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    High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
    Histopathology 2017 Aug 18. Epub 2017 Aug 18.
    Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, No.20, Yuhuangding East Road, Yantai, 264000, China.
    High molecular weight caldesmon (H-caldesmon) is the protein that binds to actin and tropomyosin regulating smooth muscle contraction function.(1) It is mainly expressed in smooth muscle cells and the research data showed the specificity of smooth muscle is higher than that of desmin and actin.(2) In clinical diagnosis, H-caldesmon can be used to identify myofibroblastic tumors from true leiomyoma and to differentiate uterine smooth muscle tumors from endometrial stromal sarcoma combined with CD10. Read More

    Literature Review on the Role of Uterine Fibroids in Endometrial Function.
    Reprod Sci 2017 Jan 1:1933719117725827. Epub 2017 Jan 1.
    1 Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    Uterine fibroids are benign uterine smooth muscle tumors that are present in up to 8 out of 10 women by the age of 50. Many of these women experience symptoms such as heavy and irregular menstrual bleeding, early pregnancy loss, and infertility. Traditionally believed to be inert masses, fibroids are now known to influence endometrial function at the molecular level. Read More

    Successful Myomectomy during Cesarean Section: Case Report & Literature Review.
    Int J Biomed Sci 2017 Jun;13(2):119-121
    Gynecologist & Obstetrician, Mehr General Hospital, Tehran, Iran.
    Myomectomy is the most common surgery with cesarean section. There is controversy between obstetricians about doing myomectomy with cesarean section. A 29 years old primigravida patient presented with a large lower segment myoma (20 cm. Read More

    Inguinal canal spermatic cord leiomyoma presenting as an incarcerated inguinal hernia.
    BMJ Case Rep 2017 Aug 17;2017. Epub 2017 Aug 17.
    HPB Surgery, Cleveland Clinic, Cleveland, Ohio, USA.
    Leiomyoma is a benign neoplasm originating from smooth muscle cells and is most commonly seen in the uterus, followed by the small bowel and oesophagus. We report a rare case of a 41-year-old male patient with a spermatic cord leiomyoma that presented as an inguinal canal mass mimicking an irreducible inguinal hernia without scrotal involvement. This report highlights the rare presentation and workup of an inguinal mass, importance of intraoperative decision making based on operative findings and the significance of postoperative pathology findings. Read More

    Non-Surgical Management of Myomas.
    J Minim Invasive Gynecol 2017 Aug 15. Epub 2017 Aug 15.
    Associate Professor, Departments of Obstetrics and Gynecology and Surgery, Mayo Clinic Rochester, MN, USA, 200 1st Street SW, Rochester MN 55905. Electronic address:
    Uterine myomas are a common condition and the leading cause of hysterectomy. Clinically, myomas can be challenging because they range from being asymptomatic to causing severe, debilitating symptoms and occur in many women before child-bearing is complete. Thus, women often seek uterine- conserving and non-surgical management of their myomas. Read More

    Intraosseous Leiomyoma of the Jaw in an Adolescent.
    J Dent Child (Chic) 2017 May;84(2):90-96
    Chief, in the Department of Oral and Maxillofacial Surgery, Hospital Universitari de Bellvitge, in Barcelona, Spain.
    Leiomyoma is a benign tumor of the smooth muscle that rarely occurs in the mouth as an intraosseous lesion. The purposes of this paper are to: (1) present a case of an intraosseous solid leiomyoma of the mandible in a 13-year-old child, who presented with a well-defined unilocular radiolucency in the right mandible incidentally discovered during a routine dental radiographic examination; and (2) conduct a review of the literature to describe clinicopathological features and management of intraosseous jaw leiomyoma (IJL). A total of 17 articles describing 18 cases of IJL satisfied the selection criteria; including the present patient, to date a total of 19 cases of IJL have been reported. Read More

    High clinical impact and diagnostic accuracy of EUS-guided biopsy sampling of subepithelial lesions: a prospective, comparative study.
    Surg Endosc 2017 Aug 15. Epub 2017 Aug 15.
    Division of Medical Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 3, 413 45, Gothenburg, Sweden.
    Background: In a tertiary center setting we aimed to study the diagnostic accuracy and clinical impact of EUS-guided biopsy sampling (EUS-FNB) with a reverse bevel needle compared with that of fine needle aspiration (EUS-FNA) in the work-up of subepithelial lesions (SEL).

    Methods: All patients presenting with SELs referred for EUS-guided sampling were prospectively included in 2012-2015. After randomization of the first pass modality, dual sampling with both EUS-FNB and EUS-FNA was performed in each lesion. Read More

    Unique Learning System for Uterine Artery Embolization for Symptomatic Myoma and Adenomyosis for Obstetrician- Gynecologists in Cooperation with Interventional Radiologists: Evaluation of UAE From the Point of View of Gynecologists Who Perform UAE.
    J Minim Invasive Gynecol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Obstetrics and Gynecology.
    Study Objective: To evaluate a unique learning system for uterine artery embolization (UAE), and its feasibility and clinical outcomes for symptomatic uterine leiomyoma and adenomyosis performed by obstetrician- gynecologists in cooperation with interventional radiologists.

    Design: Retrospective study (Canadian Task Force classification II-2).

    Setting: University hospital. Read More

    Efficacy of PET/CT to exclude leiomyoma in patients with lesions suspicious for uterine sarcoma on MRI.
    Taiwan J Obstet Gynecol 2017 Aug;56(4):508-513
    Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Hongo 2-1-1, Bunkyo-ku, 113-8431, Japan. Electronic address:
    Objective: To analyze the efficacy of positron emission tomography/computed tomography (PET/CT) for the diagnosis of uterine sarcoma.

    Materials And Methods: Thirty-four patients evaluated between January 2010 and March 2015 were retrospectively enrolled. All patients in whom uterine sarcoma was suspected based on contrast-enhanced magnetic resonance imaging (MRI) findings (heterogeneous, high signal intensity on T2-weighted images and/or high intensity on T1-weighted images) underwent PET/CT for further assessment. Read More

    Obstructive mobile small intestinal tumor without radiographic stigmata of bezoar.
    Int J Surg Case Rep 2017 Jul 19;39:36-38. Epub 2017 Jul 19.
    Division of General Surgery, Department of Surgery, SBH Health System, 4422 Third Avenue, Bronx, NY, 10457 USA; New York College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568 USA. Electronic address:
    Introduction: Gastrointestinal leiomyomas are often clinically silent until they bleed or grow large enough to cause local mass effect.

    Presentation Of Case: We report the unique case of an otherwise healthy 69-year-old male who developed a small bowel obstruction secondary to a mobile small intestinal leiomyoma. During initial evaluation, computed tomography did not demonstrate the cause of obstruction. Read More

    Transvaginal postpartum manual removal of a prolapsed submucous leiomyoma, initially diagnosed hybrid predominantly intramural.
    BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.
    Department of Obstetrics & Gynaecology, Sidra Medical & Research Centre, Doha, Qatar.
    We present a rare case of a large infarcted submucous fibroid removed manually after a normal vaginal delivery. This patient was known to have a large postero-fundal hybrid predominantly intramural uterine fibroid, measuring 11 x 10 cm in diameter and diagnosed 2 years prior to last conception. Thirty-five days postpartum, she presented with severe lower abdominal pain and foul smell per vaginum. Read More

    Massive ascites, pelvic mass, elevated CA-125 and weight loss: think outside the 'ovaries'.
    BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.
    Department of Obstetrics and Gynaecology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
    A 44-year-old woman presented with 3 months' history of painless progressive abdominal distension and weight loss of more than 15 kg. Clinically a pelviabdominal mass with ascites was detected. CT scan of the pelvis and abdomen showed a subserosal leiomyoma with huge amount of ascites. Read More

    [Expression and significance of IKKε in the specimens and cells of epithelial ovarian cancer].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jul;52(7):483-489
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
    Objective: To examine the expressions of IKKε protein in the specimens and cells of epithelial ovarian cancer and investigate the effect of IKKε inhibitor on cell proliferation and apoptosis. Methods: (1) A total of 118 cases of patients with the median age of 59 who have accepted surgical treatment due to ovarian cancer in the First Affiliated Hospital of Dalian Medical University from January 2006 to April 2013 were selected. Twenty cases of patients with the median age of 55 who have accepted hysterectomy and salpingo-oophorectomy due to uterine leiomyoma during the same period were selected as the control. Read More

    [Validation of the Chinese version of the uterine fibroid symptom and health-related quality of life].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jul;52(7):455-460
    Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 102218, China.
    Objective: To evaluate the reliability and validity of the Chinese version of the uterine fibroid symptom and health-related quality of life (UFS-QOL) in patients with uterine fibroid. Methods: The original English UFS-QOL was translated into Chinese and linguistically validated following the cross-cultural adaptation of health-related quality of life measures. Patients recruited randomly from Peking Union Medical College Hospital from June 2013 to December 2016 were scheduled for two visits with 2 weeks apart, and they were surveyed through the Chinese version of UFS-QOL and short-form 12-item health survey (SF-12). Read More

    A randomized control trial to assess efficacy of Mifepristone in medical management of uterine fibroid.
    Med J Armed Forces India 2017 Jul 7;73(3):267-273. Epub 2017 Apr 7.
    Classified Specialist (Obst & Gynae), Base Hospital, Delhi Cantt, India.
    Background: Fibroids are the most common benign tumours of uterus. Heavy menstrual bleeding is the commonest concern for which medical attention is sought. Hysterectomies for leiomyoma constitute a third of all hysterectomies. Read More

    Cotyledonoid Dissecting Leiomyoma with Symplastic Features: Case Report.
    Rev Bras Ginecol Obstet 2017 Aug 7;39(8):436-440. Epub 2017 Aug 7.
    Department of Gynecology and Obstetrics, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
    Purpose Cotyledonoid dissecting leiomyoma is a leiomyoma variant exhibiting unusual growth patterns. We aimed to demonstrate this, as well as to point out another feature that has not been previously reported. Case Report A congested, multinodular myomectomy specimen was resected. Read More

    Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report.
    Rev Bras Ginecol Obstet 2017 Aug 7;39(8):433-435. Epub 2017 Aug 7.
    Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
    Genital leiomyomas are rare tumors that can often be misdiagnosed as Bartholin cyst. We report a case of a 32-year-old patient who had a cystic nodulation in the left labium majus that was suggestive of Bartholin cyst. A resection surgery was performed, and the definitive histopathology diagnosis was vulvar leiomyoma. Read More

    Uterine Artery Doppler Velocimetry of Uterine Leiomyomas in Nigerian Women.
    Rev Bras Ginecol Obstet 2017 Aug 7. Epub 2017 Aug 7.
    Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
    Objective To describe the blood flow velocities and impedance indices changes in the uterine arteries of leiomyomatous uteri using Doppler sonography. Methods This was a prospective, case-control study conducted on 140 premenopausal women with sonographic diagnosis of uterine leiomyoma and 140 premenopausal controls without leiomyomas. Pelvic sonography was performed to diagnose and characterize the leiomyomas. Read More

    Subepithelial esophageal tumors: a single-center review of resected and surveilled lesions.
    Gastrointest Endosc 2017 Aug 3. Epub 2017 Aug 3.
    Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester MN. Electronic address:
    Background And Aims: Subepithelial esophageal tumors (SETs) are frequent incidental findings. Although symptomatic tumors are surgically or endoscopically resected, there is no consensus on the management of asymptomatic esophageal leiomyomas.

    Methods: Appropriate ICD-9 codes followed by medical record review were used to identify patients with SETs from January 1992 to March 2017, with abstraction of basic demographics, surveillance intervals, and mortality. Read More

    Non-neural granular cell tumor of the uterine corpus mimicking uterine leiomyoma: A case report.
    Mol Clin Oncol 2017 Sep 13;7(3):351-354. Epub 2017 Jul 13.
    Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Hashimoto, Wakayama 648-0005, Japan.
    Non-neural granular cell tumors (GCTs) are clinically rare, whereas cases arising in the uterine corpus are exceedingly rare. Only three uterine cervical cases of GCTs have been reported to date and, to the best of our knowledge, there are no reports of GCT of the uterine corpus in the literature. We herein describe the first case of non-neural GCT arising from the uterine corpus reported to date. Read More

    3D power Doppler in uterine fibroids; influence of gain, cardiac cycle and off-line measurement techniques.
    J Obstet Gynaecol 2017 Aug 7:1-7. Epub 2017 Aug 7.
    a Department of Obstetrics and Gynaecology , VU University Medical Centre , Amsterdam , The Netherlands.
    This study answers the question of whether ultrasound machine settings and the cardiac cycle can influence 3D power Doppler (3D PD) indices in the evaluation of uterine fibroid vascularisation. These parameters were reported to affect the vascular indices and cause undesired variation. 3D PD ultrasound was performed using three different gain settings: a fixed predetermined gain (50 dB), a higher gain (65 dB) and an individualised subjectively most optimal gain. Read More

    Role of 3-Dimensional Sonography in the Assessment of Submucous Fibroids: A Pilot Study.
    J Ultrasound Med 2017 Aug 4. Epub 2017 Aug 4.
    Department of Obstetrics and Gynecology, VU Medical Center, Amsterdam, Netherlands.
    Objectives: To investigate the accuracy and reliability of 3-dimensional (3D) transvaginal sonography in classifying submucous fibroids using the International Federation of Gynecology and Obstetrics PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, and not yet classified) classification and protrusion (percent) compared to 2-dimensional (2D) transvaginal sonography, 2D saline infusion sonography, and 3D saline infusion sonography, using hysteroscopy as a reference test.

    Methods: A prospective cohort pilot study was performed among 14 consecutive patients undergoing hysteroscopic surgery, preceded by routine sonography (2D transvaginal sonography, 2D saline infusion sonography, 3D transvaginal sonography, and 3D saline infusion sonography).

    Results: The intraclass correlation coefficient (ICC) for 2D transvaginal sonography versus hysteroscopy was 0. Read More

    Acute GI bleed due to leiomyoma of the jejunum: a case report.
    J Surg Case Rep 2017 Jul 28;2017(7):rjx138. Epub 2017 Jul 28.
    Department of General Surgery, Grandview Medical Center, Dayton, OH 45405, USA.
    Neoplasms of the small intestine are rare. Leiomyomas are the one of the benign neoplasms that can be found in the small intestine. These lesions usually remain asymptomatic and are often found incidentally; however, they can become symptomatic if obstruction occurs or the tumor outgrows its blood supply resulting mucosa. Read More

    Combining situ-morcellation with continuous-fill-mattress suture in laparoscopic myomectomy: A surgical approach of choice for patients with large uterine fibroids.
    Medicine (Baltimore) 2017 Aug;96(31):e7672
    Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
    Background: To investigate the efficacy and advantage of combining situ-morcellation with continuous-fill-mattress suture compared with conventional morcellation and suture in laparoscopic myomectomy.

    Methods: One hundred sixteen patients who underwent laparoscopic myomectomy from March 2014 to October 2016.

    Interventions: Patients were divided into combining situ-morcellation with continuous-fill-mattress suture group (n = 62) and conventional group (n = 54), and subsequent statistical analysis the clinical data of the 2 groups. Read More

    Imaging Features of Rare Mesenychmal Liver Tumors: Beyond Hemangiomas.
    Br J Radiol 2017 Aug 2:20170373. Epub 2017 Aug 2.
    1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Tumors arising from mesenchymal tissue components such as vascular, fibrous and adipose tissue can manifest in the liver. Although histopathology is often necessary for definitive diagnosis, many of these lesions exhibit characteristic imaging features. The radiologist plays an important role in suggesting the diagnosis, which can direct appropriate immunohistochemical staining at histology. Read More

    Microscopic tubal sex cord proliferations with a Sertoli cell tumour pattern and ovarian-type stromal transformation of the fimbriae.
    Histopathology 2017 Jul 30. Epub 2017 Jul 30.
    Departments of Pathology at University of Granada, Spain.
    A recent paper(1) reported microscopic nodules of sex-cord stromal proliferations mimicking adult granulosa cell and sex-cord tumour with annular tubules in extraovarian locations. However, Sertoli cell tumour patterns were not described in them. We add two cases of multiple, microscopic foci of differentiated Sertoli cell proliferation in the fallopian tube, one of which coexisted and merged with areas of fimbrial ectopic ovarian-like stroma. Read More

    CT and MR Imaging of Gynecologic Emergencies.
    Radiographics 2017 Jul 28:160170. Epub 2017 Jul 28.
    From the Department of Radiology (Y.I., M.O., R.I., K.A., T.Y., M.T., S.M.) and Department of Obstetrics and Gynecology (Y.A.), Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.
    Gynecologic emergencies include various diseases that result from adnexal and uterine disorders. Adnexal disorders may be classified into the following three categories: (a) disorders that cause hemorrhage (hemorrhagic ovarian cysts and ectopic pregnancies); (b) disorders related to adnexal tumors (adnexal torsion and rupture of ovarian tumors); and (c) disorders related to pelvic inflammatory disease, such as tubo-ovarian abscesses. Unusual adnexal torsion, such as massive ovarian edema, isolated fallopian tube torsion, and paraovarian cyst torsion, has also been described. Read More

    Myofibroblastic, fibroblastic and myoid lesions of the breast.
    Semin Diagn Pathol 2017 May 28. Epub 2017 May 28.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
    Myofibroblastic, fibroblastic and/or myoid lesions are rare in the breast but comprise the majority of mammary mesenchymal spindle cell lesions. Whereas most have similar features to their counterparts at extramammary sites, pseudoangiomatous stromal hyperplasia is considered a breast-specific myofibroblastic proliferation on the same spectrum as myofibroblastoma. Other lesions with myofibroblastic/fibroblastic differentiation include fibromatosis and nodular fasciitis, as well as more aggressive tumors such as the rarely reported myofibrosarcoma, inflammatory myofibroblastic tumor and fibrosarcoma. Read More

    Primary intracranial leiomyoma in renal transplant recipient.
    Saudi J Kidney Dis Transpl 2017 Jul-Aug;28(4):921-924
    Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.
    Leiomyoma, the benign tumor of smooth muscle cell origin, is commonly seen in genitourinary and gastrointestinal tracts. Primary intracranial leiomyoma, however, is extremely rare occurrence. We hereby report a case of Epstein-Barr negative primary intracranial leiomyoma in a middle-aged renal transplant recipient, which mimicked left frontal parasagittal meningioma on neuroimaging. Read More

    Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report.
    BMC Cancer 2017 Jul 26;17(1):503. Epub 2017 Jul 26.
    Service of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, E-, 28041, Madrid, Spain.
    Background: Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on optimal management strategies.

    Case Presentation: A 60-year-old woman with a history of an asymptomatic uterine leiomyoma presented in October 2015 with postmenopausal bleeding and a friable vaginal cyst that bled when palpated. Read More

    Prevalence of undiagnosed uterine leiomyosarcoma in women undergoing hysterectomy or myomectomy for benign indications.
    Eur J Obstet Gynecol Reprod Biol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland. Electronic address:
    Objective: To determine the prevalence of undiagnosed uterine leiomyosarcoma (LMS) in women undergoing hysterectomy or myomectomy for suspected benign leiomyomas.

    Study Design: Retrospective, single-centre, cohort study. Information for all gynaecological procedures for suspected benign leiomyomas between 1993 and 2016 was extracted from the hospital database. Read More

    A Rare Case of Intramural Müllerian Adenosarcoma Arising from Adenomyosis of the Uterus.
    J Pathol Transl Med 2017 Jul 29;51(4):433-440. Epub 2017 Jun 29.
    Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea.
    Müllerian adenosarcomas usually arise as polypoid masses in the endometrium of post-menopausal women. Occasionally, these tumors arise in the cervix, vagina, broad and round ligaments, ovaries and rarely in extragenital sites; these cases are generally associated with endometriosis. We experienced a rare case of extraendometrial, intramural adenosarcoma arising in a patient with adenomyosis. Read More

    Comment on "Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation".
    Reprod Biol Endocrinol 2017 Jul 20;15(1):54. Epub 2017 Jul 20.
    Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Department of Obstetrics and Gynecology, Vito Fazzi Hospital, Piazza Muratore, Lecce, Italy.
    Background: The cause of contamination and dissemination of leiomyoma tissue particles and cells in the peritoneal cavity during myomectomy is a challenging issue for both clinicians and researchers. Therefore, the article by Huang et al. recently published in your journal is the subject of this letter. Read More

    Laparoscopic Intragastric Surgery With Endoscopic Assistance: A 2 Gastrostomy Approach With Multiple Applications.
    Surg Laparosc Endosc Percutan Tech 2017 Jul 20. Epub 2017 Jul 20.
    *Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY †Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX.
    Purpose: Laparoscopic intragastric resection is a surgical modality with acceptable oncologic outcomes for gastrointestinal stromal tumors and leiomyomas, particularly for masses located near the gastroesophageal junction (GEJ). We describe our technique of 2 gastrostomy laparoscopic, intragastric resection with endoscopic assistance.

    Methods: We detail our technique and report a unique application of this versatile approach. Read More

    Inflammatory Myofibroblastic Tumors of the Female Genital Tract Are Under-recognized: A Low Threshold for ALK Immunohistochemistry Is Required.
    Am J Surg Pathol 2017 Jul 20. Epub 2017 Jul 20.
    *Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research ¶Gynaecological Oncology, Royal North Shore Hospital, St Leonards †Department of Anatomical Pathology, Royal North Shore Hospital ∥University of Sydney #Department of Obstetrics and Gynecology, St George Hospital **University of NSW ‡‡Prince of Wales Clinical School, University of New South Wales, Sydney ††Department of Medical Oncology, Prince of Wales Hospital and Royal Hospital for Women, Randwick ‡Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital §The Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
    Inflammatory myofibroblastic tumor (IMT) of the female genital tract is under-recognized. We investigated the prevalence of ALK-positive IMT in lesions previously diagnosed as gynecologic smooth muscle tumors. Immunohistochemistry (IHC) for ALK was performed on tissue microarrays of unselected tumors resected from 2009 to 2013. Read More

    Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.
    Mod Pathol 2017 Jul 21. Epub 2017 Jul 21.
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Gastroblastoma is a rare distinctive biphasic tumor of the stomach. The molecular biology of gastroblastoma has not been studied, and no affirmative diagnostic markers have been developed. We retrieved two gastroblastomas from the consultation practices of the authors and performed transcriptome sequencing on formalin-fixed paraffin-embedded tissue. Read More

    Spontaneous pregnancy during ulipristal acetate treatment of giant uterine leiomyoma.
    J Clin Pharm Ther 2017 Jul 21. Epub 2017 Jul 21.
    "Sveti Duh" University Hospital, Zagreb, Croatia.
    What Is Known And Objective: Ulipristal acetate, a progesterone receptor modulator, pharmacologically inhibits endometrial proliferation and thereby prevents pregnancy. It is primarily used as emergency contraception, but also for the treatment of fibroids in women of reproductive age. There have been no published cases of pregnancy, while on therapy with ulipristal acetate. Read More

    Novel perspectives on gastrointestinal stromal tumors (GISTs).
    Rom J Morphol Embryol 2017 ;58(2):339-350
    Department of Pathology, "Colentina" Clinical Hospital, Bucharest, Romania;
    Since they were described, gastrointestinal stromal tumors (GISTs) are, for pathologists and not only for them, a subject of controversy regarding histological origin, differentiation, nomenclature, malignant potential and prognosis. Before 1998, there were no certainties that GISTs were fundamentally different from other types of abdominal cancers in the big family of mesenchymal tumors. Before the discovery of KIT gene mutations, GISTs were most often classified as leiomyoma, leiomyosarcoma, leiomyoblastoma, and gastrointestinal autonomic nerve tumor. Read More

    A Multicentre Retrospective Review of Clinical Characteristics of Uterine Sarcoma.
    J Obstet Gynaecol Can 2017 Aug;39(8):652-658
    Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON. Electronic address:
    Objective: Professional societies have recently urged gynaecologists to counsel patients about the risks of encountering uterine sarcoma at fibroid surgery especially when morcellation is used. Our objective was to learn the preoperative and postoperative characteristics of patients with uterine sarcoma to better counsel patients undergoing surgery for presumably benign fibroids.

    Methods: This is a multicentre, retrospective cohort study. Read More

    Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review.
    J Nippon Med Sch 2017 ;84(3):139-143
    Department of Obstetrics and Gynecology, Nippon Medical School.
    Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Read More

    Perioperative management of intracardiac leiomyomatosis: An observational cohort study.
    Medicine (Baltimore) 2017 Jul;96(29):e7522
    aDepartment of Anesthesiology bDepartment of Cardiac Surgery, Chinese Academy of Medical Sciences/Peking Union Medical College Hospital cDepartment of Anesthesiology, Peking University International Hospital, Beijing, P.R. China.
    Intracardiac leiomyomatosis (ICLM) is a rare condition in which the benign tumor extends into the right heart chambers through inferior vena cava. The best surgical approach still remains unclear.We present a retrospective cohort of 36 patients diagnosed with ICLM in Peking Union Medical College Hospital between 2002 and 2016. Read More

    [Evaluation of a new closure technique of large defects after endoscopic full-thickness resection].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Jul;20(7):775-781
    Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Objective: To investigate the security and efficacy of a new endoscopic closure method of large defects after endoscopic full-thickness resection (EFTR) double purse-string suture using two endoloops and metallic clips via single-channel endoscopy.

    Methods: Clinical data of 23 cases with submucosal tumors (SMT) who received endoscopic resection from June 2015 to July 2016 in our National Cancer Center were collected. For gastric and esophageal SMTs or the mucosa layer injured during submucosal tunneling endoscopic resection (STER), double purse-string suture was conducted after EFTR. Read More

    Uterine Lipoleiomyoma: A Report of Two Cases.
    J Clin Imaging Sci 2017 28;7:26. Epub 2017 Jun 28.
    Department of Radiodiagnosis, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
    We report two cases of uterine lipoleiomyoma in postmenopausal women of ages 52 and 55 years, who presented with complaints of leukorrhea and lower abdominal pain, respectively. Lipoleiomyoma is a rare benign variant of leiomyoma, having an incidence of 0.03%-0. Read More

    African genetic ancestry interacts with body mass index to modify risk for uterine fibroids.
    PLoS Genet 2017 Jul 17;13(7):e1006871. Epub 2017 Jul 17.
    Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Race, specifically African ancestry, and obesity are important risk factors for uterine fibroids, and likely interact to provide the right conditions for fibroid growth. However, existing studies largely focus on the main-effects rather than their interaction. Here, we firstly provide evidence for interaction between categories of body mass index (BMI) and reported-race in relation to uterine fibroids. Read More

    Clinical limitations of the International Federation of Gynecology and Obstetrics (FIGO) classification of uterine fibroids.
    Int J Gynaecol Obstet 2017 Jul 17. Epub 2017 Jul 17.
    Department of Surgery, Mayo Clinic, Rochester, MN, USA.
    Objective: To determine the reproducibility of classifying uterine fibroids using the 2011 International Federation of Gynecology and Obstetrics (FIGO) staging system.

    Methods: The present retrospective cohort study included patients presenting for the treatment of symptomatic uterine fibroids at the Gynecology Fibroid Clinic at Mayo Clinic, Rochester, USA, between April 1, 2013 and April 1, 2014. Magnetic resonance imaging of fibroid uteri was performed and the images were independently reviewed by two academic gynecologists and two radiologists specializing in fibroid care. Read More

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