372 results match your criteria Lead Poisoning Imaging


bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis.

IDCases 2022 6;29:e01525. Epub 2022 Jun 6.

Infectious Disease Division, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA.

() is a known cause of a food poisoning in the general population. However, it can cause life-threatening sepsis and shock in severely immunocompromised patients with hematologic malignancies, which frequently lead to central nervous system (CNS) infections associated with high mortality and morbidity. In this case report, we describe a patient with a newly diagnosed acute myeloid leukemia that underwent induction chemotherapy and developed infection that was associated with septic shock and brain abscesses. Read More

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Reversal of genetic brain iron accumulation by N,N'-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice.

Arch Toxicol 2022 Jul 21;96(7):1951-1962. Epub 2022 Apr 21.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.

N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a novel lipophilic metal chelator and antioxidant used in mercury poisoning. Recent studies have suggested that NBMI may also bind to other metals such as lead and iron. Since NBMI can enter the brain, we evaluated if NBMI removes excess iron from the iron-loaded brain and ameliorates iron-induced oxidative stress. Read More

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And the Oscar Goes to Peripheral Blood Film for the Detection of Lead Poisoning in a Complicated Toxic Patient: A Case Report with a Review of Laboratory Clues.

Case Rep Med 2022 23;2022:9238544. Epub 2022 Feb 23.

Department of Pathology, Shiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Peripheral blood smear examination is an invaluable laboratory test, which provides the complete hematologic and/or nonhematologic picture of a case. In addition to verifying the results of automated cell counters, it has the potential to identify some pathologic and morphologic changes that remain hidden using the cell counters alone. . Read More

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February 2022

[Severe lead poisoning caused by ayurvedic medicine].

Dtsch Med Wochenschr 2022 Mar 28;147(5):253-257. Epub 2022 Feb 28.

Klinik II für Innere Medizin: Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Medizinische Fakultät und Uniklinik Köln, Universität zu Köln.

History:  We report the case of a young patient who presented to our emergency department with reduced general condition, anemia, and crampy abdominal pain. A previous inpatient workup including abdominal imaging and bone marrow aspiration had not yielded a diagnosis. On inquiry, the patient reported oral ingestion of an Ayurvedic remedy over the course of one month. Read More

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Man With Chronic Foot Pain.

Ann Emerg Med 2022 03;79(3):249-269

Division of Musculoskeletal Radiology, Department of Radiology, University of California, San Diego.

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Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report.

BMC Pediatr 2022 01 17;22(1):43. Epub 2022 Jan 17.

Department of Pediatrics, Linyi People's Hospital, Linyi, 276000, Shandong Province, China.

Background: It is common for children to accidentally ingest chemical drugs with different degrees of toxicity. Meperfluthrin is a highly effective and easy-to-use pyrethroid pesticide with low toxicity. It is widely used in electric mosquito coils. Read More

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January 2022

The Blood Lead Levels of Children and the Loss of Ca from Neurons Owing to Lead.

Int J Environ Res Public Health 2021 11 17;18(22). Epub 2021 Nov 17.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

In order to understand current blood lead levels (BLLs), we investigated the BLLs of children in Sichuan Province from 2011 to 2020. We then monitored the treatment effects of calcium in children with high BLLs to assess their treatment status. Finally, we explored the effects of lead on Ca through in-situ experiments. Read More

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November 2021

Lead Encephalopathy with Distinctive Brain Magnetic Resonance Imaging Findings.

Neurol India 2021 Sep-Oct;69(5):1421-1423

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Lead poisoning is a multisystem disorder, more commonly affecting children. Occupational exposure, traditional medicines, and contaminated alcohol have been associated with lead encephalopathy in adults. Herein, we report a patient of lead toxicity presenting to the emergency services as acute encephalopathy with symptomatic hyponatremia and chronic recurrent abdominal colic and vomiting. Read More

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November 2021

Versatile Cell and Animal Models for Advanced Investigation of Lead Poisoning.

Biosensors (Basel) 2021 Oct 4;11(10). Epub 2021 Oct 4.

National Biotechnology Research Park, LumiSTAR Biotechnology Inc., Taipei City 115, Taiwan.

The heavy metal, lead (Pb) can irreversibly damage the human nervous system. To help understand Pb-induced damage, we applied a genetically encoded Förster resonance energy transfer (FRET)-based Pb biosensor Met-lead 1.44 M1 to two living systems to monitor the concentration of Pb: induced pluripotent stem cell (iPSC)-derived cardiomyocytes as a semi-tissue platform and fruit flies as an in vivo animal model. Read More

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October 2021

Specific recognition, intracellular assay and detoxification of fluorescent curcumin derivative for copper ions.

J Hazard Mater 2021 10 25;420:126490. Epub 2021 Jun 25.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Recognition and excretion of metal ions play an important role in the diagnosis and treatment of various diseases and poisoning. Although copper (Cu) is a cofactor of many key enzymes in the human body, its accumulation caused by genetic ATP7B mutation or environmental pollution can lead to hepatotoxicity, renal failure, Wilson's disease, inflammation, and even Parkinson's disease (PD) and Alzheimer's disease (AD). Therefore, in this work, a difluoroboron curcumin derivative (DF-Cur) was used for the specific recognition of copper ions (Cu). Read More

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October 2021

Lead poisoning induced by gunshot injury with retained bullet fragments.

Authors:
J-S Yen T-H Yen

QJM 2022 Jan;114(12):873-874

Department of Nephrology, Clinical Poison Center, Chang Gung Memorial Hospital, Linkou 333, Taiwan.

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January 2022

Development of delayed neurologic sequelae in acute carbon monoxide poisoning cases caused by briquette-based kotatsu: A case-control study.

Medicine (Baltimore) 2021 Apr;100(16):e25009

Department of Emergency and Critical Care Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan.

Abstract: Briquette-based kotatsu, a traditional Japanese heating system, is still used in rural areas and has been linked to the development of acute carbon monoxide (CO) poisoning. This study aimed to investigate the occurrence of delayed neurologic sequelae (DNS) in patients with acute CO poisoning caused by briquette-based kotatsu.This retrospective study included 17 patients treated for acute CO poisoning due to briquette-based kotatsu, between April 2017 and March 2020. Read More

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Analysis of lead distribution in avian organs by LA-ICP-MS: Study of experimentally lead-exposed ducks and kites.

Environ Pollut 2021 Aug 5;283:117086. Epub 2021 Apr 5.

Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.

Lead poisoning of wild birds by ingestion of lead ammunition occurs worldwide. Histopathological changes in organs of lead-intoxicated birds are widely known, and lead concentration of each organ is measurable using mass spectrometry. However, detailed lead localization at the suborgan level has remained elusive in lead-exposed birds. Read More

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Altered functional activations of prefrontal brain areas during emotional processing of fear in Inuit adolescents exposed to environmental contaminants.

Neurotoxicol Teratol 2021 May-Jun;85:106973. Epub 2021 Mar 16.

Département de Psychologie, Université du Québec à Montréal, Montréal, Québec, Canada; Research Centre of CHU Ste-Justine, Montréal, Québec, Canada. Electronic address:

Exposure to mercury, lead and polychlorinated biphenyls (PCBs) have been associated with emotional dysregulation, but their neuronal correlates have yet to be examined. Inuit from Nunavik (Northern Quebec, Canada) face internalizing problems and are among the most exposed individuals to these environmental contaminants in the world. The aim of this study was to examine the link between pre- and postnatal exposure to these contaminants and brain fear-circuitry in Inuit adolescents. Read More

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December 2021

Near-infrared light excited UCNP-DNAzyme nanosensor for selective detection of Pb and in vivo imaging.

Talanta 2021 May 29;227:122156. Epub 2021 Jan 29.

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China. Electronic address:

Due to similar charges, atomic radii, and chemical properties of most metal ions, the selective sensing of these metal ions and imaging in vivo is still a challenge. A DNAzyme assemblied and near-infrared (NIR) light excited nanosensor was developed to detect and image Pb. In this nanosensor, NaYF:Yb, Er upconversion nanoparticles (UCNPs) introduced as NIR-to-Vis transducer were the donor of luminescence resonance energy transfer (LRET), and DNAzyme-functionalized black hole quencher 1 (BHQ1) acted as energy transfer acceptor. Read More

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Diagnosis and Treatment of Heavy Metal Toxicosis in Six Waldrapp Ibis ().

J Avian Med Surg 2020 Dec;34(4):371-380

Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield AL9 7TA, UK.

Six adult Waldrapp ibis () were presented with heavy metal toxicosis secondary to paint chip ingestion after being placed in an indoor confinement enclosure because of a regional highly pathogenic avian influenza epornitic and government restrictions. Four of the ibis developed clinical disease signs between 45 and 64 days of confinement, including weakness, lethargy, inability to fly, low body condition, and bilateral wing droop while 2 birds appeared to remain normal during that period. Common clinicopathological findings included elevated plasma aspartate aminotransferase, creatine kinase, glutamate dehydrogenase, and bile acids values. Read More

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December 2020

Convulsive status epilepticus as the initial presentation of superwarfarin poisoning: a case report.

Ann Palliat Med 2021 Jun 22;10(6):7008-7012. Epub 2020 Oct 22.

Department of Neurology, First Hospital of Jilin University, Changchun, China; Department of Life Sciences, National Natural Science Foundation of China, Beijing, China.

Bromadiolone, a widely-used rodent control drug, could act as a long-acting anticoagulant. Patients of bromadiolone poisoning often present with multiorgan hemorrhage. However, neurological symptoms of bromadiolone poisoning are seldom reported. Read More

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Mothball ingestion as a manifestation of pica, leading to paradichlorobenzene CNS toxicity.

Afr Health Sci 2020 Jun;20(2):932-935

Department of Neurology, Albert Einstein Medical Center, Philadelphia PA, USA.

Background: Pica is a poorly understood psychiatric disorder that presents with the ingestion of non-nutritious substances for unclear reasons. A high index of suspicion for unusual toxin exposure aids in the diagnosis of pica patients presenting with unexplained neurodegenerative features.

Methods: We present a 47-year-old female with worsening gait over the past year. Read More

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Whole-brain R1 predicts manganese exposure and biological effects in welders.

Arch Toxicol 2020 10 1;94(10):3409-3420. Epub 2020 Sep 1.

School of Health Sciences, Purdue University, 550 Stadium Dr., Hampton Hall of Civil Engineering, West Lafayette, IN, 47907, USA.

Manganese (Mn) is a neurotoxicant that, due to its paramagnetic property, also functions as a magnetic resonance imaging (MRI) T1 contrast agent. Previous studies in Mn toxicity have shown that Mn accumulates in the brain, which may lead to parkinsonian symptoms. In this article, we trained support vector machines (SVM) using whole-brain R1 (R1 = 1/T1) maps from 57 welders and 32 controls to classify subjects based on their air Mn concentration ([Mn]), Mn brain accumulation (ExMn), gross motor dysfunction (UPDRS), thalamic GABA concentration (GABA), and total years welding. Read More

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October 2020

Severe neurological nicotine intoxication by e-cigarette liquids: Systematic literature review.

Acta Neurol Scand 2021 Feb 20;143(2):121-130. Epub 2020 Sep 20.

Neurophysiopathology Unit, Neuromuscolar Department, AOU Careggi, Florence, Italy.

Electronic cigarettes are a popular, easily purchased, alternative source of nicotine that is considered safer than conventional tobacco. However, Intentional or accidental exposure to e-liquid substances, mainly nicotine, can lead to serious, potentially fatal toxicity. Emergency and critical care physicians should keep in mind acute intoxication of this poison with a biphasic toxic syndrome. Read More

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February 2021

Colchicine poisoning complicated by medulla oblongata myelinolysis: a case report.

Ann Palliat Med 2021 Feb 25;10(2):2349-2353. Epub 2020 May 25.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Medulla oblongata myelinolysis is an extremely rare manifestation of extrapontine myelinolysis (EPM). Herein, we report a case of a 34-year-old man with a history of gout who presented repeated vomiting and diarrhea after ingesting 15 colchicine pills. A hyponatremia diagnosis was given and after an intensive treatment, his serum sodium level increased from 118 to 129 mmol/L within 24 hours. Read More

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February 2021

Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature.

Indian J Crit Care Med 2020 Mar;24(3):203-205

Department of Pharmacology, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Aim: To determine the significance of acute disulfiram poisoning in pediatric population.

Background: Disulfiram poisoning in children is uncommon, can occur in children who have ingested large amount of drug because of careless and unsafe storage. Only few cases have been reported in literature. Read More

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Diagnostic utility of arterial spin labeling in identifying changes in brain perfusion in patients with carbon monoxide poisoning.

Clin Imaging 2020 Aug 11;64:92-96. Epub 2020 Apr 11.

Department of Emergency Medicine, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey.

Objective: Carbon monoxide (CO) poisoning is one of the most common poisonings worldwide. The affinity of hemoglobin for CO is significantly higher than that for oxygen, and the formation of carboxy-hemoglobin leads to a decrease in the capacity of blood to transport oxygen to tissues, tissue hypoxia, and early perfusion changes in the affected tissue. This study aimed to investigate the utility of arterial spin labeling perfusion imaging (ASL-PI) in revealing cerebral vascular hemodynamic changes in patients presenting to the emergency room with CO poisoning and to compare findings with those from diffusion-weighted imaging (DWI). Read More

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Encephalopathy following ingestion of Lead-contaminated opium; magnetic resonance imaging findings.

BMC Neurol 2020 May 1;20(1):166. Epub 2020 May 1.

Department of Neurology, Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Encephalopathy is an uncommon but serious presentation of lead toxicity.

Objective: We aimed to determine and follow-up the brain magnetic resonance imaging (MRI) abnormalities in the patients with lead encephalopathy due to ingestion of lead contaminated opium.

Methods: In a cross-sectional study during lead-contaminated opium outbreak, all lead-poisoned patients with any signs/symptoms of encephalopathy were included. Read More

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Pseudotumor Caused by a Retained Intra-articular Bullet: A Case Report.

JBJS Case Connect 2020 Jan-Mar;10(1):e0209

Department of Orthopaedic Surgery, University of California San Francisco-Fresno, Fresno, California.

Case: A 54-year-old man presented with systemic lead poisoning due to a gunshot wound to the hip suffered 35 years prior to presentation. He urgently underwent removal of the bullet with total hip arthroplasty and was found to have a pseudotumor. This case highlights the team-based approach to manage systemic lead poisoning caused by an intra-articular bullet. Read More

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January 2021

Imaging methods used in the assessment of environmental disease networks: a brief review for clinicians.

Insights Imaging 2020 Feb 7;11(1):18. Epub 2020 Feb 7.

Directorate of Research, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.

Background: Across the globe, diseases secondary to environmental exposures have been described, and it was also found that existing diseases have been modified by exposure to environmental chemicals or an environmental factor that has been found in their pathogenesis. The Institute of Medicine has shared a permanent concern related to the nations environmental health capacity since 1988.

Main Body: Contemporary imaging methods in the last 15 years started reporting alterations in different human systems such as the central nervous system, cardiovascular system and pulmonary system among others; evidence suggests the existence of a human environmental disease network. Read More

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February 2020

Transient ST Segment Elevation Caused by Intracoronary Thrombus after Acute Carbon Monoxide Poisoning.

Prehosp Disaster Med 2019 Dec 9;34(6):677-680. Epub 2019 Oct 9.

Eskisehir State Hospital, Department of Cardiology, Eskişehir, Turkey.

Carbon monoxide (CO) poisoning is the most common cause of death and injury among all poisonings. Myocardial injury is detected in one-third of CO poisonings. In this Case Report, a previously healthy 41-year-old man was referred for CO poisoning. Read More

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December 2019

The Design and Application of an Appropriate Parkinson's Disease Animal Model in Regenerative Medicine.

Adv Exp Med Biol 2021 ;1341:89-105

Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Aging as an inevitable and complex physiological process occurs through a progressive decrease in the potential of tissue regeneration. Given the increasing global outbreak of aging and age-related disorders, it is important to control this phenomenon. Parkinson's disease (one of the age-related neurodegenerative and progressive disorders) resulted from predominant dopaminergic neurons deficiency. Read More

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Management of Ingested Lead Pellets With Elevated Blood Lead Levels in a Pediatric Patient.

J Pediatr Gastroenterol Nutr 2019 12;69(6):e159-e160

Division of Pediatric Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA.

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December 2019

Lead poisoning due to ingestion of lead-contaminated opium: A diagnostic study on patients' imaging findings.

J Trace Elem Med Biol 2019 Sep 25;55:26-32. Epub 2019 Apr 25.

Washington Poison Center, Seattle, WA, USA.

Objectives: Our study attempts to determine if for patients following ingestion of lead-contaminated opium, radiographs [plain X-ray (KUB)] or unenhanced computed tomography (CT scan) of the abdomen may be predictive of lead poisoning.

Methods: Our study is concerned with patients of >21 years with elevated lead concentrations, who had undergone KUB or CT. Patients with other toxicities who had undergone similar imaging profiles but who had low blood lead level (BLL) were enrolled as controls. Read More

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September 2019