119-123DOI Listing
January 2018

[Leiomyoma of the esophagus : A further indication for robotic surgery?]

Chirurg 2019 Feb;90(2):125-130

Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Paracelsus Medizinische Privatuniversität Nürnberg, Prof.-Ernst-Nathan-Straße 1, 90419, Nürnberg, Deutschland.

Background: Leiomyomas of the esophagus are rare tumors but the most common benign lesion of the esophagus originating from smooth muscle cells. The symptoms are mainly determined by the size of the tumor and are caused by dysphagia and/or retrosternal pain. The majority of patients are however asymptomatic. Read More

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http://dx.doi.org/10.1007/s00104-019-0792-9DOI Listing
February 2019

Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report.

Iran J Med Sci 2019 Jan;44(1):60-64

Department of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.

Leiomyomatosis peritonealis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to leiomyoma and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we describe a 46-year-old woman, diagnosed with LPD, to demonstrate the etiopathogenesis of the developed leiomyomatosis following endoscopic extirpation of the uterus with the use of a power morcellator. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330526PMC
January 2019
4 Reads

Abnormal hysteroscopy findings among a cross section of infertile Nigerian women.

Niger J Clin Pract 2019 Jan;22(1):9-15

Department of Obstetrics and Gynaecology, University of Portharcout Teaching Hospital, Port Harcourt, Nigeria.

Background: Intrauterine lesions are important causes of infertility. This study aims to evaluate the abnormal findings at hysteroscopy among infertile women seen in 2 new Fertility/Gynaecological Endoscopy units in Nigeria.

Methods: A prospective study of 159 infertile women who had diagnostic hysteroscopy in Nnamdi Azikiwe University Teaching hospital Nnewi and Holy Rosary Specialist Hospital, Onitsha to evaluate the intrauterine lesions seen. Read More

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http://dx.doi.org/10.4103/njcp.njcp_404_17DOI Listing
January 2019
4 Reads

Successful en bloc endoscopic full-thickness resection of a giant cervical esophageal leiomyoma originating from muscularis propria.

J Cardiothorac Surg 2019 Jan 21;14(1):16. Epub 2019 Jan 21.

Department of Gastroenterology, People's Hospital of Lianshui, 6 Hongri Road, Huaian, China.

Background: Esophageal leiomyomas, the most common benign primary tumors of the esophagus, are esophageal subepithelial lesions treated by surgery traditionally. In recent years, endoscopic submucosal dissection and related endoscopic treatment techniques are adopted by endoscopists to resect gastrointestinal submucosal tumors. But if a giant esophageal leiomyoma approaches the esophagus entrance and originates from the deep layer of muscularis propria, it will be difficult for both endoscopic resection and surgical treatment. Read More

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https://cardiothoracicsurgery.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13019-019-0847-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341741PMC
January 2019
4 Reads

Nipple leiomyoma: A rare neoplasm with a broad spectrum of histologic appearances.

J Cutan Pathol 2019 Jan 20. Epub 2019 Jan 20.

Department of Pathology, Oregon Health & Science University, Portland, Oregon.

Cutaneous leiomyomas are rare benign smooth-muscle tumors. These lesions are distinguished based on their cell of origin and are subclassified as pilar leiomyoma, angioleiomyoma, and genital-type leiomyoma. Nipple leiomyoma is the least common genital-type leiomyoma, arising from the dartoic muscle cell of the nipple. Read More

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http://dx.doi.org/10.1111/cup.13423DOI Listing
January 2019
1 Read

Machine Learning to Differentiate T2-Weighted Hyperintense Uterine Leiomyomas from Uterine Sarcomas by Utilizing Multiparametric Magnetic Resonance Quantitative Imaging Features.

Acad Radiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Rationale And Objective: Uterine leiomyomas with high signal intensity on T2-weighted imaging (T2WI) can be difficult to distinguish from sarcomas. This study assessed the feasibility of using machine learning to differentiate uterine sarcomas from leiomyomas with high signal intensity on T2WI on multiparametric magnetic resonance imaging.

Materials And Methods: This retrospective study included 80 patients (50 with benign leiomyoma and 30 with uterine sarcoma) who underwent pelvic 3 T magnetic resonance imaging examination for the evaluation of uterine myometrial smooth muscle masses with high signal intensity on T2WI. Read More

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http://dx.doi.org/10.1016/j.acra.2018.11.014DOI Listing
January 2019
1 Read

Surgical outcomes after uterine artery occlusion at the time of myomectomy: systematic review and meta-analysis.

Fertil Steril 2019 Jan 17. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Mount Sinai Hospital and Women's College Hospital, and Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To systematically review and meta-analyze evidence on surgical outcomes after uterine artery occlusion (UAO) at myomectomy.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183229
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http://dx.doi.org/10.1016/j.fertnstert.2018.12.011DOI Listing
January 2019
4 Reads

Analysis of uterine corporeal mesenchymal tumors occurring after menopause.

BMC Womens Health 2019 Jan 18;19(1):13. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Yokohama Municipal Citizen's Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555, Japan.

Objective: Because it is difficult to diagnose accurately whether uterine corporeal mesenchymal tumors are benign or malignant before surgery, an understanding of the characteristics of patients with uterine sarcomas occurring in the postmenopausal period is required.

Methods: We retrospectively reviewed the cases of women who underwent surgery for uterine mesenchymal tumors at our hospital.

Results: Among 487 operated cases, 447 tumors occurred in the premenopausal period and 40 occurred in the postmenopausal period. Read More

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http://dx.doi.org/10.1186/s12905-019-0714-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339291PMC
January 2019
2 Reads

Two cases of acute urinary retention caused by large cervical leiomyoma with review of literature.

J Exp Ther Oncol 2019 Jan;13(1):41-43

University of Health Science, Zekai Tahir Burak Woman's Health, Education and Research Hospital, Ankara, Turkey.

Objective: Large uterine or cervical leiomyomas may cause acute urinary retention due to bladder outlet obstruction. We report two cases with acute urinary retention caused by cervical leiomyoma. Myomectomies were performed due to their desire of fertility and frozen-section examinations were reported as benign leiomyomas in both cases. Read More

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January 2019
5 Reads

Susceptibility weighted MRI after uterine artery embolization for leiomyoma.

Magn Reson Imaging 2019 Jan 15;58:32-37. Epub 2019 Jan 15.

Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

Purpose: To evaluate whether susceptibility-weighted MR imaging (SWI) findings are associated with tumor infarction on contrast-enhanced MRI (CE-MRI) after uterine artery embolization (UAE) for leiomyoma.

Methods: This was a single institution, retrospective study. Between February 2016 and April 2017, 27 consecutive patients underwent UAE and completed SWI and CE-MRI before and 1 week after UAE. Read More

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http://dx.doi.org/10.1016/j.mri.2019.01.013DOI Listing
January 2019

Suspected Hypercalcemia of Benignancy Associated with Canine Vaginal Leiomyoma.

J Am Anim Hosp Assoc 2019 Jan 17. Epub 2019 Jan 17.

From IDEXX Reference Laboratories, Inc., Napa, California (S.S., R.L.); and Kyle Animal Hospital, Kyle, Texas (C.L.).

Hypercalcemia was identified in a canine patient with a benign vaginal leiomyoma. Subsequent diagnostic workup did not reveal hypercalcemia of malignancy. Surgical resection of the leiomyoma resulted in a conversion to normocalcemic status. Read More

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http://dx.doi.org/10.5326/JAAHA-MS-6828DOI Listing
January 2019
1 Read

Nonthrombotic pulmonary embolism caused by intravenous leiomyomatosis: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14118

Heart Center, Cheng-Hsin General Hospital, Taipei.

Rationale: Pulmonary embolism is a potentially devastating medical condition. Although deep-vein thrombosis is the most common etiology, a nonthrombotic pulmonary embolism is not uncommon.

Patient Concerns: A 45-year-old woman was admitted to our hospital for progressive effort dyspnea for 3 weeks. Read More

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http://dx.doi.org/10.1097/MD.0000000000014118DOI Listing
January 2019
2 Reads

Imaging features of uterine and ovarian fibromatosis in Nevoid Basal Cell Carcinoma Syndrome.

J Radiol Case Rep 2018 Sep 30;12(9):21-30. Epub 2018 Sep 30.

Department of Radiology, Azienda Ospedaliero-Universitaria Policlinico di Modena, Italy.

Gorlin-Goltz Syndrome also known as Nevoid Basal Cell Carcinoma Syndrome is an autosomal dominant multisystem disorder. It is characterized by basal cell carcinomas, odontogenic keratocysts, skeletal abnormalities and in a minority of female patients bilateral calcified ovarian fibromas. It is challenging to radiologically assess ovarian fibromas as they have similar imaging patterns to some malignant ovarian lesions. Read More

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http://dx.doi.org/10.3941/jrcr.v12i9.3390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312044PMC
September 2018
1 Read

Skull base angiomatous leiomyoma: a case report and review of literature.

Br J Neurosurg 2019 Jan 12:1-3. Epub 2019 Jan 12.

b Department of Neurosurgery , Royal Hallamshire Hospital , Sheffield , UK.

Leiomyomas, benign neoplasms of mesenchymal origin, are common in gastrointestinal and genitourinary tracts. They are comprised of well-differentiated smooth muscle cells with few mitotic figures. Leiomyomas should not exhibit metastatic potential, though metastasis has been reported. Read More

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http://dx.doi.org/10.1080/02688697.2018.1555636DOI Listing
January 2019
4 Reads

Hydropic leiomyoma presenting as a rare condition of pseudo-Meigs syndrome: literature review and a case of a pseudo-Meigs syndrome mimicking ovarian carcinoma with elevated CA125.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Medicine, QE2 Health Science Center, Halifax, Nova Scotia, Canada.

The clinical scenario of a female patient with a pelvic mass, elevated CA125 tumour marker, pleural effusion and ascites is often associated with malignancy. However, not all cases are malignant. Non-malignant diseases, such as Meigs syndrome and pseudo-Meigs syndrome, must be part of your differential. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22645
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http://dx.doi.org/10.1136/bcr-2018-226454DOI Listing
January 2019
4 Reads

Postoperative pain control with ropivacaine following laparoscopic myomectomy: A randomized double-blind, pilot study.

J Obstet Gynaecol Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynaecology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea.

Aim: The aim of this study was to evaluate immediate pain control in patients who underwent laparoscopic myomectomy (LM) by intraoperative injection of ropivacaine into both uterosacral ligaments.

Methods: The study was a prospective, double-blind, randomized study. We analyzed 46 cases of LM performed between July 2015 and November 2016 by a single surgeon. Read More

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http://dx.doi.org/10.1111/jog.13910DOI Listing
January 2019
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Submucosal Tunnel Endoscopic Resection for Esophageal Submucosal Tumors: A Multicenter Study.

Gastroenterol Res Pract 2018 2;2018:2149564. Epub 2018 Dec 2.

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Submucosal tumors (SMTs) are primarily benign tumors, but some may have a malignant potential. Endoscopic submucosal dissection that has been used for removing esophageal SMTs could cause perforation. Submucosal tunnel endoscopic resection (STER) is an improved and an effective technique for treating esophageal SMTs. Read More

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http://dx.doi.org/10.1155/2018/2149564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304882PMC
December 2018
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Diagnostic ambiguity of aseptic necrobiosis of a uterine fibroid in a term pregnancy: a case report.

BMC Pregnancy Childbirth 2019 Jan 7;19(1). Epub 2019 Jan 7.

Departement of Surgery and Specialities, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.

Background: Uterine fibroids are the most common uterine tumours in females of reproductive age. During pregnancy, uterine fibroids may be complicated by aseptic necrobiosis. We herein report an ambiguous clinical presentation of uterine fibroids in pregnancy and discuss the diagnostic challenges encountered in our resource-constraint setting. Read More

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http://dx.doi.org/10.1186/s12884-018-2154-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323858PMC
January 2019
2 Reads
2.190 Impact Factor

Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways.

Mol Cell Endocrinol 2019 Mar 4;484:59-68. Epub 2019 Jan 4.

Molecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA. Electronic address:

The role of ERα36 in regulating BPA's effects and its potential as a risk factor for human uterine fibroids were evaluated. BPA at low concentrations (10 μM - 10 μM) increased proliferation by facilitating progression of hormonally regulated, immortalized human uterine leiomyoma (ht-UtLM; fibroid) cells from G-G into S phase of the cell cycle; whereas, higher concentrations (100 μM-200 μM) decreased growth. BPA upregulated ERα36 gene and protein expression, and induced increased SOS1 and Grb2 protein expression, both of which are mediators of the MAPK/ERK1/2 pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03037207193000
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http://dx.doi.org/10.1016/j.mce.2019.01.001DOI Listing
March 2019
3 Reads

Metabolomic Biomarkers in Gynecology: a Treasure Path or a False Path?

Curr Med Chem 2019 01 4. Epub 2019 Jan 4.

Institute of Perinatology and Pediatric, Almazov National Medical Research Centre . Russian Federation.

Omic-technologies (genomics, transcriptomics, proteomics and metabolomics) have become more important in current medical science. Among them, it is metabolomics that most accurately reflects the minor changes in body functioning, as it focuses on metabolome - the group of the metabolism products, both intermediate and end. Therefore, metabolomics is actively engaged in fundamental and clinical studies and search for potential biomarkers. Read More

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http://dx.doi.org/10.2174/0929867326666190104124245DOI Listing
January 2019
4 Reads

Per oral endoscopic tumor (POET) resection for treatment of upper gastrointestinal subepithelial tumors.

Surg Endosc 2019 Jan 2. Epub 2019 Jan 2.

Division of Upper GI and Metabolic Surgery, Department of Surgery and State Key Laboratory of Digestive Diseases, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong S.A.R., The People's Republic of China.

Background: Endoscopic submucosal tunneling has evolved to allow endoscopic resection of subepithelial tumors of gastrointestinal tract without full-thickness perforation. This study aimed to investigate safety and efficacy of submucosal tunnel resection for these tumors.

Method: Patients with subepithelial tumors (SET) located in esophagus, gastric cardia, lesser curvature, and antrum were recruited. Read More

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http://link.springer.com/10.1007/s00464-018-06627-4
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http://dx.doi.org/10.1007/s00464-018-06627-4DOI Listing
January 2019
5 Reads

Intra-leiomyoma hemorrhage in postmenopausal woman presented with acute abdominal pain.

J Family Med Prim Care 2018 Sep-Oct;7(5):1129-1132

Department of Obstetrics and Gynecology, Royal Medical Services, Amman, Jordan.

Intra-leiomyoma hemorrhage in postmenopausal woman is a very rare complication. This case report represents a case report of spontaneous hemorrhage inside the uterine leiomyoma in postmenopausal woman who presented with acute abdomen. A 55-year-old woman, multipara, postmenopausal for 7 years, known case of multiple fibroid uteruses, was presented to the emergency department of Ahmadi Hospital, Kuwait Oil Company, with acute abdominal pain and vomiting, without any reported trauma and/or associated vaginal bleeding. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_215_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259501PMC
January 2019
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Ultrasonographic characterisation of obstructive uropathy in Nigerian women with uterine fibroids.

Niger Postgrad Med J 2018 Oct-Dec;25(4):220-224

Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

Objectives: The objective of this study was to determine the prevalence of upper renal tract obstructive changes in women with uterine fibroids using ultrasonography (USG).

Methods: We enrolled 140 women with uterine fibroids and performed USG of the uterus and upper renal tract with full and empty urinary bladders, respectively. The number of fibroid nodules and the uterine volume were determined. Read More

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http://dx.doi.org/10.4103/npmj.npmj_122_18DOI Listing
December 2018
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Development of a Model for the Prediction of Treatment Response of Uterine Leiomyomas after Uterine Artery Embolization.

Int J Med Sci 2018 23;15(14):1771-1777. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Uterine artery embolization (UAE) is one of the minimally-invasive alternatives to hysterectomy for treatment of uterine leiomyomas. There are various factors affecting the outcomes of UAE, but these have only been sporadically studied. To identify factors associated with the efficacy of UAE for the treatment of uterine leiomyoma, and to develop a model for the prediction of treatment response of uterine leiomyomas to UAE. Read More

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http://dx.doi.org/10.7150/ijms.28687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299417PMC
November 2018
4 Reads

N 371 - Le morcellement durant la chirurgie gynécologique: Son utilisation, ses complications et les risques liés à la présence de tumeurs malignes insoupçonnées.

J Obstet Gynaecol Can 2019 Jan;41(1):127-138

London (Ont.).

Objectif: La présente directive clinique conseille les gynécologues quant au recours au morcellement tissulaire pendant une chirurgie gynécologique. RéSULTATS: Le morcellement effectué au cours d'une chirurgie gynécologique peut permettre l'ablation de masses utérines volumineuses, offrant ainsi aux femmes une solution chirurgicale à effraction minimale. Les conséquences oncologiques indésirables du morcellement tissulaire devraient être atténuées par l'amélioration de la sélection des patientes, la tenue d'examens préopératoires et l'adoption de techniques novatrices réduisant au minimum la dispersion tissulaire. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.017DOI Listing
January 2019
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No. 371-Morcellation During Gynaecologic Surgery: Its Uses, Complications, and Risks of Unsuspected Malignancy.

J Obstet Gynaecol Can 2019 Jan;41(1):116-126

London ON.

Objective: This guideline provides guidance to gynaecologists regarding the use of tissue morcellation in gynaecologic surgery.

Outcomes: Morcellation may be used in gynaecologic surgery to allow removal of large uterine specimens, thus providing women with a minimally invasive surgical option. Adverse oncologic outcomes of tissue morcellation should be mitigated through improved patient selection, preoperative investigations, and novel techniques that minimize tissue dispersion. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.07.016DOI Listing
January 2019
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Calcified leiomyoma of the uterus following brachytherapy.

Authors:
Mohamed Iliyas

Postgrad Med J 2018 Dec 21. Epub 2018 Dec 21.

Department of General Medicine, Shri Sathya Sai Medical College and Research Institute, Kanchipuram, TN 603108, India

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http://dx.doi.org/10.1136/postgradmedj-2018-135996DOI Listing
December 2018
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Can single disease payment system based on clinical pathway reduce hospitalization costs in rural area? A case study of uterine leiomyoma in Anhui, China.

BMC Health Serv Res 2018 Dec 20;18(1):990. Epub 2018 Dec 20.

School of Health Service Management, Anhui Medical University, Hefei, 230000, Anhui, China.

Background: Single disease payment program based on clinical pathway (CP-based SDP) plays an increasingly important role in reducing health expenditure in china and there is a clear need to explore the scheme from different perspectives. This study aimed at evaluating the effect of the scheme in rural county public hospitals within Anhui, a typical province of China,using uterine leiomyoma as an example.

Methods: The study data were extracted from the data platform of the New Rural Cooperative Medical Office of Anhui Province using stratified-random sampling. Read More

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http://dx.doi.org/10.1186/s12913-018-3807-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302448PMC
December 2018
1 Read