22,561 results match your criteria Leiomyoma


Primary intracranial leiomyoma - A case report and literature review.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):72-76

Department of Radiology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.

Primary intracranial leiomyoma is a rare tumour of mesenchymal origin, with less than 30 cases reported in literature including two cases from the Indian subcontinent. In this article, we describe a case of primary intracranial leiomyoma in an immunocompromised patient with a brief review of literature. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_250_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467049PMC

Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.

Mol Biol Rep 2019 Apr 13. Epub 2019 Apr 13.

Department of Biological and Chemical Sciences, Faculty of Science and Technology, University of the West Indies Cave Hill Campus, Bridgetown, Barbados.

Uterine leiomyomas (UL) are prevalent benign tumors, especially among women of African ancestry. The disease also has genetic liability and is influenced by risk factors such as hormones and obesity. This study investigates the haplotypes of the Cytochrome P450 1B1 gene (CYP1B1) related to hormones and coiled-coil domain containing 57 gene (CCDC57) related to obesity in Afro-Caribbean females. Read More

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http://link.springer.com/10.1007/s11033-019-04790-y
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http://dx.doi.org/10.1007/s11033-019-04790-yDOI Listing
April 2019
1 Read

Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature.

Respir Med Case Rep 2019 28;27:100831. Epub 2019 Mar 28.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA.

Benign metastasizing leiomyoma (BML) is a rare benign smooth muscle neoplasm that originates in the uterus and metastasizes to distant sites-most commonly the lungs. BMLs are often found incidentally in patients with a history of uterine leiomyoma(s) and tend to be indolent. Occasionally they may be symptomatic and rarely follow an aggressive clinical course. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446132PMC
March 2019
1 Read

Aberrant Hypermetabolism of Benign Uterine Leiomyoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Gynecologic Oncology-Hospital Sírio-Libanês, São Paulo, Brazil.

Leiomyomas are prevalent benign smooth muscle tumors in the uterus, displaying variable degrees of FDG uptake on PET/CT. The glucose metabolism intensity of those lesions relies on biologic features and markedly increased FDG accumulation is more typically related to malignant diseases, as in the case of leiomyosarcomas. Notwithstanding that uterine fibroids typically exhibit mild to moderate FDG uptake, in this article we report a case of unexpectedly intense hypermetabolism of a benign uterine leiomyoma on a PET/CT scan performed for initial staging of a breast cancer patient. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002580DOI Listing
April 2019
3 Reads

Transcriptome Analysis of mRNA in Uterine Leiomyoma Using Next-Generation RNA Sequencing.

Anticancer Agents Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062. India.

Background: Uterine leiomyoma is a benign smooth muscle tumor of monoclonal nature in female reproductive tract and is one of the major health problems. More than 70% of female population suffers from uterine leiomyoma in their lifetime and in advanced condition it is associated with pregnancy complications and infertility.

Objective: Characterization and relative expression of mRNA transcripts through transcriptome profiling in uterine leiomyoma and adjacent myometrium. Read More

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http://dx.doi.org/10.2174/1871520619666190409102855DOI Listing
April 2019
2 Reads

Outcomes of Myomectomy at the Time of Cesarean Section among Pregnant Women with Uterine Fibroids: A Retrospective Cohort Study.

Biomed Res Int 2019 10;2019:7576934. Epub 2019 Mar 10.

Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Objective: A retrospective study was performed to evaluate the safety and feasibility of cesarean myomectomy among pregnant women with uterine fibroids (UFs).

Methods: Upon data collection, the pregnant women with UF underwent cesarean section in the 39 hospital divided into two groups: cesarean myomectomy group, receiving cesarean section and myomectomy; cesarean group, receiving cesarean section only. Information about the type, location, and number of UFs was collected from the medical records or the prenatal ultrasound examinations. Read More

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https://www.hindawi.com/journals/bmri/2019/7576934/
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http://dx.doi.org/10.1155/2019/7576934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431434PMC
March 2019
4 Reads

Insufficient Leiomyoma Infarction in Uterine Artery Embolization: Relationship with Tumor Location.

J Vasc Interv Radiol 2019 Apr 2. Epub 2019 Apr 2.

Department of Radiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, Japan.

Purpose: To evaluate which leiomyoma location in the uterus predicts insufficient tumor infarction after uterine artery embolization (UAE).

Materials And Methods: In this single-institution retrospective study, 45 patients (mean age, 43.4 y ± 4. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.11.041DOI Listing
April 2019
1 Read

Laparoscopic management of uncommon benign uterine tumors: a systematic review.

Updates Surg 2019 Apr 2. Epub 2019 Apr 2.

Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.

The objective of the study was to review the reported cases of uncommon benign uterine tumors managed by laparoscopy. Medline database was searched using predefined search terms linked to atypical leiomyomas, leiomyoma variants, laparoscopy and morcellation. Quality of articles was assessed using Joanna Briggs Institute (JBI) critical appraisal tool. Read More

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http://dx.doi.org/10.1007/s13304-019-00651-2DOI Listing
April 2019
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Clinical Outcomes of Minimally Invasive Enucleation of Leiomyoma of the Esophagus and Esophagogastric Junction.

J Gastrointest Surg 2019 Apr 2. Epub 2019 Apr 2.

Department of Biomedical Sciences for Health, Division of General Surgery, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.

Objective: Minimally invasive enucleation is the treatment of choice in symptomatic patients with esophageal leiomyoma. Comprehensive long-term follow-up data are lacking. Aim of this study was to review the clinical outcomes of three procedures for enucleation of leiomyoma of the esophagus and esophagogastric junction. Read More

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http://dx.doi.org/10.1007/s11605-019-04210-3DOI Listing
April 2019
4 Reads

Racial Disparities in Response to an FDA Safety Communication Regarding the Use of Power Morcellation for the Treatment of Uterine Leiomyoma.

J Minim Invasive Gynecol 2019 Mar 29. Epub 2019 Mar 29.

Department of Surgery, Johns Hopkins University School of Medicine.

Study Objective: To investigate whether the rate of increase in the performance of abdominal myomectomy over a laparoscopic approach after the U.S. Food and Drug Administration (FDA) safety communication regarding morcellator use for myomectomy differs among races. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.03.019DOI Listing
March 2019
2 Reads

Abnormal Uterine Bleeding in Premenopausal Women.

Am Fam Physician 2019 Apr;99(7):435-443

University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Abnormal uterine bleeding is a common symptom in women. The acronym PALM-COEIN facilitates classification, with PALM referring to structural etiologies (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia), and COEIN referring to nonstructural etiologies (coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, not otherwise classified). Evaluation involves a detailed history and pelvic examination, as well as laboratory testing that includes a pregnancy test and complete blood count. Read More

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April 2019
2 Reads

Partial cystectomy in young male for a urachal tumor masquerading a bladder leiomyoma.

Arch Ital Urol Androl 2019 Mar 29;91(1):51-52. Epub 2019 Mar 29.

Department of Surgery, University of Naples Federico II, Naples.

Leiomyoma of the bladder is a very rare disorder that accounts for 0.43% of all bladder neoplasms. Although the pathophysiology of the bladder leiomyoma is unknown, there are some theories on it. Read More

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http://dx.doi.org/10.4081/aiua.2019.1.51DOI Listing
March 2019
1 Read

A rare cause of adult ileocolic intussusception: ileal leiomyoma.

BJR Case Rep 2018 Dec 24;4(4):20170094. Epub 2018 May 24.

Diagnostic Imaging Department, Monash Health, Melbourne, VIC, Australia.

Intussusception is a rare condition in adulthood and, unlike in children, is usually caused by an identifiable underlying lesion, most commonly a gastrointestinal tumour. The clinical presentation is non-specific and often there are intermittent symptoms making the diagnosis difficult based solely on history and examination. Plain radiography may reveal signs of bowel obstruction, however, CT is the gold standard to diagnose and localise an intussusception in adults. Read More

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http://dx.doi.org/10.1259/bjrcr.20170094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438405PMC
December 2018
1 Read

Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity.

Authors:
Malcolm G Munro

Fertil Steril 2019 Apr;111(4):629-640

Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Obstetrics and Gynecology, Kaiser-Permanente, Los Angeles Medical Center, Los Angeles, California. Electronic address:

Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are "innocent bystanders" unrelated to the problem at hand. Although removing an endometrial polyp may be seen as a relatively benign and safe intervention, myomectomy, and in particular adenomyomectomy, can be substantive surgical procedures, associated with their own potential for disrupting fertility. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282193011
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http://dx.doi.org/10.1016/j.fertnstert.2019.02.008DOI Listing
April 2019
9 Reads

Laparoscopic myomectomy: an alternative approach to tackling submucous fibroids?

J Minim Invasive Gynecol 2019 Mar 26. Epub 2019 Mar 26.

Department of Women's Health, Whipps Cross Hospital, Barts Health NHS Trust, Whipps Cross Road, London, E11 1NR.

Study Objective: To evaluate the differences in peri-operative outcomes and immediate complication rates between laparoscopic myomectomy for submucous fibroids and laparoscopic myomectomy for fibroids in other locations.

Design: Retrospective cohort study SETTING: University-affiliated hospital in London, UK PATIENTS: Three hundred fifty patients with symptomatic uterine fibroids underwent laparoscopic myomectomy. Thirty-three of these were performed for submucous fibroids (group 1), three hundred seventeen were for fibroids in other uterine locations (group 2). Read More

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http://dx.doi.org/10.1016/j.jmig.2019.03.015DOI Listing

Noninvasive prediction model for diagnosing gastrointestinal stromal tumors using contrast-enhanced harmonic endoscopic ultrasound.

Dig Liver Dis 2019 Mar 26. Epub 2019 Mar 26.

Department of Internal Medicine, Yonsei University College of Medicine, 03722, Seodaemun-gu, Seoul, Republic of Korea; Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background & Aims: Subepithelial tumors (SETs) are difficult to diagnose accurately without invasive pathological confirmation. We created a noninvasive prediction model for diagnosing gastrointestinal stromal tumors (GISTs) using contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS).

Methods: We retrospectively reviewed 176 patients who underwent CEH-EUS from October 2011 to August 2017. Read More

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http://dx.doi.org/10.1016/j.dld.2019.02.017DOI Listing
March 2019
1 Read

Leiomyoma of the External Auditory Canal.

J Int Adv Otol 2019 Mar 29. Epub 2019 Mar 29.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Angioleiomyomas (ALMAs) are benign tumors that arise from smooth muscle cells that form the tunica media of vascular structures. To our knowledge, only five cases of ALMA of the external auditory canal (EAC) have been reported. We report the case of a 52-year-old man with left otalgia, otorrhea, auricular fullness, and hearing loss. Read More

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http://dx.doi.org/10.5152/iao.2019.4743DOI Listing
March 2019
1 Read

Adenomyosis:A Clinico-pathological Study.

West Afr J Med 2019 Jan-Apr;36(1):88-92

Department of Histopathology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Background: Adenomyosis is defined by the presence within the myometrium of benign endometrial glands and stroma. Several theories have evolved to explain the pathogenesis of adenomyosis. A third of adenomyosis cases are asymptomatic. Read More

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March 2019
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Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer.

JAMA Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands.

Importance: Survivors of childhood cancer (CCSs) face risk of developing subsequent tumors. Solid benign tumors may be cancer precursors; benign tumors and cancers may share etiologic factors. However, comprehensive data on the risk for solid benign tumors are lacking. Read More

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http://dx.doi.org/10.1001/jamaoncol.2018.6862DOI Listing
March 2019
4 Reads

Recent advances in understanding and managing adenomyosis.

F1000Res 2019 13;8. Epub 2019 Mar 13.

Obstetrics and Gynecology, Department of Maternity and Child Health, University Hospital Florence, Careggi University Hospital, Florence, Largo Brambilla 3, 50134, Italy.

Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are pathologically demonstrated in the uterine myometrium and it is considered a specific entity in the PALM-COEIN FIGO (polyp; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic; and not yet classified - International Federation of Gynecology and Obstetrics) classification of causes of abnormal uterine bleeding (AUB). Although it has always been considered the classic condition of multiparous women over 40 years old who have pain and heavy menstrual bleeding, diagnosed at hysterectomy, the epidemiological scenario has completely changed. Adenomyosis is increasingly identified in young women with pain, AUB, infertility, or no symptoms by using imaging techniques such as transvaginal ultrasound and magnetic resonance. Read More

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http://dx.doi.org/10.12688/f1000research.17242.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419978PMC
March 2019
2 Reads

Genome-wide profiling of miRNA expression patterns in tubal endometriosis.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

J Zhang, Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200030, China.

MicroRNA (miRNA) expression profiles in tubal endometriosis (EM) are still poorly understood. In this study, we analyzed the differential expression of miRNAs and the related gene networks and signaling pathways in tubal EM. Four tubal epithelium samples from tubal EM patients and five normal tubal epithelium samples from uterine leiomyoma patients were collected for miRNA microarray. Read More

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http://dx.doi.org/10.1530/REP-18-0631DOI Listing
March 2019
1 Read
3.174 Impact Factor

More Than a Myoma: A Review of Myomatous Erythrocytosis Syndrome.

J Obstet Gynaecol Can 2019 Mar 20. Epub 2019 Mar 20.

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC; Vancouver Island Health Authority, Victoria General Hospital, Victoria, BC.

Myomatous erythrocytosis syndrome (MES) is gynaecological condition marked by isolated erythrocytosis and a fibroid uterus. This report presents a case of MES and reviews common clinical presentations, hematological trends, and patient outcomes. This study was a combined case report and review of published cases of MES. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.12.025DOI Listing

Small soft tissue masses indeterminate at imaging: histological diagnoses at a tertiary orthopedic oncology clinic.

Skeletal Radiol 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, JMH WW 279, Miami, FL, 33136, USA.

Objective: To review histologic diagnoses of soft-tissue masses (STMs) ≤ 2 cm with indeterminate imaging features encountered in musculoskeletal oncology clinic at a tertiary referral center.

Materials And Methods: This was an IRB-approved retrospective review of patients with STMs ≤ 2 cm, referred to our tertiary care orthopedic oncology clinic over 4.75 consecutive years. Read More

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http://link.springer.com/10.1007/s00256-019-03205-0
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http://dx.doi.org/10.1007/s00256-019-03205-0DOI Listing
March 2019
7 Reads

mutations and fumarate hydratase inactivation in uterine adenomyomas.

Hum Reprod Open 2018 17;2018(4):hoy020. Epub 2018 Nov 17.

Research Programs Unit, Genome-Scale Biology Research Program and Medicum, Department of Medical and Clinical Genetics., FIN-00014 University of Helsinki, Helsinki, Finland.

Study Question: Do the uterine leiomyoma driver events - mediator complex subunit 12 () mutations, high mobility group AT-hook (HMGA2) overexpression, and fumarate hydratase (FH) inactivation - also contribute to the development of uterine adenomyomas?

Summary Answer: mutations and FH deficiency occur in a subset of uterine adenomyomas, but at lower frequencies than in leiomyomas.

What Is Known Already: Uterine adenomyomas are benign tumours with clinical features very similar to uterine leiomyomas. Mutations affecting , and account for up to 80-90% of leiomyomas, but their contribution to adenomyomas is not known. Read More

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http://dx.doi.org/10.1093/hropen/hoy020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276694PMC
November 2018
4 Reads

Non-puerperal uterine inversion associated with myomatosis.

Rev Assoc Med Bras (1992) 2019 Feb;65(2):130-135

Physician and resident in Gynecology and Obstetrics at Hospital Universitário da Universidade Federal do Maranhão - HU-UFMA, São Luís, MA, Brasil.

Uterine inversion is an uncommon complication of the puerperium and it is an even rarer complication of the non-puerperal period. In this way, uterine inversions are classified into two groups, being of puerperal origin due to obstetric problems and non-puerperal origin due to gynecological problems. In general, a non-puerperal uterine inversion occurs as a possible complication of a sub mucosal leiomyoma, after an expansive process, a dilation of the cervix occurs and thus its protuberance over the vaginal canal. Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.130DOI Listing
February 2019
2 Reads

Ectopic leiomyoma as a late complication of laparoscopic hysterectomy with power morcellation: a case report and review of the literature.

Acta Chir Belg 2019 Mar 20:1-5. Epub 2019 Mar 20.

a Department of Surgery , AZ Zeno , Knokke-Heist , Belgium.

Introduction: Electromechanical power morcellation is a widely used technique to extract uterine fibroids during laparoscopic hysterectomy. Although the complication rate of morcellators is low, ectopic leiomyoma can appear several years after their use.

Patients And Methods: We present a case of an ectopic leiomyoma and a literature review of power morcellation-induced complications and ectopic leiomyoma. Read More

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http://dx.doi.org/10.1080/00015458.2019.1586396DOI Listing
March 2019
1 Read

MR imaging of paratesticular bilateral leiomyoma: A case report.

Radiol Case Rep 2019 May 7;14(5):591-594. Epub 2019 Mar 7.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy.

Paratesticular leiomyoma is a rare benign neoplasm that may arise from smooth muscle cells contained in either the epididymis, the spermatic cord, or the tunica albuginea. Usually patients present a palpable, asymptomatic mass, with a higher prevalence among the fourth and fifth decade of life. In this case report we describe a 57-year-old man with bilateral scrotal palpable masses evaluated with ultrasound and magnetic resonance imaging that were suggestive for leiomyoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407094PMC

Nasopharyngeal Leiomyoma.

Ear Nose Throat J 2019 Feb 13;98(2):74-75. Epub 2019 Feb 13.

1 Department of Otolaryngology-Head and Neck Surgery, State University of New York at Buffalo, Buffalo, NY, USA.

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http://dx.doi.org/10.1177/0145561318824503DOI Listing
February 2019
1 Read

Clinical analysis of hepatic angioleiomyoma: Two case reports.

Medicine (Baltimore) 2019 Mar;98(11):e14661

Department of Hepatobiliary and Pancreatic Surgery.

Rationale: Angioleiomyoma is an uncommon benign tumor that originates from the vascular smooth muscle cells and contains thick-walled vessels. It can appear anywhere in the body but more frequently in the extremities (especially in the lower limbs) and rarely invades the internal organs.

Patient Concerns: A 52-year-old Chinese woman was referred to our hospital because of finding liver neoplasm 2 weeks ago (case first) and a 64-year-old Chinese woman was admitted to hospital with enlargement of the hepatic neoplasm revealed in follow-up, who was diagnosed with angioleiomyoma of left kidney 2 years ago (case second). Read More

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http://dx.doi.org/10.1097/MD.0000000000014661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426533PMC
March 2019
1 Read

Resection of Mucosal and Submucosal Gastrointestinal Lesions and a Double Endoscope Experience.

JSLS 2019 Jan-Mar;23(1)

Istanbul Training and Research Hospital, Department of General Surgery, Fatih, Istanbul, Turkey.

Aim: The patients who underwent endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for mucosal and submucosal lesions of the esophagus, stomach, and duodenum and the advantages of the double endoscope method we used for traction during ESD were evaluated.

Material And Methods: The patients who underwent ESD and EMR due to upper gastrointestinal lesions were evaluated retrospectively between January 2014 and April 2018 in our endoscopy unit.

Result: The mean age of 10 patients with esophageal lesions was 53 years. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408942PMC
March 2019
1 Read

A rare case of paratesticular leiomyoma in a child.

Turk J Urol 2018 Sep 12;45(2):154-156. Epub 2018 Sep 12.

Department of Radiology, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey.

Leiomyomas are benign, slow-growing, smooth muscle tumors, which can occur at many locations in the body. The male genitourinary tract is seldom affected and scrotal leiomyomas are extremely rare. Most of the scrotal leiomyomas are localized in the testis, epididymis, spermatic cord, subcutaneous tissue, tunica albuginea, and scrotal skin and only a few of them are reported in the origin of isolated tissue without paratesticular structures in the paratesticular region. Read More

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http://turkishjournalofurology.com/eng/makale/3457/180/Full-
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http://dx.doi.org/10.5152/tud.2018.28813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368035PMC
September 2018
8 Reads

Ulipristal acetate decreases active TGF-β3 and its canonical signaling in uterine leiomyoma via two novel mechanisms.

Fertil Steril 2019 Apr 11;111(4):806-815.e1. Epub 2019 Mar 11.

Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address:

Objective: To characterize the effect of ulipristal acetate (UPA) treatment on transforming growth factor (TGF) canonical and noncanonical signaling pathways in uterine leiomyoma tissue and cells. UPA decreased extracellular matrix in surgical specimens; we characterize the mechanism in this study.

Design: Laboratory study. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.12.026DOI Listing
April 2019
1 Read
4.590 Impact Factor

Uterine artery occlusion at myomectomy.

Fertil Steril 2019 Mar 11. Epub 2019 Mar 11.

Department of Obstetrics and Gynecology, Mount Sinai Hospital and Women's College Hospital, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To demonstrate three approaches to uterine artery occlusion at time of myomectomy as a blood-sparing intraoperative technique.

Design: A step-by-step explanation of the procedure with surgical video footage.

Setting: Academic medical center. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282193005
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http://dx.doi.org/10.1016/j.fertnstert.2019.01.019DOI Listing
March 2019
9 Reads

Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials.

Hum Reprod 2019 Apr;34(4):623-634

AbbVie Inc., North Chicago, IL, USA.

Study Question: Can asoprisnil, a selective progesterone receptor modulator, provide clinically meaningful improvements in heavy menstrual bleeding (HMB) associated with uterine fibroids with an acceptable safety profile?

Summary Answer: Uninterrupted treatment with asoprisnil for 12 months effectively controlled HMB and reduced fibroid and uterine volume with few adverse events.

What Is Known Already: In a 3-month study, asoprisnil (5, 10 and 25 mg) suppressed uterine bleeding, reduced fibroid and uterine volume, and improved hematological parameters in a dose-dependent manner.

Study Design, Size, Duration: In two Phase 3, double-blind, randomized, placebo-controlled, multicentre studies, women received oral asoprisnil 10 mg, asoprisnil 25 mg or placebo (2:2:1) once daily for up to 12 months. Read More

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http://dx.doi.org/10.1093/humrep/dez007DOI Listing
April 2019
2 Reads

Unique case of 'trigger wrist' secondary to deep tissue leiomyoma in a healthy 6-year-old.

ANZ J Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Orthopaedic Surgery, Women's and Children's Hospital, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/ans.15062DOI Listing
March 2019
8 Reads

Painful tumors of the skin: "CALM HOG FLED PEN AND GETS BACK".

Clin Cosmet Investig Dermatol 2019 13;12:123-132. Epub 2019 Feb 13.

Compass Dermatopathology, San Diego, CA, USA.

Painful tumors of the skin present as dermal or subcutaneous nodules. They can originate from several sources: adipose tissue, cartilage degeneration, deposition of bone or calcium, eccrine glands, fibrous tissue, infiltration of benign (endometrium) or malignant (metastatic neoplasm) tissue, muscle, nerve, or vascular structures. Although pathologic evaluation of the lesion is necessary to determine the diagnosis, it is possible to make a reasonable differential diagnosis based on knowledge of prior tumors that have appeared as tender lesions. Read More

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https://www.dovepress.com/painful-tumors-of-the-skin-calm-ho
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http://dx.doi.org/10.2147/CCID.S193359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386355PMC
February 2019
6 Reads

Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids.

Medicine (Baltimore) 2019 Mar;98(10):e14566

Department of Medical Imaging, The First Affiliated Hospital, Kunming Medical University, Kunming.

The aim of the present study was to investigate factors affecting ablation effect and safety of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids (UFs).A retrospective analysis of 346 patients with symptomatic UFs who were treated with USgHIFU was performed. All UFs was grouped based on magnetic resonance imaging (MRI) characteristics before HIFU; all adverse events and treatment data were recorded during and after HIFU. Read More

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http://dx.doi.org/10.1097/MD.0000000000014566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417526PMC
March 2019
1 Read
5.723 Impact Factor

Intravascular (post-hysterectomy) leiomyoma (IVL) as late tumor thrombus within the inferior vena cava (IVC)-A rare case primarily imposing as IVC thrombus originating from left renal vein after former left nephrectomy status.

Pathol Res Pract 2019 Feb 28. Epub 2019 Feb 28.

Division of Vascular Surgery, Dept. of General, Abdominal, Vascular and Transplant Surgery, University Hospital, Otto-von-Guericke University at Magdeburg, Germany. Electronic address:

Introduction: Intravascular leiomyoma is a rare type of myoma. It was firstly described by Birch-Hirschfeld in 1896, however, its intracardiac subtype was firstly reported by Durck in 1907. Most patients are asymptomatic. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.009DOI Listing
February 2019
3 Reads

Preoperative Differentiation of Uterine Sarcoma from Leiomyoma: Comparison of Three Models Based on Different Segmentation Volumes Using Radiomics.

Mol Imaging Biol 2019 Mar 8. Epub 2019 Mar 8.

Department of Radiology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing, 100034, China.

Purpose: To investigate the impact of applying three different volume of interests (VOIs) in ADC map-based radiomic analysis and compare their diagnostic performance in the differentiation of uterine sarcoma and atypical leiomyoma.

Procedures: Seventy-eight patients (29 uterine sarcomas, 49 uterine leiomyomas) imaged with pelvic magnetic resonance imaging (MRI) prior to surgery were included in this retrospective study. Manually, segmentations of VOIs covered three different regions on apparent diffusion coefficient (ADC) maps: (1) tumor, (2) tumor and small piece of surrounded tissue, and (3) whole uterus. Read More

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http://dx.doi.org/10.1007/s11307-019-01332-7DOI Listing
March 2019
2 Reads

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.

Int J Mol Sci 2019 Mar 6;20(5). Epub 2019 Mar 6.

Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Uterine leiomyomas (LMs), currently the most common gynecological complaint around the world, are a serious medical, social and economic problem. Accurate diagnosis is the necessary prerequisite of the diagnostic-therapeutic process. Statistically, mistakes may occur more often in case of disease entities with high prevalence rates. Read More

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http://dx.doi.org/10.3390/ijms20051136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429074PMC
March 2019
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New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System.

Med Sci Monit Basic Res 2019 Mar 7;25:76-87. Epub 2019 Mar 7.

Endocannabinoid Research Group, Reproductive Sciences, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom.

BACKGROUND The aim of this study was to determine if components of the endocannabinoid system are modulated in uterine leiomyomas (fibroids). Components studied included cannabinoid receptors 1 (CB1) and 2 (CB2); the G protein-coupled receptor GPR55; transient potential vanilloid receptor 1 (TRPV1) and the endocannabinoid modulating enzymes N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), and their N-acylethanolamine (NAE) ligands: N-arachidonylethanolamine (AEA), N-oleoylethanolamine (OEA), and N-palmityolethanaolamine (PEA). MATERIAL AND METHODS Transcript levels of CB1, CB2, TRPV1, GPR55, NAPE-PLD, and FAAH were measured using RT-PCR and correlated with the tissue levels of the 3 NAEs in myometrial tissues. Read More

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http://dx.doi.org/10.12659/MSMBR.914019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421936PMC
March 2019
2 Reads

The Autonomic Innervation and Uterine Telocyte Interplay in Leiomyoma Formation.

Cell Transplant 2019 Mar 6:963689719833303. Epub 2019 Mar 6.

1 Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.

The autonomic innervation of the uterus is involved in multiple pathophysiological processes in both humans and animals. Pathological conditions such as adenomyosis or inflammatory pelvic disease are usually accompanied by significant alterations in uterine innervation. In the current study, we focused on autonomic innervation of uterine fibroids, the identification of recently described interstitial cells, telocytes, and the possible interplay between these structures. Read More

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http://dx.doi.org/10.1177/0963689719833303DOI Listing
March 2019
5 Reads
3.570 Impact Factor

Role of general gynaecologists in the prevention of infertility.

Authors:
Ertan Saridogan

Best Pract Res Clin Obstet Gynaecol 2019 Feb 6. Epub 2019 Feb 6.

Consultant in Reproductive Medicine and Minimal Access Surgery, University College London Hospitals, UK. Electronic address:

Gynaecologists are frequently involved in the management of conditions that may result in reduced fertility or treatments they administer can lead to infertility. Sexually transmitted infections and pelvic inflammatory disease are the most common cause of tubal damage. Gynaecologists can play an important role in the identification and early treatment of these diseases. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.014DOI Listing
February 2019
8 Reads

Uterine Artery Embolization in Patients With Autoimmune Disease: A Matched Case-Control Study.

AJR Am J Roentgenol 2019 Mar 5:1-6. Epub 2019 Mar 5.

1 Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro Seodaemun-gu, Seoul 03722, Korea.

Objective: The purpose of this study is to investigate the safety of uterine artery embolization (UAE) for symptomatic leiomyomas in patients with autoimmune disease.

Materials And Methods: Of 1183 patients who underwent UAE for symptomatic leiomyomas, nine patients (mean age, 42.6 years; range, 34-49 years) with autoimmune disease were included in this study. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20432
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http://dx.doi.org/10.2214/AJR.18.20432DOI Listing
March 2019
7 Reads

EWSR1-PBX3 gene fusion in cutaneous syncytial myoepithelioma.

J Cutan Pathol 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

Cutaneous syncytial myoepithelioma (CSM) is a recently recognized, histopathological variant of myoepithelial (ME) tumors of the skin. It is characterized by a syncytial arrangement of spindled, ovoid, and/or epithelioid cells forming a well-circumscribed, unencapsulated dermal nodule. There is a paucity of intervening stroma, and absent duct or gland formation. Read More

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http://dx.doi.org/10.1111/cup.13450DOI Listing

Heterotopic pancreas involved muscularis propria mimicking mesenchymal tumor in stomach.

J Surg Case Rep 2019 Feb 25;2019(2):rjz045. Epub 2019 Feb 25.

Division of General Surgery, Cathay General Hospital, Taipei City, Taiwan (ROC).

Heterotopic pancreas is defined as pancreatic tissue found outside the usual anatomic location of the pancreas. It is often an incidental finding and can be found at various sites in the gastrointestinal tract. It is usually asymptomatic, however, symptoms such as abdominal pain, nausea, vomiting or even gastrointestinal bleeding could be possible. Read More

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http://dx.doi.org/10.1093/jscr/rjz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388082PMC
February 2019
6 Reads

Magnetic Resonance and Intraoperative Imaging of a Periurethral Leiomyoma.

J Minim Invasive Gynecol 2019 Feb 28. Epub 2019 Feb 28.

Departments of Urology (Drs. Sussman Tano, and Brucker).

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http://dx.doi.org/10.1016/j.jmig.2019.02.013DOI Listing
February 2019
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Cystic lung lesions mimicking hydatidosis: hamartoma or benign metastazing leiomyoma?

Ann Thorac Surg 2019 Feb 27. Epub 2019 Feb 27.

Department of Pathology, Strasbourg University Hospital, 1 Place de l'Hopital, 67000, Strasbourg, France.

We report an unusual case of a 53-year-old woman who presented with multiple lung cystic lesions presumed to be related to pulmonary hydatidosis, treated and followed for 3 years before surgical removal was decided. Unexpectedly, pathological findings showed the presence of benign spindle cell proliferation. Immunohistochemical staining confirmed the smooth muscle nature of the spindle cells which were also positive for hormonal receptors and corresponded to multiple cystic pulmonary hamartomas. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.044DOI Listing
February 2019
3 Reads

Spontaneous reduction of an incarcerated gravid uterus after myomectomy in the second trimester: A case report.

Medicine (Baltimore) 2019 Mar;98(9):e14731

Obstetrics and Gynecology Department of The Third Hospital of Peking University, Haidian District, Beijing, China.

Rationale: During a normal pregnancy, in the 1st trimester uterus lies in pelvis and enlarges in size as the pregnancy advances. By 14 weeks of gestation, the gravid uterus transforms from a pelvis to an abdominal organ and a retroverted uterus will correct as the fundus rises out of the pelvis and falls forward to its normal anatomical position. If the uterus remains in the pelvic cavity after 14 weeks of gestation, it is referred to as an incarcerated uterus. Read More

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http://dx.doi.org/10.1097/MD.0000000000014731DOI Listing
March 2019
2 Reads
5.723 Impact Factor