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    Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids.
    Clinics (Sao Paulo) 2017 Oct;72(10):637-641
    Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
    Uterine leiomyoma is the most frequently occurring solid pelvic tumor in women during the reproductive period. Magnetic resonance-guided high-intensity focused ultrasound is a promising technique for decreasing menorrhagia and dysmenorrhea in symptomatic women. The aim of this study is to review the role of Magnetic resonance-guided high-intensity focused ultrasound in the treatment of uterine fibroids in symptomatic patients. Read More

    Primary, non-germinal center, double-expressor diffuse large B cell lymphoma confined to a uterine leiomyoma: A case report.
    Gynecol Oncol Rep 2017 Nov 18;22:78-81. Epub 2017 Oct 18.
    University of Louisville School of Medicine, Department of Obstetrics, Gynecology & Women's Health, United States.
    •Primary lymphoma of the female genital tract accounts for 1% of extranodal lymphomas.•Approximately 13% are diffuse large B cell lymphoma of the uterus, most often involving the endometrial stroma or cervix.•The first double-expressor diffuse large B cell lymphoma confined to a uterine leiomyoma is described. Read More

    Organotypic three-dimensional assays based on human leiomyoma-derived matrices.
    Philos Trans R Soc Lond B Biol Sci 2018 Jan;373(1737)
    Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki 0014, Finland.
    Alongside cancer cells, tumours exhibit a complex stroma containing a repertoire of cells, matrix molecules and soluble factors that actively crosstalk between each other. Recognition of this multifaceted concept of the tumour microenvironment (TME) calls for authentic TME mimetics to study cancer in vitro Traditionally, tumourigenesis has been investigated in non-human, three-dimensional rat type I collagen containing organotypic discs or by means of mouse sarcoma-derived gel, such as Matrigel(®) However, the molecular compositions of these simplified assays do not properly simulate human TME. Here, we review the main properties and benefits of using human leiomyoma discs and their matrix Myogel for in vitro assays. Read More

    Incarcerated giant uterine leiomyoma within an incisional hernia: a case report.
    Clin Case Rep 2017 Nov 26;5(11):1837-1840. Epub 2017 Sep 26.
    2nd Department of SurgeryAretaieion University HospitalAthensGreece.
    Uterine leiomyomas presenting as incarcerated or strangulated hernias in surgical emergencies are extremely rare and should be considered in the differential diagnosis in patients with known uterine fibroids and an irreducible ventral abdominal wall hernia. Detailed history and multidisciplinary approach optimize the diagnosis and decision making toward surgical treatment. Read More

    Assessing the risk of laparoscopic morcellation of occult uterine sarcomas during hysterectomy and myomectomy: Literature review and the ISGE recommendations.
    Eur J Obstet Gynecol Reprod Biol 2017 Nov 7;220:30-38. Epub 2017 Nov 7.
    Department of Obstetrics & Gynecology, Nova Medical School - Faculdade de Ciências Médicas, Nova University of Lisbon, Lisbon, Portugal; Department of Obstetrics & Gynecology, Hospital S. Francisco Xavier -- CHLO, Lisbon, Portugal. Electronic address:
    Objective: This project of the International Society for Gynecologic Endoscopy (ISGE) had the objective to review the literature and provide recommendations on the occult sarcoma risk assessment in patients who are candidates for minimally invasive gynecological surgery involving intra-abdominal electromechanical tissue morcellation.

    Study Design: The ISGE Task Force for Estimation of the Risk in Endoscopic Morcellation initially defined key topics and clinical questions which may guide a comprehensive preoperative patient assessment. A literature search within the Medline/PubMed and Cochrane Database was carried out using keywords "morcellation", "uterine fibroids", "uterine sarcoma", "myomectomy" and "hysterectomy". Read More

    Role of Transforming Growth Factor β in Uterine Fibroid Biology.
    Int J Mol Sci 2017 Nov 17;18(11). Epub 2017 Nov 17.
    First Department of Obstetrics and Gynecology, The Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland.
    Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3. Read More

    Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China.
    Chin Med J (Engl) 2017 Nov;130(22):2661-2665
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, China.
    Background: The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy.

    Methods: A national multicenter study was performed in China. Read More

    Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.
    Biol Reprod 2017 Nov 8. Epub 2017 Nov 8.
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, Pittsburgh, PA 15213, USA.
    The transcriptional factor MED12 is part of the essential mediator transcriptional complex that acts as a transcriptional coactivator in all eukaryotes. Missense gain of function mutations in human MED12 are associated with uterine leiomyomas, yet the role of MED12 deficiency in tumorigenesis and reproductive biology has not been fully explored. We generated a Med12 reproductive conditional knockout mouse model to evaluate its role in uterine mesenchyme, granulosa cells, and oocytes. Read More

    Polymorphisms of mitochondrial DNA control region are associated to endometriosis.
    J Assist Reprod Genet 2017 Nov 9. Epub 2017 Nov 9.
    Gynecologic Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
    Purpose: Polymorphisms in the control region of mitochondrial DNA (mtDNA) can affect generation of reactive oxygen species and impact in the pathogenesis of endometriosis. This study investigated the association of mtDNA polymorphisms with endometriosis.

    Methods: Patients were divided in two groups: endometriosis (n = 90) and control (n = 92). Read More

    Tissue Extraction Techniques for Leiomyomas and Uteri During Minimally Invasive Surgery.
    Obstet Gynecol 2017 Nov 3. Epub 2017 Nov 3.
    Center for Minimally Invasive Gynecologic Surgery, Cedars-Sinai Medical Center, Los Angeles, California; and the Division of Minimally Invasive Gynecologic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
    Fragmented tissue extraction (morcellation) of uterine and leiomyoma tissue in gynecologic surgery has been performed for decades, but recent years have seen a vast expansion of techniques to address risks associated with tissue dispersion. Use of power, or electromechanical, morcellation has largely been replaced by manual morcellation with a scalpel. Morcellation can take place through a laparoscopic incision, a minilaparotomy incision, or through a colpotomy. Read More

    Case of chromothripsis in a large solitary non-recurrent uterine leiomyoma.
    Eur J Obstet Gynecol Reprod Biol 2017 Dec 1;219:134-136. Epub 2017 Nov 1.
    D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya line, 3, 199034, St. Petersburg, Russia; St. Petersburg State University, Universitetskaya emb., 7/9, 199034, St. Petersburg, Russia; S.M. Kirov Military Medical Academy, Lebedeva st., 6, 194044, St. Petersburg, Russia.

    The uterine leiomyoma and placenta previa: a meta-analysis.
    J Matern Fetal Neonatal Med 2017 Nov 21:1-5. Epub 2017 Nov 21.
    b Midwife in Social Security Organization , Hamadan , Iran.
    Background: Some epidemiological studies have reported that uterine leiomyoma may increase the risk of placenta previa. To date, the meta-analysis has not been carried out for assessing the relationship between uterine leiomyoma and placenta previa. This meta-analysis was carried out to estimate the association between uterine leiomyoma and the risk of placenta previa. Read More

    Pilot study: safety and effectiveness of simple ultrasound-guided high-intensity focused ultrasound ablating uterine leiomyoma with a diameter greater than 10 cm.
    Br J Radiol 2017 Nov 21:20160950. Epub 2017 Nov 21.
    1 Department of Gynecology and Gynecology and Obstetrics,The First Affiliated Hospital of Xinxiang Medical University , The First Affiliated Hospital of Xinxiang Medical University , Weihui, Henan , PR China.
    Objective: The study aimed to prospectively investigate whether uterine leiomyoma greater than 10 cm in diameter could be treated with simple ultrasound-guided high-intensity focused ultrasound (USgHIFU) in one-time treatment.

    Methods: A total of 36 patients with 36 symptomatic uterine leiomyoma greater than 10 cm in diameter who underwent simple USgHIFU treatment alone were analysed. Enhanced MRI was performed before and after HIFU treatment, and all patients had follow-up for 6 months after treatment. Read More

    Metastasis of breast cancer to an endometrial polyp, the cervix and a leiomyoma: A case report and review of the literature.
    Oncol Lett 2017 Oct 24;14(4):4585-4592. Epub 2017 Aug 24.
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan.
    Haematogenous metastases of breast cancer tumors has previously been demonstrated to frequently occur at the sites of the lung, bones, liver and brain, however presence in the uterine remains a rare occurrence. Metastatic carcinoma of the uterus usually originates from other genital sites, most frequently from the ovaries. The current review presents the first reported case of lobular breast carcinoma metastasizing to an endometrial polyp, the cervix and a leiomyoma simultaneously. Read More

    Magnetic Resonance Imaging Grading System for Preoperative Diagnosis of Leiomyomas and Uterine Smooth Muscle Tumors.
    J Minim Invasive Gynecol 2017 Oct 24. Epub 2017 Oct 24.
    Departments of Obstetrics and Gynecology, Teine Keijinkai Hospital, Sapporo, Japan.
    Study Objective: To evaluate a new magnetic resonance imaging (MRI) grading system for preoperative differentiation between benign and variant-type uterine leiomyomas including smooth muscle tumors of uncertain malignant potential (STUMPs).

    Design: Retrospective analysis (Canadian Task Force classification III).

    Setting: Teaching hospital (Teine Keijinkai Hospital). Read More

    Clinical value of endoscopic ultrasonography for esophageal leiomyoma in elder patients.
    J Vis Surg 2017 30;3:137. Epub 2017 Sep 30.
    Departments of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
    Background: It's hard for conventional endoscopy to make a distinction between esophageal leiomyoma and submucosal lesions. The clinical features of elder patients with esophageal leiomyoma may be different with non-elder ones. This study examined the clinical value of endoscopic ultrasonography (EUS) in patients with esophageal leiomyoma, conclude the clinical characteristics of them, especially elder ones. Read More

    Left video-assisted thoracoscopic enucleation of a giant horseshoe oesophageal leiomyoma.
    J Vis Surg 2017 4;3:63. Epub 2017 May 4.
    Mount Elizabeth Medical Centre, Singapore.
    Oesophageal leiomyomas are rare neoplasms of the oesophagus, accounting for approximately 4% of all oesophageal tumours. Most oesophageal leiomyomas are small and well encapsulated. We report a rare case of a giant horseshoe oesophageal leiomyoma which was removed via video-assisted thoracoscopic enucleation and describe the management of an intra-operative complication of a mucosal breach. Read More

    DNA fragmentation factors 40 and 45 (DFF40/DFF45) and B-cell lymphoma 2 (Bcl-2) protein are underexpressed in uterine leiomyosarcomas and may predict survival.
    Onco Targets Ther 2017 14;10:4579-4589. Epub 2017 Sep 14.
    Department of Public Health, Faculty of Health Science, Medical University of Warsaw.
    Objectives: DNA fragmentation factors 40 and 45 (DFF40 and DFF45) are responsible for final DNA-laddering during apoptosis, whereas Bcl-2 (B-cell lymphoma 2) is an apoptosis inhibitor. Our aim was to investigate the expression of DFF40, DFF45, and Bcl-2 in uterine leiomyosarcomas (uLMS), leiomyomas (uLM), and the normal myometrium. Furthermore, the correlation between DFF40, DFF45, and Bcl-2 expression and clinicopathological parameters in leiomyosarcomas was assessed. Read More

    Ciliary Body Mesectodermal Leiomyoma Diagnosed by Fine Needle Aspiration Biopsy.
    Ocul Oncol Pathol 2017 Sep 15;3(3):199-203. Epub 2017 Feb 15.
    Department of Pathology, Hacettepe University, School of Medicine, Ankara, Turkey.
    Aims: To describe the clinical, imaging, cytopathological, and immunohistochemical features of mesectodermal leiomyoma of the ciliary body diagnosed by fine needle aspiration biopsy in a patient who denied any major intervention without prior pathological verification.

    Methods: The clinical, imaging, and cytopathological records of the patient were retrospectively reviewed. A fine needle aspiration biopsy with a 25-G needle was performed after tailoring a scleral flap. Read More

    25-Hydroxy vitamin D levels in premenopausal Turkish women with uterine leiomyoma.
    Gynecol Endocrinol 2017 Oct 25:1-4. Epub 2017 Oct 25.
    a Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
    We aimed to evaluate the relationship between serum 25-hydroxy vitamin D levels and the risk of uterine fibroids in premenopausal women in Turkish population in this prospective observational cross-sectional study. Sixty-eight women with at least one uterine leiomyoma ≥10 mm were compared with 56 healthy controls. Serum 25-(OH) vitamin D3 levels were measured by electrochemiluminescence immunoassay. Read More

    Successful maternal and perinatal outcomes in a term pregnancy with giant abdominopelvic leiomyomatosis.
    BMJ Case Rep 2017 Oct 24;2017. Epub 2017 Oct 24.
    Department of Surgery, All India Institute of Medical Sciences, New Delhi, India.
    A 30-year-old second gravida with history of laparoscopic myomectomy and one previous caesarean section was admitted at 31 weeks and 2 days period of gestation (POG) with a diagnosis of diffuse abdominopelvic leiomyomatosis and moderate anaemia. After correction of anaemia with intravenous iron and erythropoietin, laparotomy was performed at 37 weeks POG. A healthy female baby weighing 2. Read More

    A case of laparoscopy-assisted vaginal cuff suturing for vaginal cuff dehiscence after total laparoscopic hysterectomy.
    Int J Surg Case Rep 2017 Oct 18;41:110-113. Epub 2017 Oct 18.
    Department of Obstetrics and Gynecology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan. Electronic address:
    Introduction: Vaginal cuff dehiscence after hysterectomy is a rare complication and occurs in less than 1% of patients. It can present with serious complications, such as bowel evisceration and peritonitis.

    Presentation Of Case: A 51-year-old multigravida Korean woman underwent total laparoscopic hysterectomy for leiomyoma. Read More

    Giant angioleiomyoma of the sacral foramina: an unusual location.
    Skeletal Radiol 2017 Oct 20. Epub 2017 Oct 20.
    Department of Pathology, CHA Bundang Medical Center, CHA University, College of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
    Angioleiomyoma is a benign, vascular smooth muscle tumor originating from the tunica media of the vessel wall. In general, it typically arises in the cutaneous, subcutaneous tissue or fascia of the lower extremities in middle-aged women and is less than 2 cm in diameter. We report an unusual case of an angioleiomyoma of the sacral foramina in an 82-year-old man. Read More

    A Rare Case Report of a Paratesticular Fibrous Pseudotumor Mimicking a Hydrocele.
    Cureus 2017 Aug 14;9(8):e1565. Epub 2017 Aug 14.
    Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
    Tumors arising in the spermatic cord are very rare. The common benign tumors of the spermatic cord include adenomatoid tumor, lipoma, neurofibroma, and leiomyoma. We report a rare case of fibrous pseudotumor of the spermatic cord presenting clinically as a hydrocele. Read More

    Subtype-specific tumor-associated fibroblasts contribute to the pathogenesis of uterine leiomyoma.
    Cancer Res 2017 Oct 20. Epub 2017 Oct 20.
    Department of Cancer Biology and Genetics, Ohio State University
    Recent genomic studies have identified subtypes of uterine leiomyoma (LM) with distinctive genetic alterations. Here we report the elucidation of the biological characteristics of the two most prevalent LM subtypes, MED12 mutant (MED12-LM) and HMGA2-overexpressing (HMGA2-LM) LM. Since each tumor carries only one genetic alteration, both subtypes are considered to be monoclonal. Read More

    Parasitic leiomyoma: A case report with literature review.
    Int J Surg Case Rep 2017 Oct 6;41:33-35. Epub 2017 Oct 6.
    Sulaimani Teaching Hospital, Department of Pathology, Sulaimani, Kurdistan, Iraq.
    Introduction: Parasitic leiomyoma is an extremely rare variant of uterine leiomyoma occurring outside uterus. The aim of this study is to report a case of parasitic leiomyoma with brief literature report.

    Case Report: A 46-yearo-old lady presented with upper abdominal heaviness and swelling of about 6year duration. Read More

    Recurrent Pneumothoraces in a Patient With Pulmonary Benign Metastasizing Leiomyoma.
    Ochsner J 2017 ;17(3):284-287
    The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
    Background: Pulmonary benign metastasizing leiomyoma (BML) is a rare disease with a malignant characteristic of spread from the uterus. Most cases are asymptomatic, and only 1% are associated with pneumothorax.

    Case Report: We present the case of a 42-year-old female with recurrent pneumothoraces leading to an incidental finding of diffuse bilateral pulmonary nodules. Read More

    Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids.
    Biol Reprod 2017 Sep;97(3):337-352
    Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
    Uterine fibroids (UFs, AKA leiomyoma) are the most important benign neoplastic threat to women's health, with costs up to hundreds of billions of health care dollars worldwide. Uterine fibroids caused morbidities exert a tremendous health toll, impacting the quality of life of women of all ethnicities, especially women of color. Clinical presentations include heavy vaginal bleeding, pelvic pain, bulk symptoms, subfertility, and obstetric complications. Read More

    ERα36, a variant of estrogen receptor α, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells.
    PLoS One 2017 11;12(10):e0186078. Epub 2017 Oct 11.
    Molecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, North Carolina, United States of America.
    ERα36 is a naturally occurring, membrane-associated, isoform of estrogen receptor α. The expression of ERα36 is due to alternative splicing and different promoter usage. ERα36 is a dominant-negative effector of ERα66-mediated transactivational activities and has the potential to trigger membrane-initiated mitogenic, nongenomic, estrogen signaling; however, the subcellular localization of ERα36 remains controversial. Read More

    Change in Surgical Practice for Women With Leiomyomas After the U.S. Food and Drug Administration Morcellator Safety Communication.
    Obstet Gynecol 2017 Nov;130(5):1057-1063
    University of California, San Francisco School of Medicine, and the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California.
    Objective: To evaluate the association between the U.S. Food and Drug Administration (FDA) communication discouraging use of power morcellators on changes in surgical practice for women with uterine leiomyomas. Read More

    Comparative Effectiveness of Uterine Leiomyoma Procedures Using a Large Insurance Claims Database.
    Obstet Gynecol 2017 Nov;130(5):1047-1056
    Departments of Health Sciences Research, Obstetrics and Gynecology, and Surgery and the Kern Center for Science of Health Care Delivery, Mayo Clinic, and the Departments of Obstetrics-Gynecology and Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota.
    Objective: To compare risk of reintervention, long-term clinical outcomes, and health care utilization among women who have bulk symptoms from leiomyoma and who underwent the following procedures: hysterectomy, myomectomy, uterine artery embolization, and magnetic resonance-guided, focused ultrasound surgery.

    Methods: This was a retrospective analysis of administrative claims from a large U.S. Read More

    Leiomyomas in Pregnancy and Spontaneous Abortion: A Systematic Review and Meta-analysis.
    Obstet Gynecol 2017 Nov;130(5):1065-1072
    Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, the Vanderbilt Genetics Institute, the Evidence-Based Practice Center, and the Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.
    Objective: To systematically review studies reporting the risk of spontaneous abortion among pregnant women of typical reproductive potential with and without uterine leiomyomas.

    Data Sources: We searched PubMed, EMBASE, Web of Science, and ClinicalTrials.gov for publications from January 1970 to December 2016. Read More

    A case report of angioleiomyoma of uterus.
    Obstet Gynecol Sci 2017 Sep 18;60(5):494-497. Epub 2017 Sep 18.
    Department of Obstetrics and Gynecology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
    Angioleiomyoma (AL) is a very rare benign tumor that originates from smooth muscle cells and has thick walled vessels. It may be found throughout the body but more frequently occurs in the lower extremities and rarely develops in the head and other parts of the body. This paper presents a case report of giant AL detected in a 33-year-old woman who complained of severe anemia, menorrhagia, and palpable lower abdominal mass. Read More

    Delayed intestinal perforation and vertebral osteomyelitis after high-intensity focused ultrasound treatment for uterine leiomyoma.
    Obstet Gynecol Sci 2017 Sep 18;60(5):490-493. Epub 2017 Sep 18.
    Department of Obstetrics and Gynecology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang, Korea.
    High-intensity focused ultrasound (HIFU) is a non-invasive uterine fibroid treatment option for patients who want to preserve fertility. However, according to several reports regarding ablation of solid tumors by HIFU, there are rare complications in patients with uterine leiomyomas, and overall data are still insufficient. Here, we report rare and major complications of HIFU, such as delayed intestinal perforation, uterine perforation with recto-uterine fistula, and osteomyelitis 29 days after the HIFU procedure to treat multiple myomas. Read More

    Metastatic uterine cancer looking as cervical fibroid in recurrent breast cancer woman: a case report.
    Obstet Gynecol Sci 2017 Sep 18;60(5):481-484. Epub 2017 Sep 18.
    Department of Obstetrics and Gynecology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
    Metastasis to the female genital tract from extragenital primary cancer is uncommon. In this case, a 46-year-old woman was diagnosed with invasive lobular carcinoma of the left breast in 2011. She had left breast conserving surgery, chemotherapy, radiation, and hormonal therapy (gosereline and tamoxifen). Read More

    Angioleiomyoma of Uterus Masquerading as Malignant Ovarian Tumor.
    J Midlife Health 2017 Jul-Sep;8(3):145-147
    Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
    Uterine angioleiomyoma is rare. A 40-year-old nulliparous woman presented with heavy menstrual bleeding (HMB) for the past 2 years and mass per abdomen with severe dysmenorrhea for three cycles. She had received 8 units of packed cell transfusion outside. Read More

    MRI for adenomyosis: a pictorial review.
    Insights Imaging 2017 Oct 4. Epub 2017 Oct 4.
    Department of Radiology, Hospital da Luz, Lisbon, Portugal.
    Adenomyosis is defined as the presence of ectopic endometrial glands and stroma within the myometrium. It is a disease of the inner myometrium and results from infiltration of the basal endometrium into the underlying myometrium. Transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) are the main radiologic tools for this condition. Read More

    Leiomyoma of the breast parenchyma: a case report and review of the literature.
    Sao Paulo Med J 2017 Sep 18. Epub 2017 Sep 18.
    Medical Doctor, Doctorate in Medicine, Full Professor and Head of the Discipline of Mastology, Department of Gynecology, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.
    Introduction: Benign tumors are often seen in breast screening examinations. However, the differential diagnosis is not always simple because of radiological similarity between the different benign lesions.

    Case Report: We present a rare case report of leiomyoma of the breast parenchyma in a 68-year-old asymptomatic patient. Read More

    Puerperal Complications of a Retroplacental Uterine Leiomyoma.
    J Am Osteopath Assoc 2017 Oct;117(10):660-663
    Leiomyoma can be found concomitant with pregnancy and can cause complications during labor, delivery, and postpartum management. In the present case, a 26-year-old nulliparous patient at 39.4 weeks gestational age with a 12×9-cm retroplacental leiomyoma underwent a spontaneous vaginal delivery. Read More

    Sentinel Lymph Node Ultra-staging as a Supplement for Endometrial Cancer Intraoperative Frozen Section Deficiencies.
    Int J Gynecol Pathol 2017 Sep 29. Epub 2017 Sep 29.
    Department of Pathology (M.B.) Division of Gynecologic Pathology (Y.L., T.K.) Gynecologic Oncology (J.R., M.P.-H., N.N., N.N.), Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York Department of Pathology, Englewood Hospital and Medical Center, Englewood, New Jersey (M.T.) Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts (X.W., K.A.D.).
    For endometrial cancer (EC), most surgeons rely on intraoperative frozen section (IFS) to determine the risk of nodal metastasis and necessity of lymphadenectomy. IFS remains a weak link in this practice due to its susceptibility to diagnostic errors. As a less invasive alternative, sentinel lymph node (SLN) mapping and ultra-staging have gradually gained acceptance for EC. Read More

    Leiomyomatosis peritonealis disseminata: A case report and meticulous review of the literature.
    Int J Surg Case Rep 2017 23;40:105-108. Epub 2017 Sep 23.
    University Department of Surgery, General and Oncologic Hospital of Kifissia "Agii Anargiri", Athens, Greece; Anatomy and Histology Laboratory, Nursing School, University of Athens, Greece.
    Introduction: Leiomyomatosis peritonealis disseminata (LPD) is a peculiar benign clinical disorder characterized by proliferation of peritoneal and subperitoneal nodules. LPD is a difficultly diagnosed benign disease that rarely degenerates into malignancy.

    Presentation Of Case: A 40-year-old Caucasian female with vaginal bleeding proceeded to our institution for elective excision of abdominal and pelvic masses which were firstly considered as leiomyosarcomas. Read More

    A rare case of benign metastasizing leiomyoma(†).
    J Surg Case Rep 2017 Sep 21;2017(9):rjx190. Epub 2017 Sep 21.
    Royal Victoria Hospital, Belfast BT12 6BA, UK.
    Benign metastasizing leiomyoma is a rare disorder involving distant metastases secondary to a smooth muscle tumour of the myometrium. This case report describes a 48-year-old woman with multiple pulmonary nodules noted on post-operative chest x-ray. Further investigation revealed a history of total abdominal hysterectomy for benign fibroids of the uterus, 6 years prior to the scan. Read More

    Suppression of MAGE-A10 alters the metastatic phenotype of tongue squamous cell carcinoma cells.
    Biochem Biophys Rep 2017 Jul 19;10:267-275. Epub 2017 Apr 19.
    Instituto de Bioquímica Médica Leopoldo de Meis, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro Ilha do Fundão CEP 21941-902 Rio de Janeiro, Brazil.
    MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2). Read More

    Uterine fibroids: correlations between MRI appearance and stiffness via magnetic resonance elastography.
    Abdom Radiol (NY) 2017 Sep 26. Epub 2017 Sep 26.
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
    Rationale And Objectives: Magnetic resonance elastography has proven to be a valuable tool in the diagnosis of liver fibrosis, breast and cervical cancer, but its application in uterine fibroids requires further characterization. The aim of the present study was to examine the relationship between uterine fibroid stiffness by MRE and MR imaging characteristics.

    Materials And Methods: An IRB-approved, HIPAA compliant review was performed of prospectively collected pelvic MRI and 2D-MRE data in patients with symptomatic uterine fibroids (N = 102). Read More

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