558,742 results match your criteria Lead Poisoning Imaging
Audiol Neurootol 2018 Dec 11;23(5):259-269. Epub 2018 Dec 11.
BK21 PLUS Program in Embodiment: Health-Society Interaction, Department of Public Health Sciences, Graduate School, Korea University, Seoul, Republic of Korea.
Previous studies have reported that exposure to lead and cadmium can damage the inner ear receptor, which perceives high-frequency sounds. However, few studies have used the pure-tone average (PTA), including high-frequency ranges, for the estimation of hearing loss caused by lead and cadmium exposure. We estimated hearing loss using the PTA test, in low-frequency, speech frequency, and high-frequency ranges and compared the differences in the results using 3 PTA calculation methods. Read More
Cardiorenal Med 2018 Dec 11;9(2):69-82. Epub 2018 Dec 11.
Harold Simmons Center of Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California,
Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels. Read More
Psychiatry Res 2018 Dec 6;271:446-453. Epub 2018 Dec 6.
Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, 20127 Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
The relationship between neurocognition and functioning among patients with schizophrenia is well documented. However, integrating neuropsychological, clinical and psychopathological data to better investigate functional outcome still constitutes a challenge. Artificial neural network-based modeling might help to better capture clinical heterogeneity by analyzing the non-linear relationships among multiple variables. Read More
Environ Int 2018 Dec 8;123:231-239. Epub 2018 Dec 8.
Department of Innovation, Evidence and Research, World Health Organization, Av. Appia 20 CH-1211, Geneva 27, Switzerland. Electronic address:
Background: Approximately one quarter of all deaths globally are attributed to living or working in an unhealthy environment, with household and ambient air pollution, along with exposures to ultraviolet radiation and chemicals amongst the leading causes. At present there are no international standards for assessing the risks of these environmental hazards. The use of heterogeneous methods to identify health risks from environmental hazards may reduce the level of confidence the public has in the conclusions that are made. Read More
J Plant Physiol 2018 Nov 20;232:94-99. Epub 2018 Nov 20.
Institute of Basic Biological Problems of Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
The carrier of carbonic anhydrase (CA) activity was detected in gel among low molecular mass proteins from pea, spinach and Arabidopsis, after nondenaturing electrophoresis in PAAG of the dodecyl-β-d-maltoside treated PSII membranes (the fragments of thylakoid membrane containing PSII complexes). The elimination of Mn-stabilizing protein PsbO by treatment of PSII membranes with salts, did not lead to a decrease in CA activity observed in the gel although it reduced the amount of this protein down to 25% compared to the original sample. The isolated protein PsbO did not demonstrated CA activity. Read More
Sci Total Environ 2018 Dec 5;657:146-153. Epub 2018 Dec 5.
Center for Water Cycle, Marine Environment and Disaster Management, Kumamoto University, Japan.
There are growing concerns about nitrate contamination in Kumamoto City, where >700,000 people completely depend on groundwater as a source of drinking water. We found that some groundwater samples showed considerably different nitrate concentrations although their sampling locations were close to one another, and we speculated that this phenomenon was due to the differences in subsurface geological properties. In order to verify this hypothesis, we carried out temporally intensive long-term monitoring of the groundwater levels and water qualities at three of the closely related sampling wells, and the results revealed that the changes in water level and water quality were different at each well. Read More
Comput Biol Med 2018 Nov 22;104:250-266. Epub 2018 Nov 22.
Department of Systems Science and Engineering, Zhejiang University, China. Electronic address:
This paper analyzes how ultrasounds could have unintentionally led to the AP news recordings of metallic sounds heard by diplomats in Cuba. Beginning with screen shots of the acoustic spectral plots from the AP news, we reverse engineered ultrasonic signals that could lead to those outcomes as a result of intermodulation distortion with non-linearity in the acoustic transmission medium. We created a proof of concept ultrasonic device that amplitude modulates a signal over an inaudible ultrasonic carrier. Read More
Spine J 2018 Dec 8. Epub 2018 Dec 8.
Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. Electronic address:
Background Context: A spinal epidural abscess (SEA) is a serious condition that may be managed with antibiotics alone or with decompressive surgery combined with antibiotics.
Purpose: The objectives of this study were to assess the clinical outcomes of SEA after surgical management and to identify the patient-level factors that are associated with outcomes following surgical decompression and removal of SEA.
Study Design/setting: Retrospective chart review analysis. Read More
Neurosci Biobehav Rev 2018 Dec 8. Epub 2018 Dec 8.
Department of Pediatrics, Dalhousie University and the IWK Health Centre, Canada.
Regression in children with epilepsy may involve loss of cognitive abilities, failure to progress or a slowing of developmental trajectory. A few seizures do not lead to regression. Large numbers of seizures may be associated with regression but the cause is an important cofounder. Read More
Am J Physiol Regul Integr Comp Physiol 2018 Dec 19;315(6):R1254-R1260. Epub 2018 Sep 19.
Foods and Nutrition, University of Georgia , Athens, Georgia.
There is accumulating evidence that the gut microbiota and its composition dynamics play a crucial role in regulating the host physiological functions and behavior. Diet composition is the primary modulator of bacterial richness and abundance in the gastrointestinal (GI) tract. Macronutrient (fat, sugar, and protein) and fiber contents are especially important in determining microbiota composition and its effect on health outcomes and behavior. Read More
Genesis 2018 Dec 10:e23269. Epub 2018 Dec 10.
Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Investigation of Drosophila oogenesis provides the opportunity to understand conservative genetic mechanisms underlying fertile female gamete development. In this work, we showed that the Drosophila DNA-binding protein GAGA factor (GAF) had a multifunctional role in oogenesis and it is involved in the regulation of this process genetic program. We studied the influence on Drosophila oogenesis of a number of mutations in the 5' region of the Trl gene that encodes GAF. Read More
Genet Epidemiol 2018 Dec 9. Epub 2018 Dec 9.
Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland.
We develop linear mixed models (LMMs) and functional linear mixed models (FLMMs) for gene-based tests of association between a quantitative trait and genetic variants on pedigrees. The effects of a major gene are modeled as a fixed effect, the contributions of polygenes are modeled as a random effect, and the correlations of pedigree members are modeled via inbreeding/kinship coefficients. -statistics and χ likelihood ratio test (LRT) statistics based on the LMMs and FLMMs are constructed to test for association. Read More
J Dtsch Dermatol Ges 2018 Dec;16(12):1459-1476
While epidemic typhus caused by Rickettsia prowazekii posed a significant threat in Europe before and throughout World War II due to its high mortality, the condition fortunately no longer plays a significant role. Nevertheless, rickettsioses, such as African tick bite fever, have been increasingly diagnosed in travelers returning from sub-Saharan Africa. Caused by Rickettsia africae, African tick bite fever presents with characteristic cutaneous findings such as eschar (tache noir) and a rash. Read More
Stem Cells 2018 Dec 10. Epub 2018 Dec 10.
Department of Orthopaedic Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
The "super-healing" Murphy Roths Large (MRL/MpJ) mouse possesses a superior regenerative capacity for repair of many tissues, which makes it an excellent animal model for studying molecular and cellular mechanisms during tissue regeneration. Since the role of muscle progenitor cells (MPCs) in muscle healing capacity of MRL/MpJ mice has not been previously studied, we investigated the muscle regenerative capacity of MRL/MpJ mice following muscle injury, and the results were compared to results from C57BL/6 J (B6) age-matched control mice. Our results show that muscle healing upon cardiotoxin injury was accelerated in MRL/MpJ mice and characterized by reduced necrotic muscle area, reduced macrophage infiltration, and more regenerated myofibers (eMyHC+/centronucleated fibers) at 3, 5, and 12 days post-injury, when compared to B6 age-matched control mice. Read More
Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.
Department of Anthropology, The Ohio State University, 4034 Smith Laboratory, 174 West 18th Ave., Columbus, OH 43210, USA.
Dental replicas are frequently utilized in paleoanthropological studies of perikymata and enamel hypoplasia. However, fossil teeth are often fragile and worn, causing two problems: (1) the risk of damage by removing enamel fragments when impression-making material is separated from the fossil tooth surface, and (2) the need to reconstruct worn portions of the crown to assess perikymata number, distribution, and hypoplasia timing. This study presents the advantages of μCT data of canines and lateral incisors for (1) detecting cracks along the enamel-dentine junction (EDJ) which could cause damage when casting, and (2) reliably and non-destructively reconstructing worn or broken cusps. Read More
BJU Int 2018 Dec 11. Epub 2018 Dec 11.
Department of Urology, Antwerp University Hospital, Edegem, Belgium.
Objectives: To assess clinical follow-up data over 24 months using the standardized tined lead implantation technique, comparing the use of the curved vs straight stylet.
Patients And Methods: Single tertiary center, prospective study (August 2013 - June 2015) involving 40 patients with overactive bladder and 15 with non-obstructive urinary retention refractory to first-line treatment.
Primary Outcome: successful tined lead procedure; intention to treat analysis at 12 and 24 months. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
The Department of Oncology, Hebei Chest Hospital, Shijiazhuang, Hebei, China.
Renal cell carcinoma (RCC) is a common kidney tumor in adults. The role of miR-486-5p in RCC is unknown. The aim of our study was to identify new targets regulated by miR-486-5p in RCC, to obtain a deeper insight into the network and to better understand the role of these microRNAs and their targets in carcinogenesis of RCC. Read More
Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.
Universität Gießen, Heinrich-Buff-Ring 58, 35392, Gießen, GERMANY.
LiNiO₂ (LNO) has been introduced as cathode active material (CAM) for Li-ion batteries in 1990. After years of intensive research, it emerged that several instability issues plague the material, so that it was abandoned in favor of isostructural metal-substituted compounds called NCA (for lithium nickel cobalt aluminum oxide) and NCM (lithium nickel cobalt manganese oxide). These sacrifice a certain amount of specific energy in exchange for stability, durability and safety. Read More
Pediatr Transplant 2018 Dec 9:e13329. Epub 2018 Dec 9.
Department of Pediatrics and Transplantation Center, University Hospital Motol, 2nd Medical Faculty Prague, Charles University Prague, Prague, Czech Republic.
Objectives: Strict BP control can retard progression of CKD in children. This prospective 3-year randomized controlled trial is aimed to investigate whether strict BP control can retard progression of chronic allograft dysfunction.
Methods: Twenty-three pediatric patients were randomly selected to the standard BP group (STAND, target 24-hour MAP 50-95th percentile, n = 11) or the intensified BP group (INTENS, target 24-hour MAP <50th percentile, n = 12). Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Department of Critical Care Medicine, Shanghai Jiaotong University affiliated to The Sixth People's Hospital, Shanghai, China.
The balance between Ang II/AT1R and Ang-(1-7)/Mas plays a pivotal role in the development of lipopolysaccharides (LPS)-induced acute respiratory distress syndrome. However, the mechanisms underlying the balancing process still remain unclear. Here we investigated the roles of nuclear factor (NF)-κB and p53 in regulating AT1R and Mas expression. Read More
J Adv Nurs 2018 Dec 10. Epub 2018 Dec 10.
School of Nursing and Midwifery & Menzies Health Institute Queensland, Griffith University, Australia.
Aim: To assess the effectiveness of psychosocial interventions on pain in older adults living with dementia.
Design: A systematic review with meta-analysis of randomised controlled trials.
Data Sources: Scopus, ProQuest, EBSCO (CINAHL and MEDLINE), PubMed, OVID (PsycINFO), Web of Science and Cochrane Library were searched from their inception up to 2 May 2018. Read More
Drug Dev Res 2018 Dec 10. Epub 2018 Dec 10.
Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan, South Korea.
1α,25-Dihydroxyvitamin D (also called 1,25(OH) D or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CYP3A) expression was altered by 1,25(OH) D -mediated VDR activation. However, to clarify whether the change in CYP3A subfamily expression by VDR activation can affect metabolic function, further evidence is needed to prove the effect of 1,25(OH) D treatment on CYP3A-mediated drug metabolism and pharmacokinetics. Read More
J Cell Physiol 2018 Dec 8. Epub 2018 Dec 8.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Irradiation (IR) can be used to treat cancer by inducing complex and irreparable DNA damage in the cancer cells, which may lead to their apoptotic death. However, little is known about the molecular mechanism of this DNA damage. Here, the non-small-cell lung cancer cell line A549 was treated with either X-ray or carbon ion combined with bleomycin (BLM). Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Pyroptosis, a type of programmed cell death mediated by gasdermin, is characterized by the swelling and rupture of cells, release of cellular contents and a strong inflammatory response, which is critical for controlling microbial infection. Pattern recognition receptors recognize the intracellular and extracellular pathogenic microbial components and stimulate the organism's inflammatory response by activating the pyroptosis signaling pathway and releasing interleukin-1β (IL-1β), IL-18, and other inflammatory factors to promote pathogen clearance and prevent infection. In the process of continuous evolution, pathogens have developed multiple strategies to modulate the occurrence of pyroptosis and thus enhance their ability to induce disease; that is, the competition between host cells and pathogens controls the occurrence of pyroptosis. Read More
J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Objective: To study the mechanism of collapsin response mediator protein-2 (CRMP-2) phosphorylation changes and cyclin-dependent kinase 5 (CDK5) expression after optic nerve injury.
Methods: Optic nerve injury rat models were constructed, the messenger RNA (mRNA) level of CRMP-2 in optic nerve tissues was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) after building models 0, 3, 7, and 14 days. The protein expression of CRMP-2, phospho-CRMP-2 (p-CRMP-2), and CDK5 were also determined by western blot analysis. Read More
J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.
School of Engineering and Technology, Central Michigan University, Mount Pleasant, Michigan, 48859.
Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. Read More
Risk Anal 2018 Dec 10. Epub 2018 Dec 10.
The Institute for Resources, Environment and Sustainability (IRES), University of British Columbia, Vancouver, British Columbia, Canada.
It is well documented that more research can lead to hardened positions, particularly when dealing with complex, controversial, and value-laden issues. This study is an attempt to unveil underlying values in a contemporary debate, where both sides use scientific evidence to support their argument. We analyze the problem framing, vocabulary, interpretation of evidence, and policy recommendations, with particular attention to the framing of nature and technology. Read More
Echocardiography 2018 Dec 9. Epub 2018 Dec 9.
Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.
Residual fibrous structures, referred as "ghosts", are occasionally encountered following lead extraction. Though typically detected in patients with cardiac device infections, their prognostic and therapeutic implications remain speculative. We describe a 62-year-old gentleman with history of sick sinus syndrome who presented atrial fibrillation with rapid ventricular response. Read More
Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.
The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada of the Faculty of Medicine (IMRIC), The Hebrew University Hadassah Medical School, 91120, Jerusalem, Israel.
Natural Killer (NK) cells are innate lymphocytes that efficiently eliminate cancerous and infected cells. NKp46 is an important NK activating receptor shown to participate in recognition and activation of NK cells against pathogens, tumor cells, virally infected cells, and self-cells in autoimmune conditions, including type I and II diabetes. However, some of the NKp46 ligands are unknown and therefore investigating human NKp46 activity and its critical role in NK cell biology is problematic. Read More
Biotechnol Prog 2018 Dec 8:e2764. Epub 2018 Dec 8.
Department of Chemical Engineering, 1280 Main Street West, McMaster University, Hamilton, Ontario, Canada, L8S 4L7.
Rolling circle amplification (RCA), polymerase chain reaction (PCR), and loop-mediated isothermal amplification (LAMP), are powerful tools that can be used for gene manipulation, pathogen detection, and infectious disease diagnostics. However, these techniques require trained personnel, as the pipetting steps involved can lead to contamination and, consequently, erroneous results. Furthermore, many of the reagents used in molecular biology are thermally labile and must be kept within a cold-chain. Read More
Cochrane Database Syst Rev 2018 Nov 15;11:CD009901. Epub 2018 Nov 15.
Wiesbaden Business School, RheinMain University of Applied Science, Bleichstr. 44, Wiesbaden, Germany, 65183.
Background: Percutaneous dilatational tracheostomy (PDT) is one of the most common bedside surgical procedures performed in critically ill adults, on intensive care units (ICUs), who require long-term ventilation. PDT is associated with relevant life-threatening complications: Cuff rupture or accidental extubation may lead to hypoxia, aspiration or loss of airway. Puncture of the oesophagus, or creating a false passage during dilatation or replacement of the tracheostomy tube, can lead to pneumothorax or emphysema. Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Diabetic nephropathy is the leading cause of renal failure worldwide. This debilitating disorder has several underlying pathophysiologic mechanisms, and therefore a variety of pharmacologic agents have been developed to prevent or treat diabetic nephropathy; however, synthetic drugs may possess unfavorable side effects. In response to this, the global use of herbal-based pharmacologic agents is increasing among diabetic patients. Read More
Am J Med Genet B Neuropsychiatr Genet 2018 Dec 7. Epub 2018 Dec 7.
University of Alabama at Birmingham, Birmingham, Alabama.
Mutations in the X-linked gene MECP2 are associated with a severe neurodevelopmental disorder, Rett syndrome (RTT), primarily in girls. It had been suspected that mutations in Methyl-CpG-binding protein 2 (MECP2) led to embryonic lethality in males, however such males have been reported. To enhance understanding of the phenotypic spectrum present in these individuals, we identified 30 males with MECP2 mutations in the RTT Natural History Study databases. Read More
Plant Cell Environ 2018 Dec 7. Epub 2018 Dec 7.
Hainan Key Laboratory for Sustainable Utilisation of Tropical Bioresource, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570288, China.
Salt stress is a major environmental threat to meeting the food demands of an increasing global population. The identification and exploitation of salt adaption mechanisms in plants is therefore vital for crop breeding. We here define the rice mutant (sstm1) whose salt-sensitivity was unambiguously assigned to a single T-DNA insertion through segregational analysis following backcrossing to the wild type line. Read More
Emerg Med Australas 2018 Dec 11. Epub 2018 Dec 11.
Sunshine Coast Hospital and Health Service, Sunshine Coast Region, Queensland, Australia.
Objective: Agricultural industries are among the most dangerous in Australia posing significant public health risks. This study analyses the nature and management of agriculture-related injuries presenting to EDs in selected hospitals in Southern Queensland.
Methods: Data on agricultural injury presentations over a 6 month period was collected at four rural hospitals by a dedicated onsite hospital data coordinator. Read More
Am J Hum Biol 2018 Dec 10:e23208. Epub 2018 Dec 10.
Department of Psychology, The Ohio State University, Columbus, Ohio.
Objectives: The present study sought to expand upon prior investigations examining patterns of vagally mediated heart rate variability (vmHRV) and perceived exertion as a function of body mass index (BMI) in response to and recovery from exercise.
Methods: Participants underwent a resting (baseline) period, followed by a graded exercise protocol on an ergometer with ascending difficulty stages, and finally another resting (recovery) period. Individuals were stratified into three BMI groups: low, moderate, and high. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Read More
J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.
Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.
Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).
Design: Consensus meeting.
Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More
Angew Chem Int Ed Engl 2018 Dec 7. Epub 2018 Dec 7.
Ludwig-Maximilians-Universität München, Department Chemie Lehrstuhl f. Anorganische Festkörperchemie, Butenandtstr. 5-13, 81377, München, GERMANY.
Due to the weak oxidative force of N2, nitrides are only typically formed with the less electronegative metals. Meeting this challenge, we here present Pb2Si5N8, the first nitridosilicate containing highly electron-affine cations of a metal from the right side of the Zintl border. By using advanced synchrotron X-ray diffraction, the crystal structure was determined from a tiny single crystal of 1×3×3 μm3 in size, revealing a significantly different bonding situation compared to all other nitridosilicates known so far. Read More
Adv Mater 2018 Dec 9:e1800690. Epub 2018 Dec 9.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Controllable fabrication of graphene is necessary for its practical application. Chemical vapor deposition (CVD) approaches based on solid metal substrates with morphology-rich surfaces, such as copper (Cu) and nickel (Ni), suffer from the drawbacks of inhomogeneous nucleation and uncontrollable carbon precipitation. Liquid substrates offer a quasiatomically smooth surface, which enables the growth of uniform graphene layers. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
Department of Respiration, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Pulmonary fibrosis (PF) is a fibroproliferative disease that can eventually lead to fatal lung failure. It is characterized by abnormal proliferation of fibroblasts, dysregulated fibroblast differentiation to myofibroblast, and disorganized collagen and extracellular matrix production, deposition and degradation. There is still a lack of effective treatment strategies for PF. Read More
Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.
Universita degli Studi di Pavia, Chimica, Via Taramelli 12, 27100, Pavia, ITALY.
Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of substantia nigra pars compacta in Parkinson's disease represents the best-studied link between DA neurotransmission and neuropathology. Catecholamines are reactive molecules that are handled through complex control and transport systems. Read More
Chem Biodivers 2018 Dec 9. Epub 2018 Dec 9.
: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China, CHINA.
Influenza A virus (IAV), a highly pathogenic virus to human beings, is most susceptible to mutation and thus causes rapid, severe global pandemics resulting in millions of fatalities worldwide. Since resistance to the existing anti-inﬂuenza drugs is developing, innovative inhibitors with a different mode of action are urgently needed. The lead compound 6092B-E5 has proven to be an effective antiviral reagent in our previous work. Read More
Physiol Rep 2018 Dec;6(23):e13940
Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Age-related alterations in whole body composition, particularly, reduced fat free mass (FFM) and increased fat mass (FM), lead to a progressive decline in resting energy expenditure (REE). Similarly, regional body composition and fat distribution changes with age might also contribute to an overall lower REE. This study investigated the influence of age on REE, regional body composition and fat distribution, including subcutaneous fat (SF) and visceral fat (VF), in a Chinese Han population as well as their contributions to age-related changes in REE. Read More
J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Cardiac complications including arrhythmia and especially atrial fibrillation (AF) are common causes of death in β-thalassemia patients. The main factor in the etiopathogenesis of these complications is iron overload, which results in increased oxidative stress. Although there is a known association between cardiac complications and iron overload in β-thalassemia patients, there is no comprehensive review on AF and excessive iron with a focus on oxidative stress in these patients. Read More
Macromol Rapid Commun 2018 Dec 7:e1800713. Epub 2018 Dec 7.
Max Planck Institute for Polymer Research, Ackermannweg, 10, Germany.
A reversible polymer photoacid with a thermal on/off switch at physiological temperature able to trigger a large pH modulation of its environment is prepared. Light is used to control the acidity of the solution. Additionally, the temperature could be used to modulate the photoacid efficiency, practically turning on and off the ability of the polymer to produce protons. Read More
Nurs Forum 2018 Dec 9. Epub 2018 Dec 9.
Center of Innovation in Long-Term Services and Supports, Providence VA Medical Center, Providence, RI.
Natural disasters impact people of every age in the communities where they occur, with older adults being a vulnerable subset of the population. Most disaster shelter volunteer nurses are experienced in addressing common health needs of older adult clients such as diabetes, hypertension, and pulmonary disease. These nurses also have the requisite training to respond to more acute medical events, including the symptoms of a heart attack or stroke. Read More
Biom J 2018 Dec 10. Epub 2018 Dec 10.
Department of Mathematics and Statistics, Memorial University, St. John's, NL, Canada.
Due to increasing discoveries of biomarkers and observed diversity among patients, there is growing interest in personalized medicine for the purpose of increasing the well-being of patients (ethics) and extending human life. In fact, these biomarkers and observed heterogeneity among patients are useful covariates that can be used to achieve the ethical goals of clinical trials and improving the efficiency of statistical inference. Covariate-adjusted response-adaptive (CARA) design was developed to use information in such covariates in randomization to maximize the well-being of participating patients as well as increase the efficiency of statistical inference at the end of a clinical trial. Read More
Br J Clin Pharmacol 2018 Dec 8. Epub 2018 Dec 8.
Pfizer Oncology, Collegeville, PA, USA.
Aim: To characterize the effect of inotuzumab ozogamicin on QT interval in patients with B-cell malignancies.
Methods: Data were pooled from three clinical studies including 250 patients (N=2743) who received inotuzumab ozogamicin monotherapy. Patients with relapsed/refractory acute lymphoblastic leukaemia (NCT01564784 and NCT01363297) received 1. Read More