Histopathology 2017 Aug 18. Epub 2017 Aug 18.
Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, No.20, Yuhuangding East Road, Yantai, 264000, China.
High molecular weight caldesmon (H-caldesmon) is the protein that binds to actin and tropomyosin regulating smooth muscle contraction function.(1) It is mainly expressed in smooth muscle cells and the research data showed the specificity of smooth muscle is higher than that of desmin and actin.(2) In clinical diagnosis, H-caldesmon can be used to identify myofibroblastic tumors from true leiomyoma and to differentiate uterine smooth muscle tumors from endometrial stromal sarcoma combined with CD10. Read More