Search our Database of Scientific Publications and Authors

I’m looking for a

    21213 results match your criteria Leiomyoma

    1 OF 425

    Radio-surgical and pathologic correlations of pelvic intravenous leiomyomatosis.
    Abdom Radiol (NY) 2017 Jun 22. Epub 2017 Jun 22.
    Department of Gynecology, Institute Paoli-Calmettes, Marseille, France.
    Intravenous leiomyomatosis has an unusual growth pattern characterized by proliferation of smooth muscle in uterine and systemic veins. Although histologically benign, this condition could eventually have a clinically aggressive course. At an early stage, the disease is often misdiagnosed on preoperative imaging because of its low prevalence, non-specific initial clinical manifestation, and poorly known radiological characteristics. Read More

    Uterine Artery Embolization and Surgical Methods for the Treatment of Symptomatic Uterine Leiomyomas: A Systemic Review and Meta-Analysis Followed by Indirect Treatment Comparison.
    Clin Ther 2017 Jun 19. Epub 2017 Jun 19.
    Department of Gynecology, Federal University of Sao Paulo, São Paulo, Brazil.
    Purpose: There is significant discussion and uncertainty about the optimal management of symptomatic uterine leiomyomas (SULs). Nonsurgical procedures such as uterine artery embolization (UAE) have been developed. The goal of this study was to conduct a meta-analysis and an indirect treatment comparison to examine the comparative efficacy and safety of the surgical procedures to treat SULs compared with UAE. Read More

    Endotracheal Leiomyoma Mimicking Malignancy on 18F-FDG PET/CT in a Patient With Papillary Thyroid Carcinoma.
    Clin Nucl Med 2017 Jun 20. Epub 2017 Jun 20.
    From the Departments of *Nuclear Medicine, †Otorhinolaryngology, and ‡Pathology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
    Endotracheal leiomyoma is a rare benign lesion, accounting for approximately 1% of tracheal tumors, and generally occurs in the lower respiratory tract. Because its growth causes airway obstruction symptom, surgical treatment is generally suggested after detection. We report a case with leiomyoma of the cervical endotracheal space showing intense FDG uptake on F-FDG PET/CT mimicking malignancy in a 79-year-old woman with papillary thyroid carcinoma. Read More

    First Versus Second Uterine Artery Embolization for Symptomatic Leiomyoma.
    AJR Am J Roentgenol 2017 Jun 22:1-6. Epub 2017 Jun 22.
    1 Department of Radiology, Saiseikai Shiga Hospital, Ohashi 2-4-1, Ritto, Shiga, 520-3046, Japan.
    Objective: The purpose of this study was to compare the outcomes of second uterine artery embolization (UAE) with those of first UAE for symptomatic uterine leiomyoma.

    Materials And Methods: In this single-institution retrospective study, between December 1997 and May 2016 first UAE was performed on 423 consecutively registered patients and second UAE on 11 consecutively registered patients to treat leiomyoma. The primary endpoint was infarction of all tumor tissue as seen at postprocedural contrast-enhanced MRI. Read More

    A Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas.
    J Clin Endocrinol Metab 2017 Jun 14. Epub 2017 Jun 14.
    Department of Obstetrics & Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.
    Context: Despite progesterone's key role in uterine smooth muscle tumorigenesis, the mechanisms by which it promotes the growth of uterine leiomyomas remain poorly understood.

    Objective: The aim of this study was to identify novel gene products mediating progesterone's effects in uterine leiomyomas.

    Design: Gene expression profiling was used to identify putative progesterone-regulated genes differentially expressed in uterine leiomyomas, which were then studied in vitro. Read More

    Fibroblastic connective tissue nevus: Clinicopathological and immunohistochemical study of 14 cases.
    J Cutan Pathol 2017 Jun 20. Epub 2017 Jun 20.
    Dermatopathology, Bodensee, Siemensstrasse 6/1, 88048, Friedrichshafen, Germany.
    Background: We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labelled as fibroblastic connective tissue nevus (FCTN).

    Methods And Results: Eight patients were male and five were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Read More

    [The molecular mechanisms and morphological manifestations of leiomyoma reduction induced by selective progesterone receptor modulators].
    Arkh Patol 2017 ;79(3):19-26
    Academician V.I. Kulakov Research Centre of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia.
    Aim: to investigate the molecular mechanisms and morphological substrate of reduced uterine leiomyoma in patients receiving the selective progesterone receptor modulator (SPRM) ulipristal acetate for 3 months, by estimating the immunohistochemical expression of the markers steroid receptor coactivator 1 (SRC-1), nuclear receptor corepressor 1 (NCoR-1), ER, PgR, Ki-67, p16, TGF-β, and VEGF in tumor tissue.

    Subjects And Methods: The investigation enrolled 75 women with uterine leiomyoma, menorrhagias, and anemia. Group 1 included 40 patients who were treated with ulipristal for 3 months, followed by laparoscopic myomectomy. Read More

    Clinical characteristics and prognostic features of intravenous leiomyomatosis with inferior vena cava or intracardiac extension.
    J Vasc Surg Venous Lymphat Disord 2017 Jul 21;5(4):485-492. Epub 2017 Apr 21.
    Department of Vascular Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
    Objective: The aim of this study was to explore the clinical characteristics and prognostic features of intravenous leiomyomatosis (IVL) with inferior vena cava extension (IVCE) or intracardiac extension (ICE).

    Methods: A retrospective analysis was conducted of the clinical data of 38 patients with pathologically diagnosed IVL with IVCE or ICE.

    Results: The mean age of the patients was 44. Read More

    Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum.
    Cardiovasc Pathol 2017 Jun 4;30:1-5. Epub 2017 Jun 4.
    Department of Medical and Clinical Genetics and Genome-Scale Biology Research Program, P.O. Box 63, FIN-00014, University of Helsinki, Helsinki, Finland.
    A male patient with obstructive jaundice was found to have an incidental nodule within the inferior vena cava (IVC), below the level of the renal vein, on abdominal imaging. At the time of the Whipple's procedure for pancreatic adenocarcinoma, the IVC mass measuring 3.4×2. Read More

    Endoscopic ultrasound with tissue sampling is accurate in the diagnosis and subclassification of gastrointestinal spindle cell neoplasms.
    Endosc Ultrasound 2017 May-Jun;6(3):174-180
    Department of Gastroenterology and Hepatology, University of Iowa Hospital and Clinics, Iowa, USA.
    Background And Objectives: Mesenchymal (spindle cell) neoplasms (SCN) of the gastrointestinal (GI) tract are an important subtype of subepithelial lesions that need subclassification to assess their malignant potential. Reported success rates of accurate subclassification with endoscopic ultrasound (EUS)-guided biopsies are variable. Our goal was to analyze our experience using EUS-guided TruCut biopsy (EUS-TCB) in the majority of patients. Read More

    Role of endoscopic ultrasound and endoscopic-ultrasound-guided fine-needle aspiration in endoscopic biopsy negative gastrointestinal lesions.
    Endosc Ultrasound 2017 May-Jun;6(3):156-161
    Department of Internal Medicine and Gastroenterology, Cairo University, Cairo, Egypt.
    Background And Objectives: Many cases of gastrointestinal (GI) tumors as lymphoma, adenocarcinoma, and most of submucosal tumors (SMT) such as gastrointestinal stromal tumor (GIST) and leiomyoma are difficult to diagnose as they frequently yield negative endoscopic biopsies. We evaluated the accuracy of endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) in the diagnosis of endoscopic biopsy negative GI tumors.

    Patients And Methods: One hundred and nine patients with biopsy negative GI tumors were included in this prospective study. Read More

    Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
    Biomed Pharmacother 2017 Jun 10;92:810-818. Epub 2017 Jun 10.
    Cambridge-Suda (CAM-SU) Genome Resource Center, Soochow University, and Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215123, China. Electronic address:
    Leiomyosarcoma is a rare malignant smooth muscle tumor which can be very unpredictable. Myosin II is involved in many functions, including cell contraction, migration, and adhesion. The phosphorylation of myosin regulatory light chain (MLC) by myosin light chain kinase (MLCK) determines the activity of Myosin II. Read More

    [Clinical Value of Prophylactic Salpingectomy in Hysterectomy due to Uterine Benign Lesions].
    Sichuan Da Xue Xue Bao Yi Xue Ban 2017 Mar;48(2):314-317
    Departments of Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
    Objectives: To explore the clinical value of resection of bilateral fallopian tubes in patients with benign uterine diseases who received (laparoscopic) hysterectomy or subhysterectomy through the postoperative pathologic analysis of resected fallopian tubes.

    Methods: A retrospective analysis was conducted to review the histopathological examination results in 1 272 women who underwent (laparoscopic) total hysterectomy or subtotal hysterectomy and the removal of bilateral fallopian tube simultaneously due to uterine leiomyoma, adenomyosis and other benign lesions from December 2010 to December 2015.

    Results: Of the 1 272 patients, laparoscopic resection was underwent in 1 005 patients (79. Read More

    Immunoexpression of p16 in uterine leiomyomas with infarct-type necrosis: an analysis of 35 cases.
    Histopathology 2017 Jun 13. Epub 2017 Jun 13.
    Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston.
    Aims: Uterine leiomyosarcomas frequently show p16 immunoexpression. However, p16 may also be expressed in some benign leiomyoma variants such as leiomyomas with bizarre nuclei and cellular leiomyomas, limiting its utility as a biomarker to distinguish between benign and malignant neoplasms. We investigated p16 expression in leiomyomas with infarct-type necrosis, tumours which may sometimes be misinterpreted as smooth muscle tumors of uncertain malignant potential or even leiomyosarcoma on conventional light microscopy. Read More

    Molecular targets of dietary phytochemicals for possible prevention and therapy of uterine fibroids: Focus on fibrosis.
    Crit Rev Food Sci Nutr 2017 Nov;57(17):3583-3600
    a Department of Experimental and Clinical Medicine , Faculty of Medicine, Università Politecnica delle Marche , Ancona , Italy.
    Uterine fibroids (myomas or leiomyomas) are common benign tumors of reproductive aged women. Fibroids are clinically apparent in 20-50% of women, and cause abnormal uterine bleeding, abdominal pain and discomfort, pregnancy complications and infertility. Unfortunately, limited numbers of medical treatment are available but no effective preventive strategies exist. Read More

    Abnormal Uterine Bleeding.
    Rev Bras Ginecol Obstet 2017 Jun 12. Epub 2017 Jun 12.
    Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
    Abnormal uterine bleeding is a frequent condition in Gynecology. It may impact physical, emotional sexual and professional aspects of the lives of women, impairing their quality of life. In cases of acute and severe bleeding, women may need urgent treatment with volumetric replacement and prescription of hemostatic substances. Read More

    Intravenous leiomyomatosis of the uterus: A clinicopathological analysis of nine cases and literature review.
    Taiwan J Obstet Gynecol 2017 Jun;56(3):362-365
    Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan; Chung Shan Medical University, Taichung, Taiwan. Electronic address:
    Objective: Intravenous/intravascular leiomyomatosis is characterized by intravenous proliferation of a histologically benign smooth muscle cell tumor mass that is non-tissue-invasive. Although benign, intravenous leiomyomatosis may cause remarkable systematic complications, presents significant diagnostic difficulties, and also is characterized by a relatively increased possibility of recurrence. We determine patients' characteristics, and recurrence and treatment of intravenous leiomyomatosis. Read More

    Effects of liver depression and psychological stress on human uterine leiomyoma cells by an AR-cAMP-PKA signal transduction pathway.
    Taiwan J Obstet Gynecol 2017 Jun;56(3):291-301
    Department of Infertility, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China.
    Objective: Based on the emotional theory of Traditional Chinese Medicine, and combined with the modern medicine theory of psychological stress, a research model of human uterine leiomyoma cells (ULM) was cultured in vitro to determine the effectiveness of adrenergic receptor (AR) agonists in human ULM cell growth. In addition, we studied the functional influence of "liver depression and psychological stress theory" on fibroid formation by intervening in the AR-cAMP-PKA signaling pathway. The intention was to establish a new method to prevent and cure fibroids through "liver depression and psychological stress theory" and provide an experimental basis for the Traditional Chinese Medicine emotional theory. Read More

    Uterine-sparing Laparoscopic Resection of Accessory Cavitated Uterine Masses.
    J Minim Invasive Gynecol 2017 Jun 6. Epub 2017 Jun 6.
    Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, PA, United States. Electronic address:
    To demonstrate surgical techniques utilized during uterine-sparing laparoscopic resections of accessory cavitated uterine masses (ACUM) BACKGROUND: ACUM represent a rare uterine entity observed in premenopausal women suffering from dysmenorrhea and recurrent pelvic pain. The diagnosis is made when an isolated extra-cavitated uterine mass is resected from an otherwise normal appearing uterus with unremarkable endometrial lumen and adnexal structures. Pathologic confirmation requires an accessory cavity lined with endometrial epithelium (and corresponding glands and stroma) filled with chocolate-brown fluid. Read More

    Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors.
    Mol Cancer 2017 Jun 7;16(1):101. Epub 2017 Jun 7.
    Research Programs Unit, Genome-Scale Biology Research Program and Medicum, Department of Medical and Clinical Genetics, FIN-00014 University of Helsinki, P.O. Box 63, Helsinki, Finland.
    Uterine smooth muscle tumors range from benign leiomyomas to malignant leiomyosarcomas. Based on numerous molecular studies, leiomyomas and leiomyosarcomas mostly lack shared mutations and the majority of tumors are believed to develop through distinct mechanisms. To further characterize the molecular variability among uterine smooth muscle tumors, and simultaneously insinuate their potential malignant progression, we examined the frequency of known genetic leiomyoma driver alterations (MED12 mutations, HMGA2 overexpression, biallelic FH inactivation) in 65 conventional leiomyomas, 94 histopathological leiomyoma variants (18 leiomyomas with bizarre nuclei, 22 cellular, 29 highly cellular, and 25 mitotically active leiomyomas), and 51 leiomyosarcomas. Read More

    Prospective Cohort Study of Uterine Fibroids and Miscarriage Risk.
    Am J Epidemiol 2017 Jun 7:1-9. Epub 2017 Jun 7.
    We sought to determine the relationship of fibroids to pregnancy loss in a prospective cohort in which fibroid status was uniformly documented in early pregnancy. Participants had an intake interview, transvaginal ultrasonography, computer-assisted telephone interview, and follow-up assessment of outcomes. We recruited diverse participants for the Right From the Start study from 8 metropolitan areas in 3 states in the United States during 2000-2012. Read More

    Genetic heterogeneity in leiomyomas of deep soft tissue.
    Oncotarget 2017 May 17. Epub 2017 May 17.
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
    Leiomyoma of deep soft tissue is a rare type of benign smooth muscle tumor that mostly occurs in the retroperitoneum or abdominal cavity of women, and about which very little genetic information exists. In the present study, eight leiomyomas of deep soft tissue were genetically analyzed. G-banding showed that three tumors carried rearrangements of the long arm of chromosome 12, three others had 8q rearrangements, the 7th tumor had deletion of the long arm of chromosome 7, del(7)(q22), and the 8th had aberrations of chromosome bands 3q21~23 and 11q21~22. Read More

    Angioleiomyoma (Vascular Leiomyoma) of the Oral Cavity.
    Head Neck Pathol 2017 Jun 6. Epub 2017 Jun 6.
    Department of Oral & Maxillofacial Surgery, School of Dentistry, University of Washington, B-204 Magnuson Health Sciences Center, 1959 NE Pacific Street, Box 357133, Seattle, WA, 98195, USA.
    A 70-year-old male presented with a slow growing, dome shaped and painless mass of the hard palate. The mass was excised. Histopathological examination confirmed the diagnosis of a angioleiomyoma (vascular leiomyoma). Read More

    Expression Profiling of lncRNAs, miRNAs, and mRNAs and Their Differential Expression in Leiomyoma Using Next-Generation RNA Sequencing.
    Reprod Sci 2017 Jan 1:1933719117711265. Epub 2017 Jan 1.
    1 LA-Biomed Research Institute, Torrance, CA, USA.
    The objective of this study was to identify the expression profile of long noncoding RNAs (lncRNAs) with concurrent assessment of microRNA (miRNA) and messenger RNA (mRNA) profiles in leiomyomas and paired myometrium using next-generation RNA sequencing and assembly of RNA transcripts. Total RNA was isolated from leiomyoma and paired myometrium (N = 8) and samples from 3 pairs were subjected to RNA sequencing. Normalized assembly of over 48 000 lncRNAs resulted in identification of 45 936 lncRNAs. Read More

    Hypovolemic Shock and Hemoperitoneum from Spontaneous Avulsion of a Large Pedunculated Uterine Leiomyoma.
    J Radiol Case Rep 2017 Mar 31;11(3):15-21. Epub 2017 Mar 31.
    Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, USA.
    Hemoperitoneum with hypovolemic shock from avulsion of a pedunculated leiomyoma is a rare but highly fatal condition that can occur spontaneously or as a result of trauma. We report a case of hemoperitoneum and hypovolemic shock secondary to a bleeding leiomyoma detected via computed tomography (CT) scan in a 39 year old premenopausal, gravida 0 female that presented with abdominal pain and became hemodynamically unstable in the emergency department. A preoperative bimanual exam revealed a mass consistent with a 20 week gestational uterus. Read More

    Disseminated Peritoneal Leiomyomatosis Status Post Laparoscopic Hysterectomy with Morcellation.
    J Radiol Case Rep 2016 Dec 31;10(12):12-18. Epub 2016 Dec 31.
    Department of Radiology, Morristown Medical Center, Morristown, NJ, USA.
    Uterine leiomyomas (fibroids) are common benign neoplasms, which develop from the muscular tissue of the uterus with an estimated incidence of 20-40% in women of reproductive age. In the early nineties, power morcellators were introduced and became commonly used during hysterectomy for symptomatic fibroids. However, if all fragments are not removed, they may parasitize to other blood supply and present as abdominal or pelvic masses. Read More

    Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a phase 2a proof-of-concept study.
    Fertil Steril 2017 Jun 1. Epub 2017 Jun 1.
    AbbVie Inc, North Chicago, Illinois.
    Objective: To evaluate the safety and efficacy of elagolix vs. placebo and elagolix with low-dose E2/progestogen add-back therapy.

    Design: Proof-of-concept, dose-ranging, multiple-cohort study. Read More

    Catheter probe endoscopic ultrasonography by using cold lubricating jelly-filled method for esophageal subepithelial tumors.
    Dis Esophagus 2017 Aug;30(8):1-6
    Department of Internal Medicine, Gangneung Asan Hospital, Ulsan University College of Medicine, Gangneung, Korea.
    Catheter probe endoscopic ultrasonography (C-EUS) by ultrasonographic jelly-filled method has been used to evaluate esophageal subepithelial tumors (SETs). Ultrasonographic jelly is safe on the skin, but its internal safety has not been demonstrated. The jelly stored at room temperature is easily injected into the esophagus through the instrument channel of the endoscope. Read More

    Giant Leiomyoma of the Oesophagus.
    J Clin Diagn Res 2017 Apr 1;11(4):PD07-PD08. Epub 2017 Apr 1.
    Assistant Professor, Department of Cardiothoracic Surgery, Government Stanley Medical College, Chennai, India.
    Leiomyomas are rare benign tumours of the oesophagus that remain silent in more than 50% of the cases. Giant leiomyomas measuring more than 5 cm are very rare. A 47-year-old female presented with chest pain, cough and dysphagia for two months. Read More

    Bilateral Synchronous Paratesticular Leiomyoma - A Rare Entity.
    J Clin Diagn Res 2017 Apr 1;11(4):PD05-PD06. Epub 2017 Apr 1.
    Professor, Department of Urology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
    Paratesticular region is an obscure anatomical region that includes spermatic cord and its contents, tunica of the testes, epididymis and appendices of epididymis and testis. Paratesticular tumours may closely resemble and be clinically indistinguishable from testicular tumours, resulting in a diagnostic dilemma. Preoperative distinction between the benign and malignant paratesticular tumour is extremely difficult, resulting in difficulty in diagnosis and management. Read More

    A Large Posteriorly Located Prostatic Mass Lesion Challenging the Robotic Surgeon: Prostate Leiomyoma.
    J Endourol Case Rep 2017 1;3(1):61-63. Epub 2017 May 1.
    Department of Pathology, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, School of Medicine, Ankara, Turkey.
    Background: Prostatic leiomyoma is a benign and rare condition of the prostate. Robotic surgery is increasingly being applied in the surgical management of prostate cancer. Case Presentation: Herein, a mass lesion that was located in the posterior part of the prostate between seminal vesicles that was identified during robotic surgery is presented. Read More

    Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models.
    Oncotarget 2017 May 10. Epub 2017 May 10.
    Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
    The crosstalk between immune cells, cancer cells, and extracellular vesicles (EVs) secreted by cancer cells remains poorly understood. We created three-dimensional (3D) cell culture models using human leiomyoma discs and Myogel to study the effects of immune cells on highly (HSC-3) and less (SCC-25) invasive oral tongue squamous cell carcinoma (OTSCC) cell lines. Additionally, we studied the effects of EVs isolated from these cell lines on the cytotoxicity of CD8+ T and NK cells isolated from three healthy donors. Read More

    Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report.
    Gynecol Oncol Rep 2017 Aug 5;21:1-4. Epub 2017 May 5.
    Department of Pathology, University of Washington, Seattle, WA, United States.
    We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus. Histologic sections of the mass contained a leiomyoma with interspersed foci of malignant epithelioid cells forming anastomosing vascular channels. The neoplastic cells were diffusely positive for CD31 and FLI1, supporting the morphologic impression of epithelioid angiosarcoma. Read More

    Benign Metastasizing Leiomyomas Following Myomectomy and Uterine Artery Embolization.
    Cardiovasc Intervent Radiol 2017 May 23. Epub 2017 May 23.
    Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Road NW, CCC - CG201, Washington, DC, 20007, USA.
    Benign metastasizing leiomyomas (BMLs) are rare sequelae of common uterine leiomyomas and most frequently found in the lungs. Most cases of BMLs occur with a history of prior gynecologic procedures; however, none have yet been reported in association with uterine artery embolization (UAE). This case report highlights the disease course for a 48-yo female with a history of both myomectomy and UAE for uterine fibroids who presented later with bilateral pulmonary BMLs. Read More

    Incarceration of a pedunculated uterine fibroid in an umbilical hernia.
    Obstet Gynecol Sci 2017 May 15;60(3):318-321. Epub 2017 May 15.
    Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
    Uterine fibroids are common benign tumors that may cause an umbilical hernia in patients with increased intra-abdominal pressure due to pregnancy, obesity, ascites, and intra-abdominal tumors. However, the simultaneous occurrence of uterine fibroids and umbilical hernias, or fibroids and an associated umbilical hernia, during pregnancy has rarely been reported. Here, we present the case of a fibroid presenting as an incarcerated umbilical hernia in a menopausal patient. Read More

    Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma.
    Oncotarget 2017 May 9. Epub 2017 May 9.
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Linkou Medical Center, Taoyuan, Taiwan.
    Benign metastasizing leiomyoma (BML) is a rare disease entity typically presenting as multiple extrauterine leiomyomas associated with a uterine leiomyoma. It has been hypothesized that the extrauterine leiomyomata represent distant metastasis of the uterine leiomyoma. To date, the only molecular evidence supporting this hypothesis was derived from clonality analyses based on X-chromosome inactivation assays. Read More

    Identification of proteins with different abundance associated with cell migration and proliferation in leiomyoma interstitial fluid by proteomics.
    Oncol Lett 2017 May 29;13(5):3912-3920. Epub 2017 Mar 29.
    Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', I-34137 Trieste, Italy.
    Uterine leiomyoma is the most common female reproductive tract benign tumor. Little is known about protein composition and changes in the leiomyoma interstitial fluid (IF). The present study focused on changes in protein abundance in the IF of leiomyoma. Read More

    Total laparoscopic hysterectomy for large uterine cervical myoma.
    Mol Clin Oncol 2017 May 10;6(5):655-660. Epub 2017 Apr 10.
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan.
    Ureterolysis is a surgical method with a high level of difficulty, which may be necessary when performing total laparoscopic hysterectomy (TLH) for large cervical myoma, despite the benign nature of this tumor. The aim of the present study was to introduce techniques that are commonly applied in malignant tumor surgery in order to safely perform TLH for large cervical myoma. Between 2014 and 2016, TLH was performed at the Shimane University Hospital (Izumo, Japan) in 153 patients with benign tumors, including 25 cases with a large uterus (uterine weight ≥500 g). Read More

    Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma.
    Cold Spring Harb Mol Case Stud 2017 May 16. Epub 2017 May 16.
    Canada's Michael Smith Genome Sciences Centre;
    Introduction: We describe a woman with the known pathogenic germline variant CHEK2:c.1100delC and synchronous diagnoses of both pelvic genital type leiomyosarcoma and metastatic invasive ductal breast carcinoma. CHEK2 (checkpoint kinase 2) is a tumour suppressor gene encoding a serine/threonine-protein kinase (CHEK2) involved in double-strand DNA break repair and cell cycle arrest. Read More

    Cuff Closure by Vaginal Route in TLH: Case Series and Review of Literature.
    J Clin Diagn Res 2017 Mar 1;11(3):QD01-QD03. Epub 2017 Mar 1.
    Professor, Department of Obstetrics and Gynaecology, İzmir Katip Çelebi University, School of Medicine, İzmir, Karabağlar, Turkey.
    Total Laparoscopic Hysterectomy (TLH) represents one of the most performed gynaecological procedures nowadays. The closure of the vaginal cuff is the most diffucult part of TLH because of the difficulty of laparoscopic suturing techniques. Our aim was to evaluate the efficacy and safety of vaginal cuff closure by vaginal route on patients submitted to TLH. Read More

    Comparison of Pain Within 24 h after Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres Versus Gelatin Sponge Particles for Leiomyoma.
    Cardiovasc Intervent Radiol 2017 May 15. Epub 2017 May 15.
    Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan.
    Purpose: To compare acute pain after uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM) versus gelatin sponge particles (GS) for leiomyoma.

    Materials And Methods: This was a single-institution, retrospective study. Between July 2008 and November 2016, 101 consecutive patients with symptomatic uterine leiomyoma underwent UAE with the same protocol for post-procedural pain. Read More

    Undiagnosed Uterine Sarcomas Identified During Surgery for Presumed Leiomyoma at a National Tertiary Hospital in Thailand: A 10-Year Review.
    Int J Gynecol Cancer 2017 Jun;27(5):973-978
    Divisions of *Gynecologic Oncology and †Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, and ‡Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Objectives: The aim of this study was to evaluate the rate, clinical characteristics, and survival outcomes of an undiagnosed uterine malignancy in patients who underwent surgical treatment for presumed leiomyomas.

    Methods: Medical records of patients who underwent surgical treatment for presumed leiomyomas, from January 2004 to September 2013, were retrospectively reviewed, and the data were followed until September 2016. Demographic data, tumor characteristics, oncologic treatment, and response rate were analyzed by descriptive statistics. Read More

    Endoscopic Ultrasonography in the Diagnosis and Treatment Strategy Choice of Esophageal Leiomyoma.
    Clinics (Sao Paulo) 2017 Apr;72(4):197-201
    Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University, Zhejiang, China.
    Objectives:: Esophageal leiomyoma is the most common benign tumor of the esophagus, and it originates from mesenchymal tissue. This study analyzed the clinicopathological characteristics of esophageal leiomyoma and aimed to evaluate the role of endoscopic ultrasonography in the diagnosis and treatment selection for these lesions.

    Methods:: Two hundred and twenty-five patients who had suspected esophageal leiomyomas in endoscopic ultrasonography were enrolled at the Endoscopy Center of The First Affiliated Hospital, Zhejiang University from January 1st, 2009 to May 31th, 2015. Read More

    Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1.
    Am J Surg Pathol 2017 Jun;41(6):773-780
    *ArcherDX Inc., Boulder, CO†Department of Histopathology, King Edward Memorial Hospital, Perth, WA§Sullivan Nicolaides Pathology, Brisbane, Qld, Australia‡Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB#Department of Pathology, British Columbia Cancer Agency and Vancouver General Hospital, Vancouver, BC, Canada∥Department of Pathology, Royal Devon and Exeter Hospital, Exeter**Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK¶Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
    Inflammatory myofibroblastic tumor (IMT) can occur in a number of anatomic sites, including the uterus. Like its soft tissue counterpart, uterine IMT frequently expresses ALK and harbors ALK genetic rearrangements. The aim of this study is to fully characterize the genetic fusions that occur in uterine IMT. Read More

    Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia.
    Anemia 2017 13;2017:9642027. Epub 2017 Apr 13.
    Department of Obstetrics and Gynecology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
    Objective. To evaluate safety and efficacy of intravenous ferric carboxymaltose (FCM) versus standard medical care (SMC) for iron-deficiency anemia (IDA) in postpartum women and women with heavy menstrual bleeding. Study Design. Read More

    Primary Hydatid Cyst Mimicking Uterine Leiomyoma.
    Turkiye Parazitol Derg 2017 Mar;41(1):57-59
    Clinic of Pathology, İstanbul Zeynep Kamil Woman and Child Diseases Hospital, İstanbul, Turkey.
    Here, we present a rare case of a hydatid cyst in a 25-year-old woman, mimicking a uterine leiomyoma. The patient was admitted with lower abdominal pain and tenesmus, and ultrasonographic examination revealed a 10×10 cm uniloculated mass with regular borders in the myometrium. The patient was operated with an initial diagnosis of a uterine leiomyoma with cystic degeneration, which was found to be hydatid cyst during frozen section and confirmed with the identification of protoscoleces during microscopy. Read More

    Oxidative stress: a key regulator of leiomyoma cell survival.
    Fertil Steril 2017 Jun 5;107(6):1387-1394.e1. Epub 2017 May 5.
    Department of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan. Electronic address:
    Objective: To determine the effects of attenuating oxidative stress with the use of dichloroacetate (DCA) on the expression of key redox enzymes myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) as well as on apoptosis.

    Design: Prospective experimental study.

    Setting: University medical center. Read More

    A Novel Diagnostic Strategy Using 16α-[18F]-Fluoro-17-β-Estradiol (18F-FES) PET/MRI to Achieve Complete Resection of Intravenous Leiomyomatosis in Reproductive-Age Women.
    Clin Nucl Med 2017 Jul;42(7):e335-e336
    From the *Department of Obstetrics and Gynecology, Faculty of Medical Sciences, and †Biomedical Imaging Research Center, University of Fukui, Fukui, Japan.
    Intravenous leiomyomatosis is a life-threatening leiomyoma that grows into the extrauterine venous system. A high recurrence rate has been reported in reproductive-age women who undergo only tumor excision to preserve fertility. Precise diagnosis of tumor extension is essential to achieve complete resection. Read More

    Leiomyoma Infarction after Uterine Artery Embolization: Influence of Embolic Agent and Leiomyoma Size and Location on Outcome.
    J Vasc Interv Radiol 2017 May 4. Epub 2017 May 4.
    Department of Radiology, Georgetown University Hospital, 3800 Reservoir Rd. NW, CG 201, Washington, DC 20007-2113.
    Purpose: To study the factors that might impact infarction of individual uterine leiomyomas and total tumor burden after uterine artery embolization (UAE).

    Materials And Methods: This retrospective study included 91 patients (mean age, 44 y [range, 34-54 y]) who underwent UAE with tris-acryl gelatin microspheres (TAGMs) or nonspherical polyvinyl alcohol (PVA) particles. Twenty-one patients were treated with PVA (23%) and 70 were treated with TAGMs (77%). Read More

    1 OF 425