Arch Toxicol 2020 10 1;94(10):3409-3420. Epub 2020 Sep 1.
School of Health Sciences, Purdue University, 550 Stadium Dr., Hampton Hall of Civil Engineering, West Lafayette, IN, 47907, USA.
Manganese (Mn) is a neurotoxicant that, due to its paramagnetic property, also functions as a magnetic resonance imaging (MRI) T1 contrast agent. Previous studies in Mn toxicity have shown that Mn accumulates in the brain, which may lead to parkinsonian symptoms. In this article, we trained support vector machines (SVM) using whole-brain R1 (R1 = 1/T1) maps from 57 welders and 32 controls to classify subjects based on their air Mn concentration ([Mn]), Mn brain accumulation (ExMn), gross motor dysfunction (UPDRS), thalamic GABA concentration (GABA), and total years welding. Read More