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    1 OF 434

    Extra-mucosal enucleation is still a safe and feasible treatment option of giant esophageal leiomyomas.
    Indian J Gastroenterol 2018 Feb 21. Epub 2018 Feb 21.
    Department of GI Surgery, GI Oncology, MAS and Bariatric Surgery, Medanta, The Medicity, Sector 38, Gurgaon, 122 018, India.
    Esophageal leiomyoma (EL) is rare but still the most common benign tumor of the esophagus. Extra-mucosal enucleation (EME) is the treatment of choice. Many recent reports have favored esophageal resection for giant Esophageal leiomyomas (ELs). Read More

    Single port access laparoscopic subtotal hysterectomy using contained manual morcellation: Experience from a tertiary referral center in Taiwan.
    Taiwan J Obstet Gynecol 2018 Feb;57(1):28-31
    Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
    Objective: To describe the surgical outcomes of single port access laparoscopic subtotal hysterectomy (LSH) using in-bag manual morcellation and evaluate the feasibility of this procedure.

    Materials And Methods: Thirty patients with symptomatic leiomyoma or adenomyosis were enrolled. A 2-cm transverse incision was made at the umbilicus and single port apparatus (LagiPort) was applied. Read More

    Ovarian leiomyoma with myxoid stroma.
    Pathologica 2017 Dec;109(4):389-391
    Department of Histopathology, Imperial College London, UK.
    Ovarian smooth muscle tumours are rare. Notable myxoid change in smooth muscle tumours is uncommon, and raises diagnostic issues that need to be considered on evaluating a spindle cell lesion with notable myxoid change. There is only one case of myxoid leiomyoma of the ovary previously reported. Read More

    Gastrointestinal stromal tumor of the esophagus: current issues of diagnosis, surgery and drug therapy.
    Transl Gastroenterol Hepatol 2018 22;3. Epub 2018 Jan 22.
    Department of Surgery, Hiroshima City Asa Citizens Hospital, Asakita-ku, Hiroshima, Japan.
    Gastrointestinal stromal tumors (GISTs) often arise in the stomach and small intestine, while esophageal GISTs are rare. Due to their rarity, clinicopathological data on esophageal GISTs are extremely limited, and this results in a lack of clear recommendations concerning optimal surgical management for esophageal GISTs. It is difficult to distinguish esophageal GIST from leiomyoma, the most frequent esophageal mesenchymal tumor, prior to resection, because the two types of tumors appear similar on computed tomography (CT), endoscopic ultrasound (EUS), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Read More

    Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of Cyclin C-CDK8/19.
    J Biol Chem 2018 Feb 13. Epub 2018 Feb 13.
    Molecular Medicine, University of Texas Health Science Center at San Antonio, United States.
    Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked mutations in MED12 disrupt its ability to activate CycC-dependent kinase 8 (CDK8), implicating impaired Mediator-associated CDK8 activity in the pathogenesis of these clinically significant lesions. Notably, the CDK8 paralog CDK19 is also expressed in myometrium, and both CDK8 and CDK19 assemble into Mediator in a mutually exclusive manner, suggesting that CDK19 activity may also be germane to the pathogenesis of MED12 mutation-induced UFs. Read More

    Rare symptomatic bladder leiomyoma: case report and literature review.
    J Int Med Res 2018 Jan 1:300060517752732. Epub 2018 Jan 1.
    1 Department of Urology, First Hospital of Jilin University, Changchun, China.
    Bladder leiomyoma is a rare, benign tumour of the bladder. We present a clinical case of a 47-year-old asymptomatic woman with symptomatic bladder leiomyoma. Computed tomography showed well-defined bladder leiomyoma in the right posterior bladder wall. Read More

    Metastatic Epicardial Leiomyoma with uncertain malignant potential.
    J Surg Case Rep 2017 Sep 18;2017(9):rjx179. Epub 2017 Sep 18.
    Department of Surgery, Tufts Medical Center and Tufts School of Medicine, Boston, MA, USA.
    A 49-year-old female with history of uterine leiomyoma and intermittent shortness of breath presented to the emergency department with new onset of tachycardia and chest pain. Subsequent cardiac work up revealed hypoechoic mass compressing the right ventricle. Computer tomography guided biopsy for tissue characterization revealed a benign spindle cell tumor. Read More

    Utility of Clinical Parameters and Multiparametric MRI as Predictive Factors for Differentiating Uterine Sarcoma From Atypical Leiomyoma.
    Acad Radiol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, China.
    Objectives: The objective of this study was to find clinical parameters and qualitative and quantitative magnetic resonance imaging (MRI) features for differentiating uterine sarcoma from atypical leiomyoma (ALM) preoperatively and to calculate predictive values for uterine sarcoma.

    Materials And Methods: Data from 60 patients with uterine sarcoma and 88 patients with ALM confirmed by surgery and pathology were collected. Clinical parameters, qualitative MRI features, diffusion-weighted imaging with apparent diffusion coefficient values, and quantitative parameters of dynamic contrast-enhanced MRI of these two tumor types were compared. Read More

    Differential Diagnosis of Benign Spindle Cell Lesions.
    Surg Pathol Clin 2018 Mar 9;11(1):91-121. Epub 2017 Dec 9.
    Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology, University of Catania, Via S. Sofia 87, Catania 95123, Italy. Electronic address:
    Spindle cell lesions of the breast cover a wide spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors. The recognition of the benign spindle cell tumor-like lesions (nodular fasciitis; reactive spindle cell nodule after biopsy, inflammatory pseudotumor/inflammatory myofibroblastic tumor; fascicular variant of pseudoangiomatous stromal hyperplasia) and tumors (myofibroblastoma, benign fibroblastic spindle cell tumor, leiomyoma, schwannoma, spindle cell lipoma, solitary fibrous tumor, myxoma) is crucial to avoid confusion with morphologically similar but more aggressive bland-appearing spindle cell tumors, such as desmoid-type fibromatosis, low-grade (fibromatosis-like) spindle cell carcinoma, low-grade fibrosarcoma/myofibroblastic sarcoma and dermatofibrosarcoma protuberans. Read More

    Ulipristal acetate for pre-operative management of uterine fibroids: Modeling outcomes and costs.
    Eur J Obstet Gynecol Reprod Biol 2018 Mar 3;222:84-88. Epub 2018 Feb 3.
    Scientific Direction, SIFACT, Italian Society for Clinical Pharmacy and Therapeutics, Milano, Italy.
    Objectives: The aim of this study was to evaluate the pharmacoeconomic profile in Italy of preoperative treatment with ulipristal acetate at the dose of 5 mg/day for 13 weeks in comparison with placebo prior to surgical management of symptomatic uterine fibroids.

    Study Design: The pharmacoeconomic analysis was based on the calculation of incremental cost-effectiveness ratio (ICER). Effectiveness data were derived from the randomized-controlled trial PEARL-1, whilst costs data were retrieved from the published literature. Read More

    Irrigation after Laparoscopic Power Morcellation and the Dispersal of Leiomyoma Cells: a Pilot Study.
    J Minim Invasive Gynecol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
    Study Objective: To evaluate if copious irrigation and suctioning after electro-mechanical power morcellation will reduce myoma cell dissemination, and if there is a difference between sterile water and normal saline.

    Design: Prospective single-center cohort pilot study (Canadian Task Force Classification II-2) SETTING: Academic tertiary referral center PATIENTS: Sixteen women undergoing laparoscopic myomectomy with one surgeon between January 1, 2017 and August 31, 2017.

    Interventions: Peritoneal washings were collected three specific times during surgery: after dissection of myoma(s) and hysterotomy repair but before morcellation, after morcellation, and after irrigation with 3 L of normal saline or sterile water. Read More

    A Case Report of an Adenomatoid Tumor of the Uterus Mimicking an Endometrioid Adenocarcinoma on Endometrial Curetting: a Diagnostic Pitfall.
    Appl Immunohistochem Mol Morphol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Pathology, Aurora Diagnostic Laboratory, Las Vegas, NV.
    Adenomatoid tumors (AT) arising in the female genital tract are usually incidental findings occurring most often in the fallopian tube and uterine serosa and rarely in the myometrium. In the myometrium, they appear grossly as deep seated, small, firm, ill circumscribed nodules mimicking leiomyoma. Histologically they show a glandular and invasive pattern making well-differentiated/low-grade endometrioid adenocarcinoma a major differential diagnosis. Read More

    What MRI features suspect malignant pure mesenchymal uterine tumors rather than uterine leiomyoma with cystic degeneration?
    J Gynecol Oncol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
    Objective: To retrospectively assess conventional magnetic resonance imaging (MRI) features that differentiate malignant pure mesenchymal uterine tumors (MPMUT); endometrial stromal sarcoma (ESS) and leiomyosarcoma (LMS) from uterine leiomyoma with cystic degeneration (ULCD).

    Methods: We retrospectively reviewed magnetic resonance (MR) images of 30 patients with ULCD, 18 with ESS, and 15 with LMS, to assess tumor location, margin, T2 signal intensity (SI), speckled appearance, and peripheral band using univariate and multivariate analyses.

    Results: ULCD more frequently showed subserosal location (53. Read More

    Clinical Characteristics Differentiating Uterine Sarcoma and Fibroids.
    JSLS 2018 Jan-Mar;22(1)
    Department of Obstetrics and Gynaecology, University of Ottawa and the Ottawa Hospital Research Institute.
    Background And Objectives: Uterine fibroids are a common indication for laparoscopy. Unsuspected sarcoma can pose a serious risk if morcellation is used in the procedure. We sought to determine the clinical factors associated with uterine sarcoma compared with uterine fibroids. Read More

    Novel TRERF1 mutations in Chinese patients with ovarian endometriosis.
    Mol Med Rep 2018 Jan 26. Epub 2018 Jan 26.
    Department of Gynecology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, P.R. China.
    Endometriosis is an estrogen-dependent precancerous lesion exhibiting frequently perturbed level of steroid hormones and transcriptional‑regulating factor 1 (TRERF1) has a crucial role in the production of steroid hormones including estrogen. Endometriosis has previously been revealed to be a precancerous lesion that harbors somatic mutations in cancer‑associated genes. Therefore, the authors of the present study hypothesize that TRERF1 aberrations may be involved in the development of endometriosis. Read More

    Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations.
    J Turk Ger Gynecol Assoc 2018 Feb 2. Epub 2018 Feb 2.
    Objective: The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.

    Material And Methods: For genotyping the fok1 polymorphism of vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v. Read More

    Uterine fibroids with positive 18F-FDG PET/CT image and significantly increased CA19-9: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9421
    Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
    Rationale: Uterine fibroids are the most common pelvic solid tumors and common to 25% of women. F-fluorodexyglucose (F-FDG) is an energy metabolism tracer. Although FDG is generally concentrated in malignant lesions with high glucose metabolism, it can also accumulate in normal tissues, benign lesions, and inflammatory sites. Read More

    Clinical evaluation of improved MyoSure hysteroscopic tissue removal system for the resection of type II submucosal myomas.
    Medicine (Baltimore) 2017 Dec;96(50):e9363
    Gynaecology and Obstetrics, Huzhou Maternity and Child Care Hospital, Huzhou, Zhejiang, China.
    This study aims to determine whether clinical evaluation of improved MyoSure hysteroscopic tissue removal system can remove type II submucosal myomas with safety and high success rate of the first operation.Fifty-three patients with type II submucosal myomas hospitalized in the Huzhou Maternity and Child Care Hospital were enrolled in this study. The submucosal myomas were with the diameter of >2 cm and ≤5 cm. Read More

    Leiomyoma on gingiva with osseous involvement: An unusual presentation.
    J Indian Soc Periodontol 2017 Jan-Feb;21(1):60-62
    Department of Periodontology, GDC and H, Mumbai, Maharashtra, India.
    Leiomyoma is a smooth muscle tumor which rarely turns into malignancy. This is an unusual case report which presents leiomyoma on gingiva with osseous involvement. This case highlights the importance of histopathological examination for the proper diagnosis of any gingival growth. Read More

    Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene.
    BMC Med Genet 2018 Jan 31;19(1):20. Epub 2018 Jan 31.
    Institute of Clinical Medicine, Department of Obstetrics and Gynaecology, University of Tartu, Tartu, Estonia.
    Background: Benign metastasizing leiomyoma (BML) is an orphan neoplasm commonly characterized by pulmonary metastases consisting of smooth muscle cells. Patients with BML have usually a current or previous uterine leiomyoma, which is therefore suggested to be the most probable source of this tumour. The purpose of this case report was to determine the possible genetic grounds for pulmonary BML. Read More

    Overexpression of the 14-3-3γ protein in uterine leiomyoma cells results in growth retardation and increased apoptosis.
    Cell Signal 2018 Jan 30;45:43-53. Epub 2018 Jan 30.
    Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:
    Protein 14-3-3γ was significantly reduced in human uterine leiomyoma compared to the adjacent normal myometrium tissue. To investigate the possible link between the reduced 14-3-3γ expression and uterine leiomyoma growth, we have overexpressed 14-3-3γ protein in uterine leiomyomal cells and its effects on cell proliferation and apoptosis were analyzed. Over-expression of 14-3-3γ was achieved by transducing into two types of uterine leiomyoma cells (primary culture cells and immortal stem cells) with a 14-3-3γ expressing adenovirus vector. Read More

    Calcifying fibrous tumor of stomach: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8882
    Department of Pathology, Gongli Hospital, Second Military Medical University, Shanghai, China.
    Rationale: Calcifying fibrous tumor (CFT) is a rare benign soft tissue mesenchymal neoplasm. Although the gastrointestinal (GI) tract is the most common predilection site of CFT, the clinicians, even including pathologist, generally consider it as GI stromal tumor (GIST) or other submucosal tumors such as schwannoma and leiomyoma.

    Patient Concerns: A 55-year-old man presented with complaints of epigastric discomfort and abdominal distention for more than 1 year. Read More

    The AKT/BCL-2 axis mediates survival of uterine leiomyoma in a novel 3D spheroid model.
    Endocrinology 2018 Jan 26. Epub 2018 Jan 26.
    Division of Reproductive Science and Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA.
    A deeper understanding of the pathways that drive uterine leiomyoma (ULM) growth and survival requires model systems that more closely mimic the in vivo tumors. This would provide new insights into developing effective therapeutic strategies for these common benign tumors of childbearing-aged women. In this study, we examined the role of BCL-2 in mediating ULM survival in the context of increased AKT and oxidative stress using a novel 3-dimensional (3D), spheroid-based model that more closely resembles the native ULM tumor microenvironment. Read More

    Increased Risk of Venous Thromboembolism in Women with Uterine Leiomyoma: A Nationwide, Population-Based Case-Control Study.
    Acta Cardiol Sin 2018 Jan;34(1):66-76
    Division of Cardiology, Department of Internal Medicine.
    Background: Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present with VTE without exhibiting the traditional risk factors. We investigated the relationship between a history of uterine leiomyoma and the risk of VTE using the National Health Insurance Research Database (NHIRD). Read More

    Delayed diagnosis of dermal leiomyosarcoma mimicking keloid scar.
    BMJ Case Rep 2018 Jan 26;2018. Epub 2018 Jan 26.
    Plastic Surgery Unit, The Ulster Hospital, Belfast, UK.
    A 43-year-old man developed an abnormal scar 6 months following excision of a leiomyoma from his left shoulder. The scar was elevated, irregular in shape, pink-red in colour, hard in consistency and it was extending beyond the margins of the original wound. A diagnosis of a keloid scar was considered and the patient was managed as such. Read More

    Karakousis's abdominoinguinal approach for the treatment of a primary retroperitoneal parasitic leiomyoma with inguinal extension. A case report.
    Int J Surg Case Rep 2018 Jan 9. Epub 2018 Jan 9.
    Department of General Surgery and Digestive Diseases, University Hospital of Araba, Vitoria, Spain; University of the Basque Country, UPV, Vitoria, Spain. Electronic address:
    Introduction: Primary retroperitoneal parasitic leiomyoma (PRPL) with inguinal extension is a diagnostic-therapeutic challenge due to its uncertain etiopathogenesis and because it has been considered unresectable according to customary surgical techniques in some instances. The abdominoinguinal incision described by Karakousis in the 1980s allows a safe and radical approach for lower quadrants abdominopelvic tumors.

    Objectives: We present the case of a rare PRPL satisfactorily treated through Karakousis's approach. Read More

    Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
    Pathology 2018 Feb 17;50(2):238-256. Epub 2018 Jan 17.
    University of California San Francisco, Pathology Department, San Francisco, CA, United States. Electronic address:
    The most common hereditary gynaecological tumour syndromes are hereditary breast and ovarian cancer syndrome and Lynch syndrome. However, pathologists also may encounter gynaecological tumours in women with rare hereditary syndromes. Many of these tumours exhibit distinctive gross and microscopic features that are associated with a risk for an inherited gene mutation. Read More

    Is robot-assisted laparoscopic myomectomy limited in multiple myomas?: a feasibility for ten or more myomas.
    Obstet Gynecol Sci 2018 Jan 22;61(1):135-141. Epub 2017 Dec 22.
    Seoul St. Mary's Fibroid Center, Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Objective: To evaluate the feasibility of robot-assisted laparoscopic myomectomy in multiple myomas over 10.

    Methods: A retrospective study was conducted for 662 patients who underwent robot-assisted laparoscopic myomectomy and open myomectomy by a single operator in a tertiary university hospital.

    Results: A total of 30 women underwent removal of 10 or more uterine myomas by robotics and 13 patients were selected for this study. Read More

    The expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor in myoma and adenomyosis.
    Obstet Gynecol Sci 2018 Jan 21;61(1):127-134. Epub 2017 Dec 21.
    Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
    Objective: We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate the possibility of using MIS/anti-Müllerian hormone (AMH) as a biological regulator or therapeutic agent in patients with uterine leiomyoma and adenomyosis.

    Methods: We studied normal uterine myometrium, leiomyoma, endometrial tissue, and adenomyosis from 57 patients who underwent hysterectomy for uterine leiomyoma (22 cases) or adenomyosis (28 cases) and myomectomy for uterine myoma (7 cases). Immunohistochemical staining was used to confirm the MIS/AMHRII protein expression level in each tissue. Read More

    Broad Ligament Lipoleiomyoma Masses: Two curious cases masquerading as ovarian carcinomas.
    Sultan Qaboos Univ Med J 2017 Nov 10;17(4):e477-e480. Epub 2018 Jan 10.
    Department of Obstetrics & Gynaecology, Maulana Azad Medical College, New Delhi, India.
    Lipoleiomyomas are an extremely rare form of uterine leiomyoma; moreover, the occurrence of this type of tumour on the broad ligament is even rarer. We report two cases of broad ligament lipoleiomyomas in 15- and 38-year-old female patients who presented to the Lok Nayak Jai Prakash Hospital in New Delhi, India, between 2016 and 2017. In both cases, the preoperative diagnosis was of a solid ovarian malignancy. Read More

    Comparison of Long-Term Fertility Outcomes after Myomectomy: Relationship with Number of Fibroids Removed.
    J Minim Invasive Gynecol 2018 Jan 22. Epub 2018 Jan 22.
    Department of Obstetrics and Gynecology and Women's Health Institute at the Cleveland Clinic. Electronic address:
    Study Objective: To determine if the number of fibroids removed during myomectomy for symptomatic relief affects long-term fertility outcomes in reproductive aged women.

    Design: Retrospective cohort survey study (Canadian Task Force classification II-2) SETTING: University hospital PATIENTS: One hundred forty-four patients who underwent myomectomy for symptomatic fibroids and attempted to conceive afterwards INTERVENTION: Questionnaire mailed to reproductive-aged women who received robotic, laparoscopic, or abdominal myomectomy MEASUREMENTS AND MAIN RESULTS: Patients with >6 fibroids removed were less likely to achieve pregnancy after myomectomy than patients with ≤6 fibroids removed (22.9% vs 70. Read More

    Laparoscopic approach in the treatment of large leiomyoma of the lower third of the esophagus.
    Wideochir Inne Tech Maloinwazyjne 2017 Dec 29;12(4):437-442. Epub 2017 Dec 29.
    Center of Abdominal Surgery, Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
    Leiomyoma of the lower third of the esophagus is a relatively rare disorder but the most common benign tumor of the esophagus. We present a case of an involuted esophageal leiomyoma, 11 cm in size, treated by the laparoscopic approach. The preoperative computed tomogram visualized a mass 3 × 1. Read More

    Gene expression of human endometrial L-selectin ligand in relation to the phases of the natural menstrual cycle.
    Sci Rep 2018 Jan 23;8(1):1443. Epub 2018 Jan 23.
    Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan City, 32001, Taiwan.
    This study investigates peptide components of L-selectin ligand (LSL) and their gene expressions in human endometrium during the natural menstrual cycle. We recruited 41 endometrial samples from reproductive-aged women with leiomyoma and undergoing hysterectomy and 11 endometrial samples from menopausal women as controls. Immunohistochemistry revealed strong MECA-79 expression from the early through the mid-secretory phase and low expression in menopausal endometrium. Read More

    Leiomyoma in the nasal cavity of a dog.
    J Small Anim Pract 2018 Jan 22. Epub 2018 Jan 22.
    Department of Small Animal Surgery, Veterinary School of Alfort, University of Paris-Est, 94700 Paris, France.
    A 7-year-old, 34-kg, neutered male Labrador retriever was presented with a 1-year history of intermittent sneezing with occasional left-sided epistaxis. CT revealed a mass in the left nasal cavity. Histopathological analysis of rhinoscopy-guided tissue biopsies was consistent with chronic necrotic and ulcerative rhinitis. Read More

    The need for further surgical intervention following primary hysteroscopic morcellation of submucosal leiomyomas in women with abnormal uterine bleeding.
    Aust N Z J Obstet Gynaecol 2018 Jan 22. Epub 2018 Jan 22.
    School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
    Background: Intrauterine hysteroscopic morcellators have been studied as an alternative method for removing submucosal leiomyomas.

    Aims: To assess the long-term efficacy of hysteroscopic morcellation of submucosal leiomyomas in women with abnormal uterine bleeding (AUB).

    Materials And Methods: We conducted a prospective cohort study including all women with AUB who underwent a hysteroscopic resection with mechanical morcellation of a benign submucosal leiomyoma confirmed at histopathology. Read More

    Inguinal pain and fullness due to an intravascular leiomyoma in the external iliac vein.
    J Vasc Surg Cases Innov Tech 2017 Jun 24;3(2):102-104. Epub 2017 May 24.
    Division of Vascular and Endovascular Surgery, Department of Surgery, Health Sciences Center T19-090, Stony Brook Medicine, Stony Brook, NY.
    Intravascular leiomyomatosis (IVL) is a benign smooth muscle tumor that evolves from the pelvic veins and can spread to the central veins and heart. Cardiac involvement is the most commonly reported presentation. Initial diagnosis is difficult, and IVL is commonly misdiagnosed as thrombus or atrial myxoma. Read More

    Inhibition of WNT/β-catenin signaling under serum starvation and hypoxia induces adipocytic transdifferentiation in human leiomyoma cells.
    Lab Invest 2018 Jan 18. Epub 2018 Jan 18.
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
    Fatty metamorphosis is an uncommon alteration in uterine leiomyoma (i.e., lipoleiomyoma), and the pathogenetic mechanisms underlying this phenomenon remain poorly understood. Read More

    Esophageal leiomyoma in a dog causing esophageal distension and treated by transcardial placement of a self-expanding, covered, nitinol esophageal stent.
    J Am Vet Med Assoc 2018 Feb;252(3):330-335
    CASE DESCRIPTION A 10-year-old spayed female Rottweiler was referred for evaluation because of a 2-month history of regurgitation and weight loss, despite no apparent change in appetite. The dog had received antiemetic and antacid treatment, without improvement. CLINICAL FINDINGS Physical examination revealed a low body condition score (2/5), but other findings were unremarkable. Read More

    Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body.
    Ocul Oncol Pathol 2017 Nov 21;3(4):304-309. Epub 2017 Apr 21.
    Yale New Haven Hospital, New Haven, Connecticut, USA.
    Purpose: We report a case of acutely presenting mesectodermal leiomyoma of the ciliary body in a 29-year-old female who reported waking up with swollen eyelids of the right eye and light-perception vision. The affected eye had elevated intraocular pressure, a flat anterior chamber, and a pale, round mass arising from the nasal ciliary body, invading the angle and protruding into the visual axis posterior to the lens. Within days, the visual acuity decreased to no light perception. Read More

    Ring-Shaped Leiomyoma of the Ciliary Body.
    Ocul Oncol Pathol 2017 Nov 24;3(4):250-253. Epub 2017 Mar 24.
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
    Purpose: Ciliary body mesectodermal leiomyoma is a rare, benign smooth muscle tumor that typically presents in women in the second to fourth decade of life. The diagnosis is typically based on clinical color, funduscopic appearance, transillumination properties, and B-scan ultrasonography.

    Methods: We present a patient with a 360° ciliary body mass with transillumination and ultrasonographic properties consistent with a ring melanoma. Read More

    Successful operative treatment of uterine leiomyoma with extensive intravenous extension to the IVC, right heart, and pulmonary arteries.
    Acta Chir Belg 2018 Jan 17:1-4. Epub 2018 Jan 17.
    d Royal Sussex County Hospital , Sussex , UK.
    Introduction: Intravenous extension of benign uterine leiomyomata ('fibroids'), in the absence of discrete metastatic disease has rarely been reported. 'Fibroids' remain one of the most common premenopausal uterine pathologies.

    Methods And Results: We report the diagnosis and multidisciplinary led operative management of a 52-year-old woman with a histologically benign, but biologically aggressive, uterine leiomyoma with intravenous extension to the inferior vena cava (IVC), right heart and pulmonary arteries. Read More

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