1,800 results match your criteria Legal Medicine [Journal]


Worldwide tendency and focused research in forensic anthropology: A bibliometric analysis of decade (2008-2017).

Leg Med (Tokyo) 2019 Jan 22;37:67-75. Epub 2019 Jan 22.

College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China; Key Laboratory of the Health Ministry for Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China; Key Laboratory of Shaanxi Province for Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an, Shaanxi, PR China. Electronic address:

Purpose: The objective of this study was to illustrate the global research productivity and tendency of forensic anthropology in recent ten years (2008-2017) by bibliometric analysis.

Methods: "Forensic anthropology" was used as the Medical Subject Headings term and topic in PubMed and Web of Science Core Collection.

Results: As 5130 articles retrieved, two independent investigators evaluated all of them respectively. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.008DOI Listing
January 2019
1 Read

Genetic polymorphism of 27 X-chromosomal short tandem repeats in an Egyptian population.

Leg Med (Tokyo) 2019 Jan 24;37:64-66. Epub 2019 Jan 24.

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

We presented allele frequencies of 27 X-chromosomal short tandem repeats (DXS6807, DXS9902, DXS6795, DXS6810, DXS10076, DXS10077, DXS10078, DXS10162, DXS10163, DXS10164, DXS7132, DXS981, DXS6800, DXS6803, DXS6809, DXS6789, DXS6799, DXS7424, DXS101, DXS7133, GATA172D05, DXS10103, HPRTB, GATA31E08, DXS8377, DXS10147, and DXS7423) obtained from 352 unrelated individuals in Egypt. No deviation from Hardy-Weinberg equilibrium was detected. Two pairs of adjacent loci showed significant linkage disequilibrium. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.009DOI Listing
January 2019

Evaluation of the effect of heat damage on DNA extracted from the dental pulp of restored teeth.

Leg Med (Tokyo) 2019 Jan 14;37:54-59. Epub 2019 Jan 14.

Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México 073201, Mexico. Electronic address:

We evaluate structural damage effects of heat on DNA obtained from the dental pulp of restored premolars. We studied three groups (A, B and C) each group comprised twenty premolars extracted from five patients. Three of the four premolars of each donator were restored with different materials: amalgam, glass ionomer and resin, and one unrestored premolar was used as control. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.006DOI Listing
January 2019

Facial approximation: Soft tissue thickness values for Caucasian males using cone beam computer tomography.

Leg Med (Tokyo) 2019 Jan 4;37:49-53. Epub 2019 Jan 4.

Department of Interdisciplinary Medicine, Section of Legal Medicine, Policlinico di Bari Hospital, University of Bari, Bari, Italy.

The aim of this study was to obtain soft tissue thickness (STTs) of Caucasian males starting from 12 bone landmarks, to allow facial reconstruction and assign an identity to skeletal remains. When a skeleton is found without any circumstantial evidence of identity, through anthropological investigations it is possible to estimate age, sex, and race studying specific characteristics of bones. This first step of identification process helps investigators to narrow down the identity suppositions, but not always forensic analysis guarantees a final positive identification. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.002DOI Listing
January 2019

Genotyping of 49-plex autosomal SNP panel in Iranian Turkmens ethnic group.

Leg Med (Tokyo) 2019 Jan 2;37:45-48. Epub 2019 Jan 2.

Human Genetic Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

A total of 94 unrelated individuals from Turkmens ethnic group in Iran were typed for forty-nine of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex using the SNaPshot assay. Allele frequencies are presents for the 49 SNPs. No deviation from Hardy-Weinberg equilibrium (HWE) was observed in all but one of the 49 SNP systems and no significant linkage disequilibrium was detected for any SNP pairs. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.004DOI Listing
January 2019
4 Reads

Identification of extra alleles in DYS385a/b multi-allelic patterns.

Leg Med (Tokyo) 2019 Jan 2;37:41-44. Epub 2019 Jan 2.

AGCU ScienTech Incorporation, Wuxi 214174, China; School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

Y chromosome short tandem repeats (Y-STRs) are widely used in forensic DNA analysis. Y-STRs usually genotyped as a monoallelic pattern, or a diallelic pattern at some double-copy loci. Abnormal genotypes with three or four alleles have been reported at DYS385a/b, which is a double-copy locus. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.003DOI Listing
January 2019
1 Read

Investigation on STR profiling of maternal DNA from a degraded placenta with an abandoned newborn male baby.

Leg Med (Tokyo) 2019 Jan 2;37:37-40. Epub 2019 Jan 2.

Seoul Institute, National Forensic Service, 139, Jiyang-ro, Yangcheon-gu, Seoul 08036, Republic of Korea.

The placenta is a unique and complex organ composed of a mixture of fetal and maternal tissues. In this study, we aimed to detect maternal short tandem repeats (STRs) in degraded placenta from a newborn male baby found abandoned in a river. In order to deduce maternal alleles-which was not possible by sampling of different parts of the placenta-we collected samples from the maternal blood pool in the intervillous space and applied a multi-step method (named tempo-gap DNA extraction) for extracting DNA at defined time points after cell lysis (10 min, 2 h 10 min, and 4 h 10 min). Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.001DOI Listing
January 2019
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Forensic parameters and mutation analysis of 23 short tandem repeat (PowerPlex® Fusion System) loci in Fujian Han Chinese population.

Leg Med (Tokyo) 2019 Jan 2;37:33-36. Epub 2019 Jan 2.

Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, PR China; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, PR China. Electronic address:

Kinship testing based on genetic markers has valuable practical applications. Short tandem repeat polymorphisms (STRPs) can have large number of alleles, and become the dominant marker for kinship identification. However, the high mutation rates affect the identification accuracy. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.01.005DOI Listing
January 2019
8 Reads

Age estimation based on maturation of the medial clavicular epiphysis in a Japanese population using multidetector computed tomography.

Leg Med (Tokyo) 2018 Dec 23;37:28-32. Epub 2018 Dec 23.

Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Education and Research Center of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address:

To estimate forensic age, the Study Group of Forensic Age Diagnostics of the German Association of Forensic Medicine (AGFAD) has recommended the radiological investigation of the medial clavicular epiphysis (MCE). This study aimed to investigate the relation between the maturation of the MCE and age in a contemporary Japanese population using a standard five-stage system by Schmeling et al. and Kellinghaus substage system. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.12.003DOI Listing
December 2018

Forensic parameters of 15 autosomal STRs (Identifiler™ kit) in three Mayan groups and one Mestizo population from Guatemala.

Leg Med (Tokyo) 2018 Dec 24;37:25-27. Epub 2018 Dec 24.

Instituto de Investigación en Genética Molecular, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, Jalisco, Mexico. Electronic address:

The population of Guatemala includes Mestizos (admixed) and different Mayan groups (Native Americans), which have been poorly studied in regards to short tandem repeat (STR) loci used for human identification (HID) purposes. Therefore, 483 unrelated Guatemalan volunteers from one Mestizo and three Mayan populations (Poqomchi, Ixil, and Achi) were analyzed with an AmpFlSTR Identifiler™ kit. Allele frequencies and forensic parameters were obtained for 15 autosomal STRs in these populations. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.12.004DOI Listing
December 2018

Age estimation based on the volume change in the maxillary premolar crown using micro CT.

Leg Med (Tokyo) 2018 Dec 15;37:18-24. Epub 2018 Dec 15.

Division of Forensic Odontology, Department of Diagnostic & Therapeutic Science, Meikai University School of Dentistry, Saitama, Japan; Forensic Odontology Center, Meikai University School of Dentistry, Saitama, Japan.

Age is often estimated using teeth because numerous external and internal changes appear due to aging. The purpose of this study was to investigate an age estimation method based on the volume ratio of the internal structure of the crown. 61 maxillary first premolars and 50 maxillary second premolars from subjects aged 20-79 years old were used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13446223183032
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http://dx.doi.org/10.1016/j.legalmed.2018.12.001DOI Listing
December 2018
1 Read

DNA extraction of urinary bladder swabs collected from carbonized and decomposing corpses: Possible application in disaster victim identification.

Leg Med (Tokyo) 2018 Dec 17;37:15-17. Epub 2018 Dec 17.

Post Graduate Studies in Genetics and Molecular Biology (Pós Graduação em Genética e Biologia Molecular), UNIRIO, Rio de Janeiro, Brazil; Forensic Genetics Research Institute (Instituto de Pesquisa e Perícias em Genética Forense), IPPGF/PCERJ, Rio de Janeiro, Brazil.

A disaster is an unexpected event causing death or injury to many people. In such events, a large number of casualties may take place, exposing corpses to a harsh environment for days or months. DNA profiling is recognized as one of the primary methods for identifying mass disaster victims, especially when it involves decomposed or fragmented bodies. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.12.002DOI Listing
December 2018
1 Read

Cellular uptake of paraquat determines subsequent toxicity including mitochondrial damage in lung epithelial cells.

Leg Med (Tokyo) 2018 Nov 22;37:7-14. Epub 2018 Nov 22.

Department of Forensic Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.

Paraquat (PQ) is one of the commonly used herbicides in the world, despite its high toxicity. The ingestion of PQ accidentally or intentionally causes severe damage in diverse organs including the lung. Pulmonary fibrosis triggered by PQ accumulation in the lung epithelial cells is one of the major causes of death. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.008DOI Listing
November 2018
1 Read

Detection of cocaine and metabolites from mouse femur buried in soil.

Leg Med (Tokyo) 2018 Nov 9;37:1-6. Epub 2018 Nov 9.

Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

Drug addicts are frequently involved in committing homicides, and burial in the ground is often performed by offenders for body disposal. Therefore, toxicological analyses of buried bones are vitally important for investigating the cause and circumstance of death. Cocaine concentrations in heart blood, femoral muscle, and femur were measured in mice after injections of 5, 15, and 30 mg/kg cocaine and in femurs buried in soil. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.005DOI Listing
November 2018
4 Reads

Genetic diversity and haplotype structure of 27 Y-STR loci in a Yanbian Korean population from Jilin Province, Northeast China.

Leg Med (Tokyo) 2019 Feb 22;36:110-112. Epub 2018 Nov 22.

Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Forensic Science Center of Jining Medical University, Jining, Shandong 272067, PR China. Electronic address:

In this study, 27 Y-STRs were analyzed in 347 male individuals from the Yanbian Korean population. Haplotype diversity (HD) and discrimination capacity (DC) values were calculated. Pairwise R values were evaluated in AMOVA analysis and visualized through multidimensional scaling (MDS). Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.010DOI Listing
February 2019

Collagen degradation as a possibility to determine the post-mortem interval (PMI) of human bones in a forensic context - A survey.

Leg Med (Tokyo) 2019 Feb 22;36:96-102. Epub 2018 Nov 22.

Institute of Biologic Anthropology, Albert-Ludwigs-University, Hebelstraße 29, 79104 Freiburg im Breisgau, Germany.

To find out the time since death (PMI) of a human individual, from which only skeletal remains are left is a difficult question to answer, since methods currently available don't bring concrete answers. Subsequent to our validation study on porcine bones, we focused on human bones analysing if collagen degradation would occur at a predictive rate so that the method may be used for PMI-estimation. We tried to reproduce a method for determining the Co/NCo (Collagen to Non-Collagen) ratio of porcine bones Boaks et al. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.009DOI Listing
February 2019
1 Read

Use of a proforma to aid in reducing coercion into informal admission for acute adult psychiatric inpatients in the U.K.

Leg Med (Tokyo) 2019 Feb 23;36:103-109. Epub 2018 Nov 23.

Coventry and Warwickshire Partnership NHS Trust, Caludon Centre, Clifford Bridge Road, Coventry, England CV2 2TE, United Kingdom.

Background: People with acute psychiatric illness may be at risk of coercion into informal admission. A lack of capacity assessment (CA) and provision of adequate information (PAI) for informal patients may constitute a risk of coercive admitting practice, resulting in increased use of the mental health act (MHA) in the days following admission. We developed and tested a proforma to aid in ensuring CA and PAI for informal admissions. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.011DOI Listing
February 2019

The epidemiology of sexual assault of older female nursing home residents, in Victoria Australia, between 2000 and 2015.

Leg Med (Tokyo) 2019 Feb 10;36:89-95. Epub 2018 Nov 10.

Department of Forensic Medicine, Monash University, Southbank, Victoria 3006, Australia.

Sexual assault is the least acknowledged, detected, and reported type of assault against nursing home residents. Nursing home staff are responsible for reporting suspected allegations to the police, who will contact a clinical forensic examiner to conduct a forensic medical examination. This study examined the epidemiology of sexual assaults of older women (aged 65 years and older) residing in nursing homes in Victoria, Australia, between 2000 and 2015, whose alleged incidents were referred to a clinical forensic examiner for a forensic medical examination. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.006DOI Listing
February 2019
7 Reads

Extensive gastric necrosis secondary to acute gastric dilatation: A case report.

Leg Med (Tokyo) 2019 Feb 13;36:85-88. Epub 2018 Nov 13.

Department of Legal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.

We report a case of sudden death in a patient who developed extensive gastric necrosis secondary to acute gastric dilatation. A 36-year-old man with mental retardation (but without difficulties in activities of daily living), developed an illness after a meal out with friends, necessitating 3 hospital visits. He returned home after receiving drug therapy; however, his condition deteriorated, and he was transferred to our hospital via ambulance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13446223183032
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http://dx.doi.org/10.1016/j.legalmed.2018.11.007DOI Listing
February 2019
11 Reads

Fatal accidental asphyxia in the reverse jack-knife position on a chair with wheels.

Leg Med (Tokyo) 2019 02 3;36:81-84. Epub 2018 Nov 3.

Department of Forensic Medicine, Graduate School of Biomedical Sciences, Tokushima University, Japan.

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http://dx.doi.org/10.1016/j.legalmed.2018.11.001DOI Listing
February 2019

Forensic microbiology applications: A systematic review.

Leg Med (Tokyo) 2019 Feb 3;36:73-80. Epub 2018 Nov 3.

Legal Medicine Section - Department for Health Promotion and Mother-Child Care, University of Palermo, Via del Vespro, 129, 90127, Italy. Electronic address:

According to the Human Microbiome Project (HMP), a healthy human body contains ten times more microbes than human cells. Microbial communities colonize different organs of the body, playing fundamental roles both in human health and disease. Despite the vast scientific knowledge of the role of microbial communities in a living body, little is known at present about microbial changes occurring after death, thus leading many authors to investigate the composition of the thanatomicrobiome and its potential applications in the forensic field. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.002DOI Listing
February 2019
11 Reads

Na/K-ATPase, acetylcholinesterase and glutathione S-transferase activities as new markers of postmortem interval in Swiss mice.

Leg Med (Tokyo) 2019 Feb 3;36:67-72. Epub 2018 Nov 3.

Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), CEP 96010-900 Pelotas, RS, Brazil. Electronic address:

Determining precisely the postmortem interval (PMI) is a key parameter for forensic researches, given that various physical, biochemical and metabolic changes begin to occur in the body after death. In the present study, the Na/K-ATPase, glutathione S-transferase (GST) and acetylcholinesterase (AChE) activities were evaluated. For this, male adult Swiss mice were killed by isoflurane inhalation anesthesia and divided into four groups according to time of death (0, 6, 24 and 48 h). Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.11.003DOI Listing
February 2019
11 Reads

Quantification of secondary dentin formation based on the analysis of MDCT scans and dental OPGs in a contemporary Malaysian population.

Leg Med (Tokyo) 2019 02 3;36:59-66. Epub 2018 Nov 3.

Centre for Forensic Anthropology, M420, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.

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http://dx.doi.org/10.1016/j.legalmed.2018.11.004DOI Listing
February 2019
1 Read

Dental age estimation in Malaysian adults based on volumetric analysis of pulp/tooth ratio using CBCT data.

Leg Med (Tokyo) 2019 Feb 21;36:50-58. Epub 2018 Oct 21.

Department of Dental Research Management Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Forensic odontology plays an important role in human identification and dental age estimation is an integral part of this process. The aim of the study was to investigate the association between chronological age and pulp/tooth volume ratio in a Malaysian population (Malays and Chinese) from cone-beam computed tomography (CBCT) scans, enhanced with Mimics software. Three hundred CBCT scans of 153 males and 147 females, aged between 16 and 65 years were divided into 5 age groups. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.10.005DOI Listing
February 2019
11 Reads

Pathology diagnosis of an atypical thyroid cartilage lesion.

Leg Med (Tokyo) 2019 Feb 19;36:47-49. Epub 2018 Oct 19.

CHU Poitiers, Département de médecine légale, IML/UMJ, Poitiers, France; Univ Poitiers, Faculté de médecine et de pharmacie, Poitiers, France.

In forensic practice, laryngeal lesions are of particular interest for the pathologist, as they may sign foul play. We report the case of a decedent, whose body was found in an advanced state of putrefaction, at the bottom of a ledge, after a one-month disappearance. The face and neck were skeletised. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.10.003DOI Listing
February 2019
7 Reads

Undetected severe complication after elective lumbar surgery - How could it happen?

Leg Med (Tokyo) 2019 02 19;36:43-46. Epub 2018 Oct 19.

Department of Legal Medicine, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1016/j.legalmed.2018.10.004DOI Listing
February 2019

Genetic polymorphisms of 20 STR loci in a Chaoshan group from Jieyang, China.

Leg Med (Tokyo) 2019 Feb 1;36:41-42. Epub 2018 Oct 1.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

We obtained allelic frequencies and forensic parameters of 20 short tandem repeat (STR) loci (D3S1358, FGA, D5S818, D7S820, CSF1PO, D16S539, D19S433, vWA, D8S1179, D18S51, D13S317, TPOX, TH01, D2S1338, D12S391, D1S1656, D21S11, D6S1043, Penta D, Penta E) from 529 unrelated individuals in Jieyang Han population using PowerPlex® 21 (Promega, Madison, Wi, USA). The relationship between the Jieyang Han group and other Han populations was studied and the results showed that the Jieyang Han population had the closest genetic relationship with the Fujian Han population. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.016DOI Listing
February 2019
6 Reads
1.440 Impact Factor

Autopsy case of right ventricular rhabdomyoma in tuberous sclerosis complex.

Leg Med (Tokyo) 2019 Feb 9;36:37-40. Epub 2018 Oct 9.

Medical Examiner's Office of Hyogo Prefecture, Kobe, Japan; Department of Forensic Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder characterized by widespread hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung, and liver. Rhabdomyoma is the most common cardiac tumor diagnosed in fetuses, neonates and infants, and is closely linked to TSC. Here we describe an autopsy case of right ventricular rhabdomyoma in TSC. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.10.001DOI Listing
February 2019
12 Reads

An experimental study on investigating the postmortem interval in dichlorvos poisoned rats by GC/MS-based metabolomics.

Leg Med (Tokyo) 2019 Feb 11;36:28-36. Epub 2018 Oct 11.

West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:

The estimation of the postmortem interval (PMI) is always a key issue in forensic science. Although many attempts based on metabolomics approaches have been proven to be feasible and accurate for PMI estimation, there have been no reports regarding the determination of the PMI in acute dichlorvos (DDVP) poisoning. In this study, all rats were killed by acute DDVP poisoning at a dose three fold the oral LD (240 mg/kg). Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.10.002DOI Listing
February 2019

Traumatic axonal injury revealed by postmortem magnetic resonance imaging: A case report.

Leg Med (Tokyo) 2019 Feb 1;36:9-16. Epub 2018 Oct 1.

Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

In forensic investigations, it is important to detect traumatic axonal injuries (TAIs) to reveal head trauma that might otherwise remain occult. These lesions are subtle and frequently ambiguous on macroscopic evaluations. We present a case of TAI revealed by pre-autopsy postmortem magnetic resonance imaging (PMMR). Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.019DOI Listing
February 2019
3 Reads

Association between sudden unexpected deaths in bathtubs and ambient temperature among elderly Japanese adults: A time-series regression study.

Leg Med (Tokyo) 2019 Feb 3;36:21-27. Epub 2018 Oct 3.

Department of Legal Medicine, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo 113-8602, Japan; Tokyo Medical Examiner's Office, Tokyo Metropolitan Government, Bunkyo-ku, Tokyo, Japan. Electronic address:

Background: Sudden unexpected deaths in bathtubs among elderly Japanese adults occur predominantly during the cold season. This study investigated the relationship between these deaths and bathing day temperature among elderly adults in Tokyo.

Methods: Data for 1408 cases of bath-related deaths from January 1 to December 31, 2015 were obtained from the Tokyo Medical Examiner's Office. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.021DOI Listing
February 2019
6 Reads

Association of SNPs in transferrin and transferrin receptor genes with blood iron levels in human.

Leg Med (Tokyo) 2019 Feb 4;36:17-20. Epub 2018 Oct 4.

Department of Legal Medicine, Shimane University School of Medicine, Izumo 693-8501, Japan.

Iron is bound to mobile transferrin (TF) and ferritin in blood. TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm. In this study, we examined the effects of 10 single nucleotide polymorphisms (SNPs) in each of the genes for TF and TF receptors on blood iron concentrations in Japanese subjects. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.022DOI Listing
February 2019
1 Read

A quantitative morphological analysis of three-dimensional CT coxal bone images of contemporary Japanese using homologous models for sex and age estimation.

Leg Med (Tokyo) 2019 Feb 1;36:1-8. Epub 2018 Oct 1.

Division of Forensic Medicine, Department of Forensic Science, Iwate Medical University, Iwate 028-3694, Japan.

Sexual dimorphisms and age-dependent morphological features of the human coxal bone were quantitatively analyzed using homologous models created from three-dimensional (3D) computed tomography images of the pelvis (male: 514 samples, female: 388 samples, age 16-100). Bilateral average coxal images of each sex and age decade were generated separately through principle component analyses (PCA). By measuring average point-to-point distances of 8472 corresponding points (average corresponding point differences [ACPDs]) between each homologous coxal image and the average images, the sex of more than 93% of the samples was correctly assigned. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.017DOI Listing
February 2019
11 Reads

The evaluation of Oryza sativa L (Black rice) extracts for detection of spermatozoa on the clothing and vaginal swab samples.

Leg Med (Tokyo) 2018 Nov 2;35:91-97. Epub 2018 Oct 2.

Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Thailand; Department of Forensic Sciences, Faculty of Allied Health Sciences, Thammasat University, Thailand. Electronic address:

Investigation of sexual assault cases from the evidence involving vaginal swab, clothing and others is examined by a forensic scientist. The explanation of trace findings on spermatozoa on clothing is often problematic due to the use of different staining methods. Conventional staining method used either Papanicolaou (PAP) or Dip quick® stain as synthetic dyes which are expensive imported material and harmful to human health. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13446223183023
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http://dx.doi.org/10.1016/j.legalmed.2018.09.020DOI Listing
November 2018
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An autopsy report of accidental burial in a beach sand hole.

Leg Med (Tokyo) 2018 Nov 27;35:88-90. Epub 2018 Sep 27.

Department of Legal Medicine, Kyorin University School of Medicine, Japan. Electronic address:

We present a 23-year-old married couple who died by accidental burial in a beach sand hole. The victims fell into a hole that had been covered with a plastic sheet, and were buried suddenly by sand that had been piled on the top of the sheet. At autopsy, facial congestion; petechial hemorrhages in the conjunctivae and the oral mucosa; skin petechiae at the face, neck and upper chest; congestion and hemorrhages in the cervical lymph nodes; and some minor hemorrhages in the cervical muscles were found in both victims. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.013DOI Listing
November 2018
12 Reads

Trimethylamine in postmortem tissues as a predictor of postmortem interval estimation using the GC method.

Leg Med (Tokyo) 2018 Nov 22;35:80-85. Epub 2018 Sep 22.

Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, China. Electronic address:

Trimethylamine (TMA), a simple amine in volatile compounds, indicating the spoilage degree of meat, related with the late postmortem interval (PMI) during the cadaver decomposition process. In this paper, a headspace gas chromatography (HS-GC) method has been successfully built to analyze the content of TMA in postmortem rat tissues (liver, myocardial and skeletal muscle tissues), which is used for PMI estimation with the wide range of PMI (0-720 h postmortem) at 16 °C ± 1 °C. Correspondingly, three equations about the relationship between the PMI and TMA content were established, in which they showed that the TMA content in all three tissues increased from the firstly detected time to 192 h and gradually decreased after 384 h. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.011DOI Listing
November 2018
2 Reads

DNA analysis of hairs in a suspected case of child abuse.

Leg Med (Tokyo) 2018 Nov 22;35:77-79. Epub 2018 Sep 22.

Department of Disaster Relief Medicine, Division of Forensic Dentistry, Kanagawa Dental University Graduate School of Dentistry, 82 Inaokacho, Yokosuka, Japan.

Hairs are often used for DNA analysis in criminal investigations. DNA analysis of hairs with root sheaths is easy in many cases, but analyses using only the shaft or tip of the hair are often difficult. Here we describe a suspected case of child abuse in which we were commissioned to perform DNA analysis. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.010DOI Listing
November 2018
3 Reads

Two loci concurrent mutations in non-exclusion parentage cases using 19 STR profiles.

Leg Med (Tokyo) 2018 Nov 24;35:73-76. Epub 2018 Sep 24.

Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, China; Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, China. Electronic address:

Two loci concurrent mutations in non-exclusion paternity case were reported based on 19 STR loci available from Goldeneye™ DNA ID System 20A (Peoplespot, Beijing, China). When 9508 family trios with Paternity index (PI) threshold of >10,000 was analyzed, 14 families show mutations at two loci. The paternity was confirmed by using an additional 19 STR markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13446223173042
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http://dx.doi.org/10.1016/j.legalmed.2018.09.012DOI Listing
November 2018
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Comparison of postmortem butane distribution between two fatal butane poisoning cases.

Leg Med (Tokyo) 2018 Nov 26;35:69-72. Epub 2018 Sep 26.

Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Fatal accidents during butane abuse frequently occur in Japan and in many countries around the world. Although analytical data about butane concentration in postmortem samples is being accumulated, when using the data to determine the cause of death, careful interpretation is required because the gas is easily diffused. Two fatal butane poisoning cases were encountered, and butane quantification of autopsy samples obtained from left and right heart blood, femoral blood, kidney, liver, lung, brain and fatty tissues was performed. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.008DOI Listing
November 2018
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Left cerebral hemisphere hydrophilic polymer embolism associated with endovascular WEB treatment of a ruptured aneurysm of the anterior cerebral artery.

Leg Med (Tokyo) 2018 Nov 24;35:66-68. Epub 2018 Sep 24.

Department of Biomedicine, Pathology and Forensic Medicine, University of Turku, Turku, Finland; Department of Forensic Medicine, University of Oulu, Oulu, Finland. Electronic address:

Hydrophilic polymer embolism (HPE) is a rare, likely under-recognized iatrogenic complication, caused by fragmentation of surface materials used on endovascular medical devices. The organs most often involved in HPE are the brain and lungs, resulting in both local and systemic reactions. We present the case of a cerebral HPE associated with WEB treatment of a ruptured aneurysm of the anterior cerebral artery, and involving diffusely the left cerebral hemisphere. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.015DOI Listing
November 2018
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Lung weight estimation with postmortem CT in forensic cases.

Leg Med (Tokyo) 2018 Nov 22;35:61-65. Epub 2018 Sep 22.

Faculty of Health Science, Core Research Lab., Hokkaido University, Japan. Electronic address:

Postmortem computed tomography (CT) is a minimally invasive technique to examine internal organs before a forensic autopsy. The purpose of our study was to estimate lung weight in a forensic setting in cases of various lung states, including fluid accumulation (congestion, edema, hypostasis, and inflammation etc.) using postmortem CT. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.007DOI Listing
November 2018
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Sex estimation by size and shape of foramen magnum based on CT imaging.

Leg Med (Tokyo) 2018 Nov 22;35:50-60. Epub 2018 Sep 22.

Department of Anatomy and Histology, Medical University of Sofia, 1431 Sofia, Bulgaria; Department of Synaptic Signaling and Communications, Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

Foramen magnum (FM) has a well-protected position, which makes it of particular interest in forensic research. The aim of the study is to assess the sex differences in size and shape of FM, develop discriminant functions and logistic regression models based on the FM measurements, compare the accuracy results of the measurements obtained through different measuring approaches, and establish the most reliable variables for sex estimation in Bulgarian adults. Head CT scans of 140 Bulgarian adults were used in the study. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.009DOI Listing
November 2018
1 Read
1.441 Impact Factor

A case of intoxication with a mixture of synthetic cannabinoids EAM-2201, AB-PINACA and AB-FUBINACA, and a synthetic cathinone α-PVP.

Leg Med (Tokyo) 2018 Nov 6;35:44-49. Epub 2018 Aug 6.

Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

We report a case of intoxication with a mixture of three synthetic cannabinoids and a synthetic cathinone, which have been disclosed by a highly sensitive progressing technology. A man was found dead, and his forensic autopsy was performed at our department. After further examinations of his specimens, EAM-2201 and α-PVP have been newly found in his lung. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.08.004DOI Listing
November 2018
10 Reads

Environmental microbiology: Perspectives for legal and occupational medicine.

Leg Med (Tokyo) 2018 Nov 24;35:34-43. Epub 2018 Sep 24.

Carabinieri, Reparto Investigazioni Scientifiche di Roma, V.le di Tor di Quinto, 119, 00191 Roma, Italy. Electronic address:

The analysis of microorganism population is crucial in several medical fields. This is especially true in legal and occupational medicine, where the specialist can be asked to perform an evaluation of several environmental matrices. In these two medical fields an accurate microbiological analysis is part of a wide process aimed to the definition of the interactions between human beings and environment. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.014DOI Listing
November 2018

Assessment of DNA degradation of buccal cells under humid conditions and DNA repair by DOP-PCR using locked nucleic acids.

Leg Med (Tokyo) 2018 Nov 10;35:29-33. Epub 2018 Sep 10.

Department of Legal Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan.

We analyzed the degradation level of DNA from buccal cells under humid conditions using quantitative PCR analysis. Gauze samples with buccal cells were incubated for up to 12 months under three different conditions (25 °C/dry, 25 °C/humid, or 40 °C/humid). The degradation was evaluated based on two degradation ratios (129:41 and 305:41 bp). Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.005DOI Listing
November 2018

Sudden unexpected death with primary adrenal lymphoma.

Leg Med (Tokyo) 2018 Nov 12;35:25-28. Epub 2018 Sep 12.

Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. Electronic address:

An 82-year-old man was found dead on the road near his home with unwitnessed interval of 3 h from final witness. He had been diagnosed with hypertension and mild aortic stenosis (AS) 13 years before death, and was continuously followed up with medication. Although a recent medical check-up related to cardiac function was stable and consistent with moderate AS, he sometimes complained of general fatigue, anorexia associated with intermittent mild fever and rare vomiting in the weeks before death. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.001DOI Listing
November 2018
15 Reads

Early postmortem interval estimation based on Cdc25b mRNA in rat cardiac tissue.

Leg Med (Tokyo) 2018 Nov 10;35:18-24. Epub 2018 Sep 10.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, 131Dongan Road, Shanghai 200032, China. Electronic address:

Purpose: The postmortem interval (PMI) is the amount of time that has elapsed since the time of death. Over the years, many approaches have been developed to assess PMI, but their time frame of applicability has been only days to weeks. Our present pilot study aimed to find the sensitive mRNA marker if the degradation of mRNA could be used to estimate the early postmortem interval (up to 24 h). Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.09.004DOI Listing
November 2018
4 Reads

Fatal exertional rhabdomyolysis. Literature review and our experience in forensic thanatology.

Leg Med (Tokyo) 2018 11 10;35:12-17. Epub 2018 Sep 10.

Department of Advanced Biomedical Sciences, Legal Medicine Unit, University of Naples Federico II, Via Pansini 5, Edificio 20, 1° piano, 80131 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.legalmed.2018.09.003DOI Listing
November 2018