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Int J Surg Case Rep 2020 May 29;71:327-330. Epub 2020 May 29.

Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1 Aoyama, Kure City, Hiroshima, 737-0023, Japan; Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Introduction: We experienced an extremely rare case of gastric adenocarcinoma wrapped by leiomyoma.

Presentation Of Case: A 65-year-old man had an abnormality (filling defect) of the upper gastrointestinal series in his first medical checkup five years prior. Esophagogastroduodenoscopy detected a 10 mm submucosal tumor-like lesion in the greater curvature of the upper gastric remnant body. Read More

J Gynecol Obstet Hum Reprod 2020 May 31:101822. Epub 2020 May 31.

Department of Obstetrics and Gynecology, Del Ponte Hospital, University of Insubria, Varese, Italy.

Aim: Vaginal paraurethral leiomyomas are uncommon benign tumors of the female genitourinary tract. We report a case of anterior vaginal paraurethral leiomyoma. Furthermore, we performed a systematic review of the literature to provide information that can help the physicians in the diagnosis and management of women with this rare pathology. Read More

Physiol Int 2020 Mar;107(1):106-119

2Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.

Purpose: We aimed to assess the etiological role of apoptotic genes Bcl-2 and Bax in the background of major obstetric and gynaecological diseases.

Methods: Placental tissue samples were collected from 101 pregnancies with intrauterine growth restriction and 104 pregnancies with premature birth with 140 controll samples from term, eutrophic newborns. In addition, gene expression assessment of the genes Bax and Bcl-2 was performed in 101 uterine leiomyoma tissue samples at our disposal with 110 control cases. Read More

Ultrasound Obstet Gynecol 2020 Jun 2. Epub 2020 Jun 2.

Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.

Objective: To describe the ultrasound features of different endometrial and other intracavitary pathologies in pre- and postmenopausal women presenting with abnormal uterine bleeding using the International Endometrial Tumor Analysis (IETA) terminology.

Methods: Prospective observational multicenter study of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced ultrasonography with color Doppler was performed in all cases and fluid instillation sonography in 1857. Read More

Medicine (Baltimore) 2020 May;99(22):e20196

Department of Physical and Rehabilitation Medicine.

Introduction: Leiomyoma of peripheral nerve is a rare condition characterized by neuropathy of affected nerve. We herein report a rare presentation of leiomyoma of radial nerve which presented with wrist drop.

Patient Concerns: A 37-year-old man visited our clinic with a history of sudden onset weakness of the wrist dorsiflexion/finger extension of the right side. Read More

Int J Surg Case Rep 2020 May 23;71:217-221. Epub 2020 May 23.

Urology Department, Sahloul Hospital, Sousse, Tunisia.

Introduction: Leiomyomas are benign tumors that originate from smooth muscles cells. Intratesticular leiomyoma is a very rare type of benign testicular masses. Through the literature, only 11 cases were reported. Read More

Front Oncol 2020 14;10:647. Epub 2020 May 14.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The term "uterine smooth muscle tumor of uncertain malignant potential" (STUMP) indicates a rare tumor that cannot be classified as a benign leiomyoma or malignant leiomyosarcoma. In this study, we assessed the clinical characteristics, fertility, and oncologic outcomes of patients diagnosed as STUMP in 14 years. In addition, we analyzed the risk factors for recurrence in patients with STUMP. Read More

Esophagus 2020 May 30. Epub 2020 May 30.

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Esophageal squamous cell carcinoma (ESCC) and leiomyoma are common tumors. The coexistence of these two tumors can be classified into two types: the overlying type and the separate type. The overlying type is rare. Read More

Am J Obstet Gynecol 2020 May 28. Epub 2020 May 28.

Johns Hopkins School of Medicine, Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Research. Electronic address:

Objective: Despite the high prevalence of uterine fibroids, the psychosocial impact of fibroids has not been evaluated across different quality of life indicators and compared to other chronic conditions. Here we rigorously analyzed available evidence pertaining to the psychosocial burden of uterine fibroids in premenopausal women and compare validated quality of life and symptom scores before and after treatment.

Data Sources: We searched PubMed, PsycINFO, ClinicalTrials. Read More

J Obstet Gynaecol Can 2020 Mar 12. Epub 2020 Mar 12.

Department of Obstetrics & Gynecology, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.

J Vasc Surg Venous Lymphat Disord 2020 May 25. Epub 2020 May 25.

Divison of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China. Postal Code: 510080. Electronic address:

Objective: This study aimed to summarize our experience with the diagnosis and treatment of intravenous leiomyomatosis (IVL) involving the inferior vena cava (IVC) or right cardiac chambers.

Methods: This study retrospectively analyzed clinical data from 10 patients diagnosed with IVL involving the IVC or right cardiac chambers between May 2009 and October 2019 at one medical center.

Results: All patients were females aged 35 to 56 years (average, 46. Read More

Radiol Case Rep 2020 Jul 20;15(7):1066-1070. Epub 2020 May 20.

Consultant Radiologist, Head of Department, Nanavati super-speciality Hospital, Mumbai, India.

Primary ovarian leiomyoma is a very rare benign mesenchymal tumor arising from the smooth muscle of walls of ovarian blood vessels. It is usually seen between 20 65 years of age. Being asymptomatic in many patients, these are incidentally detected. Read More

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology, University Hospital of Saint-Etienne, France.

Objectives: Uterine lesions with plexiform morphology are uncommon lesions with debated histogenesis. Despite being an incidental and usually benign finding (plexiform tumorlet), some cases can pose diagnostic problems. Their paucity in the recent literature adds to these difficulties and often causes ambiguities. Read More

Pathologe 2020 May 26. Epub 2020 May 26.

Pathologisches Institut, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland.

The nipple-areola complex is the origin of various morphologically distinct tumors and tumor-like lesions, which can be delineated from the special structures of the nipple, in particular the intramammary ducts, skin-appendages, and the intramammary stroma. Benign tumors are most frequent and this includes epithelial tumors such as mammary adenoma and syringomatous tumor of the nipple. Less commonly observed are benign mesenchymal tumors such as leiomyoma of the nipple, or tumor-like lesions like pseudo-lymphoma. Read More

Placenta 2020 Apr 26;95:44-52. Epub 2020 Apr 26.

Makassed General Hospital, Beirut, Lebanon.

Placenta accreta spectrum (PAS) is a major obstetrical problem whose incidence is rising. Current guidelines recommend screening of all women with placenta previa and risk factors for PAS between 20 and 24 weeks. Risk factors, diagnosis, and management of previa PAS are well established, but an apparently normal location of the placenta does not exclude PAS. Read More

J Obstet Gynaecol Res 2020 May 25. Epub 2020 May 25.

Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

A tumor metastasis within another tumor is known as tumor-to-tumor metastasis (TTM). We report a 43-year-old woman who presented with hypermenorrhea and an abdominal mass. She had history of a soft tissue tumor on her left ankle at 38 years of age. Read More

World Neurosurg 2020 May 22. Epub 2020 May 22.

Department of Neurosurgery, University of Illinois at Chicago.

J Minim Invasive Gynecol 2020 May 22. Epub 2020 May 22.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital (Linkou) and Chang Gung University College of Medicine, Taoyuan (Drs. Pai and Yen). Electronic address:

Mol Hum Reprod 2020 May 25. Epub 2020 May 25.

Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, VIC.

Current treatment options for uterine fibroids are limited to hormonal manipulation or surgical intervention. We aimed to develop an in-vitro model to mirror collagen deposition and extracellular matrix (ECM) formation, the principal features of uterine fibroids, to enable testing of novel therapeutics. Macromolecular crowding with Ficoll 400 and Ficoll 70 in cultures of human uterine myometrial smooth muscle cells containing ascorbic acid, provided the basis for this model. Read More

Ultrasound Med Biol 2020 May 21. Epub 2020 May 21.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, Republic of China. Electronic address:

The aim of this study was to assess the imaging features of urethral and peri-urethral masses on transvaginal or transperineal ultrasound (US) in a cohort of 95 women. In this retrospective study, medical records of 95 female patients with 98 asymptomatic or symptomatic urethral and peri-urethral masses were retrospectively reviewed. Data regarding patient demographic characteristics, symptoms, signs, imaging features on 2-D and 3-D transvaginal or transperineal US, diagnostic tests and physical and intra-operative findings were extracted. Read More

BMC Ophthalmol 2020 May 24;20(1):198. Epub 2020 May 24.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Posterior choroidal leiomyoma is an extremely rare tumor, to our knowledge, less than 10 cases reported in the literature. The definite diagnosis can be confirmed by immunohistochemistry, and local resection is preferable to enucleation for the posterior choroidal leiomyoma.

Case Presentation: Two adult Asian women presented with progressive vision loss in their right eyes. Read More

Clin Imaging 2020 May 3;66:23-25. Epub 2020 May 3.

Dotter Department of Interventional Radiology, Oregon Health & Science University, Portland, OR, USA. Electronic address:

A 50-year-old female with a 20-year history of multifocal pulmonary benign metastasizing leiomyoma (BML), and asthma presented with subacute worsening of chronic dyspnea. A contrast-enhanced computerized tomography of the chest showed a single 1.4 × 1. Read More

Urology 2020 May 10. Epub 2020 May 10.

Scott and White Medical Center.

BMC Womens Health 2020 May 20;20(1):110. Epub 2020 May 20.

Department of Obstetrics and Gynaecology, Geneva University Hospitals, 30 Bld de la Cluse, 1211, Geneva, Switzerland.

An amendment to this paper has been published and can be accessed via the original article. Read More

N Engl J Med 2020 05;382(21):2066

SUNY Downstate Health Sciences University, Brooklyn, NY.

N Engl J Med 2020 05;382(21):2066

Weill Cornell Medicine, New York, NY

Surg Technol Int 2020 05;36:179-185

Department of Obstetrics and Gynecology, University of Louisville, School of Medicine, Louisville, Kentucky.

Introduction: Fibroids are highly prevalent among reproductive-aged women and have a significant impact on their wellbeing. Myomectomy is a fertility-sparing option for these patients.

Materials And Methods: This paper is a comprehensive, evidence-based and updated review of literature regarding myomectomy techniques. Read More

Cureus 2020 Apr 16;12(4):e7701. Epub 2020 Apr 16.

Genitourinary Oncology, Creighton University School of Medicine/University of Arizona Cancer Center at Dignity Health St. Joseph's, Phoenix, USA.

Extra-uterine manifestations of benign uterine leiomyoma (fibroids) are rare. Benign metastasizing leiomyoma (BML) comprises an uncommon variant characterized by metastatic lung nodules. The pathologic characteristics for BML are well known in the literature; however, the underlying biology and molecular mechanisms remain poorly understood. Read More

World J Gastrointest Surg 2020 Apr;12(4):171-177

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Gastric subepithelial lesions are frequently encountered during endoscopic examinations, and the majority of them are small and asymptomatic. Among these lesions, gastrointestinal stromal tumors (GISTs) are the major concern for patients and clinicians owing to their malignant potentials. Although previous guidelines suggested periodic surveillance for such small (≤ 20 mm) lesions, several patients and clinicians have still requested or prescribed repeated examinations or radical resection, posing extra medical burdens and risks. Read More

Med Sci Monit 2020 May 19;26:e923749. Epub 2020 May 19.

Department of Gynecology and Obstetrics, The People's Hospital of Wenzhou, Wenzhou, Zhejiang, China (mainland).

BACKGROUND The aim of this study was to investigate STMN1 and MKI67 expression in uterine leiomyosarcoma and their potential roles as biomarkers for diagnosis. MATERIAL AND METHODS The expression of STMN1 and MKI67 mRNA in uterine leiomyosarcoma were investigated in TCGA database. The overall survival (OS) and disease-free survival (DFS) were compared between high and low expression groups. Read More

J Clin Med 2020 May 14;9(5). Epub 2020 May 14.

Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.

Uterine fibroids (UFs) remain a significant health issue for many women, with a disproportionate impact on women of color, likely due to both genetic and environmental factors. The prevalence of UFs is estimated to be approximately 70% depending on population. UF-derived clinical symptoms include pelvic pain, excessive uterine bleeding, gastrointestinal and voiding problems, as well as impaired fertility. Read More

Ecancermedicalscience 2020 6;14:1034. Epub 2020 May 6.

Department of Obstetrics and Gynaecology, Pro-Familia Hospital, Rzeszów, Poland.

Uterine fibroids (UFs) are the most common benign tumours of the female reproductive system and the most frequent reason for hysterectomy worldwide. UFs are reported in 20%-70% of women of reproductive age depending on a study group. Although most women with UFs are asymptomatic, over 30% of them will present with different symptoms. Read More

Cytopathology 2020 May 16. Epub 2020 May 16.

Department of Cytology and Gynecological Pathology, Chandigarh, India.

Venous leiomyoma is an extremely rare entity. We present an interesting case of femoral vein leiomyoma that could be accurately diagnosed pre-operatively based on fine needle aspiration cytology supplemented by immunocytochemistry. The present case demonstrates that a multimodal approach involving appropriate radiologic investigations and fine needle aspiration cytology, supported by immunocytochemistry can help to clinch an accurate pre-operative diagnosis in such cases. Read More

Am J Obstet Gynecol 2020 May 14. Epub 2020 May 14.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Background: Uterine leiomyomas, the most common tumors of the female reproductive system, feature excessive deposition of disordered stiff extracellular matrix (ECM) and fundamentally altered mechanical signaling pathways . Specifically, these alterations impact the normal dynamic state of responsiveness to mechanical cues in the extracellular environment. These mechanical cues are converted via integrins, cell membrane receptors, to biochemical signals including cytoskeletal signaling pathways to maintain mechanical homeostasis. Read More

Sci Rep 2020 May 14;10(1):7993. Epub 2020 May 14.

Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, 02447, Korea.

Although uterine leiomyomas are the most common benign uterine tumors in women, there is no effective therapy that can also preserve the uterus and maintain fertility. The work aimed to work was to discover a potential natural agent that has pharmacological activities on uterine leiomyomas with fewer adverse effects. We chose Rhus verniciflua Stokes (RVS) as a candidate after primary cytotoxicity testing, and analyzed the RVS components that showed pharmacological activity. Read More

Adv Exp Med Biol 2020 ;1242:37-58

Department of Pathology and Molecular Pathology, Centre Jean Perrin, Clermont-Ferrand, France.

Leiomyoma, adenomyosis, and endometrial polyps are benign uterine disorders which seem to develop in the context of hormonal imbalances, due to steroid hormones, estrogen and progesterone, in association with various factors ranging from genetic factors to modifiable lifestyle factors. A growing body of evidence suggests that those hormones and their receptors are key modulators in the genesis and the growth of those pathologic entities. Further studies are required to understand their involvement in the pathogenesis of those lesions and their link to other factors such as extracellular matrix components, growth factors, chemokines, cytokines, and tissue repair mechanisms. Read More

Surg J (N Y) 2020 May 5;6(Suppl 1):S11-S21. Epub 2019 Aug 5.

Department of Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan.

Abdominal myomectomy for a huge myomas, especially uterine cervical myoma, is difficult because of risks, such as intraoperative bleeding or injury to adjacent organs. Therefore, understanding of the positional relationships among a huge myoma, especially cervical or intraligamental myoma, and the vascular plexuses in the right and left cardinal ligaments is important for prevention of massive bleeding during myomectomy. While sufficiently performing preoperative assessment with pelvic examination, ultrasonography, magnetic resonance imaging (MRI), etc. Read More

J Int Med Res 2020 May;48(5):300060520920417

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: This study was performed to quantify hidden blood loss (HBL) and explore its influential factors in myomectomy.

Methods: Two hundred nine patients who underwent myomectomy by laparotomy or laparoscopy from 1 January 2017 to 31 December 2018 were analyzed. Each patient's estimated blood volume and total blood loss (TBL) were calculated by the Nadler formula and Gross formula, respectively. Read More

Urol Case Rep 2020 Sep 24;32:101226. Epub 2020 Apr 24.

Department of Laboratory Medicine & Pathology, Hamad Medical Corporation, Doha, Qatar.

Primary epididymal tumors are rare. Adenomatoid tumors comprise 30% of paratesticular tumors. They are benign neoplasms originating from mesothelial cells. Read More

Cureus 2020 Apr 6;12(4):e7567. Epub 2020 Apr 6.

Internal Medicine/Gastroenterology, Valleywise Health, Phoenix, USA.

Leiomyomas in the colon are uncommon accounting for a few cases of gastrointestinal smooth muscle tumors. These tumors are usually benign and asymptomatic. They may present with abdominal pain, intestinal obstruction, perforation, and rarely hemorrhagic, especially when the tumor is large. Read More

J Med Case Rep 2020 May 8;14(1):55. Epub 2020 May 8.

Endometriosis Research Center, Rasoul Akram Hospital, Iran University of Medical Science, P.O. Box 1445613131, Tehran, Iran.

Background: Fibroids are the most common pelvic tumors in women; serious complications are rare but can be life-threatening.

Case Presentation: We present a case report of a 38-year-old Persian woman with acute abdominal pain and a history of uterine fibroids. The patient refused to undergo a laparoscopic myomectomy. Read More

Complement Ther Clin Pract 2020 May 2;39:101159. Epub 2020 Apr 2.

Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Electronic address:

Background: and purpose: Uterine fibroids are common tumors of the female reproductive system. Symptomatic uterine fibroids require surgical or medical therapy depending on the severity of the symptoms. This study was conducted to investigate the effect of vitamin D on uterine fibroids. Read More

Surg Case Rep 2020 May 6;6(1):92. Epub 2020 May 6.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: The standard surgical method for symptomatic submucosal tumors (SMTs) or tumors with unclear biological behavior is enucleation. Minimally invasive approaches are usually considered appropriate for surgical enucleation; thus, thoracoscopic and laparoscopic enucleation is performed widely and safely. However, it is sometimes difficult to enucleate large and complicated esophageal tumors using thoracoscopic surgery, and even if rare, there is the risk of requiring thoracotomy or esophagectomy. Read More

Cochrane Database Syst Rev 2020 May 6;5:CD013352. Epub 2020 May 6.

Department of Neuroscience, Reproductive Science and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Background: Uterine leiomyomas, also referred to as myomas or fibroids, are benign tumours arising from the smooth muscle cells of the myometrium. They are the most common pelvic tumour in women. The estimated rate of leiomyosarcoma, found during surgery for presumed benign leiomyomas, is about 0. Read More

Ginekol Pol 2020 ;91(4):193-200

Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.

Objectives: To evaluate the incidence of endometriosis among endometritis patients and its association with confounding comorbidities.

Material And Methods: A population-based, retrospective cohort study of women aged between 20 to 55 years, who were newly diagnosed with endometritis between 2000 to 2013. A total of 16,830 endometritis patients and 67,230 non-endometritis individuals were enrolled by accessing data from the National Health Insurance Research Database of Taiwan. Read More

Cancer Med 2020 May 5. Epub 2020 May 5.

Molecular Pathology Research Center, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Intravenous leiomyomatosis (IVL) is currently regarded as a special variant of the common uterine leiomyoma (LM). Though IVL shows a similar histological morphology to LM, IVL is characterized by unique intravenous growth patterns and low-grade malignant potential, which are quite different from LM. There are currently few studies underlying the molecular alterations of IVL, though this information is important for understanding the pathogenesis of the disease, and for identifying potential biomarkers. Read More

Am J Case Rep 2020 May 6;21:e922422. Epub 2020 May 6.

Department of Thoracic Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

BACKGROUND Benign esophageal tumors are considered rare, and most commonly are leiomyomas with the incidence of 0.005%. They arise intramurally in the distal two-thirds of the esophagus and are multiple in about 5% of patients. Read More

Case Rep Womens Health 2020 Jul 20;27:e00205. Epub 2020 Apr 20.

Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, MI 48201, USA.

Background: Leiomyomas are usually easily identifiable on routine imaging. However, there is increasing difficulty with diagnosing leiomyomas following degeneration. Subserosal leiomyomas that undergo cystic degeneration can imitate ovarian pathology. Read More

Urol Case Rep 2020 Sep 12;32:101170. Epub 2020 Apr 12.

Fasa University of Medical Sciences, Urology Department, Iran.

Leiomyoma is a benign tumor originating from smooth muscle cell, Mostly from uterus. However, in men is a very rare entity. Scrotal leiomyoma is a very rare tumor. Read More