22,303 results match your criteria Leiomyoma


Ultrasound-Guided Transcervical Ablation of Uterine Leiomyomas.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Stamford Hospital, Stamford, Connecticut; Magee-Women's Hospital, Pittsburgh, Pennsylvania; Arizona Gynecology Consultants, Phoenix, Arizona; Mercy Hospital, St. Louis, Missouri; Virginia Mason Medical Center, Seattle, Washington; and Hospital Universitario "Dr. José Eleuterio González" de Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.

Objective: To evaluate the 12-month safety and effectiveness of transcervical ablation for the treatment of symptomatic uterine leiomyomas.

Methods: In this prospective, multicenter, single-arm interventional trial, transcervical ablation was performed on 1-10 leiomyomas per patient with leiomyoma diameters ranging from 1 to 5 cm. Treated leiomyomas included all nonpedunculated types. Read More

View Article
December 2018

Vilaprisan in women with uterine fibroids: the randomized phase 2b ASTEROID 1 study.

Fertil Steril 2018 Dec 6. Epub 2018 Dec 6.

Bayer, Berlin, Germany.

Objectives: To assess the safety and efficacy of four vilaprisan doses (0.5-4.0 mg) in women with uterine fibroids. Read More

View Article
December 2018

Five-year clinical outcomes of uterine artery embolization for symptomatic leiomyomas: An analysis of risk factors for reintervention.

Eur J Radiol 2018 Dec 28;109:83-87. Epub 2018 Oct 28.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Republic of Korea.

Objectives: The objective of this study is to investigate the five-year reintervention rate of uterine artery embolization (UAE) for symptomatic leiomyomas and to identify potential predictive factors of reintervention.

Methods: From March 2011 to February 2012, 92 consecutive women (mean age 41.9 years, range 28-55 years) underwent bilateral UAE. Read More

View Article
December 2018

[Magnetic resonance imaging findings and differential diagnosis of renal epithelioid angiomyolipoma comparing with renal no-epithelioid angiomyolipoma].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3701-3704

Department of X-ray, the Affiliated Chinese Medical Hospital of Southwest Medical University, Luzhou 646300, China.

To investigate whether MRI findings can differentiate renal epithelioid angiomyolipoma (EAML) from renal no-epithelioid (typical) angiomyolipoma. A total of 44 patients were collected from General Hospital of PLA.These cases were obtained from January 2009 to June 2015. Read More

View Article
December 2018

Identification of uterine telocytes and their architecture in leiomyoma.

Folia Med Cracov 2018 ;58(3):89-102

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More

View Article
January 2018
1 Read

Malignant transformation of adenomyosis: literature review and meta-analysis.

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.

Purpose: To review and analyze risk factors and the pathology of malignant transformation of adenomyosis.

Methods: In this paper, the relevant research on current risks factors and the pathology of malignant transformation of adenomyosis was reviewed and analyzed by metaanalysis. All studies included were retrieved from the PUBMED. Read More

View Article
December 2018

The Role of Tumor Necrosis Factor α in the Biology of Uterine Fibroids and the Related Symptoms.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

First Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-004 Warsaw, Poland.

Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. The incidence of UFs has been estimated at 25⁻80% depending on selected population. The pathophysiology of UFs remains poorly understood. Read More

View Article
December 2018
2 Reads

A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review.

Clin Med Insights Oncol 2018 26;12:1179554918813535. Epub 2018 Nov 26.

Department of Pathology, Wanbei Coal-Electricity Group General Hospital, Suzhou, China.

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Read More

View Article
November 2018

Simvastatin, at clinically relevant concentrations, affects human uterine leiomyoma growth and extracellular matrix production.

Fertil Steril 2018 Dec;110(7):1398-1407.e1

Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Electronic address:

Objective: To observe the antifibroid effects of therapeutic concentrations of simvastatin, which interferes with cholesterol biosynthesis, a known precursor of five major classes of steroid hormones, including progesterone and estrogen, which play a major role in the development and growth of uterine leiomyomas.

Design: Two-dimensional and three-dimensional cell culture study of immortalized human leiomyoma and patient-matched myometrium cells treated with simvastatin.

Setting: University laboratory. Read More

View Article
December 2018

Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases.

J Comp Pathol 2018 Nov 19;165:13-22. Epub 2018 Oct 19.

Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertagstrase 15, Germany. Electronic address:

Disorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 full post-mortem examinations of intact female pet guinea pigs and 64 female genital tract biopsies examined over a 22. Read More

View Article
November 2018

A case of atypically located leiomyoma mimicking axillary lymphadenomegaly.

Turk J Pediatr 2018 ;60(3):319-321

Departments of Pathology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

Cevizci MN, Fettah A, Kabalar ME. A case of atypically located leiomyoma mimicking axillary lymphadenomegaly. Turk J Pediatr 2018; 60: 319-321. Read More

View Article
January 2018

Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology.

Case Rep Obstet Gynecol 2018 30;2018:5067276. Epub 2018 Oct 30.

Department of Gynecology, Francisco Gentil Portuguese Oncology Institute, Porto, Portugal.

Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Read More

View Article
October 2018

Comparing perioperative vaginal misoprostol to intraoperative pericervical hemostatic tourniquet in reducing blood loss during abdominal myomectomy: a randomized controlled trial

J Turk Ger Gynecol Assoc 2018 Nov 30. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

Objective: To compare the effectiveness of perioperative vaginal misoprostol to intraoperative pericervical hemostatic tourniquet in reducing blood loss during abdominal myomectomy.

Material And Methods: A randomized controlled trial involving women with uterine leiomyoma who underwent abdominal myomectomy at a tertiary facility in Nigeria. Participants were recruited after informed consent and randomized into Group I (single dose 400 µg vaginal misoprostol one-hour before surgery) and Group II (intraoperative pericervical hemostatic tourniquet). Read More

View Article
November 2018

[Uterine leiomyoma and fumarate hydratase deficiency].

Gynecol Obstet Fertil Senol 2018 Nov 26. Epub 2018 Nov 26.

Service de gynécologie et obstétrique et médecine de la reproduction, faculté de Médecine Pierre et Marie-Curie, hôpital Tenon, Sorbonne université, Assistance publique des Hôpitaux de Paris (AP-HP), 4, rue de La Chine, 75020 Paris, France; Groupe de recherche clinique 6 (GRC6-UPMC), Centre Expert En Endométriose (C3E), hôpital Tenon, assistance publique des hôpitaux de Paris (AP-HP), 4 rue de La Chine, 75020 Paris, France; UMR_S938 Sorbonne université, 75020 Paris, France.

View Article
November 2018

Low-grade endometrial stromal sarcoma combined with leiomyoma (stromomyoma): A bizarre tumor of the uterus in a premenopausal woman.

J Exp Ther Oncol 2018 Nov;12(4):281-286

University of Health Sciences, Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Ankara, Turkey.

Objective: Uterine sarcomas are very rare malignancies, and when a hysterectomy is performed for benign causes, a risk of about 1/500 is mentioned for possible uterine sarcomas. Endometrial stromal neoplasms are a rare subgroup of uterine sarcomas that account for less than 10% of all uterine sarcomas. Mixed endometrial stromal and smooth muscle tumors, also known as stromomyomas, are defined as having at least 30% each of endometrial stromal and smooth muscle components. Read More

View Article
November 2018
2 Reads

A multiparametric MRI-based machine learning to distinguish between uterine sarcoma and benign leiomyoma: comparison with F-FDG PET/CT.

Clin Radiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Tyuou-ku, Kumamoto, 860-0811, Japan.

Aim: To compare the performance of machine learning using multiparametric magnetic resonance imaging (mp-MRI) and positron-emission tomography (PET) to distinguish between uterine sarcoma and leiomyoma.

Materials And Methods: This retrospective study was approved by the institutional review board and informed consent was waived. Sixty-seven consecutive patients with uterine sarcoma or leiomyoma who underwent pelvic 3 T MRI and PET were included. Read More

View Article
November 2018
3 Reads

Neoplasm of a supernumerary undescended testis: A case report and review of the literature.

Int J Surg Case Rep 2018 Nov 13;53:345-347. Epub 2018 Nov 13.

Urology Department, Ibn El Jazzar Teaching Hospital, Kairouan, Tunisia.

Introduction: Polyorchidism, defined as the presence of more than two testicles, is a rare congenital abnormality of the male genital tract. There is no consensus regarding the management of supranumerary testis (SNT) due to its rareness. To the best of our knowledge, this is the first report of leiomyoma in SNT. Read More

View Article
November 2018

A Patient Registry for the Management of Uterine Fibroids in Canada: Protocol for a Multicenter, Prospective, Noninterventional Study.

JMIR Res Protoc 2018 Nov 20;7(11):e10926. Epub 2018 Nov 20.

Department of Obstetrics, Gynecology and Newborn Care, Ottawa Hospital Research Institute, The University of Ottawa, Ottawa, ON, Canada.

Background: Uterine fibroids are the most common benign tumor in women. Among those with fibroids, approximately 30% become symptomatic, with abnormal uterine bleeding, pelvic pain, and bulk symptoms. Despite the high prevalence of fibroids, little information is available regarding symptoms, treatment choices, and outcomes for patients. Read More

View Article
November 2018
1 Read

Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/β-catenin pathway.

Fertil Steril 2018 Nov 17. Epub 2018 Nov 17.

Fundación IVI, Instituto Universitario IVI, Universidad de Valencia, Valencia, Spain; Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: To assess the effect of vitamin D (VitD) on human uterine leiomyomas through Wnt/β-catenin pathway inhibition, apoptosis induction, and cell growth arrest.

Design: A prospective study comparing leiomyoma vs. myometrium tissues. Read More

View Article
November 2018
3 Reads

Ocular Surface Leiomyoma in a Child after Strabismus Repair.

Ophthalmology 2018 Dec;125(12):1968

Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York.

View Article
December 2018
2 Reads

Phthalates exposure and uterine fibroid burden among women undergoing surgical treatment for fibroids: a preliminary study.

Fertil Steril 2018 Nov 12. Epub 2018 Nov 12.

Department of Obstetrics and Gynecology, The George Washington University, Washington, DC.

Objectives: To examine the association between phthalate exposure and two measures of uterine fibroid burden: diameter of largest fibroid and uterine volume.

Design: Pilot, cross-sectional study.

Setting: Academic medical center. Read More

View Article
November 2018
4 Reads

Recognizing Hereditary Renal Cancers Through the Microscope: A Pathology Update.

Surg Pathol Clin 2018 Dec 17;11(4):725-737. Epub 2018 Oct 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

A heightened understanding of hereditary renal cancer syndromes and their molecular basis has led to an increased awareness and recognition of these renal neoplasms by pathologists. Because a diagnosis of hereditary renal cell carcinoma has a profound impact on the patient and family members, when and how to raise such a suspicion via pathologic assessment has become an important yet very challenging task. This review discusses key clinicopathologic, immunohistochemical, and genetic characteristics of hereditary renal cancer syndromes, and important differential diagnostic challenges, emphasizing recent pathologic and molecular advances. Read More

View Article
December 2018
4 Reads

Point-of-care Ultrasonography of a Rare Cause of Hemoperitoneum.

Clin Pract Cases Emerg Med 2018 Nov 5;2(4):320-322. Epub 2018 Sep 5.

SUNY Downstate Medical Center, Department of Emergency Medicine, Brooklyn, New York.

A young woman presented to the emergency department with lethargy, hemodynamic instability, and diffuse abdominal tenderness. On point-of-care ultrasound (PoCUS), she was found to have intraperitoneal free fluid and a large pelvic mass, which were discovered intraoperatively to be hemoperitoneum due to ruptured vessels of a uterine leiomyoma. Although rare, a life-threatening, ruptured leiomyoma may be treated surgically if recognized in an expedient fashion. Read More

View Article
November 2018

Port site parasitic leiomyoma after laparoscopic myomectomy: a case report and review of the literature.

J Med Case Rep 2018 Nov 15;12(1):339. Epub 2018 Nov 15.

Department of Obstetrics and Gynaecology, Aga Khan University, P.O. Box 30270-00100, Nairobi, Kenya.

Background: Uterine fibroids are the commonest benign gynecological tumors. Laparoscopic myomectomy is becoming increasingly popular as one of the surgical treatment options for symptomatic cases. Large tissues such as leiomyomas or even the uterus need to be morcellated in order to be retrieved from the abdominal cavity. Read More

View Article
November 2018
4 Reads

Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas.

Cancer 2018 Nov 13. Epub 2018 Nov 13.

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.

Background: Uterine leiomyomas (ULs) are the most common gynecologic tumors and affect 3 of every 4 women by the age of 50 years. The majority of ULs are classified as conventional tumors, whereas 10% represent various histopathological subtypes with features that mimic malignancy. These subtypes include cellular and mitotically active ULs and ULs with bizarre nuclei. Read More

View Article
November 2018
5 Reads

Safety and feasibility of contained uterine morcellation in women undergoing laparoscopic hysterectomy.

Gynecol Oncol Res Pract 2018 30;5. Epub 2018 Oct 30.

3Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710 USA.

Background: Widespread concerns have been raised regarding the safety of power morcellation of uterine specimens because of the potential to disseminate occult malignancy. We sought to assess the safety and feasibility of contained manual uterine morcellation within a plastic specimen bag among women with uterine neoplasms.

Methods: A retrospective single-institution descriptive cohort study was conducted from 2003 to 2014. Read More

View Article
October 2018
8 Reads

Spontaneous complete regression of large uterine fibroid after the second vaginal delivery: Case report.

Authors:
Myounghwan Kim

Medicine (Baltimore) 2018 Nov;97(45):e13092

Rationale: Fibroids are common, hormone-dependent, benign uterine tumors. It is estimated that they occur in 20% to 40% of women during their reproductive years. The prevalence of fibroids among pregnant women is 10. Read More

View Article
November 2018
4 Reads

Predicting Malignancy Risk in Gastrointestinal Subepithelial Tumors with Contrast-Enhanced Harmonic Endoscopic Ultrasonography Using Perfusion Analysis Software.

Gut Liver 2018 Oct 18. Epub 2018 Oct 18.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

Background/aims: Contrast-enhanced harmonic endoscopic ultrasonography (CEH-EUS) is a promising imaging modality that can differentiate subepithelial tumors (SETs) by detecting the degree of enhancement. However, whether CEH-EUS alone can predict the malignancy risk of gastrointestinal stromal tumors (GISTs) remains unclear. This study aimed to evaluate the feasibility of CEH-EUS by using perfusion analysis software for distinguishing among SETs and predicting the malignancy risk of GISTs. Read More

View Article
October 2018
5 Reads

Diagnosis and Management of an Adenomatoid Uterine Tumor: Ultrasound, Magnetic Resonance Imaging, Surgical Appearance, and Pathology Correlation.

Biores Open Access 2018 26;7(1):159-164. Epub 2018 Oct 26.

Department of Obstetrics and Gynecology and Texas Tech University Health Sciences Center, Lubbock, Texas.

Adenomatoid uterine tumors are rare, and their appearance on medical imaging modalities is not well established. We present a case of an adenomatoid uterine tumor reviewing a unique sonographic presentation, magnetic resonance imaging (MRI), gross surgical appearance of the tumor, and microscopic pathology images. A 29-year-old gravida 0 Caucasian woman presented with dysmenorrhea, menorrhagia, and desire to conceive. Read More

View Article
October 2018
2 Reads

MR Imaging of a Leiomyosarcoma Arising in Leiomyoma.

Magn Reson Med Sci 2018 Nov 2. Epub 2018 Nov 2.

Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University.

View Article
November 2018

Clinical anatomy of pelvic pain in women: A Gynecological Perspective.

Clin Anat 2018 Nov 2. Epub 2018 Nov 2.

Department of Anatomical Sciences, St. George's University, St. George's, Grenada, West Indies.

Pelvic pain is a common symptom that affects women worldwide and usually presents with variable range of severity, duration, and location. Several gynecological conditions may result in pelvic pain, and may have a variable presentation among patients. Pelvic pain creates a significant challenge and frustration to both patients and clinicians, which also creates a significant burden on the economy. Read More

View Article
November 2018
1 Read

Analysis of estrogen and progesterone receptor gene polymorphisms in leiomyoma.

J Clin Lab Anal 2018 Nov 2:e22704. Epub 2018 Nov 2.

Faculty of Medicine, Department of Obstetrics and Gynecology, Gaziosmanpasa University, Tokat, Turkey.

Background: Leiomyoma, one of the most common benign tumors, causes morbidity during the reproductive years in women. The molecular pathogenesis of the disease is not clear. Leiomyomas are hormone-sensitive tumors affecting around 20%-25% of women. Read More

View Article
November 2018

Endoscopic Enucleation Is Effective and Relatively Safe in Small Gastric Subepithelial Tumors Originating from Muscularis Propria.

Dig Dis Sci 2018 Nov 3. Epub 2018 Nov 3.

Division of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Inha University Hospital, 27, Inhang-ro, Jung-Gu, Incheon, 22332, Republic of Korea.

Background: Gastric subepithelial tumors originating from muscularis propria (MP) are usually benign, but some have malignant potential.

Aims: The aim of this study was to evaluate the utility of endoscopic enucleation for the diagnosis and treatment of MP tumors.

Patients And Methods: From January 2010 to February 2018, eighty patients with gastric MP tumors underwent endoscopic enucleation at our hospital. Read More

View Article
November 2018
4 Reads

Retroperitoneoscopic partial nephrectomy for renal cell carcinoma: A single-center Indian experience.

Urol Ann 2018 Oct-Dec;10(4):400-405

Department of Urology and Transplantation Surgery, Institute of Kidney Disease and Research Centre, Dr. H.L. Trivedi Institute of Transplant Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.

Objective: Retroperitoneoscopy, by avoiding peritoneal breach and injury to intra-abdominal organs, provides a more direct and rapid access to the kidney and the renal hilum. Laparoscopic partial nephrectomy by retroperitoneal route (LPNR) is less commonly performed than transperitoneal route for early stage renal cancer. The objective of this study is to carry out the outcomes of partial nephrectomy using retroperitoneal approach. Read More

View Article
November 2018
3 Reads

Comparison of 30-day Complication Rates between Laparoscopic Myomectomy and Total Laparoscopic Hysterectomy for the Treatment of Uterine Leiomyoma in Women Older Than Age 40.

J Minim Invasive Gynecol 2018 Oct 29. Epub 2018 Oct 29.

Section of Urogynecology and Reconstructive Pelvic Surgery, Obstetrics, Gynecology & Women's Health Institute, Cleveland Clinic, Cleveland, Ohio (Drs. Bretschnieder, Billow, and Ninivaggio).

Study Objective: To evaluate whether there are differences in complication rates between laparoscopic myomectomy (LM) and total laparoscopic hysterectomy (TLH) for the treatment of uterine leiomyoma in perimenopausal women.

Design: A retrospective cohort study using 1:2 propensity score matching (Canadian Task Force classification II-2).

Setting: American College of Surgeons National Surgical Quality Improvement Program database. Read More

View Article
October 2018
1 Read

The Effectiveness of Tranexamic Acid at Reducing Blood Loss and Transfusion Requirement for Women Undergoing Myomectomy: A Systematic Review and Meta-analysis.

J Obstet Gynaecol Can 2018 Oct 29. Epub 2018 Oct 29.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON. Electronic address:

Background: The surgical removal of fibroids can be associated with excessive blood loss requiring transfusion.

Objective: This review sought to determine the effectiveness of tranexamic acid (TA) in reducing perioperative blood loss in women undergoing myomectomy.

Methods: Electronic bibliographic databases were searched from inception until June 3, 2017. Read More

View Article
October 2018
1 Read

Prediction of the operative time for hysteroscopic myomectomy for leiomyomas penetrating the intramural cavity using leiomyoma weight and clinical characteristics of patients.

Reprod Med Biol 2018 Oct 30;17(4):487-492. Epub 2018 Sep 30.

Department of Obstetrics and Gynecology, Graduate School of Medicine The University of Tokyo Tokyo Japan.

Purpose: To preoperatively predict the operative time (OT) for hysteroscopic myomectomy for G1 or G2 leiomyoma based on leiomyoma weight.

Methods: The data from 544 patients who underwent one-step hysteroscopic myomectomy were analyzed retrospectively. A total of 340 patients with leiomyoma penetrating the intramural cavity were identified as suitable candidates for calculation of the OT based on leiomyoma weight; we considered leiomyoma weight to be the most objective parameter for evaluating leiomyoma tissues. Read More

View Article
October 2018

MicroRNAs involved in the HMGA2 deregulation and its co-occurrence with MED12 mutation in uterine leiomyoma.

Mol Hum Reprod 2018 Nov;24(11):556-563

Department of Clinical Genetics, Vejle Hospital, Institute of Regional Health Research, University of Southern Denmark, DK, Denmark.

Study Question: Can the mediator complex subunit 12 (MED12) mutation and high mobility group AT-hook 2 (HMGA2) overexpression co-occurrence be explained by the alternative mechanism of HMGA2 dysregulation in uterine leiomyomas (UL)?

Summary Answer: The co-occurrence of MED12 mutation and HMGA2 overexpression, and a negative correlation of five validated or predicted microRNAs that target HMGA2 were reported.

What Is Known Already: The recent stratification of UL, according to recurrent and mutually exclusive genomic alterations affecting HMGA2, MED12, fumarate hydratase (FH) and collagen type IV alpha 5-alpha 6 (COL4A5-COL4A6) pointed out the involvement of distinct molecular pathways. However, the mechanisms of regulation involving these drivers are poorly explored. Read More

View Article
November 2018
4 Reads

Leiomyoma of the Retzius space in a male patient: A case report and a diagnostic approach to Retzius space diseases.

J Clin Ultrasound 2018 Oct 29. Epub 2018 Oct 29.

1st department of Radiology, "Aretaieion" University Hospital, National & Kapodistrian University of Athens, Athens, Greece.

Retzius space is a small anatomical compartment located directly posterior to the pubic symphysis and anterior to the urinary bladder. Diseases developing primarily in this space are rare; only 7 cases of leiomyomas of the Retzius space have been reported in the literature so far, all of them in female patients. We present a unique case of a leiomyoma of the Retzius space in a male patient. Read More

View Article
October 2018
3 Reads

Use of pre-operative imaging for symptomatic uterine myomas during pregnancy: a case report and a systematic literature review.

Arch Gynecol Obstet 2018 Oct 29. Epub 2018 Oct 29.

Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia, 78-95029, Catania, Italy.

Purpose: Uterine fibroids (UFs) occur in 10% of pregnancies and may lead to severe maternal-fetal complications, mainly depending on UFs characteristics and the distance to the uterine cavity (UC). When symptomatic, UFs are managed medically. Nevertheless, in about 2% of cases, surgery becomes necessary. Read More

View Article
October 2018
1 Read

Development and rapid growth of retroperitoneal leiomyoma during carboplatin/paclitaxel chemotherapy in an ovarian cancer patient.

Authors:
Isao Otsuka

Eur J Obstet Gynecol Reprod Biol 2018 Dec 19;231:282-283. Epub 2018 Oct 19.

Department of Obstetrics and Gynecology, Kameda Medical Center, 929 Higaschi-cho, Kamogawa, Chiba, Japan. Electronic address:

View Article
December 2018
3 Reads

Cystic degeneration of hepatic adenoma: a rare complication of hepatic adenoma.

BJR Case Rep 2018 17;4(1):20170056. Epub 2017 Nov 17.

Glasgow Royal Infirmary, Glasgow, Scotland.

This case report describes a rare complication of hepatic adenomata in a 33-year-old female. The patient initially presented with abdominal pain, and baseline imaging demonstrated several hepatic adenomas, the largest of which (approximately 8 cm) was adjacent to the inferior vena cava. Owing to the location of this adenoma, surgical/vascular intervention was deemed inappropriate. Read More

View Article
November 2017
6 Reads

Not so benign.

Authors:
Barbara Rivera

Elife 2018 10 26;7. Epub 2018 Oct 26.

Gerald Bronfman Department of Oncology, McGill University, Montreal, Canada.

Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development. Read More

View Article
October 2018
1 Read

Uterine Leiomyosarcoma: Can MRI Differentiate Leiomyosarcoma From Benign Leiomyoma Before Treatment?

AJR Am J Roentgenol 2018 Dec 24;211(6):1405-1415. Epub 2018 Oct 24.

1 MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington DC 20007.

Objective: The purpose of this article is to provide background on the epidemiologic, clinical, and economic impact of uterine leiomyomas, summarize the concerns associated with treating women with potential occult leiomyosarcomas (LMSs), and review the known and emerging imaging features of typical and atypical leiomyomas and explain how to differentiate them from LMSs.

Conclusion: Surgical management of presumed benign uterine leiomyomas received popular media attention when a case of disseminated LMS occurred after laparoscopic power morcellator-assisted hysterectomy. A subsequent U. Read More

View Article
December 2018
2 Reads

Occult Leiomyosarcomas in a Canadian Province: A Retrospective Cohort Study.

J Obstet Gynaecol Can 2018 Oct 16. Epub 2018 Oct 16.

Department of Obstetrics and Gynecology, University of Saskatchewan, Regina & Saskatoon, SK. Electronic address:

Objective: The risk of unexpected uterine leiomyosarcoma (LMS) following surgery for presumed benign leiomyoma is quoted to be between 1 in 498 and 1 in 5000. The objectives of the present study were to determine the prevalence of uterine LMS in a specific patient population and the rate of diagnosis of occult uterine LMS and to evaluate the risk of unintended morcellation of LMS in Saskatchewan.

Methods: This study was a Canadian Task Force Classification II-2 multicentre retrospective cohort study in academic-affiliated tertiary care centres. Read More

View Article
October 2018
1 Read

Increased LDH5/LDH1 ratio in preoperative diagnosis of uterine sarcoma with inconclusive MRI and LDH total activity but suggestive CT scan: a case report.

BMC Womens Health 2018 Oct 19;18(1):169. Epub 2018 Oct 19.

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.

Background: Morcellation of undiagnosed uterine sarcoma is cause of abdominal/pelvic dissemination, residual tumor and recurrence. In the preoperative evaluation of suspect uterine masses, magnetic resonance imaging (MRI) and serum lactate dehydrogenase (LDH) total activity are referred to as the most effective tools, while computed tomography scan (CT) and LDH isoenzymes are less considered in literature.

Case Presentation: A 46 year old woman was admitted to our department with a large uterine mass. Read More

View Article
October 2018
5 Reads
1.660 Impact Factor

Methotrexate (MTX)-associated malignant lymphoma of the bilateral breast: imaging features in comparison to other nipple-areolar tumors.

Clin Imaging 2019 Jan - Feb;53:120-125. Epub 2018 Oct 6.

Department of Pathology, National Hospital Organization Kyushu Medical Center, Japan.

Tumors originating from the nipple-areolar complex of the breast are rare. We herein report the case of a patient with metachronous bilateral areolar methotrexate (MTX)-associated lymphoma. The patient was a 67-year-old woman who presented with a rapidly enlarging tumor in the areolar region of her left breast. Read More

View Article
October 2018
6 Reads

[Growth mechanisms and morphological structural features of large uterine leiomyoma].

Arkh Patol 2018 ;80(5):16-22

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the growth mechanisms of large uterine leiomyoma (LULM) on the basis of a clinical morphology examination, by providing immunohistochemical (IHC) characteristics of the expression of growth factors (transforming growth factor-beta (TGFβ) and platelet-derived endothelial cell growth factor (PD-ECGF)) and markers of stemness (CD117/c-kit, Connexin 43, Nestin) and proliferation (Ki-67).

Subject And Methods: The investigators examined surgical specimens from 38 women diagnosed with simple uterine leiomyoma (ULM), who had been divided into two groups: 1) 21 patients with LULM (>6 cm in diameter) (a study group); 2) 17 patients with small ULM (<4 cm in diameter) (a comparison group). Each group was also divided into two age subgroups (younger (<45 years) and older (≥45 years) subgroups (1a (n=12), 1b (n=9), 2a (n=8) and 2b (n=9), respectively. Read More

View Article
January 2018

Paraspinal Leiomyoma.

Pediatr Dev Pathol 2018 Oct 17:1093526618808723. Epub 2018 Oct 17.

1 Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

View Article
October 2018
2 Reads

[Myoma with an intra-abdominal bleeding].

Ugeskr Laeger 2018 Oct;180(41)

I this case report a 37-year-old nulliparous woman was admitted for acute onset of abdominal pain. CT scan showed a homogeneous tumour related to the internal genitalia and extravasation of contrast material, but the site of bleeding was not identifiable. Ultrasonography revealed leiomyoma and haemoperitoneum, and emergency laparoscopy was performed. Read More

View Article
October 2018
3 Reads