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J Clin Med 2022 May 7;11(9). Epub 2022 May 7.

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.

The main symptoms of adenomyosis may adversely affect physical and mental health and quality of life (QOL). However, studies are few on this topic. This study evaluated the effect of adenomyosis on anxiety, depression, and QOL. Read More

Cancers (Basel) 2022 May 7;14(9). Epub 2022 May 7.

Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via Filippo Corridoni, 16, 60123 Ancona, Italy.

: This study aimed to systematically review the existing literature on uterine smooth muscle tumor of uncertain malignant potential (STUMP) to provide information about characteristics and outcomes of patients and the risk factors for recurrence over a period of 60 years (1960-2021). According to PRISMA guidelines, we searched for "uterine smooth muscle tumor of uncertain malignant potential" in PubMed (all fields) and Scopus (Title/Abstract/Keywords) databases (accessed on 1 January 2022). Relevant articles were obtained in full-text format and screened for additional references. Read More

F S Sci 2021 Aug 13;2(3):303-314. Epub 2021 Apr 13.

Department of Gynecology and Obstetrics, Division of Reproductive Sciences and Women's Health Research, Johns Hopkins Medicine, Baltimore, Maryland.

Objective: To determine if A-kinase anchoring protein 13 (AKAP13) interacts with the vitamin D receptor (VDR) to alter vitamin D-dependent signaling in fibroid cells. Uterine leiomyomas (fibroids) are characterized by a fibrotic extracellular matrix and are associated with vitamin D deficiency. Treatment with vitamin D (1,25-dihydroxyvitamin D) reduces fibroid growth and extracellular matrix gene expression. Read More

F S Sci 2021 Nov 26;2(4):407-418. Epub 2021 Oct 26.

Department of Experimental and Clinical Medicine, Faculty of Medicine, Università Politecnica delle Marche, Ancona, Italy. Electronic address:

Objective: To screen 14 different plant extracts for their antifibrotic effect on human primary leiomyoma and healthy myometrial cells.

Design: Preclinical study.

Setting: University research laboratory. Read More

F S Sci 2021 Nov 5;2(4):396-406. Epub 2021 Aug 5.

Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address:

Objective: To assess and characterize the role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in the development of uterine leiomyoma.

Design: Laboratory study.

Setting: Academic research center. Read More

F S Sci 2021 May 6;2(2):219-227. Epub 2020 Oct 6.

Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Program in Reproductive Endocrinology and Gynecology, National Institutes of Health, Bethesda, Maryland. Electronic address:

Objective: To characterize the method by which angiogenesis occurred in three-dimensional (3D) leiomyoma xenografts, and to assess the impact of hypoxia on two-dimensional (2D) and 3D myometrial and leiomyoma cells and leiomyoma xenografts in vivo.

Design: Laboratory study.

Setting: Academic research. Read More

Front Cardiovasc Med 2022 26;9:871983. Epub 2022 Apr 26.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Intravenous leiomyomatosis (IVL) is a distinct uterine leiomyoma, even rare when combined with intracardiac invasion. Although leiomyomas are histologically benign, intracardiac metastasis may cause circulatory failure and death. Herein, we report a 55-year-old woman with a tricuspid chordae mass on echocardiography. Read More

Abdom Radiol (NY) 2022 May 13. Epub 2022 May 13.

Division of Diagnostic Imaging, Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Houston, Texas, 77030, USA.

Uterine fibroids are the most common gynecologic neoplasm. Although non-degenerated fibroids are easily identifiable on imaging, degenerated fibroids, fibroid variants, and fibroids with unusual growth patterns can constitute a diagnostic dilemma. Identification of these abnormal morphologic features can alter the diagnosis of presumed uterine fibroids and hence change management plans. Read More

Case Rep Obstet Gynecol 2022 2;2022:7931391. Epub 2022 May 2.

Crispi Institute of Minimally Invasive Surgery, Rio de Janeiro, RJ, Brazil.

A 36-year-old Caucasian, nulliparous patient sought care at a private gynecology clinic after 6 months of attempting to conceive. During the initial consultation, the patient reported severe dysmenorrhea and deep dyspareunia. During the gynecological examination, a nodule in the left lateral vaginal fornix was palpable. Read More

Eye (Lond) 2022 May 10. Epub 2022 May 10.

Liverpool Ocular Oncology Centre, Liverpool University Hospitals Trust, Liverpool, UK.

Spinal Cord Ser Cases 2022 May 9;8(1):51. Epub 2022 May 9.

Northwest Regional Spinal Injuries Centre, District General Hospital, Southport, PR8 6PN, UK.

Introduction: Chronic irritation caused by urinary catheter may predispose to metaplastic changes in the bladder and very rarely, nephrogenic metaplasia.

Case Presentation: A 53-year-old lady with T-2 paraplegia and urethral catheter drainage for 27 years presented with haematuria. MRI of pelvis, performed seven years ago, showed a 10 cm intramural fibroid within the anterior aspect of the uterine body which was pushing the collapsed urinary bladder containing the Foley catheter to the left. Read More

Front Oncol 2022 11;12:876277. Epub 2022 Apr 11.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: Esophageal leiomyoma is the most common benign tumor in the esophagus. Thoracotomy and thoracoscopy are both elective for esophageal leiomyoma enucleation. This study aimed at presenting surgical experience in our center and exploring more suitable surgical methods for different situations. Read More

Front Surg 2022 19;9:875484. Epub 2022 Apr 19.

Department of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Background: The analgesic effect produced by the intra-arterial injection of lidocaine in patients undergoing uterine artery embolization has been proven to be safe and effective. Nevertheless, a significant degree of pain is typically experienced after the operation, and pain management is crucial. Methylprednisolone, which provides an anti-inflammatory effect, is widely used in the treatment of several diseases. Read More

Fertil Steril 2022 May;117(5):1094-1095

Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California.

Front Surg 2022 18;9:842707. Epub 2022 Apr 18.

Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, China.

Benign metastatic leiomyoma (BML) is a histologically benign disease with invasive biological behavior. Most patients are women of childbearing age with a history of uterine leiomyoma. The progress of the disease is relatively slow, the prognosis is good, and most patients can survive for a long time. Read More

Surg Case Rep 2022 May 5;8(1):84. Epub 2022 May 5.

Department of Thoracic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease that can occur in women with a history of uterine leiomyoma. Despite its benign histological features, like a malignancy, leiomyomas can on rare occasion spread to the lung. Typically, PBML presents with asymptomatic multiple solid lung nodules with slow tumor progression, following hysterectomy. Read More

BMC Pregnancy Childbirth 2022 May 3;22(1):387. Epub 2022 May 3.

Department of Obstetrics and Gynecology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Background: To evaluate pregnancy outcomes and the risk of adverse obstetrical outcomes of cesarean myomectomy (CM) compared with cesarean section (CS) only, and to investigate the trend of surgeons in choosing CM.

Methods: A retrospective cohort study was performed on all patients who underwent CS complicated by leiomyoma at two university hospitals between January 2010 and May 2020. All patients were categorized into the CM (341 women) or CS-only (438 women) group. Read More

J Gastroenterol Hepatol 2022 May 2. Epub 2022 May 2.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background And Aim: The small endoscopic ultrasound (EUS)-suspected gastric gastrointestinal stromal tumors (GISTs), gastric subepithelial tumors at the muscularis propria layer on EUS, are detected frequently. Bite-on-bite forceps biopsy and EUS-guided tissue sampling yield variable results. This study aimed to analyze clinicopathologic features of the small EUS-suspected gastric GISTs 2 cm or less in size and to evaluate the efficacy and safety of the endoscopic incisional biopsy (EIB) for these small tumors. Read More

J Gynecol Surg 2022 Apr 1;38(2):143-147. Epub 2022 Apr 1.

MedStar Washington Hospital Center, Washington, District of Columbia, USA.

Objective: To determine quality-adjusted life years (QALYs) over 3 years after transcervical fibroid ablation (TFA) with the Sonata System.

Methods: The SONATA trial was a prospective multicenter interventional trial that assessed the safety and efficacy of TFA for treatment of women with symptomatic uterine fibroids. Change in generic health status was assessed with the EuroQol 5-Dimension questionnaire (0-1 scale). Read More

Cureus 2022 Mar 25;14(3):e23473. Epub 2022 Mar 25.

Internal Medicine, Raritan Bay Medical Center, Perth Amboy, USA.

Parasitic leiomyomas (PL) are rare cause of small bowel obstruction (SBO) in young women. Usually, they arise in women who underwent laparoscopic or surgical morcellation of uterine fibroids. PL may present with vague abdominal pain, constipation, obstipation, or rarely SBO. Read More

J Vasc Surg Cases Innov Tech 2022 Jun 14;8(2):240-243. Epub 2022 Mar 14.

Department of Surgery, Henry Ford Macomb Hospital, Clinton Township, MI.

In the present report, we describe the case of a young woman with a large uterine leiomyoma causing phlegmasia cerulea dolens with thrombosis of the left common and left external iliac veins. She underwent tissue plasminogen activator catheter thrombolysis and mechanical thrombectomy to temporize the condition until she could be evaluated by a gynecologic oncologist to remove the cause of the venous obstruction. Before the hysterectomy, a suprarenal inferior vena cava filter was placed. Read More

J Minim Invasive Gynecol 2022 Apr 28. Epub 2022 Apr 28.

Division of Minimally Invasive Gynecological Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.. Electronic address:

Study Objective: To demonstrate tips and tricks for the successful use of single site laparoscopic surgery (SILS) for pedunculated myomectomy during pregnancy.

Design: Stepwise demonstration with narrated video footage SETTING: An academic tertiary care hospital affiliated with Baylor College of Medicine. Our patient is a 39-year-old pregnant G1P0 with a symptomatic 12 centimeter degenerating pedunculated fibroid refractory to conservative pain management. Read More

Adv Ther 2022 Apr 30. Epub 2022 Apr 30.

Obstetrics and Gynecology, Division of Clinical Genetics, Feinberg School of Medicine of Northwestern University, Chicago, USA.

Iron deficiency (ID), with or without anemia, is commonly found worldwide and affects the health and wellbeing of pregnant and nonpregnant women. Symptoms of ID- which include fatigue, pica (ice craving), restless legs syndrome, poor concentration and work function, increased susceptibility to infection, and cardiovascular stress- can cause significant morbidity and reduced quality of life. The etiologies of iron deficiency in women are usually specific to each community. Read More

Zhonghua Fu Chan Ke Za Zhi 2022 Apr;57(4):244-252

Department of Obstetrics and Gynecology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

To compare the long-term outcomes after focused ultrasound ablation surgery (FUAS) versus myomectomy for uterine fibroids. A retrospective study was conducted on women who were treated by FUAS or myomectomy for uterine fibroids at First Medical Center of Chinese PLA General Hospital from January 2007 to January 2015. Regular follow-up was conducted to evaluate the symptoms relief, symptoms recurrence, the need for re-interventions and complications of the two groups. Read More

Indian J Nucl Med 2022 Jan-Mar;37(1):68-70. Epub 2022 Mar 25.

Department of Nuclear Medicine and Molecular Imaging, Homi Bhabha National Institute, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Benign metastasizing leiomyoma is a rare condition where benign smooth muscle tumors having a histological appearance similar to uterine leiomyoma are present at distant sites. This entity is commonly associated with a past history of hysterectomy done for uterine fibroids. The knowledge of the presence of significant fluorodeoxyglucose uptake in leiomyoma helped in the diagnosis of this condition in a 47-year-old patient who being evaluated for multiple unusual sites of metastases; this was further confirmed on histopathology. Read More

BMC Womens Health 2022 Apr 27;22(1):139. Epub 2022 Apr 27.

Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan.

Background: Bet1 Golgi vesicular membrane trafficking protein-like (BET1L) rs2280543 single nucleotide polymorphism (SNP) and diet have been independently associated with uterine leiomyoma (UL). However, whether the SNP and diet could jointly influence the risk of UL is yet to be assessed. Therefore, we investigated the independent and interactive effects of vegetarian diet and BET1L rs2280543 on uterine fibroids in Taiwanese women. Read More

Medicine (Baltimore) 2022 Apr 15;101(15):e29181. Epub 2022 Apr 15.

Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Rationale: Tracheal bronchus is an aberrant bronchus that arises directly from the carina of the trachea. It was rare, with only 0.1% to 2% on the right and 0. Read More

J Pathol 2022 Apr 26. Epub 2022 Apr 26.

Fundación IVI, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

Uterine leiomyomas are the most common benign tumors in women of reproductive age. Despite the high prevalence, tumor pathology remains unclear, which hampers development of safe and effective treatments. Epigenetic mechanisms appear to be involved in uterine leiomyoma development, particularly via DNA methylation that regulates gene expression. Read More

Am Soc Clin Oncol Educ Book 2022 Apr;42:1-10

Sylvester Comprehensive Center Cancer/University of Miami Miller School of Medicine, Miami, FL.

Uterine sarcomas are rare mesenchymal tumors that are aggressive cancers. The rarity of these tumors, and consequently limited prospective data, has made surgical management of uterine sarcomas challenging. One major obstacle in the management of uterine sarcomas is establishing the diagnosis prior to surgery, which is crucial for appropriate intraoperative management. Read More

Oxf Med Case Reports 2022 Apr 19;2022(4):omac036. Epub 2022 Apr 19.

Department of Gynecology and Obstetrics, Military Hospital of Instruction Mohamed V Rabat, Rabat, Morocco.