331 results match your criteria Lead Poisoning Imaging


Isoniazid Poisoning: A Pediatric Simulation Case for Emergency Medicine Residents.

MedEdPORTAL 2016 Dec 9;12:10515. Epub 2016 Dec 9.

Assistant Residency Director, Department of Emergency Medicine, Emory University School of Medicine; Assistant Professor of Emergency Medicine, Emory University School of Medicine.

Introduction: Seizures in the setting of isoniazid (abbreviated INH, from isonocotinylhydrazide) toxicity can be intractable and persistent despite treatment with the usual status epilepticus (SE) medications. If not recognized in a timely fashion, SE can lead to significant morbidity and mortality. This simulation scenario instructs emergency medicine and pediatric residents and fellows in any year of training on the principles and management strategies of approaching a pediatric patient with SE due to INH toxicity. Read More

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https://www.mededportal.org/publication/10515
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http://dx.doi.org/10.15766/mep_2374-8265.10515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440414PMC
December 2016
1 Read

[Lead intoxication revealing sickle cell disease].

Pan Afr Med J 2018 31;30:305. Epub 2018 Aug 31.

Service de Rhumatologie, CHU Mohammed VI, BP 2360 principal, Avenue Ibn Sina, Marrakech, Maroc.

We here report the case of a 18 year old patient with two brothers who died from sickle cell anemia. He had a 5-day history of diffuse bone pain. He had drunk a preparation containing lead to obtain an analgesic effect without improvement. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.305.16222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320453PMC
January 2019
2 Reads

Lead Toxicity from a Retained Bullet.

N Engl J Med 2018 Dec;379(25):2451

John H. Stroger Hospital of Cook County, Chicago, IL

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http://www.nejm.org/doi/10.1056/NEJMicm1804726
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http://dx.doi.org/10.1056/NEJMicm1804726DOI Listing
December 2018
9 Reads

Characterization and imaging of lead distribution in bones of lead-exposed birds by ICP-MS and LA-ICP-MS.

Chemosphere 2018 Dec 31;212:994-1001. Epub 2018 Aug 31.

Laboratory of Toxicology, Department of Environmental Veterinary Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo, Kita18, Nishi9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan. Electronic address:

Lead (Pb) poisoning in raptors and water birds is a serious problem in many countries. However, only a small fraction of Pb poisoning has been detected in birds. Bone specimens may be useful indices of Pb exposure because bones contain ∼90% of the total Pb body burden. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183163
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http://dx.doi.org/10.1016/j.chemosphere.2018.08.149DOI Listing
December 2018
18 Reads

Franklin expedition lead exposure: New insights from high resolution confocal x-ray fluorescence imaging of skeletal microstructure.

PLoS One 2018 23;13(8):e0202983. Epub 2018 Aug 23.

Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

In the summer of 1845, under the command of Sir John Franklin, 128 officers and men aboard Royal Navy ships HMS Erebus and HMS Terror sailed into Lancaster Sound and entered the waters of Arctic North America. The goal of this expedition was to complete the discovery of a northwest passage by navigating the uncharted area between Barrow Strait and Simpson Strait. Franklin and his crew spent the first winter at Beechey Island, where three crewmen died and were buried. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107236PMC
February 2019
6 Reads

Pellets in the Eye: Cerebral Aneurysm and Encephalomyeloneuropathy as Presenting Syndromes.

J Stroke Cerebrovasc Dis 2018 Dec 3;27(12):3670-3672. Epub 2018 Aug 3.

Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences. Electronic address:

Lead poisoning following retained gunshot pellets resulting in recurrent episodes of encephalomyeloneuropathy is rare and association of intracranial aneurysm with lead poisoning is interesting. The case report describes about a 58-year ayurvedic doctor who was hospitalized for recurrent abdominal pain and limb weakness appearing spontaneously and improving in a few days to weeks. He had 20 such attacks in last 30 years starting at 25 years after the gunshot wound that resulted in retention of 2 lead pellets in his skull. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.018DOI Listing
December 2018
2 Reads

Evaluation Selenocysteine Protective Effect in Carbon Disulfide Induced Hepatitis with a Mitochondrial Targeting Ratiometric Near-Infrared Fluorescent Probe.

Anal Chem 2018 07 12;90(13):8108-8115. Epub 2018 Jun 12.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Centre for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai 264003 , China.

As important active sites of oxidoreductase in mitochondria, selenocysteine (Sec) takes the responsibility for cytoprotective effect and intracellular redox homeostasis. Carbon disulfide (CS) is a common solvent in industry, which can inhibit the activities of oxidoreductase and induce oxidative stress. It is necessary to investigate the cytoprotective effect of Sec against CS exposure. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b01306DOI Listing
July 2018
23 Reads

Reduced regional volumes associated with total psychopathy scores in an adult population with childhood lead exposure.

Neurotoxicology 2018 07 7;67:1-26. Epub 2018 Apr 7.

Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Department of Radiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Childhood lead exposure has been correlated to acts of delinquency and criminal behavior; however, little research has been conducted to examine its potential long term influence on behavioral factors such as personality, specifically psychopathic personality. Neuroimaging studies have demonstrated that the effects of childhood lead exposure persist into adulthood, with structural abnormalities found in gray and white matter regions involved in behavioral decision making. The current study examined whether measurements of adult psychopathy were associated with neuroanatomical differences in structural brain volumes for a longitudinal cohort with measured childhood lead exposure. Read More

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http://dx.doi.org/10.1016/j.neuro.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054826PMC
July 2018
4 Reads

Lead in a case of encephalopathy.

BMJ Case Rep 2018 Mar 9;2018. Epub 2018 Mar 9.

Department of Paediatrics, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

A 2-year-old boy with a history of pica was admitted with vomiting and treated overnight for viral tonsillitis. A week later, he presented with a prolonged afebrile seizure and required intubation and ventilation. Antibiotics and acyclovir were started. Read More

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http://dx.doi.org/10.1136/bcr-2017-222388DOI Listing
March 2018
3 Reads

Extra-Articular Retained Missiles; Is Surveillance of Lead Levels Needed?

Mil Med 2018 03;183(3-4):e107-e113

Uniformed Services University-Walter Reed Department of Surgery, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889.

Background: Although gunshot wounds are relatively common, lead toxicity associated with extra-articular retained missiles (EARMs) is an uncommon, yet potentially devastating, complication. Although the risk of lead toxicity with intra-articular retained missiles is well known, EARMs are routinely left in situ or only removed in selected circumstances secondary to the relatively rare occurrence of complications.

Methods: We first describe a patient with systemic lead poisoning associated with retained lead fragments after a gunshot-induced left femoral shaft fracture. Read More

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http://dx.doi.org/10.1093/milmed/usx076DOI Listing
March 2018
2 Reads

Lead Poisoning: Myoclonus Following Welding Exposure.

Acta Med Port 2017 12 29;30(12):889. Epub 2017 Dec 29.

Instituto de Epilepsia y Parkinson del Eje Cafetero SA. Pereira. Colombia.

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http://dx.doi.org/10.20344/amp.9398DOI Listing
December 2017
7 Reads

From the Cover: 7,8-Dihydroxyflavone Rescues Lead-Induced Impairment of Vesicular Release: A Novel Therapeutic Approach for Lead Intoxicated Children.

Toxicol Sci 2018 01;161(1):186-195

Department of Environmental & Occupational Health, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida 33199.

Childhood lead (Pb2+) intoxication is a public health problem of global proportion. Lead exposure during development produces multiple effects on the central nervous system including impaired synapse formation, altered synaptic plasticity, and learning deficits. In primary hippocampal neurons in culture and hippocampal slices, Pb2+ exposure inhibits vesicular release and reduces the number of fast-releasing sites, an effect associated with Pb2+ inhibition of NMDA receptor-mediated trans-synaptic Brain-Derived Neurotrophic Factor (BDNF) signaling. Read More

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http://dx.doi.org/10.1093/toxsci/kfx210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837521PMC
January 2018
3 Reads

Feasibility of a portable X-ray fluorescence device for bone lead measurements of condor bones.

Sci Total Environ 2018 Feb 4;615:398-403. Epub 2017 Oct 4.

Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.

Lead based ammunition is a primary source of lead exposure, especially for scavenging wildlife. Lead poisoning remains the leading cause of diagnosed death for the critically endangered California condors, which are annually monitored via blood tests for lead exposure. The results of these tests are helpful in determining recent exposure in condors and in defining the potential for exposure to other species including humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697173246
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http://dx.doi.org/10.1016/j.scitotenv.2017.09.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688005PMC
February 2018
2 Reads

An Unusual Case of Acute Psychosis With Obsessive-Compulsive Features Following Arsenic Poisoning.

J Psychiatr Pract 2017 09;23(5):382-385

WU, ABDEL-GAWAD, and GHARBAOUI: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX TEIXEIRA, PIGOTT: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, and University of Texas Harris County Psychiatric Center, Houston, TX.

Arsenic exposure, particularly the chronic type, can lead to poisoning with manifestations presenting in multiple organ systems. However, acute psychosis is not a commonly described manifestation of arsenic exposure. In this report, we present the case of a patient who developed acute psychosis with hallucinations, disorganized thinking, and obsessive-compulsive symptoms following chronic occupational arsenic exposure. Read More

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http://dx.doi.org/10.1097/PRA.0000000000000254DOI Listing
September 2017
7 Reads

Skeletal Lead Burden of the British Royal Navy in Colonial Antigua.

Int J Osteoarchaeol 2017 Jul-Aug;27(4):672-682. Epub 2017 May 3.

Department of AnthropologyLakehead UniversityThunder BayONCanada.

Lead (Pb) has been known to be a cause of human poisoning since ancient times, but despite this, it was a widely used metal in the European colonial period. In this study, the relationship between Pb exposure and the demographic variables ancestry and age was explored by comparing the bone Pb levels of individuals that were of either African or European ancestry, excavated from a British Royal Navy hospital cemetery (1793-1822 CE) at English Harbour in Antigua, West Indies. More direct comparisons of Pb levels between the two ancestral groups were possible in this study because of the unsegregated nature of this cemetery. Read More

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http://dx.doi.org/10.1002/oa.2589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574018PMC
May 2017
4 Reads

Cognitive sequelae of lithium intoxication: a case report.

Int Psychogeriatr 2017 10 24;29(10):1747-1751. Epub 2017 Apr 24.

Department of Psychiatry,Psychosomatic Medicine and Psychotherapy,University Hospital Frankfurt/Goethe University,Frankfurt am Main,Germany.

Lithium intoxication is known to induce cognitive deficits along with motor and behavioral changes, even in association with normal serum levels. However, cases with comprehensive neuropsychological assessment of the deficits are rare. In our patient, we initially found severe cognitive deficits, including apraxia and visuo-constructive problems, and temporo-parietal FDG-PET hypometabolism. Read More

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http://dx.doi.org/10.1017/S1041610217000540DOI Listing
October 2017
4 Reads

Severe Systemic Lead Toxicity Resulting From Extra-Articular Retained Shrapnel Presenting as Jaundice and Hepatitis: A Case Report and Review of the Literature.

Mil Med 2017 03;182(3):e1843-e1848

Department of Preventive Medicine and Public Health, Blanchfield Army Community Hospital, 2576 23rd Street, Fort Campbell, KY 42223.

Introduction: Despite greater than 60,000 nonfatal firearm injuries per year in the United States, retained shrapnel is a relatively rare cause of systemic lead toxicity with less than 100 cases reported in the medical literature since 1867. While intra-articular retained shrapnel as a cause of lead toxicity is well-described, extra-articular fragments are less well known to cause symptomatic disease.

Case Report: A 31-year-old man initially presented with abdominal pain, constipation, jaundice, and elevated liver transaminases approximately 3 weeks after suffering a left lower extremity injury during athletic activity. Read More

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http://dx.doi.org/10.7205/MILMED-D-16-00231DOI Listing
March 2017
11 Reads

Severe lead toxicity attributed to bullet fragments retained in soft tissue.

BMJ Case Rep 2017 Mar 8;2017. Epub 2017 Mar 8.

University of Wisconsin-Madison, Wisconsin State Laboratory of Hygiene, Trace Element Research Laboratory, Madison, Wisconsin, USA.

A man aged 30 years presented to an emergency department with a 1 month history of severe abdominal pain, jaundice, constipation, lower extremity weakness and weight loss. A peripheral blood smear was performed that showed basophilic stippling of erythrocytes prompting a blood lead level (BLL) evaluation. The patient had a BLL of >200 µg/dL. Read More

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http://dx.doi.org/10.1136/bcr-2016-217351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353372PMC
March 2017
6 Reads

Abdominopelvic CT in a Patient With Seizure, Anemia, and Hypocalcemia.

Gastroenterology 2017 Jan 24;152(1):27-28. Epub 2016 Nov 24.

Toxciological Research Center, Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1053/j.gastro.2016.08.010DOI Listing
January 2017
2 Reads

Common Symptoms from an Uncommon Infection: Gastrointestinal Anisakiasis.

Can J Gastroenterol Hepatol 2016 9;2016:5176502. Epub 2016 Oct 9.

Division of Gastroenterology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON, Canada M5B 1W8.

Clinicians can be forgiven for thinking of anisakiasis as a rare condition low in the differential diagnosis of abdominal pain. Gastrointestinal anisakiasis is a zoonotic parasitic disease caused by consumption of raw or undercooked seafood infected with nematodes of the genus . Even though the reported cases indicate that this is a rare disease, the true incidence of the disease could be potentially higher than what is reported in the literature as cases can go undiagnosed. Read More

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http://dx.doi.org/10.1155/2016/5176502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075291PMC
March 2017
9 Reads

Systemic Lead Toxicity Secondary to Retained Intraosseous Bullet A Case Report and Review of Literature.

Bull Hosp Jt Dis (2013) 2016 Sep;74(3):229-33

A 35-year-old female presented to orthopaedic clinic with a chief complaint of chronic left hip pain, beginning 17 years prior when she had sustained a gunshot wound to her left buttock. Imaging demonstrated significant left hip arthritis with a retained projectile in the femoral head. Lead levels were also found to be significantly elevated. Read More

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September 2016
5 Reads

Proximal tubular nephropathy in two dogs diagnosed with lead toxicity.

Authors:
J B King

Aust Vet J 2016 Aug;94(8):280-4

Veterinary Specialist Services, Underwood, Queensland, Australia.

Case Report: Lead toxicity was diagnosed in two dogs presenting with vague clinical symptoms. Complete blood count, biochemical testing and imaging changes showed a metarubricytosis in dog 1, but were largely normal in dog 2. Both dogs had glucosuria and proteinuria on urinalysis consistent with damage to the proximal renal tubules. Read More

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http://dx.doi.org/10.1111/avj.12463DOI Listing
August 2016
3 Reads

Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.

Clin Neurol Neurosurg 2016 Aug 31;147:71-7. Epub 2016 May 31.

Department of Neurology, Lviv Regional Clinical Hospital, Ukraine.

Introduction: In the last fifteen years a new cause of chronic manganese toxicity has been recognized. It follows recreational intravenous injections of Ephedrone, synthesized from a cold remedies contained pseudoephedrine. Potassium permanganate is used as an oxidant. Read More

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http://dx.doi.org/10.1016/j.clineuro.2016.05.027DOI Listing
August 2016
15 Reads

Dietary supplement for energy and reduced appetite containing the β-agonist isopropyloctopamine leads to heart problems and hospitalisations.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2016 May 19;33(5):749-59. Epub 2016 Apr 19.

a RIKILT-Wageningen UR, Expertise Groups Biosensors & Bioassays and Contaminants & Toxins, WB , Wageningen , the Netherlands.

In 2013 the Dutch authorities issued a warning against a dietary supplement that was linked to 11 reported adverse reactions, including heart problems and in one case even a cardiac arrest. In the UK a 20-year-old woman, said to have overdosed on this supplement, died. Since according to the label the product was a herbal mixture, initial LC-MS/MS analysis focused on the detection of plant toxins. Read More

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https://www.tandfonline.com/doi/full/10.1080/19440049.2016.1
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http://dx.doi.org/10.1080/19440049.2016.1167965DOI Listing
May 2016
17 Reads

Correlation of brain Magnetic Resonance Imaging of spontaneously lead poisoned bald eagles (Haliaeetus leucocephalus) with histological lesions: A pilot study.

Res Vet Sci 2016 Apr 23;105:236-42. Epub 2016 Feb 23.

The Raptor Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, United States. Electronic address:

Six bald eagles with severe, acute lead poisoning based on blood lead values were analyzed by Magnetic Resonance Imaging (MRI) of the brain and histopathology. The aims of the study were to use MRI to locate brain lesions and correlate the changes in MRI signal with the histological character of the lesions at necropsy. All of the bald eagles presented with neurologic and non-neurologic signs suggestive of severe lead poisoning and had blood lead levels in excess of 1. Read More

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http://dx.doi.org/10.1016/j.rvsc.2016.02.010DOI Listing
April 2016
11 Reads

A rare case of self-injection of elemental mercury.

BMC Res Notes 2016 Mar 25;9:189. Epub 2016 Mar 25.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Self-injection of elemental mercury is a rare finding especially in healthy people who are mentally sound. Early detection and removal of mercury from the body by chelation and physical removal of a stored injected site is required to prevent long term toxicity.

Case Presentation: A 15 year old previously healthy girl presented with an acute febrile illness with a generalized maculopapular skin rash for 3 days with a preceding history of self-injection of mercury to both her forearms. Read More

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http://dx.doi.org/10.1186/s13104-016-1992-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807590PMC
March 2016
22 Reads

Acute Methanol Poisoning: Prevalence and Predisposing Factors of Haemorrhagic and Non-Haemorrhagic Brain Lesions.

Basic Clin Pharmacol Toxicol 2016 Aug 10;119(2):228-38. Epub 2016 Feb 10.

First Faculty of Medicine, Department of Occupational Medicine, Toxicological Information Center, Charles University in Prague and General University Hospital, Prague, Czech Republic.

The purpose was to study the prevalence and predisposing factors of brain lesions in survivors of acute methanol poisoning. Clinical data on 106 patients with methanol poisoning were collected during the Czech mass poisoning outbreak. Of 83 survivors, in 46 (55%) patients, follow-up examinations including magnetic resonance imaging of brain (MR) were performed 3-8 and 24-28 months after discharge from the hospital. Read More

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http://dx.doi.org/10.1111/bcpt.12559DOI Listing
August 2016
13 Reads

Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats.

J Biochem Mol Toxicol 2016 May 18;30(5):217-23. Epub 2016 Jan 18.

Department of Physiology, School of Medicine, Ege University, Izmir, Turkey.

Manganese (Mn) is a required element for biological systems; however, its excessive exposure may lead to a neurological syndrome known as manganism. The aim of the present study was to assess the toxic effects of subacute exposure of Mn by measuring weight gain, motor performance, and biochemical parameters (complex I activity, lipid peroxides, and protein carbonyls) in brain mitochondria in rats. We also examined whether edaravone (EDA), a radical scavenger, exerts protective effects against Mn-induced neurotoxicity. Read More

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http://dx.doi.org/10.1002/jbt.21780DOI Listing
May 2016
10 Reads

Carbon monoxide intoxication.

Handb Clin Neurol 2015 ;131:191-203

Center for Occupational and Environmental Neurology, Baltimore, MD, USA. Electronic address:

Carbon monoxide (CO) is a colorless, odorless, nonirritant gas that accounts for numerous cases of CO poisoning every year from a variety of sources of incomplete combustion of hydrocarbons. These include poorly functioning heating systems, indoor propane-powered forklifts, indoor burning of charcoal burning briquettes, riding in the back of pick-up trucks, ice skating rinks using propane-powered resurfacing machines, and gasoline-powered generators that are not in correct locations. Once CO is inhaled it binds with hemoglobin to form carboxyhemoglobin (COHb) with an affinity 200 times greater than oxygen that leads to decreased oxygen-carrying capacity and decreased release of oxygen to tissues leading to tissue hypoxia. Read More

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http://dx.doi.org/10.1016/B978-0-444-62627-1.00024-XDOI Listing
August 2016
9 Reads

Intranasal Fentanyl Intoxication Leading to Diffuse Alveolar Hemorrhage.

J Med Toxicol 2016 06;12(2):185-8

Division of Respiratory Medicine and Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada.

Context: Increasing rates of opioid abuse, particularly fentanyl, may lead to more presentations of unusual effects of opioid toxicity. Diffuse alveolar hemorrhage is a rare complication of fentanyl overdose.

Case Details: A 45-year-old male presented in hypoxic respiratory failure secondary to diffuse alveolar hemorrhage requiring intubation. Read More

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http://dx.doi.org/10.1007/s13181-015-0509-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880598PMC
June 2016
10 Reads

Systemic Lead Toxicity.

Orthopedics 2015 Oct;38(10):592, 644-7

A 4-year-old girl with slow mentation had increasing knee tenderness and limping gait. Read More

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http://dx.doi.org/10.3928/01477447-20151002-01DOI Listing
October 2015
4 Reads

Severe neurologic impairment and uncommon magnetic resonance imaging findings after carbon monoxide poisoning.

Am J Emerg Med 2016 Jan 29;34(1):119.e1-2. Epub 2015 May 29.

Department of Anesthesiology and Critical Care Medicine, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, BP 406, 92141 Clamart cedex, France. Electronic address:

Carbon monoxide poisoning is the most common cause of fatal poisoning worldwide and can lead to severe brain damages. We report a delayed encephalopathy after a severe carbon monoxide poisoning with uncommon magnetic resonance imaging findings. Read More

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http://dx.doi.org/10.1016/j.ajem.2015.05.034DOI Listing
January 2016
3 Reads

The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead.

Toxicology 2015 Aug 8;334:12-21. Epub 2015 May 8.

Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wrocław, Poland. Electronic address:

Unlabelled: The aim of this study was to find a relationship between polymorphisms of ALAD rs1805313, rs222808, rs1139488, VDR FokI and HFE C282Y and H63D and basic toxicological parameters (lead and ZnPP blood concentration) in people occupationally exposed to lead. We collected data of 101 workers (age 25-63 years) directly exposed to lead. The toxicological lab tests included blood lead, cadmium and ZnPP concentration measurement and arsenic urine concentration measurement. Read More

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http://dx.doi.org/10.1016/j.tox.2015.05.002DOI Listing
August 2015
56 Reads

Firearms, bullets, and wound ballistics: an imaging primer.

Injury 2015 Jul 30;46(7):1186-96. Epub 2015 Jan 30.

Division of Emergency Radiology, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States.

Based on its intrinsic mass and velocity, a bullet has an upper limit of wounding potential. Actual wound severity is a function of the bullet construction and trajectory, as well as the properties of the tissues traversed. Interpreting physicians must evaluate the bullet trajectory and describe patterns of injury resulting from the effect of energy transfer from the projectile into living tissue. Read More

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http://dx.doi.org/10.1016/j.injury.2015.01.034DOI Listing
July 2015
37 Reads

Trace metal imaging in diagnostic of hepatic metal disease.

Mass Spectrom Rev 2016 10 11;35(6):666-686. Epub 2015 Feb 11.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, D-52074, Aachen, Germany.

The liver is the most central organ and the largest gland of the body that influences and controls a variety of metabolic and catabolic processes. It produces inconceivable many essential proteins, is responsible for the recovery of various food components, degrades toxins, mediates the bile production, and is involved in the excretion of unwanted metabolites. Several of these anabolic or catabolic functions of the liver depend on trace elements. Read More

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http://dx.doi.org/10.1002/mas.21454DOI Listing
October 2016
5 Reads

A new cytotoxicity assay for brevetoxins using fluorescence microscopy.

Mar Drugs 2014 Sep 23;12(9):4868-82. Epub 2014 Sep 23.

UNCW Center for Marine Science, 5600 Marvin K Moss Lane, Wilmington, NC 28409, USA.

Brevetoxins are a family of ladder-framed polyether toxins produced during blooms of the marine dinoflagellate, Karenia brevis. Consumption of shellfish or finfish exposed to brevetoxins can lead to the development of neurotoxic shellfish poisoning. The toxic effects of brevetoxins are believed to be due to the activation of voltage-sensitive sodium channels in cell membranes. Read More

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http://dx.doi.org/10.3390/md12094868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178485PMC
September 2014
7 Reads

Methylene blue treatment delays progression of perfusion-diffusion mismatch to infarct in permanent ischemic stroke.

Brain Res 2014 Nov 8;1588:144-9. Epub 2014 Sep 8.

Research Imaging Institute, Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States. Electronic address:

Stroke is a leading cause of morbidity and mortality in the world. Low-dose methylene blue (MB), which has been used safely to treat methemoglobinemia and cyanide poisoning in humans, has energy enhancing and antioxidant properties. We tested the hypothesis that methylene blue treatment delays progression of at-risk tissue (ca. Read More

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http://ric.uthscsa.edu/duong/2014Nov_MBpermanentMCAO.pdf
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S000689931401194
Publisher Site
http://dx.doi.org/10.1016/j.brainres.2014.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907336PMC
November 2014
16 Reads

Lead-induced impairments in the neural processes related to working memory function.

PLoS One 2014 20;9(8):e105308. Epub 2014 Aug 20.

Department of Medical & Biological Engineering, Kyungpook National University, Dong-In dong, Jung-gu, Daegu, Korea; Department of Radiology, Kyungpook National University College of Medicine, Dong-In dong, Jung-gu, Daegu, Korea; Department of Molecular Medicine, Kyungpook National University College of Medicine, Dong-In dong, Jung-gu, Daegu, Korea.

Background: It is well known that lead exposure induces neurotoxic effects, which can result in a variety of neurocognitive dysfunction. Especially, occupational lead exposures in adults are associated with decreases in cognitive performance including working memory. Despite recent advances in human neuroimaging techniques, the neural correlates of lead-exposed cognitive impairment remain unclear. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105308PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139362PMC
May 2015
14 Reads

Moderating effect of working memory capacity on acute alcohol effects on BOLD response during inhibition and error monitoring in male heavy drinkers.

Psychopharmacology (Berl) 2015 Feb 17;232(4):765-76. Epub 2014 Aug 17.

Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd NE, Albuquerque, NM, 87106, USA,

Rationale: While alcohol intoxication is known to increase disinhibited behavior, the degree to which disinhibition occurs appears to depend on a number of factors including executive functioning ability. However, the neural mechanisms by which individual differences in executive functioning lead to variable degrees of disinhibition remain unclear.

Objectives: The aim of the current study was to examine the neural mechanisms by which individual differences in working memory (WM) capacity moderate alcohol-induced disinhibition. Read More

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http://dx.doi.org/10.1007/s00213-014-3711-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310804PMC
February 2015
20 Reads

Posterior spinal artery aneurysm rupture after 'Ecstasy' abuse.

BMJ Case Rep 2014 Jul 3;2014. Epub 2014 Jul 3.

Department of Neurology and Neurosurgery, University of Miami, Miami, Florida, USA.

Posterior spinal artery (PSA) aneurysms are a rare cause of subarachnoid hemorrhage (SAH). The commonly abused street drug 3,4-methylenedioxymethamphetamine (MDMA) or 'Ecstasy' has been linked to both systemic and neurological complications. A teenager presented with neck stiffness, headaches and nausea after ingesting 'Ecstasy'. Read More

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http://dx.doi.org/10.1136/bcr-2014-011248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091472PMC
July 2014
4 Reads

Lead encephalopathy in adults.

J Neurosci Rural Pract 2014 Apr;5(2):161-3

Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Lead poisoning is a common occupational health hazard in developing countries. We report the varied clinical presentation, diagnostic and management issues in two adult patients with lead encephalopathy. Both patients worked in a battery manufacturing unit. Read More

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http://dx.doi.org/10.4103/0976-3147.131665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064184PMC
April 2014
3 Reads

TRPC1 is involved in Ca²⁺ influx and cytotoxicity following Pb²⁺ exposure in human embryonic kidney cells.

Toxicol Lett 2014 Aug 3;229(1):52-8. Epub 2014 Jun 3.

Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong Province 510515, China. Electronic address:

Lead (Pb(2+)) is a divalent heavy metal ion which causes severe damage to almost all life forms and is therefore considered a notorious toxicant. Exposure to Pb(2+) is associated with poor cognitive development in children at relatively low levels that previously were thought to be safe. The mechanism through which Pb(2+) enters cells, however, is unclear. Read More

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http://dx.doi.org/10.1016/j.toxlet.2014.05.017DOI Listing
August 2014
39 Reads

Management of hepatic encephalopathy.

Curr Treat Options Neurol 2014 Jun;16(6):297

Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA,

Opinion Statement: Hepatic encephalopathy management varies depending on the acuity of liver failure. However, in patients with either acute or chronic liver failure five basic steps in management are critical: stabilization, addressing modifiable precipitating factors, lowering blood ammonia, managing elevated intracranial pressure (ICP) (if present), and managing complications of liver failure that can contribute to encephalopathy, particularly hyponatremia. Because liver failure patients are prone to a variety of other medical problems that can lead to encephalopathy (such as coagulopathy associated intracranial hemorrhage, electrolyte disarray, renal failure, hypotension, hypoglycemia, and infection), a thorough history, physical and neurologic examination is mandated in all encephalopathic liver failure patients. Read More

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http://dx.doi.org/10.1007/s11940-014-0297-2DOI Listing
June 2014
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The impacts of acute carbon monoxide poisoning on the brain: Longitudinal clinical and 99mTc ethyl cysteinate brain SPECT characterization of patients with persistent and delayed neurological sequelae.

Clin Neurol Neurosurg 2014 Apr 15;119:21-7. Epub 2014 Jan 15.

Department of Nuclear Medicine, Cardinal Tien Hospital, Taipei, Taiwan; School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan. Electronic address:

Objective: Acute carbon monoxide (CO) poisoning poses a significant threat to the central nervous system. It can cause brain injury and diverse neurological deficits including persistent neurological sequelae (PNS) and delayed neurological sequelae (DNS). The study aimed to investigate the long-term impacts of acute CO poisoning on brain perfusion and neurological function, and to explore potential differences between PNS and DNS patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467140001
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http://dx.doi.org/10.1016/j.clineuro.2014.01.005DOI Listing
April 2014
36 Reads

Systemic plumbism following remote ballistic injury.

Emerg Radiol 2014 Aug 4;21(4):423-6. Epub 2014 Mar 4.

ER division, Department of Radiology, Henry Ford Hospital, Detroit, MI, USA,

We report an unusual case of systemic lead poisoning, i.e., plumbism, following a remote gunshot injury to the right femur. Read More

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http://dx.doi.org/10.1007/s10140-014-1207-3DOI Listing
August 2014
3 Reads