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Vet Radiol Ultrasound 2021 May 14. Epub 2021 May 14.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

Diagnosis of gastric tumors in dogs is difficult and is often obtained by biopsy following identification of a mass through ultrasound (US) or endoscopy. In human medicine, modalities such as CT and endoscopy are standard of care in the diagnosis and staging of gastric tumors. Although one veterinary study has described CT findings of gastric tumors in dogs using iatrogenic gas dilation, there are no veterinary studies that have directly compared the usefulness of US versus CT in the diagnosis and staging of these tumors. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211014690

Howard University Hospital, Washington, DC, USA.

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a sexual developmental disorder. In this disorder, there is a congenital absence of the uterus and vagina with normal external genitalia. The etiology is not well understood. Read More

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Obstetrics and Gynecology, Seoul Medical Center, Jungnang-gu, Seoul, Republic of Korea.

Acute appendicitis is the most common nonobstetric condition requiring surgery in pregnancy. However, the diagnosis of acute appendicitis during pregnancy is challenging because of obscure clinical manifestations and laboratory findings. Intravenous antibiotic treatment is not preferred over operation because of the poor outcome. Read More

Fertil Steril 2021 May 8. Epub 2021 May 8.

First Department of Obstetrics and Gynecology, Papageorgiou University Hospital, Aristotle University of Thessaloniki Thessaloniki, Greece.

Objective: To demonstrate a systematic approach for the hysteroscopic management of a patient with uterine septum with double cervix and a nonobstructive longitudinal vaginal septum (Class U2bC2V1 of the ESHRE/ESGE classification).

Design: A step-by-step demonstration of the technique with narrated video footage of three different cases.

Setting: University Hospital. Read More

World J Surg Oncol 2021 May 8;19(1):144. Epub 2021 May 8.

Department of Surgery, University of Michigan School of Medicine, 1500 E. Medical Center Drive, Ann Arbor, Michigan, 48109-5932, USA.

Background: Lipoleiomyoma is a rare, benign variant of the commonplace uterine leiomyoma. Unlike leiomyoma, these tumors are composed of smooth muscle cells admixed with mature adipose tissue. While rare, they are most frequently identified in the uterus, but even more infrequently have been described in extrauterine locations. Read More

Georgian Med News 2021 Mar(312):119-125

Tbilisi State Medical University, Georgia.

Uterine leiomyomas decrease the quality of life by causing significant morbidity among women of reproductive age. Histologically various types of leiomyoma's can be differentiated. We have analysed the histopathological, proliferation, apoptotic and hormonal profile in different types of leiomyomas. Read More

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Department of Oral & Maxillofacial Pathology and Microbiology, Amrita Vishwa Vidyapeetham, Amrita School of Dentistry, Kochi, Kerala, India.

Myofibromas are benign neoplasms of myofibroblastic origin and rarely encountered in the oral cavity. Myofibroma may frequently grow rapidly leading to suspicion of malignancy. This may lead to a tendency for aggressive management. Read More

Reprod Biol Endocrinol 2021 May 5;19(1):67. Epub 2021 May 5.

Department of Gynecology, Federal University of Piauí, Rua Doutor Anisio Maia, 1261, Ininga, Piauí, 64049-810, Teresina, Brazil.

Background: Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, including intense bleeding, compression of adjacent organs, pain, and infertility. Some studies show that vitamin D receptor (VDR) expression is correlated with the etiology of uterine leiomyomas. Read More

Rev Esp Enferm Dig 2021 May 5. Epub 2021 May 5.

Digestive Medicine, Hospital Clínico Universitario de Valencia.

Surgery has been considered the main treatment for submucosal tumors (SMTs); however, endoscopic resection is currently accepted for gastric SMTs smaller than 3cm. Endoscopic submucosal dissection (ESD) is considered the technique of choice and submucosal tunneling endoscopic resection shows successful results with low complication rate in the recent meta-analysis by Cao et al. The major limitation of these methods is the technical difficulty to be applied in certain anatomic locations. Read More

J Menopausal Med 2021 Apr;27(1):42-45

Department of Obstetrics and Gynecology, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea.

Uterine fibroid, or leiomyoma, is a common benign neoplasm in women, but serious complications are rarely reported. We present the case of a 48-year-old woman with acute onset of abdominal pain. She was hemodynamically unstable, and computed tomography revealed abundant fluid collection in the peritoneal cavity, suggesting hemoperitoneum. Read More

J Menopausal Med 2021 Apr;27(1):37-41

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Uterine leiomyoma is a very common gynecological tumor in the reproductive years. Recent studies have shown that surgical treatment of uterine leiomyoma using robotic-assisted laparoscopic myomectomy (RALM) is associated with significantly fewer complications, lower estimated blood loss, fewer conversions, and less bleeding than conventional laparoscopic myomectomy. This study reports the case of a giant uterine leiomyoma treated using RALM. Read More

J Obstet Gynaecol 2021 May 3:1-5. Epub 2021 May 3.

Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey.

The current study aimed to analyse and compare the vascularity of FIGO Type 4-7 leiomyoma specimens obtained from women with or without abnormal uterine bleeding (AUB). The records of 31 women who underwent myomectomy for FIGO Type 4-7 leiomyomas in a university hospital setting were analysed. Group I ( = 16) was composed of women that were symptomatic for AUB and group II ( = 15) consisted of asymptomatic cases. Read More

Sci Rep 2021 Apr 30;11(1):9371. Epub 2021 Apr 30.

Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.

Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC (n = 16; FH-mutation confirmed) and non-syndromic (NS) patients (n = 12) identified a significantly higher protein:transcript correlation in HLRCC (R = 0.35) vs. Read More

Cytotechnology 2021 Apr 4;73(2):179-187. Epub 2021 Feb 4.

Five Departments of Recuperation in Dalian Rehabilitation and Recuperation Center, No.30, Binhai West Road, Xigang District, Dalian City, 116013 Liaoning province China.

The study intends to investigate the regulation of syndecan-1 in human uterine leiomyoma cells. Human syndecan-1 levels were detected by Western blot in uterus leimyoma's tissue. The efficacy of syndecan-1 silencing on the cell proliferation, metalloproteinases and extracellular matrix were determined through Cell Counting Kit (CCK8) assay and Western blot assay, respectively. Read More

BMC Surg 2021 Apr 29;21(1):221. Epub 2021 Apr 29.

Department of Anesthesiology, Shahid Beheshti Hospital, Yasuj University of Medical Sciences, Yasuj, Iran.

Background: Squamous cell carcinoma is the most common epithelial tumor of the esophagus. Upper endoscopy with multiple minimally invasive biopsies should be performed to confirm the diagnosis. Leiomyoma of esophagus is rare, but it's the most common benign submucosal mesenchymal tumor of the esophagus. Read More

Diagnostics (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.

Objective: The assessment of the usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) when qualifying patients with uterine fibroids (UFs) for magnetic resonance-guided high-intensity ultrasound (MR-HIFU).

Material And Methods: This retrospective, single center study included 283 women who underwent DCE-MRI and were treated with MR-HIFU. The patients were divided according to non-perfused volume (NPV) as well as by the type of curve for patients with a washout curve in the DCE-MRI study and patients without a washout curve. Read More

Dermatopathology (Basel) 2021 Apr 15;8(2):103-106. Epub 2021 Apr 15.

Dermatopathologie Friedrichshafen, 88048 Friedrichshafen, Germany.

Smooth muscle hamartoma are usually solitary and congenital, may affect the genital area and nipples. Histopathologically, they are characterized by the presence of mature smooth muscle bundles. We present a 40 year-old male with bilateral nipple enlargement excised with clinical suspicion of bilateral leiomyoma. Read More

Cancers (Basel) 2021 Apr 8;13(8). Epub 2021 Apr 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Hereditary retinoblastoma survivors have substantially increased risk of subsequent malignant neoplasms (SMNs). The risk of benign neoplasms, a substantial cause of morbidity, is unclear. We calculated the cumulative incidence of developing benign tumors at 60 years following retinoblastoma diagnosis among 1128 hereditary (i. Read More

Tex Heart Inst J 2021 Jan;48(1)

Harrington Heart & Vascular Institute, Cardiovascular Medicine Department, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

We report a rare case of benign metastasizing leiomyoma in the heart of a 45-year-old woman 2 years after a uterine leiomyoma had been discovered during hysterectomy. Computed tomograms at presentation showed a large mixed cystic mass in the pelvis and bilateral lung nodules suggestive of metastatic disease. A large cardiac mass, attached to the chordae of the tricuspid valve and later shown to be histopathologically consistent with uterine leiomyoma, was successfully resected through a right atriotomy. Read More

Ginekol Pol 2021 Apr 30. Epub 2021 Apr 30.

Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Warsaw, Poland.

Objectives: Uterine fibroids (UF) are the most common benign tumors of the female reproductive organ. It is crucial to recognize that the appropriate treatment of UFs requires an individualized approach. The present paper aimed at the presentation of the five-year experience of our center in the treatment of UFs with the use of magnetic resonance-guided high-intensity ultrasound (MR-HIFU) therapy. Read More

Reprod Sci 2021 Apr 29. Epub 2021 Apr 29.

Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Research, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 624, Baltimore, MD, 21205, USA.

Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however, collagenase had not been evaluated in vivo for effects on uterine fibroids. The objective was to assess the safety and tolerability of collagenase injection directly into uterine fibroids. Read More

Int J Appl Basic Med Res 2021 Apr-Jun;11(2):108-110. Epub 2021 Apr 8.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

A giant uterine fibroid is a rare tumor of the uterus. Uterine leiomyomas are the most common type of a benign tumor that arises from the female pelvis. Uterine leiomyoma is a smooth muscle tumor. Read More

Reprod Sci 2021 Apr 27. Epub 2021 Apr 27.

Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.

In recent years, significant advancements have been made in the way the complex proteome samples are compared but the ultimate goal of routine biomarker discovery has yet to be achieved. Based on reverse genetic strategy, our study involved the spotting of genes showing expressional variability in uterine leiomyoma females. Serum samples were taken from uterine leiomyomas subjects (n=6) and healthy control subjects (n=6) for proteomic studies. Read More

Reprod Biomed Online 2021 Mar 23. Epub 2021 Mar 23.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via M. Fanti, 6, Milan 20122, Italy.

Available evidence from IVF studies supports a detrimental effect of submucosal and intramural fibroids on embryo implantation. It is misleading, however, to infer evidence obtained in IVF settings to natural fertility. Therefore, a systematic review and meta-analysis was conducted on the effect of fibroids on natural fertility. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Apr 26;49(2):134-141. Epub 2021 Apr 26.

Klinische Abteilung für Kleintierchirurgie, Universitätsklinik für Kleintiere, Department für Kleintiere und Pferde, Vetmeduni Wien.

An 8-year-old female spayed dog was presented due to simultaneous inability to defecate and urinate. During digital rectal examination a smooth, rounded, firm-elastic mass was detected. Laboratory results showed a 6-fold elevation of serum lactate dehydrogenase activity. Read More

Am J Case Rep 2021 Apr 26;22:e931051. Epub 2021 Apr 26.

Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Medical Faculty, Universitas Airlangga, Surabaya, Indonesia.

BACKGROUND No standard guidelines have been specified for a cesarean myomectomy, and several centers remain divided on the justification to perform this procedure, especially for large fibroids. Only a few case reports have been published of cesarean myomectomy for large fibroids. Here, we report 2 cases of successful cesarean myomectomies for large fibroids (>15 cm) during the 38th week of pregnancy. Read More

J Med Case Rep 2021 Apr 24;15(1):193. Epub 2021 Apr 24.

Department of Obstetric and Gynecology, Adesh institute of Medical Sciences and Research, Bathinda, Punjab, India.

Background: Routine myomectomy at the time of cesarean section has been condemned in the past due to fear of uncontrolled hemorrhage and peripartum hysterectomy. It is still a topic of debate worldwide. However, in recent years, many case studies of cesarean myomectomy have been published validating its safety without any significant complications. Read More

Childs Nerv Syst 2021 Apr 22. Epub 2021 Apr 22.

Pediatric Neurosurgery Department, Dr. Asenjo Neurosurgical Institute, Santiago, Chile.

Primary intracranial smooth muscle tumors are rare. Most cases are related to Epstein-Barr virus proliferation in immunocompromised patients such as organ solid recipients. Only a few cases have been reported in pediatric patients. Read More

Cureus 2021 Apr 14;13(4):r29. Epub 2021 Apr 14.

Gynaecological Oncology, Guy's and St Thomas' Nhs Foundation Trust, London, GBR.

[This retracts the article DOI: 10.7759/cureus.7168. Read More

Reprod Sci 2021 Apr 20. Epub 2021 Apr 20.

Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, BJC Institute of Health - 10th Floor, RM 10606, 425 S. Euclid Avenue, Campus Box 8064, St. Louis, MO, 63110, USA.

Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. Read More