11,930 results match your criteria Lead Nephropathy


Calcium Dobesilate and Micro-vascular diseases.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.023DOI Listing
February 2019

Increasing of the interferon-γ gene expression during polyomavirus BK infection in kidney transplant patients.

Microb Pathog 2019 Feb 12. Epub 2019 Feb 12.

Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Polyomavirus BK infection is a common complication and a major cause of morbidity after kidney transplantation. Surveillance of kidney transplant recipients was threatened by reactivation of polyomavirus BK infection can lead to polyomavirus BK-associated nephropathy (PVN). Antiviral immunoregulatory markers like Gamma interferon (IFN-γ) might also affect the polyomavirus BK pathogenesis for its role in antiviral host defense, graft rejection, and regulative of the adaptive immune responses. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.015DOI Listing
February 2019

miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.

The expression changes of CD2-associated protein (CD2AP) can lead to kidney diseases with proteinuria, including nephrotic syndrome (NS). A recent study reported that miRNAs may be important transcriptional regulators. In this study, we found increased expression of miR-939-5p and decreased expression of CD2AP in the peripheral blood of patients with NS. Read More

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http://dx.doi.org/10.1002/jcb.28413DOI Listing
February 2019
3.263 Impact Factor

Evaluating Community-Based Translational Interventions Using Historical Controls: Propensity Score vs. Disease Risk Score Approach.

Prev Sci 2019 Feb 12. Epub 2019 Feb 12.

Centers for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Many community-based translations of evidence-based interventions are designed as one-arm studies due to ethical and other considerations. Evaluating the impacts of such programs is challenging. Here, we examine the effectiveness of the lifestyle intervention implemented by the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) demonstration project, a translational lifestyle intervention among American Indian and Alaska Native communities. Read More

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http://dx.doi.org/10.1007/s11121-019-0980-3DOI Listing
February 2019

Early decrease in the podocalyxin to synaptopodin ratio in urinary Fabry podocytes.

Clin Kidney J 2019 Feb 20;12(1):53-60. Epub 2018 Jul 20.

IFIBIO Houssay, CONICET, Physiopathology, Pharmacy and Biochemistry Faculty, Universidad de Buenos Aires, Buenos Aires, Argentina.

Background: In Fabry nephropathy, podocyturia is an early event that may lead to glomerulosclerosis and chronic kidney disease. The glycocalyx is a potential podocyte damaged compartment in glomerulopathies. We investigated glycocalyx podocalyxin in urinary detached podocytes compared with cytoplasmic synaptopodin. Read More

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http://dx.doi.org/10.1093/ckj/sfy053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366138PMC
February 2019

Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways.

J Cell Physiol 2019 Feb 11. Epub 2019 Feb 11.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. Read More

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http://dx.doi.org/10.1002/jcp.28315DOI Listing
February 2019
1 Read

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome.

Nephron 2019 Feb 6:1-9. Epub 2019 Feb 6.

Department of Pediatric Nephrology, Saglik Bilimleri University, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Background: There is a growing body of evidence showing that there is an association between oxidative damage and kidney injury in patients with nephrotic syndrome (NS). Dynamic thiol/disulphide homeostasis (DTDH) is an important antioxidant system. The aim of this study was to determine if DTDH could be used as a biomarker of antioxidant status in pediatric NS patients using a novel automated method. Read More

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http://dx.doi.org/10.1159/000496619DOI Listing
February 2019
2 Reads

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

Nat Genet 2019 Feb 4. Epub 2019 Feb 4.

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

To understand the genetics of type 2 diabetes in people of Japanese ancestry, we conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases and 155,150 controls of Japanese ancestry). We identified 88 type 2 diabetes-associated loci (P < 5.0 × 10) with 115 independent signals (P < 5. Read More

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http://www.nature.com/articles/s41588-018-0332-4
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http://dx.doi.org/10.1038/s41588-018-0332-4DOI Listing
February 2019
2 Reads

Assessing and Reporting Household Chemicals as a Novel Tool to Mitigate Pesticide Residues in Spinach (Spinacia oleracea).

Sci Rep 2019 Feb 4;9(1):1125. Epub 2019 Feb 4.

Department of Environmental Science, International Islamic University, Islamabad, Pakistan.

Non-selective use of pesticide to increase productivity leaves residues on crops. These pesticides after consumption have a detrimental effect on human health and their intake can lead to various diseases such as kidney damage, neurological disorders, cardiovascular diseases, circulatory and reproductive problems. The recent study was designed to assess the effects of household processing treatments such as acidic solutions (acidic acid and citric acid), alkaline solutions (sodium chloride and sodium carbonate) and biological solutions (radish, ginger, garlic, and lemon extracts) were evaluated for their efficiency for removal of pesticides in spinach by gas chromatography with electron capture detector (GC-ECD). Read More

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http://dx.doi.org/10.1038/s41598-018-37936-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362137PMC
February 2019
2 Reads

Screening of subtype specific activators and inhibitors for diacylglycerol kinase.

J Biochem 2019 Feb 4. Epub 2019 Feb 4.

Department of Applied Chemistry in Bioscience, Graduate School of Agricultural Science, Faculty of Agriculture, Kobe University, Rokkodai-cho 1-1, Nada-ku, Kobe, Japan.

Diacylglycerol kinase (DGK) is a lipid kinase that converts diacylglycerol (DG) into phosphatidic acid (PA). DG and PA function as lipid messengers contributing to various signaling pathways. Thus, DGK plays a pivotal role in the signaling pathways by maintaining DG and PA levels. Read More

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https://academic.oup.com/jb/advance-article/doi/10.1093/jb/m
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http://dx.doi.org/10.1093/jb/mvz008DOI Listing
February 2019
3 Reads

Effect of Polyoma viremia on three-year allograft kidney function.

Transpl Infect Dis 2019 Feb 3:e13056. Epub 2019 Feb 3.

Renal Transplantation Service - Division of Urology.

Background: Polyoma viremia is associated with damage to renal tubular and urothelial cells. This may imply that a certain level of viremia, even cleared thereafter, could be associated with long-term renal dysfunction.

Methods: We, retrospectively, analyzed 390 first renal transplants adult recipients (≥18y) who were monitored for BK viremia in the first 12 months and evaluated estimated GFR (MDRD-4 equation) at one month and at the last follow-up (959±392 days). Read More

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http://dx.doi.org/10.1111/tid.13056DOI Listing
February 2019
1 Read

End-Stage Kidney Diseases in Immigrant Groups: A Nationwide Cohort Study in Sweden.

Am J Nephrol 2019 Feb 1;49(3):186-192. Epub 2019 Feb 1.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Background: Our aim was to study the association between the country of birth and incident end-stage kidney disease (ESKD) in several immigrant groups in Sweden, using individuals born in Sweden or with Swedish-born parents as referents.

Methods: A cohort study of first- and second-generation immigrants residing in Sweden between January 1, 1998 and December 31, 2012 was performed. Outcomes were defined as having at least one registered diagnosis of ESKD in the National Patient Register. Read More

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https://www.karger.com/Article/FullText/497063
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http://dx.doi.org/10.1159/000497063DOI Listing
February 2019
4 Reads

Prognosis of BK polyomavirus nephropathy: 10-year analysis of 133 renal transplant recipients at a single center.

Chin Med J (Engl) 2019 Feb;132(4):388-394

Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.

Background: BK virus-associated nephropathy (BKVN) is an important cause of chronic allograft dysfunction. The objective of our study was to evaluate the prognosis of BKVN.

Methods: We retrospectively reviewed the data of 133 renal transplant recipients with BKVN treated at the First Affiliated Hospital of Sun Yat-Sen University between July 2007 and July 2017. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000085DOI Listing
February 2019
1 Read
1.016 Impact Factor

Progress of small ubiquitin-related modifiers in kidney diseases.

Chin Med J (Engl) 2019 Feb;132(4):466-473

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China.

Objective: Small ubiquitin-related modifiers (SUMOs) are a group of post-translational modification proteins extensively expressed in eukaryotes. Abnormal SUMOylation can lead to the development of various diseases. This article summarizes the progress on research of the role of SUMOs in various types of kidney diseases to further increase the understanding of the regulatory functions of SUMOylation in the pathogenesis of kidney diseases. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000094DOI Listing
February 2019
1 Read

[Advances in research on gene and cell therapy for type IV collagen related hereditary kidney diseases].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Feb;36(2):179-182

Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Type IV collagen is a component of the extracellular matrix in the basement membrane. Abnormal secretion or assembly of type IV collagen may lead to kidney lesions resulting in numerous nephropathy symptoms, e.g. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2019.02.022DOI Listing
February 2019
1 Read

Association between hepatitis B virus infection and chronic kidney disease: A cross-sectional study from 3 million population aged 20 to 49 years in rural China.

Medicine (Baltimore) 2019 Feb;98(5):e14262

Beijing Key Laboratory of Urinary Cellular Molecular Diagnostics.

Hepatitis B virus (HBV) infection can lead to different types of chronic kidney diseases (CKD) in clinical practice. However, HBV infection has been observed to have no significant association with CKD indicators in some epidemiological surveys. This research aims to estimate CKD prevalence in HBV infection population and clarify the relationship between HBV infection status and CKD. Read More

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http://dx.doi.org/10.1097/MD.0000000000014262DOI Listing
February 2019
1 Read
5.723 Impact Factor

Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract Alleviates β-Glycerophosphate-Induced Vascular Smooth Muscle Cell Calcification By Inhibiting Wnt/β-Catenin Pathway.

Blood Purif 2019 Jan 30:1-7. Epub 2019 Jan 30.

Department of Nephrology, The First Hospital of China Medical University, Shenyang,

Background: Abnormal mineral metabolism in patients with chronic kidney disease (CKD) may lead to vascular calcification, which is markedly associated with adverse events, including ischemic cardiac diseases and all-cause cardiovascular mortality. Thus, preventing and treating vascular calcification play an important role in improving the prognosis of CKD patients.

Objectives: To investigate the potential functions of sclerostin and low-density lipoprotein receptor-related protein 4 (Lrp4) in alleviating the β-glycerophosphate (β-GP)-induced vascular smooth muscle cell (VSMC) calcification, and the protective effect of Ginkgo biloba extract (GBE). Read More

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http://dx.doi.org/10.1159/000496219DOI Listing
January 2019
1 Read

Amplified Association Between Blood Pressure and Albuminuria in Overweight Patients with Biopsy-Proven Hypertensive Nephrosclerosis.

Am J Hypertens 2019 Jan 26. Epub 2019 Jan 26.

Department of Nephrology and Laboratory Medicine, Kanazawa University, Takara-machi, Kanazawa, Ishikawa, Japan.

Background: An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis.

Methods: A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. Read More

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http://dx.doi.org/10.1093/ajh/hpz010DOI Listing
January 2019
2 Reads

Recommendations on the Diagnosis and Initial Management of Acute Variceal Bleeding and Hepatorenal Syndrome in Patients with Cirrhosis.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.

Cirrhosis is a serious and life-threatening condition which imposes a significant socioeconomic burden on affected individuals and healthcare systems. Cirrhosis can result in portal hypertension, which may lead to major complications, including acute variceal bleeding and hepatorenal syndrome. Without prompt treatment, these complications may be life-threatening. Read More

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http://dx.doi.org/10.1007/s10620-018-5448-yDOI Listing
January 2019
1 Read

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD).

Clin Sci (Lond) 2019 Jan 25;133(2):287-313. Epub 2019 Jan 25.

Pathophysiology of Diabetic Complications Laboratory, Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia

The incidence of chronic kidney diseases (CKDs) is expected to rise, fuelled by the ever increasing epidemic of Type 2 diabetes. Despite extensive research in this area, there are currently no effective treatments available to sufficiently halt the progression of CKD towards renal failure. This is largely due to ongoing secondary pathological processes generally elicited by the onset of disease. Read More

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http://dx.doi.org/10.1042/CS20180438DOI Listing
January 2019
3 Reads

Microsurgical approach for hemodialysis access: A pilot study of Brescia-Cimino fistulas constructed under microscopic guidance.

Medicine (Baltimore) 2019 Jan;98(4):e14202

Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine.

The distal forearm is the preferred site for hemodialysis access. However, forearm vessels have small diameter, which may lead to complications of arteriovenous fistulas constructed at this site. Indeed, the mean patency rate of such fistulas has been reported at 65. Read More

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http://dx.doi.org/10.1097/MD.0000000000014202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358373PMC
January 2019
2 Reads

Unmasking of oestrogen-dependent changes in left ventricular structure and function in aged female rats: a potential model for pre-heart failure with preserved ejection fraction.

J Physiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

Key Points: Heart failure with preserved ejection fraction (HFpEF) is seen more frequently in older women; risk factors include age, hypertension and excess weight. No female animal models of early stage remodelling (pre-HFpEF) have examined the effects that the convergence of such factors have on cardiac structure and function. In this study, we demonstrate that ageing can lead to the development of mild chamber remodelling, diffuse fibrosis and loss of diastolic function. Read More

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http://dx.doi.org/10.1113/JP277479DOI Listing
January 2019
1 Read

Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management.

Diabetol Metab Syndr 2019 23;11. Epub 2019 Jan 23.

Fatima College of Health Sciences, PO Box 57788, Abu Dhabi, UAE.

Background: Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occur in a series of stages and is linked to glycemic and blood pressure control. However, despite aggressive blood sugar control the prevalence of chronic kidney disease (CKD) in diabetic patients has not witnessed any decrease in the last two decades; which has lead to identification of additional factors in its progression. Read More

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https://dmsjournal.biomedcentral.com/articles/10.1186/s13098
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http://dx.doi.org/10.1186/s13098-019-0403-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343294PMC
January 2019
8 Reads

The Demographic Diversity of Food Intake and Prevalence of Kidney Stone Diseases in the Indian Continent.

Foods 2019 Jan 21;8(1). Epub 2019 Jan 21.

Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, India.

Food intake plays a pivotal role in human growth, constituting 45% of the global economy and wellbeing in general. The consumption of a balanced diet is essential for overall good health, and a lack of equilibrium can lead to malnutrition, prenatal death, obesity, osteoporosis and bone fractures, coronary heart diseases (CHD), idiopathic hypercalciuria, diabetes, and many other conditions. CHD, osteoporosis, malnutrition, and obesity are extensively discussed in the literature, although there are fragmented findings in the realm of kidney stone diseases (KSD) and their correlation with food intake. Read More

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http://www.mdpi.com/2304-8158/8/1/37
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http://dx.doi.org/10.3390/foods8010037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352122PMC
January 2019
4 Reads

Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.

Diabetes Res Clin Pract 2019 Jan 18;148:200-211. Epub 2019 Jan 18.

Metastasis Research Laboratory, GIGA-Cancer, University of Liège, Belgium. Electronic address:

Diabetes is one of the most frequent diseases throughout the world and its incidence is predicted to exponentially progress in the future. This metabolic disorder is associated with major complications such as neuropathy, retinopathy, atherosclerosis, and diabetic nephropathy, the severity of which correlates with hyperglycemia, suggesting that they are triggered by high glucose condition. Reducing sugars and reactive carbonyl species such as methylglyoxal (MGO) lead to glycation of proteins, lipids and DNA and the gradual accumulation of advanced glycation end products (AGEs) in cells and tissues. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.002DOI Listing
January 2019
9 Reads
2.538 Impact Factor

TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways.

Am J Hum Genet 2019 Feb 17;104(2):348-355. Epub 2019 Jan 17.

Laboratory of Hereditary Kidney Diseases, Imagine Institute, INSERM U1163, Paris Descartes University, 75015 Paris, France; Department of Genetics, Reference center for Hereditary Kidney Diseases (MARHEA), Necker Hospital, APHP,75015 Paris, France. Electronic address:

Steroid-resistant nephrotic syndrome (SRNS) is characterized by high-range proteinuria and most often focal and segmental glomerulosclerosis (FSGS). Identification of mutations in genes causing SRNS has improved our understanding of disease mechanisms and highlighted defects in the podocyte, a highly specialized glomerular epithelial cell, as major factors in disease pathogenesis. By exome sequencing, we identified missense mutations in TBC1D8B in two families with an X-linked early-onset SRNS with FSGS. Read More

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http://dx.doi.org/10.1016/j.ajhg.2018.12.016DOI Listing
February 2019
2 Reads
10.931 Impact Factor

Methylglyoxal evokes acute Ca transients in distinct cell types and increases agonist-evoked Ca entry in endothelial cells via CRAC channels.

Cell Calcium 2019 Mar 9;78:66-75. Epub 2019 Jan 9.

Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. Electronic address:

Methylglyoxal (MG) is a by-product of glucose metabolism and its accumulation has been linked to the development of diabetic complications such as retinopathy and nephropathy by affecting multiple signalling pathways. However, its influence on the intracellular Ca homeostasis and particularly Ca entry, which has been reported to be mediated via TRPA1 channels in DRG neurons, has not been studied in much detail in other cell types. In this study, we report the consequences of acute and long-term MG application on intracellular Ca levels in endothelial cells. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.01.002DOI Listing
March 2019
2 Reads

[Preeclampsia - a disease of pregnant women].

Postepy Biochem 2018 12;64(4):232-229

Pracownia Białek Wiążących Wapń, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.

Preeclampsia, also known as EPH-gestosis, is a pregnancy-specific syndrome. It affects 3-5% of pregnant women and is characterized by edemas, high blood pressure and proteinuria. Moreover, in women with preeclampsia dysfunction of many organs, such as kidney and liver, is diagnosed, while in the case of fetus growth restriction is observed. Read More

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http://dx.doi.org/10.18388/pb.2018_146DOI Listing
December 2018
4 Reads

Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective.

J Intensive Care Med 2019 Jan 17:885066618824531. Epub 2019 Jan 17.

1 Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Acute kidney injury (AKI) is a common and serious medical condition associated with significant increases in morbidity, mortality, and cost of care. Because of the high incidence and poor outcomes associated with AKI, there has been significant interest in the development of new therapies for the prevention and treatment of the disease. A lack of efficacy in drug trials led to the concern that AKI was not being diagnosed early enough for an effective intervention and that a rise in serum creatinine itself is not a sensitive-enough marker. Read More

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http://dx.doi.org/10.1177/0885066618824531DOI Listing
January 2019
1 Read

Autophagy in Chronic Kidney Diseases.

Cells 2019 Jan 16;8(1). Epub 2019 Jan 16.

Department of Cardiology, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan City 333, Taiwan.

Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic nephropathies, and polycystic kidney diseases. Read More

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http://dx.doi.org/10.3390/cells8010061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357204PMC
January 2019
2 Reads

A fully adjusted two-stage procedure for rank-normalization in genetic association studies.

Genet Epidemiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Biostatistics, University of Washington, Seattle, Washington.

When testing genotype-phenotype associations using linear regression, departure of the trait distribution from normality can impact both Type I error rate control and statistical power, with worse consequences for rarer variants. Because genotypes are expected to have small effects (if any) investigators now routinely use a two-stage method, in which they first regress the trait on covariates, obtain residuals, rank-normalize them, and then use the rank-normalized residuals in association analysis with the genotypes. Potential confounding signals are assumed to be removed at the first stage, so in practice, no further adjustment is done in the second stage. Read More

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http://dx.doi.org/10.1002/gepi.22188DOI Listing
January 2019
1 Read

Genetics of polycystic liver diseases.

Curr Opin Gastroenterol 2019 Mar;35(2):65-72

Department of Gastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

Purpose Of Review: This review provides an outline of the most recent insights and significant discoveries regarding the genetic mechanisms involved in polycystic liver disease.

Recent Findings: Polycystic liver disease includes a heterogeneous group of genetic disorders characterized by multiple hepatic cysts. Isolated liver cysts are caused by mutations in Protein Kinase C Substrate 80K-H (PRKCSH), SEC63, and LDL Receptor Related Protein 5 (LRP5), whereas Polycystic Kidney Disease (PKD)1, PKD2, and PKHD1 mutations cause kidney cysts often accompanied by liver cysts. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000514DOI Listing
March 2019
2 Reads

Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model.

PLoS One 2019 10;14(1):e0209351. Epub 2019 Jan 10.

Department of Clinical Medicine, Laboratory of Experimental Therapeutics, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

Background: The imbalance between pro- and anti-inflammatory immune responses plays a pivotal role in chronic obstructive pulmonary disease (COPD) development and progression. To clarify the pathophysiological mechanisms of this disease, we performed a temporal analysis of immune response-mediated inflammatory progression in a cigarette smoke (CS)-induced mouse model with a focus on the balance between Th17 and Treg responses.

Methods: C57BL/6 mice were exposed to CS for 1, 3 or 6 months to induce COPD, and the control groups were maintained under filtered air conditions for the same time intervals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209351PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328193PMC
January 2019
8 Reads

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

Front Immunol 2018 20;9:3035. Epub 2018 Dec 20.

III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Membranous nephropathy (MN) is an autoimmune disease caused by binding of circulating antibodies to podocyte antigens in the kidney. For decades and still today primary MN has been considered to have an unspecified IgG4-driven autoimmune genesis, while secondary MN has been associated with other diseases, most notably cancer, and not linked to IgG4. Immunologic mechanisms of primary and malignancy-associated MN are assumed to be different, however, this has never been systematically evaluated. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03035
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http://dx.doi.org/10.3389/fimmu.2018.03035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306563PMC
December 2018
5 Reads

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications.

Front Pharmacol 2018 19;9:1488. Epub 2018 Dec 19.

UCD Diabetes Complications Research Centre, Conway Institute and UCD School of Medicine, University College Dublin, Dublin, Ireland.

Diabetes and its associated chronic complications present a healthcare challenge on a global scale. Despite improvements in the management of chronic complications of the micro-/macro-vasculature, their growing prevalence and incidence highlights the scale of the problem. It is currently estimated that diabetes affects 425 million people globally and it is anticipated that this figure will rise by 2025 to 700 million people. Read More

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http://dx.doi.org/10.3389/fphar.2018.01488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305798PMC
December 2018
1 Read

Characteristics and associated factors of acute kidney injury among adult dengue patients: A retrospective single-center study.

PLoS One 2019 7;14(1):e0210360. Epub 2019 Jan 7.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Severe dengue cases have been increasingly reported in Thailand, and the under-reporting of acute kidney injury (AKI) in cases of dengue viral infection has become an obstacle in obtaining an accurate description of the true nature and epidemiology of AKI. Because AKI may lead to patient morbidity and mortality, an early diagnosis is important in preventing its onset in dengue patients. This study aimed to determine the prevalence, clinical and laboratory characteristics, and associated factors of AKI among adult dengue patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210360PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322747PMC
January 2019
5 Reads

Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases.

Adv Nutr 2019 Jan;10(1):112-121

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Kidney diseases are common health problems worldwide. Various etiologies (e.g. Read More

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https://academic.oup.com/advances/advance-article/doi/10.109
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http://dx.doi.org/10.1093/advances/nmy077DOI Listing
January 2019
16 Reads

Prevalence of hypertension, diabetes, and associated risk factors among geriatric population living in a high-altitude region of rural Uttarakhand, India.

J Family Med Prim Care 2018 Nov-Dec;7(6):1527-1536

Department of Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Background: Hypertension (HTN) and diabetes mellitus (DM) both are rapidly emerging as public health problems among geriatric population in developing countries. HTN can lead to stroke, myocardial infarction, congestive heart failure, and chronic kidney diseases among geriatric population. DM increases the risk of coronary heart disease, cerebrovascular disease, peripheral vascular disease, retinopathy, nephropathy, and neuropathy among geriatric population. Read More

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http://www.jfmpc.com/text.asp?2018/7/6/1527/246443
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http://dx.doi.org/10.4103/jfmpc.jfmpc_108_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293909PMC
January 2019
5 Reads

Identification of competitive inhibitors of the human taurine transporter TauT in a human kidney cell line.

Pharmacol Rep 2018 Oct 24;71(1):121-127. Epub 2018 Oct 24.

Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.

Background: The osmolyte and antioxidant taurine plays an important role in regulation of cellular volume, oxidative status and Ca-homeostasis. Taurine uptake in human cells is regulated by the Na- and Cl-dependent taurine transporter TauT. In order to gain deeper structural insights about the substrate binding pocket of TauT, a HEK293 cell line producing a GFP-TauT fusion protein was generated. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.005DOI Listing
October 2018
2 Reads

A comprehensive data level analysis for cancer diagnosis on imbalanced data.

J Biomed Inform 2019 Jan 2. Epub 2019 Jan 2.

Department of Quantitative Health Sciences, Cleveland Cancer Foundation, Cleveland, Ohio. Electronic address:

The early diagnosis of cancer, as one of the major causes of death, is vital for cancerous patients. Diagnosing diseases in general and cancer in particular is a considerable application of data analysis for medical science. However, imbalanced data distribution and imbalanced quality of the majority and minority classes, which lead to misclassification, is a great challenge in this field. Read More

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http://dx.doi.org/10.1016/j.jbi.2018.12.003DOI Listing
January 2019
2 Reads

Endothelium structure and function in kidney health and disease.

Nat Rev Nephrol 2019 Feb;15(2):87-108

INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France.

The kidney harbours different types of endothelia, each with specific structural and functional characteristics. The glomerular endothelium, which is highly fenestrated and covered by a rich glycocalyx, participates in the sieving properties of the glomerular filtration barrier and in the maintenance of podocyte structure. The microvascular endothelium in peritubular capillaries, which is also fenestrated, transports reabsorbed components and participates in epithelial cell function. Read More

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http://dx.doi.org/10.1038/s41581-018-0098-zDOI Listing
February 2019
3 Reads

Sustained Klotho delivery reduces serum phosphate in a model of diabetic nephropathy.

J Appl Physiol (1985) 2019 Jan 3. Epub 2019 Jan 3.

Dept. of Medical & Molecular Genetics, Indiana Univ. Sch. of Med., United States.

Diabetic nephropathy (DN) is a primary cause of end-stage renal disease and is becoming more prevalent due to the global rise of type 2 diabetes. A model of DN, the db/db uninephrectomized (db/db-uni) mouse, is characterized by obesity, as well as compromised renal function. This model also manifests defects in mineral metabolism common in DN including hyperphosphatemia, which leads to severe endocrine disease. Read More

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http://dx.doi.org/10.1152/japplphysiol.00838.2018DOI Listing
January 2019
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Loss of estrogen-related receptor alpha facilitates angiogenesis in endothelial cells.

Mol Cell Biol 2019 Jan 2. Epub 2019 Jan 2.

Metabolic and Degenerative Diseases, Institute of Molecular Medicine, The University of Texas McGovern Medical School, Houston, TX, USA.

Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature remains unknown. Here we report the transcriptional program and cellular function of ERRα in endothelial cells (ECs), a cell type with a multi-faceted role in vasculature. Read More

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http://dx.doi.org/10.1128/MCB.00411-18DOI Listing
January 2019
2 Reads

Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

School of Pharmacy, Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, 710069, Shaanxi, China.

Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1756-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317198PMC
January 2019
6 Reads
3.930 Impact Factor

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.

J Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Pharmaron Beijing Co., Ltd. , No. 6 Taihe Road, BDA , Beijing 100176 , P. R. China.

The mechanism-based risk for hyperkalemia has limited the use of mineralocorticoid receptor antagonists (MRAs) like eplerenone in cardio-renal diseases. Here, we describe the structure and property-driven lead generation and optimization, which resulted in identification of MR modulators ( S)-1 and ( S)-33. Both compounds were partial MRAs but still demonstrated equally efficacious organ protection as eplerenone after 4 weeks of treatment in uni-nephrectomized rats on high-salt diet and aldosterone infusion. Read More

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01523
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http://dx.doi.org/10.1021/acs.jmedchem.8b01523DOI Listing
January 2019
3 Reads

Position of cytoreductive nephrectomy in the setting of metastatic renal cell carcinoma patients: does the CARMENA trial lead to a paradigm shift?

Bull Cancer 2018 Dec;105 Suppl 3:S229-S234

Department of Urology, hôpital européen Georges-Pompidou, Paris-Descartes University, 20, rue Leblanc, 75015 Paris, France.

Introduction > The role of cytoreductive nephrectomy (CN) in combination with targeted therapy has been debated after the results of the CARMENA trial. We decided to reassess the available evidence on the setting of CN in metastatic renal cell carcinoma (mRCC) patients. Methods > Critical review of the literature focusing on CN in mRCC patients. Read More

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http://dx.doi.org/10.1016/S0007-4551(18)30377-1DOI Listing
December 2018
1 Read

Multiple myeloma with crystal-storing histiocytosis, crystalline podocytopathy, and light chain proximal tubulopathy, revealed by retinal abnormalities: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13638

Department of Internal Medicine, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Rationale: Crystal sorting histiocytosis (CSH) is a rare disorder that is morphologically characterized by the accumulation of monoclonal immunoglobulin crystals, predominantly of a kappa light chain type, within lysosomes of macrophages. CSH may result in a variety of clinical manifestations depending on the involved organs. In this case report, we aim to describe a patient with ophthalmic manifestations which lead to the diagnosis of multiple myeloma with crystal-storing histiocytosis, crystalline podocytopathy, and light chain proximal tubulopathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314660PMC
December 2018
1 Read

Diagnostic Utility of Exome Sequencing for Kidney Disease.

N Engl J Med 2019 01 26;380(2):142-151. Epub 2018 Dec 26.

From the Departments of Medicine (E.E.G., M.M., H.M.-R., Y.L., J.Z., J.N., P.K., W.Y.L., A.M., S. Piva, B.H.K., D.C., R.R., D.B., M.D., H.S., X.M., K.M., O.B., J.R., P.C., G.B.A., A.S.B., W.A., D.J.C., R.J.C., G.K.D., M.K.R., S.M., S.S.-C., K.K., A.G.G.) and Pediatrics (N.S.U.), Division of Nephrology, the Departments of Pathology (V.S.A.), Biomedical Informatics (D.A.F., C.W.), and Urology (S.A.), the Institute for Genomic Medicine (S.K., B.C., Z.R., J.B., C.D.M., C.M.M., N.D., D.B.G., A.G.G.) and the Department of Genetics and Development (D.B.G.), Hammer Health Sciences, and the Department of Epidemiology, Mailman School of Public Health (S.M.), Columbia University, New York; AstraZeneca Centre for Genomics Research, Precision Medicine and Genomics, Innovative Medicines and Early Development (IMED) Biotech Unit, Cambridge, United Kingdom (S.C.-C., S. Petrovski, C.H., J.F., R.M., A.P.); and the Department of Medical Science, Renal Unit, Uppsala University Hospital, Uppsala, Sweden (B.C.F.).

Background: Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders in adults, including chronic kidney disease, which affects more than 1 in 10 persons globally.

Methods: We conducted exome sequencing and diagnostic analysis in two cohorts totaling 3315 patients with chronic kidney disease. We assessed the diagnostic yield and, among the patients for whom detailed clinical data were available, the clinical implications of diagnostic and other medically relevant findings. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1806891
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http://dx.doi.org/10.1056/NEJMoa1806891DOI Listing
January 2019
13 Reads
55.873 Impact Factor

The impact of using a closed-loop system on food choices and eating practices among people with Type 1 diabetes: a qualitative study involving adults, teenagers and parents.

Diabet Med 2018 Dec 21. Epub 2018 Dec 21.

Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Aims: We explored whether, how and why moving onto and using a hybrid day-and-night closed-loop system affected people's food choices and dietary practices to better understand the impact of this technology on everyday life and inform recommendations for training and support given to future users.

Methods: Twenty-four adults, adolescents and parents were interviewed before commencing use of the closed-loop system and following its 3-month use. Data were analysed thematically and longitudinally. Read More

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http://dx.doi.org/10.1111/dme.13887DOI Listing
December 2018

Creatinine Rise During Blood Pressure Therapy and the Risk of Adverse Clinical Outcomes in Patients With Type 2 Diabetes Mellitus.

Hypertension 2018 Dec;72(6):1337-1344

From the Department of Vascular Medicine (D.C., B.-J.H.v.d.B.), Academic Medical Center, University of Amsterdam, The Netherlands.

Lowering blood pressure may affect renal function. Current guidelines state that reducing antihypertensive therapy should be considered in patients with a >30% serum creatinine increase after initiation of antihypertensive therapy. We examined the association between a serum creatinine increase and adverse clinical outcomes in the ACCORD-BP trial (Action to Control Cardiovascular Risk in Diabetes Blood Pressure), were patients with type 2 diabetes mellitus were randomized to intensive (target systolic blood pressure <120 mm Hg) and standard antihypertensive (<140 mm Hg) treatment. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11944DOI Listing
December 2018
1 Read